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4. Dietary Habits and Risk of Esophagitis and Barrett’s Esophagus: A Multicenter Italian Case–Control Study

Author

Filiberti, Rosa Angela, primary, Fontana, Vincenzo, additional, De Ceglie, Antonella, additional, Blanchi, Sabrina, additional, Lacchin, Teresa, additional, De Matthaeis, Marina, additional, Ignomirelli, Orazio, additional, Cappiello, Roberta, additional, Rosa, Alessandra, additional, D’Onofrio, Vittorio, additional, Iaquinto, Gaetano, additional, and Conio, Massimo, additional

Published
2020
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6. Abincol® (Lactobacillus plantarum LP01, Lactobacillus lactis subspecies cremoris LLC02, Lactobacillus delbrueckii LDD01), an oral nutraceutical, pragmatic use in patients with chronic intestinal disorders

Author

Bonavina, Luigi, Arini, Andrea, Ficano, Leonardo, Iannuzziello, Donato, Pasquale, Luigi, Aragona, Salvo Emanuele, Ciprandi, Giorgio, Annicchiarico, Raffaele, Antongiulio, Bucci, Arrigoni, Arrigo, Bargiggia, Stefano, Beretta, Paolo, Berni Canani Marcella, Bertino, Antonino, Bova, Filippo, Bresci, Giampaolo, Buda, Carmelo, Camilleri, Salvatore, Caronna, Ste-fania, Cavallo, Gregorio, Chahin Nabil Jamil, Clara, Virgilio, Corrado, Selvaggio, Cozzoli, Giovanni, Crescenzi, Ugo, Dario, Raimondo, D’Arpa, Francesco, Dattola, Antonello, Deiana, Davide, Dell’Anna, Armando, Di Fenza Sergio, Di Lorenzo Fernando, Di Napoli An-gelo, D’Onofrio, Vittorio, Ferrini, Giovanni, Ferrulli, Domenico, Finizio, Roberto, Gaffuri, Nicola, Garcea Maria Rita, Genova, Salvatore, Giorgio, Pietro, Giovannone, Maurizio, Giuseppe, Giuliana, Guarnieri, Giovanni, Gullotta, Renzo, Leonardi, Giuseppe, Magrì, Giovanni, Maisto, Tammaro, Mancino, Mariagrazia, Manes, Gianpiero, Marchi, Santino, Marin, Renato, Marino, Maria, Mazzi, Manuele, Menasci, Francesca, Morabito Lo Prete Antonio, Murer, Francesca, Neri Bortoluzzi Francesco, Pallio, Socrate, Palma, Antonio, Pardocchi, Da-vide, Pinto, Antonio, Pio Palieri Antonio, Pisani, Antonio, Privitera, Antonello, Pulitanò, Raffaela, Pumpo, Rossella, Quatraro, Francesco, Raguzzi, Ivana, Rainisio, Cesarina, Razzolini, Giulia, Revello, Olimpia, Rinaldo, Nicita, Rivellini, Giuseppe, Sabadini, Guidorenato, Salvia, Marcello, Sarrantonio, Gennaro, Savarino, Edoardo, Scarcelli, Antonella, Schettino, Pietro, Schicchi, Angelo, Schiffino, Luigi, Sediari, Luca, Shaini, Endrit, Spada, Cristiano, Spinelli, Fernando, Tifi, Lorenza, Trovato, Claudio, Vassallo, Roberto, Vinti, Maurizio, Zappatore, Francesca, and Zulli, Claudio.

Subjects
Diverticular Diseases, Male, irritable bowel syndrome, Lactobacillus delbrueckii, Probiotics, diverticular disease, Administration, Oral, Inflammatory bowel disease, irritable bowel syndrome, diverticular disease, probiotic, survey, Middle Aged, Inflammatory Bowel Diseases, Lactobacillus, inflammatory bowel disease, Chronic Disease, Dietary Supplements, Humans, Female, Original Article, survey, Self Report, probiotic, Lactobacillus plantarum
Abstract

