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2. Investigating Genetic and Environmental Substrates of the Relationship between Positive Mental Health and Biological Aging—A Study Protocol

Author

Marcon, Francesca, primary, Salemi, Miriam, additional, D’Ippolito, Cristina, additional, Picardi, Angelo, additional, Toccaceli, Virgilia, additional, Nisticò, Lorenza, additional, Alviti, Sabrina, additional, Siniscalchi, Ester, additional, Salani, Francesca, additional, Varalda, Giorgia Maria, additional, Medda, Emanuela, additional, and Fagnani, Corrado, additional

Published
2023
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5. Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project

Author

Jelenkovic, Aline, Yokoyama, Yoshie, Sund, Reijo, Pietiläinen, Kirsi H, Hur, Yoon-Mi, Willemsen, Gonneke, Bartels, Meike, van Beijsterveldt, Toos CEM, Ooki, Syuichi, Saudino, Kimberly J, Stazi, Maria A, Fagnani, Corrado, D’Ippolito, Cristina, Nelson, Tracy L, Whitfield, Keith E, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Heikkilä, Kauko, Cutler, Tessa L, Hopper, John L, Wardle, Jane, Llewellyn, Clare H, Fisher, Abigail, Corley, Robin P, Huibregtse, Brooke M, Derom, Catherine A, Vlietinck, Robert F, Loos, Ruth JF, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tarnoki, Adam D, Tarnoki, David L, Burt, S Alexandra, Klump, Kelly L, Ordoñana, Juan R, Sánchez-Romera, Juan F, Colodro-Conde, Lucia, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Harris, Jennifer R, Brandt, Ingunn, Nilsen, Thomas Sevenius, Craig, Jeffrey M, Saffery, Richard, Rasmussen, Finn, Tynelius, Per, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Haworth, Claire MA, Plomin, Robert, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato, Esther, Krueger, Robert F, McGue, Matt, Pahlen, Shandell, Boomsma, Dorret I, Sørensen, Thorkild IA, Kaprio, Jaakko, and Silventoinen, Karri

Published
2017
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10. Influence of residential land cover on childhood allergic and respiratory symptoms and diseases: Evidence from 9 European cohorts

Author

Parmes, Eija, primary, Pesce, Giancarlo, additional, Sabel, Clive E., additional, Baldacci, Sandra, additional, Bono, Roberto, additional, Brescianini, Sonia, additional, D'Ippolito, Cristina, additional, Hanke, Wojciech, additional, Horvat, Milena, additional, Liedes, Hilkka, additional, Maio, Sara, additional, Marchetti, Pierpaolo, additional, Marcon, Alessandro, additional, Medda, Emanuela, additional, Molinier, Matthieu, additional, Panunzi, Silvia, additional, Pärkkä, Juha, additional, Polańska, Kinga, additional, Prud'homme, Julie, additional, Ricci, Paolo, additional, Snoj Tratnik, Janja, additional, Squillacioti, Giulia, additional, Stazi, Maria Antonietta, additional, Maesano, Cara Nichole, additional, and Annesi-Maesano, Isabella, additional

Published
2020
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12. Influence of residential land cover on childhood allergic and respiratory symptoms and diseases: Evidence from 9 European cohorts

Author

Parmes, Eija, Pesce, Giancarlo, Sabel, Clive, Baldacci, Sandra, Bono, Roberto, Brescianini, Sonia, D'Ippolito, Cristina, Hanke, Wojciech, Horvat, Milena, Liedes, Hilkka, Maio, Sara, Marchetti, Pierpaolo, Marcon, Alessandro, Medda, Emmanuela, Molinier, Matthieu, Panunzi, Silvia, Pärkkä, Juha, Polanska, Kinga, Prud'homme, Julie, Ricci, Paolo, Snoj Tratnik, Janja, Squillacioti, Giulia, Stazi, Maria Antonietta, Maesano, Cara, Annesi-Maesano, Isabella, VTT Technical Research Centre of Finland (VTT), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Aarhus University [Aarhus], Institute of Clinical Physiology, CNR, University of Turin, Istituto Superiore di Sanita [Rome], Jozef Stefan Institute [Ljubljana] (IJS), University of Verona (UNIVR), Gestionnaire, Hal Sorbonne Université, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Università degli studi di Torino = University of Turin (UNITO), and Università degli studi di Verona = University of Verona (UNIVR)

Subjects
Green space, Land cover, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Allergy, Adolescent, [SDV]Life Sciences [q-bio], Respiratory Tract Diseases, Eczema, Forests, Environment, Asthma, Rhinitis, Allergic, [SDV] Life Sciences [q-bio], Residence Characteristics, Child, Preschool, Prevalence, Humans, Child, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, SDG 15 - Life on Land, Respiratory Sounds
Abstract

INTRODUCTION: Recent research focused on the interaction between land cover and the development of allergic and respiratory disease has provided conflicting results and the underlying mechanisms are not fully understood. In particular, green space, which confers an overall positive impact on general health, may be significantly contributing to adverse respiratory health outcomes. This study evaluates associations between surrounding residential land cover (green, grey, agricultural and blue space), including type of forest cover (deciduous, coniferous and mixed), and childhood allergic and respiratory diseases.METHODS: Data from 8063 children, aged 3-14 years, were obtained from nine European population-based studies participating in the HEALS project. Land-cover exposures within a 500 m buffer centred on each child's residential address were computed using data from the Coordination of Information on the Environment (CORINE) program. The associations of allergic and respiratory symptoms (wheeze, asthma, allergic rhinitis and eczema) with land coverage were estimated for each study using logistic regression models, adjusted for sex, age, body mass index, maternal education, parental smoking, and parental history of allergy. Finally, the pooled effects across studies were estimated using meta-analyses.RESULTS: In the pooled analyses, a 10% increase in green space coverage was significantly associated with a 5.9%-13.0% increase in the odds of wheezing, asthma, and allergic rhinitis, but not eczema. A trend of an inverse relationship between agricultural space and respiratory symptoms was observed, but did not reach statistical significance. In secondary analyses, children living in areas with surrounding coniferous forests had significantly greater odds of reporting wheezing, asthma and allergic rhinitis.CONCLUSION: Our results provide further evidence that exposure to green space is associated with increased respiratory disease in children. Additionally, our findings suggest that coniferous forests might be associated with wheezing, asthma and allergic rhinitis. Additional studies evaluating both the type of green space and its use in relation to respiratory conditions should be conducted in order to clarify the underlying mechanisms behind associated adverse impacts.

Published
2019

13. The Italian Twin Registry: An Update at 18 Years From Its Inception

Author

Medda, Emanuela, primary, Toccaceli, Virgilia, additional, Fagnani, Corrado, additional, Nisticò, Lorenza, additional, Brescianini, Sonia, additional, Salemi, Miriam, additional, Ferri, Maurizio, additional, D’Ippolito, Cristina, additional, Alviti, Sabrina, additional, Arnofi, Antonio, additional, and Stazi, Maria Antonietta, additional

Published
2019
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14. Research understanding, attitude and awareness towards biobanking: a survey among Italian twin participants to a genetic epidemiological study

Author

Brescianini Sonia, Giannantonio Lorenzo, D'Ippolito Cristina, Nisticò Lorenza, Fagnani Corrado, Toccaceli Virgilia, and Stazi Maria

Subjects
Medical philosophy. Medical ethics, R723-726
Abstract

Abstract Background The Italian Twin Registry (ITR) has been carrying out several genetic-epidemiological studies. Collection and storage of biological material from study participants has recently increased in the light of biobanking development. Within this scenario, we aimed at investigating understanding, awareness and attitude towards blood/DNA donation of research participants. About these quite unknown dimensions more knowledge is needed from ethical and social perspectives. Methods Cross-sectional mail survey to explore three dimensions: (i) understanding of aims and method of a specific study, (ii) attitude (three ideas for donation: "moral duty", "pragmatism", "spontaneity") and (iii) awareness (i.e. the recall of having been asked to donate) towards blood/DNA donation for research, among all the Italian twins who had participated in Euroclot (n = 181), a large international genetic-epidemiological study. Multivariate models were applied to investigate the association of sex, age, education and modality of Euroclot recruitment (twins enrolled in the ITR and volunteers) with the targeted dimensions. Pair-wise twin concordance for the "pragmatic" attitude was estimated in monozygotic and dizygotic pairs. Results Response rate was 56% (99 subjects); 75.8% understood the Euroclot method, only 33.3% correctly answered about the study aim. A significantly better understanding of aim and method was detected in "volunteers". Graduated subjects were more likely to understand study aim. In the overall sample, the "pragmatic" attitude to blood donation reached 76.8%, and biobanking awareness 89.9%. The latter was significantly higher among women. Monozygotic twins were more concordant than dizygotic twins for the "pragmatic" attitude towards blood/DNA donation for research. Conclusion Level of understanding of aims and methods of a specific research project seems to vary in relation to modalities of approaching research; most of the twins are well aware of having been asked to donate blood for biobanking activities, and seem to be motivated by a "pragmatic" attitude to blood/DNA donation. Genetic influences on this attitude were suggested. The framing of interests and concerns of healthy participants to genetic-epidemiological studies should be further pursued, since research, particularly for "common diseases", is increasingly relying on population surveys and biobanking.

