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1,508 results on '"D'Ottavio P"'

1. Aspect ratio controls hot-carrier generation in gold nanobricks

Author

João, Simão M., Bassano, Ottavio, and Lischner, Johannes

Subjects
Physics - Optics, Condensed Matter - Materials Science
Abstract

Energetic or "hot" electrons and holes generated from the decay of localized surface plasmons in metallic nanoparticles have great potential for applications in photocatalysis, photovoltaics, and sensing. Here, we study the generation of hot carriers in brick-shaped gold nanoparticles using a recently developed modelling approach that combines a solution to Maxwell's equation with large-scale tight-binding simulations to evaluate Fermi's Golden Rule. We find that hot-carrier generation depends sensitively on the aspect ratio of the nanobricks with flatter bricks producing a large number of energetic electrons irrespective of the light polarization. In contrast, the hot-carrier generation rates of elongated nanobricks exhibits a strong dependence on the light polarization. The insights resulting from our calculations can be harnessed to design nanobricks that produce hot carriers with properties tailored to specific device applications.

Published
2024

5. Differences in life expectancy of adrenocortical carcinoma patients vs. age‑ and sex-matched population controls

Author

Jannello, Letizia Maria Ippolita, Baudo, Andrea, Scheipner, Lukas, de Angelis, Mario, Siech, Carolin, Di Bello, Francesco, Goyal, Jordan A., Vitucci, Kira, Tian, Zhe, Luzzago, Stefano, Mistretta, Francesco A., Ferro, Matteo, Saad, Fred, Chun, Felix K. H., Briganti, Alberto, Carmignani, Luca, Longo, Nicola, de Cobelli, Ottavio, Musi, Gennaro, and Karakiewicz, Pierre I.

Published
2025
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6. Characteristics of incidental prostate cancer in the United States

Author

Scheipner, Lukas, Incesu, Reha-Baris, Morra, Simone, Baudo, Andrea, Assad, Anis, Jannello, Letizia Maria Ippolita, Siech, Carolin, de Angelis, Mario, Barletta, Francesco, Tian, Zhe, Saad, Fred, Shariat, Shahrokh F., Briganti, Alberto, Chun, Felix K. H., Tilki, Derya, Longo, Nicola, Carmignani, Luca, De Cobelli, Ottavio, Ahyai, Sascha, and Karakiewicz, Pierre I.

Published
2024
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8. Urinary Diversion Versus Adverse In-Hospital Outcomes After Radical Cystectomy

Author

Rodriguez Peñaranda, Natali, di Bello, Francesco, Marmiroli, Andrea, Falkenbach, Fabian, Longoni, Mattia, Le, Quynh Chi, Goyal, Jordan A., Tian, Zhe, Saad, Fred, Shariat, Shahrokh F., Longo, Nicola, de Cobelli, Ottavio, Graefen, Markus, Briganti, Alberto, Chun, Felix K. H., Stella, Giuseppe, Piro, Adele, Puliatti, Stefano, Micali, Salvatore, and Karakiewicz, Pierre I.

Published
2025
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10. Adjuvant Systemic Therapy Improved Survival After Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma

Author

Di Bello, Francesco, Jannello, Letizia Maria Ippolita, Siech, Carolin, de Angelis, Mario, Rodriguez Peñaranda, Natali, Tian, Zhe, Goyal, Jordan A., Ruvolo, Claudia Collà, Califano, Gianluigi, Creta, Massimiliano, Morra, Simone, Saad, Fred, Shariat, Shahrokh F., de Cobelli, Ottavio, Briganti, Alberto, Chun, Felix K. H., Puliatti, Stefano, Longo, Nicola, and Karakiewicz, Pierre I.

