6 results on '"D'Angelo, Dario"'
Search Results
2. Analysis of Dust Fires and Explosions in the Food Processing Industry.
- Author
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Perelli, Sara, D’Angelo, Dario, and Pellegrini, Lorenzo
- Subjects
DUST explosions ,FOOD industry ,HAZARDOUS substances ,INDUSTRIAL safety ,IGNITION temperature - Abstract
Nearly all solid granular foods and powdered ingredients, such as sugar, flour, grain, spices, starch, and powdered flavors, have the capacity to sustain a combustion. This may result often in dust fires, originating from dust layers and heaps, and sometimes also in violent explosions, when the dust is suspended and a cloud is formed. Many factors affect the explosion violence or the ignition sensitivity of a dust cloud: these can be related to physical properties of the solid material (particle size, moisture content, minimum ignition temperature, etc.) and to the geometry of the system involved in the explosion (closed vessels, long pipes, degree of turbulence, etc.). While the conditions to have an explosion occur rarely in processing buildings, hazardous dust clouds regularly form during bin filling, powder conveying, or dust collection. The scope of this paper is to review a selection of incidents occurred in the past involving solid food materials and analyze them against the current best industrial practices regarding explosion prevention and protection. Particular attention will be given to the analysis of potential ignition sources and their effectiveness in igniting the flammable dust atmosphere. A selection of “lessons learnt” will also be derived from the analysis of the incidents. Lastly, the paper shall discuss the most recent trends of combustible dust fires and explosions among other industry sectors (pharmaceutical, wood processing, chemical, energy production), to gain insights about potential areas of improvement to advance in people and plant safety. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
3. Commingle Zubair Shale Sand Sequences by Using Deformable Sealing Polymer in Customized Drilling Fluid, Case Histories from Kuwait
- Author
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Al-Ajmi, Abdullah, additional, Al-Rushoud, Abdulaziz, additional, Gohain, Ashis, additional, Khatib, Faiz I, additional, Al-Naqa, Faisal, additional, Al-Mutawa, Faisal, additional, Al-Gharib, Majed, additional, Birthariya, Sudhir, additional, Mago, Ankit, additional, Al-Mekhlef, Alanoud, additional, Al-Tarkeet, Bader, additional, AlAli, Yaqoub, additional, Rossi, Arnaldo, additional, D'Angelo, Dario, additional, Spagnoli, Nazareno, additional, Samaan, Fady, additional, Rane, Praful, additional, and Scolari, Alberto, additional
- Published
- 2018
- Full Text
- View/download PDF
4. Oxidative Stress Mediates the Antiproliferative Effects of Nelfinavir in Breast Cancer Cells
- Author
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Soprano, Maria, primary, Sorriento, Daniela, additional, Rusciano, Maria Rosaria, additional, Maione, Angela Serena, additional, Limite, Gennaro, additional, Forestieri, Pietro, additional, D’Angelo, Dario, additional, D’Alessio, Matteo, additional, Campiglia, Pietro, additional, Formisano, Pietro, additional, Iaccarino, Guido, additional, Bianco, Roberto, additional, and Illario, Maddalena, additional
- Published
- 2016
- Full Text
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5. Oxidative stress mediates the antiproliferative effects of nelfinavir in breast cancer cells
- Author
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Pietro Forestieri, Gennaro Limite, Maria Rosaria Rusciano, Roberto Bianco, Maria Soprano, Matteo D’Alessio, D. Sorriento, Maddalena Illario, Dario D’Angelo, Pietro Formisano, Guido Iaccarino, Angela Serena Maione, Pietro Campiglia, Soprano, Maria, Sorriento, Daniela, Rusciano, Maria Rosaria, Maione, Angela Serena, Limite, Gennaro, Forestieri, Pietro, D'Angelo, Dario, D'Alessio, Matteo, Campiglia, Pietro, Formisano, Pietro, Iaccarino, Guido, Bianco, Roberto, and Illario, Maddalena
- Subjects
