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206 results on '"Cyrta, Joanna"'

1. Tumor mutational burden assessment and standardized bioinformatics approach using custom NGS panels in clinical routine

Author

Dupain, Célia, Gutman, Tom, Girard, Elodie, Kamoun, Choumouss, Marret, Grégoire, Castel-Ajgal, Zahra, Sablin, Marie-Paule, Neuzillet, Cindy, Borcoman, Edith, Hescot, Ségolène, Callens, Céline, Trabelsi-Grati, Olfa, Melaabi, Samia, Vibert, Roseline, Antonio, Samantha, Franck, Coralie, Galut, Michèle, Guillou, Isabelle, Halladjian, Maral, Allory, Yves, Cyrta, Joanna, Romejon, Julien, Frouin, Eleonore, Stoppa-Lyonnet, Dominique, Wong, Jennifer, Le Tourneau, Christophe, Bièche, Ivan, Servant, Nicolas, Kamal, Maud, and Masliah-Planchon, Julien

Published
2024
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3. Alveolar soft part sarcomas in young patients: The French national NETSARC+ network experience

Author

Genevois, Anne-Laure, Carton, Matthieu, Jean-Denis, Myriam, Cyrta, Joanna, Corradini, Nadège, Metayer, Lucy, Chemin-Airiau, Claire, Karanian, Marie, Dufresne, Armelle, Pannier, Stéphanie, El Zein, Sophie, Defachelles, Anne-Sophie, Bompas, Emmanuelle, Gantzer, Justine, Honoré, Charles, Noal, Sabine, Héritier, Sébastien, Guillemet, Cécile, Serre, Jill, Le Loarer, François, Pierron, Gaëlle, Merlin, Marie-Sophie, Anract, Philippe, Gomez-Mascard, Anne, Llacer, Carmen, Ducimetière, Françoise, Toulmonde, Maud, Blay, Jean-Yves, and Orbach, Daniel

Published
2024
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4. Leiomyosarcoma and liposarcoma in young patients: The national netsarc+ network experience

Author

Genevois, Anne-Laure, Carton, Matthieu, Jean-Denis, Myriam, Cyrta, Joanna, Corradini, Nadège, Berlanga, Pablo, Chemin-Airiau, Claire, Honore, Charles, El Zein, Sophie, Defachelles, Anne-Sophie, Bompas, Emmanuelle, Anract, Philippe, Gantzer, Justine, Karanian, Marie, Rome, Angélique, Duffaud, Florence, Chevreau, Christine, Watson, Sarah, Le Cesne, Axel, Llacer, Carmen, Le Loarer, François, Pierron, Gaëlle, Gouin, François, Gomez-Mascard, Anne, Causeret, Sylvain, Ducimetière, Françoise, Kalbacher, Elsa, Toulmonde, Maud, Blay, Jean-Yves, and Orbach, Daniel

Published
2023
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5. Phase Ib/II trial of tipapkinogene sovacivec, a therapeutic human papillomavirus16-vaccine, in combination with avelumab in patients with advanced human papillomavirus16-positive cancers

Author

Borcoman, Edith, Lalanne, Ana, Delord, Jean-Pierre, Cassier, Philippe A., Rolland, Frédéric, Salas, Sébastien, Limacher, Jean-Marc, Capitain, Olivier, Lantz, Olivier, Ekwegbara, Christina, Jeannot, Emmanuelle, Cyrta, Joanna, Tran-Perennou, Carine, Castel-Ajgal, Zahra, Marret, Grégoire, Piaggio, Eliane, Brandely, Maud, Tavernaro, Annette, Makhloufi, Hakim, Bendjama, Kaidre, and Le Tourneau, Christophe

Published
2023
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6. Breast carcinomas with osteoclast-like giant cells: a comprehensive clinico-pathological and molecular portrait and evidence of RANK-L expression

Author

Cyrta, Joanna, Benoist, Camille, Masliah-Planchon, Julien, Vieira, Andre F., Pierron, Gaëlle, Fuhrmann, Laetitia, Richardot, Camille, Caly, Martial, Leclere, Renaud, Mariani, Odette, Da Maia, Elisabeth, Larousserie, Frédérique, Féron, Jean Guillaume, Carton, Matthieu, Renault, Victor, Bidard, François-Clément, and Vincent-Salomon, Anne

Published
2022
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8. Alterations in homologous recombination repair genes in prostate cancer brain metastases

Author

Rodriguez-Calero, Antonio, Gallon, John, Akhoundova, Dilara, Maletti, Sina, Ferguson, Alison, Cyrta, Joanna, Amstutz, Ursula, Garofoli, Andrea, Paradiso, Viola, Tomlins, Scott A., Hewer, Ekkehard, Genitsch, Vera, Fleischmann, Achim, Vassella, Erik, Rushing, Elisabeth J., Grobholz, Rainer, Fischer, Ingeborg, Jochum, Wolfram, Cathomas, Gieri, Osunkoya, Adeboye O., Bubendorf, Lukas, Moch, Holger, Thalmann, George, Ng, Charlotte K. Y., Gillessen, Silke, Piscuoglio, Salvatore, and Rubin, Mark A.

