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1. Risk factors for progression in patients with KDOQI stage 3 Chronic Kidney Disease (PROGRESER study)

Author

Martínez-Castelao, Alberto, Górriz Teruel, José Luis, D’Marco, Luis, Garrigós, Enrique, Fernández-Fresnedo, Gema, Espinel Garuz, Eugenia, Cigarrán Guldris, Secundino, Coloma, Jesús Arteaga, Robles Pérez-Monteoliva, Nicolas Roberto, Esteban de la Rosa, José Rafael, Nieto Iglesias, Luis Javier, Ortiz Arduán, Alberto, and Navarro-González, Juan Francisco

Published
2024
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4. Silver jubilee: 25 years of the first demonstration of the direct effect of phosphate on the parathyroid cell

Author

Bover, Jordi, Trinidad, Pedro, Jara, Aquiles, Soler-Majoral, Jordi, Martín-Malo, Alejandro, Torres, Armando, Frazão, João, Ureña, Pablo, Dusso, Adriana, Arana, Carolt, Graterol, Fredzzia, Romero-González, Gregorio, Troya, Maribel, Samaniego, Diana, D’Marco, Luis, Valdivielso, José Manuel, Fernández, Elvira, Arenas, María Dolores, Torregrosa, Vicente, Navarro-González, Juan F., Lloret, María Jesús, Ballarín, J.A., Bosch, Ricardo J, Górriz, José L., de Francisco, AGL, Gutiérrez, Orlando, Ara, Jordi, Felsenfeld, Arnold, Canalejo, Antonio, and Almadén, Yolanda

Published
2022
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5. Bodas de plata: 25 años de la primera demostración del efecto directo del fósforo en la célula paratiroidea

Author

Bover, Jordi, Trinidad, Pedro, Jara, Aquiles, Soler-Majoral, Jordi, Martín-Malo, Alejandro, Torres, Armando, Frazão, João, Ureña, Pablo, Dusso, Adriana, Arana, Carolt, Graterol, Fredzzia, Romero, Gregorio, Troya, Maribel, Samaniego, Diana, D’Marco, Luis, Valdivielso, José Manuel, Fernández, Elvira, Arenas, María Dolores, Torregrosa, Vicente, Navarro-González, Juan F., Lloret, María Jesús, Ballarín, J.A., Bosch, Ricardo J., Górriz, José L., de Francisco, Angel Luis Martin, Gutiérrez, Orlando, Ara, Jordi, Felsenfeld, Arnold, Canalejo, Antonio, and Almadén, Yolanda

Published
2022
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13. Albuminuria-Lowering Effect of Dapagliflozin, Eplerenone, and Their Combination in Patients with Chronic Kidney Disease: A Randomized Crossover Clinical Trial

Author

Provenzano, Michele, Puchades, Maria Jesús, Garofalo, Carlo, Jongs, Niels, D’Marco, Luis, Andreucci, Michele, De Nicola, Luca, Gorriz, Jose Luis, Heerspink, Hiddo J.L., Pennino, Luigi, De Gregorio, Ilaria, Polese, Lucio, Caturano, Alfredo, Minutolo, Roberto, Sasso, Ferdinando, Gagliardi, Ida, Zicarelli, Mariateresa, Crugliano, Giuseppina, Civera, Elena Gimenez, Panizo, Nayara, Sen, Taha, and Xie, Di

Published
2022
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17. Glomerular and tubular effects of dapagliflozin, eplerenone and their combination in patients with chronic kidney disease: A post‐hoc analysis of the ROTATE‐3 study

Author

Lieverse, Tom T. G. F., primary, Puchades, Maria J., additional, Mulder, Udo D. J., additional, Provenzano, Michele, additional, Krenning, Guido, additional, Jongs, Niels, additional, Wink, Simon E., additional, Slart, Riemer H. J. A., additional, Andreucci, Michele, additional, D'Marco, Luis, additional, De Nicola, Luca, additional, Gorriz, Jose L., additional, and Heerspink, Hiddo J. L., additional

Published
2023
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19. The Role of Specialized Pro-Resolving Lipid Mediators in Inflammation-Induced Carcinogenesis

