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342 results on '"D'Addio, Francesca"'

1. Glucagon-like peptide 1 receptor is a T cell-negative costimulatory molecule

Author

Ben Nasr, Moufida, Usuelli, Vera, Dellepiane, Sergio, Seelam, Andy Joe, Fiorentino, Teresa Vanessa, D’Addio, Francesca, Fiorina, Emma, Xu, Cong, Xie, Yanan, Balasubramanian, Hari Baskar, Castillo-Leon, Eduardo, Loreggian, Lara, Maestroni, Anna, Assi, Emma, Loretelli, Cristian, Abdelsalam, Ahmed, El Essawy, Basset, Uccella, Silvia, Pastore, Ida, Lunati, Maria Elena, Sabiu, Gianmarco, Petrazzuolo, Adriana, Ducci, Giacomo, Sacco, Elena, Centofanti, Lucia, Venturini, Massimo, Mazzucchelli, Serena, Mattinzoli, Deborah, Ikehata, Masami, Castellano, Giuseppe, Visner, Gary, Kaifeng, Liu, Lee, Kang Mi, Wang, Zhimin, Corradi, Domenico, La Rosa, Stefano, Danese, Silvio, Yang, Jun, Markmann, James F., Zuccotti, Gian Vincenzo, Abdi, Reza, Folli, Franco, and Fiorina, Paolo

Published
2024
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3. Type 2 diabetes mellitus pharmacological remission with dapagliflozin plus oral semaglutide

Author

Lunati, Maria Elena, Cimino, Vincenzo, Bernasconi, Davide, Gandolfi, Alessandra, Morpurgo, Paola Silvia, Tinari, Camilla, Lazzaroni, Elisa, Baruffaldi, Laura, Muratori, Milena, Montefusco, Laura, Pastore, Ida, Rossi, Antonio, Franzetti, Ivano Giuseppe, Muratori, Fabrizio, Manfrini, Roberto, Disoteo, Olga Eugenia, Terranova, Rosa, Desenzani, Paolo, Girelli, Angela, Ghelardi, Renata, D’Addio, Francesca, Ben Nasr, Moufida, Berra, Cesare, Folli, Franco, Bucciarelli, Loredana, and Fiorina, Paolo

Published
2024
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5. Abnormalities of the oculomotor function in type 1 diabetes and diabetic neuropathy

Author

D’Addio, Francesca, Pastore, Ida, Loretelli, Cristian, Valderrama-Vasquez, Alessandro, Usuelli, Vera, Assi, Emma, Mameli, Chiara, Macedoni, Maddalena, Maestroni, Anna, Rossi, Antonio, Lunati, Maria Elena, Morpurgo, Paola Silvia, Gandolfi, Alessandra, Montefusco, Laura, Bolla, Andrea Mario, Ben Nasr, Moufida, Di Maggio, Stefania, Melzi, Lisa, Staurenghi, Giovanni, Secchi, Antonio, Bianchi Marzoli, Stefania, Zuccotti, Gianvincenzo, and Fiorina, Paolo

Published
2022
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7. eATP and autoimmune diabetes

Author

Loretelli, Cristian, Pastore, Ida, Lunati, Maria Elena, Abdelsalam, Ahmed, Usuelli, Vera, Assi, Emma, Fiorina, Emma, Loreggian, Lara, Balasubramanian, Hari Baskar, Xie, Yanan, Yang, Jun, El Essawy, Basset, Montefusco, Laura, D’Addio, Francesca, Ben Nasr, Moufida, and Fiorina, Paolo

Published
2023
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8. The IGFBP3/TMEM219 pathway regulates beta cell homeostasis

Author

D’Addio, Francesca, Maestroni, Anna, Assi, Emma, Ben Nasr, Moufida, Amabile, Giovanni, Usuelli, Vera, Loretelli, Cristian, Bertuzzi, Federico, Antonioli, Barbara, Cardarelli, Francesco, El Essawy, Basset, Solini, Anna, Gerling, Ivan C., Bianchi, Cristina, Becchi, Gabriella, Mazzucchelli, Serena, Corradi, Domenico, Fadini, Gian Paolo, Foschi, Diego, Markmann, James F., Orsi, Emanuela, Škrha, Jr, Jan, Camboni, Maria Gabriella, Abdi, Reza, James Shapiro, A. M., Folli, Franco, Ludvigsson, Johnny, Del Prato, Stefano, Zuccotti, Gianvincenzo, and Fiorina, Paolo