Published
2022
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9. Expanding the clinicopathologic spectrum and genomic landscape of tumors with SMARCA2/4::CREM fusions.

Author

Cyrta, Joanna, Dermawan, Josephine K, Tauziède‐Espariat, Arnault, Liu, Ting, Rosenblum, Marc, Shroff, Seema, Katabi, Nora, Cardoen, Liesbeth, Guillemot, Delphine, Masliah‐Planchon, Julien, Hoare, Owen, Delattre, Olivier, Bale, Tejus, Bourdeaut, Franck, and Antonescu, Cristina R

Subjects
SOFT tissue tumors, TUMORS in children, GENE fusion, YOUNG adults, LYMPHATIC metastasis
Abstract

CREB gene family (ATF1, CREB1, CREM) fusions with either EWSR1 or FUS gene partners drive the pathogenesis of a wide range of neoplasms, including various soft tissue tumors, intracranial myxoid mesenchymal tumors (IMMTs), hyalinizing clear cell carcinoma (HCCC), and rare mesotheliomas. Recently, a SMARCA2::CREM fusion was reported in one case each of IMMT and HCCC. In this study, we expand the clinicopathologic and molecular spectrum of these neoplasms by describing three additional cases with SMARCA2::CREM and one with a novel SMARCA4::CREM fusion, highlighting the recurrent potential of additional CREB gene fusion partners beyond FET family members. To evaluate if these fusions define a new pathologic entity, we performed a comprehensive genomic and methylation analysis and compared the results to other related tumors. Tumors occurred in children and young adults (median age 20 years) and spanned a broad anatomic distribution, including soft tissue, intracranial, head and neck, and prostatic urethra. Microscopically, the tumors shared an undifferentiated round to epithelioid cell phenotype and a hyalinized fibrous stroma. Immunohistochemically, a polyphenotypic profile was observed, with variable expression of SOX10, desmin, and/or epithelial markers. No targetable genomic alterations were found using panel‐based DNA sequencing. By DNA methylation and transcriptomic analyses, tumors grouped closely to FET::CREB entities, but not with SMARCA4/SMARCB1‐deficient tumors. High expression of CREM by immunohistochemistry was also documented in these tumors. Patients experienced local recurrence (n = 2), locoregional lymph node metastases (n = 2), and an isolated visceral metastasis (n = 1). Overall, our study suggests that SMARCA2/4::CREM fusions define a distinct group of neoplasms with round cell to epithelioid histology, a variable immunoprofile, and a definite risk of malignancy. Larger studies are needed to further explore the pathogenetic relationship with the FET::CREB family of tumors. © 2024 The Pathological Society of Great Britain and Ireland. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Genomic correlates of clinical outcome in advanced prostate cancer

Author

Abida, Wassim, Cyrta, Joanna, Heller, Glenn, Prandi, Davide, Armenia, Joshua, Coleman, Ilsa, Cieslik, Marcin, Benelli, Matteo, Robinson, Dan, Van Allen, Eliezer M., Sboner, Andrea, Fedrizzi, Tarcisio, Mosquera, Juan Miguel, Robinson, Brian D., De Sarkar, Navonil, Kunju, Lakshmi P., Tomlins, Scott, Wu, Yi Mi, Rodrigues, Daniel Nava, Loda, Massimo, Gopalan, Anuradha, Reuter, Victor E., Pritchard, Colin C., Mateo, Joaquin, Bianchini, Diletta, Miranda, Susana, Carreira, Suzanne, Rescigno, Pasquale, Filipenko, Julie, Vinson, Jacob, Montgomery, Robert B., Beltran, Himisha, Heath, Elisabeth I., Scher, Howard I., Kantoff, Philip W., Taplin, Mary-Ellen, Schultz, Nikolaus, deBono, Johann S., Demichelis, Francesca, Nelson, Peter S., Rubin, Mark A., Chinnaiyan, Arul M., and Sawyers, Charles L.

