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The early diagnosis and personalised treatment of diseases are facilitated by machine learning. The quality of data has an impact on diagnosis because medical data are usually sparse, imbalanced, and contain irrelevant attributes, resulting in suboptimal diagnosis. To address the impacts of data challenges, improve resource allocation, and achieve better health outcomes, a novel visual learning approach is proposed. This study contributes to the visual learning approach by determining whether less or more synthetic data are required to improve the quality of a dataset, such as the number of observations and features, according to the intended personalised treatment and early diagnosis. In addition, numerous visualisation experiments are conducted, including using statistical characteristics, cumulative sums, histograms, correlation matrix, root mean square error, and principal component analysis in order to visualise both original and synthetic data to address the data challenges. Real medical datasets for cancer, heart disease, diabetes, cryotherapy and immunotherapy are selected as case studies. As a benchmark and point of classification comparison in terms of such as accuracy, sensitivity, and specificity, several models are implemented such as k-Nearest Neighbours and Random Forest. To simulate algorithm implementation and data, Generative Adversarial Network is used to create and manipulate synthetic data, whilst, Random Forest is implemented to classify the data. An amendable and adaptable system is constructed by combining Generative Adversarial Network and Random Forest models. The system model presents working steps, overview and flowchart. Experiments reveal that the majority of data-enhancement scenarios allow for the application of visual learning in the first stage of data analysis as a novel approach. To achieve meaningful adaptable synergy between appropriate quality data and optimal classification performance while maintaining statistical characteristics, visual learning provides researchers and practitioners with practical human-in-the-loop machine learning visualisation tools. Prior to implementing algorithms, the visual learning approach can be used to actualise early, and personalised diagnosis. For the immunotherapy data, the Random Forest performed best with precision, recall, f-measure, accuracy, sensitivity, and specificity of 81%, 82%, 81%, 88%, 95%, and 60%, as opposed to 91%, 96%, 93%, 93%, 96%, and 73% for synthetic data, respectively. Future studies might examine the optimal strategies to balance the quantity and quality of medical data., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)

Purpose: To evaluate the outcomes of arthroscopic transtendon repair of partial articular-sided supraspinatus tendon avulsion (PASTA) in a large study group., Methods: A retrospective review of prospectively collected data was conducted. One hundred and eighteen patients with PASTA lesion (grade A2-A3) who underwent arthroscopic transtendon repair were identified, of which 110 were eligible for the study. Ten patients were lost at final follow-up leaving a study group of 100 patients (52 male, 48 female). The average follow-up was 37 months (minimum 24 months, range 24-50, median 40). Mean age at the time of surgery was 50.4 (range 17-71, median 45). Patients were assessed before surgery and at 24-month follow-up, using the Simple Shoulder Test (SST), UCLA shoulder rating scale and the visual analogue scale (VAS). ROM was measured bilaterally and was evaluated before surgery, at 3-, 6- and 24-month follow-up. The satisfaction rate was calculated. Data were analysed using a paired Student's t test with 95 % confidence interval (significance p < 0.05)., Results: Significant improvement in UCLA, SST and VAS score was observed. Fifty-four cases were rated excellent, 42 good, 2 fair, 2 poor according to the UCLA score. No significant differences in ROM were noted compared to the contra-lateral side (p < 0.001) at the 24-month follow-up. Eighteen patients presented with a stiff shoulder at the 3-month follow-up, but they recovered full ROM by the 6-month follow-up evaluation., Conclusions: The arthroscopic transtendon repair of partial articular-sided rotator cuff tears is an effective procedure that leads to significant improvement in pain and shoulder function, with high patients' satisfaction rate, while the complication rate is low. This study demonstrated the effectiveness and safety of this technique in a large homogeneous study group., Level of Evidence: IV.

The sensitivity of total serum bile acid concentration as an index of hepatic damage has long been recognised. In addition serum bile acid measurement is significantly more specific than conventional hepatic function tests. However the concentration might be affected by factors other than hepatic dysfunction. Several authors have reported variations in the synthesis of serum bile acids in dyslipidaemic patients. This might potentially reduce the value of concentration measurement in the diagnosis of hepatic diseases especially considering the relative prevalence of hyperlipidaemia. The present article reports on radioimmunological serum bile acid measurement before and after meals in 10 patients with dyslipidaemia and in 22 controls. No difference was revealed between the two groups. Therefore dyslipidaemia appears not to affect the specificity of the test nor does it invalidate the use of radioimmunological measurement of total serum bile acids in the study of hepatic function.

C-reactive protein and rheumatoid factor assays are relevant laboratory parameters, among the most used in the clinical practice, being very useful in diagnosing and "monitoring" rheumatic diseases. A quantitative test to detect these two serum proteins is an important, more specific, new tool for clinical medicine. In our study we evaluated two new laser nephelometric assays, both quantitative, based on the agglutination of polystyrene latex particles, able to show serum concentration of CRP and RF. With a similar technique we tested the presence of circulating immune complexes. We performed our tests in a group of patients with rheumatoid arthritis, other autoimmune diseases, and healthy blood bank donors assaying simultaneously, whenever possible, the "classic" Rose-Waaler and RA tests. We found both methods easy to perform, well correlating with the semi-quantitative techniques and highly reproducible.

The authors studied 22 patients with severe dysphagia, and follow-up studies showed the appearance of some esophageal peristalsis for the first time in three of these patients after Heller myotomy. Comparison of pre- and postoperative clinical, radiological, and manometric data of these three subjects and the data of the other 19 patients showed no statistically significant differences between the two groups of patients either before or after cardiomyotomy except for the unusual appearance of esophageal peristalsis after surgery. According to these results it is not possible to predict which patients will develop peristalsis after cardiomyotomy. The different motor pattern observed after surgery might suggest the existence of a different pathogenesis underlying the esophageal motor disorders in these two groups of patients.

The behaviour of the serum levels of thyroxine (T4), 3,5,3' tri-iodothyronine (T3), TSH and of the free binding sites of the thyroid hormones binding globulins in 23 patients affected by hepatic cirrhosis, is described in function of the severity of the disease. The values obtained have been statistically compared to those of a group of 14 healthy subjects. A decrease of the serum levels of T3 directly related to the severity of the disease has been remarked in the cirrhotic patients, while no significant differences in the serum levels of T4 and TSH and in the number of free binding sites on the thyroid hormones binding globulins have been noted between the two groups.