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16 results on '"Czogala, Malgorzata"'

1. Hypodiploidy has unfavorable impact on survival in pediatric acute myeloid leukemia: an I-BFM Study Group collaboration

Author

Hammer, Anne Sofie Borg, Juul-Dam, Kristian Løvvik, Sandahl, Julie Damgaard, Abrahamsson, Jonas, Czogala, Malgorzata, Delabesse, Emmanuelle, Haltrich, Iren, Jahnukainen, Kirsi, Kolb, E. Anders, Kovács, Gábor, Leverger, Guy, Locatelli, Franco, Masetti, Riccardo, Noren-Nyström, Ulrika, Raimondi, Susana C., Rasche, Mareike, Reinhardt, Dirk, Taki, Tomohiko, Tomizawa, Daisuke, Zeller, Bernward, Hasle, Henrik, and Kjeldsen, Eigil

Published
2023
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2. Gemtuzumab ozogamicin for relapsed or primary refractory acute myeloid leukemia in children—the Polish Pediatric Leukemia and Lymphoma Study Group experience

Author

Pawinska-Wasikowska, Katarzyna, primary, Czogala, Malgorzata, additional, Skoczen, Szymon, additional, Surman, Marta, additional, Rygielska, Monika, additional, Ksiazek, Teofila, additional, Pac, Agnieszka, additional, Wieczorek, Aleksandra, additional, Skalska-Sadowska, Jolanta, additional, Samborska, Magdalena, additional, Wachowiak, Jacek, additional, Chaber, Radoslaw, additional, Tomaszewska, Renata, additional, Szczepanski, Tomasz, additional, Zielezinska, Karolina, additional, Urasinski, Tomasz, additional, Moj-Hackemer, Malgorzata, additional, Kalwak, Krzysztof, additional, Kozlowska, Marta, additional, Irga-Jaworska, Ninela, additional, Balwierz, Walentyna, additional, and Bukowska-Strakova, Karolina, additional

Published
2023
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3. Prognostic impact of t(16;21)(p11;q22) and t(16;21)(q24;q22) in pediatric AML: a retrospective study by the I-BFM Study Group

Author

Noort, Sanne, Zimmermann, Martin, Reinhardt, Dirk, Cuccuini, Wendy, Pigazzi, Martina, Smith, Jenny, Ries, Rhonda E., Alonzo, Todd A., Hirsch, Betsy, Tomizawa, Daisuke, Locatelli, Franco, Gruber, Tanja A., Raimondi, Susana, Sonneveld, Edwin, Cheuk, Daniel K., Dworzak, Michael, Stary, Jan, Abrahamsson, Jonas, Arad-Cohen, Nira, Czogala, Malgorzata, De Moerloose, Barbara, Hasle, Henrik, Meshinchi, Soheil, van den Heuvel-Eibrink, Marry, and Zwaan, C. Michel

Published
2018
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5. Hypodiploidy has unfavorable impact on survival in pediatric acute myeloid leukemia : An I-BFM Study Group collaboration

Author

Borg Hammer, Anne Sofie, Løvvik Juul-Dam, Kristian, Damgaard Sandahl, Julie, Abrahamsson, Jonas, Czogala, Malgorzata, Delabesse, Emmanuelle, Haltrich, Iren, Jahnukainen, Kirsi, Kolb, E. Anders, Kovács, Gábor, Leverger, Guy, Locatelli, Franco, Masetti, Riccardo, Norén-Nyström, Ulrika, Raimondi, Susana C., Rasche, Mareike, Reinhardt, Dirk, Taki, Tomohiko, Tomizawa, Daisuke, Zeller, Bernward, Hasle, Henrik, Kjeldsen, Eigil, Borg Hammer, Anne Sofie, Løvvik Juul-Dam, Kristian, Damgaard Sandahl, Julie, Abrahamsson, Jonas, Czogala, Malgorzata, Delabesse, Emmanuelle, Haltrich, Iren, Jahnukainen, Kirsi, Kolb, E. Anders, Kovács, Gábor, Leverger, Guy, Locatelli, Franco, Masetti, Riccardo, Norén-Nyström, Ulrika, Raimondi, Susana C., Rasche, Mareike, Reinhardt, Dirk, Taki, Tomohiko, Tomizawa, Daisuke, Zeller, Bernward, Hasle, Henrik, and Kjeldsen, Eigil

