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1. Repeated pancreatic resection for pancreatic metastases from renal cell Carcinoma: A Spanish multicenter study (PANMEKID)

Author

Rojas-Holguín, Adela, Fondevila-Campo, Constantino, Sanjuanbenito, Alfonso, Fabregat-Prous, Joan, Secanella-Medayo, Luís, Rotellar-Sastre, Fernando, Pardo-Sánchez, Fernando, Prieto-Calvo, Mikel, Marín-Ortega, Héctor, Sánchez-Cabús, Santiago, Diez-Valladares, Luis, Alonso-Casado, Óscar, González-Serrano, Carmen, Rodríguez-Sanjuan, Juan Carlos, García-Plaza, Gabriel, Jaén-Torrejimeno, Isabel, Suárez-Muñoz, Miguel Ángel, Becerra-Massare, Antonio, Rio, Paula Senra-del, Pando, Elizabeth, López-Andújar, Rafael, Muñoz-Forner, Elena, Rodriguez-López, Mario, Pereira, Fernando, Serrablo-Requejo, Alejandro, Turrión, Víctor Sánchez, Garrido, Manuel Jiménez, Burdío, Fernando, Martín-Pérez, Elena, Estevan-Estevan, Rafael, López-Guerra, Diego, Castell-Gómez, José, Salinas-Gómez, Javier, López-Baena, José Ángel, López-Ben, Santiago, Solar-García, Lorena, Pérez-Alonso, Alejandro J., Martínez-Insfran, Luis Alberto, Blas, Juan Luis, Cornejo, Marian, Gutierrez-Calvo, Alberto, Pozo, Carlos Domingo-del, Ochando-Cerdan, Federico, Muñoz-Bellvís, Luis, Rebollar-Saenz, José, Sánchez, Belinda, Jover, José María, Gómez-Bravo, Miguel Ángel, Ramia, José M., and Blanco-Fernández, Gerardo

Published
2024
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2. Preoperative hepatic artery embolization before distal pancreatectomy plus celiac axis resection does not improve surgical results: A Spanish multicentre study

Author

Ramia, Jose M., de Vicente, Emilio, Pardo, Fernando, Sabater, Luis, Lopez-Ben, Santiago, Quijano M, Yolanda, Villegas, Trinidad, Blanco-Fernandez, Gerardo, Diez-Valladares, Luis, Lopez-Rojo, Irene, Martin-Perez, Elena, Pereira, Fernando, Gonzalez, Antonio J., Herrera, Javier, García-Domingo, M.I., and Serradilla-Martín, Mario

Published
2021
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3. POLQ immunostaining behaves as a prognostic factor for pancreatic carcinoma.

Author

Puerto-Nevado, Laura del, Fernández-Aceñero, María J., Cebrián, Arancha, Fatych, Yuliia, Díez-Valladares, Luis I., Pérez-Aguirre, Elia, de la Serna, Sofía, García-Botella, Alejandra, Martínez-Useros, Javier, García-Foncillas, Jesús, and Mateos-Gómez, Pedro A.

Subjects
PROGRESSION-free survival, CANCER prognosis, OVERALL survival, GENE expression profiling, DNA polymerases
Abstract