Published
2009
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17. The Italian Twin Registry

Author

Stazi, MAntonia, Cotichini, Rodolfo, Patriarca, Valeria, D'Ippolito, Cristina, Salvetti, Marco, Ristori, Giovanni, Cannoni, Stefania, and Tosi, Roberto

Published
2001

18. Does The Sex Of One'S Co-Twin Affect Height And Bmi In Adulthood? A Study Of Dizygotic Adult Twins From 31 Cohorts

Author

Bogl, Leonie H., Jelenkovic, Aline, Vuoksimaa, Eero, Ahrenfeldt, Linda, Pietilainen, Kirsi H., Stazi, Maria A., Fagnani, Corrado, D'Ippolito, Cristina, Hur, Yoon-Mi, Jeong, Hoe-Uk, Silberg, Judy L., Eaves, Lindon J., Maes, Hermine H., Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Cutler, Tessa L., Kandler, Christian, Jang, Kerry L., Christensen, Kaare, and Skytthe, Axel

Abstract

Background: The comparison of traits in twins from opposite-sex (OS) and same-sex (SS) dizygotic twin pairs is considered a proxy measure of prenatal hormone exposure. To examine possible prenatal hormonal influences on anthropometric traits, we compared mean height, body mass index (BMI), and the prevalence of being overweight or obese between men and women from OS and SS dizygotic twin pairs.

Published
2017

19. Additional file 1: Table S1. of Does the sex of one’s co-twin affect height and BMI in adulthood? A study of dizygotic adult twins from 31 cohorts

Author

Bogl, Leonie, Jelenkovic, Aline, Vuoksimaa, Eero, Ahrenfeldt, Linda, Pietiläinen, Kirsi, Stazi, Maria, Fagnani, Corrado, D’Ippolito, Cristina, Yoon-Mi Hur, Hoe-Uk Jeong, Silberg, Judy, Lindon Eaves, Maes, Hermine, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Cutler, Tessa, Kandler, Christian, Jang, Kerry, Christensen, Kaare, Skytthe, Axel, Kyvik, Kirsten, Cozen, Wendy, Hwang, Amie, Mack, Thomas, Derom, Catherine, Vlietinck, Robert, Nelson, Tracy, Whitfield, Keith, Corley, Robin, Huibregtse, Brooke, McAdams, Tom, Eley, Thalia, Gregory, Alice, Krueger, Robert, McGue, Matt, Shandell Pahlen, Willemsen, Gonneke, Bartels, Meike, Beijsterveldt, Toos Van, Zengchang Pang, Qihua Tan, Dongfeng Zhang, Martin, Nicholas, Medland, Sarah, Montgomery, Grant, Hjelmborg, Jacob, Rebato, Esther, Swan, Gary, Krasnow, Ruth, Busjahn, Andreas, Lichtenstein, Paul, Öncel, Sevgi, Aliev, Fazil, Baker, Laura, Tuvblad, Catherine, Siribaddana, Sisira, Hotopf, Matthew, Athula Sumathipala, Fruhling Rijsdijk, Magnusson, Patrik, Pedersen, Nancy, Aslan, Anna, Ordoñana, Juan, Sánchez-Romera, Juan, Colodro-Conde, Lucia, Duncan, Glen, Buchwald, Dedra, Tarnoki, Adam, Tarnoki, David, Yokoyama, Yoshie, Hopper, John, Loos, Ruth, Dorret Boomsma, Sørensen, Thorkild, Silventoinen, Karri, and Kaprio, Jaakko

Abstract

Sample size, mean, standard deviation and range for age by cohort in females from same- and opposite-sex dizygotic twin pairs. Table S2. Sample size, mean, standard deviation, and range for age by cohort in males from same- and opposite-sex dizygotic twin pairs. Table S3. Sample size, mean, and standard deviation for height (cm) and BMI (kg/m2) by cohort in females from same- and opposite-sex dizygotic twin pairs. Table S4. Sample size, mean, and standard deviation for height (cm) and BMI (kg/m2) by cohort in males from same- and opposite-sex dizygotic twin pairs. (DOCX 45 kb)

Published
2017
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20. Genetic And Environmental Influences On Height From Infancy To Early Adulthood: An Individual-Based Pooled Analysis Of 45 Twin Cohorts

Author

Jelenkovic, Aline, Sund, Reijo, Hur, Yoon-Mi, Yokoyama, Yoshie, Hjelmborg, Jacob V. B., Moller, Soren, Honda, Chika, Magnusson, Patrik K. E., Pedersen, Nancy L., Ooki, Syuichi, Aaltonen, Sari, Stazi, Maria A., Fagnani, Corrado, D'Ippolito, Cristina, Freitas, Duarte L., Maia, Jose Antonio, Ji, Fuling, Ning, Feng, Pang, Zengchang, and Rebato, Esther

Abstract

Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1-19 years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood. Accordingly, the relative genetic contribution increased with age and was greatest in adolescence (up to 0.83 in boys and 0.76 in girls). Comparing geographic-cultural regions (Europe, North-America and Australia, and East-Asia), genetic variance was greatest in North-America and Australia and lowest in East-Asia, but the relative proportion of genetic variation was roughly similar across these regions. Our findings provide further insights into height variation during childhood and adolescence in populations representing different ethnicities and exposed to different environments.

Published
2016

21. Differences in genetic and environmental variation in adult BMI by sex, age, time period, and region: an individual-based pooled analysis of 40 twin cohorts

Author

Silventoinen, Karri, primary, Jelenkovic, Aline, additional, Sund, Reijo, additional, Yokoyama, Yoshie, additional, Hur, Yoon-Mi, additional, Cozen, Wendy, additional, Hwang, Amie E, additional, Mack, Thomas M, additional, Honda, Chika, additional, Inui, Fujio, additional, Iwatani, Yoshinori, additional, Watanabe, Mikio, additional, Tomizawa, Rie, additional, Pietiläinen, Kirsi H, additional, Rissanen, Aila, additional, Siribaddana, Sisira H, additional, Hotopf, Matthew, additional, Sumathipala, Athula, additional, Rijsdijk, Fruhling, additional, Tan, Qihua, additional, Zhang, Dongfeng, additional, Pang, Zengchang, additional, Piirtola, Maarit, additional, Aaltonen, Sari, additional, Öncel, Sevgi Y, additional, Aliev, Fazil, additional, Rebato, Esther, additional, Hjelmborg, Jacob B, additional, Christensen, Kaare, additional, Skytthe, Axel, additional, Kyvik, Kirsten O, additional, Silberg, Judy L, additional, Eaves, Lindon J, additional, Cutler, Tessa L, additional, Ordoñana, Juan R, additional, Sánchez-Romera, Juan F, additional, Colodro-Conde, Lucia, additional, Song, Yun-Mi, additional, Yang, Sarah, additional, Lee, Kayoung, additional, Franz, Carol E, additional, Kremen, William S, additional, Lyons, Michael J, additional, Busjahn, Andreas, additional, Nelson, Tracy L, additional, Whitfield, Keith E, additional, Kandler, Christian, additional, Jang, Kerry L, additional, Gatz, Margaret, additional, Butler, David A, additional, Stazi, Maria A, additional, Fagnani, Corrado, additional, D’Ippolito, Cristina, additional, Duncan, Glen E, additional, Buchwald, Dedra, additional, Martin, Nicholas G, additional, Medland, Sarah E, additional, Montgomery, Grant W, additional, Jeong, Hoe-Uk, additional, Swan, Gary E, additional, Krasnow, Ruth, additional, Magnusson, Patrik KE, additional, Pedersen, Nancy L, additional, Dahl Aslan, Anna K, additional, McAdams, Tom A, additional, Eley, Thalia C, additional, Gregory, Alice M, additional, Tynelius, Per, additional, Baker, Laura A, additional, Tuvblad, Catherine, additional, Bayasgalan, Gombojav, additional, Narandalai, Danshiitsoodol, additional, Spector, Timothy D, additional, Mangino, Massimo, additional, Lachance, Genevieve, additional, Burt, S Alexandra, additional, Klump, Kelly L, additional, Harris, Jennifer R, additional, Brandt, Ingunn, additional, Nilsen, Thomas S, additional, Krueger, Robert F, additional, McGue, Matt, additional, Pahlen, Shandell, additional, Corley, Robin P, additional, Huibregtse, Brooke M, additional, Bartels, Meike, additional, van Beijsterveldt, Catharina EM, additional, Willemsen, Gonneke, additional, Goldberg, Jack H, additional, Rasmussen, Finn, additional, Tarnoki, Adam D, additional, Tarnoki, David L, additional, Derom, Catherine A, additional, Vlietinck, Robert F, additional, Loos, Ruth JF, additional, Hopper, John L, additional, Sung, Joohon, additional, Maes, Hermine H, additional, Turkheimer, Eric, additional, Boomsma, Dorret I, additional, Sørensen, Thorkild IA, additional, and Kaprio, Jaakko, additional

