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6. Changes in the global hospitalisation burden of respiratory syncytial virus in young children during the COVID-19 pandemic: a systematic analysis

Author

Mrčela, Dina, Milić, Petra, Veljačić Visković, Daniela, Torres-Fernandez, David, Urchueguía, Arantxa, Díez-Domingo, Javier, Orrico-Sánchez, Alejandro, Walaza, Sibongile, Gottberg, Anne von, Reubenson, Gary, Dawood, Halima, Mekgoe, Omphile, Plessis, Mignon du, Baute, Neydis, Naby, Fathima, Keck, James W, Dobson, Jennifer, Hartman, Rachel, Sandoval, Marqia, Bressler, Sara S, Bruden, Dana, Karseladze, Irakli, Shchomak, Zakhar, Barreto, Rosário, Murunga, Nickson, Mutunga, Martin, Casalegno, Jean-Sebastien, Horvat, Come, Cong, Bingbing, Koç, Uğurcan, Bandeira, Teresa, Bassat, Quique, Bont, Louis, Chakhunashvili, Giorgi, Cohen, Cheryl, Desnoyers, Christine, Hammitt, Laura L, Heikkinen, Terho, Huang, Q Sue, Markić, Joško, Mira-Iglesias, Ainara, Moyes, Jocelyn, Nokes, D James, Ploin, Dominique, Seo, Euri, Singleton, Rosalyn, Wolter, Nicole, Fu Yung, Chee, Zar, Heather J, Feikin, Daniel R, Sparrow, Erin G, Nair, Harish, and Li, You

Published
2024
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12. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis

Author

Abram, Michael, Aerssens, Jeroen, Alafaci, Annette, Balmaseda, Angel, Bandeira, Teresa, Barr, Ian, Batinović, Ena, Beutels, Philippe, Bhiman, Jinal, Blyth, Christopher C, Bont, Louis, Bressler, Sara S, Cohen, Cheryl, Cohen, Rachel, Costa, Anna-Maria, Crow, Rowena, Daley, Andrew, Dang, Duc-Anh, Demont, Clarisse, Desnoyers, Christine, Díez-Domingo, Javier, Divarathna, Maduja, du Plessis, Mignon, Edgoose, Madeleine, Ferolla, Fausto Martín, Fischer, Thea K, Gebremedhin, Amanuel, Giaquinto, Carlo, Gillet, Yves, Hernandez, Roger, Horvat, Come, Javouhey, Etienne, Karseladze, Irakli, Kubale, John, Kumar, Rakesh, Lina, Bruno, Lucion, Florencia, MacGinty, Rae, Martinon-Torres, Federico, McMinn, Alissa, Meijer, Adam, Milić, Petra, Morel, Adrian, Mulholland, Kim, Mungun, Tuya, Murunga, Nickson, Newbern, Claire, Nicol, Mark P, Odoom, John Kofi, Openshaw, Peter, Ploin, Dominique, Polack, Fernando P, Pollard, Andrew J, Prasad, Namrata, Puig-Barberà, Joan, Reiche, Janine, Reyes, Noelia, Rizkalla, Bishoy, Satao, Shilpa, Shi, Ting, Sistla, Sujatha, Snape, Matthew, Song, Yanran, Soto, Giselle, Tavakoli, Forough, Toizumi, Michiko, Tsedenbal, Naranzul, van den Berge, Maarten, Vernhes, Charlotte, von Mollendorf, Claire, Walaza, Sibongile, Walker, Gregory, Li, You, Wang, Xin, Blau, Dianna M, Caballero, Mauricio T, Feikin, Daniel R, Gill, Christopher J, Madhi, Shabir A, Omer, Saad B, Simões, Eric A F, Campbell, Harry, Pariente, Ana Bermejo, Bardach, Darmaa, Bassat, Quique, Casalegno, Jean-Sebastien, Chakhunashvili, Giorgi, Crawford, Nigel, Danilenko, Daria, Do, Lien Anh Ha, Echavarria, Marcela, Gentile, Angela, Gordon, Aubree, Heikkinen, Terho, Huang, Q Sue, Jullien, Sophie, Krishnan, Anand, Lopez, Eduardo Luis, Markić, Joško, Mira-Iglesias, Ainara, Moore, Hannah C, Moyes, Jocelyn, Mwananyanda, Lawrence, Nokes, D James, Noordeen, Faseeha, Obodai, Evangeline, Palani, Nandhini, Romero, Candice, Salimi, Vahid, Satav, Ashish, Seo, Euri, Shchomak, Zakhar, Singleton, Rosalyn, Stolyarov, Kirill, Stoszek, Sonia K, von Gottberg, Anne, Wurzel, Danielle, Yoshida, Lay-Myint, Yung, Chee Fu, Zar, Heather J, and Nair, Harish

Published
2022
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13. Nirsevimab Effectiveness Against Severe RSV Infection in the Primary Care Setting.