Chronic intestinal disorders (CID), including inflammatory bowel disease (IBD), such as ulcerative colitis and Crohn’s disease, irritable bowel syndrome (IBS), and diverticular disease (DD), are diseases that relapse episodes. There is evidence that patients with CID have intestinal dysbiosis, so probiotics may counterbalance the impaired microbiota. Therefore, the current survey evaluated the efficacy and safety of Abincol®,an oral nutraceuticalcontaining a probiotic mixture with Lactobacillus plantarum LP01 (1 billion of living cells), Lactobacillus lactis subspecies cremoris LLC02 (800 millions of living cells), and Lactobacillus delbrueckii LDD01 (200 millions of living cells), in 3,460 outpatients (1,660 males and 1,800 females, mean age 55 years) with chronic intestinal disorders. Patients took 1 stick/daily for 8 weeks. Abincol® significantly diminished the presence and the severity of intestinal symptoms and improved stool form. In conclusion, the current survey suggests that Abincol® may be considered an effective and safe therapeutic option in the management of patients with chronic intestinal disorders. (www.actabiomedica.it)

Published
2019

7. Post-surgical intestinal dysbiosis: use of an innovative mixture (Lactobacillus plantarum LP01, Lactobacillus lactis subspecies cremoris LLC02, Lactobacillus delbrueckii LDD01)

Author

Bonavina, Luigi, Arini, Andrea, Ficano, Leonerdo, Iannuzziello, Donato, Pasquale, Luigi, Aragona, Salvo Emanuele, Ciprandi, Giorgio, Annicchiarico, Raffaele, Antongiulio, Bucci, Arrigoni, Arrigo, Bargiggia, Stefano, Beretta, Paolo, Berni Canani Marcella, Bertino, Antonino, Bova, Filippo, Bresci, Giampaolo, Buda, Carmelo, Camilleri, Salvatore, Caronna, Ste-fania, Cavallo, Gregorio, Chahin Nabil Jamil, Clara, Virgilio, Corrado, Selvaggio, Cozzoli, Giovanni, Crescenzi, Ugo, Dario, Raimondo, D’Arpa, Francesco, Dattola, Antonello, Deiana, Davide, Dell’Anna, Armando, Di Fenza Sergio, Di Lorenzo Fernando, Di Napoli An-gelo, D’Onofrio, Vittorio, Ferrini, Giovanni, Ferrulli, Domenico, Finizio, Roberto, Gaffuri, Nicola, Garcea Maria Rita, Genova, Salvatore, Giorgio, Pietro, Giovannone, Maurizio, Giuseppe, Giuliana, Guarnieri, Giovanni, Gullotta, Renzo, Leonardi, Giuseppe, Magrì, Giovanni, Maisto, Tammaro, Mancino, Mariagrazia, Manes, Gianpiero, Marchi, Santino, Marin, Renato, Marino, Maria, Mazzi, Manuele, Menasci, Francesca, Morabito Lo Prete Antonio, Murer, Francesca, Neri Bortoluzzi Francesco, Pallio, Socrate, Palma, Antonio, Pardocchi, Da-vide, Pinto, Antonio, Pio Palieri Antonio, Pisani, Antonio, Privitera, Antonello, Pulitanò, Raffaela, Pumpo, Rossella, Quatraro, Francesco, Raguzzi, Ivana, Rainisio, Cesarina, Razzolini, Giulia, Revello, Olimpia, Rinaldo, Nicita, Rivellini, Giuseppe, Sabadini, Guidorenato, Salvia, Marcello, Sarrantonio, Gennaro, Savarino, Edoardo, Scarcelli, Antonella, Schettino, Pietro, Schicchi, Angelo, Schiffino, Luigi, Sediari, Luca, Shaini, Endrit, Spada, Cristiano, Spinelli, Fernando, Tifi, Lorenza, Trovato, Claudio, Vassallo, Roberto, Vinti, Maurizio, Zappatore, Francesca, and Zulli, Claudio.

Subjects
Male, Lactobacillus delbrueckii, Probiotics, Digestive surgery, dysbiosis, microbiota, probiotic, survey, dysbiosis, Middle Aged, Gastrointestinal Microbiome, Lactobacillus, Postoperative Complications, Treatment Outcome, Abdomen, microbiota, Humans, digestive surgery, Female, Original Article, survey, probiotic, Lactobacillus plantarum
Abstract