Published
2022
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9. Dapagliflozin acutely improves kidney function in type 2 diabetes mellitus. The PRECARE study

Author

Lazzaroni, Elisa, Lunati, Maria Elena, Montefusco, Laura, Pastore, Ida, Chebat, Enrica, Cimino, Vincenzo, Morpurgo, Paola Silvia, Muratori, Milena, Plebani, Laura, Bolla, Andrea, Rossi, Antonio, Vallone, Luciana, Gandolfi, Alessandra, Tinari, Camilla, D’Addio, Francesca, Nasr, Moufida Ben, Loretelli, Cristian, Scaranna, Cristiana, Bellante, Rosalia, Manfrini, Roberto, Muratori, Fabrizio, Franzetti, Ivano, Orsi, Emanuela, Gazzaruso, Carmine, Ghelardi, Renata, Desenzani, Paolo, Genovese, Stefano, Girelli, Angela, Folli, Franco, Berra, Cesare, and Fiorina, Paolo

Published
2022
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13. miR-21 antagonism reprograms macrophage metabolism and abrogates chronic allograft vasculopathy

Author

Usuelli, Vera, Ben Nasr, Moufida, D’Addio, Francesca, Liu, Kaifeng, Vergani, Andrea, El Essawy, Basset, Yang, Jun, Assi, Emma, Uehara, Mayuko, Rossi, Chiara, Solini, Anna, Capobianco, Annalisa, Rigamonti, Elena, Potena, Luciano, Venturini, Massimo, Sabatino, Mario, Bottarelli, Lorena, Ammirati, Enrico, Frigerio, Maria, Castillo-Leon, Eduardo, Maestroni, Anna, Azzoni, Cinzia, Loretelli, Cristian, Joe Seelam, Andy, Tai, Albert K., Pastore, Ida, Becchi, Gabriella, Corradi, Domenico, Visner, Gary A., Zuccotti, Gian V., Chau, Nelson B., Abdi, Reza, Pezzolesi, Marcus G., and Fiorina, Paolo

Published
2021
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15. Type 2 diabetes mellitus pharmacological remission with dapagliflozin plus oral semaglutide

Author

Lunati, Maria Elena, primary, Cimino, Vincenzo, additional, Bernasconi, Davide, additional, Gandolfi, Alessandra, additional, Morpurgo, Paola Silvia, additional, Tinari, Camilla, additional, Lazzaroni, Elisa, additional, Baruffaldi, Laura, additional, Muratori, Milena, additional, Montefusco, Laura, additional, Pastore, Ida, additional, Rossi, Antonio, additional, Franzetti, Ivano Giuseppe, additional, Muratori, Fabrizio, additional, Manfrini, Roberto, additional, Disoteo, Olga Eugenia, additional, Terranova, Rosa, additional, Desenzani, Paolo, additional, Girelli, Angela, additional, Ghelardi, Renata, additional, D’Addio, Francesca, additional, Ben Nasr, Moufida, additional, Berra, Cesare, additional, Folli, Franco, additional, Bucciarelli, Loredana, additional, and Fiorina, Paolo, additional

Published
2023
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16. The IL-8-CXCR1/2 axis contributes to diabetic kidney disease

Author

Loretelli, Cristian, Rocchio, Francesca, D'Addio, Francesca, Ben Nasr, Moufida, Castillo-Leon, Eduardo, Dellepiane, Sergio, Vergani, Andrea, Abdelsalam, Ahmed, Assi, Emma, Maestroni, Anna, Usuelli, Vera, Bassi, Roberto, Pastore, Ida, Yang, Jun, El Essawy, Basset, Elased, Khalid M., Fadini, Gian Paolo, Ippolito, Elio, Seelam, Andy Joe, Pezzolesi, Marcus, Corradi, Domenico, Zuccotti, Gian Vincenzo, Gallieni, Maurizio, Allegretti, Marcello, Niewczas, Monika Anna, and Fiorina, Paolo

Published
2021
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18. Acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection

Author

Montefusco, Laura, Ben Nasr, Moufida, D’Addio, Francesca, Loretelli, Cristian, Rossi, Antonio, Pastore, Ida, Daniele, Giuseppe, Abdelsalam, Ahmed, Maestroni, Anna, Dell’Acqua, Marco, Ippolito, Elio, Assi, Emma, Usuelli, Vera, Seelam, Andy Joe, Fiorina, Roberta Maria, Chebat, Enrica, Morpurgo, Paola, Lunati, Maria Elena, Bolla, Andrea Mario, Finzi, Giovanna, Abdi, Reza, Bonventre, Joseph V., Rusconi, Stefano, Riva, Agostino, Corradi, Domenico, Santus, Pierachille, Nebuloni, Manuela, Folli, Franco, Zuccotti, Gian Vincenzo, Galli, Massimo, and Fiorina, Paolo

Published
2021
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20. Embryonic stem cell extracts improve wound healing in diabetic mice

Author

Loretelli, Cristian, Ben Nasr, Moufida, Giatsidis, Giorgio, Bassi, Roberto, Lancerotto, Luca, D’Addio, Francesca, Valderrama-Vasquez, Alessandro, Scherer, Saja Sandra, Salvatore, Luca, Madaghiele, Marta, Abdelsalam, Ahmed, Ippolito, Elio, Assi, Emma, Usuelli, Vera, El Essawy, Basset, Sannino, Alessandro, Pietramaggiori, Giorgio, Zuccotti, Gian Vincenzo, Orgill, Dennis Paul, and Fiorina, Paolo

Published
2020
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22. TMEM219 regulates the transcription factor expression and proliferation of beta cells.

Author

D'Addio, Francesca, Assi, Emma, Maestroni, Anna, Rossi, Giada, Usuelli, Vera, Petrazzuolo, Adriana, Nardini, Marta, Loretelli, Cristian, Ben Nasr, Moufida, and Fiorina, Paolo

Subjects
PANCREATIC beta cells, ISLANDS of Langerhans, GENE expression, CELL proliferation, TRANSCRIPTION factors, TYPE 1 diabetes, CELL preservation
Abstract

Pancreatic beta cells replenishment is considered the next therapeutic option for type 1 diabetes; while stimulating endogenous beta cells proliferation is the "holy grail" for those patients with exhausted beta cell mass. Here we are demonstrating that the pro-apoptotic receptor TMEM219 is expressed in fetal pancreas, in beta cell precursors and in in vitro embryonic-derived endocrine progenitors. TMEM219 signaling negatively regulates beta cells at early stages and induces Caspase 8-mediated cell death. Pharmacological blockade of TMEM219 further rescued beta cell precursor and proliferation markers, and decreased cell death, both in islets and in in vitro-derived endocrine progenitors, allowing for beta cell preservation. While addressing the upstream controlling TMEM219 expression, we determined the TMEM219 miRNet; indeed, one of those miRNAs, miR-129-2, is highly expressed in human islets, particularly in patients at risk or with established type 1 diabetes. miR-129-2 mimic downregulated TMEM219 expression in islets, in in vitro embryonic-derived endocrine progenitors and in highly proliferating insulinoma-derived cells. Moreover, miR-129-2 inhibitor induced a TMEM219 overexpression in insulinoma-derived cells, which restored cell proliferation and functional markers, thus acting as endogenous regulator of TMEM219 expression. The TMEM219 upstream regulator miR129-2 controls the fate of beta cell precursors and may unleash their regenerative potentials to replenish beta cells in type 1 diabetes. [ABSTRACT FROM AUTHOR]

Published
2024
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26. P2X7R mutation disrupts the NLRP3-mediated Th program and predicts poor cardiac allograft outcomes

Author

D'Addio, Francesca, Vergani, Andrea, Potena, Luciano, Maestroni, Anna, Usuelli, Vera, Nasr, Moufida Ben, Bassi, Roberto, Tezza, Sara, Dellepiane, Sergio, Essawy, Basset El, Iascone, Maria, Iacovoni, Attilio, Borgese, Laura, Liu, Kaifeng, Visner, Gary, Dhe-Paganon, Sirano, Corradi, Domenico, Abdi, Reza, Starling, Randall C., Folli, Franco, Zuccotti, Gian Vincenzo, Sayegh, Mohamed H., Heeger, Peter S., Chandraker, Anil, Grigioni, Francesco, and Fiorina, Paolo

