102 results on '"D, Kohen"'
Search Results
2. Intentional injury hospitalizations in geographical areas with a high percentage of Aboriginal-identity residents, 2004/2005 to 2009/2010
- Author
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L N, Oliver, P, Finès, E, Bougie, and D, Kohen
- Subjects
Adult ,Male ,Canada ,Drowning ,Adolescent ,Poisoning ,Infant, Newborn ,Infant ,Middle Aged ,Violence ,Hospitalization ,Young Adult ,Sex Factors ,Inuit ,Child, Preschool ,Indians, North American ,Humans ,Female ,Body Piercing ,Child ,Self-Injurious Behavior ,Demography - Abstract
This study describes rates of self-inflicted and assault-related injury hospitalizations in areas with a relatively high percentage of residents identifying as First Nations, Métis and Inuit, by injury cause, age group and sex.All separation records from acute in-patient hospitals for Canadian provinces and territories excluding Quebec were obtained from the Discharge Abstract Database. Dissemination areas with more than 33% of residents reporting an Aboriginal identity in the 2006 Census were categorized as high-percentage Aboriginal-identity areas.Overall, in high-percentage Aboriginal-identity areas, age-standardized hospitalization rates (ASHRs) for self-inflicted injuries were higher among females, while ASHRs for assault-related injuries were higher among males. Residents of high-percentage Aboriginal-identity areas were at least three times more likely to be hospitalized due to a self-inflicted injury and at least five times more likely to be hospitalized due to an assault-related injury compared with those living in low-percentage Aboriginal-identity areas.Future research should examine co-morbidities, socio-economic conditions and individual risk behaviours as factors associated with intentional injury hospitalizations.Hospitalisations pour blessures intentionnelles dans les régions à fort pourcentage de résidents d’identité autochtone, 2004-2005 à 2009-2010.Cette étude décrit les taux d’hospitalisation pour blessures auto-infligées et pour blessures par agression dans les régions à pourcentage relativement élevé de résidents s’identifiant comme membres des Premières nations, Métis ou Inuits, par cause de blessure, par tranche d’âge et par sexe.Tous les dossiers de sortie des hôpitaux de soins de courte durée des provinces et territoires du Canada hors Québec ont été tirés de la Base de données sur les congés des patients. Les aires de diffusion où plus de 33 % des résidents ont déclaré appartenir à un groupe autochtone au recensement de 2006 ont été classées comme « régions à fort pourcentage d’Autochtones ».Dans l’ensemble, dans les régions à fort pourcentage d’Autochtones, les taux d’hospitalisation normalisés selon l’âge (THNA) pour blessures auto-infligées étaient plus élevés chez les femmes, tandis que les THNA pour blessures par agression étaient plus élevés chez les hommes. Comparativement aux résidents des régions à faible pourcentage d’Autochtones, les résidents des régions à fort pourcentage d’Autochtones étaient au moins trois fois plus susceptibles d’avoir été hospitalisés pour blessures autoinfligées et au moins cinq fois plus susceptibles d’avoir été hospitalisés pour blessures par agression.Les recherches à venir devraient analyser les comorbidités et les conditions socioéconomiques ainsi que les comportements à risque individuels comme facteurs associés à l’hospitalisation pour blessures auto-infligées.
- Published
- 2014
3. DISABILITY ASSESSMENT IN A POPULATION WITH LEARNING DISABILITIES IN THE COMMUNITY: A FOLLOW-UP STUDY
- Author
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G. Mathew, N. P. Sebaratnam, D. Kohen, and L. Fernando
- Subjects
Gerontology ,education.field_of_study ,business.industry ,Population ,Follow up studies ,Mental handicap ,Disability assessment ,Psychiatry and Mental health ,Long stay ,Learning disability ,Developmental and Educational Psychology ,Medicine ,Medical model of disability ,medicine.symptom ,business ,education - Abstract
With the philosophy of community care and implementation of resettlement programmes the large mental handicap hospitals have discharged the majority . . of their patients into thelocal communities. ~ e f i Barnes Hospital in St. Albans, Herts. is one of these hospitals where active resettlement programmes are going on at present, and some of its long stay patients have been in the community for some time now.
- Published
- 1997
4. Neuroleptic malignant syndrome
- Author
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M. Bristow and D. Kohen
- Subjects
Neuroleptic Drugs ,Pediatrics ,medicine.medical_specialty ,Idiosyncrasy ,business.industry ,Catatonia ,medicine.disease ,030227 psychiatry ,Neuroleptic malignant syndrome ,03 medical and health sciences ,Psychiatry and Mental health ,0302 clinical medicine ,Dopamine ,medicine ,030212 general & internal medicine ,business ,medicine.drug - Abstract
Although a rare form of ‘lethal’ catatonia, involving high temperature and rigidity, was first described long before the advent of neuroleptic drugs, Delay's description of a syndrome malin in 1960 is usually regarded as the first recognition of this syndrome. Over the next 20 years the number of case reports grew and the appearance of reviews such as Caroff's in 1980 marked the birth of the neuroleptic malignant syndrome (NMS). Reports of its incidence give variation rates of up to fiftyfold, possibly due to differences in diagnostic criteria, and mortality reports are similarly variable. Although it is debatable whether it is a rare, severe idiosyncrasy or one of many neuromuscular side-effects of dopamine antagonists (Levinson & Simpson, 1986), most clinicians nowadays regard it as a serious but recognisable risk of neuroleptic treatment which merits further attention.
- Published
- 1996
5. Eltoprazine in aggressive mentally handicapped patients
- Author
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P. de Koning, M. Mak, M. H. de Vries, L. F. Allsopp, R. B. Stevens, R. Verbruggen, R. Van den Borre, P. van Peteghem, D. Kohen, M. Arumainayagam, R. V. Browne, S. P. Tyrer, S. G. Read, A. Jones, B. I. Sacks, R. Tokola, M. Kaski, M. Järvelinʼs, U. Hagert, C. Claden, P. Doubliez, M. Pallegoix, and C. Gaussares
- Subjects
medicine.medical_specialty ,Aggression ,business.industry ,Therapeutic effect ,Eltoprazine ,Placebo ,law.invention ,Clinical trial ,Double blind ,Psychiatry and Mental health ,Randomized controlled trial ,law ,medicine ,Physical therapy ,Pharmacology (medical) ,Personality Assessment Inventory ,medicine.symptom ,Psychiatry ,business - Abstract
The efficacy of eltoprazine, a mixed 5-HT1 agonist, in treating aggressive behaviour in mentally handicapped patients was evaluated in a double-blind, placebo- and baseline-controlled study. In the total sample of 160 patients who entered the 8 week double-blind treatment phase, efficacy was not demonstrated. Also in a 28 week double-blind follow-up study, efficacy could not be demonstrated. Post-hoc exploratory analyses suggested eltoprazine was significantly better than placebo in reducing aggression scores of a subgroup of severely aggressive patients. There was no evident relationship between the plasma level of eltoprazine and therapeutic effect or safety and tolerance. The overall safety and tolerance of chronic eltoprazine treatment was good. In the discussion, several issues and pitfalls of aggression research are dealt with.
