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217 results on '"D'Abramo, Alessandra"'

1. Role of Direct Sexual Contact in Human Transmission of Monkeypox Virus, Italy

Author

Sberna, Giuseppe, Rozera, Gabriella, Minosse, Claudia, Bordi, Licia, Mazzotta, Valentina, D'Abramo, Alessandra, Girardi, Enrico, Antinori, Andrea, Maggi, Fabrizio, and Lalle, Eleonora

Subjects
Human monkeypox -- Genetic aspects -- Diagnosis -- Care and treatment, Sexual intercourse -- Health aspects, Messenger RNA -- Health aspects, Disease transmission -- Genetic aspects, Health
Abstract

Monkeypox virus (MPXV) is the etiologic agent of zoonotic mpox disease. Although the virus was first discovered in colonies of monkeys kept for research in 1958, MPXV is mainly transmitted [...]

Published
2024
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7. Immunological signature in human cases of monkeypox infection in 2022 outbreak: an observational study

Author

Agrati, Chiara, Cossarizza, Andrea, Mazzotta, Valentina, Grassi, Germana, Casetti, Rita, De Biasi, Sara, Pinnetti, Carmela, Gili, Simona, Mondi, Annalisa, Cristofanelli, Flavia, Lo Tartaro, Domenico, Notari, Stefania, Maffongelli, Gaetano, Gagliardini, Roberta, Gibellini, Lara, Aguglia, Camilla, Lanini, Simone, D'Abramo, Alessandra, Matusali, Giulia, Fontana, Carla, Nicastri, Emanuele, Maggi, Fabrizio, Girardi, Enrico, Vaia, Francesco, and Antinori, Andrea

Published
2023
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8. The unmet need for COVID-19 treatment in immunocompromised patients

Author

D’Abramo Alessandra, Vita Serena, and Nicastri Emanuele

Subjects
Immunocompromised patients, Severe and/or prolonged COVID-19, Passive immunotherapy, Antiviral therapy, Combined therapy, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Immunocompromised (IC) patients are at increased risk of severe and/or prolonged COVID-19. Main text The recent study by Scaglione et al., addresses the issue of IC outpatients with SARS-CoV-2 infection. Authors describe the real-life use of SARS-CoV-2 antivirals and/or monoclonal antibodies and the clinical benefit in high-risk COVID-19 patients. The study supports the use of early combination therapy in a subgroup of extremely high risk patients, and considers the combined strategy as a gold standard regimen to both increase the effectiveness of early treatment, especially in IC individuals, and, reduce the emergence of SARS-CoV-2 escape mutants. Conclusion A tailored and standardised therapeutic approach in case of IC out and inpatients with SARS-CoV-2 infection is needed.

Published
2022
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9. Autochthonous Dengue Fever in 2 Patients, Rome, Italy

Author

Vita, Serena, Bordi, Licia, Sberna, Giuseppe, Caputi, Priscilla, Lapa, Daniele, Corpolongo, Angela, Mija, Cosmina, D'Abramo, Alessandra, Maggi, Fabrizio, Vairo, Francesco, Specchiarello, Eliana, Girardi, Enrico, Lalle, Eleonora, and Nicastri, Emanuele

Subjects
Aedes albopictus -- Health aspects, Dengue -- Health aspects, Infection -- Health aspects, Travelers -- Health aspects, Disease transmission -- Health aspects, Health
Abstract

Dengue virus (DENV) infection is the most prevalent arthropodborne viral disease in humans, caused by 4 DENV serotypes widely spread in tropical and subtropical regions and transmitted mainly by Aedes [...]

Published
2024

10. Infectious Toscana Virus in Seminal Fluid of Young Man Returning from Elba Island, Italy

Author

Matusali, Giulia, D'Abramo, Alessandra, Terrosi, Chiara, Carletti, Fabrizio, Colavita, Francesca, Vairo, Francesco, Savellini, Gianni Gori, Gandolfo, Claudia, Anichini, Gabriele, Lalle, Eleonora, Bordi, Licia, Corpolongo, Angela, Maritti, Micaela, Marchioni, Luisa, Capobianchi, Maria Rosaria, Castilletti, Concetta, Cusi, Maria Grazia, and Nicastri, Emanuele

Subjects
Semen -- Case studies -- Health aspects, Bunyaviruses -- Case studies -- Identification and classification, RNA virus infections -- Case studies -- Risk factors -- Diagnosis, Viral meningitis -- Case studies -- Risk factors -- Diagnosis, Health
Abstract

Toscana virus (TOSV) is an arthropodborne virus, belonging to the genus Phlebovirus, that was first isolated in Monte Argentario in 1971 from the sand flies Phlebotomus perniciosus and P. perfiliewi [...]

Published
2022
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11. Risk and predictive factors of prolonged viral RNA shedding in upper respiratory specimens in a large cohort of COVID-19 patients admitted to an Italian reference hospital

Author

Abbonizio, Maria Alessandra, Abdeddaim, Amina, Agostini, Elisabetta, Agrati, Chiara, Albarello, Fabrizio, Amadei, Gioia, Amendola, Alessandra, Antinori, Andrea, Antonica, Maria Assunta, Antonini, Mario, Bartoli, Tommaso Ascoli, Baldini, Francesco, Barbaro, Raffaella, Bartolini, Barbara, Bellagamba, Rita, Benigni, Martina, Bevilacqua, Nazario, Biava, Gianluigi, Bibas, Michele, Bordi, Licia, Bordoni, Veronica, Boumis, Evangelo, Branca, Marta, Buonomo, Rosanna, Busso, Donatella, Camici, Marta, Campioni, Paolo, Canichella, Flaminia, Capobianchi, Maria Rosaria, Capone, Alessandro, Caporale, Cinzia, Caraffa, Emanuela, Caravella, Ilaria, Carletti, Fabrizio, Castilletti, Concetta, Cataldo, Adriana, Cerilli, Stefano, Cerva, Carlotta, Chiappini, Roberta, Chinello, Pierangelo, Cianfarani, Maria Assunta, Ciaralli, Carmine, Cimaglia, Claudia, Cinicola, Nicola, Ciotti, Veronica, Cicalini, Stefania, Colavita, Francesca, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, De Angelis, Alessia, De Angelis, Giada, De Palo, Maria Grazia, De Zottis, Federico, Di Bari, Virginia, Di Lorenzo, Rachele, Di Stefano, Federica, D’Offizi, Gianpiero, Donno, Davide, Evangelista, Francesca, Faraglia, Francesca, Farina, Anna, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Fusetti, Matteo, Galati, Vincenzo, Gagliardini, Roberta, Gallì, Paola, Garotto, Gabriele, Gaviano, Ilaria, Tekle, Saba Gebremeskel, Giancola, Maria Letizia, Giansante, Filippo, Giombini, Emanuela, Granata, Guido, Greci, Maria Cristina, Grilli, Elisabetta, Grisetti, Susanna, Gualano, Gina, Iacomi, Fabio, Iaconi, Marta, Iannicelli, Giuseppina, Inversi, Carlo, Ippolito, Giuseppe, Lalle, Eleonora, Lamanna, Maria Elena, Lanini, Simone, Lapa, Daniele, Lepore, Luciana, Libertone, Raffaella, Lionetti, Raffaella, Liuzzi, Giuseppina, Loiacono, Laura, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Maffongelli, Gaetano, Marani, Alessandra, Marchioni, Luisa, Mariano, Andrea, Marini, Maria Cristina, Maritti, Micaela, Mastrobattista, Annelisa, Mastrorosa, Ilaria, Matusali, Giulia, Mazzotta, Valentina, Mencarini, Paola, Meschi, Silvia, Messina, Francesco, Micarelli, Sibiana, Mogavero, Giulia, Mondi, Annalisa, Montalbano, Marzia, Montaldo, Chiara, Mosti, Silvia, Murachelli, Silvia, Musso, Maria, Nardi, Michela, Navarra, Assunta, Nicastri, Emanuele, Nocioni, Martina, Noto, Pasquale, Noto, Roberto, Oliva, Alessandra, Onnis, Ilaria, Ottou, Sandrine, Palazzolo, Claudia, Pallini, Emanuele, Palmieri, Fabrizio, Palombi, Giulio, Pareo, Carlo, Passeri, Virgilio, Pelliccioni, Federico, Penna, Giovanna, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pinnetti, Carmela, Pisciotta, Maria, Piselli, Pierluca, Pittalis, Silvia, Pontarelli, Agostina, Proietti, Costanza, Puro, Vincenzo, Ramazzini, Paolo Migliorisi, Rianda, Alessia, Rinonapoli, Gabriele, Rosati, Silvia, Rubino, Dorotea, Rueca, Martina, Ruggeri, Alberto, Sacchi, Alessandra, Sampaolesi, Alessandro, Sanasi, Francesco, Santagata, Carmen, Scarabello, Alessandra, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Scorzolini, Laura, Stazi, Giulia, Strano, Giacomo, Taglietti, Fabrizio, Taibi, Chiara, Taloni, Giorgia, Nardi, Tetaj, Tonnarini, Roberto, Topino, Simone, Tozzi, Martina, Vaia, Francesco, Vairo, Francesco, Valli, Maria Beatrice, Vergori, Alessandra, Vincenzi, Laura, Visco-Comandini, Ubaldo, Vita, Serena, Vittozzi, Pietro, Zaccarelli, Mauro, Zanetti, Antonella, Zito, Sara, Lorenzini, Patrizia, Di Gennaro, Francesco, and Girardi, Enrico