Published
2024
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11. Can we predict pathology without surgery? Weighing the added value of multiparametric MRI and whole prostate radiomics in integrative machine learning models

Author

Marvaso, Giulia, Isaksson, Lars Johannes, Zaffaroni, Mattia, Vincini, Maria Giulia, Summers, Paul Eugene, Pepa, Matteo, Corrao, Giulia, Mazzola, Giovanni Carlo, Rotondi, Marco, Mastroleo, Federico, Raimondi, Sara, Alessi, Sarah, Pricolo, Paola, Luzzago, Stefano, Mistretta, Francesco Alessandro, Ferro, Matteo, Cattani, Federica, Ceci, Francesco, Musi, Gennaro, De Cobelli, Ottavio, Cremonesi, Marta, Gandini, Sara, La Torre, Davide, Orecchia, Roberto, Petralia, Giuseppe, and Jereczek-Fossa, Barbara Alicja

Published
2024
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12. Association between mpMRI detected tumor apparent diffusion coefficient and 5-year biochemical recurrence risk after radical prostatectomy

Author

Alessi, Sarah, Maggioni, Roberta, Luzzago, Stefano, Summers, Paul E., Renne, Giuseppe, Zugni, Fabio, Belmonte, Maddalena, Raimondi, Sara, Vignati, Silvano, Mistretta, Francesco A., Di Meglio, Letizia, D’Ascoli, Elisa, Scarabelli, Alice, Marvaso, Giulia, De Cobelli, Ottavio, Musi, Gennaro, Jereczek-Fossa, Barbara Alicja, Curigliano, Giuseppe, and Petralia, Giuseppe

Published
2024
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13. Radiotherapy Versus Partial Penectomy for T1 Squamous Cell Carcinoma of the Penis

Author

Jannello, Letizia Maria Ippolita, Siech, Carolin, de Angelis, Mario, Di Bello, Francesco, Rodriguez Peñaranda, Natali, Tian, Zhe, Goyal, Jordan A., Luzzago, Stefano, Mistretta, Francesco A., Montanari, Emanuele, Saad, Fred, Chun, Felix K. H., Briganti, Alberto, Micali, Salvatore, Longo, Nicola, de Cobelli, Ottavio, Musi, Gennaro, and Karakiewicz, Pierre I.

Published
2024
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15. Survival benefit of nephroureterectomy in systemic therapy exposed metastatic upper tract urinary urothelial carcinoma patients

Author

Morra, Simone, Incesu, Reha-Baris, Scheipner, Lukas, Baudo, Andrea, Jannello, Letizia Maria Ippolita, Siech, Carolin, de Angelis, Mario, Tian, Zhe, Creta, Massimiliano, Califano, Gianluigi, Collà Ruvolo, Claudia, Saad, Fred, Shariat, Shahrokh F., Chun, Felix K. H., de Cobelli, Ottavio, Musi, Gennaro, Briganti, Alberto, Tilki, Derya, Ahyai, Sascha, Carmignani, Luca, Longo, Nicola, and Karakiewicz, Pierre I.

Published
2024
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20. Cancer-specific mortality in non-metastatic T1a renal cell carcinoma treated with radiotherapy versus partial nephrectomy

Author

de Angelis, Mario, Morra, Simone, Scheipner, Lukas, Siech, Carolin, Jannello, Letizia Maria Ippolita, Baudo, Andrea, Goyal, Jordan A., Tian, Zhe, Longo, Nicola, Ahyai, Sascha, de Cobelli, Ottavio, Chun, Felix K. H., Saad, Fred, Shariat, Shahrokh F., Carmignani, Luca, Montorsi, Francesco, Briganti, Alberto, and Karakiewicz, Pierre I.

Published
2024
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21. Extreme-hypofractionated RT with concomitant boost to the DIL in PCa: a 5-year update on oncological and patient-reported outcomes for the phase II trial “GIVE ME FIVE”

Author

Marvaso, Giulia, Corrao, Giulia, Repetti, Ilaria, Lorubbio, Chiara, Bellerba, Federica, Zaffaroni, Mattia, Vincini, Maria Giulia, Zerini, Dario, Alessi, Sarah, Luzzago, Stefano, Mistretta, Francesco Alessandro, Fodor, Cristiana, Cambria, Raffaella, Cattani, Federica, Ceci, Francesco, Musi, Gennaro, De Cobelli, Ottavio, Zilli, Thomas, Gandini, Sara, Orecchia, Roberto, Petralia, Giuseppe, and Jereczek-Fossa, Barbara Alicja