Author

López-Lacort, Mónica, Muñoz-Quiles, Cintia, Mira-Iglesias, Ainara, López-Labrador, F. Xavier, Garcés-Sánchez, María, Escribano-López, Begoña, Zornoza-Moreno, Matilde, Pérez-Martín, Jaime Jesús, Alfayate-Miguelez, Santiago, Iofrío-De Arce, Antonio, Pastor-Villalba, Eliseo, Lluch-Rodrigo, José Antonio, Díez-Domingo, Javier, and Orrico-Sánchez, Alejandro

Published
2024
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14. Seasonality and Co‐Detection of Respiratory Viral Infections Among Hospitalised Patients Admitted With Acute Respiratory Illness—Valencia Region, Spain, 2010–2021.

Author

Shirreff, George, Chaves, Sandra S., Coudeville, Laurent, Mengual‐Chuliá, Beatriz, Mira‐Iglesias, Ainara, Puig‐Barberà, Joan, Orrico‐Sanchez, Alejandro, Díez‐Domingo, Javier, Opatowski, Lulla, and Lopez‐Labrador, F. Xavier

Subjects
SARS-CoV-2, VIRUS diseases, INFLUENZA viruses, PARAINFLUENZA viruses, DIAGNOSTIC use of polymerase chain reaction, RESPIRATORY syncytial virus, CORONAVIRUSES
Abstract

Background: Respiratory viruses are known to represent a high burden in winter, yet the seasonality of many viruses remains poorly understood. Better knowledge of co‐circulation and interaction between viruses is critical to prevention and management. We use > 10‐year active surveillance in the Valencia Region to assess seasonality and co‐circulation. Methods: Over 2010–2021, samples from patients hospitalised for acute respiratory illness were analysed using multiplex real‐time PCR to test for 9 viruses: influenza, respiratory syncytial virus (RSV), parainfluenza virus (PIV), rhino/enteroviruses (HRV/ENV), metapneumovirus (MPV), bocavirus, adenovirus, SARS‐CoV‐2 and non‐SARS coronaviruses (HCoV). Winter seasonal patterns of incidence were examined. Instances of co‐detection of multiple viruses in a sample were analysed and compared with expected values under a crude model of independent circulation. Results: Most viruses exhibited consistent patterns between years. Specifically, RSV and influenza seasons were clearly defined, peaking in December–February, as did HCoV and SARS‐CoV‐2. MPV, PIV and HRV/ENV showed less clear seasonality, with circulation outside the observed period. All viruses circulated in January, suggesting any pair had opportunity for co‐infection. Multiple viruses were found in 4% of patients, with more common co‐detection in children under 5 (9%) than older ages. Influenza co‐detection was generally observed infrequently relative to expectation, while RSV co‐detections were more common, particularly among young children. Conclusions: We identify characteristic patterns of viruses associated with acute respiratory hospitalisation during winter. Simultaneous circulation permits extensive co‐detection of viruses, particularly in young children. However, virus combinations appear to differ in their rates of co‐detection, meriting further study. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Pediatric Respiratory Hospitalizations in the Pre-COVID-19 Era: The Contribution of Viral Pathogens and Comorbidities to Clinical Outcomes, Valencia, Spain.

Author

Bosch Castells, Valérie, Mira-Iglesias, Ainara, López-Labrador, Francisco Xavier, Mengual-Chuliá, Beatriz, Carballido-Fernández, Mario, Tortajada-Girbés, Miguel, Mollar-Maseres, Joan, Puig-Barberà, Joan, Díez-Domingo, Javier, and Chaves, Sandra S.

Subjects
HOSPITAL care of children, VIRUS diseases, RESPIRATORY syncytial virus, VIRAL vaccines, POLYMERASE chain reaction
Abstract

Viral respiratory diseases place a heavy burden on the healthcare system, with children making up a significant portion of related hospitalizations. While comorbidities increase the risk of complications and poor outcomes, many hospitalized children lack clear risk factors. As new vaccines for respiratory viral diseases emerge, this study examined pediatric respiratory hospitalizations, focusing on viral etiology, complication rates, and the impact of comorbidities to guide future policy. Data were analyzed from eight pre-COVID influenza seasons (2011/2012–2018/2019) involving patients under 18 years hospitalized with respiratory complaints across 4–10 hospitals in Valencia, Spain. Respiratory specimens were tested for eight viral targets using multiplex real-time reverse-transcription polymerase chain reaction. Demographics, clinical outcomes, discharge diagnoses, and laboratory results were examined. Among the hospitalized children, 26% had at least one comorbidity. These children had higher rates of pneumonia, asthma exacerbation, and pneumothorax, and were twice as likely to require ICU admission, though mechanical ventilation and length of stay were similar to those without comorbidities. Respiratory syncytial virus (RSV) was the most common virus detected (23.1%), followed by rhinovirus/enterovirus (9.5%) and influenza (7.2%). Viral codetection decreased with age, occurring in 4.6% of cases. Comorbidities increase the risk of complications in pediatric respiratory illnesses, however, healthcare utilization is driven largely by otherwise healthy children. Pediatric viral vaccines could reduce this burden and should be further evaluated. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Incidence of Invasive and Noninvasive Pneumococcal Pneumonia Hospitalizations in People Aged ≥50 Years: Assessing Variability Across Denmark and Spain.

