70 results on '"Díte P"'
Search Results
2. Continued fractions and parametric geometry of numbers
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Keita, Aminata Dite Tanti
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Mathematics - Number Theory ,11J04, 11J82 - Abstract
Recently, W. M. Schmidt and L. Summerer developed a new theory called Parametric Geometry of Numbers which approximates the behaviour of the successive minima of a family of convex bodies in $\mathbb{R}^{n}$ related to the problem of simultaneous rational approximation to given real numbers. In the case of one number, we show that the qualitative behaviour of the minima reflects the continued fraction expansion of the smallest distance from this number to an integer., Comment: 6 pages, 2 figures
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- 2015
3. Seroepidemiology of whooping cough in the Czech Republic: estimates of incidence of infection in adults
- Author
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Chlibek, R., Smetana, J., Sosovickova, R., Fabianova, K., Zavadilova, J., Dite, P., Gal, P., Naplava, P., and Lzicarova, D.
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- 2017
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4. Value and price in museum theory and practice (Hodnota a cena v múzejnej teórii a praxi)
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Tibor Díte
- Subjects
acquisitions ,axiology ,price ,pricing ,value ,museality ,museum ,valuation ,objects of cultural value ,Museums. Collectors and collecting ,AM1-501 - Abstract
This paper analyzes the development and the current state of axiology in Slovak museums in its historical and legislative context. Additionally, we attempt to define the values that are – or should be – applied to the valuation of objects in museum collections, as well as said valuation’s philosophical, economic and museological underpinnings. The final section of the paper then proposes a pricing tool specifically designed for the evaluation of pricing offers and purchase prices of museum objects during the creation of museum collections.
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- 2016
5. Occurrence of Metabolic Osteopathy in Patients with Chronic Pancreatitis
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Dujsikova, H., Dite, P., Tomandl, J., Sevcikova, A., and Precechtelova, M.
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- 2008
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6. Pancreatic solid focal lesions: autoimmune pancreatitis or pancreatic cancer?
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Kunovsky, L., Dite, P., Dolina, J., Kala, Z., Blaho, M., Dvorackova, J., Uvirova, M., Jabandziev, P., Janecek, P., Eid, M., Rohan, T., Maskova, H., Poredska, K., Vaculova, J., and Trna, J.
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- 2020
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7. Corrigendum to “Recommendations from the United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis” [Pancreatology 18(8) (2018) 847–854]
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Löhr, M., Dominguez-Munoz, J.E., Besselink, M., Mayerle, J., Rosendahl, J., Lerch, M.M., Akisik, F., Kartalis, N., Manfredi, R., Iglesias-Garcia, J., Haas, S.L., Keller, J., Boermeester, M.A., Werner, J., Dumonceau, J.M., Fockens, P., Drewes, A., Cheyan, G.O., Lindkvist, B., Drenth, J.P., Ewald, N., Hardt, P., de Madaria, E., Gheorghe, C., Lindgren, F., Schneider, A., Witt, H., Bollen, T., Boraschi, P., Frøkjær, J.B., Rudolf, S., Bruno, M., Dimcevski, G., Giovannini, M., Pukitis, A., Petrone, M., Oppong, K., Ammori, B., Friess, H., Izbiki, J.R., Ganeh, P., Salvia, R., Sauvanet, A., Barbu, S., Lyadov, V., Deprez, P., Gubergrits, N., Okhlobystiy, A.V., Arvanitakis, M., Costamagna, G., Pap, A., Andersson, R., Hauge, T., McKay, C., Regnér, S., Dite, P., Olesen, S.S., Duggan, S., Hopper, A., Phillips, M., Shvets, O., Vujasinovic, M., Czako, L., Piemonti, L., Kocher, H., Rebours, V., Stimac, D., Hegyi, P., Drewes, A.M., Czakó, L., and Löhr, J.M.
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- 2020
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8. Vegetation classification and ecology of Pannonian salt lake beds
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Díte, Daniel, Eliáš Jr., Pavol, Díte, Zuzana, Píš, Vladimír, and Šuvada, Róbert
- Abstract
Abstract Questions: How do published syntaxonomical data of exposed salt lake plant communities from particular countries correspond with our field data sampled throughout the Pannonian Basin? How do the soils and the duration of flooding affect the pattern of individual vegetation types? Is there geographical variation in the vegetation of soda pans within the studied area? Location: Pannonian Basin (lowland parts of Austria, Hungary, Serbia, Slovakia). Methods: We sampled the vegetation on exposed shores and the bottom of 24 soda pans using the nine-grade Braun-Blanquet scale. Three hundred and four phytosociological relevés were classified into clusters representing different associations using TWINSPAN. The relations between the vegetation types were displayed as spiderplots with Detrended Correspondence Analysis (DCA). Chemical soil properties of 64 samples taken from various vegetation types were analysed. DCA with data attribute plots and the LOESS visualisation method were used to display quantitative data. Results: We identified eight clusters representing different associations occurring on the dried bottoms of soda pans: five associations in the class Crypsietea aculeatae, two associations in the class Thero-Salicornietea strictae and a single association in the class Festuco-Puccinellietea. The latter was found only in the littoral zone. Classes were distinct in measured soil properties. Thero-Salicornietea strictae occupied soils with higher values of EC, SAR and ESP. Communities of the class Crypsietea aculeatae occupied soils with higher amounts of Ca, Mg and TOC. Conclusions: We have not confirmed the associations Cyperetum pannonici, Atriplicetum prostratae, Heleochloëtum alopecuroidis and Chenopodietum urbici although all of these syntaxa belonging to the class Crypsietea aculeatae have been traditionally reported from exposed soda pans. The associations Camphorosmetum annuae, Lepidio crassifolii-Camphorosmetum annuae, Lepidietum crassifolii and Spergulario marginatae-Suaedetum prostratae, reported in several literature sources of the class Thero-Salicornietea strictae, were not confirmed in the examined area. They develop in other saline habitats, outside the soda pan bottoms, in the vegetation of the class Festuco-Puccinellietea. ? Nomenclature: Euro+Med (2015).? Abbreviations: Ca = calcium; Mg = magnesium; Na = sodium; ESP = exchangeable sodium percentage; DCA = Detrended correspondence analysis; LOESS = locally weighted scatterplot smoothing; SAR = sodium adsorption ratio; TOC = total organic carbon.? Submitted: 12 May 2016; first decision: 19 July 2016; accepted: 2 October 2017
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- 2017
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9. Relationship between K-ras mutation and the expression of p21WAF1/CIP1 and p53 in chronic pancreatitis and pancreatic adenocarcinoma
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Hermanová M, Lukás Z, Kroupová I, Kleibl Z, Novotný J, Rudolf Nenutil, Pazourková M, Brázdil J, Kren L, and Díte P
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Cyclin-Dependent Kinase Inhibitor p21 ,Pancreatic Ducts ,Adenocarcinoma ,Genes, p53 ,Gene Expression Regulation, Neoplastic ,Pancreatic Neoplasms ,Genes, ras ,Pancreatitis ,Reference Values ,Cyclins ,Chronic Disease ,Mutation ,Humans ,Neoplasm Invasiveness - Abstract
Overexpression of p21WAF1/CIP1 was recently described as an early event in the development of pancreatic intraepithelial neoplasia. Since activating K-ras mutations are described in more than 80% of pancreatic cancers and are known to increase intracellular levels of p21WAF1/CIP1 in experimental models, the possible role of activating K-ras mutations in an induction of the p21WAF1/CIP1 expression was investigated in our study. We examined 71 surgical specimens, 29 of chronic pancreatitis and 42 of invasive ductal adenocarcinoma both having a large spectrum of PanIN (pancreatic intraepithelial neoplasia) lesions. Expression of p53 and p21WAF1/CIP1 was examined immunohistochemically and codon 12 K-ras mutational analysis was performed using the very sensitive mutant-enriched PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) analysis. Our study demonstrated the overexpression of p21WAF1/CIP1 as an early event in the development of pancreatic intraepithelial neoplasia in the group of chronic pancreatitis and invasive adenocarcinoma as well. Overexpression of p21WAF1/CIP1 increased progressively from normal ducts through the spectrum of PanIN lesions to invasive carcinomas. The p53 overexpression increased again progressively according to the severity of the lesion and seems to be a later event in the development of pancreatic intraepithelial neoplasia if compared to p21WAF1/CIP1 expression. Our results confirmed also the possible p53 independent p21WAF1/CIP1 expression in some PanIN2, PanIN3 lesions and invasive carcinomas. K-ras mutations were not revealed in samples with only low grade PanIN lesions (PanIN1a and PanIN1b). K-ras mutations were detected in 69,4% adenocarcinomas and in only one case of chronic pancreatitis. Two codon 12 K-ras positive pancreatic carcinomas showed K-ras mutations in the surrounding normal pancreatic tissue. In adenocarcinomas, no statistically significant correlation was found between K-ras mutational status and p21WAF1/CIP1 and p53 expression, respectively. The possible role of activating K-ras mutations in an induction of p21WAF1/CIP1 expression was not confirmed in this study.
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- 2003
10. Use of sedation for routine diagnostic upper gastrointestinal endoscopy: a European Society of Gastrointestinal Endoscopy Survey of National Endoscopy Society Members.