- Published
- 1994
6. Neighbourhood income gradients in hospitalisations due to motor vehicle traffic incidents among Canadian children
- Author
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L Oliver and D Kohen
- Subjects
Male ,Automobile Driving ,Canada ,Adolescent ,Poison control ,Pedestrian ,Rural Health ,Suicide prevention ,Occupational safety and health ,Transport engineering ,Young Adult ,Residence Characteristics ,Risk Factors ,Injury prevention ,Humans ,Child ,Neighbourhood (mathematics) ,Public Health, Environmental and Occupational Health ,Accidents, Traffic ,Urban Health ,Human factors and ergonomics ,Infant ,Hospital Records ,Bicycling ,Hospitalization ,Motor Vehicles ,Geography ,Child, Preschool ,Income ,Wounds and Injuries ,Female ,Rural area ,Demography - Abstract
Objective: To investigate income gradients in motor vehicle traffic injury hospitalisation for vehicle occupants and pedestrians/cyclists among children in urban and rural Canada. Design: Four years (2001/02–2004/05) of acute-care hospitalisation discharge records for children aged 0–19 years were analysed. International Classification of Disease codes were used to determine hospitalisations due to motor vehicle traffic incidents for occupants and pedestrians/cyclists. Rates of injury (per 10 000 person years) were calculated by neighbourhood income quintiles for urban and rural areas. Results: Among children (0–19 years), rates of vehicle occupant hospitalisation were higher in rural (5.07, 95% CI 4.90 to 5.25) than urban areas (2.08, 95% CI 2.03 to 2.14). In rural areas, children from lower income neighbourhoods had higher vehicle occupant hospitalisation rates than those from the richest neighbourhoods (5.52, 95% CI 5.13 to 5.93 vs 4.30, 95% CI 3.97 to 4.66). In urban areas vehicle occupant hospitalisation rates were similar among children from the poorest and richest neighbourhoods—but higher among children from middle income neighbourhoods. In urban areas, but not rural areas, the hospitalisation rate for pedestrians/cyclists systematically increased with decreasing neighbourhood income. In urban areas the pedestrian/cyclist hospitalisation rate was four times higher for children from the poorest (1.40, 95% CI 1.25 to 1.57) than from the richest (0.34, 95% CI 0.28 to 0.43) neighbourhoods. Conclusions: While vehicle occupant and pedestrian/cyclist motor vehicle traffic injuries are more frequent among children from lower income neighbourhoods, gradients are most pronounced for pedestrians/cyclists in urban areas.
- Published
- 2009
7. Survey of psychotropic medication: usage in a large mental handicap hospital
- Author
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D. Kohen, G. Mathew, and L. Fernando
- Subjects
medicine.medical_specialty ,education.field_of_study ,business.industry ,Population ,Total population ,Psychotropic medication ,Mental handicap ,Psychiatry and Mental health ,Pedagogy ,medicine ,Closure (psychology) ,Psychiatry ,business ,education - Abstract
The populations in the large mental handicap hospitals arc known to be diverse, ranging from elderly non-psychiatric residential groups to acutely psychotic and behaviourally disturbed patients. At present demographic variables, medical and psychi atric characteristics of populations in these hospitals are changing in parallel with implementation of community care and resettlement programmes. In resettlement programmes, discharge priorities have been given to the easy to manage and less dependent residents while new challenging behavioural units and admission assessment wards are being opened to care for the multi-handicapped population. The use of psychotropic medication in this population has been under constant debate. While some drugs have probably been over prescribed, others have followed current trends in adult general psychiatry and fluctuated accordingly. The Cell Barnes Hospital Psychiatric Database (CBH-PD) was established in 1990 to evaluate, among other variables, the psychotropic medication usage in the total population of this large mental handicap hospital before closure and to form a basis in comparison with future surveys of the same population in the community.
- Published
- 1993
8. A five-year follow-up study of older long-stay clients with intellectual disability using the Disability Assessment Schedule
- Author
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M. Orrell, D. Kohen, G. Mathew, O. Ashaye, and L. Fernando
- Subjects
Gerontology ,Male ,medicine.medical_specialty ,Echolalia ,Down syndrome ,medicine.medical_treatment ,Population ,Arts and Humanities (miscellaneous) ,Intellectual Disability ,Intellectual disability ,Activities of Daily Living ,medicine ,Humans ,education ,Geriatric Assessment ,Aged ,Aged, 80 and over ,education.field_of_study ,Rehabilitation ,Public health ,Social Behavior Disorders ,Middle Aged ,medicine.disease ,Mental health ,Long-Term Care ,Social relation ,Patient Discharge ,Psychiatry and Mental health ,Treatment Outcome ,Neurology ,Female ,Neurology (clinical) ,medicine.symptom ,Psychology ,Social Adjustment ,Follow-Up Studies - Abstract
The emphasis on community care means closure of the long-stay institutions for people with intellectual disability. Studies have indicated that older people with intellectual disability in particular may not be adequately cared for because of poor monitoring of their changing needs and inadequate provision of services. The use of rating instruments to monitor changes, and to predict outcome or needs in this population may help to improve care by assisting with planning and projection of service requirements. In 1991, all residents of a long-stay hospital for people with intellectual disability were assessed using the Disability Assessment Schedule (DAS). Five years later, the 1991 scores of the older residents (aged > 50 years) were reviewed and compared under three outcome groups: in-patients, discharged and deceased. Furthermore, all older people resident in the hospital in 1996 were reassessed using the DAS. Out of the 144 older clients resident in 1991, five years later, 78 were still in-patients, 38 had been discharged into the community and 28 were deceased. In 1991, the deceased group had the greatest problems with continence and symbolic behaviour, while the discharged group had the greatest problems with self-help, vision, hearing, communication, social interaction, echolalia and repetitive speech. In comparison with 1991, the 1996 DAS scores of older residents showed that there were increasing problems with vision, hearing, communication, behaviour and symbolic activities. The present study suggested that the DAS is a useful instrument for monitoring change and predicting outcome in older people with intellectual disability.
- Published
- 1998
9. The role of anxiety and depression in quality of life and symptom reporting in people with diabetes mellitus
- Author
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D, Kohen, A P, Burgess, J, Catalán, and A, Lant
- Subjects
Adult ,Male ,Depressive Disorder ,Middle Aged ,Anxiety Disorders ,Severity of Illness Index ,Affect ,Diabetes Mellitus, Type 1 ,Diabetes Mellitus, Type 2 ,Case-Control Studies ,Surveys and Questionnaires ,Activities of Daily Living ,Quality of Life ,Health Status Indicators ,Humans ,Female ,Aged - Abstract
Although quality of life evaluations are widely used throughout medicine, relatively little is known about the psychological processes involved in making these judgements. What is known is that quality of life judgements are not straightforwardly associated with objective measures of health status or clinician ratings. In particular, patient affect appears to be associated with quality of life ratings but whether this relationship is secondary to physical health or not is controversial. The aim of this study was to determine the role of anxiety and depression in the reporting of quality of life in a group of patients with diabetes mellitus. One hundred consecutive patients with diabetes (insulin-dependent diabetes mellitus n = 36 and non-insulin-dependent diabetes n = 64) were assessed using a self-report measure of quality of life, a symptom checklist and a questionnaire measure of anxiety and depression. In addition, they were independently rated for their level of physical impairment. The results showed that depression and, to a lesser extent, anxiety were significantly related to self-reported quality of life even when the differences in physical health and age were controlled for statistically. This study shows that, independent of the level of physical illness, affect, particularly depressive affect, is an important factor in the determination of quality of life.
- Published
- 1998
10. Neuroleptic malignant syndrome
- Author
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M F, Bristow and D, Kohen
- Subjects
Diagnosis, Differential ,Risk Factors ,Mental Disorders ,Dopamine Antagonists ,Humans ,Neuroleptic Malignant Syndrome ,Antipsychotic Agents ,Receptors, Dopamine - Abstract
Neuroleptic malignant syndrome is a rare, idiosyncratic condition related to neuroleptic use which may develop at any stage during neuroleptic treatment and can prove fatal. Although most commonly seen in psychiatric patients, anyone prescribed a neuroleptic is at risk and it has been associated with other agents. This article discusses its recognition, risk factors, clinical course and treatment, together with a summary of current thinking on its aetiology.