Author

López-Lacort, Mónica, Amini, Marzyeh, Emborg, Hanne-Dorthe, Nielsen, Jens, McDonald, Scott A, Valentiner-Branth, Palle, Díez-Domingo, Javier, and Orrico-Sánchez, Alejandro

Subjects
PNEUMOCOCCAL pneumonia, OLDER people, STREPTOCOCCUS pneumoniae, ANTIGEN analysis, SEXUAL dimorphism
Abstract

Determining pneumococcal pneumonia (PP) burden in the elderly population is challenging due to limited data on invasive PP (IPP) and, in particular, noninvasive PP (NIPP) incidence. Using retrospective cohorts of adults aged ≥50 years in Denmark (2 782 303) and the Valencia region, Spain (2 283 344), we found higher IPP hospitalization rates in Denmark than Valencia (18.3 vs 9/100 000 person-years [PY], respectively). Conversely, NIPP hospitalization rates were higher in Valencia (48.2 vs 7.2/100 000 PY). IPP and NIPP rates increased with age and comorbidities in both regions, with variations by sex and case characteristics (eg, complications, mortality). The burden of PP in adults is substantial, yet its true magnitude remains elusive. Discrepancies in clinical practices impede international comparisons; for instance, Valencia employed a higher frequency of urinary antigen tests compared to Denmark. Additionally, coding practices and prehospital antibiotic utilization may further influence these variations. These findings could guide policymakers and enhance the understanding of international disparities in disease burden assessments. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Risk of Cardiovascular Events After Influenza: A Population-Based Self-Controlled Case Series Study, Spain, 2011–2018.

Author

Muñoz-Quiles, Cintia, López-Lacort, Mónica, Urchueguía, Arantxa, Díez-Domingo, Javier, and Orrico-Sánchez, Alejandro

Subjects
ISCHEMIC stroke, DISEASE risk factors, INFLUENZA, HOSPITAL laboratories, PRIMARY care
Abstract

This study explores the relationship between influenza infection, both clinically diagnosed in primary care and laboratory confirmed in hospital, and atherothrombotic events (acute myocardial infarction and ischemic stroke) in Spain. A population-based self-controlled case series design was used with individual-level data from electronic registries (n = 2 230 015). The risk of atherothrombotic events in subjects ≥50 years old increased more than 2-fold during the 14 days after the mildest influenza cases in patients with fewer risk factors and more than 4-fold after severe cases in the most vulnerable patients, remaining in them more than 2-fold for 2 months. The transient increase of the association, its gradient after influenza infection, and the demonstration by 4 different sensitivity analyses provide further evidence supporting causality. This work reinforces the official recommendations for influenza prevention in at-risk groups and should also increase the awareness of even milder influenza infection and its possible complications in the general population. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Immunological response against SARS-CoV-2 following full-dose administration of Comirnaty® COVID-19 vaccine in nursing home residents

Author

Burgos, J.S., Meneu de Guillerna, R., Vanaclocha Luna, H., Burks, D.J., Cervantes, A., Comas, I., Díez-Domingo, J., Peiro, S., González-Candelas, F., Ferrer Albiach, C., Hernández-Aguado, I., Oliver Ramírez, N., Sánchez-Payá, J., Vento Torres, M., Zapater Latorre, E., Navarro, D., Albert, Eliseo, Burgos, Javier S., Peiró, Salvador, Salas, Dolores, Vanaclocha, Hermelinda, Giménez, Estela, Limón, Ramón, Alcaraz, María Jesús, Sánchez-Payá, José, Díez-Domingo, Javier, and Navarro, David

Published
2022
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21. Enterovirus D68 disease burden and epidemiology in hospital‐admitted influenza‐like illness, Valencia region of Spain, 2014–2020 influenza seasons.

Author

Mengual‐Chuliá, Beatriz, Tamayo‐Trujillo, Rafael, Mira‐Iglesias, Ainara, Cano, Laura, García‐Esteban, Sandra, Ferrús, Maria Loreto, Puig‐Barberà, Joan, Díez‐Domingo, Javier, López‐Labrador, F. Xavier, Carballido‐Fernández, Mario, Mollar‐Maseres, Juan, Tortajada‐Girbés, Miguel, Schwarz‐Chávarri, Germán, Gil‐Guillén, Vicente, Limón‐Ramírez, Ramón, Carbonell‐Franco, Empar, Belenguer‐Varea, Ángel, Carratalá‐Munuera, Concepción, and Tuells‐Hernández, José Vicente

Subjects
ENTEROVIRUS diseases, INFLUENZA, EPIDEMIOLOGY, RESPIRATORY infections, ADULTS, AMINO acids
Abstract