Published
2024
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22. Towards Safer Robot-Assisted Surgery: A Markerless Augmented Reality Framework

Author

Chen, Ziyang, Cruciani, Laura, Fan, Ke, Fontana, Matteo, Lievore, Elena, De Cobelli, Ottavio, Musi, Gennaro, Ferrigno, Giancarlo, and De Momi, Elena

Subjects
Computer Science - Robotics
Abstract

Robot-assisted surgery is rapidly developing in the medical field, and the integration of augmented reality shows the potential of improving the surgeons' operation performance by providing more visual information. In this paper, we proposed a markerless augmented reality framework to enhance safety by avoiding intra-operative bleeding which is a high risk caused by the collision between the surgical instruments and the blood vessel. Advanced stereo reconstruction and segmentation networks are compared to find out the best combination to reconstruct the intra-operative blood vessel in the 3D space for the registration of the pre-operative model, and the minimum distance detection between the instruments and the blood vessel is implemented. A robot-assisted lymphadenectomy is simulated on the da Vinci Research Kit in a dry lab, and ten human subjects performed this operation to explore the usability of the proposed framework. The result shows that the augmented reality framework can help the users to avoid the dangerous collision between the instruments and the blood vessel while not introducing an extra load. It provides a flexible framework that integrates augmented reality into the medical robot platform to enhance safety during the operation.

Published
2023

23. The role of tumbling in bacterial scattering at convex obstacles

Author

Jakuszeit, Theresa and Croze, Ottavio A.

Subjects
Physics - Biological Physics, Condensed Matter - Soft Condensed Matter
Abstract

Active propulsion, as performed by bacteria and Janus particles, in combination with hydrodynamic interaction results in the accumulation of bacteria at a flat wall. However, in microfluidic devices with cylindrical pillars of sufficiently small radius, self-propelled particles can slide along and scatter off the surface of a pillar, without becoming trapped over long times. This non-equilibrium scattering process has been predicted to result in large diffusivities, even at high obstacle density, unlike particles that undergo classical specular reflection. Here, we test this prediction by experimentally studying the non-equilibrium scattering of pusher-like swimmers in microfluidic obstacle lattices. To explore the role of tumbles in the scattering process, we microscopically tracked wild-type (run and tumble) and smooth-swimming (run only) mutants of the bacterium Escherichia coli scattering off microfluidic pillars. We quantified key scattering parameters and related them to previously proposed models that included a prediction for the diffusivity, discussing their relevance. Finally, we discuss potential interpretations of the role of tumbles in the scattering process and connect our work to the broader study of swimmers in porous media., Comment: 9 pages, 8 figures

Published
2023
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25. Race/Ethnicity Affects Access and Survival Differences After Neoadjuvant or Adjuvant Chemotherapy at Radical Cystectomy in Urothelial Carcinoma Patients

Author

de Angelis, Mario, Jannello, Letizia Maria Ippolita, Siech, Carolin, Di Bello, Francesco, Peñaranda, Natali Rodriguez, Goyal, Jordan A., Tian, Zhe, Longo, Nicola, de Cobelli, Ottavio, Chun, Felix K. H., Puliatti, Stefano, Saad, Fred, Shariat, Shahrokh F., Gandaglia, Giorgio, Moschini, Marco, Montorsi, Francesco, Briganti, Alberto, and Karakiewicz, Pierre I.

