8 results on '"D'Azzò, G."'
Search Results
2. First-line therapy of acromegaly: A statement of the A.L.I.C.E. (Acromegaly primary medical treatment Learning and Improvement with Continuous Medical Education) Study Group
- Author
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Colao, A., Martino, E., Cappabianca, P., Cozzi, R., Scanarini, M., Ghigo, E., Angeletti, G., Anile, C., Arnaldi, G., Arosio, M., Attanasio, R., Auriemma, R., Baldelli, R., Billeci, D., Borretta, G., Boscaro, M., Salvatore Cannavo, Cavagnini, F., Cirillo, S., D Arrigo, C., D Azzò, G., Marinis, L., Menis, E., Degli Uberti, E., Esposito, F., Ferone, D., Formoso, G., Gasco, V., Gasperi, M., Giordano, E., Giustina, A., Grottoli, S., La Notte, M., Lasio, G., Lombardi, G., Losa, M., Mantero, F., Mariotti, S., Marzullo, P., Mazzatenta, D., Minuto, F., Montini, M., Pacini, F., Pezzino, V., Pivonello, R., Ronchi, C., Sicolo, N., Sinisi, A., Spada, A., Tamburrano, G., Terzolo, M., Tita, P. M. B., Vigo, M. T., Colao, A., Martino, E., Cappabianca, P., Cozzi, R., Scanarini, M., Ghigo, E., Angeletti, G., Anile, C., Arnaldi, G., Arosio, M., Attanasio, R., Auriemma, R., Baldelli, R., Billeci, D., Borretta, G., Boscaro, M., Cannavò, S., Cavagnini, F., Cirillo, S., D'Arrigo, C., D'Azzò, G., De Marinis, L., De Menis, E., degli Uberti, E., Esposito, F., Ferone, D., Formoso, G., Gasco, V., Gasperi, M., Giordano, E., Giustina, A., Grottoli, S., La Notte, M., Lasio, G., Lombardi, G., Losa, M., Mantero, F., Mariotti, S., Marzullo, P., Mazzatenta, D., Minuto, F., Montini, M., Pacini, F., Pezzino, V., Pivonello, R., Ronchi, C., Sicolo, N., Sinisi, A., Spada, A., Tamburrano, G., Terzolo, M., Tita, P. M. B., and Vigo, M. T.
- Subjects
Adenoma ,medicine.medical_specialty ,Pediatrics ,Cabergoline ,Medical treatment ,business.industry ,Statement (logic) ,Endocrinology, Diabetes and Metabolism ,Guidelines ,Guideline ,medicine.disease ,Acromegaly ,Treatment ,First line therapy ,Endocrinology ,Dopamine Agonists ,Physical therapy ,medicine ,Ergolines ,Humans ,Somatostatin ,business - Published
- 2006
3. Papillary thyroid cancer incidence in the volcanic area of Sicily
- Author
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Gabriella Dardanoni, Claudia Scollo, Domenico Massimo Previtera, Francesco Vermiglio, Girolamo D'Azzò, Gabriella Pellegriti, Pasqualino Malandrino, Salvatore Arena, Marco Attard, Riccardo Vigneri, Florent de Vathaire, Francesco Frasca, Carla Giordano, Francesco Trimarchi, PELLEGRITI, G, DE VATHAIRE, F, SCOLLO, C, ATTARD, M, GIORDANO, C, ARENA, S, DARDANONI, G, FRASCA, F, MALANDRINO, P, VERMIGLIO, F, PREVITERA, DM, D'AZZÒ, G, TRIMARCHI, F, and VIGNERI, R
- Subjects
Adult ,Male ,Proto-Oncogene Proteins B-raf ,Cancer Research ,medicine.medical_specialty ,Pathology ,Adolescent ,Population ,Prevalence ,Volcanic Eruptions ,Thyroid Cancer ,Risk Assessment ,Settore MED/13 - Endocrinologia ,Papillary thyroid cancer ,Thyroid cancer, environmental factors, Sicily ,Young Adult ,Age Distribution ,Volcanoes and Thyroid Cancer ,Risk Factors ,Epidemiology ,Adenocarcinoma, Follicular ,medicine ,Humans ,Environment and Thyroid Cancer ,Registries ,Thyroid Neoplasms ,Sex Distribution ,education ,Thyroid cancer ,Sicily ,Aged ,Aged, 80 and over ,education.field_of_study ,Obstetrics ,business.industry ,Incidence (epidemiology) ,Incidence ,Thyroid ,Cancer ,Environmental Exposure ,Middle Aged ,medicine.disease ,Carcinoma, Papillary ,medicine.anatomical_structure ,Oncology ,Carcinoma, Medullary ,Mutation ,Female ,business - Abstract