Enterovirus D68 (EV‐D68) is an emerging agent for which data on the susceptible adult population is scarce. We performed a 6‐year analysis of respiratory samples from influenza‐like illness (ILI) admitted during 2014‐2020 in 4‐10 hospitals in the Valencia Region, Spain. EV‐D68 was identified in 68 (3.1%) among 2210 Enterovirus (EV)/Rhinovirus (HRV) positive samples. Phylogeny of 59 VP1 sequences showed isolates from 2014 clustering in B2 (6/12), B1 (5/12), and A2/D1 (1/12) subclades; those from 2015 (n = 1) and 2016 (n = 1) in B3 and A2/D1, respectively; and isolates from 2018 in A2/D3 (42/45), and B3 (3/45). B1 and B2 viruses were mainly detected in children (80% and 67%, respectively); B3 were equally distributed between children and adults; whereas A2/D1 and A2/D3 were observed only in adults. B3 viruses showed up to 16 amino acid changes at predicted antigenic sites. In conclusion, two EV‐D68 epidemics linked to ILI hospitalized cases occurred in the Valencia Region in 2014 and 2018, with three fatal outcomes and one ICU admission. A2/D3 strains from 2018 were associated with severe respiratory infection in adults. Because of the significant impact of non‐polio enteroviruses in ILI and the potential neurotropism, year‐round surveillance in respiratory samples should be pursued. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Global burden of respiratory infections associated with seasonal influenza in children under 5 years in 2018: a systematic review and modelling study

Author

Nair, Harish, Campbell, Harry, Wang, Xin, Li, You, Chung, Alexandria, Rahi, Manveer, Abbas, Qalab, Ali, Asad, Bhutta, Zulfiqar A, Saeed, Bushra, Soofi, Sajid B, Yousafzai, Mohammad Tahir, Zaidi, Anita K, Amu, Alberta, Awini, Elizabeth, Azziz-Baumgartner, Eduardo, Baggett, Henry C, Chaves, Sandra S, Shang, Nong, Schrag, Stephanie J, Widdowson, Marc-Alain, Tempia, Stefano, Bassat, Quique, Lanaspa, Miguel, Acácio, Sozinho, Brooks, W Abdullah, Driscoll, Amanda, Knoll, Maria Deloria, O'Brien, Katherine L, Prosperi, Christine, Baqui, Abdullah H, Mullany, Luke, Byass, Peter, Cohen, Cheryl, von Gottberg, Anne, Hellferscee, Orienka, Treurnicht, Florette K, Walaza, Sibongile, Goswami, Doli, Rahman, Mustafizur, Connor, Nicholas E, El Arifeen, Shams, Echavarria, Marcela, Marcone, Débora N, Reyes, Noelia, Gutierrez, Andrea, Rodriguez, Ivan, Lopez, Olga, Ortiz, David, Gonzalez, Nathaly, Gentile, Angela, del Valle Juarez, Maria, Gordon, Aubree, Cutland, Clare, Groome, Michelle, Madhi, Shabir A, Nunes, Marta C, Nzenze, Susan, Heikkinen, Terho, Hirve, Siddhivinayak, Juvekar, Sanjay, Halasa, Natasha, Jara, Jorge H, Bernart, Chris, Katz, Mark A, Gofer, Ilan, Avni, Yonat Shemer, Khuri-Bulos, Najwa, Faori, Samir, Shehabi, Asem, Krishnan, Anand, Kumar, Rakesh, Amarchand, Ritvik, Contreras, Carmen L, de Leon, Oscar, Lopez, Maria R, McCracken, John P, Maldonado, Herberth, Samayoa, Antonio P, Gomez, Ana B, Lucero, Marilla G, Nillos, Leilani T, Lupisan, Socorro P, Nohynek, Hanna, Mira-Iglesias, Ainara, Puig-Barberà, Joan, Díez-Domingo, Javier, Gessner, Bradford D, Njanpop-Lafourcade, Berthe-Marie, Moïsi, Jennifer C, Tall, Haoua, Munywoki, Patrick K, Ngama, Mwanjuma, Nokes, D James, Omer, Saad B, Clark, Dayna R, Ourohiré, Millogo, Ali, Sié, Pascal, Zabré, Cheik, Bagagnan H, Caballero, Mauricio T, Libster, Romina, Polack, Fernando P, Rasmussen, Zeba A, Thomas, Elizabeth D, Baker, Julia M, Rath, Barbara A, Obermeier, Patrick E, Hassanuzzaman, MD., Islam, Maksuda, Islam, Mohammad S, Saha, Samir K, Panigrahi, Pinaki, Bose, Anuradha, Isaac, Rita, Murdoch, David, Nanda, Pritish, Qazi, Shamim A, Hessong, Danielle, Simőes, Eric AF, Sotomayor, Viviana, Thamthitiwat, Somsak, Chittaganpitch, Malinee, Dawood, Halima, Kyobutungi, Catherine, Wamukoya, Marylene, Ziraba, Abdhalah K, Yoshida, Lay-Myint, Yoshihara, Keisuke, Dand, Duc-Anh, Le, Minh-Nhat, Nicol, Mark P, Zar, Heather J, Broor, Shobha, Chadha, Mandeep, Madrid, Lola, Gresh, Lionel, Balmaseda, Angel, Kuan, Guillermina, Wairagkar, Niteen, Tapia, Milagritos D, Knobler, Stacey L, Barahona, Alfredo, Ferguson, Ericka, Schweiger, Brunhilde, Abdullah Brooks, W, Fasce, Rodrigo A, and Simões, Eric AF

Published
2020
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24. Feasibility of a hybrid clinical trial for respiratory virus detection in toddlers during the influenza season