Published
2024
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26. A COVID-19 specific multiparametric and ECG-based score for the prediction of in-hospital mortality: ELCOVID score

Author

Zuin, Marco, Ferrari, Roberto, Guardigli, Gabriele, Malagù, Michele, Vitali, Francesco, Zucchetti, Ottavio, D’Aniello, Emanuele, Di Ienno, Luca, Gibiino, Federico, Cimaglia, Paolo, Grosseto, Daniele, Corzani, Alessandro, Galvani, Marcello, Ortolani, Paolo, Rubboli, Andrea, Tortorici, Gianfranco, Casella, Gianni, Sassone, Biagio, Navazio, Alessandro, Rossi, Luca, Aschieri, Daniela, Mezzanotte, Roberto, Manfrini, Marco, and Bertini, Matteo

Published
2024
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27. Perioperative Complications and In-Hospital Mortality in Partial and Radical Nephrectomy Patients with Heart-Valve Replacement

Author

Siech, Carolin, Baudo, Andrea, de Angelis, Mario, Jannello, Letizia Maria Ippolita, Di Bello, Francesco, Goyal, Jordan A., Tian, Zhe, Saad, Fred, Shariat, Shahrokh F., Longo, Nicola, Carmignani, Luca, de Cobelli, Ottavio, Briganti, Alberto, Kosiba, Marina, Mandel, Philipp, Kluth, Luis A., Chun, Felix K. H., and Karakiewicz, Pierre I.

Published
2024
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31. Strain and sex-related behavioral variability of oxycodone dependence in rats

Author

Doyle, Michelle R, Martinez, Angelica R, Qiao, Ran, Dirik, Selen, Di Ottavio, Francesca, Pascasio, Glenn, Martin-Fardon, Rémi, Benner, Christopher, George, Olivier, Telese, Francesca, and de Guglielmo, Giordano

Subjects
Biological Psychology, Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Psychology, Prescription Drug Abuse, Substance Misuse, Brain Disorders, Behavioral and Social Science, Neurosciences, Opioid Misuse and Addiction, Pain Research, Drug Abuse (NIDA only), Chronic Pain, Opioids, Basic Behavioral and Social Science, Mental health, Good Health and Well Being, Rats, Female, Male, Animals, Oxycodone, Rats, Inbred ACI, Rats, Inbred F344, Rats, Inbred WKY, Analgesics, Opioid, Opioid-Related Disorders, Self Administration, Opioid use disorder, Rat, Self-administration, Sex, Strain, Neurology & Neurosurgery, Pharmacology and pharmaceutical sciences, Biological psychology
Abstract

Over the past two decades, the escalating prescription of opioid medications for pain management has culminated in a widespread opioid epidemic, significantly impacting public health, social dynamics, and economic stability. The urgent need for improved treatments for opioid addiction necessitates a deeper understanding of its biological underpinnings, with genetic variations playing a crucial role in individual susceptibility to opioid use disorder (OUD) and influencing clinical practices. In this study, we leverage the genetic diversity of four rat strains (ACI/N, BN/NHsd, WKY/N, and F344/N) to examine the contribution of genetic factors to oxycodone metabolism and addiction-like behaviors. We used the extended access to intravenous oxycodone self-administration procedure (12 h/day, 0.15 mg/kg/injection) to comprehensively characterize oxycodone-related behaviors and pharmacokinetics. We measured escalation of oxycodone self-administration, motivation for drug consumption, tolerance to the analgesic effects of oxycodone, withdrawal-induced hyperalgesia, and oxycodone-induced respiratory depression. Additionally, we examined oxycodone-seeking behavior after four weeks of withdrawal by reintroducing the animals to environmental and cue stimuli previously associated with oxycodone self-administration. The findings revealed notable strain differences in several behavioral measures, including oxycodone metabolism. Intriguingly, BN/NHsd and WKY/N strains exhibited similar drug intake and escalation patterns but displayed significant disparities in oxycodone and oxymorphone metabolism. Minimal sex differences were observed within strains, primarily relating to oxycodone metabolism. In conclusion, this study identifies strain differences in the behavioral responses and pharmacokinetics associated with oxycodone self-administration in rats, providing a robust foundation for identifying genetic and molecular variants associated with various facets of the opioid addiction process.

