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7 results on '"D, Ingletto"'

2. Autologous bone marrow transplantation as consolidation therapy in newly diagnosed non-Hodgkin's lymphoma: long-term outcome

Author

D Ingletto, M Lalle, and A Montuoro

Subjects
Adult, Male, Cancer Research, medicine.medical_specialty, Neutropenia, Time Factors, Adolescent, Disease, Transplantation, Autologous, Disease-Free Survival, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Intestinal Mucosa, Bone Marrow Transplantation, Neoplasm Staging, Retrospective Studies, Preparative Regimen, Stomatitis, business.industry, Lymphoma, Non-Hodgkin, Palliative Care, Mouth Mucosa, Induction chemotherapy, Cancer, Middle Aged, medicine.disease, Combined Modality Therapy, Thrombocytopenia, Surgery, Non-Hodgkin's lymphoma, Lymphoma, Life Support Care, Regimen, Treatment Outcome, medicine.anatomical_structure, Oncology, Female, Bone marrow, business
Abstract

Autologous bone marrow transplantation (ABMT) often produces durable remission in patients with intermediate-high grade non-Hodgkin's lymphoma (NHL). We present a retrospective review of 32 eligible newly diagnosed patients with NHL treated with conventional induction chemotherapy followed by ABMT consolidation therapy. These patients were treated in our department between 1984-1994 and followed up for 5-172 months with a median time of 82 months. In our patients the status of disease at transplant was 30 complete remissions and 2 partial remissions. All patients received a CBV-like high-dose preparative regimen. At 136 months the probability of disease-free survival (DFS) and overall (OS) is 66% and 70% respectively. Seven patients died from the disease. There was one case of toxicity related death. Our aim was to achieve a status of minimal disease and then consolidate it with high-dose polychemotherapy regimen. This study confirms that a significant number of patients with aggressive responding NHL can achieve prolonged RFS and OS after ABMT. Our data document the importance of long-term follow-up in interpreting the results of ABMT in NHL.

Published
2000
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4. Monitoring of treatment adherence with easypod™ in six Italian centers: a real-world experience.

Author

Cardinale GM, Pesce S, Ingletto D, Mariano M, Catucci A, Corciulo N, and Fidotti E

Subjects
Adolescent, Body Height drug effects, Child, Female, Growth Disorders drug therapy, Habits, Human Growth Hormone therapeutic use, Humans, Italy, Male, Patient Education as Topic, Recombinant Proteins therapeutic use, Retrospective Studies, Equipment and Supplies, Monitoring, Physiologic instrumentation, Treatment Adherence and Compliance
Abstract

Background: A poor adherence to r-hGH therapy is associated to a low growth rate in patients with growth deficiency. For this reason, the choice of an objective method, such as an electronic device, for monitoring treatment adherence is very important. This retrospective study evaluated the r-hGH treatment adherence of patients with growth deficiency, monitored through the easypod™ device., Methods: Data from 90 patients (52 males and 38 females; mean age at the end of the study: 11.9 years ±3.40) enrolled in six Italian centers, was collected from the beginning of the r-hGH therapy until the end of the study through the easypod™ device. The primary endpoint, i.e. treatment adherence, was the ratio between actual days of treatment and planned days of treatment. Secondary endpoints were: relationship between heights measured at the beginning and at the end of the study, the change of the height SDS and the growth rate., Results: Data from easypod™ showed that the mean adherence was 70±13%. The mean age-adjusted growth of the patients was 28.68±13.8 cm during the treatment period of 977 days, and the 6-month growth rate for the planned period was 3.78±8.1 cm. A positive correlation between the adherence rate and the change of the height SDS value was observed (P<0.0006)., Conclusions: The easypod™ device seems to be a valid tool for quickly identifying non-adherence habits, allowing physicians to implement actions focused on reinforcing the importance of treatment both for patients and caregivers.

Published
2019
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5. [HAIR-AN syndrome (HyperAndrogenism, Insulin Resistance, Acanthosis Nigricans) in an adolescent with Cohen's syndrome].

Author

Ingletto D, Ruggiero L, and De Sanctis V

Subjects
Acanthosis Nigricans diagnosis, Adolescent, Facial Expression, Fatty Liver complications, Fatty Liver diagnosis, Female, Humans, Hyperandrogenism diagnosis, Hypotension complications, Intellectual Disability complications, Intellectual Disability diagnosis, Obesity complications, Syndrome, Acanthosis Nigricans complications, Hyperandrogenism complications, Insulin Resistance
Published
2001

6. Primary plasmacytoma of the testis. A case report.

Author

Ingletto D, Compagnucci M, Grillo LR, and Montuoro A

Subjects
Aged, Fatal Outcome, Humans, Male, Plasmacytoma drug therapy, Plasmacytoma pathology, Testicular Neoplasms drug therapy, Testicular Neoplasms pathology
Abstract

The authors describe a case of multiple myeloma that developed several extraskeletal localizations. They evaluated the relation between the onset of the testicular tumor and the following myeloma characteristics: tumor burden, clinical phase, response to therapy and prognostic significance. The patient presented a rapid and dramatic clinical evolution of the disease with extensive spread also to the soft tissues of the abdominal wall. Chemotherapy did not achieve any effect and the patient died due to progression of the myeloma.

Published
1998
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