Abdominal surgery represents a high risk for hospital-acquired infections and complication that may compromise the surgery outcome. Patients with recent abdominal surgery have an intestinal dysbiosis. There is evidence that probiotics may counterbalance the impaired microbiota. Therefore, the current survey evaluated the efficacy and safety of Abincol®,an oral nutraceuticalcontaining a probiotic mixture with Lactobacillus plantarum LP01 (1 billion of living cells), Lactobacillus lactis subspecies cremoris LLC02 (800 millions of living cells), and Lactobacillus delbrueckii LDD01 (200 millions of living cells), in 612 outpatients (344 males and 268 females, mean age 58 years) undergoing digestive surgery. Patients took 1 stick/daily for 8 weeks. Abincol® significantly diminished the presence and the severity of intestinal symptoms and improved stool form. In conclusion, the current survey suggests that Abincol® may be considered an effective and safe therapeutic option in the management of patients undergoing digestivesurgery. (www.actabiomedica.it)

Published
2019

8. Lactobacillus plantarum LP01, Lactobacillus lactis subspecies cremoris LLC02, and Lactobacillus delbrueckii LDD01) in patients undergoing bowel preparation

Author

Bonavina, L., Ariani, A., Ficano, L., Iannuzziello, D., Pasquale, L., Aragona, S. E., Drago, L., Ciprandi, G., Annicchiarico Raffaele, On Digestive Disorders I. S. G., Antongiulio, Bucci, Arrigoni, Arrigo, Bargiggia, Stefano, Beretta, Paolo, Berni Canani Marcella, Bertino, Antonino, Bova, Filippo, Bresci, Giampaolo, Buda, Carmelo, Camilleri, Salvatore, Caronna, Ste-fania, Cavallo, Gregorio, Chahin Nabil Jamil, Clara, Virgilio, Corrado, Selvaggio, Cozzoli, Giovanni, Crescenzi, Ugo, Dario, Raimondo, D’Arpa, Francesco, Dattola, Antonello, Deiana, Davide, Dell’Anna, Armando, Di Fenza Sergio, Di Lorenzo Fernando, Di Napoli An-gelo, D’Onofrio, Vittorio, Ferrini, Giovanni, Ferrulli, Domenico, Finizio, Roberto, Gaffuri, Nicola, Garcea Maria Rita, Genova, Salvatore, Giorgio, Pietro, Giovannone, Maurizio, Giuseppe, Giuliana, Guarnieri, Giovanni, Gullotta, Renzo, Leonardi, Giuseppe, Magrì, Giovanni, Maisto, Tammaro, Mancino, Mariagrazia, Manes, Gianpiero, Marchi, Santino, Marin, Renato, Marino, Maria, Mazzi, Manuele, Menasci, Francesca, Morabito Lo Prete Antonio, Murer, Francesca, Neri Bortoluzzi Francesco, Pallio, Socrate, Palma, Antonio, Pardocchi, Da-vide, Pinto, Antonio, Pio Palieri Antonio, Pisani, Antonio, Privitera, Antonello, Pulitanò, Raffaela, Pumpo, Rossella, Quatraro, Francesco, Raguzzi, Ivana, Rainisio, Cesarina, Razzolini, Giulia, Revello, Olimpia, Rinaldo, Nicita, Rivellini, Giuseppe, Sabadini, Guidorenato, Salvia, Marcello, Sarrantonio, Gennaro, Savarino, Edoardo, Scarcelli, Antonella, Schettino, Pietro, Schicchi, Angelo, Schiffino, Luigi, Sediari, Luca, Shaini, Endrit, Spada, Cristiano, Spinelli, Fernando, Tifi, Lorenza, Trovato, Claudio, Vassallo, Roberto, Vinti, Maurizio, Zappatore, Francesca, and Zulli, Claudio.

Subjects
Male, Lactobacillus delbrueckii, gut microbiota, Probiotics, Colonoscopy, Middle Aged, Lactobacillus, Preoperative Care, bowel preparation, Dysbiosis, Humans, Female, Original Article, survey, bowel preparation, gut microbiota, colonoscopy, probiotics, survey, Lactobacillus plantarum
Abstract

Bowel preparation (BP) for colonoscopy induces significantly changes in gut microbiota and elicit intestinal symptoms. Impaired microbiota causes an intestinal dysbiosis. Consequently, probiotics may counterbalance the disturbed microbiota after BP. The current survey evaluated the efficacy and safety of Abincol®,an oral nutraceuticalcontaining a probiotic mixture with Lactobacillus plantarum LP01 (1 billion of living cells), Lactobacillus lactis subspecies cremoris LLC02 (800 millions of living cells), and Lactobacillus delbrueckii LDD01 (200 millions of living cells), in 2,979 outpatients (1,579 males and 1,400 females, mean age 56 years) undergoing BP. Patients took 1 stick/daily for 4 weeks after colonoscopy. Abincol® significantly diminished the presence and the severity of intestinal symptoms and improved stool form. In conclusion, the current survey suggests that Abincol® may be considered an effective and safe therapeutic option in the management of patients undergoing BP. (www.actabiomedica.it)