Published
2023

32. ASO Author Reflections: Urinary Diversion and Adverse in-Hospital Outcomes After Radical Cystectomy: Contemporary Versus Historical Cohorts

Author

Rodriguez Peñaranda, Natali, Di Bello, Francesco, Marmiroli, Andrea, Falkenbach, Fabian, Longoni, Mattia, Le, Quynh Chi, Goyal, Jordan A., Tian, Zhe, Saad, Fred, Shariat, Shahrokh F., Longo, Nicola, De Cobelli, Ottavio, Graefen, Markus, Briganti, Alberto, Chun, Felix K. H., Stella, Giuseppe, Piro, Adele, Puliatti, Stefano, Micali, Salvatore, and Karakiewicz, Pierre I.

Published
2025
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33. Semi-supervised Bladder Tissue Classification in Multi-Domain Endoscopic Images

Author

Lazo, Jorge F., Rosa, Benoit, Catellani, Michele, Fontana, Matteo, Mistretta, Francesco A., Musi, Gennaro, de Cobelli, Ottavio, de Mathelin, Michel, and De Momi, Elena

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning
Abstract

Objective: Accurate visual classification of bladder tissue during Trans-Urethral Resection of Bladder Tumor (TURBT) procedures is essential to improve early cancer diagnosis and treatment. During TURBT interventions, White Light Imaging (WLI) and Narrow Band Imaging (NBI) techniques are used for lesion detection. Each imaging technique provides diverse visual information that allows clinicians to identify and classify cancerous lesions. Computer vision methods that use both imaging techniques could improve endoscopic diagnosis. We address the challenge of tissue classification when annotations are available only in one domain, in our case WLI, and the endoscopic images correspond to an unpaired dataset, i.e. there is no exact equivalent for every image in both NBI and WLI domains. Method: We propose a semi-surprised Generative Adversarial Network (GAN)-based method composed of three main components: a teacher network trained on the labeled WLI data; a cycle-consistency GAN to perform unpaired image-to-image translation, and a multi-input student network. To ensure the quality of the synthetic images generated by the proposed GAN we perform a detailed quantitative, and qualitative analysis with the help of specialists. Conclusion: The overall average classification accuracy, precision, and recall obtained with the proposed method for tissue classification are 0.90, 0.88, and 0.89 respectively, while the same metrics obtained in the unlabeled domain (NBI) are 0.92, 0.64, and 0.94 respectively. The quality of the generated images is reliable enough to deceive specialists. Significance: This study shows the potential of using semi-supervised GAN-based bladder tissue classification when annotations are limited in multi-domain data. The dataset is available at https://zenodo.org/record/7741476#.ZBQUK7TMJ6k, Comment: Title and abstract updated. Typos corrected

Published
2022

34. Diffuse $\gamma$-ray emission in Cygnus X: Comments to Yan & Pavaskar

Author

Fornieri, Ottavio and Zhang, Heshou

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

It has been pointed out in arXiv:2211.17057 that our recent (published) paper might be revised, due to an incorrect evaluation of the diffusion coefficients, $D(E)$, employed in the calculations. Unfortunately, there is no indication as to where the incorrectness might be. Here we offer the opportunity to be more specific, by providing the community with the whole description of the equations involved in the calculation of $D(E)$, which is missing in the {\tt arXiv} note. In this context, we mention that no \textit{ad hoc} parameterisation has been used in our paper. Furthermore, any assumption on the injection mechanisms is explicitly described in the paper as an input factor and is obviously part of the modelisation procedure, hence the final outcome is subject to it. Finally, we discuss in a more broad context what, in this calculation of the diffusion coefficient, we believe is the key message., Comment: 4 pages, 1 figure