- Published
- 1996
11. Neuroleptics in learning disability. Other psychotropic drugs used sparingly
- Author
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D Kohen
- Subjects
medicine.medical_specialty ,Health Knowledge, Attitudes, Practice ,Letter ,business.industry ,Learning Disabilities ,Decision Making ,General Engineering ,Alternative medicine ,General Medicine ,Workload ,Community Mental Health Services ,Learning disability ,Practice Guidelines as Topic ,General Earth and Planetary Sciences ,Medicine ,Humans ,medicine.symptom ,business ,Psychiatry ,Family Practice ,General Environmental Science ,Antipsychotic Agents - Abstract
Recent papers have again highlighted the consistently high use of neuroleptic agents among people with a learning disability, despite the lack of good evidence to support their role in this population for behaviour management and despite the risks of such medication. Evidence suggests, however, that prescribing habits have remained relatively unchanged; the reasons for this are poorly understood. Given the lack of understanding about the factors contributing to such drug use, and the possibility that use of neuroleptics will increase as people with learning disabilities move into the community, there seems a clear need for clinical guidelines to cover the prescribing and monitoring of neuroleptics within this group. Such guidelines should also ensure that reviews, using reliable measures of treatment efficacy, are carried out regularly.
- Published
- 1993
12. Atypical antipsychotics and neuroleptic malignant syndrome
- Author
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M F Bristow and D Kohen
- Subjects
Dibenzothiazepines ,medicine.medical_specialty ,business.industry ,Pirenzepine ,medicine.disease ,Dermatology ,Neuroleptic malignant syndrome ,Benzodiazepines ,Quetiapine Fumarate ,Psychiatry and Mental health ,Olanzapine ,medicine ,Humans ,Neuroleptic Malignant Syndrome ,business ,Antipsychotic Agents - Published
- 1999
13. Mental health issues of turkish female immigrants residing in the UK - A follow-up study
- Author
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D. Kohen
- Subjects
Gerontology ,Psychiatry and Mental health ,Turkish ,business.industry ,media_common.quotation_subject ,Immigration ,Follow up studies ,language ,Medicine ,business ,Mental health ,language.human_language ,media_common - Published
- 2008
14. The evolution of the psychiatric out-patient clinic
- Author
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D. Kohen, D. Hollander, and N. S. Harvey
- Subjects
Psychiatry and Mental health ,medicine.medical_specialty ,business.industry ,medicine ,Psychiatry ,business ,Out patient clinic - Published
- 2000
15. Supervised discharge is anachronistic
- Author
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Timothy G. Dinan, P Nayer, D Kohen, P Caviston, James V. Lucey, N Boast, R Seifert, E Akuffo, M Salter, S Murphy, L Petterson, Trevor Turner, and M Deahl
- Subjects
Patient discharge ,medicine.medical_specialty ,Letter ,business.industry ,Mentally ill ,Mental Health Act ,General Engineering ,Legislature ,General Medicine ,Community Mental Health Services ,Patient Discharge ,United Kingdom ,Officer ,medicine ,Humans ,General Earth and Planetary Sciences ,Anachronism ,Psychiatry ,business ,Deinstitutionalization ,General Environmental Science - Abstract
EDITOR,—Some readers may be unaware that on 1 April an amendment to the 1983 Mental Health Act came into force. This gives to psychiatrists—known in legislative parlance as the responsible medical officer or, more alarmingly, the community responsible medical officer—new powers for the “supervisions” of mentally ill patients, termed supervised discharge. This act, however, confers no additional therapeutic powers for treating people with an illness. On the contrary, it gives powers that might …
- Published
- 1996
16. Key Issues in Mental Retardation Research. Edited by William I. Fraser London: Routledge. 1990. 506 pp. £50.00
- Author
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D. Kohen
- Subjects
Psychiatry and Mental health ,Anthropology ,Sociology ,Key issues - Published
- 1992
17. [No Title]
- Author
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D. Kohen, S. Attale, and G. Mathew
- Subjects
Psychiatry and Mental health - Published
- 1992
18. Motor disorders of the mentally handicapped
- Author
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G Mathew and D Kohen
- Subjects
Psychiatry and Mental health ,medicine.medical_specialty ,Text mining ,business.industry ,medicine ,business ,Psychiatry ,Psychology - Published
- 1991
19. Dyskinesia in the mentally handicapped
- Author
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G Mathew and D Kohen
- Subjects
Psychiatry and Mental health ,medicine.medical_specialty ,Dyskinesia ,business.industry ,Medicine ,medicine.symptom ,business ,Psychiatry - Published
- 1990
20. Importance of basic sciences to education in psychiatry
- Author
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D. Kohen
- Subjects
Psychiatry and Mental health ,Medical education ,medicine.medical_specialty ,business.industry ,Medicine ,business ,Psychiatry - Published
- 1990
21. Retinal pigment epithelial detachments in the elderly: classification and outcome
- Author
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Alan C. Bird, D Kohen, and A G Casswell
- Subjects
medicine.medical_specialty ,Visual acuity ,genetic structures ,Visual Acuity ,Drusen ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,Ophthalmology ,medicine ,Humans ,Fluorescein Angiography ,Pigment Epithelium of Eye ,Aged ,Neovascularization, Pathologic ,medicine.diagnostic_test ,business.industry ,Retinal Detachment ,Retinal Vessels ,Retinal detachment ,Retinal ,Anatomy ,Middle Aged ,Prognosis ,Fluorescein angiography ,medicine.disease ,eye diseases ,Sensory Systems ,chemistry ,Epithelial atrophy ,Tears ,Retinal pigment epithelial detachment ,sense organs ,medicine.symptom ,business ,Research Article - Abstract
Sixty-four eyes of 57 elderly patients with pigment epithelial detachments (PEDs) were studied with the aim of describing their morphological features and identifying prognostic factors. They were classified into four groups according to the following characteristics: early fluorescence, late fluorescence, shallow detachment with limited fluorescence ('drusen type'), irregular fluorescence. The following conclusions were drawn: 30% developed demonstrable subretinal new vessels; all groups except the drusen type were susceptible, the irregular group being particularly prone. 10% developed retinal pigment epithelial tears, and these occurred almost exclusively in the slow fluorescent group. Flattening of PEDs was a feature of drusen type and early fluorescent groups. Most patients lost vision. RPE tears occurred within a few months of presentation with immediate loss of vision; likewise rapid loss of vision followed the development of demonstrable new vessels, though not necessarily in those with changes thought to imply the presence of new vessels. Flattening after prolonged detachment was associated with pigment epithelial atrophy and invariable loss of vision. Visual acuity was maintained consistently only in those eyes with persistent detachment.
- Published
- 1985
22. [Uveitis in a Yersinia pseudotuberculosis infection--one case]
- Author
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P, Girard, J J, Saragoussi, C, Merlet, Y, Bokobza, D, Kohen, and A, Forest
- Subjects
Male ,Uveitis ,Optic Neuritis ,Yersinia Infections ,HLA Antigens ,Arthritis ,Humans ,Yersinia pseudotuberculosis Infections ,Spondylitis, Ankylosing ,Middle Aged - Published
- 1982
23. [Retinal detachment following extraction of an intraocular foreign body. Effects of vitrectomy]
- Author
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F, Barthelemy, P, Girard, J F, Bonnissent, and D, Kohen
- Subjects
Adult ,Male ,Postoperative Complications ,Adolescent ,Eye Foreign Bodies ,Vitrectomy ,Retinal Detachment ,Humans ,Female ,Middle Aged ,Aged - Abstract
Intra-ocular foreign bodies have an extremely poor prognosis, retinal detachment with vitreo-retinal retraction being the main factor of treatment failure. Vitrectomy appears to be an effective method for preventing this complication. 77 patients with intra-ocular foreign bodies were studied in two separate groups: 45 patients in group I did not have preventive vitrectomy and 23 developed retinal detachments; 32 patients in group II did have preventive vitrectomy within 3 weeks following foreign body extraction, and only 6 patients developed retinal detachment. Vitreous hemorrhage and cataract were present in all cases with retinal detachment. The retinal detachment rate was significatively different between group I and II. Early vitrectomy seems to be effective in preventing retinal detachment after an intra-ocular foreign body. However, others factors still have to be studied: cataract, hemorrhage, contusion.