Published
2019

9. Long-term endoscopic surveillance of patients with Barrett's esophagus. incidence of dysplasia and adenocarcinoma: a prospective study

Author

Conio, Massimo, Blanchi, Sabrina, Lapertosa, Gabriella, Ferraris, Roberto, Sablich, Renato, Marchi, Santino, D'Onofrio, Vittorio, Lacchin, Teresa, Iaquinto, Gaetano, Missale, Guido, Ravelli, Paolo, Cestari, Renzo, Benedetti, Giorgio, Macrì, Giuseppe, Fiocca, Roberto, Munizzi, Francesco, and Filiberti, Rosangela

Published
2003
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11. Bloating is associated with worse quality of life, treatment satisfaction, and treatment responsiveness among patients with constipation-predominant irritable bowel syndrome and functional constipation

Author

Neri, L., Iovino, P., Altomare, Donato Francesco, Annese, Vito, Badiali, Danilo, Basilisco, Guido, Bassotti, Gabrio, Battaglia, Edda, Bazzocchi, Gabriele, Bellini, Massimo, Bendia, Emanuele, Benini, Luigi, Biscaglia, Giuseppe, Biviano, Ivano, Bocchini, Renato, Bonventre, Sebastiano, Bossa, Fabrizio, Brandimarte, Giovanni, Cannizzaro, Renato, Cicala, Michele, Cipolletta, Livio, Clara, Virgilio, Cogliandro, Rosanna, Comandini, Giulia, Corazziari, Enrico, Crotta, Sergio, Cuomo, Rosario, D'Alba, Lucia, De Giorgi, Francesco, Del Piano, Mario, Di Fonzo, Michela, Di Mario, Francesco, Di Stefano, Michele, D'Onofrio, Vittorio, Efthymakis, Kostantinos, Fiore, Pierluigi, Fortuna, Manuela, Fries, Walter, Gaetani, Eleonora, Galeazzi, Francesca, Gasbarrini, Antonio, Geccherle, Andrea, Giangregorio, Francesco, Girardi, Lisa, Grassini, Mario, Groppo, Marzia, Guarnieri, Giovanni, Lo Cascio, Massimiliano, Lolli, Roberto, Luzza, Francesco, Macarri, Giampiero, Marino, Maria, Miraglia, Stefania, Monastra, Santo, Neri, Maria Cristina, Neri, Matteo, Noris, Roberto Antonio, Orselli, Silvia, Passaretti, Sandro, Paviotti, Alberto, Pazzi, Paolo, Pilotto, Alberto, Portincasa, Piero, Ranaldo, Nunzio, Ravelli, Paolo, Rogai, Francesca, Sablich, Renato, Savarino, Vincenzo, Spinzi, Giancarlo, Stanghellini, Vincenzo, Tammaro, Leonardo, Torresan, Francesco, Usai Satta, Paolo, Valle, C. Claudio, Neri, L., Iovino, P., Altomare, Donato Francesco, Annese, Vito, Badiali, Danilo, Basilisco, Guido, Bassotti, Gabrio, Battaglia, Edda, Bazzocchi, Gabriele, Bellini, Massimo, Bendia, Emanuele, Benini, Luigi, Biscaglia, Giuseppe, Biviano, Ivano, Bocchini, Renato, Bonventre, Sebastiano, Bossa, Fabrizio, Brandimarte, Giovanni, Cannizzaro, Renato, Cicala, Michele, Cipolletta, Livio, Clara, Virgilio, Cogliandro, Rosanna, Comandini, Giulia, Corazziari, Enrico, Crotta, Sergio, Cuomo, Rosario, D'Alba, Lucia, De Giorgi, Francesco, Del Piano, Mario, Di Fonzo, Michela, Di Mario, Francesco, Di Stefano, Michele, D'Onofrio, Vittorio, Efthymakis, Kostantino, Fiore, Pierluigi, Fortuna, Manuela, Fries, Walter, Gaetani, Eleonora, Galeazzi, Francesca, Gasbarrini, Antonio, Geccherle, Andrea, Giangregorio, Francesco, Girardi, Lisa, Grassini, Mario, Groppo, Marzia, Guarnieri, Giovanni, Lo Cascio, Massimiliano, Lolli, Roberto, Luzza, Francesco, Macarri, Giampiero, Marino, Maria, Miraglia, Stefania, Monastra, Santo, Neri, Maria Cristina, Neri, Matteo, Noris, Roberto Antonio, Orselli, Silvia, Passaretti, Sandro, Paviotti, Alberto, Pazzi, Paolo, Pilotto, Alberto, Portincasa, Piero, Ranaldo, Nunzio, Ravelli, Paolo, Rogai, Francesca, Sablich, Renato, Savarino, Vincenzo, Spinzi, Giancarlo, Stanghellini, Vincenzo, Tammaro, Leonardo, Torresan, Francesco, Usai Satta, Paolo, Valle, C. Claudio, Altomare, D., Annese, V., Badiali, D., Basilisco, G., Bassotti, G., Battaglia, E., Bazzocchi, G., Bellini, M., Bendia, E., Benini, L., Biscaglia, G., Biviano, I., Bocchini, R., Bonventre, S., Bossa, F., Brandimarte, G., Cannizzaro, R., Cicala, M., Cipolletta, L., Clara, V., Cogliandro, R., Comandini, G., Corazziari, E., Crotta, S., Cuomo, R., D'Alba, L., De Giorgi, F., Del Piano, M., Di Fonzo, M., Di Mario, F., Di Stefano, M., D'Onofrio, V., Efthymakis, K., Fiore, P., Fortuna, M., Fries, W., Gaetani, E., Galeazzi, F., Gasbarrini, A., Geccherle, A., Giangregorio, F., Girardi, L., Grassini, M., Groppo, M., Guarnieri, G., Lo Cascio, M., Lolli, R., Luzza, F., Macarri, G., Marino, M., Miraglia, S., Monastra, S., Neri, M., Noris, R., Orselli, S., Passaretti, S., Paviotti, A., Pazzi, P., Pilotto, A., Portincasa, P., Ranaldo, N., Ravelli, P., Rogai, F., Sablich, R., Savarino, V., Spinzi, G., Stanghellini, V., Tammaro, L., Torresan, F., Usai Satta, P., and Valle, C.