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UCL - (SLuc) Service de gastro-entérologie, UCL - MD/MINT - Département de médecine interne, Ladas, S D, Aabakken, L, Rey, J-F, Nowak, A, Zakaria, S, Adamonis, K, Amrani, N, Bergman, J J G H M, Boix Valverde, J, Boyacioglu, S, Cremers, I, Crowe, J, Deprez, Pierre Henri, Díte, P, Eisen, M, Eliakim, R, Fedorov, E D, Galkova, Z, Gyokeres, T, Heuss, L T, Husic-Selimovic, A, Khediri, F, Kuznetsov, K, Marek, T, Munoz-Navas, M, Napoleon, B, Niemela, S, Pascu, O, Perisic, N, Pulanic, R, Ricci, E, Schreiber, F, Svendsen, L B, Sweidan, W, Sylvan, A, Teague, R, Tryfonos, M, Urbain, D, Weber, J, Zavoral, M, European Society of Gastrointestinal Endoscopy Survey of National Endoscopy Society Members, UCL - (SLuc) Service de gastro-entérologie, UCL - MD/MINT - Département de médecine interne, Ladas, S D, Aabakken, L, Rey, J-F, Nowak, A, Zakaria, S, Adamonis, K, Amrani, N, Bergman, J J G H M, Boix Valverde, J, Boyacioglu, S, Cremers, I, Crowe, J, Deprez, Pierre Henri, Díte, P, Eisen, M, Eliakim, R, Fedorov, E D, Galkova, Z, Gyokeres, T, Heuss, L T, Husic-Selimovic, A, Khediri, F, Kuznetsov, K, Marek, T, Munoz-Navas, M, Napoleon, B, Niemela, S, Pascu, O, Perisic, N, Pulanic, R, Ricci, E, Schreiber, F, Svendsen, L B, Sweidan, W, Sylvan, A, Teague, R, Tryfonos, M, Urbain, D, Weber, J, Zavoral, M, and European Society of Gastrointestinal Endoscopy Survey of National Endoscopy Society Members
- Abstract
Sedation rates may vary among countries, depending on patients' and endoscopists' preferences. The aim of this survey was to investigate the rate of using premedication for routine diagnostic upper gastrointestinal (UGI) endoscopy in endoscopy societies, members of the European Society of Gastrointestinal Endoscopy (ESGE). We evaluated a multiple-choice questionnaire which was e-mailed to representatives of national endoscopy societies, which are members of the ESGE. The questionnaire had 14 items referring to endoscopy practices in each country and the representatives' endoscopy units. The response rate was 76% (34/45). In 47% of the countries, less than 25% of patients undergo routine diagnostic UGI endoscopy with conscious sedation. In 62% of the responders' endoscopy units, patients are not asked their preference for sedation and do not sign a consent form (59%). Common sedatives in use are midazolam (82%), diazepam (38%) or propofol (47%). Monitoring equipment is not available 'in most of the endoscopy units' in 46% (13/28) of the countries. Though they were available in 91% of the national representatives' endoscopy units, they are rarely (21%) used to monitor unsedated routine diagnostic UGI endoscopy. In about 50% of ESGE-related countries, less than 25% of patients are sedated for routine diagnostic UGI endoscopy. Major issues to improve include availability of monitoring equipment and the use of a consent form.
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- 2006
11. Serum IgG4 positivity in patients with pancreatic cancer
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Dite, P., Trna, J., Novotny, I., Kala, Z., Martinek, A., and Hermanova, M.
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- 2012
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12. Prevalence of pancreatic cancer among patients with newly diagnosed diabetes mellitus
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Trna, J., Dite, P., Novotny, I., Belobradkova, J., and Hermanova, M.
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- 2012
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13. Emergencies and Complications in Gastroenterology : Special Topic Issue: Digestive Diseases 2003, Vol. 21, No. 1
- Author
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Dítě, P. and Dítě, P.
- Subjects
- Gastroenterology
- Abstract
Acute conditions in gastroenterology are typically connected with high morbidity and mortality; an optimal therapy of these conditions demands a close cooperation between several disciplines, particularly gastroenterology and surgery. However, systematic data for a generalized approach to determine the optimal diagnostic procedures and therapy have so far not been available. The publication on hand tries to fill this gap by providing gastroenterologists and surgeons with recommendations for a rational multidisciplinary approach. Acute states are characterized by multifactorial etiological changes as well as polymorbidity, which have an adverse influence on diagnostic accuracy and effect of therapy. In this situation, endoscopic examination which enables a simultaneous therapeutical solution is of fundamental importance. However, endoscopy is an invasive method, and due to patients'polymorbidity, endoscopic approaches are limited by their general clinical condition, particularly by cardiopulmonary compensation. In these cases, non-invasive diagnostic methods are called for, such as ultrasound, computer tomography (CT) or nuclear magnetic resonance imaging. Moreover, modifications of these methods, e.g. CT-enteroclysis or CT-colonography, provide very precise and immediate results that allow to adopt the optimal strategic method. These methods may in the future substitute endoscopic examinations. This publication has been especially compiled for gastroenterologists, endoscopists, surgeons, intensivists and physicians involved in the management of acute cases to help them determine the optimal therapy for their patients.
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- 2003
14. Use of Sedation for Routine Diagnostic Upper Gastrointestinal Endoscopy: A European Society of Gastrointestinal Endoscopy Survey of National Endoscopy Society Members.
- Author
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Ladas, S. D., Aabakken, L., Rey, J.-F., Nowak, A., Zakaria, S., Adamonis, K., Amrani, N., Bergman, J. J. G. H. M., Valverde, J. Boix, Boyacioglu, S., Cremers, I., Crowe, J., Deprez, P., Díte, P., Eisen, M., Eliakim, R., Fedorov, E. D., Galkova, Z., Gyokeres, T., and Heuss, L. T.
- Subjects
ANESTHESIA ,ENDOSCOPY ,GASTROINTESTINAL system ,MIDAZOLAM ,DIAZEPAM - Abstract
Background/Aims: Sedation rates may vary among countries, depending on patients’ and endoscopists’ preferences. The aim of this survey was to investigate the rate of using premedication for routine diagnostic upper gastrointestinal (UGI) endoscopy in endoscopy societies, members of the European Society of Gastrointestinal Endoscopy (ESGE). Methods: We evaluated a multiple-choice questionnaire which was e-mailed to representatives of national endoscopy societies, which are members of the ESGE. The questionnaire had 14 items referring to endoscopy practices in each country and the representatives’ endoscopy units. Results: The response rate was 76% (34/45). In 47% of the countries, less than 25% of patients undergo routine diagnostic UGI endoscopy with conscious sedation. In 62% of the responders’ endoscopy units, patients are not asked their preference for sedation and do not sign a consent form (59%). Common sedatives in use are midazolam (82%), diazepam (38%) or propofol (47%). Monitoring equipment is not available ‘in most of the endoscopy units’ in 46% (13/28) of the countries. Though they were available in 91% of the national representatives’ endoscopy units, they are rarely (21%) used to monitor unsedated routine diagnostic UGI endoscopy. Conclusions: In about 50% of ESGE-related countries, less than 25% of patients are sedated for routine diagnostic UGI endoscopy. Major issues to improve include availability of monitoring equipment and the use of a consent form. Copyright © 2006 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
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- 2006
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15. A prospective, randomized trial comparing endoscopic and surgical therapy for chronic pancreatitis.
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Díte, P, Ruzicka, M, Zboril, V, and Novotný, I
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- 2003
16. PP072-SUN DIETARY INTERVENTION SHOULD BE A PART OF A SURVEILLANCE PROGRAMME FOR THE FIRST-DEGREE RELATIVES OF PATIENTS WITH COLORECTAL NEOPLASIAS
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Kaizrlikova, I., Vitek, P., Dite, P., Chalupa, J., Kuchar, J., Platos, J., and Reha, P.
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- 2011
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17. Remote locality of the littoral Carex extensa(Cyperaceae) in Hungary — long distance dispersal from coastal to inland salt marshes
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Király, Gergely, Bidló, András, Takács, Gábor, Eliáš, Pavol, Melecková, Zuzana, and Díte, Daniel
- Abstract
A remarkable population of Carex extensa(Cyperaceae) was found south of Lake Ferto (Neusiedler See) in Hungary in 2012. This species typically occurs in coastal salt marshes in Europe and was hitherto unknown from the Pannonian Basin. The locality is situated in a territory which has been embanked in 1911. Keeping also in mind that the vegetation developed here from reed beds to saline habitats, we conclude that C. extensareached the salt marshes of the area through long distance dispersal by water birds from the European coast in the last century. Nevertheless, several other maritime littoral species grow in the region, and the possibility that there is a hidden population of C. extensaat another site(s) nearby cannot be excluded. Lake Ferto is often described as the “westernmost steppe lake” and supports one of the richest European inland littoral floras. Although it appears likely that C. extensahas only recently colonised the site, we consider this discovery to be of significant biogeographical importance.
