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Your search keyword '"Czyzewski, Ann M."' showing total 16 results
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16 results on '"Czyzewski, Ann M."'

6. Effective in vivo treatment of acute lung injury with helical, amphipathic peptoid mimics of pulmonary surfactant proteins

Author

Czyzewski, Ann M., primary, McCaig, Lynda M., additional, Dohm, Michelle T., additional, Broering, Lauren A., additional, Yao, Li-Juan, additional, Brown, Nathan J., additional, Didwania, Maruti K., additional, Lin, Jennifer S., additional, Lewis, Jim F., additional, Veldhuizen, Ruud, additional, and Barron, Annelise E., additional

Published
2018
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7. Biophysical mimicry of lung surfactant protein B by random nylon-3 copolymers

Author

Dohm, Michelle T., Mowery, Brendan P., Czyzewski, Ann M., Stahl, Shannon S., Gellman, Samuel H., and Barron, Annelise E.

Subjects
Biomimetics -- Research, Lungs -- Physiological aspects, Nylon -- Structure, Nylon -- Chemical properties, Surface active agents -- Structure, Surface active agents -- Chemical properties, Genetic translation -- Analysis, Chemistry
Abstract

An alternative approach to imitation of lung surfactant proteins B and C (SP-B and SP-C), two helical and amphiphilic proteins that are critical for normal respiration, based on sequence-random copolymers containing cationic and lipophilic subunits is described. The study provides evidence for the sequence-random copolymers that could mimic the in vitro surface-active behavior of lung surfactant proteins in a mixed lipid film and their useful application for developing a lung surfactant replacement.

Published
2010

8. Pilot-Plant Preparation of an αvβ3 Integrin Antagonist. Part 3. Process Research and Development of a Diisopropylcarbodiimide and Catalytic 1-Hydroxybenzotriazole Peptide Coupling

Author

Ajit S. Shah, Thomas Rogers, James Murphy, Bruce E. Wise, D. Keith Anderson, Harish K. Santhanam, Mark A. Pietz, H. Peter Kleine, Derek B. Brown, V. H. Iskos, Jerry D. Clark, Melissa K. Lantz, Christine M. V. Moore, David V. Banaszak, Peter G. Ruminski, Czyzewski Ann M, Carlos A. Orihuela, Puneh S. Forouzi, Carl M. Knable, Gerald A. Weisenburger, Frank W. Muellner, Mark A. Lapack, Schilke Tobin C, Donald J. Gallagher, Albert D. Edeny, and Ahmad Y. Sheikh

Subjects
chemistry.chemical_classification, Hydroxybenzoic acid, Chemistry, Organic Chemistry, Hydroxybenzotriazole, Peptide, Coupling reaction, Catalysis, chemistry.chemical_compound, Zwitterion, Yield (chemistry), Organic chemistry, Physical and Theoretical Chemistry, Saponification
Abstract

Studies directed toward the process research, development, and scale-up preparation of the potential αvβ3 integrin antagonist 1 are described. A convergent approach is detailed wherein tetrahydropyrimidine hydroxybenzoic acid 2 is linked to the β-amino acid ester 3 via a diisoproylcarbodiimide, catalytic HOBt coupling reaction. Saponification of the resulting ethyl ester, isolation of the corresponding zwitterion, H3PO4 salt formation, crystallization, and acetonitrile-to-acetone exchange give rise to 1 as a crystalline monohydrate in 67% overall yield from 4.

Published
2009
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13. Pilot-Plant Preparation of an αvβ3 Integrin Antagonist. Part 3. Process Research and Development of a Diisopropylcarbodiimide and Catalytic 1-Hydroxybenzotriazole Peptide Coupling

Author

Clark, Jerry D., primary, Anderson, D. Keith, additional, Banaszak, David V., additional, Brown, Derek B., additional, Czyzewski, Ann M., additional, Edeny, Albert D., additional, Forouzi, Puneh S., additional, Gallagher, Donald J., additional, Iskos, V. H., additional, Kleine, H. Peter, additional, Knable, Carl M., additional, Lantz, Melissa K., additional, Lapack, Mark A., additional, Moore, Christine M. V., additional, Muellner, Frank W., additional, Murphy, James B., additional, Orihuela, Carlos A., additional, Pietz, Mark A., additional, Rogers, Thomas E., additional, Ruminski, Peter G., additional, Santhanam, Harish K., additional, Schilke, Tobin C., additional, Shah, Ajit S., additional, Sheikh, Ahmad Y., additional, Weisenburger, Gerald A., additional, and Wise, Bruce E., additional

Published
2009
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15. Pilot-Plant Preparation of an αvβ3Integrin Antagonist. Part 3. Process Research and Development of a Diisopropylcarbodiimide and Catalytic 1-Hydroxybenzotriazole Peptide Coupling†.

Author

Clark, Jerry D., Anderson, D. Keith, Banaszak, David V., Brown, Derek B., Czyzewski, Ann M., Edeny, Albert D., Forouzi, Puneh S., Gallagher, Donald J., Iskos, V. H., Kleine, H. Peter, Knable, Carl M., Lantz, Melissa K., Lapack, Mark A., Moore, Christine M. V., Muellner, Frank W., Murphy, James B., Orihuela, Carlos A., Pietz, Mark A., Rogers, Thomas E., and Ruminski, Peter G.

Published
2009
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16. Protein and Peptide Biomimicry: Gold-Mining Inspiration from Nature's Ingenuity.

Author

Czyzewski, Ann M. and Barron, Annelise E.

Subjects
MIMICRY (Biology), MOLECULES, PROTEINS, PROTEIN folding, BIOLOGICAL systems, SOLID-phase analysis
Abstract

This article presents research on the mimicry of natural molecules, particularly proteins. Biomimicry refers to a design principle that uses Nature as model, mentor and measure. Recapitulating protein function in simplified synthetic scaffolds or foldamers is an alternative approach to circumventing the protein folding problem. Foldamers have the ability to mimic a variety of simple secondary structures and are advantageous for mimicking biological systems. The use of synthetic methods for making foldamers have been adapted from solid-phase methods for conventional peptides.

Published
2008
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