Published
2017
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22. Does the sex of one’s co-twin affect height and BMI in adulthood? A study of dizygotic adult twins from 31 cohorts

Author

Bogl, Leonie H., primary, Jelenkovic, Aline, additional, Vuoksimaa, Eero, additional, Ahrenfeldt, Linda, additional, Pietiläinen, Kirsi H., additional, Stazi, Maria A., additional, Fagnani, Corrado, additional, D’Ippolito, Cristina, additional, Hur, Yoon-Mi, additional, Jeong, Hoe-Uk, additional, Silberg, Judy L., additional, Eaves, Lindon J., additional, Maes, Hermine H., additional, Bayasgalan, Gombojav, additional, Narandalai, Danshiitsoodol, additional, Cutler, Tessa L., additional, Kandler, Christian, additional, Jang, Kerry L., additional, Christensen, Kaare, additional, Skytthe, Axel, additional, Kyvik, Kirsten O., additional, Cozen, Wendy, additional, Hwang, Amie E., additional, Mack, Thomas M., additional, Derom, Catherine A., additional, Vlietinck, Robert F., additional, Nelson, Tracy L., additional, Whitfield, Keith E., additional, Corley, Robin P., additional, Huibregtse, Brooke M., additional, McAdams, Tom A., additional, Eley, Thalia C., additional, Gregory, Alice M., additional, Krueger, Robert F., additional, McGue, Matt, additional, Pahlen, Shandell, additional, Willemsen, Gonneke, additional, Bartels, Meike, additional, van Beijsterveldt, Toos C. E. M., additional, Pang, Zengchang, additional, Tan, Qihua, additional, Zhang, Dongfeng, additional, Martin, Nicholas G., additional, Medland, Sarah E., additional, Montgomery, Grant W., additional, Hjelmborg, Jacob v. B., additional, Rebato, Esther, additional, Swan, Gary E., additional, Krasnow, Ruth, additional, Busjahn, Andreas, additional, Lichtenstein, Paul, additional, Öncel, Sevgi Y., additional, Aliev, Fazil, additional, Baker, Laura A., additional, Tuvblad, Catherine, additional, Siribaddana, Sisira H., additional, Hotopf, Matthew, additional, Sumathipala, Athula, additional, Rijsdijk, Fruhling, additional, Magnusson, Patrik K. E., additional, Pedersen, Nancy L., additional, Aslan, Anna K. Dahl, additional, Ordoñana, Juan R., additional, Sánchez-Romera, Juan F., additional, Colodro-Conde, Lucia, additional, Duncan, Glen E., additional, Buchwald, Dedra, additional, Tarnoki, Adam D., additional, Tarnoki, David L., additional, Yokoyama, Yoshie, additional, Hopper, John L., additional, Loos, Ruth J. F., additional, Boomsma, Dorret I., additional, Sørensen, Thorkild I. A., additional, Silventoinen, Karri, additional, and Kaprio, Jaakko, additional

Published
2017
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23. Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994

Author

Jelenkovic, Aline, primary, Hur, Yoon-Mi, additional, Sund, Reijo, additional, Yokoyama, Yoshie, additional, Siribaddana, Sisira H, additional, Hotopf, Matthew, additional, Sumathipala, Athula, additional, Rijsdijk, Fruhling, additional, Tan, Qihua, additional, Zhang, Dongfeng, additional, Pang, Zengchang, additional, Aaltonen, Sari, additional, Heikkilä, Kauko, additional, Öncel, Sevgi Y, additional, Aliev, Fazil, additional, Rebato, Esther, additional, Tarnoki, Adam D, additional, Tarnoki, David L, additional, Christensen, Kaare, additional, Skytthe, Axel, additional, Kyvik, Kirsten O, additional, Silberg, Judy L, additional, Eaves, Lindon J, additional, Maes, Hermine H, additional, Cutler, Tessa L, additional, Hopper, John L, additional, Ordoñana, Juan R, additional, Sánchez-Romera, Juan F, additional, Colodro-Conde, Lucia, additional, Cozen, Wendy, additional, Hwang, Amie E, additional, Mack, Thomas M, additional, Sung, Joohon, additional, Song, Yun-Mi, additional, Yang, Sarah, additional, Lee, Kayoung, additional, Franz, Carol E, additional, Kremen, William S, additional, Lyons, Michael J, additional, Busjahn, Andreas, additional, Nelson, Tracy L, additional, Whitfield, Keith E, additional, Kandler, Christian, additional, Jang, Kerry L, additional, Gatz, Margaret, additional, Butler, David A, additional, Stazi, Maria A, additional, Fagnani, Corrado, additional, D'Ippolito, Cristina, additional, Duncan, Glen E, additional, Buchwald, Dedra, additional, Derom, Catherine A, additional, Vlietinck, Robert F, additional, Loos, Ruth JF, additional, Martin, Nicholas G, additional, Medland, Sarah E, additional, Montgomery, Grant W, additional, Jeong, Hoe-Uk, additional, Swan, Gary E, additional, Krasnow, Ruth, additional, Magnusson, Patrik KE, additional, Pedersen, Nancy L, additional, Dahl-Aslan, Anna K, additional, McAdams, Tom A, additional, Eley, Thalia C, additional, Gregory, Alice M, additional, Tynelius, Per, additional, Baker, Laura A, additional, Tuvblad, Catherine, additional, Bayasgalan, Gombojav, additional, Narandalai, Danshiitsoodol, additional, Lichtenstein, Paul, additional, Spector, Timothy D, additional, Mangino, Massimo, additional, Lachance, Genevieve, additional, Bartels, Meike, additional, van Beijsterveldt, Toos CEM, additional, Willemsen, Gonneke, additional, Burt, S Alexandra, additional, Klump, Kelly L, additional, Harris, Jennifer R, additional, Brandt, Ingunn, additional, Nilsen, Thomas Sevenius, additional, Krueger, Robert F, additional, McGue, Matt, additional, Pahlen, Shandell, additional, Corley, Robin P, additional, Hjelmborg, Jacob v B, additional, Goldberg, Jack H, additional, Iwatani, Yoshinori, additional, Watanabe, Mikio, additional, Honda, Chika, additional, Inui, Fujio, additional, Rasmussen, Finn, additional, Huibregtse, Brooke M, additional, Boomsma, Dorret I, additional, Sørensen, Thorkild I A, additional, Kaprio, Jaakko, additional, and Silventoinen, Karri, additional

Published
2016
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24. Author response: Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994