Background: DNA polymerase theta (POLQ) is a translesion synthesis polymerase essential for the repair of double strand breaks by the error-prone TMEJ (Theta Mediated End Joining) pathway. Although POLQ participates in maintaining genome stability, several studies have shown that its overexpression correlates with cancer progression and poor prognosis. Due to the fact that its role as a biomarker in pancreatic cancer remains unexplored, we aimed to study the usefulness of POLQ H-score as a prognostic factor in a pancreatic cancer patient cohort. Methods: We evaluated POLQ gene expression using a web-based tool to deliver gene expression profiling and interactive analyses based on TCGA and GTEx (GEPIA) and we examined the POLQ immunostaining in 152 biliopancreatic cancer surgical specimens using tissue microarrays. Association with survival was evaluated by Kaplan Meier curves and uni-multivariate Cox regression. Results: GEPIA analysis showed statistical differences according to POLQ mRNA levels in Disease Free Survival (DFS) (log rank 0.023, HR 2.8, p=0.029) and Overall Survival (OS) (log rank 0.011, HR 3.1, p=0.016). For immunohistochemistry (IHC) evaluation, POLQ H-score was calculated, and showed statistical differences for OS in Kaplan Meier curves (log rank 0.001) and uni-multivariate analysis (HR 2.27; 95% CI 1.24-4.15, p=0.008). Conclusions: Our results indicate that POLQ is an independent prognostic factor in pancreatic cancer when analyzed by immunostaining, which is in agreement with the results shown by the POLQ gene expression analysis (GEPIA). [ABSTRACT FROM AUTHOR]

Published
2024
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5. Multicentric Study on Total Pancreatectomies

Author

Fabregat Prous, Joan, Secanella, Lluis, Larrea, Javier, Olea, Sanchez Bueno, Francisco, Botello Martinez, Francisco, Briceño, Javier, Miyar-de León, Alberto, Serradilla, Mario, Serrablo, Alejandro, Ferrer Fabrega, Joana, Sanchez Cabús, S., Angel Gómez Bravo, Miguel, Padillo, Javier, Blanco, Laia, Balcells, J., Cugat, Esteban, García Domingo, Maribel, Muñoz Bellvis, Luis, Dolores Perez Diaz, Maria, Santoyo Santoyo, Julio, Sanchez, Belinda, Villegas, Trinidad, Pacho, Silvino, Díez Valladares, Luis, Rebollar, Jose, Ángel Suárez Muñoz, Miguel, Domínguez, Elías, Martín Perez, Elena, Falgueras, Laia, Poves, Ignasi, Artigas, Vicenç, Sabater, Luis, Garcia Gil, Agustin, Ignacio Miota de Llama, Jose, Manzanet, Gerardo, Carlos Pino, Jose, Carlos Rodríguez Sanjuán, Juan, Lluis, F., Ausania, Fabio, Alkorta Zuloaga, Maialen, Escartín, Jorge, Salas, Manel, Domingo, Carlos, Artigues Sánchez de Rojas, Enrique, Antonio Barreras Mateos, José, María Fernández Cebrián, José, Pérez Cabrera, Beatriz, Padilla Valverde, D., Sanjuanbenito, Alfonso, Iturburu Belmonte, Ignacio, Bejarano, Natalia, García Borobia, F., Toral Guinea, Pablo, Lopez Marcano, Aylhin, Asencio Arana, Francisco, Varo, Evaristo, Esteban, Rafael, Blas, Juan L., Jover Navalón, José M., Fernández Martínez, Cristina, Daban Collado, Enrique, Calvo Duran, Antonio, Vicens, J.C., Romero, J., Badía, J.M., Sánchez, Raquel, de Miguel Ibáñez, Ricardo, Pardoc, Fernando, Francos von Hunefeld, Carlos, Pereira, Fernando, Garcia Molina, Francisco, Rodríguez Prieto, Ignacio, Alonso Poza, Alfredo, Gilsanz, Carlos, Miguel Martínez Albert, Jose, Angel Morcillo, Miguel, Martínez Cortijo, Sagrario, Martín Fernández, José, Baquedano, Jesús, Castell, José, Aguiló, Javier, Carlos Bernal, Juan, Ramia, Jose M., Martin-Perez, Elena, Fabregat-Prous, Joan, Larrea y Olea, Javier, Sanchez-Bueno, Francisco, Botello-Martinez, Francisco, and Moya-Herraiz, Angel

Published
2019
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6. Estudio multicéntrico nacional sobre pancreatectomías totales