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- 2013
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18. Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study
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Johnson, Nichola, Dudbridge, Frank, Orr, Nick, Gibson, Lorna, Jones, Michael E, Schoemaker, Minouk J, Folkerd, Elizabeth J, Haynes, Ben P, Hopper, John L, Southey, Melissa C, Dite, Gillian S, Apicella, Carmel, Schmidt, Marjanka K, Broeks, Annegien, Van’t Veer, Laura J, Atsma, Femke, Muir, Kenneth, Lophatananon, Artitaya, Fasching, Peter A, Beckmann, Matthias W, Ekici, Arif B, Renner, Stefan P, Sawyer, Elinor, Tomlinson, Ian, Kerin, Michael, Miller, Nicola, Burwinkel, Barbara, Marme, Frederik, Schneeweiss, Andreas, Sohn, Christof, Guénel, Pascal, Truong, Therese, Cordina, Emilie, Menegaux, Florence, Bojesen, Stig E, Nordestgaard, Børge G, Flyger, Henrik, Milne, Roger, Zamora, M Pilar, Arias Perez, Jose Ignacio, Benitez, Javier, Bernstein, Leslie, Anton-Culver, Hoda, Ziogas, Argyrios, Clarke Dur, Christina, Brenner, Hermann, Müller, Heiko, Arndt, Volker, Dieffenbach, Aida Karina, Meindl, Alfons, Heil, Joerg, Bartram, Claus R, Schmutzler, Rita K, Brauch, Hiltrud, Justenhoven, Christina, Ko, Yon-Dschun, Nevanlinna, Heli, Muranen, Taru A, Aittomäki, Kristiina, Blomqvist, Carl, Matsuo, Keitaro, Dörk, Thilo, Bogdanova, Natalia V, Antonenkova, Natalia N, Lindblom, Annika, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M, Chenevix-Trench, Georgia, Beesley, Jonathan, Wu, Anna H, Van den Berg, David, Tseng, Chiu-Chen, Lambrechts, Diether, Smeets, Dominiek, Neven, Patrick, Wildiers, Hans, Chang-Claude, Jenny, Rudolph, Anja, Nickels, Stefan, Flesch-Janys, Dieter, Radice, Paolo, Peterlongo, Paolo, Bonanni, Bernardo, Pensotti, Valeria, Couch, Fergus J, Olson, Janet E, Wang, Xianshu, Fredericksen, Zachary, Pankratz, Vernon S, Giles, Graham G, Severi, Gianluca, Baglietto, Laura, Haiman, Chris, Simard, Jacques, Goldberg, Mark S, Labrèche, France, Dumont, Martine, Soucy, Penny, Teo, Soo, Yip, Cheng Har, Phuah, Sze Yee, Cornes, Belinda K, Kristensen, Vessela N, Grenaker Alnæs, Grethe, Børresen-Dale, Anne-Lise, Zheng, Wei, Winqvist, Robert, Pylkäs, Katri, Jukkola-Vuorinen, Arja, Grip, Mervi, Andrulis, Irene L, Knight, Julia A, Glendon, Gord, Mulligan, Anna Marie, Devillee, Peter, Figueroa, Jonine, Chanock, Stephen J, Lissowska, Jolanta, Sherman, Mark E, Hall, Per, Schoof, Nils, Hooning, Maartje, Hollestelle, Antoinette, Oldenburg, Rogier A, Tilanus-Linthorst, Madeleine, Liu, Jianjun, Cox, Angie, Brock, Ian W, Reed, Malcolm WR, Cross, Simon S, Blot, William, Signorello, Lisa B, Pharoah, Paul DP, Dunning, Alison M, Shah, Mitul, Kang, Daehee, Noh, Dong-Young, Park, Sue K, Choi, Ji-Yeob, Hartman, Mikael, Miao, Hui, Lim, Wei Yen, Tang, Anthony, Hamann, Ute, Försti, Asta, Rüdiger, Thomas, Ulmer, Hans Ulrich, Jakubowska, Anna, Lubinski, Jan, Jaworska-Bieniek, Katarzyna, Durda, Katarzyna, Sangrajrang, Suleeporn, Gaborieau, Valerie, Brennan, Paul, McKay, James, Slager, Susan, Toland, Amanda E, Vachon, Celine, Yannoukakos, Drakoulis, Shen, Chen-Yang, Yu, Jyh-Cherng, Huang, Chiun-Sheng, Hou, Ming-Feng, González-Neira, Anna, Tessier, Daniel C, Vincent, Daniel, Bacot, Francois, Luccarini, Craig, Dennis, Joe, Michailidou, Kyriaki, Bolla, Manjeet K, Wang, Jean, Easton, Douglas F, García-Closas, Montserrat, Dowsett, Mitch, Ashworth, Alan, Swerdlow, Anthony J, Peto, Julian, dos Santos Silva, Isabel, and Fletcher, Olivia
- Abstract
Introduction: We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years. Methods: We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Genotyping of rs10235235 was conducted using a custom Illumina Infinium array. Stratified analyses were conducted to determine whether this association was modified by age at diagnosis, ethnicity, age at menarche or tumor characteristics. Results: We confirmed the association of rs10235235 with breast cancer risk for women of European ancestry but found no evidence that this association differed with age at diagnosis. Heterozygote and homozygote odds ratios (ORs) were OR = 0.98 (95% CI 0.94, 1.01; P = 0.2) and OR = 0.80 (95% CI 0.69, 0.93; P = 0.004), respectively (Ptrend = 0.02). There was no evidence of effect modification by tumor characteristics. rs10235235 was, however, associated with age at menarche in controls (Ptrend = 0.005) but not cases (Ptrend = 0.97). Consequently the association between rs10235235 and breast cancer risk differed according to age at menarche (Phet = 0.02); the rare allele of rs10235235 was associated with a reduction in breast cancer risk for women who had their menarche age ≥15 years (ORhet = 0.84, 95% CI 0.75, 0.94; ORhom = 0.81, 95% CI 0.51, 1.30; Ptrend = 0.002) but not for those who had their menarche age ≤11 years (ORhet = 1.06, 95% CI 0.95, 1.19, ORhom = 1.07, 95% CI 0.67, 1.72; Ptrend = 0.29). Conclusions: To our knowledge rs10235235 is the first single nucleotide polymorphism to be associated with both breast cancer risk and age at menarche consistent with the well-documented association between later age at menarche and a reduction in breast cancer risk. These associations are likely mediated via an effect on circulating hormone levels.
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- 2014
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19. Plant communities dominated by Pinus mugo agg. in Central Europe – comparison of the oligotrophic communities rich in Sphagnum
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Šibík, Jozef, Díte, Daniel, Šibíková, Ivana, and Pukajová, Drahoslava
- Abstract
This paper deals with ecology, syntaxonomy and nomenclature of species poor Pinus mugo agg. communities in Central Europe. Cluster analyses have generally confirmed the geographical and altitudinal differentiation of Pinus mugo scrubs on peaty soils, and refer to important differentiation between zonal dwarf pine stands and stands on raised bogs and their margins, or in inversion sites. Individual clusters markedly differ in their affinity to major ecological factors. They are associated with light availability and moisture, and correlated with low nutrient availability and acid soil reaction. Three main types are distinguished: subalpine communities of the Western Carpathians and Sudetes belonging to the Pinion mugo Pawlowski in Pawlowski et al. 1928 (the Roso pendulinae-Pinetea mugo Theurillat in Theurillat et al. 1995); slightly wooded raised bogs and their margins dominated by Pinus mugo s. str. in (montane) subalpine areas of European mountains (the Sphagno magellanici-Pinetum mugo Hadac, Ježek et Brezina 1969 nom. cons. propos.); and slightly wooded sub-continental Pinus rotundata stands of raised bogs and their margins (laggs) in montane areas of Hercynian-Sudetic region (the Pinetum rotundatae Kästner et Flößner 1933 corr. Mucina in Steiner 1993). Different physiognomy of raised bogs and bog margins plant communities, dominated by shrubs and trees, reflects the different ecological characteristics of their stands. Sphagno magellanici-Pinetum mugo and the Pinetum rotundatae were previously evaluated within the raised bog communities (the Oxycocco-Sphagnetea Br.-Bl. et R. Tx. ex Westhoff et al. 1946) and the montane spruce woodlands (the Vaccinio-Piceetea Br.-Bl. in Br.-Bl. et al. 1939), however we propose to include them within the Vaccinio uliginosi-Pinetea sylvestris Passarge 1968 class, which includes more or less peaty, azonal, oligotrophic coniferous tree- and shrub-communities in the boreal and mountain regions.
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- 2008
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20. Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk
- Author
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Stevens, K N, Garcia-Closas, M, Fredericksen, Z, Kosel, M, Pankratz, V S, Hopper, J L, Dite, G S, Apicella, C, Southey, M C, Schmidt, M K, Broeks, A, Van ‘t Veer, L J, Tollenaar, R A E M, Fasching, P A, Beckmann, M W, Hein, A, Ekici, A B, Johnson, N, Peto, J, dos Santos Silva, I, Gibson, L, Sawyer, E, Tomlinson, I, Kerin, M J, Chanock, S, Lissowska, J, Hunter, David J., Hoover, R N, Thomas, G D, Milne, R L, Pérez, JI Arias, González-Neira, A, Benítez, J, Burwinkel, B, Meindl, A, Schmutzler, R K, Bartrar, C R, Hamann, U, Ko, Y D, Brüning, T, Chang-Claude, J, Hein, R, Wang-Gohrke, S, Dörk, T, Schürmann, P, Bremer, M, Hillemanns, P, Bogdanova, N, Zalutsky, J V, Rogov, Y I, Antonenkova, N, Lindblom, A, Margolin, S, Mannermaa, A, Kataja, V, Kosma, V-M, Hartikainen, J, Chenevix-Trench, G, Chen, X, Peterlongo, P, Bonanni, B, Bernard, L, Manoukian, S, Wang, X, Cerhan, J, Vachon, C M, Olson, J, Giles, G G, Baglietto, L, McLean, C A, Severi, G, John, E M, Miron, Alexander, Winqvist, R, Pylkäs, K, Jukkola-Vuorinen, A, Grip, M, Andrulis, I, Knight, J A, Glendon, G, Mulligan, A M, Cox, A, Brock, I W, Elliott, G, Cross, S S, Pharoah, P P, Dunning, A M, Pooley, K A, Humphreys, M K, Wang, J, Kang, D, Yoo, K-Y, Noh, D-Y, Sangrajrang, S, Gabrieau, V, Brennan, P, McKay, J, Anton-Culver, H, Ziogas, A, Couch, F J, and Easton, D F
- Subjects
genetic susceptibility ,neoplasms ,association study - Abstract
Background: Somatic mutations in phosphoinositide-3-kinase catalytic subunit alpha (PIK3CA) are frequent in breast tumours and have been associated with oestrogen receptor (ER) expression, human epidermal growth factor receptor-2 overexpression, lymph node metastasis and poor survival. The goal of this study was to evaluate the association between inherited variation in this oncogene and risk of breast cancer. Methods: A single-nucleotide polymorphism from the PIK3CA locus that was associated with breast cancer in a study of Caucasian breast cancer cases and controls from the Mayo Clinic (MCBCS) was genotyped in 5436 cases and 5280 controls from the Cancer Genetic Markers of Susceptibility (CGEMS) study and in 30 949 cases and 29 788 controls from the Breast Cancer Association Consortium (BCAC). Results: Rs1607237 was significantly associated with a decreased risk of breast cancer in MCBCS, CGEMS and all studies of white Europeans combined (odds ratio (OR)=0.97, 95% confidence interval (CI) 0.95–0.99, P=4.6 × \(10^{−3}\)), but did not reach significance in the BCAC replication study alone (OR=0.98, 95% CI 0.96–1.01, P=0.139). Conclusion: Common germline variation in PIK3CA does not have a strong influence on the risk of breast cancer.