Author

Muñoz-Ramírez, Soledad, Escribano-López, Begoña, Rodrigo-Casares, Vallivana, Vergara-Hernández, Carlos, Gil-Mary, Desamparados, Sorribes-Monrabal, Ignacio, Garcés-Sánchez, María, Muñoz-Del-Barrio, María-Jesús, Albors-Fernández, Ana-María, Úbeda-Sansano, María-Isabel, Planelles-Cantarino, María-Victoria, Largo-blanco, Ester-María, Suárez-Vicent, Eva, García-Rubio, Javier, Bruijning-Verhagen, Patricia, Orrico-Sánchez, Alejandro, and Díez-Domingo, Javier

Published
2021
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28. 2592. The Incidence Rate Of Pneumococcal Pneumonia In Two European Aging Adults Population Using Real-World Data

Author

López-lacort, Mónica, primary, Amini, Marzyeh, additional, Emborg, Hanne-Dorthe, additional, Nielsen, Jens, additional, Valentiner-Branth, Palle, additional, Winje, Brita Askeland, additional, Steens, Anneke, additional, McDonald, Scott A, additional, Johnson, Kelly D, additional, Savic, Miloje, additional, Díez-Domingo, Javier, additional, and Orrico-Sánchez, Alejandro, additional

Published
2023
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30. Enhancing global vaccine pharmacovigilance: Proof-of-concept study on aseptic meningitis and immune thrombocytopenic purpura following measles-mumps containing vaccination

Author

Kuli-Lito, Georgina, Kostaqi, Entela, Petrela, Elizana, Castellano, Vanesa E., Chiarvetti, Lucia, Falcó, Adriana, Gentile, Angela, Guirau, Karina, Carrega, Maria Eugenia Pérez, Rasjido, Susana, Testino, Sofía, Vizzotti, Carla, Buttery, Jim, Mcminn, Alissa, Quinn, Julie, Avendaño, Marcela, González, Marcela, Lagos, Rosanna, Maturana, Marcelo, Muñoz, Fernando, Saldaña, Adiela, Soza, Guillermo, Zhang, Tao, Zhang, Xiyan, Ding, Yunfang, Zhang, Jun, Alvarez-Olmos, Martha I., Sastoque, Luz Amparo, Mezerville, Marcela Hernández-de, Machado, Vicenta, Roverssi, Ileana, Camacho, Angélica Vargas, Luque, Marco Tulio, Mendoza, Liset, Ravi, Mandyam, Manjunath, V.G., Karimi, Abdollah, Ghanaie, Roxana Mansour, Seifi, Kimia, Shirvani, Fariba, Ashrafi, Mahmoud Reza, Parvaneh, Nima, Kochakzadeh, Leily, Mamishi, Sertareh, Kompani, Farzad, Eshaghi, Hamid, Pirmoazen, Vahideh, Aquije Hernández, Renne F., Díaz, Maria Esther Castillo, Mamani, Gladys Turpo, Thoon, Koh Cheng, Oh, Bee Khiam, Yelen, Cutland, Clare, Madhi, Shabir A., Groome, Michelle, Velaphi, Sithembiso, Izu, Alane, Diep, Linh, Hwinya, Cleopas, Pérez-Vilar, Silvia, Díez-Domingo, Javier, Martín-Navarro, Marian, Soriano-García, Esther, Tuells, Jose, Pande, Stephen Legesi, Alaroker, Florence, Amulen, Dorothy, Akareut, Margaret, Areto, Esther, Komo, Richard Samson, Quinto, Ogwang, Giachetto, Gustavo, Speranza, Noelia, Zunino, Carlos, Perez-Vilar, Silvia, Weibel, Daniel, Sturkenboom, Miriam, Black, Steven, Maure, Christine, Castro, Jose Luis, Bravo-Alcántara, Pamela, Dodd, Caitlin N., Romio, Silvana A., de Ridder, Maria, Nakato, Swabra, Molina-León, Helvert Felipe, Elango, Varalakshmi, and Zuber, Patrick L.F.

Published
2018
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31. Operational lessons learned in conducting a multi-country collaboration for vaccine safety signal verification and hypothesis testing: The global vaccine safety multi country collaboration initiative