Published
2021
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12. Real World Use of Tixagevimab/Cilgavimab Pre-Exposure Prophylaxis of COVID-19 in Immunocompromised Individuals: Data from the OCTOPUS Study.

Author

Vergori, Alessandra, Matusali, Giulia, Cimini, Eleonora, Bordi, Licia, Borrelli, Paola, Lanini, Simone, Palazzi, Roberta, Paulicelli, Jessica, Mariotti, Davide, Mazzotta, Valentina, Notari, Stefania, Casetti, Rita, Francalancia, Massimo, Rosati, Silvia, D'Abramo, Alessandra, Mija, Cosmina, Mencarini, Paola, Milozzi, Eugenia, Caraffa, Emanuela, and Sica, Simona

Subjects
COVID-19 pandemic, SARS virus, BREAKTHROUGH infections, BLOOD diseases, HUMORAL immunity
Abstract

Objective. We aimed to report the real-world use and outcomes over time in immunocompromised individuals receiving tixagevimab/cilgavimab (T/C) pre-exposure prophylaxis (PrEP). Methods. This observational study included participants who received T/C PrEP, categorized into three groups: (i) No COVID-19 (NoC), i.e., participants who never had COVID-19; (ii) Hybrids (H), i.e., participants who had COVID-19 before PrEP; and (iii) Break-through Infections (BTIs), i.e., participants who had COVID-19 after PrEP. The study measured several immune markers at the administration of T/C (T0) at 3 (T1), 6 (T2), and 9 (T3) months afterward. These markers included: anti-receptor-binding domain (RBD) IgG antibodies; BA.5-neutralizing antibodies (nAbs); mucosal IgG; and T cell immunity. The incidence rate ratios for BTIs were analyzed using a Poisson regression model. Results. A total of 231 participants with a median age of 63 years (IQR 54.0–73.0). were included. Among these, 84% had hematological diseases and received a median of three vaccine doses. N = 72 participants belonged to the NoC group, N = 103 to the H group, and n = 56 to the BTI group (24%), with most BTIs being mild/moderate. The incidence rate (IR) of BTIs was 4.2 per 100 patient-months (95% CI 3.2–5.4), with no associated risk factors identified. There was a significant increase in anti-RBD IgG levels 3 months after the T/C administration in all groups, followed by a decline at 6 months, whereas at the same time points, geometric mean titers (GMTs) of anti-BA.5 nAbs were low for all groups and were around or below the detection threshold. No significant changes were observed in IFN-γ levels. The mucosal immune response was observed only 3 months after the PrEP administration. Conclusion. We provided a real-world experience model on the clinical efficacy of T/C PrEP in preventing severe COVID-19 during the Omicron wave through a comprehensive virological and immunological study. While waiting for the arrival of new monoclonal antibodies that can effectively neutralize the most recent variants, T/C PrEP remains the only viable strategy in the available armamentarium today to prevent COVID-19 complications in an extremely fragile population with suboptimal immune responses to COVID-19 vaccines. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Saliva Is a Sensitive and Accessible Sample Both for SARS-CoV-2 Detection and for the Evaluation of Treatment Effectiveness in Follow-Up Studies.

Author

Lalle, Eleonora, Mazzotta, Valentina, Sberna, Giuseppe, Fabeni, Lavinia, Garbuglia, Anna Rosa, Mastrorosa, Ilaria, D'Abramo, Alessandra, Nicastri, Emanuele, Girardi, Enrico, Antinori, Andrea, Maggi, Fabrizio, and Bordi, Licia

Subjects
TREATMENT effectiveness, SALIVA analysis, DRUG efficacy, COVID-19 testing, SALIVA
Abstract

Despite emerging evidence indicating that molecular SARS-CoV-2 tests performed on saliva have diagnostic sensitivity and specificity comparable to those observed with nasopharyngeal swabs (NPSs), most in vivo follow-up studies on the efficacy of drugs against SARS-CoV-2 have been performed on NPSs, not considering saliva as a possible alternative matrix. For this reason, in this study, we used, in parallel, saliva and NPS samples for the detection of SARS-CoV-2 by real-time RT-PCR in patients receiving Tixagevimab/Cilgavimab, Nirmatrelvir/Ritonavir, or Sotrovimab as a treatment against SARS-CoV-2. Our results showed a good correlation between the NPS and saliva samples for each drug; moreover, comparable changes in the cycle threshold (Ct) levels in saliva and NPSs were observed both 7 days and 30 days after treatment, thus confirming that the saliva represents a good matrix for in vivo follow-up studies verifying the effectiveness of treatments against SARS-CoV-2. [ABSTRACT FROM AUTHOR]

Published
2024
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14. 2019-novel Coronavirus severe adult respiratory distress syndrome in two cases in Italy: An uncommon radiological presentation