Subjects
Heart transplantation -- Usage -- Complications and side effects, Gene mutation -- Research, Cardiac patients -- Health aspects, Transcription factors -- Analysis, T cells -- Research, Health care industry
Abstract

Purinergic receptor-7 (P2X7R) signaling controls Th17 and Th1 generation/differentiation, while NOD-like receptor P3 (NLRP3) acts as a Th2 transcriptional factor. Here, we demonstrated the existence of a P2X7R/NLRP3 pathway in T cells that is dysregulated by a P2X7R intracellular region loss-of-function mutation, leading to NLRP3 displacement and to excessive Th17 generation due to abrogation of the NLRP3-mediated Th2 program. This ultimately resulted in poor outcomes in cardiac-transplanted patients carrying the mutant allele, who showed abnormal Th17 generation. Transient NLRP3 silencing in nonmutant T cells or overexpression in mutant T cells normalized the Th profile. Interestingly, IL-17 blockade reduced Th17 skewing of human T cells in vitro and abrogated the severe allograft vasculopathy and abnormal Th17 generation observed in preclinical models in which P2X7R was genetically deleted. This P2X7R intracellular region mutation thus impaired the modulatory effects of P2X7R on NLRP3 expression and function in T cells and led to NLRP3 dysregulation and Th17 skewing, delineating a high-risk group of cardiac-transplanted patients who may benefit from personalized therapy., Introduction Purinergic receptor-7 (P2X7R), primarily expressed on lymphocytes, senses adenosine 5'-triphosphate (ATP) (1) released extracellularly during cell damage (2, 3) and has been shown to regulate T cell activation (4-6). [...]

Published
2018
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27. GLP1R Strives T Cell Negative Costimulation Through a rRNA Gene Repressor Interactome

Author

Ben Nasr, Moufida, primary, Usuelli, Vera, additional, Dellepiane, Sergio, additional, Seelam, Andy Joe, additional, Fiorentino, Teresa Vanessa, additional, D’Addio, Francesca, additional, Fiorina, Emma, additional, Xu, Cong, additional, Xie, Yanan, additional, Balasubramanian, Hari Baskar, additional, Castillo-Leon, Eduardo, additional, Loreggian, Lara, additional, Maestroni, Anna, additional, Assi, Emma, additional, Loretelli, Cristian, additional, Abdelsalem, Ahmed, additional, El Essawy, Basset, additional, Uccella, Silvia, additional, Pastore, Ida, additional, Lunati, Maria Elena, additional, Sabiu, Gianmarco, additional, Petrazzuolo, Adriana, additional, Ducci, Giacomo, additional, Sacco, Elena, additional, Centofanti, Lucia, additional, Venturini, Massimo, additional, Mazzucchelli, Serena, additional, Mattinzoli, Deborah, additional, Ikehata, Masami, additional, Castellano, Giuseppe, additional, Visner, Gary, additional, Kaifeng, Liu, additional, Lee, Kang Mi, additional, Wang, Zhimin, additional, Corradi, Domenico, additional, La Rosa, Stefano, additional, Yang, Jun, additional, Markmann, James F., additional, Zuccotti, Gian Vincenzo, additional, Abdi, Reza, additional, Folli, Franco, additional, and Fiorina, Paolo, additional

Published
2023
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29. Targeting a novel apoptotic pathway in human disease.

Author

D'Addio, Francesca, Montefusco, Laura, Lunati, Maria Elena, Pastore, Ida, Assi, Emma, Petrazzuolo, Adriana, Marin, Virna, Bruckmann, Chiara, and Fiorina, Paolo

Subjects
*INSULIN-like growth factor-binding proteins, *ISLANDS of Langerhans, *PANCREAS, *DEATH receptors, *CELL death
Abstract

Apoptotic pathways have always been regarded as a key‐player in preserving tissue and organ homeostasis. Excessive activation or resistance to activation of cell death signaling may indeed be responsible for several mechanisms of disease, including malignancy and chronic degenerative diseases. Therefore, targeting apoptotic factors gained more and more attention in the scientific community and novel strategies emerged aimed at selectively blocking or stimulating cell death signaling. This is also the case for the TMEM219 death receptor, which is activated by a circulating ligand, the Insulin‐like growth factor binding protein 3 (IGFBP3) and induces a caspase‐8‐dependent apoptosis of the target cells. Interestingly, stimulation of the IGFBP3/TMEM219 axis exerts an anti‐proliferative effect, while blockade of the TMEM219 deleterious signal protects TMEM219‐expressing cells of the endocrine pancreas, lung, and intestine from damage and death. Here, we summarize the most updated reports on the role of the IGFBP3/TMEM219 apoptotic axis in disease conditions, including intestinal disorders and diabetes, and we describe the advancements in designing and testing novel TMEM219‐based targeting approaches in emerging potential clinical applications. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Neuroblastoma suppressor of tumorigenicity 1 is a circulating protein associated with progression to end-stage kidney disease in diabetes