Author

Kuli-Lito, Georgina, Kostaqi, Entela, Petrela, Elizana, Castellano, Vanesa E., Chiarvetti, Lucia, Falcó, Adriana, Gentile, Angela, Guirau, Karina, Carrega, Maria Eugenia Pérez, Rasjido, Susana, Testino, Sofía, Vizzotti, Carla, Buttery, Jim, Mcminn, Alissa, Quinn, Julie, Avendaño, Marcela, González, Marcela, Lagos, Rosanna, Maturana, Marcelo, Muñoz, Fernando, Saldaña, Adiela, Soza, Guillermo, Zhang, Tao, Zhang, Xiyan, Ding, Yunfang, Zhang, Jun, Alvarez-Olmos, Martha I., Sastoque, Luz Amparo, Mezerville, Marcela Hernández-de, Machado, Vicenta, Roverssi, Ileana, Camacho, Angélica Vargas, Luque, Marco Tulio, Mendoza, Liset, Ravi, Mandyam, Manjunath, V.G., Karimi, Abdollah, Ghanaie, Roxana Mansour, Seifi, Kimia, Shirvani, Fariba, Ashrafi, Mahmoud Reza, Parvaneh, Nima, Kochakzadeh, Leily, Mamishi, Sertareh, Kompani, Farzad, Eshaghi, Hamid, Pirmoazen, Vahideh, Aquije Hernández, Renne F., Díaz, Maria Esther Castillo, Mamani, Gladys Turpo, Thoon, Koh Cheng, Oh, Bee Khiam, Yelen, Cutland, Clare, Madhi, Shabir A., Groome, Michelle, Velaphi, Sithembiso, Izu, Alane, Diep, Linh, Hwinya, Cleopas, Pérez-Vilar, Silvia, Díez-Domingo, Javier, Martín-Navarro, Marian, Soriano-García, Esther, Pande, Stephen Legesi, Alaroker, Florence, Amulen, Dorothy, Akareut, Margaret, Areto, Esther, Komo, Richard Samson, Quinto, Ogwang, Giachetto, Gustavo, Speranza, Noelia, Zunino, Carlos, Guillard-Maure, Christine, Elango, Varalakshmi, Black, Steven, Perez-Vilar, Silvia, Castro, Jose Luis, Bravo-Alcántara, Pamela, Molina-León, Helvert Felipe, Weibel, Daniel, Sturkenboom, Miriam, and Zuber, Patrick L.F.

Published
2018
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33. Low influenza vaccine effectiveness and the effect of previous vaccination in preventing admission with A(H1N1)pdm09 or B/Victoria-Lineage in patients 60 years old or older during the 2015/2016 influenza season

Author

Puig-Barberà, Joan, Guglieri-López, Beatriz, Tortajada-Girbés, Miguel, López-Labrador, F. Xavier, Carballido-Fernández, Mario, Mollar-Maseres, Joan, Schwarz-Chavarri, Germán, Baselga-Moreno, Víctor, Mira-Iglesias, Ainara, and Díez-Domingo, Javier

Published
2017
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34. Safety and immunogenicity of a ChAd155-vectored respiratory syncytial virus vaccine in infants 6–7 months of age: a phase 1/2 randomized trial

Author

Sáez-Llorens, Xavier, primary, Norero, Ximena, additional, Mussi-Pinhata, Marisa Márcia, additional, Luciani, Kathia, additional, Salamanca de la Cueva, Ignacio, additional, Díez-Domingo, Javier, additional, Lopez-Medina, Eduardo, additional, Epalza, Cristina, additional, Brzostek, Jerzy, additional, Szymański, Henryk, additional, Boucher, François D, additional, Cetin, Benhur S, additional, De Leon, Tirza, additional, Cagri Dinleyici, Ener, additional, Marín Gabriel, Miguel Ángel, additional, Ince, Tolga, additional, Macias-Parra, Mercedes, additional, Langley, Joanne M, additional, Martinón-Torres, Federico, additional, Rämet, Mika, additional, Kuchar, Ernest, additional, Pinto, Jorge, additional, Puthanakit, Thanyawee, additional, Baquero-Artigao, Fernando, additional, Castelli Gattinara, Guido, additional, Merino Arribas, Jose Manuel, additional, Ramos Amador, Jose Tomas, additional, Szenborn, Leszek, additional, Tapiero, Bruce, additional, Anderson, Evan J, additional, Campbell, James D, additional, Faust, Saul N, additional, Nikic, Vanja, additional, Zhou, Yingjun, additional, Pu, Wenji, additional, Friel, Damien, additional, Dieussaert, Ilse, additional, Gonzalez Lopez, Antonio, additional, McPhee, Roderick, additional, Stoszek, Sonia K, additional, and Vanhoutte, Nicolas, additional

Published
2023
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37. Antibiotic Use in Children – A Cross-National Analysis of 6 Countries

Author

Youngster, Ilan, Avorn, Jerry, Belleudi, Valeria, Cantarutti, Anna, Díez-Domingo, Javier, Kirchmayer, Ursula, Park, Byung-Joo, Peiró, Salvador, Sanfélix-Gimeno, Gabriel, Schröder, Helmut, Schüssel, Katrin, Shin, Ju-Young, Shin, Sun Mi, Simonsen, Gunnar Skov, Blix, Hege Salvesen, Tong, Angela, Trifirò, Gianluca, Ziv-Baran, Tomer, and Kim, Seoyoung C.

Published
2017
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38. Persistence of bactericidal antibodies following booster vaccination with 4CMenB at 12, 18 or 24 months and immunogenicity of a fifth dose administered at 4 years of age-a phase 3 extension to a randomised controlled trial

Author

Iro, Mildred A., Snape, Matthew D., Voysey, Merryn, Jawad, Sena, Finn, Adam, Heath, Paul T., Bona, Gianni, Esposito, Susanna, Diez-Domingo, Javier, Prymula, Roman, Odueyungbo, Adefowope, Toneatto, Daniela, Dull, Peter, and Pollard, Andrew J.