Author

Torres, Wheeler, primary, Pérez, José Luis, additional, Díaz, María P., additional, D’Marco, Luis, additional, Checa-Ros, Ana, additional, Carrasquero, Rubén, additional, Angarita, Lissé, additional, Gómez, Yosselin, additional, Chacín, Maricarmen, additional, Ramírez, Paola, additional, Villasmil, Nelson, additional, Durán-Agüero, Samuel, additional, Cano, Clímaco, additional, and Bermúdez, Valmore, additional

Published
2023
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21. Glomerular and tubular effects of dapagliflozin, eplerenone and their combination in patients with chronic kidney disease: A post‐hoc analysis of the ROTATE‐3 study.

Author

Lieverse, Tom T. G. F., Puchades, Maria J., Mulder, Udo D. J., Provenzano, Michele, Krenning, Guido, Jongs, Niels, Wink, Simon E., Slart, Riemer H. J. A., Andreucci, Michele, D'Marco, Luis, De Nicola, Luca, Gorriz, Jose L., and Heerspink, Hiddo J. L.

Subjects
COPEPTINS, CHRONIC kidney failure, CHRONICALLY ill, DAPAGLIFLOZIN, MINERALOCORTICOID receptors, KIDNEY failure
Abstract

Aim: Sodium‐glucose co‐transporter 2 inhibitors and mineralocorticoid receptor antagonists reduce albuminuria and the risk of kidney failure. The aim of this study was to investigate the effects of both agents alone and in combination on markers of the glomerular endothelial glycocalyx and tubular function. Methods: This post‐hoc analysis utilized data of the ROTATE‐3 study, a randomized cross‐over study in 46 adults with chronic kidney disease and urinary albumin excretion ≥100 mg/24 h, who were treated for 4 weeks with dapagliflozin, eplerenone or its combination. The effects of dapagliflozin, eplerenone and the combination on outcome measures such as heparan sulphate, neuro‐hormonal markers and tubular sodium handling were assessed with mixed repeated measures models. Results: The mean percentage change from baseline in heparan sulphate after 4 weeks treatment with dapagliflozin, eplerenone or dapagliflozin‐eplerenone was −34.8% (95% CI −52.2, −10.9), −5.9% (95% CI −32.5, 31.3) and −28.1% (95% CI −48.4, 0.1) respectively. The mean percentage change from baseline in plasma aldosterone was larger with eplerenone [38.9% (95% CI 2.8, 87.7)] and dapagliflozin‐eplerenone [32.2% (95% CI −1.5, 77.4)], compared with dapagliflozin [−12.5% (95% CI −35.0, 17.8)], respectively. Mean percentage change from baseline in copeptin with dapagliflozin, eplerenone or dapagliflozin‐eplerenone was 28.4% (95% CI 10.7, 49.0), 4.2% (95% CI −10.6, 21.4) and 23.8% (95% CI 6.6, 43.9) respectively. Dapagliflozin decreased proximal absolute sodium reabsorption rate by 455.9 mmol/min (95% CI −879.2, −32.6), while eplerenone decreased distal absolute sodium reabsorption rate by 523.1 mmol/min (95% CI −926.1, −120.0). Dapagliflozin‐eplerenone decreased proximal absolute sodium reabsorption [−971.0 mmol/min (95% CI −1411.0, −531.0)], but did not affect distal absolute sodium reabsorption [−9.2 mmol/min (95% CI −402.0, 383.6)]. Conclusions: Dapagliflozin and eplerenone exert different effects on markers of glomerular and tubular function supporting the hypothesis that different mechanistic pathways may account for their kidney protective effects. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Role of the Nephrologist in Non-Kidney Solid Organ Transplant (NKSOT)

Author

Viejo-Boyano, Iris, primary, López-Romero, Luis Carlos, additional, D’Marco, Luis, additional, Checa-Ros, Ana, additional, Peris-Fernández, María, additional, Garrigós-Almerich, Enrique, additional, Ramos-Tomás, María Carmen, additional, Peris-Domingo, Ana, additional, and Hernández-Jaras, Julio, additional

Published
2023
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25. Exploring the Link between Cardiorenal and Metabolic Diseases.