- Published
- 2011
- Full Text
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21. Amplification and overexpression of HER-2/neu in invasive ductal carcinomas of the pancreas and pancreatic intraepithelial neoplasms and the relationship to the expression of p21(WAF1/CIP1)
- Author
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Hermanová M, Lukás Z, Rudolf Nenutil, Brázdil J, Kroupová I, Kren L, Pazourková M, Růzicka M, and Díte P
- Subjects
Cyclin-Dependent Kinase Inhibitor p21 ,Transcription, Genetic ,Receptor, ErbB-2 ,Cell Cycle ,G1 Phase ,Cell Differentiation ,Adenocarcinoma ,Immunohistochemistry ,Pancreatic Neoplasms ,Cyclins ,Humans ,Pancreas ,Carcinoma in Situ ,In Situ Hybridization, Fluorescence ,Carcinoma, Pancreatic Ductal - Abstract
Overexpression of HER-2/neu was described in pancreatic intraepithelial neoplasia (PanIN) and in invasive ductal adenocarcinoma of pancreas in a variable proportion of cases. The effects of HER-2/neu overexpression on mitogenic signalling and cell cycle progression were studied in breast luminal epithelial cells and mitogen activated protein kinase-dependent induction of p21(WAF1/CIP1) was found to be necessary for G1 phase progression. Overexpression of p21(WAF1/CIP1) was described as an early event in the development of PanIN by Biankin et al. (2001) and this finding was supported by our previous study that, moreover, did not confirm the possible role of activating K-ras mutations in the induction of p21(WAF1/CIP1) overexpression. Relationship between p21(WAF1/CIP1) expression and HER-2/neu status in PanIN lesions and ductal adenocarcinoma of the pancreas was investigated in our study. Expression levels of p21(WAF1/CIP1) and HER-2/neu were examined imunohistochemically and the amplification of HER-2/neu gene was evaluated by fluorescence in situ hybridisation in HER-2/neu overexpressing adenocarcinomas. Fourty nine pancreatic resection specimens from patients with invasive adenocarcinoma were included into the study. A large spectrum of PanIN lesions adjacent to the structures of infiltrating adenocarcinoma was also examined. The possible role of HER-2/neu in an induction of p21(WAF1/CIP1) overexpression was not confirmed and p21(WAF1/CIP1) overexpression seems to be HER-2/neu independent in pancreatic ductal adenocarcinoma according to our results. Increasing levels of HER-2/neu expression were demonstrated in pancreatic intraepithelial neoplasia and in 18.75% of pancreatic adenocarcinoma. The only 2 from 9 HER-2/neu overexpressing adenocarcinomas showed the amplification of HER-2/neu gene. Based on these results, the overexpression of HER-2/neu in pancreatic adenocarcinoma seems to be a result of increased transcription rather than gene amplification. Therefore HER-2/neu represents a good target for therapy of pancreatic adenocarcinoma only in isolated cases.
22. Unusual Bochdalek hernia in puerperium
- Author
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Šenkyrik, M., Lata, J., Husová, L., Díte, P., Petr Husa, Horálek, F., and Neubauer, J.
23. Bacterial infection and acute bleeding from upper gastrointestinal tract in patients with liver cirrhosis
- Author
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Husová, L., Lata, J., Petr Husa, Senkyrík, M., Juránkova, J., and Díte, P.
24. Relationship between K-ras mutation and the expression of p21 WAF1/CIP1 and p53 in chronic pancreatitis and pancreatic adenocarcinoma
- Author
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Marketa Hermanova, Lukáš, Z., Kroupová, Z., Kleibl, Z., Novotný, J., Nenutil, R., Pazourková, M., Brázdil, J., Křen, L., and Díte, P.
25. Frequency of representative single nucleotide polymorphisms associated with inflammatory bowel disease in the Czech Republic and Slovak Republic
- Author
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Jan Hošek, Bartosová L, Gregor P, Kolorz M, Díte P, Bátovský M, and Bartos M
- Subjects
Adult ,Male ,Slovakia ,Genotype ,Receptors, CCR5 ,Nod2 Signaling Adaptor Protein ,Middle Aged ,Intercellular Adhesion Molecule-1 ,Polymorphism, Single Nucleotide ,Crohn Disease ,Gene Frequency ,Mutation ,Humans ,Colitis, Ulcerative ,Female ,Genetic Predisposition to Disease ,Czech Republic - Abstract
Involvement of genetic factors in the aetiology of inflammatory bowel disease (IBD) has been known for a long time. Our aim was to investigate the prevalence of polymorphisms in NOD2, ICAM-1 and CCR5 genes in Czech and Slovak patients with IBD in comparison with healthy controls. The frequency of well-known mutations (R702W, G908W and 1007fs in the NOD2 gene; K469E in the ICAM-1 gene, and Delta32 in the CCR5 gene) involved in IBD was tested in 45 patients with CD and 22 patients with UC. The allele frequency of these mutations was determined and genotype-phenotype correlation was specified. Isolated DNA was genotyped, and allele frequency was counted and statistically verified. Significant differences between the healthy control group and CD patients were observed in mutation 1007fs of the NOD2 gene (P = 0.0203). We also associated allele E469 of the ICAM-1 gene with CD (P = 0.0024). No significant association between other alleles and CD was found, and no gene variation was linked to UC. The number of mutations and mutated genes was higher among patients with CD than among patients with UC. Our results support previous findings about participation of mutations of NOD2 and ICAM-1 genes in IBD. We confirmed that both CD and UC are polygenic diseases with a genedosage effect. This observation strengthens the opinion that genetic factors play a more important role in CD than in UC.
26. Proliferative activity in pancreatic intraepithelial neoplasias of chronic pancreatitis resection specimens: Detection of a high-risk lesion
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Hermanová M, Rudolf Nenutil, Kren L, Feit J, Pavlovský Z, and Díte P
- Subjects
Pancreatic Neoplasms ,Ki-67 Antigen ,Pancreatectomy ,Pancreatitis ,Duodenum ,Risk Factors ,Carcinoma ,Chronic Disease ,Antibodies, Monoclonal ,Humans ,Immunohistochemistry - Abstract
Patients with chronic pancreatitis have a markedly increased risk of pancreatic cancer compared with general population. Mechanism of the increased risk is not completely known. The current progression model for pancreatic ductal adenocarcinoma proposes the progression from normal ductal epithelium through a series of lesions called pancreatic intraepithelial neoplasias (PanINs) to invasive cancer. These lesions are frequently seen in chronic pancreatitis tissue. Proliferative activity in PanINs of chronic pancreatitis tissue has not been separately studied using the current nomenclature. Our study included 36 chronic pancreatitis resection specimens. A total number of 106 PanINs found within 32 resection specimens was histologically graded and then immunolabeled using a monoclonal antibody against Ki-67 that is expressed in dividing cells. The Ki-67 labeling indices in the increasing grades of PanINs were counted with following results: PanIN-1A, 0.77%; PanIN-1B, 3.26%; PanIN-2, 14.68%; and PanIN-3, 25.4%. The difference in Ki-67 labeling indices among these types of lesions was statistically significant (p0.001, t-test). These results correlate with known genetic alterations found in chronic pancreatitis, especially with p16 inactivation that was recently described in PanINs arising in patients with chronic pancreatitis. Moreover, our findings support the currently accepted pancreatic progression model and Ki-67 immunohistochemistry might represent an efficient tool for an identification of a high-risk lesion.
27. Differentiating autoimmune pancreatitis from pancreatic cancer.
- Author
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Díte P, Uvírová M, Bojková M, Novotný I, Dvorácková J, Kianicka B, Nechutová H, Dovrtelová L, Floreánová K, and Martínek A
- Subjects
- Biomarkers blood, Biopsy, Diagnosis, Differential, Endosonography, Glucocorticoids therapeutic use, Humans, Jaundice immunology, Magnetic Resonance Imaging, Pancreatic Neoplasms blood, Pancreatic Neoplasms complications, Pancreatitis blood, Pancreatitis complications, Pancreatitis drug therapy, Tomography, X-Ray Computed, Treatment Outcome, Pancreatic Neoplasms, Antigens, Tumor-Associated, Carbohydrate blood, Autoimmunity, Immunoglobulin G blood, Immunologic Factors blood, Jaundice etiology, Pancreatic Neoplasms diagnosis, Pancreatitis diagnosis, Pancreatitis immunology
- Abstract
Differential diagnosis between autoimmune pancreatitis (AIP) and pancreatic cancer can be very difficult. The main clinical symptoms in patients with autoimmune pancreatitis are jaundice, weight loss, abdominal pain and new onset of diabetes mellitus. Unfortunately, the same symptoms could be observed in patients with pancreatic carcinoma too. Imaging methods as computed tomography (CT) scan, magnetic resonance imaging (MRI) and endosonography (EUS); together with serological examination (IgG4 and Ca 19-9) play the important role in differentiation autoimmune pancreatitis from pancreatic cancer. Extrapancreatic findings are distinctive in patients with autoimmune pancreatitis. In some cases the pancreatic biopsy is indicated, mainly in patients with focal or multifocal form of autoimmune pancreatitis. Response to steroids (decreased pancreatic or extrapancreatic lesion or damage) is distinctive to AIP. In clinical practice, CT scan seems to be the most reasonable tool for examining the patients with obstructive jaundice with or without present pancreatic mass. Stratification the patients with possible AIP versus pancreatic cancer is important. In patients with AIP it may avoid pancreatic resection, as well as incorrect steroid treatment in patients with pancreatic carcinoma.
- Published
- 2014
28. [Endoscopic retrograde cholangiography with a single-balloon enteroscope in patients with Roux-en-Y hepatico jejunal anastomosis].
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Díte P
- Subjects
- Female, Humans, Male, Anastomosis, Roux-en-Y, Cholangiopancreatography, Endoscopic Retrograde methods, Hepatic Duct, Common surgery, Jejunum surgery
- Published
- 2012
29. [Chronic pancreatitis in 2011].