Published
2017
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40. Safety and Immunogenicity of a ChAd155-Vectored Respiratory Syncytial Virus Vaccine in Infants 6–7 Months of age: A Phase 1/2 Randomized Trial.

Author

Sáez-Llorens, Xavier, Norero, Ximena, Mussi-Pinhata, Marisa Márcia, Luciani, Kathia, Cueva, Ignacio Salamanca de la, Díez-Domingo, Javier, Lopez-Medina, Eduardo, Epalza, Cristina, Brzostek, Jerzy, Szymański, Henryk, Boucher, François D, Cetin, Benhur S, Leon, Tirza De, Dinleyici, Ener Cagri, Gabriel, Miguel Ángel Marín, Ince, Tolga, Macias-Parra, Mercedes, Langley, Joanne M, Martinón-Torres, Federico, and Rämet, Mika

Subjects
RESPIRATORY syncytial virus, VIRAL vaccines, IMMUNE response, RESPIRATORY syncytial virus infections, INFANTS, HUMAN metapneumovirus infection, NEUTRALIZATION tests
Abstract

Background Respiratory syncytial virus (RSV) is a common cause of lower respiratory tract infections in infants. This phase 1/2, observer-blind, randomized, controlled study assessed the safety and immunogenicity of an investigational chimpanzee-derived adenoviral vector RSV vaccine (ChAd155-RSV, expressing RSV F, N, and M2-1) in infants. Methods Healthy 6- to 7-month-olds were 1:1:1-randomized to receive 1 low ChAd155-RSV dose (1.5 × 1010 viral particles) followed by placebo (RSV_1D); 2 high ChAd155-RSV doses (5 × 1010 viral particles) (RSV_2D); or active comparator vaccines/placebo (comparator) on days 1 and 31. Follow-up lasted approximately 2 years. Results Two hundred one infants were vaccinated (RSV_1D: 65; RSV_2D: 71; comparator: 65); 159 were RSV-seronaive at baseline. Most solicited and unsolicited adverse events after ChAd155-RSV occurred at similar or lower rates than after active comparators. In infants who developed RSV infection, there was no evidence of vaccine-associated enhanced respiratory disease (VAERD). RSV-A neutralizing titers and RSV F-binding antibody concentrations were higher post–ChAd155-RSV than postcomparator at days 31, 61, and end of RSV season 1 (mean follow-up, 7 months). High-dose ChAd155-RSV induced stronger responses than low-dose, with further increases post–dose 2. Conclusions ChAd155-RSV administered to 6- to 7-month-olds had a reactogenicity/safety profile like other childhood vaccines, showed no evidence of VAERD, and induced a humoral immune response. Clinical Trials Registration.  NCT03636906. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Anamnestic Immune Response and Safety of an Inactivated Quadrivalent Influenza Vaccine in Primed Versus Vaccine-Naïve Children

Author

Claeys, Carine, Chandrasekaran, Vijayalakshmi, García-Sicilia, José, Prymula, Roman, Díez-Domingo, Javier, Brzostek, Jerzy, Marès-Bermúdez, Josep, Martinón-Torres, Federico, Pollard, Andrew J., Růžková, Renata, Carmona Martinez, Alfonso, Ulied, Angels, Miranda Valdivieso, Mariano, Faust, Saul N., Snape, Matthew D., Friel, Damien, Ollinger, Thierry, Soni, Jyoti, Schuind, Anne, Li, Ping, Innis, Bruce L., and Jain, Varsha K.

Published
2019
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44. Influenza epidemiology and influenza vaccine effectiveness during the 2016–2017 season in the Global Influenza Hospital Surveillance Network (GIHSN)

Author

Baselga-Moreno, Víctor, Trushakova, Svetlana, McNeil, Shelly, Sominina, Anna, Nunes, Marta C., Draganescu, Anca, Unal, Serhat, Koul, Parvaiz, Kyncl, Jan, Zhang, Tao, Kuatbayeva, Ainagul, Ben-Salah, Afif, Burtseva, Elena, Puig-Barberà, Joan, Díez-Domingo, Javier, and for the Global Influenza Hospital Surveillance Network (GIHSN)

Published
2019
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46. Safety and Immunogenicity of a ChAd155-Vectored Respiratory Syncytial Virus (RSV) Vaccine in Healthy RSV-Seropositive Children 12–23 Months of Age

Author

Díez-Domingo, Javier, primary, Sáez-Llorens, Xavier, additional, Rodriguez-Weber, Miguel A, additional, Epalza, Cristina, additional, Chatterjee, Archana, additional, Chiu, Cheng-Hsun, additional, Lin, Chien-Yu, additional, Berry, Andrea A, additional, Martinón-Torres, Federico, additional, Baquero-Artigao, Fernando, additional, Langley, Joanne M, additional, Ramos Amador, José T, additional, Domachowske, Joseph B, additional, Huang, Li-Min, additional, Chiu, Nan-Chang, additional, Esposito, Susanna, additional, Moris, Philippe, additional, Lien-Anh Nguyen, Thi, additional, Nikic, Vanja, additional, Woo, Wayne, additional, Zhou, Yingjun, additional, Dieussaert, Ilse, additional, Leach, Amanda, additional, Gonzalez Lopez, Antonio, additional, and Vanhoutte, Nicolas, additional