Published
2019

14. Molecular characterisation of tumours of the lacrimal apparatus

Author

Vibert, Roseline, primary, Cyrta, Joanna, additional, Girard, Elodie, additional, Vacher, Sophie, additional, Dupain, Célia, additional, Antonio, Samantha, additional, Wong, Jennifer, additional, Baulande, Sylvain, additional, De Sousa, Juliana Monteiro Ferras, additional, Vincent‐Salomon, Anne, additional, Masliah‐Planchon, Julien, additional, Girard, Nicolas, additional, Le Tourneau, Christophe, additional, Kamal, Maud, additional, and Bièche, Ivan, additional

Published
2023
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17. FIGURE 1 from The Identification of CELSR3 and Other Potential Cell Surface Targets in Neuroendocrine Prostate Cancer

Author

Van Emmenis, Lucie, primary, Ku, Sheng-Yu, primary, Gayvert, Kaitlyn, primary, Branch, Jonathan R., primary, Brady, Nicholas J., primary, Basu, Subhasree, primary, Russell, Michael, primary, Cyrta, Joanna, primary, Vosoughi, Aram, primary, Sailer, Verena, primary, Alnajar, Hussein, primary, Dardenne, Etienne, primary, Koumis, Elena, primary, Puca, Loredana, primary, Robinson, Brian D., primary, Feldkamp, Michael D., primary, Winkis, Annmarie, primary, Majewski, Nathan, primary, Rupnow, Brent, primary, Gottardis, Marco M., primary, Elemento, Olivier, primary, Rubin, Mark A., primary, Beltran, Himisha, primary, and Rickman, David S., primary

Published
2023
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18. Supplementary Figure 1 from The Identification of CELSR3 and Other Potential Cell Surface Targets in Neuroendocrine Prostate Cancer

Author

Van Emmenis, Lucie, primary, Ku, Sheng-Yu, primary, Gayvert, Kaitlyn, primary, Branch, Jonathan R., primary, Brady, Nicholas J., primary, Basu, Subhasree, primary, Russell, Michael, primary, Cyrta, Joanna, primary, Vosoughi, Aram, primary, Sailer, Verena, primary, Alnajar, Hussein, primary, Dardenne, Etienne, primary, Koumis, Elena, primary, Puca, Loredana, primary, Robinson, Brian D., primary, Feldkamp, Michael D., primary, Winkis, Annmarie, primary, Majewski, Nathan, primary, Rupnow, Brent, primary, Gottardis, Marco M., primary, Elemento, Olivier, primary, Rubin, Mark A., primary, Beltran, Himisha, primary, and Rickman, David S., primary

Published
2023
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19. Supplementary Data Legends from The Identification of CELSR3 and Other Potential Cell Surface Targets in Neuroendocrine Prostate Cancer

Author

Van Emmenis, Lucie, primary, Ku, Sheng-Yu, primary, Gayvert, Kaitlyn, primary, Branch, Jonathan R., primary, Brady, Nicholas J., primary, Basu, Subhasree, primary, Russell, Michael, primary, Cyrta, Joanna, primary, Vosoughi, Aram, primary, Sailer, Verena, primary, Alnajar, Hussein, primary, Dardenne, Etienne, primary, Koumis, Elena, primary, Puca, Loredana, primary, Robinson, Brian D., primary, Feldkamp, Michael D., primary, Winkis, Annmarie, primary, Majewski, Nathan, primary, Rupnow, Brent, primary, Gottardis, Marco M., primary, Elemento, Olivier, primary, Rubin, Mark A., primary, Beltran, Himisha, primary, and Rickman, David S., primary

Published
2023
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20. Supplementary Table 1 from The Identification of CELSR3 and Other Potential Cell Surface Targets in Neuroendocrine Prostate Cancer

Author

Van Emmenis, Lucie, primary, Ku, Sheng-Yu, primary, Gayvert, Kaitlyn, primary, Branch, Jonathan R., primary, Brady, Nicholas J., primary, Basu, Subhasree, primary, Russell, Michael, primary, Cyrta, Joanna, primary, Vosoughi, Aram, primary, Sailer, Verena, primary, Alnajar, Hussein, primary, Dardenne, Etienne, primary, Koumis, Elena, primary, Puca, Loredana, primary, Robinson, Brian D., primary, Feldkamp, Michael D., primary, Winkis, Annmarie, primary, Majewski, Nathan, primary, Rupnow, Brent, primary, Gottardis, Marco M., primary, Elemento, Olivier, primary, Rubin, Mark A., primary, Beltran, Himisha, primary, and Rickman, David S., primary

Published
2023
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21. FIGURE 5 from The Identification of CELSR3 and Other Potential Cell Surface Targets in Neuroendocrine Prostate Cancer

Author

Van Emmenis, Lucie, primary, Ku, Sheng-Yu, primary, Gayvert, Kaitlyn, primary, Branch, Jonathan R., primary, Brady, Nicholas J., primary, Basu, Subhasree, primary, Russell, Michael, primary, Cyrta, Joanna, primary, Vosoughi, Aram, primary, Sailer, Verena, primary, Alnajar, Hussein, primary, Dardenne, Etienne, primary, Koumis, Elena, primary, Puca, Loredana, primary, Robinson, Brian D., primary, Feldkamp, Michael D., primary, Winkis, Annmarie, primary, Majewski, Nathan, primary, Rupnow, Brent, primary, Gottardis, Marco M., primary, Elemento, Olivier, primary, Rubin, Mark A., primary, Beltran, Himisha, primary, and Rickman, David S., primary