- Published
- 1983
24. [Acute retinal necrosis and ocular toxoplasmosis]
- Author
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P, Girard, D, Kohen, C, Chevalier, and A, Forest
- Subjects
Adult ,Aqueous Humor ,Male ,Necrosis ,Chorioretinitis ,Acute Disease ,Retinal Detachment ,Humans ,Toxoplasmosis, Ocular ,Retina - Published
- 1984
25. [Three cases of conjunctival epithelioma]
- Author
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G, Payeur, J J, Rueff, D, Kohen, and A, Buemi
- Subjects
Cornea ,Male ,Carcinoma ,Humans ,Conjunctival Neoplasms ,Middle Aged - Published
- 1979
26. [Retinal detachment recurrences. 1. Frequency and risk factors (author's transl)]
- Author
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P, Girard, Y, Bokobza, A, Rouillac, D, Kohen, and A, Forest
- Subjects
Male ,Risk ,Vitreous Body ,Sex Factors ,Time Factors ,Recurrence ,Retinal Detachment ,Drainage ,Humans ,Infant ,Female ,Middle Aged ,Retrospective Studies - Abstract
Retinal detachment recurrence is defined the reappearance of a detachment after an initial complete success, whatever the delay between surgery and recurrence. This eliminates immediate failures due to inadequate buckles or major complications during surgery, exsudative retinal detachments that reattach spontaneously within a few days and cases where it is not sure that the retina had been completely reattached initially (cloudy media). Employing these criteria, a retrospective study demonstrated 130 eyes with recurrences out of a total of 1237 eyes operated between 1-10-69 and 31-12-79 (10,5 per cent rate); recurrences occurred in this series between 3 days and 7 years after initial surgery, 53,5 per cent of them within an interval of less than 3 months. The most important recurrence risk factors appear to be: detachment due to a retinal tear and not a hole, bullous detachment, abnormal vitreous but not full blown, massive vitreo-retinal retraction and massive intraocular bleeding during subretinal fluid drainage.
- Published
- 1982
27. Jaundice due to a rare cause: tuberculous lymphadenitis
- Author
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M D, Kohen and K A, Altman
- Subjects
Adult ,Cholestasis ,Liver ,Biopsy ,Isoniazid ,Humans ,Bilirubin ,Female ,Tuberculosis, Lymph Node ,Alkaline Phosphatase ,Ethambutol - Published
- 1973
28. Supervised discharge is anachronistic.
- Author
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H, Turner T, E, Akuffo, P, Caviston, T, Dinan, M, Deahl, D, Kohen, J, Lucey, S, Murphy, P, Nayer, L, Petterson, M, Salter, R, Seifert, and N, Boast
- Published
- 1996
29. Enhancing Lessons on the Internet of Things in Science, Technology, Engineering, and Medical Education with a Remote Lab.
- Author
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Amador Nelke S, Kohen-Vacs D, Khomyakov M, Rosienkiewicz M, Helman J, Cholewa M, Molasy M, Górecka A, Gómez-González JF, Bourgain M, Sagar A, Berselli G, Blank D, Winokur M, and Benis A
- Subjects
- Humans, Education, Distance methods, Engineering education, Science education, Technology education, Artificial Intelligence, Laboratories, Software, Internet of Things, Education, Medical methods
- Abstract
Integrating remote Internet of Things (IoT) laboratories into project-based learning (PBL) in higher education institutions (HEIs) while exploiting the approach of technology-enhanced learning (TEL) is a challenging yet pivotal endeavor. Our proposed approach enables students to interact with an IoT-equipped lab locally and remotely, thereby bridging theoretical knowledge with practical application, creating a more immersive, adaptable, and effective learning experience. This study underscores the significance of combining hardware, software, and coding skills in PBL, emphasizing how IoTRemoteLab (the remote lab we developed) supports a customized educational experience that promotes innovation and safety. Moreover, we explore the potential of IoTRemoteLab as a TEL, facilitating and supporting the understanding and definition of the requirements of remote learning. Furthermore, we demonstrate how we incorporate generative artificial intelligence into IoTRemoteLab's settings, enabling personalized recommendations for students leveraging the lab locally or remotely. Our approach serves as a model for educators and researchers aiming to equip students with essential skills for the digital age while addressing broader issues related to access, engagement, and sustainability in HEIs. The practical findings following an in-class experiment reinforce the value of IoTRemoteLab and its features in preparing students for future technological demands and fostering a more inclusive, safe, and effective educational environment.
- Published
- 2024
- Full Text
- View/download PDF
30. Work precarity, employment characteristics and health among Canada's long-term care and seniors' home workers during the COVID-19 pandemic.
- Author
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Antonipillai V, Ng E, Baumann A, Crea-Arsenio M, and Kohen D
- Subjects
- Humans, Long-Term Care, Pandemics, Canada epidemiology, Employment, COVID-19
- Abstract
Background: The COVID-19 pandemic has highlighted several issues among health care workers in Canada's long-term care and seniors' (LTCS) homes, including labour shortages, staff retention difficulties, overcrowding, and precarious working conditions. There is currently a lack of information on the health, well-being and working conditions of health care workers in LTCS homes - many of them immigrants - and a limited understanding of the relationship between them. This paper examines differences between immigrant and non-immigrant workers' health outcomes and precarious working conditions during the pandemic., Data and Methods: The data were from the 2021 Survey on Health Care Workers' Experiences During the Pandemic, which collected information on LTCS home health care workers' (n=2,051) health, employment or work experiences, and working environment during the COVID-19 pandemic. Summary statistics and multivariable logistic regressions were conducted to examine the association between precarious work and workers' health (life stress, mental health and general health), stratified by immigrant status. Selected working characteristics were included in the regression models as covariates, namely occupation, number of locations worked, facility ownership status and number of years worked., Results: Immigrant health care workers were more likely than non-immigrant health care workers to experience precarious work in LTCS homes. Precarious work - characterized by income loss, reduced hours of work, and unpaid leave - was associated with stress and poor general health among immigrant and non-immigrant workers in the sector. Employment precarity was also associated with poor mental health for immigrant workers, but there was no association for non-immigrant workers., Interpretation: Employment precarity and the health and well-being of health care workers warrants further attention, in particular among immigrants employed in the LTCS residential care sector.
- Published
- 2024
- Full Text
- View/download PDF
31. Childhood-onset disabilities and lifetime earnings growth: A longitudinal analysis.
- Author
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Jeon SH, Park J, and Kohen D
- Subjects
- Humans, Male, Child, Canada, Retirement, Social Security, Income, Disabled Persons
- Abstract
This study offers insights into lifetime earnings growth differences between individuals with and without childhood-onset disabilities (COD) defined as disabilities whose onset occurred before an individual's 16th birthday. We use a newly available database linking data from the 2017 Canadian Survey of Disability with individual income tax records covering a period of over 3 decades. We estimate the average earnings growth profiles of individuals with COD from the age when individuals generally enter the labor market to the age when most retire. The main finding of our study is that individuals with COD experience very little earnings growth when they are in their mid-30 and 40s while the earnings of those without COD grow steadily until they reach their late 40s and early 50s. The largest earnings growth differences between individuals with and without COD are observed for male university graduates., (© 2023 His Majesty the King in Right of Canada. Health Economics © 2023 John Wiley & Sons Ltd.)