Author

Fabregat Prous, Joan, Secanella, Lluis, Larrea y Olea, Javier, Sanchez Bueno, Francisco, Botello Martinez, Francisco, Briceño, Javier, Miyar-de León, Alberto, Serradilla, Mario, Serrablo, Alejandro, Ferrer Fabrega, Joana, Sanchez Cabús, S., Angel Gómez Bravo, Miguel, Padillo, Javier, Blanco, Laia, Balcells, J., Cugat, Esteban, García Domingo, Maribel, Muñoz Bellvis, Luis, Dolores Perez Diaz, Maria, Santoyo Santoyo, Julio, Sanchez, Belinda, Villegas, Trinidad, Pacho, Silvino, Díez Valladares, Luis, Rebollar, Jose, Ángel Suárez Muñoz, Miguel, Domínguez, Elías, Martín Perez, Elena, Falgueras, Laia, Poves, Ignasi, Artigas, Vicenç, Sabater, Luis, Garcia Gil, Agustin, Ignacio Miota de Llama, Jose, Manzanet, Gerardo, Carlos Pino, Jose, Carlos Rodríguez Sanjuán, Juan, Lluis, F., Ausania, Fabio, Alkorta Zuloaga, Maialen, Escartín, Jorge, Salas, Manel, Domingo, Carlos, Artigues Sánchez de Rojas, Enrique, Antonio Barreras Mateos, José, María Fernández Cebrián, José, Pérez Cabrera, Beatriz, Padilla Valverde, D., Sanjuanbenito, Alfonso, Iturburu Belmonte, Ignacio, Bejarano, Natalia, García Borobia, F., Toral Guinea, Pablo, Lopez Marcano, Aylhin, Asencio Arana, Francisco, Varo, Evaristo, Esteban, Rafael, Blas, Juan Laaa, Jover Navalón, José M., Fernández Martínez, Cristina, Daban Collado, Enrique, Calvo Duran, Antonio, Vicens, J.C., Romero, J., Badía, J.M., Sánchez, Raquel, de Miguel Ibáñez, Ricardo, Pardoc, Fernando, Francos von Hunefeld, Carlos, Pereira, Fernando, Garcia Molina, Francisco, Rodríguez Prieto, Ignacio, Alonso Poza, Alfredo, Gilsanz, Carlos, Miguel Martínez Albert, Jose, Angel Morcillo, Miguel, Martínez Cortijo, Sagrario, Martín Fernández, José, Baquedano, Jesús, Castell, José, Aguiló, Javier, Carlos Bernal, Juan, Ramia, Jose M., Martin-Perez, Elena, Fabregat-Prous, Joan, Sanchez-Bueno, Francisco, Botello-Martinez, Francisco, and Moya-Herraiz, Angel

Published
2019
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9. Multicentre Study on Hepatic Adenomas

Author

Ramia, José Manuel, Bernardo, Carmen, Valdivieso, Andrés, Dopazo, Cristina, Jover, José María, Albiol, M. Teresa, Pardo, Fernando, Fernandez Aguilar, José Luis, Gutierrez Calvo, Alberto, Serrablo, Alejandro, Diez Valladares, Luis, Pereira, Fernando, Sabater, Luis, Muffak, Karim, and Figueras, Joan

Published
2014
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10. Estudio multicéntrico sobre adenomas hepáticos

Author

Ramia, José Manuel, Bernardo, Carmen, Valdivieso, Andrés, Dopazo, Cristina, Jover, José María, Albiol, M. Teresa, Pardo, Fernando, Fernandez Aguilar, José Luis, Gutierrez Calvo, Alberto, Serrablo, Alejandro, Diez Valladares, Luis, Pereira, Fernando, Sabater, Luis, Muffak, Karim, and Figueras, Joan

Published
2014
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19. Resultados de una encuesta sobre el soporte nutricional perioperatorio en la cirugía pancreática y biliar en España