Author

Abbonizio, Maria Alessandra, Agrati, Chiara, Albarello, Fabrizio, Amadei, Gioia, Amendola, Alessandra, Antonini, Mario, Barbaro, Raffaella, Bartolini, Barbara, Benigni, Martina, Bevilacqua, Nazario, Bordi, Licia, Bordoni, Veronica, Branca, Marta, Campioni, Paolo, Capobianchi, Maria Rosaria, Caporale, Cinzia, Caravella, Ilaria, Carletti, Fabrizio, Castilletti, Concetta, Chiappini, Roberta, Ciaralli, Carmine, Colavita, Francesca, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, Angelis, Alessia De, Angelis, Giada De, Lorenzo, Rachele Di, Stefano, Federica Di, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Gallì, Paola, Garotto, Gabriele, Giancola, Maria Letizia, Giansante, Filippo, Giombini, Emanuela, Greci, Maria Cristina, Ippolito, Giuseppe, Lalle, Eleonora, Lanini, Simone, Lapa, Daniele, Lepore, Luciana, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Marani, Alessandra, Marchioni, Luisa, Mariano, Andrea, Marini, Maria Cristina, Maritti, Micaela, Matusali, Giulia, Meschi, Silvia, Montaldo, Francesco Messina Chiara, Murachelli, Silvia, Nicastri, Emanuele, Noto, Roberto, Palazzolo, Claudia, Pallini, Emanuele, Passeri, Virgilio, Pelliccioni, Federico, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pisciotta, Maria, Pittalis, Silvia, Proietti, Costanza, Puro, Vincenzo, Rinonapoli, Gabriele, Rueca, Martina, Sacchi, Alessandra, Sanasi, Francesco, Santagata, Carmen, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Scorzolini, Laura, Stazi, Giulia, Vaia, Francesco, Vairo, Francesco, Valli, Maria Beatrice, Di Stefano, Federica, Eskild, Petersen, and Zumla, Alimuddin

Published
2020
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16. Combined antiviral therapy as effective and feasible option in allogenic hematopoietic stem cell transplantation during SARS-COV-2 infection: a case report

Author

Vita, Serena, primary, D’Abramo, Alessandra, additional, Coppola, Andrea, additional, Farroni, Chiara, additional, Iori, Anna Paola, additional, Faraglia, Francesca, additional, Sette, Alessandro, additional, Grifoni, Alba, additional, Lindestam Arlehamn, Cecilia, additional, Bibas, Michele, additional, Goletti, Delia, additional, and Nicastri, Emanuele, additional

Published
2024
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18. Humoral- and T-Cell–Specific Immune Responses to SARS-CoV-2 mRNA Vaccination in Patients With MS Using Different Disease-Modifying Therapies

Author

Tortorella, Carla, Aiello, Alessandra, Gasperini, Claudio, Agrati, Chiara, Castilletti, Concetta, Ruggieri, Serena, Meschi, Silvia, Matusali, Giulia, Colavita, Francesca, Farroni, Chiara, Cuzzi, Gilda, Cimini, Eleonora, Tartaglia, Eleonora, Vanini, Valentina, Prosperini, Luca, Haggiag, Shalom, Galgani, Simona, Quartuccio, Maria Esmeralda, Salmi, Andrea, Repele, Federica, Gerarda Altera, Anna Maria, Cristofanelli, Flavia, DʼAbramo, Alessandra, Bevilacqua, Nazario, Corpolongo, Angela, Puro, Vincenzo, Vaia, Francesco, Capobianchi, Maria Rosaria, Ippolito, Giuseppe, Nicastri, Emanuele, and Goletti, Delia

Published
2021
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19. Expansion of myeloid-derived suppressor cells in patients with severe coronavirus disease (COVID-19)

Author

Agrati, Chiara, Sacchi, Alessandra, Bordoni, Veronica, Cimini, Eleonora, Notari, Stefania, Grassi, Germana, Casetti, Rita, Tartaglia, Eleonora, Lalle, Eleonora, D’Abramo, Alessandra, Castilletti, Concetta, Marchioni, Luisa, Shi, Yufang, Mariano, Andrea, Song, Jin-Wen, Zhang, Ji-Yuan, Wang, Fu-Sheng, Zhang, Chao, Fimia, Gian Maria, Capobianchi, Maria R., Piacentini, Mauro, Antinori, Andrea, Nicastri, Emanuele, Maeurer, Markus, Zumla, Alimuddin, and Ippolito, Giuseppe

Published
2020
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20. Eye movement desensitization and reprocessing for depressed individuals with multiple sclerosis: A pilot study.

Author

Rovaris, Marco, Toselli, Elena, Mendozzi, Laura, Di Tella, Sonia, Pirastru, Alice, Blasi, Valeria, Baglio, Francesca, Ostacoli, Luca, D'Abramo, Alessandra, Incerti, Alessia, Fernandez, Isabel, Pagnini, Francesco, and Cavalera, Cesare

Subjects
EMDR (Eye-movement desensitization & reprocessing), MULTIPLE sclerosis, MENTAL health, MENTAL depression, PILOT projects
Abstract

Background: Multiple studies have highlighted elevated rates of depression among individuals with Multiple Sclerosis (MS), with its associated symptoms posing a significant threat to overall well-being. Moreover, existing literature suggests a potential interconnection between depressive manifestations and the decline of physical functionalities in the context of MS. Objective: to examine the viability of the Eye Movement Desensitization Reprocessing (EMDR) therapy protocol for the treatment of depressive disorders (DeprEND) for alleviating depression in individuals with MS. Methods: We conducted a process–outcome study to examine the feasibilty and effectiveness DeprEND enrolling 13 individuals with MS and depressive symtpoms. Psychological and physical assessment pre-, post-intervention and 3-month follow-up were included. Pre- and post-magnetic resonance imaging (MRI) scans were conducted to analyze potential alterations in brain function. Results: The EMDR DeprEND treatment showed a high level of adherence and feasibility. Significant reductions in depressive symptoms were found at post-intervention and at 3 months follow-up. No significant differences were observed in terms of physical symptoms. A significant modulation observed in parietal and premotor areas when examining negative valence stimuli post-treatment was found. Conclusion: for The EMDR DeprEND protocol may represent a feasible and cost-effective treatment for reducing depressive symptoms in MS patients and improving their mental well-being. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Dual combined antiviral treatment with remdesivir and nirmatrelvir/ritonavir in patients with impaired humoral immunity and persistent SARS‐CoV‐2 infection

Author

Pasquini, Zeno, primary, Toschi, Alice, additional, Casadei, Beatrice, additional, Pellegrini, Cinzia, additional, D’Abramo, Alessandra, additional, Vita, Serena, additional, Beccacece, Alessia, additional, Bussini, Linda, additional, Chionsini, Maria Clara, additional, Dentale, Nicola, additional, Cantiani, Alessia, additional, Lazzarotto, Tiziana, additional, Bartoletti, Michele, additional, Nicastri, Emanuele, additional, Zinzani, Pierluigi, additional, Giannella, Maddalena, additional, and Viale, Pierluigi, additional

Published
2023
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24. A machine learning approach for early identification of patients with severe imported malaria.

