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219 results on '"D'Antonio, Adriana"'

4. Prognostic value of myocardial perfusion imaging by cadmium zinc telluride single-photon emission computed tomography in patients with suspected or known coronary artery disease: a systematic review and meta-analysis

Author

Assante, Roberta, Zampella, Emilia, Cantoni, Valeria, Green, Roberta, D’Antonio, Adriana, Mannarino, Teresa, Gaudieri, Valeria, Nappi, Carmela, Buongiorno, Pietro, Panico, Mariarosaria, Petretta, Mario, Cuocolo, Alberto, and Acampa, Wanda

Published
2023
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16. Effect of changes in perfusion defect size during serial stress myocardial perfusion imaging on cardiovascular outcomes in patients treated with primary percutaneous coronary intervention after myocardial infarction

Author

Zampella, Emilia, Mannarino, Teresa, Gaudieri, Valeria, D’Antonio, Adriana, Giallauria, Francesco, Assante, Roberta, Cantoni, Valeria, Green, Roberta, Mainolfi, Ciro Gabriele, Nappi, Carmela, Genova, Andrea, Petretta, Mario, Cuocolo, Alberto, and Acampa, Wanda

Published
2022
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28. State of the art of 18F-FDG PET/CT application in inflammation and infection: a guide for image acquisition and interpretation

Author

Casali, Massimiliano, Lauri, Chiara, Altini, Corinna, Bertagna, Francesco, Cassarino, Gianluca, Cistaro, Angelina, Erba, Anna Paola, Ferrari, Cristina, Mainolfi, Ciro Gabriele, Palucci, Andrea, Prandini, Napoleone, Baldari, Sergio, Bartoli, Francesco, Bartolomei, Mirco, D’Antonio, Adriana, Dondi, Francesco, Gandolfo, Patrizia, Giordano, Alessia, Laudicella, Riccardo, Massollo, Michela, Nieri, Alberto, Piccardo, Arnoldo, Vendramin, Laura, Muratore, Francesco, Lavelli, Valentina, Albano, Domenico, Burroni, Luca, Cuocolo, Alberto, Evangelista, Laura, Lazzeri, Elena, Quartuccio, Natale, Rossi, Brunella, Rubini, Giuseppe, Sollini, Martina, Versari, Annibale, and Signore, Alberto

Published
2021
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29. Cardiovascular risk factors and development of nomograms in an Italian cohort of patients with suspected coronary artery disease undergoing SPECT or PET stress myocardial perfusion imaging.

Author

Megna, Rosario, Petretta, Mario, Nappi, Carmela, Assante, Roberta, Zampella, Emilia, Gaudieri, Valeria, Mannarino, Teresa, D'Antonio, Adriana, Green, Roberta, Cantoni, Valeria, Panico, Mariarosaria, Acampa, Wanda, and Cuocolo, Alberto

Subjects
RISK assessment, STATISTICAL models, SINGLE-photon emission computed tomography, RECEIVER operating characteristic curves, T-test (Statistics), MULTIPLE regression analysis, CARDIOVASCULAR diseases risk factors, DECISION making in clinical medicine, POSITRON emission tomography, DISEASE prevalence, MULTIVARIATE analysis, DESCRIPTIVE statistics, CHI-squared test, PERFUSION imaging, LONGITUDINAL method, ODDS ratio, CARDIAC contraction, CORONARY artery disease, PERFUSION, COMPARATIVE studies, CONFIDENCE intervals, DATA analysis software, DISEASE risk factors
Abstract