Author

Loinaz, Carmelo, Ochando, Federico, Vicente, Emilio, Serrablo, Alejandro, López Cillero, Pablo, Gómez, Miguel Ángel, Fabregat Prous, Joan, Varo, Evaristo, Miyar de Leon, Albert, Fondevila, Constantino, Valdivieso, Andrés, Blanco, Gerardo, Sánchez, Belinda, López Andújar, Rafael, Fundora, Yilian, Cugat Andorrà, Esteban, Díez Valladares, Luis, Herrera, Javier, García Gil, Agustín, Morales, Rafael, Pardo, Fernando, Sabater, Luis, Baena, José Ángel, Muñoz Bellvis, Luis, Martín Pérez, Elena, Pérez Saborido, Baltasar, Suárez, Miguel Ángel, Meneu, Juan Carlos, Albiol, Maite, Sanjuanbenito, Alfonso, Ramia, José Miguel, Pereira, Fernando, Paseiro, Gloria, Palomo, Juan Carlos, Leon, Miguel, GENPOCIRP (Grupo Encuesta Nutrición PeriOperatoria en CIRugia Pancreatobiliar), UAM. Departamento de Cirugía, and Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-IP)

Subjects
medicine.medical_specialty, Medicina, Medicine (miscellaneous), Páncreas. Biliar. Cirugía. Nutrición, Nutritional Status, Critical Care and Intensive Care Medicine, Pancreatic head, Biliary surgery, Pancreatic surgery, Pancreatectomy, Surveys and Questionnaires, medicine, Humans, Malalties del pàncrees, Pancreas, Nutrició, Nutrition, Nutrition and Dietetics, Nutritional Support, business.industry, General surgery, Biliary, Guideline, Perioperative, Middle Aged, Biliar, Pancréas diseases, Biliary Tract Surgical Procedures, Páncreas, Solid food, Spain, Nutrición, Surgery, Preoperative fasting, business, Oral feeding
Abstract

Introduction: a survey on peri-operative nutritional support in pancreatic and biliary surgery among Spanish hospitals in 2007 showed that few surgical groups followed the 2006 ESPEN guidelines. Ten years later we sent a questionnaire to check the current situation. Methods: a questionnaire with 21 items sent to 38 centers, related to fasting time before and after surgery, nutritional screening use and type, time and type of peri-operative nutritional support, and number of procedures. Results: thirty-four institutions responded. The median number of pancreatic resections (head/total) was 29.5 (95% CI: 23.0-35; range, 5-68) (total, 1002); of surgeries for biliary malignancies (non-pancreatic), 9.8 (95% CI: 7.3-12.4; range, 2-30); and of main biliary resections for benign conditions, 10.4 (95% CI: 7.6-13.3; range, 2-33). Before surgery, only 41.2% of the sites used nutritional support (< 50% used any nutritional screening procedure). The mean duration of preoperative fasting for solid foods was 9.3 h (range, 6-24 h); it was 6.6 h for liquids (range, 2-12). Following pancreatic surgery, 29.4% tried to use early oral feeding, but 88.2% of the surveyed teams used some nutritional support; 26.5% of respondents used TPN in 100% of cases. Different percentages of TPN and EN were used in the other centers. In malignant biliary surgery, 22.6% used TPN always, and EN in 19.3% of cases. Conclusions: TPN is the commonest nutrition approach after pancreatic head surgery. Only 29.4% of the units used early oral feeding, and 32.3% used EN; 22.6% used TPN regularly after surgery for malignant biliary tumours. The 2006 ESPEN guideline recommendations are not regularly followed 12 years after their publication in our country., Introducción: realizamos una encuesta sobre soporte nutricional perioperatorio en cirugía pancreática y biliar en hospitales españoles en 2007, que mostró que pocos grupos quirúrgicos seguían las guías de ESPEN 2006. Diez años después enviamos un cuestionario para comprobar la situación actual. Métodos: treinta y ocho centros recibieron un cuestionario con 21 preguntas sobre tiempo de ayunas antes y después de la cirugía, cribado nutricional, duración y tipo de soporte nutricional perioperatorio, y número de procedimientos. Resultados: respondieron 34 grupos. La mediana de pancreatectomías (cabeza/total) fue de 29,5 (IC 95 %: 23,0-35; rango, 5-68) (total, 1002), la de cirugías biliares malignas de 9,8 (IC 95 %: 7,3-12,4; rango, 2-30) y la de resecciones biliares por patología benigna de 10,4 (IC 95 %: 7,6-13,3; rango, 2-33). Solo el 41,2 % de los grupos utilizaban soporte nutricional antes de la cirugía (< 50 % habian efectuado un cribado nutricional). El tiempo medio de ayuno preoperatorio para sólidos fue de 9,3 h (rango, 6-24 h), y de 6,6 h para líquidos (rango, 2-12). Tras la pancreatectomía, el 29,4 % habían intentado administrar una dieta oral precoz, pero el 88,2 % de los grupos usaron algún tipo de soporte nutricional y el 26,5 % usaron NP en el 100 % de los casos. Los demás grupos usaron diferentes porcentajes de NP y NE en sus casos. En la cirugía biliar maligna, el 22,6 % utilizaron NP siempre y NE en el 19,3 % de los casos. Conclusiones: la NP es el soporte nutricional más utilizado tras la cirugía de cabeza pancreática. Solo el 29,4 % de las unidades usan nutrición oral precoz y el 32,3 % emplean la NE tras este tipo de cirugía. El 22,6 % de las instituciones usan NP habitualmente tras la cirugía de tumores biliares malignos. Las guías ESPEN 2006 no se siguen de forma habitual en nuestro país tras más de 10 años desde su publicación.