Author

D'Abramo, Alessandra, Rinaldi, Francesco, Vita, Serena, Mazzieri, Riccardo, Corpolongo, Angela, Palazzolo, Claudia, Ascoli Bartoli, Tommaso, Faraglia, Francesca, Giancola, Maria Letizia, Girardi, Enrico, and Nicastri, Emanuele

Abstract

Background: The aim of this study is to design ad hoc malaria learning (ML) approaches to predict clinical outcome in all patients with imported malaria and, therefore, to identify the best clinical setting. Methods: This is a single-centre cross-sectional study, patients with confirmed malaria, consecutively hospitalized to the Lazzaro Spallanzani National Institute for Infectious Diseases, Rome, Italy from January 2007 to December 2020, were recruited. Different ML approaches were used to perform the analysis of this dataset: support vector machines, random forests, feature selection approaches and clustering analysis. Results: A total of 259 patients with malaria were enrolled, 89.5% patients were male with a median age of 39 y/o. In 78.3% cases, Plasmodium falciparum was found. The patients were classified as severe malaria in 111 cases. From ML analyses, four parameters, AST, platelet count, total bilirubin and parasitaemia, are associated to a negative outcome. Interestingly, two of them, aminotransferase and platelet are not included in the current list of World Health Organization (WHO) criteria for defining severe malaria. Conclusion: In conclusion, the application of ML algorithms as a decision support tool could enable the clinicians to predict the clinical outcome of patients with malaria and consequently to optimize and personalize clinical allocation and treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Pharyngo-tonsillar involvement of Mpox in a cohort of men who have sex with men (MSM): A serious risk of missing diagnosis.

Author

Pinnetti, Carmela, Mondi, Annalisa, Mazzotta, Valentina, Vita, Serena, Carletti, Fabrizio, Aguglia, Camilla, Beccacece, Alessia, Vergori, Alessandra, Gagliardini, Roberta, Specchiarello, Eliana, Ascoli Bartoli, Tommaso, Baldini, Francesco, Giancola, Maria Letizia, Valli, Maria Beatrice, D'Abramo, Alessandra, Gebremeskel Teklè, Saba, Fontana, Carla, Garbuglia, Anna Rosa, Girardi, Enrico, and Maggi, Fabrizio

Abstract

During the 2022-outbreak, peculiar clinical presentations of Mpox have been described, some of which can make the diagnosis of the disease extremely challenging. Here we report a case series of fourteen patients with Mpox pharynogotonsillar involvement (PTI) seen at National Institute for Infectious Diseases, " Lazzaro Spallanzani ", in Rome, Italy from May to September 2022. All included patients were men who have sex with men (median age 38 years) reporting unprotected sex within three weeks from symptoms onset. Seven out of fourteen patients needed hospitalization due to uncontrolled pain, reduced airspace and difficulty swallowing, of whom five were effectively treated with tecovirimat or cidofovir. The remaining two patients were treated with symptomatic drugs. The typical Mpox muco-cutaneous manifestations were not observed simultaneously with PTI in three patients, two of whom developed the lesions after several days, while one never manifested them. Polymerase Chain Reaction (PCR) for Mpox virus was positive in oropharyngeal swab, saliva and serum. Although PTI occurs in only a small percentage of Mpox cases, its diagnosis is of utmost importance. In fact, this localization, if not identified, could lead to serious complications in the absence of early antiviral treatment and to missed diagnosis with an increased risk of disease transmission. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Immunological signature in human cases of monkeypox infection in 2022 outbreak: an observational study

Author

Agrati, Chiara, primary, Cossarizza, Andrea, additional, Mazzotta, Valentina, additional, Grassi, Germana, additional, Casetti, Rita, additional, De Biasi, Sara, additional, Pinnetti, Carmela, additional, Gili, Simona, additional, Mondi, Annalisa, additional, Cristofanelli, Flavia, additional, Lo Tartaro, Domenico, additional, Notari, Stefania, additional, Maffongelli, Gaetano, additional, Gagliardini, Roberta, additional, Gibellini, Lara, additional, Aguglia, Camilla, additional, Lanini, Simone, additional, D'Abramo, Alessandra, additional, Matusali, Giulia, additional, Fontana, Carla, additional, Nicastri, Emanuele, additional, Maggi, Fabrizio, additional, Girardi, Enrico, additional, Vaia, Francesco, additional, and Antinori, Andrea, additional

Published
2022
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27. The first case of meningitis associated with SARS-CoV-2 BA.2 variant infection with persistent viremia

Author

D'Abramo, Alessandra, primary, Vita, Serena, additional, Colavita, Francesca, additional, Cimini, Eleonora, additional, Haggiag, Shalom, additional, Maffongelli, Gaetano, additional, Valli, Maria Beatrice, additional, Bevilacqua, Nazario, additional, Corpolongo, Angela, additional, Giancola, Maria Letizia, additional, Maggi, Fabrizio, additional, Agrati, Chiara, additional, and Nicastri, Emanuele, additional

Published
2022
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30. Timing and outcomes of noninvasive ventilation in 307 ARDS COVID-19 patients: an observational study in an Italian third level COVID-19 hospital

Author

Tetaj, Nardi, primary, Piselli, Pierluca, additional, Zito, Sara, additional, De Angelis, Giada, additional, Marini, Maria Cristina, additional, Rubino, Dorotea, additional, Onnis, Ilaria, additional, Gaviano, Ilaria, additional, Antonica, Maria Vittoria, additional, Agostini, Elisabetta, additional, Porcelli, Candido, additional, Stazi, Giulia Valeria, additional, Garotto, Gabriele, additional, Busso, Donatella, additional, D’Aprano, Silvana Scarcia, additional, Navarra, Assunta, additional, Cimaglia, Claudia, additional, Topino, Simone, additional, Iacomi, Fabio, additional, D’Abramo, Alessandra, additional, Pinnetti, Carmela, additional, Gualano, Gina, additional, Capone, Alessandro, additional, Villanacci, Alberta, additional, Antinori, Andrea, additional, Palmieri, Fabrizio, additional, D’Offizi, Gianpiero, additional, Ianniello, Stefania, additional, Taglietti, Fabrizio, additional, Campioni, Paolo, additional, Vaia, Francesco, additional, Nicastri, Emanuele, additional, Girardi, Enrico, additional, and Marchioni, Luisa, additional

Published
2022
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31. Immunological Signature in Human Cases of Monkeypox Infection in 2022 Outbreak

Author

Agrati, Chiara, primary, Cossarizza, Andrea, additional, Mazzotta, Valentina, additional, Grassi, Germana, additional, Casetti, Rita, additional, De Biasi, Sara, additional, Pinnetti, Carmela, additional, Gili, Simona, additional, Mondi, Annalisa, additional, Cristofanelli, Flavia, additional, Lo Tartaro, Domenico, additional, Notari, Stefania, additional, Maffongelli, Gaetano, additional, Gagliardini, Roberta, additional, Gibellini, Lara, additional, Aguglia, Camilla, additional, Lanini, Simone, additional, D’Abramo, Alessandra, additional, Matusali, Giulia, additional, Fontana, Carla, additional, Nicastri, Emanuele, additional, Maggi, Fabrizio, additional, Girardi, Enrico, additional, Vaia, Francesco, additional, and Antinori, Andrea, additional

Published
2022
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33. Management of Spontaneous Bleeding in COVID-19 Inpatients: Is Embolization Always Needed?