Subjects
Adult, Male, Quality of life, medicine.medical_specialty, Constipation, Cross-sectional study, Physiology, Bloating, Chronic constipation, Functional constipation, Irritable bowel syndrome, Patient-reported outcomes, Treatment satisfaction, Endocrine and Autonomic Systems, Gastroenterology, Cross-Sectional Studies, Female, Flatulence, Humans, Irritable Bowel Syndrome, Middle Aged, Prevalence, Quality of Life, Surveys and Questionnaires, Endocrine and Autonomic System, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Patient-reported outcome, Settore MED/12 - Gastroenterologia, business.industry, Settore MED/09 - MEDICINA INTERNA, medicine.disease, Settore MED/18 - Chirurgia Generale, Tolerability, 030220 oncology & carcinogenesis, Physical therapy, 030211 gastroenterology & hepatology, medicine.symptom, business
Abstract

Background The management of bloating is unclear and its relationship with patients' well-being and treatment satisfaction independent of other abdominal symptoms is uncharacterized. We evaluated the association of bloating with patient-reported outcomes. Methods Thirty-nine centers for functional gastrointestinal disorders joined the laxative inadequate relief survey. We enrolled 2203 consecutive outpatients with functional constipation (FC) or constipation-predominant irritable bowel syndrome (IBS-C) in two cross-sectional waves. Both wave 1 and 2 included the SF-12, the patient assessment of constipation-symptoms (PAC-SYM), and the treatment satisfaction questionnaire for medication (TSQM-2). Wave 2 only included a global rating of change (GRC) scale to assess patients' assessment of efficacy concerning treatment switches occurred in the 3 months prior to the interview. Bloating in the abdomen was defined on the basis of PAC-SYM item 3. Key Results The average age was 50.1 years (SD, 16.7) and 82.1% of patients were women. The prevalence of bloating was 91.6% (n = 1970). Bloating was associated with SF-12 Physical Composite Score (p < 0.01), SF-12 Mental Composite Score (p < 0.01), GRC (p < 0.01), Satisfaction with treatment effectiveness (p < 0.01), convenience of administration (p < 0.01), and side effects (p < 0.01) after adjustment for possible confounders. Conclusions & Inferences Our data suggest that patients regard bloating as a key element in assessing clinical changes and treatments' efficacy as this symptom exerts a strong influence on patient-reported outcomes independent of possible confounders and other symptoms of constipation. Our data provide the rationale to investigate the efficacy and tolerability of new treatments specifically addressing this important, yet disregarded, patients' complain.

