1. Project Baby Bear: Rapid precision care incorporating rWGS in 5 California children’s hospitals demonstrates improved clinical outcomes and reduced costs of care
- Author
-
Dimmock, David, Caylor, Sara, Waldman, Bryce, Benson, Wendy, Ashburner, Christina, Carmichael, Jason L, Carroll, Jeanne, Cham, Elaine, Chowdhury, Shimul, Cleary, John, D'Harlingue, Arthur, Doshi, A, Ellsworth, Katarzyna, Galarreta, Carolina I, Hobbs, Charlotte, Houtchens, Kathleen, Hunt, Juliette, Joe, Priscilla, Joseph, Maries, Kaplan, Robert H, Kingsmore, Stephen F, Knight, Jason, Kochhar, Aaina, Kronick, Richard G, Limon, Jolie, Martin, Madelena, Rauen, Katherine A, Schwarz, Adam, Shankar, Suma P, Spicer, Rosanna, Rojas, Mario Augusto, Vargas-Shiraishi, Ofelia, Wigby, Kristen, Zadeh, Neda, and Farnaes, Lauge
- Subjects
Comparative Effectiveness Research ,Pediatric ,Clinical Research ,Health Services ,Clinical Trials and Supportive Activities ,Good Health and Well Being ,California ,Cohort Studies ,Cost of Illness ,Critical Care ,Critical Illness ,Female ,Hospitals ,Pediatric ,Humans ,Infant ,Infant ,Newborn ,Male ,Medicaid ,Precision Medicine ,Prospective Studies ,Treatment Outcome ,United States ,Whole Genome Sequencing ,MediCal ,QUALY ,comparative effectiveness research ,critical care ,genetic disease ,health outcomes research ,neonatal intensive care ,pediatrics ,quality improvement ,quality-adjusted life years ,rare disease ,real-world care ,Biological Sciences ,Medical and Health Sciences ,Genetics & Heredity - Abstract
Genetic disorders are a leading contributor to mortality in neonatal and pediatric intensive care units (ICUs). Rapid whole-genome sequencing (rWGS)-based rapid precision medicine (RPM) is an intervention that has demonstrated improved clinical outcomes and reduced costs of care. However, the feasibility of broad clinical deployment has not been established. The objective of this study was to implement RPM based on rWGS and evaluate the clinical and economic impact of this implementation as a first line diagnostic test in the California Medicaid (Medi-Cal) program. Project Baby Bear was a payor funded, prospective, real-world quality improvement project in the regional ICUs of five tertiary care children's hospitals. Participation was limited to acutely ill Medi-Cal beneficiaries who were admitted November 2018 to May 2020, were
- Published
- 2021