Author

Riu, Pascale, primary, Albarello, Fabrizio, additional, Di Stefano, Federica, additional, Vergori, Alessandra, additional, D’Abramo, Alessandra, additional, Cerini, Carlo, additional, Nocioni, Martina, additional, Morucci, Maurizio, additional, Tetaj, Nardi, additional, Cristofaro, Massimo, additional, Schininà, Vincenzo, additional, Campioni, Paolo, additional, Petrone, Ada, additional, Fusco, Nicoletta, additional, Marchioni, Luisa, additional, Antinori, Andrea, additional, Nicastri, Emanuele, additional, Cianni, Roberto, additional, and Ianniello, Stefania, additional

Published
2021
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36. Additional file 2 of Systematic analysis of direct antiglobulin test results in post-artesunate delayed haemolysis

Author

Bartoli, Tommaso Ascoli, Lepore, Luciana, D’Abramo, Alessandra, Adamo, Giovanna, Corpolongo, Angela, Scorzolini, Laura, Giancola, Maria Letizia, Bevilacqua, Nazario, Palazzolo, Claudia, Mariano, Andrea, Ippolito, Giuseppe, Buffet, Pierre, and Nicastri, Emanuele

Abstract

Additional file 2. Epidemiological, clinical, and therapeutic characteristics of patients with PADH with an available DAT result reported as aggregate case series and stratified according to the administration of systemic steroids.

Published
2021
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38. Timing and Outcomes of Noninvasive Ventilation in 307 ARDS COVID-19 Patients: An Observational Study in an Italian Third Level COVID-19 Hospital.

Author

Tetaj, Nardi, Piselli, Pierluca, Zito, Sara, De Angelis, Giada, Marini, Maria Cristina, Rubino, Dorotea, Gaviano, Ilaria, Antonica, Maria Vittoria, Agostini, Elisabetta, Porcelli, Candido, Stazi, Giulia Valeria, Garotto, Gabriele, Busso, Donatella, Scarcia, Silvana, Navarra, Assunta, Cimaglia, Claudia, Topino, Simone, Iacomi, Fabio, D'Abramo, Alessandra, and Pinnetti, Carmela

Subjects
COVID-19, NONINVASIVE ventilation, CORONAVIRUS diseases, ADULT respiratory distress syndrome, LOGISTIC regression analysis, INTENSIVE care units
Abstract

Background and Objectives: Background: Coronavirus disease 2019 (COVID-19) is a novel cause of Acute Respiratory Distress Syndrome (ARDS). Noninvasive ventilation (NIV) is widely used in patients with ARDS across several etiologies. Indeed, with the increase of ARDS cases due to the COVID-19 pandemic, its use has grown significantly in hospital wards. However, there is a lack of evidence to support the efficacy of NIV in patients with COVID-19 ARDS. Materials and Methods: We conducted an observational cohort study including adult ARDS COVID-19 patients admitted in a third level COVID-center in Rome, Italy. The study analyzed the rate of NIV failure defined by the occurrence of orotracheal intubation and/or death within 28 days from starting NIV, its effectiveness, and the associated relative risk of death. The factors associated with the outcomes were identified through logistic regression analysis. Results: During the study period, a total of 942 COVID-19 patients were admitted to our hospital, of which 307 (32.5%) presented with ARDS at hospitalization. During hospitalization 224 (23.8%) were treated with NIV. NIV failure occurred in 84 (37.5%) patients. At 28 days from starting NIV, moderate and severe ARDS had five-fold and twenty-fold independent increased risk of NIV failure (adjusted odds ratio, aOR = 5.01, 95% CI 2.08–12.09, and 19.95, 95% CI 5.31–74.94), respectively, compared to patients with mild ARDS. A total of 128 patients (13.5%) were admitted to the Intensive Care Unit (ICU). At 28-day from ICU admission, intubated COVID-19 patients treated with early NIV had 40% lower mortality (aOR 0.60, 95% CI 0.25–1.46, p = 0.010) compared with patients that underwent orotracheal intubation without prior NIV. Conclusions: These findings show that NIV failure was independently correlated with the severity category of COVID-19 ARDS. The start of NIV in COVID-19 patients with mild ARDS (P/F > 200 mmHg) appears to increase NIV effectiveness and reduce the risk of orotracheal intubation and/or death. Moreover, early NIV (P/F > 200 mmHg) treatment seems to reduce the risk of ICU mortality at 28 days from ICU admission. [ABSTRACT FROM AUTHOR]

Published
2022
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39. Epidemiological, clinical and virological characteristics of four cases of monkeypox support transmission through sexual contact, Italy, May 2022.

Author

Antinori, Andrea, Mazzotta, Valentina, Vita, Serena, Carletti, Fabrizio, Tacconi, Danilo, Lapini, Laura Emma, D'Abramo, Alessandra, Cicalini, Stefania, Lapa, Daniele, Pittalis, Silvia, Puro, Vincenzo, Rivano Capparuccia, Marco, Giombini, Emanuela, Maria Gruber, Cesare Ernesto, Garbuglia, Anna Rosa, Marani, Alessandra, Vairo, Francesco, Girardi, Enrico, Vaia, Francesco, and Nicastri, Emanuele

Published
2022
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40. Risk and predictive factors of prolonged viral RNA shedding in upper respiratory specimens in a large cohort of COVID-19 patients admitted to an Italian reference hospital