Published
2022

39. Evaluation of drivers of treatment switch in relapsing multiple sclerosis: a study from the Italian MS Registry

Author

Iaffaldano, Pietro, Lucisano, Giuseppe, Guerra, Tommaso, Patti, Francesco, Cocco, Eleonora, De Luca, Giovanna, Brescia Morra, Vincenzo, Pozzilli, Carlo, Zaffaroni, Mauro, Ferraro, Diana, Gasperini, Claudio, Salemi, Giuseppe, Bergamaschi, Roberto, Lus, Giacomo, Inglese, Matilde, Romano, Silvia, Bellantonio, Paolo, Di Monte, Elisabetta, Maniscalco, Giorgia Teresa, Conte, Antonella, Lugaresi, Alessandra, Vianello, Marika, Torri Clerici, Valentina Liliana Adriana, Di Sapio, Alessia, Pesci, Ilaria, Granella, Franco, Totaro, Rocco, Marfia, Girolama Alessandra, Danni, Maura Chiara, Cavalla, Paola, Valentino, Paola, Aguglia, Umberto, Montepietra, Sara, Ferraro, Elisabetta, Protti, Alessandra, Spitaleri, Daniele, Avolio, Carlo, De Riz, Milena, Maimone, Davide, Cavaletti, Guido, Gazzola, Paola, Tedeschi, Gioacchino, Sessa, Maria, Rovaris, Marco, Di Palma, Franco, Gatto, Maurizia, Cargnelutti, Daniela, De Robertis̄, Francesca, Logullo, Francesco Ottavio, Rini, Augusto, Meucci, Giuseppe, Ardito, Bonaventura, Banfi, Paola, Nasuelli, Davide, Paolicelli, Damiano, Rocca, Maria Assunta, Portaccio, Emilio, Chisari, Clara Grazia, Fenu, Giuseppe, Onofrj, Marco, Carotenuto, Antonio, Ruggieri, Serena, Tortorella, Carla, Ragonese, Paolo, Nica, Mihaela, Amato, Maria Pia, Filippi, Massimo, and Trojano, Maria

Published
2024
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41. ASO Author Reflections: Survival Benefit of Adjuvant Systemic Therapy After Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma

Author

Di Bello, Francesco, Jannello, Letizia Maria Ippolita, Siech, Carolin, de Angelis, Mario, Rodriguez Peñaranda, Natali, Tian, Zhe, Goyal, Jordan A., Ruvolo, Claudia Collà, Califano, Gianluigi, Creta, Massimiliano, Morra, Simone, Saad, Fred, Shariat, Shahrokh F., de Cobelli, Ottavio, Briganti, Alberto, Chun, Felix K. H., Puliatti, Stefano, Longo, Nicola, and Karakiewicz, Pierre I.

Published
2024
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42. MHD decomposition explains diffuse $\gamma$-ray emission in Cygnus X

Author

Fornieri, Ottavio and Zhang, Heshou

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Physics - Plasma Physics
Abstract

Cosmic-ray (CR) diffusion is the result of the interaction of such charged particles against magnetic fluctuations. These fluctuations originate from large-scale turbulence cascading towards smaller spatial scales, decomposed into three different modes, as described by $magneto-hydro-dynamics$ (MHD) theory. As a consequence, the description of particle diffusion strongly depends on the model describing the injected turbulence. Moreover, the amount of energy assigned to each of the three modes is in general not equally divided, which implies that diffusion properties might be different from one region to another. Here, motivated by the detection of different MHD modes inside the Cygnus-X star-forming region, we study the 3D transport of CRs injected by two prominent sources within a two-zone model that represents the distribution of the modes. Then, by convolving the propagated CR-distribution with the neutral gas, we are able to explain the $\gamma$-ray diffuse emission in the region, observed by the Fermi-LAT and HAWC Collaborations. Such a result represents an important step in the long-standing problem of connecting the CR observables with the micro-physics of particle transport., Comment: 7 pages, 4 figures

Published
2022
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43. Nature’s contribution to people provided by pastoral systems across European, African, and Middle East Mediterranean countries: trends, approaches and gaps

Author

Dean, Graeme, Francioni, Matteo, Toderi, Marco, López-i-Gelats, Feliu, Trozzo, Laura, Rivera-Ferre, Marta G., Franca, Antonello, Altana, Giovanni M., Karatassiou, Maria, Parissi, Zoi M., Abraham, Eleni M., Ragkos, Athanasios, Tolunay, Ahmet, Türkoğlu, Türkay, Tarhouni, Mohamed, Tlili, Abderrazak, Abbas, Khaled, Nori, Michele, Varela, Elsa, Lecegui, Antonio, Kyriazopoulos, Apostolos P., and D’Ottavio, Paride