Author

Jelenkovic, Aline, primary, Hur, Yoon-Mi, additional, Sund, Reijo, additional, Yokoyama, Yoshie, additional, Siribaddana, Sisira H, additional, Hotopf, Matthew, additional, Sumathipala, Athula, additional, Rijsdijk, Fruhling, additional, Tan, Qihua, additional, Zhang, Dongfeng, additional, Pang, Zengchang, additional, Aaltonen, Sari, additional, Heikkilä, Kauko, additional, Öncel, Sevgi Y, additional, Aliev, Fazil, additional, Rebato, Esther, additional, Tarnoki, Adam D, additional, Tarnoki, David L, additional, Christensen, Kaare, additional, Skytthe, Axel, additional, Kyvik, Kirsten O, additional, Silberg, Judy L, additional, Eaves, Lindon J, additional, Maes, Hermine H, additional, Cutler, Tessa L, additional, Hopper, John L, additional, Ordoñana, Juan R, additional, Sánchez-Romera, Juan F, additional, Colodro-Conde, Lucia, additional, Cozen, Wendy, additional, Hwang, Amie E, additional, Mack, Thomas M, additional, Sung, Joohon, additional, Song, Yun-Mi, additional, Yang, Sarah, additional, Lee, Kayoung, additional, Franz, Carol E, additional, Kremen, William S, additional, Lyons, Michael J, additional, Busjahn, Andreas, additional, Nelson, Tracy L, additional, Whitfield, Keith E, additional, Kandler, Christian, additional, Jang, Kerry L, additional, Gatz, Margaret, additional, Butler, David A, additional, Stazi, Maria A, additional, Fagnani, Corrado, additional, D'Ippolito, Cristina, additional, Duncan, Glen E, additional, Buchwald, Dedra, additional, Derom, Catherine A, additional, Vlietinck, Robert F, additional, Loos, Ruth JF, additional, Martin, Nicholas G, additional, Medland, Sarah E, additional, Montgomery, Grant W, additional, Jeong, Hoe-Uk, additional, Swan, Gary E, additional, Krasnow, Ruth, additional, Magnusson, Patrik KE, additional, Pedersen, Nancy L, additional, Dahl-Aslan, Anna K, additional, McAdams, Tom A, additional, Eley, Thalia C, additional, Gregory, Alice M, additional, Tynelius, Per, additional, Baker, Laura A, additional, Tuvblad, Catherine, additional, Bayasgalan, Gombojav, additional, Narandalai, Danshiitsoodol, additional, Lichtenstein, Paul, additional, Spector, Timothy D, additional, Mangino, Massimo, additional, Lachance, Genevieve, additional, Bartels, Meike, additional, van Beijsterveldt, Toos CEM, additional, Willemsen, Gonneke, additional, Burt, S Alexandra, additional, Klump, Kelly L, additional, Harris, Jennifer R, additional, Brandt, Ingunn, additional, Nilsen, Thomas Sevenius, additional, Krueger, Robert F, additional, McGue, Matt, additional, Pahlen, Shandell, additional, Corley, Robin P, additional, Hjelmborg, Jacob v B, additional, Goldberg, Jack H, additional, Iwatani, Yoshinori, additional, Watanabe, Mikio, additional, Honda, Chika, additional, Inui, Fujio, additional, Rasmussen, Finn, additional, Huibregtse, Brooke M, additional, Boomsma, Dorret I, additional, Sørensen, Thorkild I A, additional, Kaprio, Jaakko, additional, and Silventoinen, Karri, additional

Published
2016
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25. Second hand smoking and shorter sleep duration in Italian 12 months old infants.

Author

Brescianini*, Sonia, primary, Gagliardi, Luigi, additional, Richiardi, Lorenzo, additional, Rusconi, Franca, additional, Brumatti, Liza Vecchi, additional, Arnofi, Antonio, additional, Alviti, Sabrina, additional, D'Ippolito, Cristina, additional, Salemi, Miriam, additional, Narduzzi, Silvia, additional, Fioravanti, Sara, additional, and Farchi, Sara, additional

Published
2016
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26. Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study

Author

Silventoinen, Karri, primary, Jelenkovic, Aline, additional, Sund, Reijo, additional, Hur, Yoon-Mi, additional, Yokoyama, Yoshie, additional, Honda, Chika, additional, Hjelmborg, Jacob vB, additional, Möller, Sören, additional, Ooki, Syuichi, additional, Aaltonen, Sari, additional, Ji, Fuling, additional, Ning, Feng, additional, Pang, Zengchang, additional, Rebato, Esther, additional, Busjahn, Andreas, additional, Kandler, Christian, additional, Saudino, Kimberly J, additional, Jang, Kerry L, additional, Cozen, Wendy, additional, Hwang, Amie E, additional, Mack, Thomas M, additional, Gao, Wenjing, additional, Yu, Canqing, additional, Li, Liming, additional, Corley, Robin P, additional, Huibregtse, Brooke M, additional, Christensen, Kaare, additional, Skytthe, Axel, additional, Kyvik, Kirsten O, additional, Derom, Catherine A, additional, Vlietinck, Robert F, additional, Loos, Ruth JF, additional, Heikkilä, Kauko, additional, Wardle, Jane, additional, Llewellyn, Clare H, additional, Fisher, Abigail, additional, McAdams, Tom A, additional, Eley, Thalia C, additional, Gregory, Alice M, additional, He, Mingguang, additional, Ding, Xiaohu, additional, Bjerregaard-Andersen, Morten, additional, Beck-Nielsen, Henning, additional, Sodemann, Morten, additional, Tarnoki, Adam D, additional, Tarnoki, David L, additional, Stazi, Maria A, additional, Fagnani, Corrado, additional, D’Ippolito, Cristina, additional, Knafo-Noam, Ariel, additional, Mankuta, David, additional, Abramson, Lior, additional, Burt, S Alexandra, additional, Klump, Kelly L, additional, Silberg, Judy L, additional, Eaves, Lindon J, additional, Maes, Hermine H, additional, Krueger, Robert F, additional, McGue, Matt, additional, Pahlen, Shandell, additional, Gatz, Margaret, additional, Butler, David A, additional, Bartels, Meike, additional, van Beijsterveldt, Toos CEM, additional, Craig, Jeffrey M, additional, Saffery, Richard, additional, Freitas, Duarte L, additional, Maia, José Antonio, additional, Dubois, Lise, additional, Boivin, Michel, additional, Brendgen, Mara, additional, Dionne, Ginette, additional, Vitaro, Frank, additional, Martin, Nicholas G, additional, Medland, Sarah E, additional, Montgomery, Grant W, additional, Chong, Youngsook, additional, Swan, Gary E, additional, Krasnow, Ruth, additional, Magnusson, Patrik KE, additional, Pedersen, Nancy L, additional, Tynelius, Per, additional, Lichtenstein, Paul, additional, Haworth, Claire MA, additional, Plomin, Robert, additional, Bayasgalan, Gombojav, additional, Narandalai, Danshiitsoodol, additional, Harden, K Paige, additional, Tucker-Drob, Elliot M, additional, Öncel, Sevgi Y, additional, Aliev, Fazil, additional, Spector, Timothy, additional, Mangino, Massimo, additional, Lachance, Genevieve, additional, Baker, Laura A, additional, Tuvblad, Catherine, additional, Duncan, Glen E, additional, Buchwald, Dedra, additional, Willemsen, Gonneke, additional, Rasmussen, Finn, additional, Goldberg, Jack H, additional, Sørensen, Thorkild IA, additional, Boomsma, Dorret I, additional, and Kaprio, Jaakko, additional

Published
2016
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27. Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts

Author

Jelenkovic, Aline, primary, Sund, Reijo, additional, Hur, Yoon-Mi, additional, Yokoyama, Yoshie, additional, Hjelmborg, Jacob v. B., additional, Möller, Sören, additional, Honda, Chika, additional, Magnusson, Patrik K. E., additional, Pedersen, Nancy L., additional, Ooki, Syuichi, additional, Aaltonen, Sari, additional, Stazi, Maria A., additional, Fagnani, Corrado, additional, D’Ippolito, Cristina, additional, Freitas, Duarte L., additional, Maia, José Antonio, additional, Ji, Fuling, additional, Ning, Feng, additional, Pang, Zengchang, additional, Rebato, Esther, additional, Busjahn, Andreas, additional, Kandler, Christian, additional, Saudino, Kimberly J., additional, Jang, Kerry L., additional, Cozen, Wendy, additional, Hwang, Amie E., additional, Mack, Thomas M., additional, Gao, Wenjing, additional, Yu, Canqing, additional, Li, Liming, additional, Corley, Robin P., additional, Huibregtse, Brooke M., additional, Derom, Catherine A., additional, Vlietinck, Robert F., additional, Loos, Ruth J. F., additional, Heikkilä, Kauko, additional, Wardle, Jane, additional, Llewellyn, Clare H., additional, Fisher, Abigail, additional, McAdams, Tom A., additional, Eley, Thalia C., additional, Gregory, Alice M., additional, He, Mingguang, additional, Ding, Xiaohu, additional, Bjerregaard-Andersen, Morten, additional, Beck-Nielsen, Henning, additional, Sodemann, Morten, additional, Tarnoki, Adam D., additional, Tarnoki, David L., additional, Knafo-Noam, Ariel, additional, Mankuta, David, additional, Abramson, Lior, additional, Burt, S. Alexandra, additional, Klump, Kelly L., additional, Silberg, Judy L., additional, Eaves, Lindon J., additional, Maes, Hermine H., additional, Krueger, Robert F., additional, McGue, Matt, additional, Pahlen, Shandell, additional, Gatz, Margaret, additional, Butler, David A., additional, Bartels, Meike, additional, van Beijsterveldt, Toos C. E. M., additional, Craig, Jeffrey M., additional, Saffery, Richard, additional, Dubois, Lise, additional, Boivin, Michel, additional, Brendgen, Mara, additional, Dionne, Ginette, additional, Vitaro, Frank, additional, Martin, Nicholas G., additional, Medland, Sarah E., additional, Montgomery, Grant W., additional, Swan, Gary E., additional, Krasnow, Ruth, additional, Tynelius, Per, additional, Lichtenstein, Paul, additional, Haworth, Claire M. A., additional, Plomin, Robert, additional, Bayasgalan, Gombojav, additional, Narandalai, Danshiitsoodol, additional, Harden, K. Paige, additional, Tucker-Drob, Elliot M., additional, Spector, Timothy, additional, Mangino, Massimo, additional, Lachance, Genevieve, additional, Baker, Laura A., additional, Tuvblad, Catherine, additional, Duncan, Glen E., additional, Buchwald, Dedra, additional, Willemsen, Gonneke, additional, Skytthe, Axel, additional, Kyvik, Kirsten O., additional, Christensen, Kaare, additional, Öncel, Sevgi Y., additional, Aliev, Fazil, additional, Rasmussen, Finn, additional, Goldberg, Jack H., additional, Sørensen, Thorkild I. A., additional, Boomsma, Dorret I., additional, Kaprio, Jaakko, additional, and Silventoinen, Karri, additional

Published
2016
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28. Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age: A Study of the CODATwins Project

Author

Jelenkovic, Aline, primary, Yokoyama, Yoshie, additional, Sund, Reijo, additional, Honda, Chika, additional, Bogl, Leonie H, additional, Aaltonen, Sari, additional, Ji, Fuling, additional, Ning, Feng, additional, Pang, Zengchang, additional, Ordoñana, Juan R., additional, Sánchez-Romera, Juan F., additional, Colodro-Conde, Lucia, additional, Burt, S. Alexandra, additional, Klump, Kelly L., additional, Medland, Sarah E., additional, Montgomery, Grant W., additional, Kandler, Christian, additional, McAdams, Tom A., additional, Eley, Thalia C., additional, Gregory, Alice M., additional, Saudino, Kimberly J., additional, Dubois, Lise, additional, Boivin, Michel, additional, Tarnoki, Adam D., additional, Tarnoki, David L., additional, Haworth, Claire M. A., additional, Plomin, Robert, additional, Öncel, Sevgi Y., additional, Aliev, Fazil, additional, Stazi, Maria A., additional, Fagnani, Corrado, additional, D’Ippolito, Cristina, additional, Craig, Jeffrey M., additional, Saffery, Richard, additional, Siribaddana, Sisira H., additional, Hotopf, Matthew, additional, Sumathipala, Athula, additional, Rijsdijk, Fruhling, additional, Spector, Timothy, additional, Mangino, Massimo, additional, Lachance, Genevieve, additional, Gatz, Margaret, additional, Butler, David A., additional, Bayasgalan, Gombojav, additional, Narandalai, Danshiitsoodol, additional, Freitas, Duarte L, additional, Maia, José Antonio, additional, Harden, K. Paige, additional, Tucker-Drob, Elliot M., additional, Kim, Bia, additional, Chong, Youngsook, additional, Hong, Changhee, additional, Shin, Hyun Jung, additional, Christensen, Kaare, additional, Skytthe, Axel, additional, Kyvik, Kirsten O., additional, Derom, Catherine A., additional, Vlietinck, Robert F., additional, Loos, Ruth J. F., additional, Cozen, Wendy, additional, Hwang, Amie E., additional, Mack, Thomas M., additional, He, Mingguang, additional, Ding, Xiaohu, additional, Chang, Billy, additional, Silberg, Judy L., additional, Eaves, Lindon J., additional, Maes, Hermine H., additional, Cutler, Tessa L., additional, Hopper, John L., additional, Aujard, Kelly, additional, Magnusson, Patrik K. E., additional, Pedersen, Nancy L., additional, Aslan, Anna K. Dahl, additional, Song, Yun-Mi, additional, Yang, Sarah, additional, Lee, Kayoung, additional, Baker, Laura A., additional, Tuvblad, Catherine, additional, Bjerregaard-Andersen, Morten, additional, Beck-Nielsen, Henning, additional, Sodemann, Morten, additional, Heikkilä, Kauko, additional, Tan, Qihua, additional, Zhang, Dongfeng, additional, Swan, Gary E., additional, Krasnow, Ruth, additional, Jang, Kerry L., additional, Knafo-Noam, Ariel, additional, Mankuta, David, additional, Abramson, Lior, additional, Lichtenstein, Paul, additional, Krueger, Robert F., additional, McGue, Matt, additional, Pahlen, Shandell, additional, Tynelius, Per, additional, Duncan, Glen E., additional, Buchwald, Dedra, additional, Corley, Robin P., additional, Huibregtse, Brooke M., additional, Nelson, Tracy L., additional, Whitfield, Keith E., additional, Franz, Carol E., additional, Kremen, William S., additional, Lyons, Michael J., additional, Ooki, Syuichi, additional, Brandt, Ingunn, additional, Nilsen, Thomas Sevenius, additional, Inui, Fujio, additional, Watanabe, Mikio, additional, Bartels, Meike, additional, van Beijsterveldt, Toos C. E. M., additional, Wardle, Jane, additional, Llewellyn, Clare H., additional, Fisher, Abigail, additional, Rebato, Esther, additional, Martin, Nicholas G., additional, Iwatani, Yoshinori, additional, Hayakawa, Kazuo, additional, Sung, Joohon, additional, Harris, Jennifer R., additional, Willemsen, Gonneke, additional, Busjahn, Andreas, additional, Goldberg, Jack H., additional, Rasmussen, Finn, additional, Hur, Yoon-Mi, additional, Boomsma, Dorret I., additional, Sørensen, Thorkild I. A., additional, Kaprio, Jaakko, additional, and Silventoinen, Karri, additional

Published
2015
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29. The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits

Author

Silventoinen, Karri, primary, Jelenkovic, Aline, additional, Sund, Reijo, additional, Honda, Chika, additional, Aaltonen, Sari, additional, Yokoyama, Yoshie, additional, Tarnoki, Adam D., additional, Tarnoki, David L., additional, Ning, Feng, additional, Ji, Fuling, additional, Pang, Zengchang, additional, Ordoñana, Juan R., additional, Sánchez-Romera, Juan F., additional, Colodro-Conde, Lucia, additional, Burt, S. Alexandra, additional, Klump, Kelly L., additional, Medland, Sarah E., additional, Montgomery, Grant W., additional, Kandler, Christian, additional, McAdams, Tom A., additional, Eley, Thalia C., additional, Gregory, Alice M., additional, Saudino, Kimberly J., additional, Dubois, Lise, additional, Boivin, Michel, additional, Haworth, Claire M. A., additional, Plomin, Robert, additional, Öncel, Sevgi Y., additional, Aliev, Fazil, additional, Stazi, Maria A., additional, Fagnani, Corrado, additional, D’Ippolito, Cristina, additional, Craig, Jeffrey M., additional, Saffery, Richard, additional, Siribaddana, Sisira H., additional, Hotopf, Matthew, additional, Sumathipala, Athula, additional, Spector, Timothy, additional, Mangino, Massimo, additional, Lachance, Genevieve, additional, Gatz, Margaret, additional, Butler, David A., additional, Bayasgalan, Gombojav, additional, Narandalai, Danshiitsoodol, additional, Freitas, Duarte L., additional, Maia, José Antonio, additional, Harden, K. Paige, additional, Tucker-Drob, Elliot M., additional, Christensen, Kaare, additional, Skytthe, Axel, additional, Kyvik, Kirsten O., additional, Hong, Changhee, additional, Chong, Youngsook, additional, Derom, Catherine A., additional, Vlietinck, Robert F., additional, Loos, Ruth J. F., additional, Cozen, Wendy, additional, Hwang, Amie E., additional, Mack, Thomas M., additional, He, Mingguang, additional, Ding, Xiaohu, additional, Chang, Billy, additional, Silberg, Judy L., additional, Eaves, Lindon J., additional, Maes, Hermine H., additional, Cutler, Tessa L., additional, Hopper, John L., additional, Aujard, Kelly, additional, Magnusson, Patrik K. E., additional, Pedersen, Nancy L., additional, Aslan, Anna K. Dahl, additional, Song, Yun-Mi, additional, Yang, Sarah, additional, Lee, Kayoung, additional, Baker, Laura A., additional, Tuvblad, Catherine, additional, Bjerregaard-Andersen, Morten, additional, Beck-Nielsen, Henning, additional, Sodemann, Morten, additional, Heikkilä, Kauko, additional, Tan, Qihua, additional, Zhang, Dongfeng, additional, Swan, Gary E., additional, Krasnow, Ruth, additional, Jang, Kerry L., additional, Knafo-Noam, Ariel, additional, Mankuta, David, additional, Abramson, Lior, additional, Lichtenstein, Paul, additional, Krueger, Robert F., additional, McGue, Matt, additional, Pahlen, Shandell, additional, Tynelius, Per, additional, Duncan, Glen E., additional, Buchwald, Dedra, additional, Corley, Robin P., additional, Huibregtse, Brooke M., additional, Nelson, Tracy L., additional, Whitfield, Keith E., additional, Franz, Carol E., additional, Kremen, William S., additional, Lyons, Michael J., additional, Ooki, Syuichi, additional, Brandt, Ingunn, additional, Nilsen, Thomas Sevenius, additional, Inui, Fujio, additional, Watanabe, Mikio, additional, Bartels, Meike, additional, van Beijsterveldt, Toos C. E. M., additional, Wardle, Jane, additional, Llewellyn, Clare H., additional, Fisher, Abigail, additional, Rebato, Esther, additional, Martin, Nicholas G., additional, Iwatani, Yoshinori, additional, Hayakawa, Kazuo, additional, Rasmussen, Finn, additional, Sung, Joohon, additional, Harris, Jennifer R., additional, Willemsen, Gonneke, additional, Busjahn, Andreas, additional, Goldberg, Jack H., additional, Boomsma, Dorret I., additional, Hur, Yoon-Mi, additional, Sørensen, Thorkild I. A., additional, and Kaprio, Jaakko, additional

Published
2015
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30. An Update on the Italian Twin Register: Advances in Cohort Recruitment, Project Building and Network Development

Author

Brescianini, Sonia, primary, Fagnani, Corrado, additional, Toccaceli, Virgilia, additional, Medda, Emanuela, additional, Nisticò, Lorenza, additional, D'Ippolito, Cristina, additional, Alviti, Sabrina, additional, Arnofi, Antonio, additional, Caffari, Bruno, additional, Delfino, Davide, additional, Ferri, Maurizio, additional, Penna, Luana, additional, Salemi, Miriam, additional, Sereni, Silvia, additional, Serino, Laura, additional, Cotichini, Rodolfo, additional, and Stazi, Maria A., additional

Published
2012
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34. The Italian Twin Register: New Cohorts and Tools, Current Projects and Future Perspectives of a Developing Resource

Author

Fagnani, Corrado, primary, Brescianini, Sonia, additional, Cotichini, Sonia, additional, D'Ippolito, Cristina, additional, Dukic, Tatjana, additional, Giannantonio, Lorenzo, additional, Medda, Emanuela, additional, Nisticò, Lorenza, additional, Patriarca, Valeria, additional, Pulciani, Simonetta, additional, Rotondi, Daniela, additional, Toccaceli, Virgilia, additional, and Stazi, Maria Antonietta, additional

Published
2006
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35. Clinical Evolution of Celiac Disease in Italy 1982-2002

Author

D'Archivio, Massimo, primary, Silano, Marco, additional, Fagnani, Corrado, additional, Scazzocchio, Beatrice, additional, Nisticò, Lorenza, additional, Giovannini, Claudio, additional, Vari', Rosaria, additional, D'Ippolito, Cristina, additional, Cotichini, Rodolfo, additional, Stazi, Maria Antonietta, additional, and De Vincenzi, Massimo, additional

Published
2004
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36. An Update on the Italian Twin Register: Advances in Cohort Recruitment, Project Building and Network Development.

Author

Brescianini, Sonia, Fagnani, Corrado, Toccaceli, Virgilia, Medda, Emanuela, Nisticò, Lorenza, D'Ippolito, Cristina, Alviti, Sabrina, Arnofi, Antonio, Caffari, Bruno, Delfino, Davide, Ferri, Maurizio, Penna, Luana, Salemi, Miriam, Sereni, Silvia, Serino, Laura, Cotichini, Rodolfo, and Stazi, Maria A.

Subjects
TWINS, PHENOTYPES, GENETIC epidemiology, MENTAL health, BIOBANKS, COHORT analysis, FOLLOW-up studies (Medicine)
Abstract

The Italian Twin Register has been in place for more than 10 years. Since its establishment, it has been focusing, on the one hand, on a continuous update of the existing information, and on the other hand, on new phenotypes and sample collection. Demographic data on about 140,000 twins have been updated using the municipality registries. The Italian Twin Register has been carrying out several new studies during the last few years. A birth cohort of twins, Multiple Births Cohort Study, has been started and the enrolment is ongoing. For this cohort, data on pregnancy and birth are collected, and periodical follow-ups are made. DNA is being collected for the twins and their parents. In the area of behavioral genetics, most efforts have been directed to psychological well being assessed with self-reported tools. Research on age-related traits continues with studies on arteriosclerosis development, early biomarkers in mild cognitive impairment, and the relation between lifestyle habits and mutagen sensitivity. The Italian Twin Register biobanking has grown in its size and in its know-how in terms of both technical issues and ethical procedures implementation. Furthermore, attitudes toward biobank-based research, together with willingness and motivation for donation, are being investigated. A valuable key resource for the Italian Twin Register is the possibility of linking twin data with disease registries. This approach has been yielding several important results, such as the recent study on the heritability of type 1 diabetes. [ABSTRACT FROM AUTHOR]

Published
2013
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37. Additional file 2: Figure S1. of Does the sex of one’s co-twin affect height and BMI in adulthood? A study of dizygotic adult twins from 31 cohorts

Author

Bogl, Leonie, Jelenkovic, Aline, Vuoksimaa, Eero, Ahrenfeldt, Linda, Pietiläinen, Kirsi, Stazi, Maria, Fagnani, Corrado, D’Ippolito, Cristina, Yoon-Mi Hur, Hoe-Uk Jeong, Silberg, Judy, Lindon Eaves, Maes, Hermine, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Cutler, Tessa, Kandler, Christian, Jang, Kerry, Christensen, Kaare, Skytthe, Axel, Kyvik, Kirsten, Cozen, Wendy, Hwang, Amie, Mack, Thomas, Derom, Catherine, Vlietinck, Robert, Nelson, Tracy, Whitfield, Keith, Corley, Robin, Huibregtse, Brooke, McAdams, Tom, Eley, Thalia, Gregory, Alice, Krueger, Robert, McGue, Matt, Shandell Pahlen, Willemsen, Gonneke, Bartels, Meike, Beijsterveldt, Toos Van, Zengchang Pang, Qihua Tan, Dongfeng Zhang, Martin, Nicholas, Medland, Sarah, Montgomery, Grant, Hjelmborg, Jacob, Rebato, Esther, Swan, Gary, Krasnow, Ruth, Busjahn, Andreas, Lichtenstein, Paul, Öncel, Sevgi, Aliev, Fazil, Baker, Laura, Tuvblad, Catherine, Siribaddana, Sisira, Hotopf, Matthew, Athula Sumathipala, Fruhling Rijsdijk, Magnusson, Patrik, Pedersen, Nancy, Aslan, Anna, Ordoñana, Juan, Sánchez-Romera, Juan, Colodro-Conde, Lucia, Duncan, Glen, Buchwald, Dedra, Tarnoki, Adam, Tarnoki, David, Yokoyama, Yoshie, Hopper, John, Loos, Ruth, Dorret Boomsma, Sørensen, Thorkild, Silventoinen, Karri, and Kaprio, Jaakko