Author

D'Marco, Luis and Checa-Ros, Ana

Subjects
METABOLIC disorder diagnosis, DISEASE progression, BIOMARKERS, HEALTH services accessibility, INFLAMMATION, POLYPHARMACY, METABOLIC disorders, OXIDATIVE stress, TYPE 2 diabetes, HYPERLIPIDEMIA, RISK assessment, TREATMENT effectiveness, HEALTH behavior, INTERPROFESSIONAL relations, HEALTH care teams, HEALTH equity, ARRHYTHMIA, CARDIO-renal syndrome, BEHAVIOR modification, EARLY diagnosis, CAUSALITY (Physics)
Published
2023
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26. Silver jubilee: 25 years of the first demonstration of the direct effect of phosphate on the parathyroid cell

Author

Bover, Jordi, primary, Trinidad, Pedro, additional, Jara, Aquiles, additional, Soler-Majoral, Jordi, additional, Martín-Malo, Alejandro, additional, Torres, Armando, additional, Frazão, João, additional, Ureña, Pablo, additional, Dusso, Adriana, additional, Arana, Carolt, additional, Graterol, Fredzzia, additional, Romero-González, Gregorio, additional, Troya, Maribel, additional, Samaniego, Diana, additional, D’Marco, Luis, additional, Valdivielso, José Manuel, additional, Fernández, Elvira, additional, Arenas, María Dolores, additional, Torregrosa, Vicente, additional, Navarro-González, Juan F., additional, Lloret, María Jesús, additional, Ballarín, J.A., additional, Bosch, Ricardo J, additional, Górriz, José L., additional, de Francisco, AGL, additional, Gutiérrez, Orlando, additional, Ara, Jordi, additional, Felsenfeld, Arnold, additional, Canalejo, Antonio, additional, and Almadén, Yolanda, additional

Published
2023
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29. SARS-CoV-2-Spike Antibody and T-Cell Responses Elicited by a Homologous Third mRNA COVID-19 Dose in Hemodialysis and Kidney Transplant Recipients

Author

Panizo, Nayara, primary, Giménez, Estela, additional, Albert, Eliseo, additional, Zulaica, Joao, additional, Rodríguez-Moreno, Alicia, additional, Rusu, Luciana, additional, Giménez-Civera, Elena, additional, Puchades, Maria Jesús, additional, D’Marco, Luis, additional, Gandía-Salmerón, Lorena, additional, Torres, Ignacio, additional, Sancho, Asunción, additional, Gavela, Eva, additional, Gonzalez-Rico, Miguel, additional, Montomoli, Marco, additional, Perez-Baylach, Carmen Maria, additional, Bonilla, Begoña, additional, Solano, Camila, additional, Alvarado, Mª Fernanda, additional, Torregrosa, Isidro, additional, Gonzales-Candia, Boris, additional, Alcaraz, María Jesús, additional, Geller, Ron, additional, Górriz, José Luis, additional, and Navarro, David, additional

Published
2022
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33. Renal Histologic Findings in Necropsies of Type 2 Diabetes Mellitus Patients

Author

D’Marco, Luis, primary, Puchades, María Jesús, additional, Escudero-Saiz, Victor, additional, Giménez-Civera, Elena, additional, Terradez, Liria, additional, Moscardó, Anais, additional, Carbonell-Asins, Juan Antonio, additional, Pérez-Bernat, Elisa, additional, Torregrosa, Isidro, additional, Moncho, Francesc, additional, Navarro, Jorge, additional, and Górriz, José Luis, additional

Published
2022
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36. MO877: Dynamics of SARS-COV-2-Spike-Reactive Antibody and T-Cell Responses in Chronic Kidney Disease Patients Within 3 Months After Covid-19 Full Vaccination

Author

Panizo Gonzalez, Nayara, primary, Albert, Eliseo, additional, Gimenez-Civera, Elena, additional, Solano Rivera, Camila, additional, Jesús Puchades Montesa, Maria, additional, Gandia, Lorena, additional, D'marco, Luis, additional, Maria Pérez-Baylach, Carmen, additional, Bonilla, Begoña, additional, Sancho, Asunción, additional, Gavela, Eva, additional, Gonzalez-Rico, Miguel, additional, Montomoli, Marco, additional, Fernanda Alvarado, Maria, additional, Torregrosa Maicas, Isidro, additional, Navarro, David, additional, and Luis Gorriz Teruel, Jose, additional