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Díte P, Trna J, Novotný I, Floreanová K, Nechutová H, and Geryk E
- Subjects
- Humans, Pancreatitis, Chronic diagnosis, Pancreatitis, Chronic etiology, Pancreatitis, Chronic therapy
- Abstract
The incidence of chronic pancreatitis grows slowly but steadily. At present, alcohol is the most frequent risk factor, although the new forms of so called non-alcoholic chronic pancreatitis, such as genetically induced pancreatitis and its autoimmune variety, are carefully watched. Alcohol consumption continues to be most closely associated with the disease, though it is no more than a risk factor and other aspects, e.g., genetic predisposition, are prerequisite to the disease development. Imaging methods play a fundamental role in diagnosing the disease; non-invasive magnetic resonance and CT, invasive but safe endosonography, and diagnostically rarely used ECRP that, because of its invasive nature, is currently predominantly used for therapeutic purposes. Genetic markers are also exploited, including CFTR mutation, SPINK 1 and PRRS 1 gene, immunoglobulin G4 in the autoimmune form of the disease as well as, alternatively, pancreatic biopsy. Disease symptoms, i.e., pancreatic malabsorption (enzymes with high lipase content) and pancreatic pain are treated conservatively, with paracetamol as the first line therapy for pain followed, if necessary, by so called synaptic analgesics. Alternatively, endoscopic techniques (drainage) or surgery (drainage and resection) are applied. Hereditary and non-hereditary chronic pancreatitis is among the risk factors for pancreatic cancer and thus patients with these diseases should be closely followed up.
- Published
- 2011
30. Endoscopic approach in diagnosis and treatment of biliary complications after laparoscopic cholecystectomy.
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Kianicka B, Díte P, Piskac P, Korbicka J, Vlcek P, and Zák J
- Subjects
- Adult, Aged, Bile Duct Diseases therapy, Choledocholithiasis diagnosis, Choledocholithiasis therapy, Female, Humans, Male, Middle Aged, Retrospective Studies, Bile Duct Diseases diagnosis, Cholangiopancreatography, Endoscopic Retrograde methods, Cholecystectomy, Laparoscopic adverse effects
- Abstract
Background/aims: The aim of this retrospective study is to follow the main parameters such as the success of performing diagnostic endoscopic retrograde cholangiopancreatography (ERCP) and to determine the effectiveness and morbidity of therapeutic ERCP., Methodology: The study of the group took 12 years (January 1997-December 2008). The paper assesses in retrospect 138 patients who underwent laparoscopic cholecystectomy (LCE). Signs leading to the suspicion of possible biliary complications (BC) after previous LCE appeared in these patients in the postoperative period, indicating the performance of ERCP., Results: Diagnostic ERCP was successful in all 138 patients (i.e. in 100% of cases). There were normal ERCP results in 8 patients and pathological results in the sense of some of the BC in the remaining 130 patients. Endoscopic therapy was performed after diagnostic ERCP in 115 of 130 patients with proved BC. Therapeutic ERCP was absolutely successful in altogether 111 of 130 patients (85.38%) with BC after LCE., Conclusions: The success rate of therapeutic ERCP in our group was 85.38%. Morbidity in relation to therapeutic ERCP was 4.2%. ERCP appears to be highly effective diagnostic and primarily therapeutic method in solving BC after LCE.
- Published
- 2011
31. [Autoimmune pancreatitis and IgG-positive sclerosing cholangitis].
- Author
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Díte P, Novotný I, Lata J, Růzicka M, Geryk E, and Kianicka B
- Subjects
- Autoimmune Diseases complications, Autoimmune Diseases diagnosis, Cholangitis, Sclerosing complications, Cholangitis, Sclerosing immunology, Cholangitis, Sclerosing therapy, Humans, Pancreatitis complications, Pancreatitis therapy, Autoimmune Diseases therapy, Cholangitis, Sclerosing diagnosis, Immunoglobulin G analysis, Pancreatitis diagnosis
- Abstract
Sclerosing cholangitis is a heterogenous disease. Sclerosing cholangitis with an unknown cause is abbreviated PSC. PSC affects extra- as well as intra-hepatic bile ducts and since this is a permanently progressing fibrous condition, it leads to liver cirrhosis. The disease is often associated with a development of cholangocarcinoma and idiopathic intestinal inflammation. Causal therapy does not exist; liver transplantation is indicated. IgG4 cholangitis differs from PSC in a number of features. This form is, unlike PSC, linked to autoimmune pancreatitis (AIP) as well as other IgG4 sclerosing diseases. Anatomically, distal region of ductus choledochus is most frequently involved. Icterus is, unlike in PSC, a frequent symptom of AIP. There also is a distinctive histological picture--significant lymphoplasmatic infiltration of the bile duct wall with abundance of IgG4 has been described, lymphoplasmatic infiltration with fibrosis in the periportal area and the presence of obliterating phlebitis is also typical. However, intact biliary epithelium is a typical feature. IgG4 can be diagnosed even without concurrent presence of AIP. IgG4 sclerosing cholangitis is a condition sensitive to steroid therapy. At present, there is no doubt that IgG4 sclerosing cholangitis is a completely different condition to primary sclerosing cholangitis. From the clinical perspective, these diseases should be differentiated in every clinician's mind as (a) AIP is treated with corticosteroids and not with an unnecessary surgery, (b) IgG4 sclerosing cholangitis is mostly successfully treated with corticosteroids and the disease is not, unlike PSC, a risk factor for the development of cholangiocarcinoma.
- Published
- 2011
32. [Pancreatic cancer--association with diabetes mellitus and smoking].
- Author
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Díte P, Trna J, Belobrádková J, Novotný I, Hermanová M, Vlcková P, Klímová K, Kianicka B, Lemine A, Liberda M, and Geryk E
- Subjects
- Aged, Female, Humans, Male, Middle Aged, Risk Factors, Adenocarcinoma etiology, Diabetes Mellitus, Type 2 complications, Pancreatic Neoplasms etiology, Smoking adverse effects
- Abstract
Introduction: Pancreatic cancer is a disease with rather poor prognosis. This can be explained, among other reasons, by unusually aggressive course of the tumour growth and, in the majority of cases, late, and thus further treatment limiting, diagnosis. In addition, no effective screening programme for pancreatic cancer is available and thus identification of risk factors associated with the development of pancreatic cancer represents a possible approach to diagnosing early stages of the disease. Smoking represents a general and diabetes mellitus a specific risk factor for pancreatic cancer. The aim of our prospective study in pancreatic cancer patients was to identify patients with diabetes mellitus and divide these into smokers and non-smokers--in association with the diagnosis of pancreatic carcinoma., Materials and Methods: We included 83 patients, 50 men and 33 women, with pancreatic cancer who were divided into 3 groups--non-smokers with diabetes mellitus, smokers and smokers with diabetes mellitus; the mean age was 64.2 years in male and 59.8 years in female patients. Pancreatic cancer was confirmed histomorphologically from pancreatic biopsies or a histology of pancreatic tissue obtained during a surgery., Results: Pancreatic cancer was diagnosed after 3 or more years in patients with diabetes mellitus, the majority of diagnoses in smokers were made within the first year from the first dyspeptic symptoms. We found that the proportion of patients with subsequent diagnosis of pancreatic cancer increased with the number of cigarettes smoked per day (33.3% up to 10 cigarettes per day and 66.5% over 10 cigarettes per day). The highest incidence of pancreatic cancer, in 42 persons (50.6%), was associated with concurrent diabetes and smoking., Conclusion: Pancreatic cancer was identified in 24% of patients with diabetes mellitus, 25.3% of smokers with no diabetes and in more than 50% of smokers with diabetes mellitus. We assume that smoking is an independent risk factor for pancreatic cancer induction and it importantly increases the risk of pancreatic cancer in patients with diabetes mellitus.
- Published
- 2011
33. [Immunoglobulin G4-associated cholangitis].
- Author
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Díte P, Husová L, Lukás Z, Precechtelová M, and Stepánková S
- Subjects
- Diagnosis, Differential, Humans, Male, Young Adult, Autoimmune Diseases diagnosis, Cholangitis, Sclerosing diagnosis, Immunoglobulin G blood
- Abstract
Autoimmune LgG4- associated cholangitis is a new entity among the liver and biliary tree disorders, classified among the so-called IgG4-related diseases. Even though prognosis of this disease is unclear, this type of sclerosing cholangitis is not being linked to a carcinoma. Clinical and laboratory data differ slightly from the findings associated with the usual primary sclerosing cholangitis and it is mainly the high IgG4 level and hyperbilirubinaemia that supports the diagnosis ofautoimmune disease. Unlike primary sclerosing cholangitis, this disease is not associated with a malignant prognosis and steroids represent an effective treatment. Combination of steroids with azathioprin is a possible alternative in case of a relapse. Patient's response to steroid therapy is a diagnosis-supporting criterion. This disease should always be considered as part of differential diagnosis of primary sclerosing cholangitis, especially when autoimmune aberrations or other autoimmune diseases are present. Long-term evaluations of these patients are so far lacking and thus studies on larger patient samples are required.
- Published
- 2010
34. [Chronic pancreatitis and the skeleton].
- Author
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Dujsíková H, Novotný I, Tomandl J, and Díte P
- Subjects
- Adult, Bone Density, Bone Diseases, Metabolic diagnosis, Exocrine Pancreatic Insufficiency complications, Humans, Middle Aged, Young Adult, Bone Diseases, Metabolic etiology, Pancreatitis, Chronic complications
- Abstract
The aim of our work was to determine the incidence of bone demineralization in patients with chronic pancreatitis, following the relation between the funcionality of the pancreatic tissue and etiological factors in the development of osteopathy and calciophosphate metabolism. Prospectivelly, during 1 year we followed 55 patients with chronic pancreatitis of different etiology verified by endoultrasound. Patients with other possible cause of osteopathy were not included in the group. In the following of calciophosphate metabolism we determined different biochemical parameters and we measured the bone mass with densitometry in standard locations. In the patients that we followed we managed to show high proportion (43.7%) of bone demineralization, however, no relation between the bone demineralization and the grade of chronic pancreatitis or the operation of pancreas was proved. Vitamin D deficiency has a significantly negative impact on bone metabolism, which is potentiated by pancreatic insufficiency and long-time alcohol abuse.
- Published
- 2010
35. [Contribution to differential diagnosis of chronic abdominal pain].
