1. Loss of FEV1 in cystic fibrosis: correlation with HRCT features
- Author
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David M. Hansell, Anastasia Oikonomou, Athol U. Wells, Paraskevi Karagianni, S. C. Efremidis, John Manavis, John Tsanakas, and Frederica Papadopoulou
- Subjects
Adult ,Male ,Pulmonary Atelectasis ,medicine.medical_specialty ,Tomography, X-Ray Computed/methods ,Adolescent ,Cystic Fibrosis ,Bronchiectasis/radiography ,Cystic fibrosis ,Pulmonary function testing ,Correlation ,Forced Expiratory Volume ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,In patient ,Child ,Lung ,Pulmonary Atelectasis/radiography ,Univariate analysis ,Bronchial wall ,Bronchiectasis ,business.industry ,General Medicine ,respiratory system ,medicine.disease ,respiratory tract diseases ,Cystic Fibrosis/physiopathology/*radiography ,Lung/physiopathology/radiography ,Female ,Radiology ,Tomography, X-Ray Computed ,business ,Perfusion - Abstract
The purpose of this study was to determine which high-resolution computed tomography (HRCT) features in patients with cystic fibrosis are most strongly associated with functional impairment as expressed by forced expiratory volume in one second (FEV1). Forty-seven patients with cystic fibrosis underwent chest HRCT and had pulmonary function tests. The HRCT examinations were evaluated for 11 features scored using a modification of Bhalla system and FEV1 was recorded as percentage of the predicted value. Univariate and multivariate correlations between HRCT scores and FEV1 were performed. The most common HRCT feature was bronchiectasis (98%) followed by atelectasis-consolidation (81%), bronchial wall thickening (77%), tree-in-bud sign (74%), mucous plugging (72%) and mosaic perfusion pattern (47%). On univariate analysis the following features correlated strongly with FEV1: bronchial wall thickening ( p
- Published
- 2002
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