Published
2020

22. Results of a survey on peri-operative nutritional support in pancreatic and biliary surgery in Spain

Author

Loinaz Segurola, Carmelo, primary, Ochando Cerdán, Federico, additional, Vicente López, Emilio, additional, Serrablo Requejo, Alejandro, additional, López Cillero, Pedro, additional, Gómez Bravo, Miguel Ángel, additional, Fabregat Prous, Juan, additional, Varo Pérez, Evaristo, additional, Miyar de León, Albert, additional, Fondevila Campo, Constantino, additional, Valdivieso López, Andrés, additional, Blanco Fernández, Gerardo, additional, Sánchez, Belinda, additional, López Andújar, Rafael, additional, Fundora Suárez, Yilian, additional, Cugat Andorra, Esteban, additional, Díez Valladares, Luis, additional, Herrera Cabezón, Javier, additional, García Gil, Agustín, additional, Morales Soriano, Rafael, additional, Pardo Sánchez, Fernando, additional, Sabater Ortí, Luis, additional, López Baena, José Ángel, additional, Muñoz Bellvís, Luis, additional, Martín Pérez, Elena, additional, Pérez Saborido, Baltasar, additional, Suárez Muñoz, Miguel Ángel, additional, Meneu Día, Juan Carlos, additional, Albiol Quer, Maite, additional, Sanjuanbenito Dehesa, Alfonso, additional, Ramia Ángel, José Ángel, additional, Pereira Pérez, Fernando, additional, Paseiro Crespo, Gloria, additional, Palomo Sánchez, Juan Carlos, additional, and León Sanz, Miguel, additional

Published
2020
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23. Estudio multicéntrico nacional sobre pancreatectomías totales