Published
2016

12. Alcohol consumption pattern and risk of Barrett’s oesophagus and erosive oesophagitis: an Italian case–control study

Author

Filiberti, Rosa A., primary, Fontana, Vincenzo, additional, De Ceglie, Antonella, additional, Blanchi, Sabrina, additional, Grossi, Enzo, additional, Della Casa, Domenico, additional, Lacchin, Teresa, additional, De Matthaeis, Marina, additional, Ignomirelli, Orazio, additional, Cappiello, Roberta, additional, Rosa, Alessandra, additional, Foti, Monica, additional, Laterza, Francesco, additional, D’Onofrio, Vittorio, additional, Iaquinto, Gaetano, additional, and Conio, Massimo, additional

Published
2017
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13. Early precut sphincterotomy for difficult biliary access to reduce post-ERCP pancreatitis: a randomized trial

Author

Mariani, Alberto, additional, Di Leo, Milena, additional, Giardullo, Nicola, additional, Giussani, Antonella, additional, Marini, Mario, additional, Buffoli, Federico, additional, Cipolletta, Livio, additional, Radaelli, Franco, additional, Ravelli, Paolo, additional, Lombardi, Giovanni, additional, D’Onofrio, Vittorio, additional, Macchiarelli, Raffaele, additional, Iiritano, Elena, additional, Le Grazie, Marco, additional, Pantaleo, Giuseppe, additional, and Testoni, Pier, additional

Published
2016
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16. Randomized Controlled Trial of Botulinum Toxin Versus Laparoscopic Heller Myotomy for Esophageal Achalasia

Author

Zaninotto, Giovanni, primary, Annese, Vito, additional, Costantini, Mario, additional, Del Genio, Alberto, additional, Costantino, Michela, additional, Epifani, Magdalena, additional, Gatto, Giovanni, additional, D'onofrio, Vittorio, additional, Benini, Luigi, additional, Contini, Sandro, additional, Molena, Daniela, additional, Battaglia, Giorgio, additional, Tardio, Berardino, additional, Andriulli, Angelo, additional, and Ancona, Ermanno, additional

Published
2004
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20. Effect of ethanol on serum histamine levels in humans

Author

Iaquinto, Gaetano, primary, Taccone, Walter, additional, Giardullo, Nicola, additional, D’Onofrio, Vittorio, additional, Cristina Parodi, Maria, additional, Pasquale, Luigi, additional, Sorrentini, Italo, additional, and Szabo, Sandor, additional

Published
2000
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23. Long-Term Effectiveness and Safety of Ustekinumab in Crohn's Disease: Results from a Large Real-Life Cohort Study.

Author

Mocci G, Tursi A, Scaldaferri F, Napolitano D, Pugliese D, Capobianco I, Bartocci B, Blasi V, Savarino EV, Maniero D, Redavid C, Lorenzon G, Cuomo A, Donnarumma L, Gravina AG, Pellegrino R, Bodini G, Pasta A, Marzo M, Serio M, Scarcelli A, Rodinò S, Sebkova L, Maconi G, Cataletti G, Luppino I, Checchin D, Ferronato A, Gaiani F, Kayali S, Felice C, Pranzo G, Catarella D, D'Agostino D, Di Bartolo E, Lombardi G, Patturelli M, Bendia E, Bolognini L, Balducci D, Quatraccioni C, Martini F, Mucherino C, D'Antonio E, Montesano L, Vespere G, Sedda S, D'Onofrio V, De Luca L, Spagnuolo R, Luzza F, Fanigliulo L, Rocco G, Sacchi C, Zampaletta C, Grossi L, Lorenzetti R, Aragona G, Perazzo P, Forti G, Allegretta L, Cazzato AI, Scorza S, Cortellini F, Capone P, Villani GD, Di Fonzo M, Iacopini F, Tonti P, Neve V, Colucci R, Elisei W, Monterubbianesi R, Faggiani R, Pica R, Pagnini C, Graziani MG, Di Paolo MC, Onidi FM, Saba F, Dore MP, Satta PU, Picchio M, and Papa A