Author

Kobayashi, Hiroki, primary, Looker, Helen C., additional, Satake, Eiichiro, additional, D’Addio, Francesca, additional, Wilson, Jonathan M., additional, Saulnier, Pierre Jean, additional, Md Dom, Zaipul I., additional, O’Neil, Kristina, additional, Ihara, Katsuhito, additional, Krolewski, Bozena, additional, Badger, Hannah S., additional, Petrazzuolo, Adriana, additional, Corradi, Domenico, additional, Galecki, Andrzej, additional, Wilson, Parker C., additional, Najafian, Behzad, additional, Mauer, Michael, additional, Niewczas, Monika A., additional, Doria, Alessandro, additional, Humphreys, Benjamin D., additional, Duffin, Kevin L., additional, Fiorina, Paolo, additional, Nelson, Robert G., additional, and Krolewski, Andrzej S., additional

Published
2022
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35. The anti-inflammatory and immunological properties of GLP-1 Receptor Agonists

Author

Bendotti, Giulia, primary, Montefusco, Laura, additional, Lunati, Maria Elena, additional, Usuelli, Vera, additional, Pastore, Ida, additional, Lazzaroni, Elisa, additional, Assi, Emma, additional, Seelam, Andy Joe, additional, El Essawy, Basset, additional, Jang, Jun, additional, Loretelli, Cristian, additional, D’Addio, Francesca, additional, Berra, Cesare, additional, Ben Nasr, Moufida, additional, Zuccotti, GianVincenzo, additional, and Fiorina, Paolo, additional

Published
2022
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36. Immunogenicity and Safety of SARS-CoV-2 mRNA Vaccines in a Cohort of Patients With Type 1 Diabetes

Author

D’Addio, Francesca, primary, Sabiu, Gianmarco, additional, Usuelli, Vera, additional, Assi, Emma, additional, Abdelsalam, Ahmed, additional, Maestroni, Anna, additional, Seelam, Andy Joe, additional, Ben Nasr, Moufida, additional, Loretelli, Cristian, additional, Mileto, Davide, additional, Rossi, Giada, additional, Pastore, Ida, additional, Montefusco, Laura, additional, Morpurgo, Paola S., additional, Plebani, Laura, additional, Rossi, Antonio, additional, Chebat, Enrica, additional, Bolla, Andrea M., additional, Lunati, Maria Elena, additional, Mameli, Chiara, additional, Macedoni, Maddalena, additional, Antinori, Spinello, additional, Rusconi, Stefano, additional, Gallieni, Maurizio, additional, Berra, Cesare, additional, Folli, Franco, additional, Galli, Massimo, additional, Gismondo, Maria Rita, additional, Zuccotti, Gianvincenzo, additional, and Fiorina, Paolo, additional

Published
2022
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37. Inflammation and vascular dysfunction: The negative synergistic combination of diabetes and COVID‐19

Author

Bolla, Andrea Mario, primary, Loretelli, Cristian, additional, Montefusco, Laura, additional, Finzi, Giovanna, additional, Abdi, Reza, additional, Ben Nasr, Moufida, additional, Lunati, Maria Elena, additional, Pastore, Ida, additional, Bonventre, Joseph V., additional, Nebuloni, Manuela, additional, Rusconi, Stefano, additional, Santus, Pierachille, additional, Zuccotti, Gianvincenzo, additional, Galli, Massimo, additional, D’Addio, Francesca, additional, and Fiorina, Paolo, additional

Published
2022
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39. Indirect and Direct Effects of SARS-CoV-2 on Human Pancreatic Islets