Published
2022
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37. MO1050: Covid-19 Vaccination Improved Psychological Distress (Anxiety and Depression Scores) in Chronic Kidney Disease Patients: A Prospective Study

Author

Panizo Gonzalez, Nayara, primary, Fernanda Alvarado, Maria, additional, Garcia-Llana, Helena, additional, Gandia, Lorena, additional, Gimenez-Civera, Elena, additional, D'marco, Luis, additional, Jesãºs Puchades Montesa, Maria, additional, Sargsian, Mari, additional, Sanchis, Irina, additional, Juan-Garcia, Isabel, additional, Angel Solis, Miguel, additional, Maria Pérez-Baylach, Carmen, additional, Bonilla, Begoña, additional, Solano Rivera, Camila, additional, Moncho, Francesc, additional, Perez-Bernat, Elisa, additional, and Luis Gorriz Teruel, Jose, additional

Published
2022
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38. Dynamics of SARS-CoV-2-Spike-reactive antibody and T-cell responses in chronic kidney disease patients within 3 months after COVID-19 full vaccination

Author

Panizo, Nayara, primary, Albert, Eliseo, additional, Giménez-Civera, Elena, additional, Puchades, Maria Jesús, additional, D'Marco, Luis, additional, Gandía-Salmerón, Lorena, additional, Giménez, Estela, additional, Torre, Ignacio, additional, Sancho, Asunción, additional, Gavela, Eva, additional, Gonzalez-Rico, Miguel, additional, Montomoli, Marco, additional, Perez-Baylach, Carmen Maria, additional, Bonilla, Begoña, additional, Solano, Camila, additional, Alvarado, Mª Fernanda, additional, Torregrosa, Isidro, additional, Alcaraz, María Jesús, additional, Górriz, José Luis, additional, and Navarro, David, additional

Published
2022
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39. Coronavirus disease 2019 in chronic kidney disease

Author

D'Marco, Luis, Puchades, María Jesús, Romero Parra, María, Gimenez Civera, Elena, Soler, María José, Ortiz, Alberto, Górriz, Jose Luis, and Universitat Autònoma de Barcelona

Subjects
medicine.medical_specialty, Population, 030232 urology & nephrology, Disease, urologic and male genital diseases, Systemic inflammation, Asymptomatic, law.invention, 03 medical and health sciences, 0302 clinical medicine, cardiovascular disease, law, Chronic kidney disease, Internal medicine, Diabetes mellitus, medicine, education, CKJ Reviews, therapy, Transplantation, education.field_of_study, SARS-CoV-2, business.industry, Immunity, COVID-19, Cardiovascular disease, medicine.disease, immunity, Intensive care unit, Virus, Pneumonia, Nephrology, Therapy, medicine.symptom, business, chronic kidney disease, Kidney disease
Abstract

The clinical spectrum of coronavirus disease 2019 (COVID-19) infection ranges from asymptomatic infection to severe pneumonia with respiratory failure and even death. More severe cases with higher mortality have been reported in older patients and in those with chronic illness such as hypertension, diabetes or cardiovascular diseases. In this regard, patients with chronic kidney disease (CKD) have a higher rate of all-type infections and cardiovascular disease than the general population. A markedly altered immune system and immunosuppressed state may predispose CKD patients to infectious complications. Likewise, they have a state of chronic systemic inflammation that may increase their morbidity and mortality. In this review we discuss the chronic immunologic changes observed in CKD patients, the risk of COVID-19 infections and the clinical implications for and specific COVID-19 therapy in CKD patients. Indeed, the risk for severe COVID-19 is 3-fold higher in CKD than in non-CKD patients; CKD is 12-fold more frequent in intensive care unit than in non-hospitalized COVID-19 patients, and this ratio is higher than for diabetes or cardiovascular disease; and acute COVID-19 mortality is 15–25% for haemodialysis patients even when not developing pneumonia.