BACKGROUND: The steadily increasing incidence of thyroid cancer has been attributed mostly to more sensitive thyroid nodule screening. However, various environmental factors, such as those associated with volcanic areas, cannot be excluded as risk factors. We evaluated thyroid cancer incidence in Sicily, which has a homogenous population and a province (Catania) that includes the Mt Etna volcanic area. METHODS: In a register-based epidemiological survey, we collected all incident thyroid cancers in Sicily from January 1, 2002, through December 31, 2004. The age-standardized incidence rate for the world population (ASR(w)) was calculated and expressed as the number of thyroid cancer diagnoses per 100 000 residents per year. The association of thyroid cancer incidence rate with sex, age, tumor histotype, and various environmental factors was evaluated by modeling the variation of the ASR(w). All statistical tests were two-sided. RESULTS: In 2002-2004, 1950 incident thyroid cancers were identified in Sicily (among women, ASR(w) = 17.8, 95% confidence interval [CI] = 16.9 to 18.7; and among men, ASR(w) = 3.7, 95% CI = 3.3 to 4.1). Although the percentage of thyroid cancers that were microcarcinomas (ie, < or = 10 mm) and ratio of men to women with thyroid cancer were similar in all nine Sicilian provinces, thyroid cancer incidence was statistically significantly higher in the province of Catania (among women, ASR(w) = 31.7, 95% CI = 29.1 to 34.3; and among men, ASR(w) = 6.4, 95% CI = 5.2 to 7.5) than in the rest of Sicily (among women, ASR(w) = 14.1, 95% CI = 13.2 to 15.0; and among men, ASR(w) = 3.0, 95% CI = 2.6 to 3.4) (all P values < .001). Incidence of papillary, but not follicular or medullary, cancers was statistically significantly increased in Catania province, and papillary tumors from patients in Catania more frequently carried the BRAF V600E gene mutation (55 [52%] of 106 tumors) than tumors from patients elsewhere in Sicily (68 [33%] of 205 tumors) (relative risk = 1.7, 95% CI = 1.0 to 2.8, P = .02). Cancer incidence was statistically significantly lower in rural areas than in urban areas of Sicily (P = .003). No association with mild iodine deficiency or industrial installations was found. Levels of many elements (including boron, iron, manganese, and vanadium) in the drinking water of Catania province often exceeded maximum admissible concentrations, in contrast to water in the rest of Sicily. CONCLUSION: Residents of Catania province with its volcanic region appear to have a higher incidence of papillary thyroid cancer than elsewhere in Sicily.
- Published
- 2009
4. Papillary thyroid cancer incidence in the volcanic area of Sicily.
- Author
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Pellegriti G, De Vathaire F, Scollo C, Attard M, Giordano C, Arena S, Dardanoni G, Frasca F, Malandrino P, Vermiglio F, Previtera DM, D'Azzò G, Trimarchi F, and Vigneri R
- Subjects
- Adenocarcinoma, Follicular epidemiology, Adenocarcinoma, Follicular etiology, Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Carcinoma, Medullary epidemiology, Carcinoma, Medullary etiology, Carcinoma, Papillary genetics, Female, Humans, Incidence, Male, Middle Aged, Mutation, Proto-Oncogene Proteins B-raf genetics, Registries, Risk Assessment, Risk Factors, Sex Distribution, Sicily epidemiology, Thyroid Neoplasms genetics, Young Adult, Carcinoma, Papillary epidemiology, Carcinoma, Papillary etiology, Environmental Exposure adverse effects, Thyroid Neoplasms epidemiology, Thyroid Neoplasms etiology, Volcanic Eruptions adverse effects
- Abstract
Background: The steadily increasing incidence of thyroid cancer has been attributed mostly to more sensitive thyroid nodule screening. However, various environmental factors, such as those associated with volcanic areas, cannot be excluded as risk factors. We evaluated thyroid cancer incidence in Sicily, which has a homogenous population and a province (Catania) that includes the Mt Etna volcanic area., Methods: In a register-based epidemiological survey, we collected all incident thyroid cancers in Sicily from January 1, 2002, through December 31, 2004. The age-standardized incidence rate for the world population (ASR(w)) was calculated and expressed as the number of thyroid cancer diagnoses per 100 000 residents per year. The association of thyroid cancer incidence rate with sex, age, tumor histotype, and various environmental factors was evaluated by modeling the variation of the ASR(w). All statistical tests were two-sided., Results: In 2002-2004, 1950 incident thyroid cancers were identified in Sicily (among women, ASR(w) = 