Author

Mondi, Annalisa, primary, Lorenzini, Patrizia, additional, Castilletti, Concetta, additional, Gagliardini, Roberta, additional, Lalle, Eleonora, additional, Corpolongo, Angela, additional, Valli, Maria Beatrice, additional, Taglietti, Fabrizio, additional, Cicalini, Stefania, additional, Loiacono, Laura, additional, Di Gennaro, Francesco, additional, D’Offizi, Gianpiero, additional, Palmieri, Fabrizio, additional, Nicastri, Emanuele, additional, Agrati, Chiara, additional, Petrosillo, Nicola, additional, Ippolito, Giuseppe, additional, Vaia, Francesco, additional, Girardi, Enrico, additional, Capobianchi, Maria Rosaria, additional, Antinori, Andrea, additional, Zito, Sara, additional, Abbonizio, Maria Alessandra, additional, Abdeddaim, Amina, additional, Agostini, Elisabetta, additional, Albarello, Fabrizio, additional, Amadei, Gioia, additional, Amendola, Alessandra, additional, Antonica, Maria Assunta, additional, Antonini, Mario, additional, Bartoli, Tommaso Ascoli, additional, Baldini, Francesco, additional, Barbaro, Raffaella, additional, Bartolini, Barbara, additional, Bellagamba, Rita, additional, Benigni, Martina, additional, Bevilacqua, Nazario, additional, Biava, Gianluigi, additional, Bibas, Michele, additional, Bordi, Licia, additional, Bordoni, Veronica, additional, Boumis, Evangelo, additional, Branca, Marta, additional, Buonomo, Rosanna, additional, Busso, Donatella, additional, Camici, Marta, additional, Campioni, Paolo, additional, Canichella, Flaminia, additional, Capone, Alessandro, additional, Caporale, Cinzia, additional, Caraffa, Emanuela, additional, Caravella, Ilaria, additional, Carletti, Fabrizio, additional, Cataldo, Adriana, additional, Cerilli, Stefano, additional, Cerva, Carlotta, additional, Chiappini, Roberta, additional, Chinello, Pierangelo, additional, Cianfarani, Maria Assunta, additional, Ciaralli, Carmine, additional, Cimaglia, Claudia, additional, Cinicola, Nicola, additional, Ciotti, Veronica, additional, Colavita, Francesca, additional, Cristofaro, Massimo, additional, Curiale, Salvatore, additional, D’Abramo, Alessandra, additional, Dantimi, Cristina, additional, De Angelis, Alessia, additional, De Angelis, Giada, additional, De Palo, Maria Grazia, additional, De Zottis, Federico, additional, Di Bari, Virginia, additional, Di Lorenzo, Rachele, additional, Di Stefano, Federica, additional, Donno, Davide, additional, Evangelista, Francesca, additional, Faraglia, Francesca, additional, Farina, Anna, additional, Ferraro, Federica, additional, Fiorentini, Lorena, additional, Frustaci, Andrea, additional, Fusetti, Matteo, additional, Galati, Vincenzo, additional, Gallì, Paola, additional, Garotto, Gabriele, additional, Gaviano, Ilaria, additional, Tekle, Saba Gebremeskel, additional, Giancola, Maria Letizia, additional, Giansante, Filippo, additional, Giombini, Emanuela, additional, Granata, Guido, additional, Greci, Maria Cristina, additional, Grilli, Elisabetta, additional, Grisetti, Susanna, additional, Gualano, Gina, additional, Iacomi, Fabio, additional, Iaconi, Marta, additional, Iannicelli, Giuseppina, additional, Inversi, Carlo, additional, Lamanna, Maria Elena, additional, Lanini, Simone, additional, Lapa, Daniele, additional, Lepore, Luciana, additional, Libertone, Raffaella, additional, Lionetti, Raffaella, additional, Liuzzi, Giuseppina, additional, Lucia, Andrea, additional, Lufrani, Franco, additional, Macchione, Manuela, additional, Maffongelli, Gaetano, additional, Marani, Alessandra, additional, Marchioni, Luisa, additional, Mariano, Andrea, additional, Marini, Maria Cristina, additional, Maritti, Micaela, additional, Mastrobattista, Annelisa, additional, Mastrorosa, Ilaria, additional, Matusali, Giulia, additional, Mazzotta, Valentina, additional, Mencarini, Paola, additional, Meschi, Silvia, additional, Messina, Francesco, additional, Micarelli, Sibiana, additional, Mogavero, Giulia, additional, Mondi, Annalisa, additional, Montalbano, Marzia, additional, Montaldo, Chiara, additional, Mosti, Silvia, additional, Murachelli, Silvia, additional, Musso, Maria, additional, Nardi, Michela, additional, Navarra, Assunta, additional, Nocioni, Martina, additional, Noto, Pasquale, additional, Noto, Roberto, additional, Oliva, Alessandra, additional, Onnis, Ilaria, additional, Ottou, Sandrine, additional, Palazzolo, Claudia, additional, Pallini, Emanuele, additional, Palombi, Giulio, additional, Pareo, Carlo, additional, Passeri, Virgilio, additional, Pelliccioni, Federico, additional, Penna, Giovanna, additional, Petrecchia, Antonella, additional, Petrone, Ada, additional, Pianura, Elisa, additional, Pinnetti, Carmela, additional, Pisciotta, Maria, additional, Piselli, Pierluca, additional, Pittalis, Silvia, additional, Pontarelli, Agostina, additional, Proietti, Costanza, additional, Puro, Vincenzo, additional, Ramazzini, Paolo Migliorisi, additional, Rianda, Alessia, additional, Rinonapoli, Gabriele, additional, Rosati, Silvia, additional, Rubino, Dorotea, additional, Rueca, Martina, additional, Ruggeri, Alberto, additional, Sacchi, Alessandra, additional, Sampaolesi, Alessandro, additional, Sanasi, Francesco, additional, Santagata, Carmen, additional, Scarabello, Alessandra, additional, Scarcia, Silvana, additional, Schininà, Vincenzo, additional, Scognamiglio, Paola, additional, Scorzolini, Laura, additional, Stazi, Giulia, additional, Strano, Giacomo, additional, Taibi, Chiara, additional, Taloni, Giorgia, additional, Nardi, Tetaj, additional, Tonnarini, Roberto, additional, Topino, Simone, additional, Tozzi, Martina, additional, Vairo, Francesco, additional, Vergori, Alessandra, additional, Vincenzi, Laura, additional, Visco-Comandini, Ubaldo, additional, Vita, Serena, additional, Vittozzi, Pietro, additional, Zaccarelli, Mauro, additional, and Zanetti, Antonella, additional

Published
2021
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41. Pharmacokinetics of remdesivir and GS-441524 in two critically ill patients who recovered from COVID-19

Author

Tempestilli, Massimo, Caputi, Priscilla, Avataneo, Valeria, Notari, Stefania, Forini, Olindo, Scorzolini, Laura, Marchioni, Luisa, Ascoli Bartoli, Tommaso, Castilletti, Concetta, Lalle, Eleonora, Capobianchi, Maria R, Nicastri, Emanuele, D’Avolio, Antonio, Ippolito, Giuseppe, Agrati, Chiara, Abbonizio, Maria Alessandra, Albarello, Fabrizio, Amadei, Gioia, Amendola, Alessandra, Antinori, Andrea, Antonini, Mario, Barbaro, Raffaella, Bartolini, Barbara, Benigni, Martina, Bevilacqua, Nazario, Bordi, Licia, Bordoni, Veronica, Branca, Marta, Campioni, Paolo, Capobianchi, Maria Rosaria, Caporale, Cinzia, Caravella, Ilaria, Carletti, Fabrizio, Casetti, Rita, Chiappini, Roberta, Ciaralli, Carmine, Cimini, Eleonora, Colavita, Francesca, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, De Angelis, Alessia, De Angelis, Giada, Di Lorenzo, Rachele, Di Stefano, Federica, D’Offizi, Gianpiero, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Gallì, Paola, Garotto, Gabriele, Giancola, Maria Letizia, Giansante, Filippo, Giombini, Emanuela, Grassi, Germana, Greci, Maria Cristina, Lanini, Simone, Lapa, Daniele, Lepore, Luciana, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Marani, Alessandra, Mariano, Andrea, Marini, Maria Cristina, Maritti, Micaela, Matusali, Giulia, Meschi, Silvia, Messina, Francesco, Montaldo, Chiara, Murachelli, Silvia, Noto, Roberto, Palazzolo, Claudia, Pallini, Emanuele, Palmieri, Fabrizio, Passeri, Virgilio, Pelliccioni, Federico, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pisciotta, Maria, Pittalis, Silvia, Proietti, Costanza, Puro, Vincenzo, Rinonapoli, Gabriele, Rueca, Martina, Sacchi, Alessandra, Sanasi, Francesco, Santagata, Carmen, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Stazi, Giulia, Vaia, Francesco, Vairo, Francesco, and Valli, Maria Beatrice