- Author
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Díte P and Kianicka B
- Subjects
- Diagnosis, Differential, Esophageal Diseases complications, Esophageal Diseases diagnosis, Humans, Pancreatic Diseases complications, Pancreatic Diseases diagnosis, Peptic Ulcer complications, Peptic Ulcer diagnosis, Abdominal Pain etiology
- Abstract
Differential diagnosis of abdominal pain is a complex area of internal medicine. The present paper discusses possible aetiology together with characterisation of some other signs, pain localisation, its propagation and diagnosis. The approach to differential diagnosis of abdominal pain must always be comprehensive and span from targeted anamnesis to physical examination of the abdomen and rational application of available, mainly imaging and endoscopic methods. Therefore, we present the most frequent aetiologies of functional and organic impairments ofthe oesophagus, intestines and pancreatic and biliary area, including possible extra-abdominal causes of abdominal pain. It is emphasised that abdominal pain should always be carefully investigated and analysed in order to prevent major mistakes and possible harm to our patients.
- Published
- 2010
36. Role of imaging methods in diagnosis of acute pancreatitis.
- Author
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Válek V, Kala Z, and Díte P
- Subjects
- Humans, Pancreatitis, Acute Necrotizing classification, Pancreatitis, Acute Necrotizing complications, Pancreatitis, Acute Necrotizing radiotherapy, Diagnostic Imaging methods, Pancreatitis, Acute Necrotizing diagnosis
- Abstract
Diagnosis and treatment of acute pancreatitis is a complex interdisciplinary team problem. Without knowledge of classification and the current opinion of other experts on this disease, the radiologist cannot be an adequate partner in this team. Nonetheless, the radiologist has a very important position, primarily 'thanks to' computed tomography (CT) in diagnosis and fading of the disease and the possibilities offered by minimally invasive treatment of early and late complications of this disease. A turning point from the viewpoint of diagnosing acute pancreatitis was first marked by Balthazar's classification and then establishing the CTSI (severity index for the disease based on CT findings), proposed by Balthazar as well. Radiologists' increasingly more active approach to drainage of acute fluid collections and pseudocysts in patients with acute pancreatitis as well as some possibilities for percutaneous treatment of necroses has led to a reassessment of surgeons' attitudes. A persistent problem is the correct indication and timing of CT scans and the drainage itself. In their concise communication, the authors present data from the literature and summarize their own experience. They highlight the most common mistakes, especially in the indication and timing of individual methods. Finally, they present their views on a practical approach to the use of CT and percutaneous drainage in these patients., (Copyright (c) 2010 S. Karger AG, Basel.)
- Published
- 2010
- Full Text
- View/download PDF
37. Autoimmune pancreatitis--recent advances.
- Author
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Novotný I, Díte P, Lata J, Nechutová H, and Kianicka B
- Subjects
- Adult, Autoimmune Diseases classification, Autoimmune Diseases epidemiology, Autoimmune Diseases pathology, Female, Humans, Incidence, Male, Middle Aged, Pancreatitis classification, Pancreatitis epidemiology, Pancreatitis pathology, Autoimmune Diseases complications, Pancreatitis complications
- Abstract
Autoimmune pancreatitis (AIP) is recognized as a distinct clinical entity, identified as a chronic inflammatory process of the pancreas in which the autoimmune mechanism is involved. Clinically and histologically, AIP has two subsets: type 1--lymphoplasmatic sclerosing pancreatitis with abundant infiltration of the pancreas and other affected organs with immunoglobulin G4-positive plasma cells, and type 2--duct centric fibrosis, characterized by granulocyte epithelial lesions in the pancreas without systemic involvement. In the diagnosis of AIP, two diagnostic criterions are used--the HISORt criteria and Asian Diagnostic Criteria. In the differential diagnosis, the pancreatic cancer must be excluded by endosonographically guided pancreatic biopsy. Typical signs of AIP are concomitant disorders in other organs (kidney, liver, biliary tract, salivary glands, colon, retroperitoneum, prostate). Novel clinicopathological entity was proposed as an 'IgG4-related sclerosing disease' (IgG4-RSC). Extensive IgG4-positive plasma cells and T lymphocyte infiltration is a common characteristics of this disease. Recently, IgG4-RSC syndrome was extended to a new entity, characterized by IgG4 hypergammaglobulinemia and IgG4-positive plasma cell infiltration, this being considered an expression of a lymphoproliferative disease, 'IgG4-positive multiorgan lymphoproliferative syndrome'. This syndrome includes Mikulicz's disease, mediastinal fibrosis, autoimmune hypophysitis, and inflammatory pseudotumor--lung, liver, breast. In the therapy of AIP, steroids constitute first-choice treatment. High response to the corticosteroid therapy is an important diagnostic criterion. In the literature, there are no case-control studies that determine if AIP predisposes to pancreatic cancer. Undoubtedly, AIP is currently a hot topic in pancreatology., (Copyright (c) 2010 S. Karger AG, Basel.)
- Published
- 2010
- Full Text
- View/download PDF
38. Preface. Diagnosis and therapy of pancreatic diseases is still a gastroenterological challenge.
- Author
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Díte P
- Subjects
- Cystic Fibrosis Transmembrane Conductance Regulator genetics, Humans, Pancreatic Diseases etiology, Pancreatic Diseases genetics, Pancreatitis, Chronic classification, Pancreatitis, Chronic genetics, Pancreatitis, Chronic immunology, Pancreatitis, Chronic pathology, Gastroenterology, Pancreatic Diseases diagnosis, Pancreatic Diseases therapy
- Published
- 2010
- Full Text
- View/download PDF
39. [Endoscopic diagnostics and management of pancreatic-biliary disorders in patients after Billroth II gastric resection].
- Author
-
Kianicka B, Díte P, and Piskac P
- Subjects
- Aged, Female, Follow-Up Studies, Humans, Male, Biliary Tract Diseases diagnosis, Biliary Tract Diseases surgery, Cholangiopancreatography, Endoscopic Retrograde, Gastroenterostomy, Pancreatic Diseases diagnosis, Pancreatic Diseases surgery
- Abstract
Aims of the Study: The aim of this retrospective study was to analyse diagnostic and therapeutic success of endoscopic retrograde cholangiopancreatography (ERCP) in our sample of patients following Billroth II gastric resection, where, due to significantly modified anatomic ratios, this surgery represents a specific and often extremely difficult technical problem when performing ERCP., Materials and Methodology: The sample was followed up for 13 years (November 1994-December 2007). The data on 112 patients after Billroth II gastric resection were assessed retrospectively; indications for ERCP included cholestasis in 92 patients, acute biliary pancreatitis in 12 patients, acute cholangitis in 6 patients and suspected bile leak following laparoscopic cholecystectomy (LCE) in 2 patients., Results: Cannulation success during ERCP in the 112 patients following Billroth II gastric resection was 90.2% (i.e. 101 of the 112 patients). Normal ERCP finding was recorded in 4 patients. The remaining 97 patients had pathological results on ERCP (choledocholitiasis was found in 78 patients, malignant biliary stenosis in 14, benign biliary stenosis in 3 a bile leak following LCE in 2). Endoscopic treatment was initiated immediately after diagnostic ERCP in all these 97 patients, the initial step was in all cases endoscopic papillotomy using one of the special papillotomes (diathermy wire). Overall, therapeutic ERCP was completely successful in 83 of the 97 patients (85.6% of 97) in whom the originally endoscopic treatment had been initiated., Conclusions: ERCP following Billroth II gastric resection is, due to modified post-surgery anatomy, markedly more challenging then the conventional procedure. Availability of a variety of tools as well as, understandably, extensive experience and skill of an endoscopist are prerequisite to ERCP success in these patients. Correctly performed ERCP in patients following Billroth II gastric resection is a highly effective and safe method for diagnostics and, in particular, treatment of pancreatic-biliary diseases, in which similar success as under standard anatomic conditions can be achieved.
- Published
- 2009
40. Frequency of representative single nucleotide polymorphisms associated with inflammatory bowel disease in the Czech Republic and Slovak Republic.
- Author
-
Hosek J, Bartosová L, Gregor P, Kolorz M, Díte P, Bátovský M, and Bartos M
- Subjects
- Adult, Czech Republic, Female, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Mutation, Slovakia, Colitis, Ulcerative genetics, Crohn Disease genetics, Gene Frequency, Intercellular Adhesion Molecule-1 genetics, Nod2 Signaling Adaptor Protein genetics, Polymorphism, Single Nucleotide, Receptors, CCR5 genetics
- Abstract
Involvement of genetic factors in the aetiology of inflammatory bowel disease (IBD) has been known for a long time. Our aim was to investigate the prevalence of polymorphisms in NOD2, ICAM-1 and CCR5 genes in Czech and Slovak patients with IBD in comparison with healthy controls. The frequency of well-known mutations (R702W, G908W and 1007fs in the NOD2 gene; K469E in the ICAM-1 gene, and Delta32 in the CCR5 gene) involved in IBD was tested in 45 patients with CD and 22 patients with UC. The allele frequency of these mutations was determined and genotype-phenotype correlation was specified. Isolated DNA was genotyped, and allele frequency was counted and statistically verified. Significant differences between the healthy control group and CD patients were observed in mutation 1007fs of the NOD2 gene (P = 0.0203). We also associated allele E469 of the ICAM-1 gene with CD (P = 0.0024). No significant association between other alleles and CD was found, and no gene variation was linked to UC. The number of mutations and mutated genes was higher among patients with CD than among patients with UC. Our results support previous findings about participation of mutations of NOD2 and ICAM-1 genes in IBD. We confirmed that both CD and UC are polygenic diseases with a genedosage effect. This observation strengthens the opinion that genetic factors play a more important role in CD than in UC.
- Published
- 2008
41. [Endoscopic diagnosis and treatment of biliary complications after laparoscopic cholecystectomy].