- Published
- 2023
- Full Text
- View/download PDF
32. Childhood Abuse, Intimate Partner Violence in Young Adulthood, and Welfare Receipt by Midlife.
- Author
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Domond P, Orri M, Vergunst F, Bouchard S, Findlay L, Kohen D, Hébert M, Vitaro F, Tremblay RE, Geoffroy MC, and Côté S
- Subjects
- Adult, Middle Aged, Female, Child, Humans, Young Adult, Adolescent, Male, Longitudinal Studies, Retrospective Studies, Surveys and Questionnaires, Prevalence, Risk Factors, Child Abuse, Intimate Partner Violence
- Abstract
Objective: To investigate prospective associations between type of child abuse (physical, sexual, both), timing (childhood, young adulthood, both), and welfare receipt into middle-age., Methods: Database linkage study using the Quebec Longitudinal Study of Kindergarten Children cohort born in 1980 and government administrative databases (N = 3020). We assessed parental tax returns, family and personal background characteristics (1982-1987). At age 22 years, participants answered retrospective questionnaires on experienced childhood abuse (physical, sexual abuse < age 18 years) and intimate partner violence (IPV) (ages 18-22). Main outcome was years on social assistance, on the basis of participant tax returns (ages 23-37 years). Analysis included weights for population representativeness., Results: Of 1690 participants (54.4% females) with available data, 22.4% reported childhood abuse only, 14.5% IPV only, and 18.5% both. Prevalence of childhood physical, sexual, and both was 20.4%, 12.2%, and 8.3%, respectively. Adjusting for socioeconomic background and individual characteristics, we found that childhood physical abuse alone and physical or sexual abuse combined were associated with a two-fold risk of welfare receipt, as compared to never-abused (adjusted incidence risk ratio 2.43, 95% confidence interval [CI], 1.65-3.58; and adjusted incidence risk ratio 2.04, 95% CI, 1.29-3.23, respectively). Repeated abuse (childhood abuse combined with adult IPV) had a three-fold risk (adjusted incidence ratio 3.59, 95% CI, 2.39-5.37)., Conclusions: Abuse across several developmental periods (childhood and young adulthood) is associated with increased risks of long-term welfare receipt, independently of socioeconomic background. Results indicate a dose-response association. Early prevention and targeted identification are crucial to preventing economic adversity that may potentially lead to intergenerational poverty., (Copyright © 2023 by the American Academy of Pediatrics.)
- Published
- 2023
- Full Text
- View/download PDF
33. Cobalt Silylenes as Platforms for Catalytic Nitrene-Group Transfer by Metal-Ligand Cooperation.
- Author
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Whited MT, Han W, Jin-Lee HJ, DiNardo Z, Watson E, Zhang J, and Kohen D
- Abstract
A powerful approach to cooperative group-transfer catalysis is demonstrated using the Co=Si bond of a cobalt silylene to provide two distinct sites for substrate activation. The orthogonal selectivity of the Co and Si centers enables efficient nitrene-group transfer to carbon monoxide by avoiding poisoning that would result from substrates competing for a single reactive site., (© 2022 Wiley-VCH GmbH.)
- Published
- 2022
- Full Text
- View/download PDF
34. Bimetallic, Silylene-Mediated Multielectron Reductions of Carbon Dioxide and Ethylene.
- Author
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Whited MT, Zhang J, Conley AM, Ma S, Janzen DE, and Kohen D
- Abstract
A metal/ligand cooperative approach to the reduction of small molecules by metal silylene complexes (R
2 Si=M) is demonstrated, whereby silicon activates the incoming substrate and mediates net two-electron transformations by one-electron redox processes at two metal centers. An appropriately tuned cationic pincer cobalt(I) complex, featuring a central silylene donor, reacts with CO2 to afford a bimetallic siloxane, featuring two CoII centers, with liberation of CO; reaction of the silylene complex with ethylene yields a similar bimetallic product with an ethylene bridge. Experimental and computational studies suggest a plausible mechanism proceeding by [2+2] cycloaddition to the silylene complex, which is quite sensitive to the steric environment. The CoII /CoII products are reactive to oxidation and reduction. Taken together, these findings demonstrate a strategy for metal/ligand cooperative small-molecule activation that is well-suited to 3d metals., (© 2020 Wiley-VCH GmbH.)- Published
- 2021
- Full Text
- View/download PDF
35. Patients' experiences on adverse drug reactions reporting: a qualitative study.
- Author
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Al Dweik R, Yaya S, Stacey D, and Kohen D
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Canada epidemiology, Drug-Related Side Effects and Adverse Reactions etiology, Female, Humans, Male, Middle Aged, Qualitative Research, Social Media statistics & numerical data, Young Adult, Adverse Drug Reaction Reporting Systems statistics & numerical data, Drug-Related Side Effects and Adverse Reactions epidemiology, Health Knowledge, Attitudes, Practice
- Abstract
Background: Spontaneous reporting of adverse drug reactions (ADRs) is an important source of information for post-marketing drug safety evaluation. Most countries have public access to reporting systems, but patients report only 3% of all ADRs. Little is known about factors affecting patient reporting. Our aim was to explore patients' experiences reporting ADRs and their views on the usability of the Canadian Vigilance reporting forms on MedEffect., Methods: An interpretive description qualitative study was used. Adults in Canada, who experienced an ADR, were invited to participate through social media (Kijiji, Facebook, Twitter) and by associations (e.g., Patients Canada or Canadian Arthritis Society). Participants were interviewed in English and French using structured interview guides. Inductive content analysis was used., Results: Fifteen interviews were conducted from October 2014 to May 2015. Two participants reported ADRs to MedEffect, and others to physicians and/or pharmacists. Motives for reporting were intolerable side effect impacting daily activities and encouragement from others to report (e.g., family, colleagues). Factors that interfered with reporting were physicians normalized or minimized the side effect, confusion on what to report, no feedback after report submission to MedEffect, and previous experience with side effects. MedEffect forms were described as comprehensive and important, but its usability was affected by the number of questions and complexity of some questions., Conclusions: Most participants were unaware of MedEffect and reported ADRs to physicians and pharmacists. Several barriers and motives affected patients' reporting of ADRs. MedEffect form could be simplified for use by patients.
- Published
- 2020
- Full Text
- View/download PDF
36. Child Care Attendance and Educational and Economic Outcomes in Adulthood.
- Author
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Domond P, Orri M, Algan Y, Findlay L, Kohen D, Vitaro F, Tremblay RE, and Côté SM
- Subjects
- Adolescent, Adult, Child Day Care Centers, Child, Preschool, Female, Follow-Up Studies, Humans, Infant, Male, Prospective Studies, Young Adult, Academic Success, Child Care statistics & numerical data, Employment statistics & numerical data, Income statistics & numerical data
- Abstract
Objectives: To test associations between onset of formal child care (in infancy or as a toddler), high school graduation, and employment earnings from ages 18 to 35 years., Methods: A 30-year prospective cohort follow-up study, with linkage to government administrative databases ( N =3020). Exposure included formal child care, if any, by accredited caregivers in centers or residential settings at ages 6 months and 1, 1.5, 2, 3, and 4 years. A propensity score analysis was conducted to control for social selection bias., Results: Of 2905 participants with data on child care use, 59.4% of male participants and 78.5% of female participants completed high school by age 22 to 23. Mean income at last follow-up ( n = 2860) was $47 000 (Canadian dollars) (SD = 37 700) and $32 500 (SD = 26 800), respectively. Using group-based trajectory modeling, we identified 3 groups: formal child care onset in infancy (∼6 months), formal child care onset as a toddler (after 2.5 years), and never exposed. After propensity score weighting, boys with child care started in infancy had greater odds of graduating than those never exposed (odds ratio [OR] 1.39; 95% confidence interval [CI]: 1.18-1.63; P < .001). Boys attending child care had reduced odds of low income as young adults (infant onset: OR 0.60 [95% CI: 0.46-0.84; P < .001]; toddler onset: OR 0.63 [95% CI: 0.45-0.82; P < .001]). Girls' graduation rates and incomes revealed no significant association with child care attendance., Conclusions: For boys, formal child care was associated with higher high school completion rates and reduced risk of adult poverty. Benefits for boys may therefore extend beyond school readiness, academic performance, and parental workforce participation., Competing Interests: POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose., (Copyright © 2020 by the American Academy of Pediatrics.)