Published
2024
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44. Enhancing untargeted metabolomics using metadata-based source annotation

Author

Gauglitz, Julia M, West, Kiana A, Bittremieux, Wout, Williams, Candace L, Weldon, Kelly C, Panitchpakdi, Morgan, Di Ottavio, Francesca, Aceves, Christine M, Brown, Elizabeth, Sikora, Nicole C, Jarmusch, Alan K, Martino, Cameron, Tripathi, Anupriya, Meehan, Michael J, Dorrestein, Kathleen, Shaffer, Justin P, Coras, Roxana, Vargas, Fernando, Goldasich, Lindsay DeRight, Schwartz, Tara, Bryant, MacKenzie, Humphrey, Gregory, Johnson, Abigail J, Spengler, Katharina, Belda-Ferre, Pedro, Diaz, Edgar, McDonald, Daniel, Zhu, Qiyun, Elijah, Emmanuel O, Wang, Mingxun, Marotz, Clarisse, Sprecher, Kate E, Vargas-Robles, Daniela, Withrow, Dana, Ackermann, Gail, Herrera, Lourdes, Bradford, Barry J, Marques, Lucas Maciel Mauriz, Amaral, Juliano Geraldo, Silva, Rodrigo Moreira, Veras, Flavio Protasio, Cunha, Thiago Mattar, Oliveira, Rene Donizeti Ribeiro, Louzada-Junior, Paulo, Mills, Robert H, Piotrowski, Paulina K, Servetas, Stephanie L, Da Silva, Sandra M, Jones, Christina M, Lin, Nancy J, Lippa, Katrice A, Jackson, Scott A, Daouk, Rima Kaddurah, Galasko, Douglas, Dulai, Parambir S, Kalashnikova, Tatyana I, Wittenberg, Curt, Terkeltaub, Robert, Doty, Megan M, Kim, Jae H, Rhee, Kyung E, Beauchamp-Walters, Julia, Wright, Kenneth P, Dominguez-Bello, Maria Gloria, Manary, Mark, Oliveira, Michelli F, Boland, Brigid S, Lopes, Norberto Peporine, Guma, Monica, Swafford, Austin D, Dutton, Rachel J, Knight, Rob, and Dorrestein, Pieter C

Subjects
Medical Biochemistry and Metabolomics, Analytical Chemistry, Biomedical and Clinical Sciences, Chemical Sciences, 2.1 Biological and endogenous factors, Humans, Tandem Mass Spectrometry, Metadata, Metabolomics
Abstract

Human untargeted metabolomics studies annotate only ~10% of molecular features. We introduce reference-data-driven analysis to match metabolomics tandem mass spectrometry (MS/MS) data against metadata-annotated source data as a pseudo-MS/MS reference library. Applying this approach to food source data, we show that it increases MS/MS spectral usage 5.1-fold over conventional structural MS/MS library matches and allows empirical assessment of dietary patterns from untargeted data.

Published
2022

46. Anisotropic diffusion cannot explain TeV halo observations

Author

Luque, Pedro De La Torre, Fornieri, Ottavio, and Linden, Tim

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies, High Energy Physics - Phenomenology
Abstract

TeV halos are regions of enhanced photon emissivity surrounding pulsars. While multiple sources have been discovered, a self-consistent explanation of their radial profile and spherically-symmetric morphology remains elusive due to the difficulty in confining high-energy electrons and positrons within ~20 pc regions of the interstellar medium. One proposed solution utilizes anisotropic diffusion to confine the electron population within a "tube" that is auspiciously oriented along the line of sight. In this work, we show that while such models may explain a unique source such as Geminga, the phase space of such solutions is very small and they are unable to simultaneously explain the size and approximate radial symmetry of the TeV halo population., Comment: 11 pages, 8 figures

Published
2022
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47. Galactic diffuse gamma rays meet the PeV frontier

Author

Luque, Pedro De la Torre, Gaggero, Daniele, Grasso, Dario, Fornieri, Ottavio, Egberts, Kathrin, Steppa, Constantin, and Evoli, Carmelo