Published
2020
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40. Hipertensión, emociones y felicidad: una breve mirada desde la biología a la Psicología Positiva

Author

Bautista-Sandoval, María, Chacín, Maricarmen, Chaparro-Suárez, Yudy, Riaño-Garzón, Manuel E, Díaz-Camargo, Edgar Alexis, Duran, Pablo, Parra, Heliana, Castro, Ana, Nava, Manuel, Medina Ortiez, Oscar, D’Marco, Luis, Rojas, Edward, and Bermúdez, Valmore

Subjects
Hypertension, Happiness, Hipertensión, Enfermedad cardiovascular, Salud, Psychosocial Health, Psicosocial, Cardiovascular disease, Felicidad
Abstract

High blood pressure (HBP) is a silent disease with an extremely high prevalence worldwide. It is considered the leading risk factor for cardiovascular (CVD) and neurovascular disorders. The etiology of hypertension is based on various genetic, environmental, and social factors. Currently, compelling evidence points to the link between HBP and certain psycho-emotional factors, such as mental stability, happiness, general well-being, and fulfillment, all consistently associated with better physical and psychological health. Clinical and epidemiological evidence supports their value as a novel target in HBP management despite the lack of clarity concerning how psycho-emotional and affective states affect cardiovascular health. Among the main psycho-emotional strategies implemented to treat HBP and other CVD patients, emphasis should be placed on psychosocial interventions and positive psychology, which have shown promising results in this regard thus far. Therefore, this review aims to comprehensively determine whether an individual’s psychosocial and emotional state can be an HBP risk factor. La hipertensión arterial (HTA) es una enfermedad silenciosa con una prevalencia extremadamente alta a nivel mundial. Es considerada el principal factor de riesgo de enfermedades cardiovasculares (ECV) y neurovasculares. La etiología de la HTA se basa en diferentes factores genéticos, ambientales y sociales. Actualmente, la evidencia apunta al vínculo entre la HTA y ciertos factores psicoemocionales, como la estabilidad mental, la felicidad, el bienestar general y la realización, todos asociados consistentemente con una mejor salud física y psicológica. La evidencia clínica y epidemiológica respalda su valor como un objetivo novedoso en el manejo de la HTA a pesar de la falta de claridad sobre cómo los estados psicoemocionales y afectivos afectan la salud cardiovascular. Entre las principales estrategias psicoemocionales implementadas para el tratamiento de la HTA y otros pacientes con ECV, se encuentran las intervenciones psicosociales y la psicología positiva, que hasta el momento han mostrado resultados prometedores. Así, esta revisión tiene como objetivo determinar de manera integral si el estado psicosocial y emocional de un individuo puede ser un factor de riesgo de HTA.

Published
2022

43. COVID-19 Vaccination Improved Psychological Distress (Anxiety and Depression Scores) in Chronic Kidney Disease Patients: A Prospective Study

Author

Garcia-Llana, Helena, primary, Panizo, Nayara, additional, Gandía, Lorena, additional, Orti, Marisa, additional, Giménez-Civera, Elena, additional, Forquet, Claudia, additional, D’Marco, Luis, additional, Puchades, Maria Jesús, additional, Sargsyan, Mari, additional, Sanchís, Irina, additional, Ribera, Carmen, additional, Marco, Mª Inés, additional, Ferrá, Cristela Moncho, additional, Pérez-Baylach, Carmen María, additional, Bonilla, Begoña, additional, Moncho Francés, Francesc, additional, Perez-Bernat, Elisa, additional, Sancho, Asunción, additional, and Górriz, Jose Luis, additional

Published
2022
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44. Long-Term Prognostic Impact of Estimated Glomerular Filtration Rate on Admission in Patients Hospitalized for Acute Heart Failure

Author

de la Espriella, Rafael, primary, Navarro, Jorge, additional, Mollar, Anna, additional, D’Marco, Luis, additional, Palau, Patricia, additional, Miñana, Gema, additional, Llácer, Pau, additional, Santas, Enrique, additional, Heredia, Raquel, additional, González, Miguel, additional, Górriz, José Luis, additional, Codina, Pau, additional, Díez, Javier, additional, Bayés-Genís, Antoni, additional, and Núñez, Julio, additional