17.8, 95% confidence interval [CI] = 16.9 to 18.7; and among men, ASR(w) = 3.7, 95% CI = 3.3 to 4.1). Although the percentage of thyroid cancers that were microcarcinomas (ie, < or = 10 mm) and ratio of men to women with thyroid cancer were similar in all nine Sicilian provinces, thyroid cancer incidence was statistically significantly higher in the province of Catania (among women, ASR(w) = 31.7, 95% CI = 29.1 to 34.3; and among men, ASR(w) = 6.4, 95% CI = 5.2 to 7.5) than in the rest of Sicily (among women, ASR(w) = 14.1, 95% CI = 13.2 to 15.0; and among men, ASR(w) = 3.0, 95% CI = 2.6 to 3.4) (all P values < .001). Incidence of papillary, but not follicular or medullary, cancers was statistically significantly increased in Catania province, and papillary tumors from patients in Catania more frequently carried the BRAF V600E gene mutation (55 [52%] of 106 tumors) than tumors from patients elsewhere in Sicily (68 [33%] of 205 tumors) (relative risk = 1.7, 95% CI = 1.0 to 2.8, P = .02). Cancer incidence was statistically significantly lower in rural areas than in urban areas of Sicily (P = .003). No association with mild iodine deficiency or industrial installations was found. Levels of many elements (including boron, iron, manganese, and vanadium) in the drinking water of Catania province often exceeded maximum admissible concentrations, in contrast to water in the rest of Sicily., Conclusion: Residents of Catania province with its volcanic region appear to have a higher incidence of papillary thyroid cancer than elsewhere in Sicily.
- Published
- 2009
- Full Text
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5. Follow-up of low risk patients with papillary thyroid cancer: role of neck ultrasonography in detecting lymph node metastases.
- Author
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Torlontano M, Attard M, Crocetti U, Tumino S, Bruno R, Costante G, D'Azzò G, Meringolo D, Ferretti E, Sacco R, Arturi F, and Filetti S
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- Adolescent, Adult, Biopsy, Carcinoma, Papillary blood, Carcinoma, Papillary therapy, Cohort Studies, Drug Administration Schedule, Female, Follow-Up Studies, Humans, Iodine Radioisotopes, Lymph Nodes pathology, Male, Neoplasm Recurrence, Local diagnosis, Predictive Value of Tests, Risk Factors, Sensitivity and Specificity, Thyroglobulin blood, Thyroid Neoplasms therapy, Thyroxine administration & dosage, Ultrasonography, Carcinoma, Papillary diagnostic imaging, Carcinoma, Papillary secondary, Lymphatic Metastasis diagnostic imaging, Neck diagnostic imaging, Thyroid Neoplasms pathology
- Abstract
Persistent or recurrent disease is rare in low risk patients with papillary thyroid cancer, and follow-up of these patients is a matter of debate. Neck ultrasonography (US), serum thyroglobulin (Tg), and whole body scan (WBS) after T(4) withdrawal were performed in 456 patients, followed up to 5 yr. At the end of the first year, 335 patients were Tg negative, and 121 were Tg positive; 65 of 96 patients with Tg levels between 1 and 10 ng/ml became spontaneously Tg negative after 2 yr. During follow-up, WBS discovered node metastases in 13 subjects, and US discovered node metastases in 38 subjects (31 Tg positive and 7 Tg negative). WBS did not add any information, because all WBS-positive patients were also US and Tg positive. Fifty percent of metastases were less than 1 cm and not palpable. Finally, the negative predictive value of both negative Tg and US at first follow-up was 98.8%. We suggest a first follow-up based upon US assessment and stimulated (after T(4) withdrawal or recombinant human TSH) serum Tg determination; subsequently, 1) US should not be mandatory at each examination in initially Tg- and US-negative subjects, but is strongly suggested in all other cases; 2) Tg determination should be repeated 1 yr later, after exogenous or endogenous TSH stimulation only in initially Tg-positive patients without any other evidence of residual disease; and 3) Tg measurement during therapy should be sufficient in all other cases.