Author

Nasr, Moufida Ben, primary, D’Addio, Francesca, primary, Montefusco, Laura, primary, Usuelli, Vera, primary, Loretelli, Cristian, primary, Rossi, Antonio, primary, Pastore, Ida, primary, Abdelsalam, Ahmed, primary, Maestroni, Anna, primary, Dell’Acqua, Marco, primary, Ippolito, Elio, primary, Assi, Emma, primary, Seelam, Andy Joe, primary, Fiorina, Roberta Maria, primary, Chebat, Enrica, primary, Morpurgo, Paola, primary, Lunati, Maria Elena, primary, Bolla, Andrea Mario, primary, Abdi, Reza, primary, Bonventre, Joseph V., primary, Rusconi, Stefano, primary, Riva, Agostino, primary, Corradi, Domenico, primary, Santus, Pierachille, primary, Clark, Pamela, primary, Nebuloni, Manuela, primary, Baldi, Gabriella, primary, Finzi, Giovanna, primary, Folli, Franco, primary, Zuccotti, Gian Vincenzo, primary, Galli, Massimo, primary, Herold, Kevan C., primary, and Fiorina, Paolo, primary

Published
2022
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40. Indirect and Direct Effects of SARS-CoV-2 on Human Pancreatic Islets

Author

Ben Nasr, Moufida, primary, D’Addio, Francesca, additional, Montefusco, Laura, additional, Usuelli, Vera, additional, Loretelli, Cristian, additional, Rossi, Antonio, additional, Pastore, Ida, additional, Abdelsalam, Ahmed, additional, Maestroni, Anna, additional, Dell’Acqua, Marco, additional, Ippolito, Elio, additional, Assi, Emma, additional, Seelam, Andy Joe, additional, Fiorina, Roberta Maria, additional, Chebat, Enrica, additional, Morpurgo, Paola, additional, Lunati, Maria Elena, additional, Bolla, Andrea Mario, additional, Abdi, Reza, additional, Bonventre, Joseph V., additional, Rusconi, Stefano, additional, Riva, Agostino, additional, Corradi, Domenico, additional, Santus, Pierachille, additional, Clark, Pamela, additional, Nebuloni, Manuela, additional, Baldi, Gabriella, additional, Finzi, Giovanna, additional, Folli, Franco, additional, Zuccotti, Gian Vincenzo, additional, Galli, Massimo, additional, Herold, Kevan C., additional, and Fiorina, Paolo, additional

Published
2022
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44. PD-1 blockade counteracts post–COVID-19 immune abnormalities and stimulates the anti–SARS-CoV-2 immune response

Author

Loretelli, Cristian, primary, Abdelsalam, Ahmed, additional, D’Addio, Francesca, additional, Ben Nasr, Moufida, additional, Assi, Emma, additional, Usuelli, Vera, additional, Maestroni, Anna, additional, Seelam, Andy Joe, additional, Ippolito, Elio, additional, Di Maggio, Stefania, additional, Loreggian, Lara, additional, Radovanovic, Dejan, additional, Vanetti, Claudia, additional, Yang, Jun, additional, El Essawy, Basset, additional, Rossi, Antonio, additional, Pastore, Ida, additional, Montefusco, Laura, additional, Lunati, Maria Elena, additional, Bolla, Andrea M., additional, Biasin, Mara, additional, Antinori, Spinello, additional, Santus, Pierachille, additional, Riva, Agostino, additional, Zuccotti, Gian Vincenzo, additional, Galli, Massimo, additional, Rusconi, Stefano, additional, and Fiorina, Paolo, additional

Published
2021
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45. List of contributors