Subjects
0301 basic medicine, Drug, Male, Microbiology (medical), medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), COVID19, media_common.quotation_subject, Critical Illness, 030106 microbiology, Pneumonia, Viral, remdesivir, Loading dose, Gastroenterology, Antiviral Agents, NO, 03 medical and health sciences, Betacoronavirus, Adenosine Triphosphate, Pharmacokinetics, Internal medicine, medicine, Humans, Pharmacology (medical), Pandemics, media_common, EC50, Original Research, Aged, Pharmacology, Lung, Alanine, Nucleoside analogue, business.industry, SARS-CoV-2, COVID-19, Recovery of Function, Prodrug, Adenosine Monophosphate, 030104 developmental biology, medicine.anatomical_structure, Infectious Diseases, Pharmacokinetics, COVID19, remdesivir, Female, business, Coronavirus Infections, medicine.drug
Abstract

Background Remdesivir is a prodrug of the nucleoside analogue GS-441524 and is under evaluation for treatment of SARS-CoV-2-infected patients. Objectives To evaluate the pharmacokinetics of remdesivir and GS-441524 in plasma, bronchoalveolar aspirate (BAS) and CSF in two critically ill COVID-19 patients. Methods Remdesivir was administered at 200 mg loading dose on the first day followed by 12 days of 100 mg in two critically ill patients. Blood samples were collected immediately after (C0) and at 1 (C1) and 24 h (C24) after intravenous administration on day 3 until day 9. BAS samples were collected on Days 4, 7 and 9 from both patients while one CSF on Day 7 was obtained in one patient. Remdesivir and GS-441524 concentrations were measured in these samples using a validated UHPLC-MS/MS method. Results We observed higher concentrations of remdesivir at C0 (6- to 7-fold higher than EC50 from in vitro studies) and a notable decay at C1. GS-441524 plasma concentrations reached a peak at C1 and persisted until the next administration. Higher concentrations of GS-441524 were observed in the patient with mild renal dysfunction. Mean BAS/plasma concentration ratios of GS-441524 were 2.3% and 6.4% in Patient 1 and Patient 2, respectively. The CSF concentration found in Patient 2 was 25.7% with respect to plasma. GS-441524 levels in lung and CNS suggest compartmental differences in drug exposure. Conclusions We report the first pharmacokinetic evaluation of remdesivir and GS-441524 in recovered COVID-19 patients. Further study of the pharmacokinetic profile of remdesivir, GS-441524 and the intracellular triphosphate form are required.

Published
2020
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42. Development of a clinical decision support system for severity risk prediction and triage of COVID-19 patients at hospital admission: an international multicentre study

Author

Wu, Guangyao, Wu, Guangyao, Yang, Pei, Xie, Yuanliang, Woodruff, Henry C., Rao, Xiangang, Guiot, Julien, Frix, Anne-Noelle, Louis, Renaud, Moutschen, Michel, Li, Jiawei, Li, Jing, Yan, Chenggong, Du, Dan, Zhao, Shengchao, Ding, Yi, Liu, Bin, Sun, Wenwu, Albarello, Fabrizio, D'Abramo, Alessandra, Schinina, Vincenzo, Nicastri, Emanuele, Occhipinti, Mariaelena, Barisione, Giovanni, Barisione, Emanuela, Halilaj, Iva, Lovinfosse, Pierre, Wang, Xiang, Wu, Jianlin, Lambin, Philippe, Wu, Guangyao, Wu, Guangyao, Yang, Pei, Xie, Yuanliang, Woodruff, Henry C., Rao, Xiangang, Guiot, Julien, Frix, Anne-Noelle, Louis, Renaud, Moutschen, Michel, Li, Jiawei, Li, Jing, Yan, Chenggong, Du, Dan, Zhao, Shengchao, Ding, Yi, Liu, Bin, Sun, Wenwu, Albarello, Fabrizio, D'Abramo, Alessandra, Schinina, Vincenzo, Nicastri, Emanuele, Occhipinti, Mariaelena, Barisione, Giovanni, Barisione, Emanuela, Halilaj, Iva, Lovinfosse, Pierre, Wang, Xiang, Wu, Jianlin, and Lambin, Philippe

Abstract

Background: The outbreak of coronavirus disease 2019 (COVID-19) has globally strained medical resources and caused significant mortality.Objective To develop and validate a machine-learning model based on clinical features for severity risk assessment and triage for COVID-19 patients at hospital admission.Method: 725 patients were used to train and validate the model. This included a retrospective cohort from Wuhan, China of 299 hospitalised COVID-19 patients from 23 December 2019 to 13 February 2020, and five cohorts with 426 patients from eight centres in China, Italy and Belgium from 20 February 2020 to 21 March 2020. The main outcome was the onset of severe or critical illness during hospitalisation. Model performances were quantified using the area under the receiver operating characteristic curve (AUC) and metrics derived from the confusion matrix.Results: In the retrospective cohort, the median age was 50 years and 137 (45.8%) were male. In the five test cohorts, the median age was 62 years and 236 (55.4%) were male. The model was prospectively validated on five cohorts yielding AUCs ranging from 0.84 to 0.93, with accuracies ranging from 74.4% to 87.5%, sensitivities ranging from 75.0% to 96.9%, and specificities ranging from 55.0% to 88.0%, most of which performed better than the pneumonia severity index. The cut-off values of the low-, medium- and high-risk probabilities were 0.21 and 0.80. The online calculators can be found at www.covid19risk.ai.Conclusion: The machine-learning model, nomogram and online calculator might be useful to access the onset of severe and critical illness among COVID-19 patients and triage at hospital admission.

Published
2020

43. Artemisinin resistance surveillance in African Plasmodium falciparum isolates from imported malaria cases to Italy

Author

L'Episcopia, Mariangela, primary, Bartoli, Tommaso Ascoli, additional, Corpolongo, Angela, additional, Mariano, Andrea, additional, D’Abramo, Alessandra, additional, Vulcano, Antonella, additional, Paglia, Maria G, additional, Perrotti, Edvige, additional, Menegon, Michela, additional, Nicastri, Emanuele, additional, and Severini, Carlo, additional

Published
2020
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44. Clinical Management of Patients With B-Cell Depletion Agents to Treat or Prevent Prolonged and Severe SARS-COV-2 Infection: Defining a Treatment Pathway.