- Published
- 2020
- Full Text
- View/download PDF
37. Understanding the Perceived Mental Health of Canadians During the COVID-19 Pandemic.
- Author
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Findlay LC, Arim R, and Kohen D
- Subjects
- Adolescent, Adult, Age Factors, Aged, Betacoronavirus isolation & purification, COVID-19, Canada epidemiology, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, SARS-CoV-2, Sex Factors, Socioeconomic Factors, Surveys and Questionnaires, Chronic Disease psychology, Coronavirus Infections epidemiology, Health Status, Mental Health, Pandemics, Pneumonia, Viral epidemiology
- Abstract
Background: While the physical health implications of the COVID-19 pandemic are regularly publicly available, the mental health toll on Canadians is unknown. This article examines the self-perceived mental health of Canadians during the COVID-19 pandemic and explores associations with various concerns after accounting for socioeconomic and health factors., Data: The cross-sectional Canadian Perspectives Survey Series 1 collected information related to COVID-19 in late March and early April 2020 concerning labour market participation, behaviours, and health for the Canadian population 15 years and older living in the 10 provinces., Methods: Socioeconomic and health characteristics of respondents as well as concerns about the impact of COVID-19 were examined to determine differences in experiencing excellent or very good compared to good, fair or poor perceived mental health., Results: Just over half of Canadians aged 15 and older (54%) reported excellent or very good mental health during the COVID-19 pandemic. Several concerns were also associated with mental health. Notably, after considering the effects of socioeconomic and health characteristics, women, youth, individuals with a physical health condition and those who were very or extremely concerned with family stress from confinement were less likely to report excellent or very good mental health., Discussion: These findings point to particular risks for lower perceived mental health during the COVID-19 pandemic. Results highlight various concerns of Canadians which may be associated with mental health, in particular, family stress in the home.
- Published
- 2020
- Full Text
- View/download PDF
38. Prescription Drug Use Among Adults Aged 40-79 in the United States and Canada.
- Author
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Hales CM, Servais J, Martin CB, and Kohen D
- Subjects
- Adult, Age Factors, Aged, Canada epidemiology, Female, Humans, Male, Middle Aged, Nutrition Surveys, United States epidemiology, Polypharmacy, Prescription Drugs
- Abstract
Patterns of prescription drug use may reflect underlying patterns of health conditions and health care access in the population. Polypharmacy, often defined as the simultaneous use of five or more prescription drugs, is more common in an aging population where multiple coexisting chronic conditions often occur; however, safety concerns may arise (1). The United States and Canada share many cultural and historical ties, but with different models for health care delivery (2). This report describes the use of one or more and five or more prescription drugs among adults aged 40-79 in the United States and Canada., (All material appearing in this report is in the public domain and may be reproduced or copied without permission; citation as to source, however, is appreciated.)
- Published
- 2019
39. Acute care hospitalizations for mental and behavioural disorders among First Nations people.
- Author
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Carrière G, Bougie B, and Kohen D
- Subjects
- Adolescent, Adult, Canada epidemiology, Censuses, Databases, Factual, Female, Humans, Male, Middle Aged, Young Adult, Hospitalization statistics & numerical data, Indians, North American statistics & numerical data, Inuit statistics & numerical data, Mental Disorders epidemiology
- Abstract
Background: National information about acute care hospitalizations for mental/behavioural disorders among Aboriginal people in Canada is limited., Data and Methods: This study describes acute care hospitalizations for mental /behavioural disorders among First Nations people living on and off reserve. The 2006 Census was linked to the Discharge Abstract Database from 2006/2007 through 2008/2009 for all provinces (except Ontario and Quebec) and the three territories. Hospitalizations for seven types of disorders were identified. "Most responsible" diagnosis and secondary diagnoses were examined separately. Age-standardized hospitalization rates (ASHRs) per 100,000 population and rate ratios were calculated., Results: ASHRs for most responsible and secondary diagnoses of mental/behavioural disorders were significantly higher for First Nations people living on and off reserve than for non-Aboriginal people. The leading diagnoses were the same for each group, but the rank order differed. Among First Nations people, the most common diagnoses were substance-related disorders, mood disorders, and schizophrenic/psychotic disorders. Among non-Aboriginal people, mood disorders were the leading most responsible diagnosis, followed by schizophrenic/psychotic disorders and substance-related disorders. The greatest rate differences between First Nations and non-Aboriginal people for both most responsible and secondary diagnoses were for substance-related disorders., Discussion: The higher burden of hospitalizations due to mental/behavioural disorders among First Nations people provides benchmarks and points to the need of considering every hospital admission as an important opportunity for intervention and prevention. The Truth and Reconciliation Commission of Canada (2015) has recognized that the poorer health outcomes of Aboriginal people in Canada were rooted in the legacies of colonization. Further research is required to better understand the direct impacts on mental health.
- Published
- 2018
40. The Job Content, Context, and Requirements of Regulated Home-Based Childcare Workers.
- Author
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Stitou M, Bourgeault IL, and Kohen D
- Subjects
- Adolescent, Adult, Canada, Child, Child Care statistics & numerical data, Child, Preschool, Female, Home Care Services statistics & numerical data, Humans, Infant, Infant, Newborn, Male, Middle Aged, Surveys and Questionnaires, Child Care legislation & jurisprudence, Child Care standards, Home Care Services legislation & jurisprudence, Home Care Services standards, Job Satisfaction
- Abstract
Contrary to a large and growing literature on center-based childcare workers, we know little about the work and health experiences of those providing childcare services in their homes. This study examines the job content, context, and requirements of regulated Home-Based Childcare workers in Canada. It is based on the qualitative analysis of eleven individual semistructured interviews. These workers perform business administration tasks and more housekeeping and domestic work than those in the center-based childcare, which affect their health and well-being. In addition, they reported factors related to the context and the content of their job such as the high physical and mental efforts, the absence of contact with other adults during working hours, the lack of external help, the exposure to noise and bad odors, the interference of work with personal and family life, the precarious remuneration, and the lack of benefits as potential factors that may affect their health.
- Published
- 2018
- Full Text
- View/download PDF
41. Acute care hospitalization of Aboriginal children and youth.
- Author
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Guèvremont A, Carrière G, Bougie E, and Kohen D
- Subjects
- Adolescent, Canada epidemiology, Censuses, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Patient Discharge, Young Adult, Acute Disease, Hospitalization statistics & numerical data, Indians, North American statistics & numerical data, Inuit
- Abstract
Background: Research that has examined Aboriginal children's hospitalization rates at the national level has been limited to analyses of areas with large percentages of Aboriginal residents, rather than of Aboriginal individuals. This study uses linked census and administrative data to describe hospitalization patterns among children and youth aged 0 to 19, by Aboriginal identity, for all provinces and territories except Quebec., Data and Methods: The 2006 Census was linked to the 2006/2007-to-2008/2009 Discharge Abstract Database, which contains hospital records from all acute care facilities (except Quebec). Hospital records were examined by Aboriginal identity, as reported to the census, according to International Classification of Diseases chapters based on "the most responsible diagnosis." Age-standardized hospitalization rates (ASHRs) were calculated per 100,000 population, and age-standardized rate ratios (RRs) were calculated for Aboriginal groups relative to non-Aboriginal people., Results: ASHRs were consistently higher among Aboriginal children and youth relative to their non-Aboriginal counterparts; rates for children aged 0 to 9 were 1.4 to 1.8 times higher; for youth aged 10 to 19, 2.0 to 3.8 times higher. For all children aged 0 to 9, the leading cause of hospitalization was "diseases of the respiratory system," but RRs for Aboriginal children ranged from 1.7 to 2.5, compared with non-Aboriginal children. Disparities between Aboriginal and non-Aboriginal 10- to 19-year-olds were pronounced for injuries due to assaults (RRs from 4.8 to 10.0), self-inflicted injuries (RRs from 2.7 to 14.2), and pregnancy, childbirth and the puerperium (RRs from 4.1 to 9.8)., Interpretation: Additional research is needed to examine reasons for the disparities in hospitalization rates between Aboriginal and non-Aboriginal children and youth.