Author

Abell, Thomas, Acosta, Camilo J., Adadey, Samuel Mawuli, Anaya, Juan-Manuel, Annibale, Bruno, Antonini, Simone, Aqeel, Faten, Arepalli, Sruthi, Assassi, Shervin, Babushok, Daria V., Barkin, Jodie A., Bartalena, Luigi, Ben Nasr, Moufida, Berentsen, Sigbjørn, Betterle, Corrado, Birtolo, Maria Francesca, Bisarya, Pooja Nikki, Blüml, Stephan, Bonomi, Marco, Bowlus, Christopher L., Brassard, Alain, Brusch, Anna, Burrone, Marco, Carrillo-Bayona, Jorge Alberto, Casciola-Rosen, Livia, Caturegli, Patrizio, Chang, Christopher, Chatzis, Loukas, Chaves, Juan José, Chen, Dhruti P., Chen, Jingjing, Chen, Saijuan, Cheng, Wenyan, Chhabra, Garvit, Choi, Jamie H., Cianferotti, Luisella, Crowell, Eric, Cuda, Carla M., Davidson, Anne, Deane, Sean, del Carmen Moleon, Maria, Di Dalmazi, Giulia, Dilaghi, Emanuele, Dixon Johns, James, Doost, Mohammad Saffari, Dyke, Jason, D’Addio, Francesca, D’Cruz, David P., Falk, Ronald J., Farina, Antonio, Fattizzo, Bruno, Fernandez-Carbonell, Cristina, Fiorina, Paolo, Flanagan, Eoin P., Franzen, Daniel P., Frederiksen, Henrik, Free, Meghan E., Frejo, Lidia, Fung, Maxwell A., Gaffney, Patrick M., Galindo, Javier Leonardo, Gallo, Daniela, Gately, Ursula, Geetha, Duvuru, Gershwin, M. Eric, Goldbach-Mansky, Raphaela, Goronzy, Jörg J., Goules, Andreas V., Gudjonsson, Johann E., Guilherme, Luiza, Guo, Weinan, Hajj-Ali, Rula A., Hamburger, Nicole, He, Liting, Herrán, María, Hoa, Michael, Honnorat, Jérôme, Hu, Qingjie, Hu, Yue, Husebye, Eystein S., Ippolito, Silvia, James, Eddie A., James, Judith A., Jennette, J. Charles, Jian, Zhe, Jiang, Ying, Kaklamanos, Aimilios, Kalil, Jorge, Kaminski, Henry J., Kammeyer, Ryan, Kaya, Ziya, Kelly, Jennifer A., Khakoo, Nidah Shabbir, Khoury, Samia J., Kolios, Antonios G.A., Königs, Christoph, Kopplin, Laura J., Krupp, Lauren B., Kuker, Russ, Kwapnoski, Zachary, Kyttaris, Vasileios C., La Cava, Antonio, Lahner, Edith, Lania, Andrea G., Lehmann, Helmar C., Levy, Cynthia, Li, Chunying, Li, Kun, Li, Shuli, Li, Xiangqian, Liu, Hui, Liu, Ling, Liu, Yudong, Lleo, Ana, Long, Hai, Lopez-Escamez, Jose A., Lu, Qianjin, Lunati, Maria Elena, Lunn, Michael P.T., Lupi, Isabella, Malattia, Clara, Maletic-Savatic, Mirjana, Marietta, Eric V., Martin, Cole, Martini, Alberto, Mastaglia, Frank, Mathur, Prateek, Mazziotti, Gherardo, McDonald, Benjamin, Mehta, Neesurg S., Mieli-Vergani, Giorgina, Milano, Reza V., Morel, Laurence, Moss, Brandon, Moussa, Kareem, Murray, Joseph A., Naing, LeYu, Needham, Merrilee, Nelson, Andrew J., Nilsson, Jakob, O'Neill, Kimberly A., Ochoa, Jorge R., Öztosun, Gülşen, Pan, Meng, Paramalingam, Shereen, Pathak, Shresh, Pei, Chenchen, Perl, Andras, Perlman, Harris, Persani, Luca, Pillai, Shiv, Piquet, Amanda L., Poddubnyy, Denis, Polo, Fernando, Presotto, Fabio, Rabb, Hamid, Radin, Massimo, Rochat, Pete, Rodolfi, Stefano, Rojas, Manuel, Rosen, Antony, Rossetti, Raffaella, Rubin, David T., Saab, Georges, Sabbadin, Chiara, Salbach, Christian, Schreiber, Karen, Sciascia, Savino, Sheikh, Kazim A., Shen, Yang, Shusko, Alexander R., Sieper, Joachim, Smilek, Dawn Elaine, Smith, Kenneth, Smolen, Josef S., Sorkhabi, Sharareh Yousefpour, Stocker, Abigail, Stone, John H., Stroikova, Vera, Sun, Yonghu, Syrbe, Uta, Tanda, Maria Laura, Taubenslag, Kenneth J., Terziroli Beretta-Piccoli, Benedetta, Tessneer, Kandice L., Thakolwiboon, Smathorn, Tian, Jingru, Tiniakou, Eleni, Titulaer, Maarten J., Tsui, Edmund, Tzioufas, Athanasios G., Vambutas, Andrea, van Steenhoven, Robin W., Varga, John, Vergani, Diego, Villagrán-García, Macarena, Vondenberg, Jaime A., Vora, Paras, Wagner, Catriona A., Wang, Gang, Wang, Jingying, Wang, Min, Wang, Xin, Weinstein, Jessica E., Weyand, Cornelia M., Xin, Yue, Xing, Enze, Yao, Xu, Yu, Cong, Zhang, Furen, Zhang, Jianzhong, Zhang, Xuan, Zhou, Cheng, Zhu, Haiqin, Zhu, Hong, Zinger, Adar, and Zuo, Xiaoxia