Introduction: Single-photon emission computed tomography (SPECT) and positron emission tomography (PET) are non-invasive nuclear medicine techniques that can identify areas of abnormal myocardial perfusion. We assessed the prevalence of cardiovascular risk factors in patients with suspected coronary artery disease (CAD) undergoing SPECT or PET stress myocardial perfusion imaging (MPI). Based on significant risk factors associated with an abnormal MPI, we developed a nomogram for each cohort as a pretest that would be helpful in decision-making for clinicians. Methods: A total of 6,854 patients with suspected CAD who underwent stress myocardial perfusion imaging by SPECT or PET/CT was studied. As part of the baseline examination, clinical teams collected information on traditional cardiovascular risk factors: age, gender, body mass index, angina, dyspnea, diabetes, hypertension, hyperlipidemia, family history of CAD, and smoking. Results: The prevalence of cardiovascular risk factors was different in the two cohorts of patients undergoing SPECT (n = 4,397) or PET (n = 2,457) myocardial perfusion imaging. A statistical significance was observed in both cohorts for age, gender, and diabetes. At multivariable analysis, only age and male gender were significant covariates in both cohorts. The risk of abnormal myocardial perfusion imaging related to age was greater in patients undergoing PET (odds ratio 4% vs. 1% per year). In contrast, male gender odds ratio was slightly higher for SPECT compared to PET (2.52 vs. 2.06). In the SPECT cohort, smoking increased the risk of abnormal perfusion of 24%. Among patients undergoing PET, diabetes and hypertension increased the risk of abnormal perfusion by 63% and 37%, respectively. For each cohort, we obtained a nomogram by significant risk factors at multivariable logistic regression. The area under the receiver operating characteristic curve associated with the nomogram was 0.67 for SPECT and 0.73 for the PET model. Conclusions: Patients with suspected CAD belonging to two different cohorts undergoing SPECT or PET stress myocardial perfusion imaging can have different cardiovascular risk factors associated with a higher risk of an abnormal MPI study. As crude variables, age, gender, and diabetes were significant for both cohorts. Net of the effect of other covariates, age and gender were the only risk factors in common between the two cohorts. Furthermore, smoking and type of stress test were significant for the SPECT cohort, where as diabetes and hypertension were significant for the PET cohort. Nomograms obtained by significant risk factors for the two cohorts can be used by clinicians to evaluate the risk of an abnormal study. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Age-Specific Cardiovascular Risk Factors for Major Adverse Cardiac Events in Patients Undergoing Myocardial Perfusion Imaging

Author

Megna, Rosario, primary, Petretta, Mario, additional, Nappi, Carmela, additional, Assante, Roberta, additional, Zampella, Emilia, additional, Gaudieri, Valeria, additional, Mannarino, Teresa, additional, D’Antonio, Adriana, additional, Green, Roberta, additional, Cantoni, Valeria, additional, Panico, Mariarosaria, additional, Acampa, Wanda, additional, and Cuocolo, Alberto, additional

Published
2023
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36. Prognostic Value of Myocardial Perfusion Imaging by Cadmium Zinc Telluride Single-photon Emission Computed Tomography in Patients with Suspected or Known Coronary Artery Disease A Systematic Review and Meta-analysis

Author

Acampa, Wanda, primary, Assante, Roberta, additional, zampella, Emilia, additional, Cantoni, Valeria, additional, Green, Roberta, additional, D'Antonio, Adriana, additional, mannarino, teresa, additional, Gaudieri, Valeria, additional, Nappi, Carmela, additional, Buongiorno, Pietro, additional, Panico, Mariarosaria, additional, Petretta, Mario, additional, and Cuocolo, Alberto, additional

Published
2023
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39. Prediction of outcome by 82Rb PET/CT in patients with ischemia and nonobstructive coronary arteries.

Author

Zampella, Emilia, Mannarino, Teresa, D'Antonio, Adriana, Assante, Roberta, Gaudieri, Valeria, Buongiorno, Pietro, Panico, Mariarosaria, Cantoni, Valeria, Green, Roberta, Nappi, Carmela, Arumugam, Parthiban, Petretta, Mario, Cuocolo, Alberto, and Acampa, Wanda

Abstract

Background: The purpose of this study was to assess the prognostic value of cardiac 82Rb positron emission tomography (PET)/computed tomography (CT) imaging in patients with myocardial ischemia of nonobstructive coronary arteries (INOCA). Methods: We retrospectively evaluated 311 INOCA patients who underwent rest stress 82Rb PET/CT. Cardiac end points were cardiac death, myocardial infarction, or late coronary revascularization. A parametric survival model was also used to identify how the variables influenced time to event. Results: During a median follow-up of 37 months (range 6–108), 23 (7%) cardiac events occurred. In patients with events total perfusion defect (TPD) was higher and myocardial flow reserve (MFR) lower compared to those without events (both P <.001). At multivariable Cox analysis, increased TPD (i.e., ≥ 5%) and reduced MFR (i.e., < 2) were predictors of events (both P <.001). At Weibull survival analysis, the highest probability of cardiac events and risk acceleration were observed in patients with both increased TPD and reduced MFR. Annualized event rate was higher in patients with reduced MFR compared to those with preserved MFR (P <.001). Conclusion: In patients with INOCA, the combined evaluation of myocardial perfusion and coronary vascular function by 82Rb PET/CT is able to identify those at higher risk of cardiac events. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Cardiac Perfusion and Innervation Assessment by CZT-SPECT: Have a Look to Simultaneous Dual-isotope Protocol.