- Published
- 2017
42. The Effects of Reducing Preparation Time on the Execution of Intentionally Curved Trajectories: Optimization and Geometrical Analysis.
- Author
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Kohen D, Karklinsky M, Meirovitch Y, Flash T, and Shmuelof L
- Abstract
When subjects are intentionally preparing a curved trajectory, they are engaged in a time-consuming trajectory planning process that is separate from target selection. To investigate the construction of such a plan, we examined the effect of artificially shortening preparation time on the performance of intentionally curved trajectories using the Timed Response task that enforces initiation of movements prematurely. Fifteen subjects performed obstacle avoidance movements toward one of four targets that were presented 25 or 350 ms before the "go" signal, imposing short and long preparation time conditions with mean values of 170 ms and 493 ms, respectively. While trajectories with short preparation times showed target specificity at their onset, they were significantly more variable and showed larger angular deviations from the lines connecting their initial position and the target, compared to the trajectories with long preparation times. Importantly, the trajectories of the short preparation time movements still reached their end-point targets accurately, with comparable movement durations. We hypothesize that success in the short preparation time condition is a result of an online control mechanism that allows further refinement of the plan during its execution and study this control mechanism with a novel trajectory analysis approach using minimum jerk optimization and geometrical modeling approaches. Results show a later agreement of the short preparation time trajectories with the optimal minimum jerk trajectory, accompanied by a later initiation of a parabolic segment. Both observations are consistent with the existence of an online trajectory planning process.Our results suggest that when preparation time is not sufficiently long, subjects execute a more variable and less optimally prepared initial trajectory and exploit online control mechanisms to refine their actions on the fly.
- Published
- 2017
- Full Text
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43. Factors affecting patient reporting of adverse drug reactions: a systematic review.
- Author
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Al Dweik R, Stacey D, Kohen D, and Yaya S
- Subjects
- Feedback, Health Knowledge, Attitudes, Practice, Humans, Motivation, Patients psychology, Adverse Drug Reaction Reporting Systems, Drug-Related Side Effects and Adverse Reactions, Self Report
- Abstract
Aim: The aim of the present study was to determine the barriers and motives influencing consumer reporting of adverse drug reactions (ADRs)., Methods: A systematic review, guided by the Cochrane Handbook, was conducted. Electronic searches included MEDLINE, EMBASE, PsycINFO, CINAHL, PubMed and the Cochrane Database of Systematic Reviews from 1964 to December 2014. Eligible studies addressed patients' perceptions and factors influencing ADR reporting. Studies about healthcare professional (HCP) reporting of ADRs were excluded. Studies were appraised for quality, and results were analysed descriptively., Results: Of 1435 citations identified, 21 studies were eligible. Studies were primarily conducted in the UK, the Netherlands and Australia. The identified barriers to patient reporting of ADRs (n = 15 studies) included poor awareness, confusion about who should report the ADR, difficulties with reporting procedures, lack of feedback on submitted reports, mailing costs, ADRs resolved and prior negative reporting experiences. The identified motives for patients reporting ADRs (n = 10 studies) were: preventing others from having similar ADRs, wanting personal feedback, improving medication safety, informing regulatory agencies, improving HCP practices, responding to HCPs not reporting their ADRs and having been asked to report ADRs by HCPs., Conclusions: Most patients were not aware of reporting systems and others were confused about reporting. Patients were mainly motivated to make their ADRs known to prevent similar suffering in other patients. By increasing patient familiarity and providing clear reporting processes, reporting systems could better achieve patient reporting of ADRs., (© 2016 The British Pharmacological Society.)
- Published
- 2017
- Full Text
- View/download PDF
44. Smoking prevalence among Inuit in Canada.
- Author
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Bougie E and Kohen D
- Subjects
- Adolescent, Adult, Age Factors, Aged, Canada epidemiology, Female, Humans, Male, Middle Aged, Prevalence, Sex Factors, Smoking Cessation, Young Adult, Inuit statistics & numerical data, Smoking epidemiology, Smoking trends
- Abstract
Using data from the 1991, 2001 and 2012 Aboriginal Peoples Survey, this study examines the prevalence of smoking among Inuit aged 15 or older, by location of residence, sex and age group. Overall, the prevalence of daily smoking was significantly lower in 2012 than in 1991; this was true for Inuit living inside and outside Inuit Nunangat, for men and women, for most age groups, and for those in all Inuit regions except Nunavik. The average number of cigarettes smoked per day by daily smokers decreased steadily and significantly over time, except among those living outside Inuit Nunangat or in Nunavik, and those aged 55 or older. The average age of daily smoking initiation remained stable at 15.
- Published
- 2017
45. A Theoretical Mechanistic Study of the Asymmetric Desymmetrization of a Cyclic meso-Anhydride by a Bifunctional Quinine Sulfonamide Organocatalyst.
- Author
-
Blise K, Cvitkovic MW, Gibbs NJ, Roberts SF, Whitaker RM, Hofmeister GE, and Kohen D
- Abstract
Cinchona alkaloids and their derivatives are widely used as organocatalysts in asymmetric synthesis. In particular, sulfonamide derivatives of cinchona alkaloids are highly enantioselective desymmetrization catalysts in the ring opening of a variety of cyclic anhydrides. To better understand the mechanism of catalysis, as well as to identify the basis for enantioselectivity by this catalyst, we have performed DFT calculations of this reaction with a cyclic meso anhydride. Herein, we report calculations for two reaction pathways, one concerted and one stepwise, for the production of each enantiomer of the desymmetrized product using the complete sulfonamide catalyst I. Our results are consistent with both the enantioselectivity of this transformation and the catalytic role of the quinuclidine moiety. We find that the stepwise pathway is the relevant pathway in the production of the major enantiomer. Our calculations highlight the role of differential distortion of the anhydride-methanol complex in the transition state as the factor leading to stereoselectivity.
- Published
- 2017
- Full Text
- View/download PDF
46. Acute care hospitalization by Aboriginal identity, Canada, 2006 through 2008.
- Author
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Carrière G, Bougie E, Kohen D, Rotermann M, and Sanmartin C
- Subjects
- Acute Disease, Adolescent, Adult, Aged, Canada epidemiology, Censuses, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Risk Factors, Hospitalization statistics & numerical data, Indians, North American, Inuit
- Abstract
Background: National data about acute care hospitalization of Aboriginal people are scarce. This study addresses that information gap by describing patterns of hospitalization by Aboriginal identity for leading diagnoses for all provinces and territories except Quebec., Data and Methods: The 2006 Census was linked to the 2006/2007-to-2008/2009 Discharge Abstract Database, which contains hospital records from all acute care facilities in Canada (excluding Quebec). With these linked data, hospital records could be examined by Aboriginal identity, as reported to the census. Hospitalizations were grouped by International Classification of Diseases (ICD-10) chapters based on "the most responsible diagnosis." Age-standardized hospitalization rates were calculated per 100,000 population, and rate ratios (RR) were calculated for Aboriginal groups relative to non-Aboriginal people., Results: Hospitalization rates were almost invariably higher for First Nations living on and off reserve, Métis, and Inuit living in Inuit Nunangat than for the non-Aboriginal population, regardless of ICD diagnostic chapter. The ranking of age-standardized hospitalization rates by frequency of diagnoses varied slightly by Aboriginal identity. RRs were highest among First Nations living on reserve, especially for endocrine, nutritional and metabolic diseases (RR = 4.9), mental and behavioural disorders (RR = 3.6), diseases of the respiratory system (RR = 3.3), and injuries (RR = 3.2). As well, the rate for endocrine, nutritional and metabolic diseases was high among First Nations living off reserve (RR = 2.7). RRs were also high among Inuit for mental and behavioural disorders (RR = 3.3) and for diseases of the respiratory system (RR = 2.7)., Interpretation: Hospitalization rates varied by Aboriginal identity, and were consistent with recognized health disparities between Aboriginal and non-Aboriginal people. Because many factors besides health affect hospital use, further research is required to understand differences in hospital use by Aboriginal identity. These national data are relevant to health policy formulation and service delivery planning.