Published
2024
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47. Anti-diabetic drugs and weight loss in patients with type 2 diabetes

Author

Lazzaroni, Elisa, primary, Ben Nasr, Moufida, additional, Loretelli, Cristian, additional, Pastore, Ida, additional, Plebani, Laura, additional, Lunati, Maria Elena, additional, Vallone, Luciana, additional, Bolla, Andrea Mario, additional, Rossi, Antonio, additional, Montefusco, Laura, additional, Ippolito, Elio, additional, Berra, Cesare, additional, D’Addio, Francesca, additional, Zuccotti, Gian Vincenzo, additional, and Fiorina, Paolo, additional

Published
2021
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48. Abnormalities of the oculomotor function in type 1 diabetes and diabetic neuropathy.

Author

D'Addio, Francesca, Pastore, Ida, Loretelli, Cristian, Valderrama-Vasquez, Alessandro, Usuelli, Vera, Assi, Emma, Mameli, Chiara, Macedoni, Maddalena, Maestroni, Anna, Rossi, Antonio, Lunati, Maria Elena, Morpurgo, Paola Silvia, Gandolfi, Alessandra, Montefusco, Laura, Bolla, Andrea Mario, Ben Nasr, Moufida, Di Maggio, Stefania, Melzi, Lisa, Staurenghi, Giovanni, and Secchi, Antonio

Subjects
*TYPE 1 diabetes, *DIABETIC neuropathies, *ARTIFICIAL pancreases, *EYE tracking, *EYE movements, *PEOPLE with diabetes, *HUMAN abnormalities
Abstract

Aims: Abnormalities in the oculomotor system may represent an early sign of diabetic neuropathy and are currently poorly studied. We designed an eye-tracking-based test to evaluate oculomotor function in patients with type 1 diabetes. Methods: We used the SRLab—Tobii TX300 Eye tracker®, an eye-tracking device, coupled with software that we developed to test abnormalities in the oculomotor system. The software consists of a series of eye-tracking tasks divided into 4 classes of parameters (Resistance, Wideness, Pursuit and Velocity) to evaluate both smooth and saccadic movement in different directions. We analyzed the oculomotor system in 34 healthy volunteers and in 34 patients with long-standing type 1 diabetes. Results: Among the 474 parameters analyzed with the eye-tracking-based system, 11% were significantly altered in patients with type 1 diabetes (p < 0.05), with a higher proportion of abnormalities observed in the Wideness (24%) and Resistance (10%) parameters. Patients with type 1 diabetes without diabetic neuropathy showed more frequently anomalous measurements in the Resistance class (p = 0.02). The classes of Velocity and Pursuit were less frequently altered in patients with type 1 diabetes as compared to healthy subjects, with anomalous measurements mainly observed in patients with diabetic neuropathy. Conclusions: Abnormalities in oculomotor system function can be detected in patients with type 1 diabetes using a novel eye-tracking-based test. A larger cohort study may further determine thresholds of normality and validate whether eye-tracking can be used to non-invasively characterize early signs of diabetic neuropathy. Trial: NCT04608890. [ABSTRACT FROM AUTHOR]

Published
2022
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49. Hematopoietic Stem Cells in Type 1 Diabetes

Author

Pastore, Ida, primary, Assi, Emma, additional, Ben Nasr, Moufida, additional, Bolla, Andrea Mario, additional, Maestroni, Anna, additional, Usuelli, Vera, additional, Loretelli, Cristian, additional, Seelam, Andy Joe, additional, Abdelsalam, Ahmed, additional, Zuccotti, Gian Vincenzo, additional, D’Addio, Francesca, additional, and Fiorina, Paolo, additional

Published
2021
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