Author

Ramia, Jose M., primary, Martin-Perez, Elena, additional, Poves, Ignasi, additional, Fabregat-Prous, Joan, additional, Larrea y Olea, Javier, additional, Sanchez-Bueno, Francisco, additional, Botello-Martinez, Francisco, additional, Briceño, Javier, additional, Miyar-de León, Alberto, additional, Serradilla, Mario, additional, Moya-Herraiz, Angel, additional, Fabregat Prous, Joan, additional, Secanella, Lluis, additional, Sanchez Bueno, Francisco, additional, Botello Martinez, Francisco, additional, Serrablo, Alejandro, additional, Ferrer Fabrega, Joana, additional, Sanchez Cabús, S., additional, Angel Gómez Bravo, Miguel, additional, Padillo, Javier, additional, Blanco, Laia, additional, Balcells, J., additional, Cugat, Esteban, additional, García Domingo, Maribel, additional, Muñoz Bellvis, Luis, additional, Dolores Perez Diaz, Maria, additional, Santoyo Santoyo, Julio, additional, Sanchez, Belinda, additional, Villegas, Trinidad, additional, Pacho, Silvino, additional, Díez Valladares, Luis, additional, Rebollar, Jose, additional, Ángel Suárez Muñoz, Miguel, additional, Domínguez, Elías, additional, Martín Perez, Elena, additional, Falgueras, Laia, additional, Artigas, Vicenç, additional, Sabater, Luis, additional, Garcia Gil, Agustin, additional, Ignacio Miota de Llama, Jose, additional, Manzanet, Gerardo, additional, Carlos Pino, Jose, additional, Carlos Rodríguez Sanjuán, Juan, additional, Lluis, F., additional, Ausania, Fabio, additional, Alkorta Zuloaga, Maialen, additional, Escartín, Jorge, additional, Salas, Manel, additional, Domingo, Carlos, additional, Artigues Sánchez de Rojas, Enrique, additional, Antonio Barreras Mateos, José, additional, María Fernández Cebrián, José, additional, Pérez Cabrera, Beatriz, additional, Padilla Valverde, D., additional, Sanjuanbenito, Alfonso, additional, Iturburu Belmonte, Ignacio, additional, Bejarano, Natalia, additional, García Borobia, F., additional, Toral Guinea, Pablo, additional, Lopez Marcano, Aylhin, additional, Asencio Arana, Francisco, additional, Varo, Evaristo, additional, Esteban, Rafael, additional, Blas, Juan Laaa, additional, Jover Navalón, José M., additional, Fernández Martínez, Cristina, additional, Daban Collado, Enrique, additional, Calvo Duran, Antonio, additional, Vicens, J.C., additional, Romero, J., additional, Badía, J.M., additional, Sánchez, Raquel, additional, de Miguel Ibáñez, Ricardo, additional, Pardoc, Fernando, additional, Francos von Hunefeld, Carlos, additional, Pereira, Fernando, additional, Garcia Molina, Francisco, additional, Rodríguez Prieto, Ignacio, additional, Alonso Poza, Alfredo, additional, Gilsanz, Carlos, additional, Miguel Martínez Albert, Jose, additional, Angel Morcillo, Miguel, additional, Martínez Cortijo, Sagrario, additional, Martín Fernández, José, additional, Baquedano, Jesús, additional, Castell, José, additional, Aguiló, Javier, additional, and Carlos Bernal, Juan, additional

Published
2019
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24. Análisis del volumen esplénico como biomarcador de daño hepático en pacientes con metástasis de cáncer colorrectal tratados con quimioterapia

Author

García Botella, Alejandra, Díez Valladares, Luis Ignacio, Torres García, Antonio José, Sáez Carlín, Patricia, García Botella, Alejandra, Díez Valladares, Luis Ignacio, Torres García, Antonio José, and Sáez Carlín, Patricia