Subjects
10. No inequality
Abstract

The differences in height (cm) between opposite sex (OS) and same sex (SS) plotted against the mean heights (cm) of the cohorts for females and males. The figure examines whether the difference in height between OS and SS twins is greater in taller cohorts. The Spearman correlations are r = −0.16 and p = 0.39 for females and r = 0.10 and p = 0.59 for males. Figure S2. The differences in BMI (kg/m2) between opposite-sex (OS) and same-sex (SS) twins plotted against the mean BMIs (kg/m2) of the cohorts for females and males. The figure examines whether the difference in BMI between OS and SS twins is greater in heavier cohorts. The Spearman correlations are r = −0.39 and p = 0.029 in females and r = 0.10 and p = 0.61 for BMI in males. (DOCX 159 kb)

38. Additional file 2: Figure S1. of Does the sex of one’s co-twin affect height and BMI in adulthood? A study of dizygotic adult twins from 31 cohorts

Author

Bogl, Leonie, Jelenkovic, Aline, Vuoksimaa, Eero, Ahrenfeldt, Linda, Pietiläinen, Kirsi, Stazi, Maria, Fagnani, Corrado, D’Ippolito, Cristina, Yoon-Mi Hur, Hoe-Uk Jeong, Silberg, Judy, Lindon Eaves, Maes, Hermine, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Cutler, Tessa, Kandler, Christian, Jang, Kerry, Christensen, Kaare, Skytthe, Axel, Kyvik, Kirsten, Cozen, Wendy, Hwang, Amie, Mack, Thomas, Derom, Catherine, Vlietinck, Robert, Nelson, Tracy, Whitfield, Keith, Corley, Robin, Huibregtse, Brooke, McAdams, Tom, Eley, Thalia, Gregory, Alice, Krueger, Robert, McGue, Matt, Shandell Pahlen, Willemsen, Gonneke, Bartels, Meike, Beijsterveldt, Toos Van, Zengchang Pang, Qihua Tan, Dongfeng Zhang, Martin, Nicholas, Medland, Sarah, Montgomery, Grant, Hjelmborg, Jacob, Rebato, Esther, Swan, Gary, Krasnow, Ruth, Busjahn, Andreas, Lichtenstein, Paul, Öncel, Sevgi, Aliev, Fazil, Baker, Laura, Tuvblad, Catherine, Siribaddana, Sisira, Hotopf, Matthew, Athula Sumathipala, Fruhling Rijsdijk, Magnusson, Patrik, Pedersen, Nancy, Aslan, Anna, Ordoñana, Juan, Sánchez-Romera, Juan, Colodro-Conde, Lucia, Duncan, Glen, Buchwald, Dedra, Tarnoki, Adam, Tarnoki, David, Yokoyama, Yoshie, Hopper, John, Loos, Ruth, Dorret Boomsma, Sørensen, Thorkild, Silventoinen, Karri, and Kaprio, Jaakko

Subjects
10. No inequality
Abstract

The differences in height (cm) between opposite sex (OS) and same sex (SS) plotted against the mean heights (cm) of the cohorts for females and males. The figure examines whether the difference in height between OS and SS twins is greater in taller cohorts. The Spearman correlations are r = −0.16 and p = 0.39 for females and r = 0.10 and p = 0.59 for males. Figure S2. The differences in BMI (kg/m2) between opposite-sex (OS) and same-sex (SS) twins plotted against the mean BMIs (kg/m2) of the cohorts for females and males. The figure examines whether the difference in BMI between OS and SS twins is greater in heavier cohorts. The Spearman correlations are r = −0.39 and p = 0.029 in females and r = 0.10 and p = 0.61 for BMI in males. (DOCX 159 kb)

39. [The covid-19 pandemic in Italy: the impact on social life and mental health].

Author

Medda E, Gigantesco A, Picardi A, Carluccio E, D'Ippolito C, Ferri M, Brescianini S, Toccaceli V, and Stazi MA

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Anxiety epidemiology, Anxiety etiology, COVID-19 psychology, Depression epidemiology, Depression etiology, Educational Status, Humans, Interpersonal Relations, Italy epidemiology, Middle Aged, Occupations, Pandemics, Prevalence, Quarantine, Stress Disorders, Post-Traumatic epidemiology, Stress Disorders, Post-Traumatic etiology, Young Adult, COVID-19 epidemiology, Diseases in Twins epidemiology, SARS-CoV-2, Social Change
Abstract

Introduction: Italy, one of the first countries to be heavily hit by the spread of the new Coronavirus, has activated precautionary measures aimed at limiting its spread. This emergency situation may be cause of psychological distress in the general population. Therefore, the Italian Twins Registry has decided to carry out an epidemiological study to investigate the social and mental health impact of the covid-19 pandemic on Italian adults., Methods: The study has a longitudinal design and is aimed at twins of all ages residing in Italy. An online questionnaire was administered to collect information on socio-economic and health status of the participants, as well as of the households during the lockdown, and on the impact of the pandemic on participants' lives. Levels and prevalence of symptoms of anxiety, stress and depression were measured using validated instruments, such as the STAI-6, IES-R and PHQ-9. This article shows the results of the first wave of the survey (June 2020)., Results: A total of 2589 twins participated in the study, with a mean age of 45 years (range 18-93 years). Covid-19's prevalence among respondents was less than 1% and about 13% of the subjects reported that, at least, one of the household's members had symptoms of covid-19. Sixty percent of the participants changed the place and way of working and a third of the sample had to completely suspend their work. About half of the sample showed symptoms of an anxiety disorder and about 10% of the subjects had symptoms of a probable post-traumatic stress or depressive disorder. Higher mean scores on the three assessment instruments were observed among women, subjects with a low level of education and those residing in the Southern of Italy. Anxiety symptoms decreased with age., Conclusion: The study shows that the pandemic has had important repercussions on the socio-economic condition and mental health of the Italian population and suggests that some individuals are more vulnerable than others.

Published
2021
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40. [DNA-microarray: new technological approaches on twin studies].

Author

Pulciani S, Di Lonardo A, Fagnani C, D'Ippolito C, Bomprezzi R, and Stazi MA

Subjects
Humans, Oligonucleotide Array Sequence Analysis methods, Twin Studies as Topic methods
Abstract

The completion of the Human Genome Project, and the innovations introduced in biotechnology are changing how to study twins. Here, we summarize some molecular studies performed on populations of discordant monozygotic twins (MZ) applying microarrays. Microarrays are an orderly arrangement of high numbers of probes (DNA, RNA or proteins), immobilized onto a matrix. The microarray approach allows a global analysis of gene expression, and therefore might point out the molecular mechanisms of MZ twins' discordance, such as epigenetic mechanisms. The application of microarray to twin studies will help better define, through bioinformatics, the role of genes and environment in the development of human diseases, thus suggesting new diagnostic and therapeutic approaches.

Published
2006

41. Assessment of reference values for selected elements in a healthy urban population.

Author

Alimonti A, Bocca B, Mannella E, Petrucci F, Zennaro F, Cotichini R, D'Ippolito C, Agresti A, Caimi S, and Forte G

Subjects
Adult, Blood, Family Health, Female, Habits, Humans, Italy, Male, Middle Aged, Normal Distribution, Sampling Studies, Serum, Surveys and Questionnaires, Urban Population, Blood Chemical Analysis standards, Elements, Mass Spectrometry, Reference Values
Abstract

Reference values for 26 elements, namely Al, Ba, Be, Bi, Ca, Cd, Co, Cr, Cu, Fe, Hg, Li, Mg, Mn, Mo, Ni, Pb, Sb, Si, Sn, Sr, Tl, V, W, Zn and Zr are proposed in serum and blood of 110 healthy adults of the urban area of Rome. They were included in the study on the basis of strict criteria of eligibility and exclusion. With the exception of Ba, Bi, Co, Cr, Ni, Sb, Sn Tl in serum, and Bi, Hg, Si, V and W in whole blood, experimental data for each all the other analytes were found to approach a normal distribution. The estimated 5-95% references ranges (in ng ml(-1)) were reported. For several elements the reference ranges observed overlapped information available in the literature. Gender, age, body mass index, smoking habits and alcohol consume were used as grouping variables. Mutual associations were observed for several elements, as follows: Be, Ca, Co, Cr, Cu, Li, Mo, Pb and Zn with sex; Ca, Pb and Si with age (< and > 45 years); Co, Cr, Mo, Sb and Tl with body mass index; Cd and Pb with smoking habit; Cr and Pb with alcohol consume.