Abstract

Background: Ustekinumab (UST) is an interleukin-12/interleukin-23 receptor antagonist approved for the treatment of Crohn's disease (CD). Only limited real-life data on the long-term outcomes of CD patients treated with UST are available. This study assessed UST's long-term effectiveness and safety in a large population-based cohort of moderate to severe CD patients. Methods: This was a multicenter, retrospective, observational cohort study that included both naïve and biologic-experienced patients treated with UST who achieved clinical remission or clinical response after at least one year of treatment. Clinical activity was scored according to the Harvey-Bradshaw Index (HBI). The primary endpoints were the maintenance or achievement of clinical remission after a further 12-month period of treatment, defined as an HBI of ≤5, and safety. Other endpoints included steroid-free remission, mucosal healing (MH), steroid discontinuation, and the need for treatment optimization during the follow-up. Results: Out of 562 CD patients, after an overall 24-month follow-up, clinical remission was present in 450 (80.0%) patients, and at 12 months, clinical remission was observed in 417/437 (95.4%) patients; 33/125 (26.4%) showed clinical response at 12 months ( p = 0.000). A total of 38/103 (36.9%) patients achieved MH. Only 2.1% (12/562), 3% (17/562), and 1.1% (6/562) of patients required surgery, optimization, and re-induction, respectively. Adverse events occurred in eight patients (1.42%). According to a multivariate analysis, the only predictor of long-term remission was the presence of remission at the 12-month follow-up ( p = 0.000). Conclusions : Long-term treatment with UST presents good efficacy and safety profiles in CD patients, especially for patients who achieve remission after one year.

Published
2024
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24. Coexpression of Helicobacter pylori's proteins CagA and HspB induces cell proliferation in AGS gastric epithelial cells, independently from the bacterial infection.

Author

De Luca A, Baldi A, Russo P, Todisco A, Altucci L, Giardullo N, Pasquale L, Iaquinto S, D'Onofrio V, Parodi MC, Paggi MG, and Iaquinto G

Subjects
Antigens, Bacterial biosynthesis, Antigens, Bacterial genetics, Bacterial Proteins biosynthesis, Bacterial Proteins genetics, Cell Cycle physiology, Cell Division physiology, Cells, Cultured, Epithelial Cells cytology, Epithelial Cells metabolism, Epithelial Cells physiology, Gastric Mucosa physiology, Heat-Shock Proteins biosynthesis, Heat-Shock Proteins genetics, Helicobacter Infections metabolism, Helicobacter Infections pathology, Humans, Transfection, Antigens, Bacterial physiology, Bacterial Proteins physiology, Gastric Mucosa cytology, Gastric Mucosa metabolism, Heat-Shock Proteins physiology, Helicobacter pylori metabolism
Abstract

Adenocarcinoma of the stomach is the second most common cause of cancer mortality in the world. The purpose of this study was to evaluate the potential role in carcinogenesis of two secreted Helicobacter pylori's proteins, CagA and HspB, both shown to increase the risk of gastric carcinoma in patients infected with H. pylori-positive strain. The effects of these two proteins on cell kinetics and the ability to selectively affect the expression of cell cycle-related proteins by transfection of a human gastric epithelial cell line (AGS) were analyzed. Using a genomic library of H. pylori, we isolated and cloned CagA and HspB. The effects of the overexpression of these proteins on cell growth were analyzed in AGS cells by immunoblots, proliferation assay, and flow cytometry. Coexpression of CagA and HspB in AGS cells in the first 48 h caused an increase of the level of E2F transcription factor, cyclin D3, and phosphorylated retinoblastoma protein, all involved in the G(1)-S checkpoint of the cell cycle. Consistently, an increase of cell proliferation, corresponding to an augment of the fraction of the cells in the S-G(2)-M phase of the cell cycle, was also demonstrated. Moreover, an increase of c-jun protein levels, but not of c-fos, was also found after coexpression of CagA and HspB. All these data suggest that CagA and HspB, independently from the bacterial infection, have a direct effect on the cell growth of the gastric cells acting on the G(1)-S checkpoint of the cell cycle.

Published
2003

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