Subjects
Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Phenomenology
Abstract

The Tibet AS$\gamma$ and LHAASO collaborations recently reported the observation of a $\gamma$-ray diffuse emission with energy up to the PeV from the Galactic plane. We discuss the relevance of non-uniform cosmic-ray transport scenarios and the implications of these results for cosmic-ray physics. We use the {\tt DRAGON} and {\tt HERMES} codes to build high-resolution maps and spectral distributions of that emission for several representative models under the condition that they reproduce a wide set of local cosmic-ray data up to 100 PeV. We show that the energy spectra measured by Tibet AS$\gamma$, LHAASO, ARGO-YBJ and Fermi-LAT in several regions of interest in the sky can all be consistently described in terms of the emission arising by the Galactic cosmic-ray "sea". We also show that all our models are compatible with IceTop $\gamma$-ray upper limits. Our results favor transport models characterized by spatial-dependent diffusion although some degeneracy remains between the choice of the transport scenario and that of the cosmic-ray spectral shape above 10 TeV. We discuss the role of forthcoming measurements in resolving that ambiguity., Comment: 10 pages, 9 figures, 1 table, material provided through https://github.com/tospines/Gamma-variable_High-resolution

Published
2022
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48. In-Hospital Venous Thromboembolism and Pulmonary Embolism After Major Urologic Cancer Surgery

Author

Cano Garcia, Cristina, Tappero, Stefano, Piccinelli, Mattia Luca, Barletta, Francesco, Incesu, Reha-Baris, Morra, Simone, Scheipner, Lukas, Baudo, Andrea, Tian, Zhe, Hoeh, Benedikt, Chierigo, Francesco, Sorce, Gabriele, Saad, Fred, Shariat, Shahrokh F., Carmignani, Luca, Ahyai, Sascha, Longo, Nicola, Tilki, Derya, Briganti, Alberto, De Cobell, Ottavio, Dell’Oglio, Paolo, Mandel, Philipp, Terrone, Carlo, Chun, Felix K. H., and Karakiewicz, Pierre I.

Published
2023
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49. Differences in future life expectancy of testicular germ-cell tumor patients vs. age-matched male population-based controls

Author

Morra, Simone, Piccinelli, Mattia Luca, Cano Garcia, Cristina, Tappero, Stefano, Barletta, Francesco, Incesu, Reha-Baris, Scheipner, Lukas, Baudo, Andrea, Tian, Zhe, Saad, Fred, Mirone, Vincenzo, Califano, Gianluigi, Colla’ Ruvolo, Claudia, Shariat, Shahrokh F., de Cobelli, Ottavio, Musi, Gennaro, Chun, Felix K. H., Terrone, Carlo, Briganti, Alberto, Tilki, Derya, Ahyai, Sascha, Carmignani, Luca, Longo, Nicola, and Karakiewicz, Pierre I.

Published
2023
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50. Making Good of a Pandemic: A Long-Distance Remedial Summer Course in Calculus

Author

Rizzo, Ottavio G.

Abstract

What do you do when a change in enrollment policies leaves you with more than 600 students in a first-term university calculus class, three-quarters of those students had a failing mark in mathematics in the pre-enrollment test, you planned a series of remedial activities for the second term, and the COVID-19 pandemic shuts the university down with a two-day notice? The pandemic hit instruction with might, forcing schools and universities that were timidly experimenting with digital tools to reinvent themselves in days. The pandemic also offered incentives for creative solutions that, in normal times, would have been considered fit for submission to the committee for recursive committee submissions at best. This paper narrates a teaching experience of how we proposed and managed an at-distance remedial course in August that not only catered to more than twice the number of students expected by our best forecasts, but was a very good success once its effectiveness was compared to the outcomes predicted by the pre-enrollment test scores. We expose the design of the course and link its measured effectiveness with both its design and student engagement; in particular, we show that a different approach to the examination of cognitive load and to fostering student-teacher and student-student communication thanks to digital mediation could be effective in countermanding the math-induced drop-out phenomenon in STEM.

Published
2021

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