Author

D’Abramo, Alessandra, Vita, Serena, Maffongelli, Gaetano, Beccacece, Alessia, Agrati, Chiara, Cimini, Eleonora, Colavita, Francesca, Giancola, Maria Letizia, Cavasio, Alessandro, and Nicastri, Emanuele

Abstract

Introduction: Immunocompromised patients with B-cell depletion agents are at risk for persistence and/or severe SARS-COV-2 infection. We describe a case series of 21 COVID-19 patients under B cell depletion therapy, mostly treated with a combined therapy based on intravenous remdesevir (RDV) and steroid associated with SARS-CoV-2 monoclonal antibodies against Spike glycoprotein and/or hyper-immune convalescent plasma. Methods: This is a single-center longitudinal study. We retrospectively enrolled a total number of 21 B-cell depleted consecutive hospitalized patients with COVID-19 at the Lazzaro Spallanzani National Institute for Infectious Diseases, Rome, Italy, from November 2020 to December 2021. Demographic characteristics, medical history, clinical presentation, treatment, adverse drug reactions, and clinical and virological outcome were collected for all patients. In a subgroup, we explore immune T cells activation, T cells specific anti-SARS-COV-2 response, and neutralizing antibodies. Results: Twenty-one inpatients with B-cell depletion and SARS-COV-2 infection were enrolled. A median of 1 B cells/mm3 was detected. Eighteen patients presented hypogammaglobulinemia. All patients presented interstitial pneumonia treated with intravenous RDV and steroids. Sixteen patients were treated with monoclonal antibodies against SARS-CoV-2 Spike protein, four patients were treated with SARS-CoV-2 hyper-immune convalescent plasma infusion, and three patients received both treatments. A variable kinetic of T cell activation returning to normal levels at Day 30 after immunotherapy infusion was observed. All treated patients recovered. Conclusion: In COVID-19 immunosuppressed subjects, it is mandatory to establish a prompt, effective, and combined multi-target therapy including oxygen, antiviral, steroid, and antibody-based therapeutics, tailored to the patient’s clinical needs. [ABSTRACT FROM AUTHOR]

Published
2022
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45. Systematic Analysis of Direct Antiglobulin Test Results in Post-artesunate Delayed Hemolysis

Author

Bartoli, Tommaso Ascoli, primary, Lepore, Luciana, additional, D'Abramo, Alessandra, additional, Adamo, Giovanna, additional, Corpolongo, Angela, additional, Scorzolini, Laura, additional, Giancola, Maria Letizia, additional, Bevilacqua, Nazario, additional, Palazzolo, Claudia, additional, Mariano, Andrea, additional, Ippolito, Giuseppe, additional, Buffet, Pierre, additional, and Nicastri, Emanuele, additional

Published
2020
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46. Authors’ response: importance of a careful investigation to avoid attributing Legionnaires’ disease cases to an incorrect source of infection

Author

Palazzolo, Claudia, primary, Maffongelli, Gaetano, additional, D’Abramo, Alessandra, additional, Lepore, Luciana, additional, Mariano, Andrea, additional, Vulcano, Antonella, additional, Bartoli, Tommaso Ascoli, additional, Bevilacqua, Nazario, additional, Giancola, Maria Letizia, additional, Di Rosa, Enrico, additional, and Nicastri, Emanuele, additional

Published
2020
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48. Legionella pneumonia: increased risk after COVID-19 lockdown? Italy, May to June 2020

Author

Palazzolo, Claudia, primary, Maffongelli, Gaetano, additional, D’Abramo, Alessandra, additional, Lepore, Luciana, additional, Mariano, Andrea, additional, Vulcano, Antonella, additional, Bartoli, Tommaso Ascoli, additional, Bevilacqua, Nazario, additional, Giancola, Maria Letizia, additional, Di Rosa, Enrico, additional, and Nicastri, Emanuele, additional

Published
2020
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49. Development of a Clinical Decision Support System for Severity Risk Prediction and Triage of COVID-19 Patients at Hospital Admission: an International Multicenter Study

Author

Wu, Guangyao, primary, Yang, Pei, additional, Xie, Yuanliang, additional, Woodruff, Henry C., additional, Rao, Xiangang, additional, Guiot, Julien, additional, Frix, Anne-Noelle, additional, Louis, Renaud, additional, Moutschen, Michel, additional, Li, Jiawei, additional, Li, Jing, additional, Yan, Chenggong, additional, Du, Dan, additional, Zhao, Shengchao, additional, Ding, Yi, additional, Liu, Bin, additional, Sun, Wenwu, additional, Albarello, Fabrizio, additional, D'Abramo, Alessandra, additional, Schininà, Vincenzo, additional, Nicastri, Emanuele, additional, Occhipinti, Mariaelena, additional, Barisione, Giovanni, additional, Barisione, Emanuela, additional, Halilaj, Iva, additional, Lovinfosse, Pierre, additional, Wang, Xiang, additional, Wu, Jianlin, additional, and Lambin, Philippe, additional

Published
2020
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50. 2019-novel Coronavirus severe adult respiratory distress syndrome in two cases in Italy: An uncommon radiological presentation

Author

Albarello, Fabrizio, primary, Pianura, Elisa, additional, Di Stefano, Federica, additional, Cristofaro, Massimo, additional, Petrone, Ada, additional, Marchioni, Luisa, additional, Palazzolo, Claudia, additional, Schininà, Vincenzo, additional, Nicastri, Emanuele, additional, Petrosillo, Nicola, additional, Campioni, Paolo, additional, Eskild, Petersen, additional, Zumla, Alimuddin, additional, Ippolito, Giuseppe, additional, Abbonizio, Maria Alessandra, additional, Agrati, Chiara, additional, Albarello, Fabrizio, additional, Amadei, Gioia, additional, Amendola, Alessandra, additional, Antonini, Mario, additional, Barbaro, Raffaella, additional, Bartolini, Barbara, additional, Benigni, Martina, additional, Bevilacqua, Nazario, additional, Bordi, Licia, additional, Bordoni, Veronica, additional, Branca, Marta, additional, Capobianchi, Maria Rosaria, additional, Caporale, Cinzia, additional, Caravella, Ilaria, additional, Carletti, Fabrizio, additional, Castilletti, Concetta, additional, Chiappini, Roberta, additional, Ciaralli, Carmine, additional, Colavita, Francesca, additional, Corpolongo, Angela, additional, Curiale, Salvatore, additional, D’Abramo, Alessandra, additional, Dantimi, Cristina, additional, Angelis, Alessia De, additional, Angelis, Giada De, additional, Lorenzo, Rachele Di, additional, Stefano, Federica Di, additional, Ferraro, Federica, additional, Fiorentini, Lorena, additional, Frustaci, Andrea, additional, Gallì, Paola, additional, Garotto, Gabriele, additional, Giancola, Maria Letizia, additional, Giansante, Filippo, additional, Giombini, Emanuela, additional, Greci, Maria Cristina, additional, Lalle, Eleonora, additional, Lanini, Simone, additional, Lapa, Daniele, additional, Lepore, Luciana, additional, Lucia, Andrea, additional, Lufrani, Franco, additional, Macchione, Manuela, additional, Marani, Alessandra, additional, Mariano, Andrea, additional, Marini, Maria Cristina, additional, Maritti, Micaela, additional, Matusali, Giulia, additional, Meschi, Silvia, additional, Montaldo, Francesco Messina Chiara, additional, Murachelli, Silvia, additional, Noto, Roberto, additional, Pallini, Emanuele, additional, Passeri, Virgilio, additional, Pelliccioni, Federico, additional, Petrecchia, Antonella, additional, Pisciotta, Maria, additional, Pittalis, Silvia, additional, Proietti, Costanza, additional, Puro, Vincenzo, additional, Rinonapoli, Gabriele, additional, Rueca, Martina, additional, Sacchi, Alessandra, additional, Sanasi, Francesco, additional, Santagata, Carmen, additional, Scarcia, Silvana, additional, Scognamiglio, Paola, additional, Scorzolini, Laura, additional, Stazi, Giulia, additional, Vaia, Francesco, additional, Vairo, Francesco, additional, and Valli, Maria Beatrice, additional

Published
2020
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