- Author
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Kianicka B, Díte P, and Suskevic I
- Subjects
- Bile Duct Diseases etiology, Female, Humans, Male, Middle Aged, Bile Duct Diseases diagnosis, Cholangiopancreatography, Endoscopic Retrograde, Cholecystectomy, Laparoscopic adverse effects
- Abstract
Objective of Study: The main parameters studied in this retrospective study were the success of diagnoses carried out using endoscopic retrograde cholangiopancreatography (ERCP), the ability of ERCP to precisely determine the cause of complications and the effectiveness and morbidity of therapeutic ERCP., Materials and Method: the study covers a period of 7 years (January 1997-December 2003). The study retrospectively reviewed the histories of 92 patients who underwent laparoscopic cholecystectomy (LCE) and subsequently developed symptoms suggesting possible biliary complications (BC) from previous LCE, and indicating the performance of ERCP., Results: diagnostic ERCP was successful for all 92 patients (i.e. in 100% of cases). In 5 patients the ERCP found normal conditions. In the remaining 87 patients, the ERCP found pathological conditions corresponding to some form of biliary complication. Choledocholithiasis was detected in 59 patients, bile leakage from the cystic duct stump was found in 11 patients, bile leakage from the extrahepatic bile duct was found in 4 patients, biliary stenosis in the common hepatic duct was found in 5 cases and 8 patients had blockages of the extrahepatic bile duct. 10 patients out of 87 received only diagnostic ERCP and all 10 underwent surgery immediately following diagnosis. 77 out of 87 patients with established BC underwent endoscopic therapy after diagnostic ERCP. Therapeutic ERCP was entirely successful for 73 patients out of 87 with BC after LCE (83.92%), and did not require other modalities of treatment such as surgical or transhepatic procedures., Conclusions: In our sample the success rate for therapeutic ERCP was 83.92%. Morbidity relating to therapeutic ERCP was 3.9%. ERCP was shown to be highly effective in both diagnosing and treating BC after LCE.
- Published
- 2007
42. [Endoscopic changes in the stomach and duodenal mucosa caused by minidose acetylsalicylic acid therapy and their prevention].
- Author
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Novotný I, Díte P, Kunovská M, and Münzová H
- Subjects
- Adult, Aged, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Anti-Ulcer Agents administration & dosage, Aspirin administration & dosage, Duodenum pathology, Female, Gastric Mucosa pathology, Humans, Intestinal Mucosa pathology, Male, Middle Aged, Omeprazole administration & dosage, Peptic Ulcer chemically induced, Peptic Ulcer prevention & control, Proton Pump Inhibitors administration & dosage, Anti-Inflammatory Agents, Non-Steroidal adverse effects, Aspirin adverse effects, Duodenum drug effects, Endoscopy, Gastrointestinal, Gastric Mucosa drug effects, Intestinal Mucosa drug effects
- Abstract
Minidose acetylsalicylic acid (ASA) administration is a significant risk factor for changes in the stomach and duodenal mucosa also in persons whose anamnesis does not indicate any previous symptoms of stomach disease or any other risk factor. One month ASA minidose therapy provoked changes in the stomach and duodenal mucosa in 43.7% of persons receiving the therapy for cardiologic or neurologic indications. The changes primarily involved erosion and were mainly located on the stomach mucosa, without signs of active bleeding. If ASA minidose therapy was administered for 1 month together with the proton pump inhibitor omeprazole, the rate of incidence of changes detected in the mucosa was statistically significantly lower, i.e. only 27.6 %, again without signs of fresh bleeding. The presence of Heliobacter pylori probably does not play a critical role; Heliobacter pylori was only detected in 34.1% of patients with changes in the mucosa. The persons who need ASA minidose therapy and especially those with risk factors must be secured by drugs with protective effect on the stomach and duodenal mucosa during ASA therapy, specifically in the form of proton pump inhibitors. Considering the benefit and complications of low-dose ASA therapy, it should not be indicated to persons with a low risk of cardiovascular or cerebrovascular complications and should be reserved for the treatment of high risk patients.
- Published
- 2007
43. [Lower dyspeptic syndrome. Recommended diagnostic and therapeutic procedures for general practitioners 2006].
- Author
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Seifert B, Lukás K, Charvátová E, Vojtísková J, Koudelka T, Hep A, Bures J, Jirásek V, and Díte P
- Subjects
- Humans, Irritable Bowel Syndrome diagnosis, Irritable Bowel Syndrome physiopathology, Irritable Bowel Syndrome therapy
- Abstract
Lower dyspeptic syndrome is a bowel disease manifesting namely with pain or sensation of abdominal discomfort and bowel movement problems (changes in the frequency and stool consistency). Symptoms include sensation of intraabdominal pressure and fullness, diarrhoea (with or without pain), sensation of incomplete defecation, constipation or bowel movement problems (with or without pain), irregular stool, collywobbles and bowel content flow (borborygia with spasms), meteorism, flatulency. Prevalence of the Irritable Bowel Syndrome in the European population is estimated to be 5 to 25 %. In the Czech Republic the total prevalence of dyspepsias is about 13 %. To the pathogenesis of the lower dyspeptic syndrome contribute: 1. abnormal motility, 2. abnormal visceral perception, 3. psychosocial factors, 4. luminal factors, 5. imbalance of neurotransmitters and/or intestinal bacteria and 6. possible inflammatory changes of the intestinal mucosa. Infectious diarrhoea is one of the causes. Functional bowel defects represent various combinations of chronic and recurrent symptoms from the digestive tract which cannot be explained by structural or biochemical abnormalities. Irritable bowel syndrome is a functional defect manifesting with abdominal pain, intestinal dyspepsia and compulsive defecations. Subtypes with typical symptomatology are characterized by circumstances which bring about pain and compulsive defecations (morning fractional defecation, postprandial defecation, debacles). Functional diarrhoea manifests with diarrhoea without intensive pain. Spastic obstipation manifests by abdominal pain, obstipation, compulsive defecations are absent, stool is cloddish, fragmented by spastic haustration, or it has a ribbon-form. Changes in the intestinal chemism include fermentative and putrefactive dyspepsia. Among the incomplete and atypical forms the isolated meteorism, irregular defecation, flatulency, abdominal pain--syndrome of the left or right epigastium or the syndrome of the right hypogastrium can be included. In patients with typical set of symptoms the working diagnose of the lower dyspeptic syndrome can be done by general practitioner. Complete history of the disease can reveal possible extra abdominal cause of dyspepsia, recognise alarming symptoms and consider circumstances elevating or lowering the probability of functional problems. Functional bowel problems have usually long-term character and represent clinically demanding challenge. Only few therapeutic regimens are successful and the therapy aimed at the abolishment of one symptom need not bring general improvement. For the clinical studies of the therapy of functional bowel problems significant placebo effect is typical. Quoad vitam prognosis is good, quoad sanationem it is rather doubtful.
- Published
- 2007
44. Factors participating in the development and mortality of variceal bleeding in portal hypertension--possible effects of the kidney damage and malnutrition.
- Author
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Lata J, Husová L, Juránková J, Senkyrík M, Díte P, Dastych M Jr, Dastych M, and Kroupa R
- Subjects
- Adult, Aged, Aged, 80 and over, Bilirubin blood, Esophageal and Gastric Varices blood, Female, Gastrointestinal Hemorrhage blood, Hematocrit, Humans, Hypertension, Portal blood, Hypertension, Portal mortality, Kidney Diseases blood, Liver Cirrhosis blood, Liver Cirrhosis mortality, Male, Malnutrition blood, Middle Aged, Prothrombin Time, Risk Factors, Survival Analysis, Urea blood, Esophageal and Gastric Varices etiology, Esophageal and Gastric Varices mortality, Gastrointestinal Hemorrhage etiology, Gastrointestinal Hemorrhage mortality, Hypertension, Portal etiology, Kidney Diseases complications, Liver Cirrhosis complications, Malnutrition complications
- Abstract
Background/aims: Acute bleeding from esophageal varices due to portal hypertension is a frequent and severe complication of liver cirrhosis. The development of esophageal varices as well as their rupture depends on the level of portal pressure; however, a number of other factors may play a negative role in the rise of bleeding and its prognosis., Methodology: The report presented has compared a set of 46 patients admitted to hospital for acute bleeding with 48 cirrhotics hospitalized for other reasons., Results: Bleeding patients had significantly higher level of nitrogenous substances (urea 14.1 mmol/L vs. 7.78 mmol/L, p < 0.01, creatinine 129.8 micromol/L vs. 106.04 micromol/L; p = 0.09). The disturbed renal function in itself probably does not increase the risk of bleeding, it may be rather considered a certain prognostic index of the portal hypertension degree. Bleeding patients had a lower level of total protein (60.7 g/L vs. 69.9 g/L; p < 0.01) with only slight insignificant decrease of albumin (26.64 g/L vs. 28.51 g/L). Cirrhotic patients are known to suffer from malnutrition and it is possible that malnutrition shares negatively and directly in the rise of bleeding., Conclusions: A prognostic index of mortality was a more conspicuous disorder of hepatic function (bilirubin 97.4 micromol/L vs. 57.4 micromol/L; p = 0.1; prolonged prothrombin time 1.99 INR vs. 1.56 INR; p = 0.01) and again the disorder of renal function (creatinine 166.7 micromol/L vs. 114.9 micromol/L; p = 0.09). Therefore, the maintenance of good renal function must be a component of complex therapy given to bleeding patients.
- Published
- 2006
45. [Effect of administration of Escherichia coli Nissle (Mutaflor) on intestinal colonisation, endo-toxemia, liver function and minimal hepatic encephalopathy in patients with liver cirrhosis].
- Author
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Lata J, Juránková J, Príbramská V, Fric P, Senkyrík M, Díte P, and Kroupa R
- Subjects
- Adult, Aged, Female, Hepatic Encephalopathy etiology, Humans, Liver Cirrhosis complications, Liver Cirrhosis microbiology, Liver Cirrhosis physiopathology, Male, Middle Aged, Endotoxins blood, Escherichia coli, Hepatic Encephalopathy psychology, Intestines microbiology, Liver physiopathology, Liver Cirrhosis therapy, Probiotics therapeutic use
- Abstract
The purpose of the study was to verify effects of Escherichia coli Nissle (Mutaflor) on intestinal colonisation, endotoxin levels, hepatic encephalopathy and liver function in patients with liver cirrhosis. The study involved 39 patients (22 taking Mutaflor and 17 taking placebo). Even though the number combination test showed extended reaction time in patients with described minimal hepatic encephalopathy the drop was not significant in the trend evaluation. However, the treated group displayed significant improvement of intestinal colonisation (p < 0.001) and a trend towards significant reduction of endotoxin levels on day 42 (p = 0.07) and improvement of liver function assessed with the Child-Pugh classification on days 42 and 84 (p = 0.06). Probiotic preparations can therefore represent a significant contribution to this group therapy.