Abstract

Hypodiploidy, defined as modal numbers (MNs) 45 or lower, has not been independently investigated in pediatric acute myeloid leukemia (AML) but is a well-described high-risk factor in pediatric acute lymphoblastic leukemia. We aimed to characterize and study the prognostic impact of hypodiploidy in pediatric AML. In this retrospective cohort study, we included children below 18 years of age with de novo AML and a hypodiploid karyotype diagnosed from 2000 to 2015 in 14 childhood AML groups from the International Berlin-Frankfurt-Münster (I-BFM) framework. Exclusion criteria comprised constitutional hypodiploidy, monosomy 7, composite karyotype, and t(8;21) with concurring sex chromosome loss. Hypodiploidy occurred in 81 patients (1.3%) with MNs, 45 (n = 66); 44 (n = 10) and 43 (n = 5). The most frequently lost chromosomes were chromosome 9 and sex chromosomes. Five-year event-free survival (EFS) and overall survival (OS) were 34% and 52%, respectively, for the hypodiploid cohort. Children with MN≤44 (n = 15) had inferior EFS (21%) and OS (33%) compared with children with MN = 45 (n = 66; EFS, 37%; OS, 56%). Adjusted hazard ratios (HRs) were 4.9 (P = .001) and 6.1 (P = .003). Monosomal karyotype or monosomy 9 had particular poor OS (43% and 15%, respectively). Allogeneic stem cell transplantation (SCT) in first complete remission (CR1) (n = 18) did not mitigate the unfavorable outcome of hypodiploidy (adjusted HR for OS was 1.5; P = .42). We identified pediatric hypodiploid AML as a rare subgroup with an inferior prognosis even in the patients treated with SCT in CR1.

Published
2023
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6. Gemtuzumab ozogamicin for relapsed or primary refractory acute myeloid leukemia in children--the Polish Pediatric Leukemia and Lymphoma Study Group experience.

Author

Pawinska-Wasikowska, Katarzyna, Czogala, Malgorzata, Skoczen, Szymon, Surman, Marta, Rygielska, Monika, Ksiazek, Teofila, Pac, Agnieszka, Wieczorek, Aleksandra, Skalska-Sadowska, Jolanta, Samborska, Magdalena, Wachowiak, Jacek, Chaber, Radoslaw, Tomaszewska, Renata, Szczepanski, Tomasz, Zielezinska, Karolina, Urasinski, Tomasz, Moj-Hackemer, Malgorzata, Kalwak, Krzysztof, Kozlowska, Marta, and Irga-Jaworska, Ninela

Subjects
ACUTE myeloid leukemia, CHILDHOOD cancer, HEMATOPOIETIC stem cell transplantation, HEPATIC veno-occlusive disease, LIVER enzymes, BONE marrow
Abstract

Background: Gemtuzumab ozogamicin (GO), one of the first targeted drugs used in oncology, consists of an anti-cluster of differentiation 33 (CD33) monoclonal antibody bound to a derivative of cytotoxic calicheamicin. After the drug withdrawn in 2010 due to a significantly higher rate of early deaths, GO regained approval in 2017 for the treatment of newly diagnosed, refractory, or relapsed acute myeloid leukemia (AML) in adults and children over 15 years of age. The objective of the study was a retrospective analysis of clinical characteristics, treatment outcomes, and GO toxicity profile in children with primary refractory or relapsed (R/R) AML treated in Poland from 2008 to 2022. Methods: Data were collected through the Polish Registry of Acute Myeloid Leukemia. From January 2008 to December 2022, 35 children with R/R AML were treated with GO in seven centers of the Polish Pediatric Leukemia and Lymphoma Study Group. Results: Most of the children (30 of 35) received only one GO cycle in combination with various chemotherapy cycles (IDA-FLA, DOXO-FLA, FLA, FLAG, and others). Eighteen children (51%) achieved complete remission (CR), 14 did not respond to treatment, and three progressed. GO therapy was followed by allogeneic hematopoietic stem cell transplantation (allo-HSCT) in 18 children in CR. The 5-year overall survival (OS) after GO therapy was 37.1% ± 8.7% for the total cohort. There was a trend toward a superior outcome in patients with strong expression of CD33 expression (over 50% positive cells) compared with that in patients with lower expression of CD33 (OS, 41.2% ± 11.9% versus 27.8% ± 13.2%; p = 0.5; 5-year event-free survival, 35.4% ± 11.6% versus 25.7% ± 12.3%; p = 0.5, respectively). Children under 15 years have better outcome (OS, 34.9% ± 10.4% versus 30% ± 14.5%, p = 0.3). The most common adverse events were bone marrow aplasia, fever of unknown origin, infections, and elevated liver enzyme elevation. Sinusoidal obstruction syndrome occurred in two children. Conclusions: The use of GO in severely pretreated children, including those under 15 years of age, with previous failure of AML treatment is a feasible and effective bridging therapy to allo-HSCT with an acceptable toxicity profile. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Monitoring of the treatment with L-asparaginase in children with acute lymphoblastic leukemia – focus on silent inactivation and its influence on the treatment outcome