Abstract

La enfermedad metastásica hepática de cáncer colorrectal (CCR) es un problema clínico importante. El hígado es el órgano metastásico predominante para los pacientes con CCR y el 30 % de los pacientes van a cursar con enfermedad hepática aislada. Los avances en los tratamientos quimioterápicos han mejorado la supervivencia de estos pacientes y los últimos ensayos clínicos reportan una supervivencia media de 30 meses. A pesar de ello, la resección hepática es el tratamiento más eficaz para prolongarla supervivencia a largo plazo, ofreciendo la posibilidad de curación de la enfermedad hepática aislada en pacientes en estadio IV. Así pues, un tratamiento quirúrgico adecuado en combinación con las nuevas quimioterapias, es la mejor opción que podemos ofrecer a este grupo de pacientes en la actualidad. No obstante, el entusiasmo por la quimioterapia sistémica ha sido templado por estudios que la relacionan con daño hepático de tipo esteatohepatitis y daño sinusoidal,después de tratamientos con irinotecán y oxaliplatino. Además, se ha visto una relación significativa entre el daño hepático y la morbimortalidad postoperatoria..., Colorectal liver metastases (CRLM) is an important clinical problem. The liver is the main metastatic organ for patients with colorectal cancer (CRC) and 30% of patients will only evolve with isolated liver disease. Advances in chemotherapy treatments have improved the survival of these patients and the latest clinical trials report an average survival of 30 months. Despite this, hepatic resection is the most effective treatment in order to prolong long-term survival, offering the possibility of cure in selected patients with stage IV liver disease CRC. Thus, adequate surgical treatment in combination with the new chemotherapies is the best option we can offer to this group of patients nowadays. However, the enthusiasm for systemic chemotherapy has been tempered by studies that relate it to liver damage as steatohepatitis and sinusoidal obstruction, after treatments with irinotecan and oxaliplatin. In addition, a significant relationship has been found between liver damage and postoperative morbidity and mortality. The necessity of reliable studies that can diagnose the liver damage is essential to allow an adequate selection of patients candidates for hepatic resection after chemotherapy. In this sense,some current studies suggest that the monitoring of the spleen volume could be considered a biomarker of liver damage and consequently of the morbidity and mortality associated to the surgery...

Published
2019

28. Análisis del volumen esplénico como biomarcador de daño hepático en pacientes con metástasis de cáncer colorrectal tratados con quimioterapia

Author

Sáez Carlín, Patricia, García Botella, Alejandra, Díez Valladares, Luis Ignacio, Torres García, Antonio José, Sáez Carlín, Patricia, García Botella, Alejandra, Díez Valladares, Luis Ignacio, and Torres García, Antonio José

Abstract

La enfermedad metastásica hepática de cáncer colorrectal (CCR) es un problema clínico importante. El hígado es el órgano metastásico predominante para los pacientes con CCR y el 30 % de los pacientes van a cursar con enfermedad hepática aislada. Los avances en los tratamientos quimioterápicos han mejorado la supervivencia de estos pacientes y los últimos ensayos clínicos reportan una supervivencia media de 30 meses. A pesar de ello, la resección hepática es el tratamiento más eficaz para prolongarla supervivencia a largo plazo, ofreciendo la posibilidad de curación de la enfermedad hepática aislada en pacientes en estadio IV. Así pues, un tratamiento quirúrgico adecuado en combinación con las nuevas quimioterapias, es la mejor opción que podemos ofrecer a este grupo de pacientes en la actualidad. No obstante, el entusiasmo por la quimioterapia sistémica ha sido templado por estudios que la relacionan con daño hepático de tipo esteatohepatitis y daño sinusoidal,después de tratamientos con irinotecán y oxaliplatino. Además, se ha visto una relación significativa entre el daño hepático y la morbimortalidad postoperatoria...

Published
2017

35. Effects of Weight Loss after Bariatric Surgery for Morbid Obesity on Vascular Endothelial Growth Factor-A, Adipocytokines, and Insulin

Author

García de la Torre, Nuria, primary, Rubio, Miguel A., additional, Bordiú, Elena, additional, Cabrerizo, Lucio, additional, Aparicio, Eugenio, additional, Hernández, Carmen, additional, Sánchez-Pernaute, Andrés, additional, Díez-Valladares, Luis, additional, Torres, Antonio J., additional, Puente, Montserrat, additional, and Charro, Aniceto L., additional

Published
2008
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36. POLQ immunostaining behaves as a prognostic factor for pancreatic carcinoma.

