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1. Effect of topical retinoic acids on the levels of collagen mRNA during the repair of UVB-induced dermal damage in the hairless mouse and the possible role of TGF-beta as a mediator.

Author

Kim HJ, Bogdan NJ, D'Agostaro LJ, Gold LI, and Bryce GF

Subjects
Administration, Topical, Animals, Female, Mice, Mice, Hairless, Skin drug effects, Skin metabolism, Tretinoin administration & dosage, Collagen genetics, RNA, Messenger analysis, Skin radiation effects, Transforming Growth Factor beta physiology, Tretinoin pharmacology, Ultraviolet Rays adverse effects
Abstract

Topically applied retinoic acids have been found to enhance the gene expression for collagen types I and III in the skin of UVB-irradiated hairless mice. Prior damage is required because the effect is not observed in the skin of age-matched, non-irradiated control animals. Immunochemical methods have shown an increase in TGF-beta 1 and, to a lesser extent, of TGF-beta 2 in the epidermis following retinoic acid treatment. There were no changes in mRNA levels for any of the isotypes of TGF-beta induced by retinoic acid treatment. This study suggests that TGF-beta may mediate the effect of retinoic acids on dermal repair through the stimulation of collagen gene expression.

Published
1992
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