Author

Czogala, Malgorzata, primary, Rogatko, Iwona, additional, Pawińska-Wąsikowska, Katarzyna, additional, Czogała, Wojciech, additional, Bal, Wioletta, additional, Ciebiera, Małgorzata, additional, Chaber, Radosław, additional, Chodała-Grzywacz, Agnieszka, additional, Karolczyk, Grażyna, additional, Sztefko, Krystyna, additional, Balwierz, Walentyna, additional, and Skoczeń, Szymon, additional

Published
2022
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8. Development of treatment and clinical results in childhood acute myeloid leukemia in Poland

Author

Balwierz, Walentyna, Pawinska-Wasikowska, Katarzyna, Klekawka, Tomasz, Czogala, Malgorzata, Matysiak, Michal, Fic-Sikorska, Barbara, Adamkiewicz-Drozynska, Elzbieta, Maciejka-Kapuscinska, Lucyna, Chybicka, Alicja, Potocka, Kinga, Wachowiak, Jacek, Skalska-Sadowska, Jolanta, Kowalczyk, Jerzy, Wojcik, Beata, Wysocki, Mariusz, Koltan, Sylwia, Krawczuk-Rybak, Maryna, Muszynska-Roslan, Katarzyna, Mlynarski, Wojciech, Stolarska, Malgorzata, Urasinski, Tomasz, Kamienska, Elzbieta, Szczepanski, Tomasz, Tomaszewska, Renata, Sobol, Grazyna, Mizia-Malarz, Agnieszka, Karolczyk, Grazyna, Podhorecka, Joanna, Wieczorek, Maria, Karpinska-Derda, Irena, Badowska, Wanda, and Moryl-Bujakowska, Angelina

Published
2013
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9. Monitoring of treatment with L-asparaginase in children with acute lymphoblastic leukaemia, with a focus on silent inactivation and its influence on the treatment outcome.

Author

Czogala, Malgorzata, Rogatko, Iwona, Pawińska-Wąsikowska, Katarzyna, Czogała, Wojciech, Bal, Wioletta, Ciebiera, Małgorzata, Chaber, Radosław, Chodała-Grzywacz, Agnieszka, Karolczyk, Grażyna, Sztefko, Krystyna, Balwierz, Walentyna, and Skoczeń, Szymon

Subjects
*ASPARAGINASE, *LYMPHOBLASTIC leukemia, *ALLERGIES, *MEDICAL care, *HEALTH outcome assessment
Abstract

Introduction: The aim of the study was to analyse the frequency of silent inactivation and allergic reaction to asparaginase (ASP) and its impact on treatment results in patients with lymphoblastic leukaemia. Material and methods: Seventy patients with acute lymphoblastic leukaemia treated with ASP were enrolled in the study. Asparaginase activity was monitored. The patients were switched to another ASP formulation after allergy or inactivation. The treatment results were analysed. Results: Silent inactivation of native E. coli ASP was diagnosed in 5 patients (7%) and allergy in 34 patients (49%), and these patients were switched to pegylated ASP (PEG-ASP). Silent inactivation of PEG-ASP occurred in 8 patients (23%) and allergy in 6 patients (17%). Eight children continued therapy with Erwinase, and 4 did not switch to Erwinase after inactivation of PEGASP. Allergy to Erwinase occurred in 2 patients (22%); there was no inactivation. No significant differences in outcome were found between the groups of patients with and without allergy or silent inactivation of ASP. Due to regular monitoring and switching to other ASP preparations after allergy or silent inactivation, therapeutic activity was ensured in almost all patients. Conclusions: Monitoring of ASP activity is crucial to recognize silent inactivation and to guarantee treatment effectiveness by switching to other ASP preparations. [ABSTRACT FROM AUTHOR]