Published
2005

42. Correlation between metal ions and clinical findings in subjects affected by Alzheimer's disease.

Author

Bomboi G, Marchione F, Sepe-Monti M, De Carolis A, Bianchi V, Medda E, Pino A, Bocca B, Forte G, D'Ippolito C, and Giubilei F

Subjects
Aged, Aged, 80 and over, Aging metabolism, Alzheimer Disease etiology, Alzheimer Disease pathology, Calcium adverse effects, Calcium metabolism, Female, Homeostasis, Humans, Iron adverse effects, Iron metabolism, Male, Mass Spectrometry, Metals adverse effects, Middle Aged, Neurofibrillary Tangles, Neuropsychological Tests, Oxidants blood, Silicon blood, Alzheimer Disease blood, Metals blood
Abstract

There is a growing interest to evaluate metals in biological fluids in Alzheimer's disease (AD). There are numerous studies on this theme, but just few papers analyzed the relationship between haematic metal concentrations and the clinical features of the disease. In this study, possible associations between clinical features of AD and the variations in serum and blood concentration of some metals, as well as the serum oxidative status and the antioxidant capacity have been investigated. Sixty subjects with AD were enrolled. Some elements correlated with gender, depression and duration of the disease. However, the most significant result was the relationship between blood Ca and Fe levels and the severity of cognitive impairment. We hypothesize that Ca and Fe might play an important role in the pathogenetic mechanisms of AD.

Published
2005

43. Discriminant analysis to study trace elements in biomonitoring: an application on neurodegenerative diseases.

Author

Pino A, Brescianini S, D'Ippolito C, Fagnani C, Alimonti A, and Stazi MA

Subjects
Adult, Aged, Alzheimer Disease blood, Female, Humans, Male, Mass Spectrometry, Middle Aged, Multiple Sclerosis blood, Parkinson Disease blood, Discriminant Analysis, Environmental Monitoring statistics & numerical data, Neurodegenerative Diseases blood, Trace Elements blood
Abstract

Quantification of 26 elements was performed in blood of patients affected by neurodegenerative pathologies, i.e., Alzheimer's disease (AD), Parkinson's disease (PD) and multiple sclerosis (MS), and of a control group to study the potential role of blood elements as markers for the different neurodegenerations. A multivariate discriminant analysis (stepwise method) was applied to determine the best set of variables to discriminate among subjects with different health status. Preliminary results show three classification functions of seven elements, namely Ca, Co, Cu, Fe, Ni, Pb and Zr.

Published
2005

44. Concentration of elements in serum of patients affected by multiple sclerosis with first demyelinating episode: a six-month longitudinal follow-up study.

Author

Visconti A, Cotichini R, Cannoni S, Bocca B, Forte G, Ghazaryan A, Santucci S, D'Ippolito C, Stazi MA, Salvetti M, Alimonti A, and Ristori G

Subjects
Adult, Antioxidants analysis, Cohort Studies, Demyelinating Diseases, Female, Follow-Up Studies, Humans, Male, Mass Spectrometry, Oxidants blood, Oxidative Stress, Silicon blood, Metals blood, Multiple Sclerosis blood
Abstract

Twenty-six chemical elements and oxidative status were determined in serum of 12 patients with first demyelinating episode and brain magnetic resonance imaging compatible with the disease at different time points. Quantifications of Al, Ba, Be, Bi, Ca, Cd, Co, Cr, Cu, Fe, Hg, Li, Mg, Mn, Mo, Ni, Pb, Sb, Si, Sn, Sr, V, Tl, W, Zn and Zr, as well as of serum oxidative status and antioxidant capacity were carried out. The results were compared with values obtained from healthy subjects living in the same geographic area. Concentration variability, expressed as coefficient of variation (CV), was evaluated over a six months longitudinal follow-up. The CV was higher for Li and Pb, while showed minimal variation for Ca, Cu, Mg and Zn--elements strictly body regulated. Significant difference (p < or = 0.05) in mean concentrations of Ba, Ca, Cd, Cr, Li, Mn, Mo, Ni, Sb, Si, Sn and Zr between patients at time 0 and controls was also found.

Published
2005

45. [Twins in biomedical research and the creation of the "National Twin Registry"].

Author

Cotichini R, Fagnani C, Patriarca V, Nisticò L, Brescianini S, Cirrincione R, D'Ippolito C, Pulciani S, Figà-Talamanca L, Cannoni S, Ristori G, Salvetti M, Tosi R, and Stazi MA

Subjects
Databases, Factual, Female, Humans, Italy, Male, Registries, Twins
Abstract

Twins are a valuable resource for the study of complex traits. The twin method is substantially based on the comparison between correlations and concordance in monozygotic (MZ) and dizygotic (DZ) twins and allows several applications in biomedical and molecular genetic research. It allows either the qualitative and quantitative evaluation of the influences that genetic and environmental factors exert on phenotypes or the estimation of trait variability. Moreover, classical genetic linkage analysis is more powerful if performed in DZ twins. However, the twin method has some pitfalls, such as the necessity that collected samples be representative of both twin and general population. For this reason, over the last few years, a number of Countries have established population-based twin registers, which guarantee the maximum level of representation and, consequently, are of extreme value for epidemiological studies. Italy is also implementing a national twin register. The following is the description of the procedure that led to the establishment of the Italian Twin Registry.

Published
2003

46. The Italian Twin Project: from the personal identification number to a national twin registry.

Author

Stazi MA, Cotichini R, Patriarca V, Brescianini S, Fagnani C, D'Ippolito C, Cannoni S, Ristori G, and Salvetti M

Subjects
Aging genetics, Alzheimer Disease epidemiology, Alzheimer Disease genetics, Autoimmune Diseases epidemiology, Autoimmune Diseases genetics, Celiac Disease epidemiology, Celiac Disease genetics, Data Collection methods, Diabetes Mellitus, Type 1 epidemiology, Diabetes Mellitus, Type 1 genetics, Diseases in Twins epidemiology, Diseases in Twins genetics, Female, Gene Library, Humans, Italy epidemiology, Male, Multiple Sclerosis epidemiology, Multiple Sclerosis genetics, Program Development, Residence Characteristics statistics & numerical data, Twin Studies as Topic statistics & numerical data, Databases, Factual statistics & numerical data, Population Surveillance methods, Records statistics & numerical data, Registries statistics & numerical data, Twin Studies as Topic methods, Twins genetics, Twins statistics & numerical data
Abstract

The unique opportunity given by the "fiscal code", an alphanumeric identification with demographic information on any single person residing in Italy, introduced in 1976 by the Ministry of Finance, allowed a database of all potential Italian twins to be created. This database contains up to now name, surname, date and place of birth and home address of about 1,300,000 "possible twins". Even though we estimated an excess of 40% of pseudo-twins, this still is the world's largest twin population ever collected. The database of possible twins is currently used in population-based studies on multiple sclerosis, Alzheimer's disease, celiac disease, and type 1 diabetes. A system is currently being developed for linking the database with data from mortality and cancer registries. In 2001, the Italian Government, through the Ministry of Health, financed a broad national research program on twin studies, including the establishment of a national twin registry. Among all the possible twins, a sample of 500,000 individuals are going to be contacted and we expect to enrol around 120,000 real twin pairs in a formal Twin Registry. According to available financial resources, a sub sample of the enrolled population will be asked to donate DNA. A biological bank from twins will be then implemented, guaranteeing information on future etiological questions regarding genetic and modifiable factors for physical impairment and disability, cancers, cardiovascular diseases and other age related chronic illnesses.

Published
2002
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