Author

D'Antonio, Adriana, Falzarano, Maria, Reina, Fabrizio, Assante, Roberta, Zampella, Emilia, Maio, Francesca, Buongiorno, Pietro, Panico, Mariarosaria, Mainolfi, Ciro Gabriele, Mannarino, Teresa, Cuocolo, Alberto, and Acampa, Wanda

Abstract

Purpose of Review: The purpose of this review is to provide a summary on the status of the art of simultaneous perfusion-innervation imaging by CZT-SPECT and to clarify its potential applications in clinical practice. Recent Findings: Introduction of CZT cameras represented a critical breakthrough in nuclear cardiology. Although it has been demonstrated that cardiac innervation may be easily assessed by CZT-SPECT, as for now, there are only few studies investigating cardiac perfusion and innervation with simultaneous dual-isotope imaging by CZT cameras. Summary: Perfusion and innervation assessment by CZT camera is a feasible tool, allowing to reduce radiation dose exposure and acquisition time, thanks to CZT better spatial, temporal, and energy resolution, with higher compliance by patients. Moreover, this technique allows to integrate regional evaluation of myocardial perfusion/innervation status, providing more accurate information for risk stratification of different cardiac disease. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Exploring coronary microvascular function by quantitative CZT-SPECT: a small step or giant leap for INOCA patients?

Author

D'Antonio, Adriana and Mannarino, Teresa

Subjects
*SINGLE-photon emission computed tomography, *MYOCARDIAL perfusion imaging
Abstract

In the wide coronary artery disease (CAD) scenario, ischemia with nonobstructive coronary arteries (INOCA) represents a challenging condition, both for the late diagnosis and unfavorable prognosis [[1]-[3]]. Nevertheless, these patients present an increased occurrence of major adverse cardiovascular events (MACEs) at long-term follow-up, highlighting the need for an early diagnosis to improve risk stratification and management of INOCA patients [[3], [9]]. Standard myocardial perfusion imaging (MPI), both by single photon emission computed tomography (SPECT) and positron emission tomography (PET), is useful to identify INOCA patients with abnormal perfusion at higher risk of MACEs. [Extracted from the article]

Published
2023
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42. Incremental value of 18F-FDG cardiac PET imaging over dobutamine stress echocardiography in predicting myocardial ischemia in patients with suspected coronary artery disease.

Author

Zampella, Emilia, Assante, Roberta, Acampa, Wanda, Gaudieri, Valeria, Nappi, Carmela, Mannarino, Teresa, D'Antonio, Adriana, Buongiorno, Pietro, Panico, Mariarosaria, Mainolfi, Ciro Gabriele, Spinelli, Letizia, Petretta, Mario, and Cuocolo, Alberto

Abstract

Background: To assess the incremental value of 18F-fluorodeoxyglucose (FDG) cardiac positron emission tomography (PET) over dobutamine stress echocardiography (DSE) in predicting myocardial ischemia in patients with suspected coronary artery disease (CAD). Methods: Forty-one patients with suspected CAD underwent within 7 days apart rest-stress cardiac PET with 82Rb and DSE followed by cardiac 18F-FDG PET imaging. 18F-FDG images were scored on a 0 (no discernible uptake) to 2 (intense uptake) scale. Logistic regression analysis was performed to identify predictors of stress-induced ischemia. The incremental value of 18F-FDG PET over DSE in detecting ischemia at 82Rb PET cardiac imaging was assessed by the likelihood ratio chi-square and net reclassification index. Results: On 82Rb-PET imaging, myocardial ischemia (ischemic total perfusion defect ≥ 5%) was detected in 20 (49%) patients. Inducible ischemia was found in 22 (54%) patients on DSE (biphasic or worsening response pattern in ≥ 1 segment) and in 21 (51%) patients on 18F-FDG PET (uptake score of 2 in ≥ 1 segment). 18F-FDG PET resulted as statistically significant predictor of ischemia on 82Rb-PET. The addition of 18F-FDG PET to DSE increased the likelihood of ischemia on 82Rb-PET (P <.05). 18F-FDG PET was able to reclassify the probability of stress-induced myocardial ischemia on both patient and vessel analyses. Conclusion: 18F-FDG PET performed after dobutamine stress test may provide incremental value to DSE in the evaluation of myocardial ischemia. These results suggest that stress-induced myocardial ischemia can be imaged directly using 18F-FDG PET after dobutamine stress test. [ABSTRACT FROM AUTHOR]

Published
2022
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43. A Comparison among Different Machine Learning Pretest Approaches to Predict Stress-Induced Ischemia at PET/CT Myocardial Perfusion Imaging