Published
2022
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47. Clinical Approach to Vascular Calcification in Patients With Non-dialysis Dependent Chronic Kidney Disease: Mineral-Bone Disorder-Related Aspects

Author

Bover, Jordi, Aguilar, Armando, Arana Aliaga, Carolt, Molina, Pablo, Lloret, María Jesús, Ochoa, Jackson, Berná, Gerson, Gutiérrez-Maza, Yessica G., Rodrigues, Natacha, D'Marco, Luis, Górriz, José L., and Universitat Autònoma de Barcelona

Subjects
Oncology, Medicine (General), medicine.medical_specialty, Mini Review, 030232 urology & nephrology, Parathyroid hormone, Phosphate, 030204 cardiovascular system & hematology, Calcification, calcification, 03 medical and health sciences, R5-920, 0302 clinical medicine, Internal medicine, Vitamin D and neurology, medicine, CKD, CKD-MBD, Vascular calcification, phosphate, Calciprotein particles, Surrogate endpoint, business.industry, Incidence (epidemiology), General Medicine, medicine.disease, Pathophysiology, vascular calcification, Insuficiència renal crònica, Medicine, calciprotein particles, business, Kidney disease
Abstract

Chronic kidney disease (CKD) is associated with a very high morbimortality, mainly from cardiovascular origin, and CKD is currently considered in the high- or very high risk- cardiovascular risk category. CKD-mineral and bone disorders (CKD-MBDs), including vascular and/or valvular calcifications, are also associated with these poor outcomes. Vascular calcification (VC) is very prevalent (both intimal and medial), even in non-dialysis dependent patients, with a greater severity and more rapid progression. Simple X-ray based-scores such as Adragão's (AS) are useful prognostic tools and AS (even AS based on hand-X-ray only) may be superior to the classic Kauppila's score when evaluating non-dialysis CKD patients. Thus, in this mini-review, we briefly review CKD-MBD-related aspects of VC and its complex pathophysiology including the vast array of contributors and inhibitors. Furthermore, although VC is a surrogate marker and is not yet considered a treatment target, we consider that the presence of VC may be relevant in guiding therapeutic interventions, unless all patients are treated with the mindset of reducing the incidence or progression of VC with the currently available armamentarium. Avoiding phosphate loading, restricting calcium-based phosphate binders and high doses of vitamin D, and avoiding normalizing (within the normal limits for the assay) parathyroid hormone levels seem logical approaches. The availability of new drugs and future studies, including patients in early stages of CKD, may lead to significant improvements not only in patient risk stratification but also in attenuating the accelerated progression of VC in CKD.

Published
2021
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48. The Role of the α Cell in the Pathogenesis of Diabetes: A World beyond the Mirror

Author

Martínez, María Sofía, primary, Manzano, Alexander, additional, Olivar, Luis Carlos, additional, Nava, Manuel, additional, Salazar, Juan, additional, D’Marco, Luis, additional, Ortiz, Rina, additional, Chacín, Maricarmen, additional, Guerrero-Wyss, Marion, additional, Cabrera de Bravo, Mayela, additional, Cano, Clímaco, additional, Bermúdez, Valmore, additional, and Angarita, Lisse, additional

Published
2021
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49. Oxidative Stress in Non-Dialysis-Dependent Chronic Kidney Disease Patients

Author

Tomás-Simó, Patricia, primary, D’Marco, Luis, additional, Romero-Parra, María, additional, Tormos-Muñoz, Mari Carmen, additional, Sáez, Guillermo, additional, Torregrosa, Isidro, additional, Estañ-Capell, Nuria, additional, Miguel, Alfonso, additional, Gorriz, José Luis, additional, and Puchades, María Jesús, additional

Published
2021
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50. Advanced Glycation End Products: New Clinical and Molecular Perspectives

Author

Salazar, Juan, primary, Navarro, Carla, additional, Ortega, Ángel, additional, Nava, Manuel, additional, Morillo, Daniela, additional, Torres, Wheeler, additional, Hernández, Marlon, additional, Cabrera, Mayela, additional, Angarita, Lissé, additional, Ortiz, Rina, additional, Chacín, Maricarmen, additional, D’Marco, Luis, additional, and Bermúdez, Valmore, additional

Published
2021
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