Author

Del Puerto-Nevado L, Fernández-Aceñero MJ, Cebrián A, Fatych Y, Díez-Valladares LI, Pérez-Aguirre E, de la Serna S, García-Botella A, Martínez-Useros J, García-Foncillas J, and Mateos-Gómez PA

Abstract

Background: DNA polymerase theta (POLQ) is a translesion synthesis polymerase essential for the repair of double strand breaks by the error-prone TMEJ (Theta Mediated End Joining) pathway. Although POLQ participates in maintaining genome stability, several studies have shown that its overexpression correlates with cancer progression and poor prognosis. Due to the fact that its role as a biomarker in pancreatic cancer remains unexplored, we aimed to study the usefulness of POLQ H-score as a prognostic factor in a pancreatic cancer patient cohort., Methods: We evaluated POLQ gene expression using a web-based tool to deliver gene expression profiling and interactive analyses based on TCGA and GTEx (GEPIA) and we examined the POLQ immunostaining in 152 biliopancreatic cancer surgical specimens using tissue microarrays. Association with survival was evaluated by Kaplan Meier curves and uni-multivariate Cox regression., Results: GEPIA analysis showed statistical differences according to POLQ mRNA levels in Disease Free Survival (DFS) (log rank 0.023, HR 2.8, p= 0.029) and Overall Survival (OS) (log rank 0.011, HR 3.1, p= 0.016). For immunohistochemistry (IHC) evaluation, POLQ H-score was calculated, and showed statistical differences for OS in Kaplan Meier curves (log rank 0.001) and uni-multivariate analysis (HR 2.27; 95% CI 1.24-4.15, p =0.008)., Conclusions: Our results indicate that POLQ is an independent prognostic factor in pancreatic cancer when analyzed by immunostaining, which is in agreement with the results shown by the POLQ gene expression analysis (GEPIA)., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 del Puerto-Nevado, Fernández-Aceñero, Cebrián, Fatych, Díez-Valladares, Pérez-Aguirre, de la Serna, García-Botella, Martínez-Useros, García-Foncillas and Mateos-Gómez.)

Published
2024
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37. Expression of MMP-9 and TIMP-1 as prognostic markers in gastric carcinoma.

Author

de Mingo M, Morán A, Sánchez-Pernaute A, Iniesta P, Díez-Valladares L, Pérez-Aguirre E, de Juan C, García-Aranda C, Díaz-López A, García-Botella A, Martín-Antona E, Benito M, Torres A, and Balibrea JL

Subjects
Adenocarcinoma mortality, Aged, Enzyme-Linked Immunosorbent Assay, Female, Gastric Mucosa metabolism, Humans, Male, Prognosis, Stomach Neoplasms mortality, Survival Analysis, Adenocarcinoma metabolism, Biomarkers, Tumor metabolism, Matrix Metalloproteinase 9 metabolism, Stomach Neoplasms metabolism, Tissue Inhibitor of Metalloproteinase-1 metabolism
Abstract

Background/aims: The aim of the present work is to clarify the role of metalloproteinase-9 and its inhibitor in the evolution of gastric cancer after surgical resection., Methodology: We have studied 44 gastric cancer patients submitted to surgery. There were 13 proximal tumors, 16 located in the middle third and 15 in the distal one. Overall survival was 26% at 6 years. Metalloproteinase-9 and tissue inhibitor of metalloproteinase concentrations were investigated by means of ELISA in frozen samples of tumoral and normal gastric mucosa., Results: Mean concentration of metalloproteinase-9 in tumoral tissue was 42 ng/mg of total protein, and this value was 6.9 times greater than the mean concentration in non-tumoral tissue. Cancer tissue also expressed higher levels of TIMP-1, 7.25 versus 4.39 ng/mg of protein. Higher levels of metalloproteinase expression in tumoral tissue, greater [metalloproteinase in tumor]/[metalloproteinase in non-tumor] ratio and greater [metalloproteinase]/[inhibitor] ratio in tumor cells, were all of them statistically related to a worse prognosis when T1 and T2 tumors were considered., Conclusions: The expression of metalloproteinase-9 or its inhibitor is related to a more aggressive phenotype of gastric cancer.

Published
2007

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