Published
2022
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10. High Frequency of Fusion Gene Transcript Resulting From t(10;11)(p12;q23) Translocation in Pediatric Acute Myeloid Leukemia in Poland

Author

Ksiazek, Teofila, primary, Czogala, Malgorzata, additional, Kaczowka, Przemyslaw, additional, Sadowska, Beata, additional, Pawinska-Wasikowska, Katarzyna, additional, Bik-Multanowski, Mirosław, additional, Sikorska-Fic, Barbara, additional, Matysiak, Michał, additional, Skalska-Sadowska, Jolanta, additional, Wachowiak, Jacek, additional, Rodziewicz-Konarska, Anna, additional, Chybicka, Alicja, additional, Muszynska-Rosłan, Katarzyna, additional, Krawczuk-Rybak, Maryna, additional, Grabowski, Dominik, additional, Kowalczyk, Jerzy, additional, Maciejka-Kemblowska, Lucyna, additional, Adamkiewicz-Drozynska, Elzbieta, additional, Mlynarski, Wojciech, additional, Tomaszewska, Renata, additional, Szczepanski, Tomasz, additional, Pohorecka, Joanna, additional, Karolczyk, Grazyna, additional, Mizia-Malarz, Agnieszka, additional, Mycko, Katarzyna, additional, Badowska, Wanda, additional, Zielezinska, Karolina, additional, Urasinski, Tomasz, additional, Karpinska-Derda, Irena, additional, Woszczyk, Mariola, additional, Ciebiera, Małgorzata, additional, Lejman, Monika, additional, Skoczen, Szymon, additional, and Balwierz, Walentyna, additional

Published
2020
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11. Retrospective Analysis of the Treatment Outcome in Myeloid Leukemia of Down Syndrome in Polish Pediatric Leukemia and Lymphoma Study Group From 2005 to 2019

Author

Czogala, Malgorzata, primary, Pawinska-Wasikowska, Katarzyna, additional, Ksiazek, Teofila, additional, Sikorska-Fic, Barbara, additional, Matysiak, Michal, additional, Skalska-Sadowska, Jolanta, additional, Wachowiak, Jacek, additional, Rodziewicz-Konarska, Anna, additional, Chybicka, Alicja, additional, Myszynska-Roslan, Katarzyna, additional, Krawczuk-Rybak, Maryna, additional, Grabowski, Dominik, additional, Kowalczyk, Jerzy, additional, Maciejka-Kemblowska, Lucyna, additional, Adamkiewicz-Drozynska, Elzbieta, additional, Bobeff, Katarzyna, additional, Mlynarski, Wojciech, additional, Tomaszewska, Renata, additional, Szczepanski, Tomasz, additional, Pohorecka, Joanna, additional, Chodala-Grzywacz, Agnieszka, additional, Karolczyk, Grazyna, additional, Mizia-Malarz, Agnieszka, additional, Mycko, Katarzyna, additional, Badowska, Wanda, additional, Zielezinska, Karolina, additional, Urasinski, Tomasz, additional, Nykiel, Magdalena, additional, Woszczyk, Mariola, additional, Ciebiera, Malgorzata, additional, Chaber, Radosław, additional, Skoczen, Szymon, additional, and Balwierz, Walentyna, additional

Published
2020
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12. Polymorphisms of SLC19A1 80 G>A, MTHFR 677 C>T, and Tandem TS Repeats Influence Pharmacokinetics, Acute Liver Toxicity, and Vomiting in Children With Acute Lymphoblastic Leukemia Treated With High Doses of Methotrexate

Author

Cwiklinska, Magdalena, primary, Czogala, Malgorzata, additional, Kwiecinska, Kinga, additional, Madetko-Talowska, Anna, additional, Szafarz, Malgorzata, additional, Pawinska, Katarzyna, additional, Wieczorek, Aleksandra, additional, Klekawka, Tomasz, additional, Rej, Magdalena, additional, Stepien, Konrad, additional, Halubiec, Przemyslaw, additional, Lazarczyk, Agnieszka, additional, Miklusiak, Karol, additional, Bik-Multanowski, Miroslaw, additional, Balwierz, Walentyna, additional, and Skoczen, Szymon, additional