- Published
- 2006
46. Variceal bleeding in portal hypertension: bacterial infection and comparison of efficacy of intravenous and per-oral application of antibiotics--a randomized trial.
- Author
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Lata J, Juránková J, Husová L, Senkyrík M, Díte P, Dastych M, Príbramská V, and Kroupa R
- Subjects
- Administration, Oral, Adult, Aged, Aged, 80 and over, Ampicillin therapeutic use, Anti-Bacterial Agents therapeutic use, Bacterial Infections drug therapy, Esophageal and Gastric Varices diagnosis, Female, Gastrointestinal Hemorrhage diagnosis, Humans, Injections, Intravenous, Liver Cirrhosis complications, Liver Cirrhosis, Alcoholic complications, Male, Middle Aged, Norfloxacin therapeutic use, Sulbactam therapeutic use, Treatment Outcome, Anti-Bacterial Agents administration & dosage, Bacterial Infections complications, Esophageal and Gastric Varices etiology, Gastrointestinal Hemorrhage etiology, Hypertension, Portal complications
- Abstract
Objective: To determine the prevalence of bacterial infection in patients admitted to hospital with variceal bleeding in comparison with patients with liver cirrhosis admitted because of another reason. To compare the effect of orally administered antibiotics vs. intravenous antibiotics., Methods: Bacteriological investigation of blood culture, urine, throat smear, perianal smear and ascites (polymorphonuclear count as well in ascites) was made in 46 cirrhotic patients admitted to hospital with variceal bleeding and 48 cirrhotic patients admitted because of another reason. Bleeders were treated endoscopically (sclerotization) and pharmacologically (terlipressin 1 mg every 4 h for 5 days), and were randomly allocated to the treatment with oral norfloxacin (25 patients) or intravenous ampicillin/sulbactam (21 patients). Early and late mortalities were evaluated., Results: The incidence of infection was high in both groups (63.0% bleeders vs. 54.2% controls), but bleeding patients more often had positive blood culture (17.3% vs. 8.6%) and statistically significantly more positive findings in the throat smears (36.9% vs. 17.3%, P=0.04), which gives the evidence of increased pathological colonization in these patients. No difference in survival was seen in patients with per-oral or intravenous administration of antibiotics., Conclusion: Bacterial infection was demonstrated in high percentage in patients with liver cirrhosis admitted to hospital. The administration of antibiotics is indicated in these patients. Intravenous application is probably of the same efficacy as per-oral one.
- Published
- 2005
- Full Text
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47. Bacterial infection and acute bleeding from upper gastrointestinal tract in patients with liver cirrhosis.
- Author
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Husová L, Lata J, Husa P, Senkyrík M, Juránková J, and Díte P
- Subjects
- Adult, Aged, Aged, 80 and over, Antibiotic Prophylaxis, Female, Gastrointestinal Hemorrhage microbiology, Humans, Hypertension, Portal complications, Hypertension, Portal microbiology, Liver Cirrhosis microbiology, Male, Middle Aged, Bacterial Infections complications, Gastrointestinal Hemorrhage etiology, Liver Cirrhosis complications
- Abstract
Background/aims: Acute bleeding from the upper gastrointestinal tract is a common and serious complication of liver cirrhosis. It is believed that bacterial infection may be the immediate cause of the bleeding and the latest meta-analyses show that bacterial infection is an independent predictive factor of the failure to stop bleeding., Methodology: The authors evaluated the presence of bacterial infection (blood, urine, throat and ascitic fluid) in 35 consecutive patients with liver cirrhosis and acute bleeding with portal hypertension and compared these results with a group of 35 patients with liver cirrhosis with portal hypertension without acute bleeding., Results: According to the results obtained, there is a statistically higher incidence of bacterial infection among patients with acute bleeding with portal hypertension (25 of 35 patients, 71%) than among patients with liver cirrhosis and portal hypertension without acute bleeding (14 of 35 patients, 40%, p < 0.01). The incidence of bacteriological findings in blood and throat samples is statistically higher in patients with acute bleeding as opposed to the control group (p < 0.05)., Conclusions: These results confirm the necessity of administering antibiotic prophylaxis to all cirrhotic patients with variceal bleeding, not just to those with confirmed infection or symptoms thereof.
- Published
- 2005
48. [Evaluation of gastroenterology procedures by general practitioners in the Czech Republic--contribution to interdisciplinary cooperation].
- Author
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Seifert B, Díte P, and Vojtisková J
- Subjects
- Adult, Data Collection, Female, Gastroenterology, Humans, Male, Middle Aged, Clinical Competence, Family Practice, Gastrointestinal Diseases diagnosis, Gastrointestinal Diseases therapy
- Abstract
Background: The understanding of different management strategies in primary and secondary care is important for cooperation between specialists and general practitioners in clinical practice. The Institut of General Practice at First Faculty of Medicine carried out a survey for gastroenterologists concerning their opinions on general practitioners and their current knowledge, competence and management of GI disorders as a contribution to interdisciplinary communication., Methods and Results: Questionnaires were sent to 552 gastroenterologists in the country. There was a response rate of 31% without any reminder, 170 questionnaires were included in a study. The most of gastroenterologists (92%) support practical guidelines development. There is an insufficient confidence that these guidelines are implemented in practice. Four from five gastroenterologists consider knowledge of their colleagues GPs in gastroenterology as average. In particular cases (irritable bowel syndrome, step up and step down approach) are specialists rather sceptic. There is a low support for the increase of GP competence in gastroenterology, as for urea breath test availibility, particularly in private gastroenterologists (p=0,04)., Conclusions: Results of the survey could facilitate the interdisciplinary communication in gastroenterology, contribute to CME programs development and may serve as an example for other specialities.
- Published
- 2005
49. [Factors participating in development of bleeding varices in portal hypertension. Part II: Possible impact of kidney damage and malnutrition, mortality].
- Author
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Lata J, Husová L, Juránková J, Senkyrík M, Díte P, Dastych Mj, Dastych M, and Kroupa R
- Subjects
- Adult, Aged, Aged, 80 and over, Esophageal and Gastric Varices physiopathology, Female, Gastrointestinal Hemorrhage mortality, Gastrointestinal Hemorrhage physiopathology, Humans, Male, Middle Aged, Prognosis, Survival Rate, Esophageal and Gastric Varices etiology, Gastrointestinal Hemorrhage etiology, Hypertension, Portal complications, Kidney physiopathology, Malnutrition complications
- Abstract
An acute bleeding from oesophageal varices as a result of portal hypertension is a frequent and serious complication of liver cirrhosis. The development of oesophageal varices and their rupture depends on the portal pressure. However, a range of other factors can contribute to a development of bleeding and its negative prognosis. A sample of 46 patients admitted for the acute bleeding has been compared to 48 cirrhosis patients hospitalised for other conditions in this work. There were significantly higher levels of nitrogenous matters in bleeding patients (urea 14.1 mmol/l vs. 7.78 mmol/l, p < 0.01, creatinine 129.8 micromol/l vs. 106.04 micromol/l, p = 0.09). Perhaps it can't be said that impaired renal functions alone increase the risk of bleeding. From this point of view they could rather be seen as definite prognostic markers of the degree of portal hypertension. Moreover, there was a decreased level of total proteins in bleeding patients (60.7 g/l vs. 69.9 g/l, p < 0.01) at a mild nonsignificant decrease of albumin (26.64 g/l vs. 28.51 g/l). Cirrhotic patients are known to suffer from malnutrition and there is a possibility that malnutrition can contribute to development of bleeding. A prognostic marker of mortality was a considerable impairment of liver function (bilirubin 97.4 micromol/l vs. 57.4 micromol/l; p = 0.1 and prolonged prothrombin time 1.99 INR vs. 1.56 INR; p = 0.09) and impaired kidney function (creatinine 166.7 micromol/l vs. 114.9 micromol/l, p = 0.09). Therefore a care of a good renal function must be a part of the complex care of bleeding patients.
- Published
- 2004
50. [Factors participating in development of bleeding varices in portal hypertension. Part I: bacterial infection and comparison of intravenous and peroral antibiotics effects--a randomised study].
- Author
-
Lata J, Juránková J, Husová L, Senkyrík M, Díte P, Dastych M, and Príbramská V
- Subjects
- Administration, Oral, Adult, Aged, Aged, 80 and over, Ampicillin administration & dosage, Bacterial Infections diagnosis, Bacterial Infections drug therapy, Esophageal and Gastric Varices complications, Female, Gastrointestinal Hemorrhage microbiology, Humans, Hypertension, Portal complications, Infusions, Intravenous, Liver Cirrhosis complications, Male, Middle Aged, Norfloxacin administration & dosage, Sulbactam administration & dosage, Anti-Bacterial Agents administration & dosage, Bacterial Infections complications, Esophageal and Gastric Varices microbiology, Gastrointestinal Hemorrhage etiology, Hypertension, Portal microbiology, Liver Cirrhosis microbiology
- Abstract
An acute bleeding from oesophageal varices as a result of portal hypertension is a frequent and at the same time serious complication of cirrhosis of the liver. One of factors influencing this bleeding can be a bacterial infection. Endotoxines can increase portal pressure and so participate in development of bleeding and simultaneously deteriorate a patient's prognosis. An antibiotic treatment is a part of a treatment algorithm, however what antibiotics to administer and in what manner is unclear. A group of 46 patients who were admitted to a hospital for an acute bleeding from varices has been compared in the study to 48 cirrhosis patients hospitalised for other reasons. An infection incidence was high in both groups (63.0 % vs. 54.2 %), bleeding patients had more often positive hemoculture (17.3 % vs. 8.6 %), and statistically significantly more often positive findings in throat swab culture (36.9 % vs. 17.3 %, p = 0.04) which is an evidence of an increased pathology colonisation of these patients. Bleeding patients were randomised for peroral norfloxacin administration (n = 25) or an intravenous administration of a combination of ampicilin and sulbactam (n = 21). There was no difference in survival of both groups. Due to a high number of bacterial infections antibiotics administration has been indicated in these patients. Intravenous administration is probably of the same effect as peroral administration.
- Published
- 2004
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