Author

Megna, Rosario, primary, Petretta, Mario, additional, Assante, Roberta, additional, Zampella, Emilia, additional, Nappi, Carmela, additional, Gaudieri, Valeria, additional, Mannarino, Teresa, additional, D’Antonio, Adriana, additional, Green, Roberta, additional, Cantoni, Valeria, additional, Arumugam, Parthiban, additional, Acampa, Wanda, additional, and Cuocolo, Alberto, additional

Published
2021
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44. Incremental value of 18F-FDG cardiac PET imaging over dobutamine stress echocardiography in predicting myocardial ischemia in patients with suspected coronary artery disease

Author

Zampella, Emilia, primary, Assante, Roberta, additional, Acampa, Wanda, additional, Gaudieri, Valeria, additional, Nappi, Carmela, additional, Mannarino, Teresa, additional, D’Antonio, Adriana, additional, Buongiorno, Pietro, additional, Panico, Mariarosaria, additional, Mainolfi, Ciro Gabriele, additional, Spinelli, Letizia, additional, Petretta, Mario, additional, and Cuocolo, Alberto, additional

Published
2021
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45. Impact of COVID-19 infection on short-term outcome in patients referred to stress myocardial perfusion imaging

Author

Assante, Roberta, primary, D’Antonio, Adriana, additional, Mannarino, Teresa, additional, Gaudieri, Valeria, additional, Zampella, Emilia, additional, Mainolfi, Ciro Gabriele, additional, Cantoni, Valeria, additional, Green, Roberta, additional, Caiazzo, Elisa, additional, Nappi, Carmela, additional, Criscuolo, Emanuele, additional, Bologna, Roberto, additional, Zumbo, Giulia, additional, Petretta, Mario, additional, Cuocolo, Alberto, additional, and Acampa, Wanda, additional

Published
2021
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46. Correction to: Relation between myocardial blood flow and cardiac events in diabetic patients with suspected coronary artery disease and normal myocardial perfusion imaging

Author

Assante, Roberta, primary, Mainolfi, Ciro Gabriele, additional, Zampella, Emilia, additional, Gaudieri, Valeria, additional, Nappi, Carmela, additional, Mannarino, Teresa, additional, D’Antonio, Adriana, additional, Arumugam, Parthiban, additional, Petretta, Mario, additional, Cuocolo, Alberto, additional, and Acampa, Wanda, additional

Published
2021
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47. External validation of the CRAX2MACE model in an Italian cohort of patients with suspected coronary artery disease undergoing stress myocardial perfusion imaging

Author

Megna, Rosario, primary, Petretta, Mario, additional, Assante, Roberta, additional, Zampella, Emilia, additional, Nappi, Carmela, additional, Gaudieri, Valeria, additional, Mannarino, Teresa, additional, Green, Roberta, additional, Cantoni, Valeria, additional, Buongiorno, Pietro, additional, D’Antonio, Adriana, additional, Acampa, Wanda, additional, and Cuocolo, Alberto, additional

Published
2021
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48. Comparing the Prognostic Value of Stress Myocardial Perfusion Imaging by Conventional and Cadmium-Zinc Telluride Single-Photon Emission Computed Tomography through a Machine Learning Approach

Author

Cantoni, Valeria, primary, Green, Roberta, additional, Ricciardi, Carlo, additional, Assante, Roberta, additional, Donisi, Leandro, additional, Zampella, Emilia, additional, Cesarelli, Giuseppe, additional, Nappi, Carmela, additional, Sannino, Vincenzo, additional, Gaudieri, Valeria, additional, Mannarino, Teresa, additional, Genova, Andrea, additional, De Simini, Giovanni, additional, Giordano, Alessia, additional, D’Antonio, Adriana, additional, Acampa, Wanda, additional, Petretta, Mario, additional, and Cuocolo, Alberto, additional

Published
2021
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49. Effect of changes in perfusion defect size during serial stress myocardial perfusion imaging on cardiovascular outcomes in patients treated with primary percutaneous coronary intervention after myocardial infarction

Author

Zampella, Emilia, primary, Mannarino, Teresa, additional, Gaudieri, Valeria, additional, D’Antonio, Adriana, additional, Giallauria, Francesco, additional, Assante, Roberta, additional, Cantoni, Valeria, additional, Green, Roberta, additional, Mainolfi, Ciro Gabriele, additional, Nappi, Carmela, additional, Genova, Andrea, additional, Petretta, Mario, additional, Cuocolo, Alberto, additional, and Acampa, Wanda, additional

Published
2021
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