0301 basic medicine ,Cell ,Cancer Treatment ,Organic chemistry ,lcsh:Medicine ,Apoptosis ,Pharmacology ,Pathology and Laboratory Medicine ,Epithelium ,0302 clinical medicine ,Animal Cells ,immune system diseases ,Breast Tumors ,Tumor Cells, Cultured ,Medicine and Health Sciences ,Vitamin E ,Cell Cycle and Cell Division ,lcsh:Science ,Nelfinavir ,Multidisciplinary ,Oxidative Stress Mediates ,Cancer ,Cells ,Cell Death ,Medicine (all) ,virus diseases ,Vitamins ,Physical sciences ,Chemistry ,medicine.anatomical_structure ,Oncology ,Cell Processes ,030220 oncology & carcinogenesis ,Female ,Cellular Types ,Anatomy ,Research Article ,medicine.drug ,Programmed cell death ,Antineoplastic Agents ,Breast Neoplasms ,Biology ,Chemical compounds ,Necrosis ,03 medical and health sciences ,Signs and Symptoms ,Diagnostic Medicine ,Cyclins ,Breast Cancer ,Organic compounds ,medicine ,Humans ,Protein kinase B ,PI3K/AKT/mTOR pathway ,Cell Proliferation ,Biochemistry, Genetics and Molecular Biology (all) ,Cell growth ,lcsh:R ,Cancers and Neoplasms ,Biology and Life Sciences ,Epithelial Cells ,HIV Protease Inhibitors ,Cell Biology ,biochemical phenomena, metabolism, and nutrition ,Oxidative Stress ,Biological Tissue ,030104 developmental biology ,Agricultural and Biological Sciences (all) ,Cancer cell ,lcsh:Q ,Reactive Oxygen Species - Abstract
The discovery of the anti-proliferative activity of nelfinavir in HIV-free models has encouraged its investigation as anticancer drug. Although the molecular mechanism by which nelfinavir exerts antitumor activity is still unknown, its effects have been related to Akt inhibition. Here we tested the effects of nelfinavir on cell proliferation, viability and death in two human breast cancer cell lines and in human normal primary breast cells. To identify the mechanism of action of nelfinavir in breast cancer, we evaluated the involvement of the Akt pathway as well as the effects of nelfinavir on reactive oxygen species (ROS) production and ROS-related enzymes activities. Nelfinavir reduced breast cancer cell viability by inducing apoptosis and necrosis, without affecting primary normal breast cells. The antitumor activity of nelfinavir was related to alterations of the cell redox state, coupled with an increase of intracellular ROS production limited to cancer cells. Nelfinavir treated tumor cells also displayed a downregulation of the Akt pathway due to disruption of the Akt-HSP90 complex, and subsequent degradation of Akt. These effects resulted to be ROS dependent, suggesting that ROS production is the primary step of nelfinavir anticancer activity. The analysis of ROS-producers and ROS-detoxifying enzymes revealed that nelfinavir-mediated ROS production was strictly linked to flavoenzymes activation. We demonstrated that ROS enhancement represents the main molecular mechanism required to induce cell death by nelfinavir in breast cancer cells, thus supporting the development of new and more potent oxidizing molecules for breast cancer therapy.
- Published
- 2016
6. Let's Twist Again: Nasolabial Turnover Flap for Full-thickness Aesthetical Nasal Ala Reconstruction.
- Author
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Schonauer F, D'Alessio M, Cavaliere A, Razzano S, and D'Angelo D
- Abstract
Background: The nasal ala has always been considered a difficult anatomical structure to restore, particularly when full-thickness reconstruction is needed. Although the forehead flap is considered the flap of choice, the nasolabial turnover flap, despite being a one-step surgical procedure, has been largely ignored for nasal ala reconstruction. We present our experience performing nasal ala full-thickness reconstruction with the nasolabial turnover flap, reporting on its advantages and comparing it with the most commonly used alternative techniques., Methods: Between 2017 and 2022, 48 patients presenting full-thickness defects of the nasal ala after skin cancer resection underwent reconstruction with a nasolabial turnover flap at two large regional plastic surgery units. Surgical technique was presented in detail, with particular attention in describing the complex three-dimensional movement of the flap., Results: All patients healed uneventfully, with good functional and cosmetic outcomes. No major complications were observed., Conclusions: The nasolabial turnover flap is a reliable and valuable option for achieving full-thickness nasal ala reconstruction. Satisfactory results in terms of function and cosmetic appearance can be obtained in a one-stage operation. Based upon our experience, the nasal turnover flap could be considered a viable reconstruction option, even for less-experienced surgeons., Competing Interests: The authors have no financial interest to declare in relation to the content of this article., (Copyright © 2024 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons.)
- Published
- 2024
- Full Text
- View/download PDF
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