- Published
- 2004
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- View/download PDF
6. [Bilateral pheochromocytoma associated with duodeno-jejunal GIST in patient with von Recklinghausen disease: report of a clinical case].
- Author
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Rizzo S, Bonomo S, Moser A, Bottura D, Castellini C, Mazzola F, Lauro E, Vicenzi L, Betresini B, Angeli G, Brazzarola P, D'Azzò G, and Rosa G
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- Humans, Male, Middle Aged, Adrenal Gland Neoplasms diagnosis, Duodenal Neoplasms diagnosis, Jejunal Neoplasms diagnosis, Neoplasms, Multiple Primary diagnosis, Neurofibromatosis 1 diagnosis, Pheochromocytoma diagnosis
- Abstract
The authors present the case of a 60-year-old male patient suffering from von Recklinghausen's disease (neurofibromatosis type I, NF1) with bilateral pheochromocytoma and occasional intraoperative reports of duodenojejunal GIST (GastroIntestinal Stromal Tumour). Through a review of the literature the authors analyze the frequency and the features of bilateral pheochromocytoma and its rare histological variant, the so-called composite pheochromocytoma, characterized by the combination of pheochromocytoma and ganglioneuroma or ganglioneuro-blastoma. Bilaterality of pheochromocytoma is more frequent in patients with familiarity for pheochromocytoma without NF1. Composite pheochromocytoma accounts for about 3% of total pheochromocytomas. In addition, the authors summarize the present knowledge about gastrointestinal stromal tumours and investigate the possible association between them and NF1 or pheochromocytoma, concluding that any such association is purely casual, while confirming the well known, genetically determined association between NF1 and pheochromocytoma.
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- 2001
7. The prognostic value of thyroid function tests in predominantly non-alcoholic cirrhotic patients: a prospective investigation.
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D'Azzò G, Pinzello GB, Pace F, Garofalo P, Craxì A, and Jannì A
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- Adult, Aged, Female, Humans, Liver Cirrhosis blood, Liver Function Tests, Male, Middle Aged, Prognosis, Prospective Studies, Radioimmunoassay, Thyroxine blood, Triiodothyronine blood, Triiodothyronine, Reverse blood, Liver Cirrhosis physiopathology, Thyroid Function Tests
- Abstract
The prognostic value of thyroid function parameters (T3, T4, rT3 and the rT3:T3 ratio) and common liver tests (serum bilirubin, albumin and prothrombin activity) was investigated on hospital admission in 100 consecutive patients with predominantly non-alcoholic liver cirrhosis. Twenty-nine out of 100 patients had a well compensated cirrhosis and their mean values of thyroid tests were similar to those of 40 healthy controls. A low T3 syndrome was found in the remaining 71 decompensated patients. In these thyroid function parameters were correlated with serum bilirubin and prothrombin activity. Moreover mean values of all thyroid and liver tests, except serum albumin, were significantly different between survivors and nonsurvivors at 3 months. To evaluate the best cut-off value which allowed to predict the outcome of patients, the Receiver Operating Characteristics (ROC) curves were generated for each test by plotting the values obtained in survivors at 3 months (true positives) vs nonsurvivors (false positives). By holding the false positive errors within 10%, the highest percentage of true positive results (i.e. patients dead at 3 months) was observed for the rT3:T3 ratio, rT3 and serum bilirubin at a cut-off point of 0.841, 55 ng/dl and 3.5 mg/dl, respectively. According to the above cut-offs the rT3:T3 ratio had the best positive predictive value (74%; 95% confidence limits 60-90%) in comparison to rT3 and bilirubin.
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- 1985
- Full Text
- View/download PDF
8. Effect of iopanoic acid on metabolic rate of L-thyroxine treated rats.
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Castro L, D'Azzò G, Garofalo P, Savoia G, and Jannì A
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- Animals, Drug Interactions, Male, Rats, Rats, Inbred Strains, Thyroid Hormones blood, Basal Metabolism drug effects, Iopanoic Acid pharmacology, Thyroxine pharmacology
- Published
- 1986
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