Published
2020
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13. Unsatisfactory Outcome of Pediatric Relapsed and Refractory AML Treated with Clofarabine Combined with Topotecan, Vinorelbine and Thiotepa (TVTC)

Author

Skalska-Sadowska, Jolanta, primary, Pieczonka, Anna, additional, Smalisz-Skrzypczyk, Katarzyna, additional, Matysiak, Michal, additional, Muszynska-Roslan, Katarzyna, additional, Krawczuk-Rybak, Maryna, additional, Drabko, Katarzyna, additional, Kowalczyk, Jerzy, additional, Czogala, Malgorzata, additional, Balwierz, Walentyna, additional, Karolczyk, Grazyna, additional, Karpinska-Derda, Irena, additional, Woszczyk, Mariola, additional, Szczepanski, Tomasz, additional, and Wachowiak, Jacek, additional

Published
2015
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14. Improvement of the Treatment Results in Childhood Acute Myeloid Leukemia in Poland from 1983 to 2017

Author

Balwierz, Walentyna, Czogala, Malgorzata, Pawinska-Wasikowska, Katarzyna, Wachowiak, Jacek, Skalska-Sadowska, Jolanta, Matysiak, Michal, Szczepanski, Tomasz, Tomaszewska, Renata, Krawczuk-Rybak, Maryna, Muszynska-Roslan, Katarzyna, Kowalczyk, Jerzy R., Wisniewska-Slusarz, Hanna, Mlynarski, Wojciech, Chybicka, Alicja, Rodziewicz, Anna, Urasinski, Tomasz, Adamkiewicz-Drozynska, Elzbieta, Maciejka-Kemblowska, Lucyna, Karolczyk, Grazyna, Karpinska-Derda, Irena, Przybyszewski, Borys, Malarz-Mizia, Agnieszka, Koltan, Sylwia, and Chaber, Radoslaw

Published
2017
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15. Development of treatment and clinical results in childhood acute myeloid leukemia in Poland

Author

Balwierz, Walentyna, primary, Pawinska-Wasikowska, Katarzyna, additional, Klekawka, Tomasz, additional, Czogala, Malgorzata, additional, Matysiak, Michal, additional, Fic-Sikorska, Barbara, additional, Adamkiewicz-Drozynska, Elzbieta, additional, Maciejka-Kapuscinska, Lucyna, additional, Chybicka, Alicja, additional, Potocka, Kinga, additional, Wachowiak, Jacek, additional, Skalska-Sadowska, Jolanta, additional, Kowalczyk, Jerzy, additional, Wojcik, Beata, additional, Wysocki, Mariusz, additional, Koltan, Sylwia, additional, Krawczuk-Rybak, Maryna, additional, Muszynska-Roslan, Katarzyna, additional, Mlynarski, Wojciech, additional, Stolarska, Malgorzata, additional, Urasinski, Tomasz, additional, Kamienska, Elzbieta, additional, Szczepanski, Tomasz, additional, Tomaszewska, Renata, additional, Sobol, Grazyna, additional, Mizia-Malarz, Agnieszka, additional, Karolczyk, Grazyna, additional, Podhorecka, Joanna, additional, Wieczorek, Maria, additional, Karpinska-Derda, Irena, additional, Badowska, Wanda, additional, and Moryl-Bujakowska, Angelina, additional

Published
2012
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16. Improvement of the Treatment Results in Childhood Acute Myeloid Leukemia in Poland from 1983 to 2017

Author

Balwierz, Walentyna, Czogala, Malgorzata, Pawinska-Wasikowska, Katarzyna, Wachowiak, Jacek, Skalska-Sadowska, Jolanta, Michał Matysiak, Szczepanski, Tomasz, Tomaszewska, Renata, Krawczuk-Rybak, Maryna, Muszynska-Roslan, Katarzyna, Kowalczyk, Jerzy R., Wisniewska-Slusarz, Hanna, Mlynarski, Wojciech, Chybicka, Alicja, Rodziewicz, Anna, Urasinski, Tomasz, Adamkiewicz-Drozynska, Elzbieta, Maciejka-Kemblowska, Lucyna, Karolczyk, Grazyna, Karpinska-Derda, Irena, Przybyszewski, Borys, Malarz-Mizia, Agnieszka, Koltan, Sylwia, and Chaber, Radoslaw

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