Published
2022
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47. Additional file 1 of Clinical and economic burden of physician-diagnosed influenza in adults during the 2017/2018 epidemic season in Spain

Author

Gil-de-Miguel, Ángel, Martinón-Torres, Federico, Díez-Domingo, Javier, de Lejarazu Leonardo, Raúl Ortiz, Pumarola, Tomàs, Carmo, Mafalda, Drago, Georgina, López-Belmonte, Juan Luis, Bricout, Hélène, de Courville, Caroline, and Margüello, Esther Redondo

Abstract

Additional file 1: Table S1. Diagnostic codes used to identify comorbidities for influenza. Table S2. Unit costs considered for each healthcare visit. (a) eSalud original reference: Consejería de Sanidad y Políticas Sociales (2020). Resolución de 6 de febrero de 2020. Diario Oficial de Extremadura, número 28, 11 de febrero de 2020 [29]. (b) Mean cost computed, using the cost for visit in regular working period of the center and outside of that period. eSalud original reference: Consejería de Salud (2018). Orden de 8 de mayo de 2018. Boletín Oficial de la Junta de Andalucía núm. 92, 15 de mayo de 2018 [29].Original costs were updated to 2020 costs using the yearly change in the consumer price index published by the National Statistics Institute of Spain [43]. (c) Mean cost computed, using the cost for first outpatient visit (consulta externa) from two eSalud original references: 1. Consejería de Sanidad y Políticas Sociales (2020). Resolución de 6 de febrero de 2020. Diario Oficial de Extremadura, número 28, 11 de febrero de 2020; 2. Osakidetza-Servicio Vasco de Salud (2020). Acuerdo del Consejo de Administración de 19 de diciembre de2019. Boletín Oficial del País Vasco, nº 21, 31 de enero de 2020 [29]. Mean cost computed, using the cost for subsequent outpatient visits (consulta externa) from two eSalud original references: 1. Consejeríade Sanidad y Políticas Sociales (2020). Resolución de 6 de febrero de 2020. Diario Oficial de Extremadura, número 28, 11 de febrero de 2020; 2. Osakidetza-Servicio Vasco de Salud (2020). Acuerdo del Consejo de Administración de 19 de diciembre de 2019. Boletín Oficial del País Vasco, nº 21, 31 de enero de 2020 [29]. (d) eSalud original reference: Osakidetza-Servicio Vasco de Salud (2020). Acuerdo del Consejo de Administración de 19 de diciembre de 2019. Boletín Oficial del PaísVasco, nº 21, 31 de enero de 2020 [29].Table S3. Mean number of visits to each healthcare setting per influenza case visiting the healthcare setting at least once during their episode and mean length-of-stay for those hospitalized, stratified by age groups and by presence of comorbidities, 2017/2018 season. ED – Emergency Department; HO – Hospital (Inpatient);LOS – Length-of-stay; OP – Outpatient (specialized care); PC – Primary Care. *Each case (patient) may then visit each service more than once, even in the same day (e.g. visit to general practitioner and visit to nurse in the same primary care centre). Table S4. Mean healthcare costs of visits to each healthcare setting per influenza case who visited each healthcare setting, stratified by age groups and presence of comorbidities (€ per case), 2017/2018 season. ED – Emergency Department; HO – Hospital (Inpatient);OP – Outpatient (specialized care); PC – Primary Care; PM – Prescription Medicines. Table S5. Mean cost of retail prescription medicines per influenza case with at least a prescription, by type of prescription medicine;stratified by age groups, 2017/2018 season. COPD - Chronic obstructive pulmonary disease; PM – Prescription Medicines. Table S6. Number of influenza cases visiting each healthcare setting during their influenza episode, stratified by age groups and by presence of comorbidities, 2017/2018 season. ED –Emergency Department; HO – Hospital (Inpatient); OP – Outpatient (specialized care); PC – Primary Care; PM – Prescription Medicines.

Published
2023
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48. Increased severity of influenza-associated hospitalizations in resource-limited settings: Results from the Global Influenza Hospital Surveillance Network (GIHSN)

Author

Cohen, Lily E, primary, Hansen, Chelsea, additional, Andrew, Melissa K, additional, McNeil, Shelly A, additional, Vanhems, Philippe, additional, Kyncl, Jan, additional, Díez Domingo, Javier, additional, Zhang, Tao, additional, Dbaibo, Ghassan, additional, Laguna-Torres, Victor Alberto, additional, Draganescu, Anca, additional, Baumeister, Elsa, additional, Gomez, Doris, additional, Raboni, Sonia M, additional, Giamberardino, Heloisa I G, additional, Nunes, Marta C, additional, Burtseva, Elena, additional, Sominina, Anna, additional, Medić, Snežana, additional, Coulibaly, Daouda, additional, Salah, Afif Ben, additional, Otieno, Nancy A, additional, Koul, Parvaiz A, additional, Unal, Serhat, additional, Tanriover, Mine Durusu, additional, Mazur, Marie, additional, Bresee, Joseph, additional, Viboud, Cecile, additional, and Chaves, Sandra S, additional

Published
2022
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