- Published
- 2016
47. Spontaneous adverse drug reaction reporting by patients in Canada: a multi-method study-study protocol.
- Author
-
Dweik RA, Yaya S, Stacey D, and Kohen D
- Abstract
Background: Monitoring adverse drug reactions (ADRs) through pharmacovigilance are vital to patient safety. Spontaneous ADR reporting is one method of pharmacovigilance, and in Canada all reporter types admitted to report an ADR to the Canadian Vigilance Program at Health Canada. Reports are submitted to Health Canada by post, telephone, or via the internet. The Canada Vigilance Program electronically records submitted information to detect medication safety alerts. Although previous studies have shown differences between patients and healthcare professionals (HCPs) on the types of drugs and reactions reported, relatively little is known about the importance of patient reports to pharmacovigilance activities. This article proposed a multi-method approach to evaluate the importance of patient ADR reporting on pharmacovigilance activities, by systematically review the available literature, comparing patient-versus HCPs-generated ADR reports that were submitted to the Canada Vigilance Program, and exploring patient views and experiences regarding the Canadian ADR reporting system., Methods: Guided by a risk-perception theoretical lens, the proposed multi-methods research study will involve three phases. Phase I is a systematic review of all studies that analyse the factors influence ADR reporting by patients to the pharmacovigilance schemes. Phase II is a descriptive statistical analysis of all ADR reports received by the Canada Vigilance Program database between 1 January 2000 and 31 December 2014 from patients and HCPs to compare ADRs reported by patients with those reported by HCP reports in terms of ADR seriousness, ADR classification by system organ class, and the medication involved based on the anatomical therapeutic class system. In phase III, an interpretative descriptive approach will be used to explore patient's views and experiences on ADR reporting and usability of the Canadian Vigilance ADR report. Participants will be purposefully selected to ensure diverse backgrounds and experiences. Interviews will be digitally-recorded, transcribed verbatim, and inductively analysed to identify themes. Patients will be interviewed until theoretical saturation is achieved., Discussion: Findings from this research will highlight the role of the patients in directly reporting ADRs, and provide information that may guide streamline and optimizing patient ADR reporting. Policy makers, public health officials, and regulatory agencies will require this critical information in order to improve medication safety in Canada and worldwide.
- Published
- 2016
- Full Text
- View/download PDF
48. The effect of different pretreatment methods of PMMA-based crowns on the long-term tensile bond strength to dentin abutments.
- Author
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Keul C, Kohen D, Eichberger M, Roos M, Gernet W, and Stawarczyk B
- Subjects
- Computer-Aided Design, Dental Restoration Failure, Dental Stress Analysis, Humans, In Vitro Techniques, Molar, Tensile Strength, Crowns, Dental Abutments, Dental Bonding methods, Dental Cements chemistry, Polymethyl Methacrylate chemistry, Resin Cements chemistry
- Abstract
Objectives: The objective of the study was to test the effect of different pretreatments on tensile bond strength (TBS) of adhesively bonded CAD/CAM-generated polymethyl methacrylate (PMMA) crowns to dentin., Materials and Methods: Two hundred human molars were prepared and divided into 20 groups (n = 10/group). PMMA crowns were pretreated thusly: Monobond Plus/Heliobond (MH), Visio.link (VL), Ambarino P60 (AM), VP connect (VP), and nontreated as control groups (CG). Two resin cements were used for cementation of crowns: Clearfil SA Cement (CSA) and Variolink II (VAR). TBS was measured initially (24 h water storage, 37 °C) and after aging (5,000 thermal cycles, 5/55 °C). TBS was analyzed using one-way ANOVA with Scheffé post hoc, unpaired Student t, Mann-Whitney U, Kruskal-Wallis H, and chi-squared tests., Results: Within CSA, pretreatment with MH and VL showed higher initial TBS compared with AM-treated groups. All other groups showed no statistical differences. For MH, VL, AM, and VP in combination with CSA, a negative impact of aging was observed (p < 0.001), whereas in all VAR groups, no impact was measured. Pretreatment with MH (p = 0.001) and VP (p = 0.008) presented higher initial TBS for CSA than for VAR. After aging, MH (p = 0.025) and VL (p = 0.034) cemented with VAR showed higher results than CSA., Conclusions: All tested groups showed very low TBS values. Pretreatments with MH, VL, and VP have minimally improved the tensile strength after aging., Clinical Relevance: Although the tensile strength results were low, crowns adhesively cemented with pretreatments with MH, VL, and VP showed, after aging, a higher tensile strength than nontreated groups.
- Published
- 2015
- Full Text
- View/download PDF
49. Intentional injury hospitalizations in geographical areas with a high percentage of Aboriginal-identity residents, 2004/2005 to 2009/2010.
- Author
-
Oliver LN, Finès P, Bougie E, and Kohen D
- Subjects
- Adolescent, Adult, Body Piercing statistics & numerical data, Canada epidemiology, Child, Child, Preschool, Demography, Drowning epidemiology, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Poisoning epidemiology, Sex Factors, Young Adult, Hospitalization statistics & numerical data, Indians, North American statistics & numerical data, Inuit statistics & numerical data, Self-Injurious Behavior ethnology, Violence ethnology
- Abstract
Introduction: This study describes rates of self-inflicted and assault-related injury hospitalizations in areas with a relatively high percentage of residents identifying as First Nations, Métis and Inuit, by injury cause, age group and sex., Methods: All separation records from acute in-patient hospitals for Canadian provinces and territories excluding Quebec were obtained from the Discharge Abstract Database. Dissemination areas with more than 33% of residents reporting an Aboriginal identity in the 2006 Census were categorized as high-percentage Aboriginal-identity areas., Results: Overall, in high-percentage Aboriginal-identity areas, age-standardized hospitalization rates (ASHRs) for self-inflicted injuries were higher among females, while ASHRs for assault-related injuries were higher among males. Residents of high-percentage Aboriginal-identity areas were at least three times more likely to be hospitalized due to a self-inflicted injury and at least five times more likely to be hospitalized due to an assault-related injury compared with those living in low-percentage Aboriginal-identity areas., Conclusion: Future research should examine co-morbidities, socio-economic conditions and individual risk behaviours as factors associated with intentional injury hospitalizations.
- Published
- 2014
50. Organized extracurricular activities: are in-school and out-of-school activities associated with different outcomes for Canadian youth?
- Author
-
Guèvremont A, Findlay L, and Kohen D
- Subjects
- Adolescent, Canada, Female, Health Surveys, Humans, Male, Socioeconomic Factors, Leisure Activities, Schools, Smoking epidemiology, Students statistics & numerical data, Substance-Related Disorders epidemiology
- Abstract
Background: Participation in extracurricular activities can have positive effects on youth, with greater participation associated with higher academic as well as better socioemotional and behavioral outcomes. Little research has examined differential effects of in-school and out-of-school activities., Methods: This study examines in-school and out-of-school extracurricular activities for 14- to 17-year-olds using a population-based sample of Canadian youth. Associations with socioemotional and academic outcomes, and having tried smoking, alcohol, and marijuana were examined., Results: Weekly participation in both in-school and out-of-school activities were associated with positive and negative outcomes. In particular, youth who participated in out-of-school activities or in both in-school and out-of-school activities had better socioemotional outcomes. Academic outcomes were associated with in-school and out-of-school sports and nonsport activities. Youth who participated weekly in nonsport activities regardless of the context (in-school or out-of-school) were less likely to have tried smoking, alcohol, or marijuana. However, weekly participation in in-school sports was associated with an increased likelihood of failing a course; youth who participated weekly in out-of-school sports were more likely to have tried alcohol., Conclusion: The findings suggest that participation in extracurricular activities, regardless of context, encourage positive youth development., (© 2014, American School Health Association.)
- Published
- 2014
- Full Text
- View/download PDF
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