Published
2023
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22. FIGURE 3 from The Identification of CELSR3 and Other Potential Cell Surface Targets in Neuroendocrine Prostate Cancer

Author

Van Emmenis, Lucie, primary, Ku, Sheng-Yu, primary, Gayvert, Kaitlyn, primary, Branch, Jonathan R., primary, Brady, Nicholas J., primary, Basu, Subhasree, primary, Russell, Michael, primary, Cyrta, Joanna, primary, Vosoughi, Aram, primary, Sailer, Verena, primary, Alnajar, Hussein, primary, Dardenne, Etienne, primary, Koumis, Elena, primary, Puca, Loredana, primary, Robinson, Brian D., primary, Feldkamp, Michael D., primary, Winkis, Annmarie, primary, Majewski, Nathan, primary, Rupnow, Brent, primary, Gottardis, Marco M., primary, Elemento, Olivier, primary, Rubin, Mark A., primary, Beltran, Himisha, primary, and Rickman, David S., primary

Published
2023
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23. Supplementary Figure 3 from The Identification of CELSR3 and Other Potential Cell Surface Targets in Neuroendocrine Prostate Cancer

Author

Van Emmenis, Lucie, primary, Ku, Sheng-Yu, primary, Gayvert, Kaitlyn, primary, Branch, Jonathan R., primary, Brady, Nicholas J., primary, Basu, Subhasree, primary, Russell, Michael, primary, Cyrta, Joanna, primary, Vosoughi, Aram, primary, Sailer, Verena, primary, Alnajar, Hussein, primary, Dardenne, Etienne, primary, Koumis, Elena, primary, Puca, Loredana, primary, Robinson, Brian D., primary, Feldkamp, Michael D., primary, Winkis, Annmarie, primary, Majewski, Nathan, primary, Rupnow, Brent, primary, Gottardis, Marco M., primary, Elemento, Olivier, primary, Rubin, Mark A., primary, Beltran, Himisha, primary, and Rickman, David S., primary

Published
2023
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24. FIGURE 4 from The Identification of CELSR3 and Other Potential Cell Surface Targets in Neuroendocrine Prostate Cancer

Author

Van Emmenis, Lucie, primary, Ku, Sheng-Yu, primary, Gayvert, Kaitlyn, primary, Branch, Jonathan R., primary, Brady, Nicholas J., primary, Basu, Subhasree, primary, Russell, Michael, primary, Cyrta, Joanna, primary, Vosoughi, Aram, primary, Sailer, Verena, primary, Alnajar, Hussein, primary, Dardenne, Etienne, primary, Koumis, Elena, primary, Puca, Loredana, primary, Robinson, Brian D., primary, Feldkamp, Michael D., primary, Winkis, Annmarie, primary, Majewski, Nathan, primary, Rupnow, Brent, primary, Gottardis, Marco M., primary, Elemento, Olivier, primary, Rubin, Mark A., primary, Beltran, Himisha, primary, and Rickman, David S., primary

Published
2023
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25. Supplementary Figure 2 from The Identification of CELSR3 and Other Potential Cell Surface Targets in Neuroendocrine Prostate Cancer

Author

Van Emmenis, Lucie, primary, Ku, Sheng-Yu, primary, Gayvert, Kaitlyn, primary, Branch, Jonathan R., primary, Brady, Nicholas J., primary, Basu, Subhasree, primary, Russell, Michael, primary, Cyrta, Joanna, primary, Vosoughi, Aram, primary, Sailer, Verena, primary, Alnajar, Hussein, primary, Dardenne, Etienne, primary, Koumis, Elena, primary, Puca, Loredana, primary, Robinson, Brian D., primary, Feldkamp, Michael D., primary, Winkis, Annmarie, primary, Majewski, Nathan, primary, Rupnow, Brent, primary, Gottardis, Marco M., primary, Elemento, Olivier, primary, Rubin, Mark A., primary, Beltran, Himisha, primary, and Rickman, David S., primary

Published
2023
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26. FIGURE 2 from The Identification of CELSR3 and Other Potential Cell Surface Targets in Neuroendocrine Prostate Cancer

Author

Van Emmenis, Lucie, primary, Ku, Sheng-Yu, primary, Gayvert, Kaitlyn, primary, Branch, Jonathan R., primary, Brady, Nicholas J., primary, Basu, Subhasree, primary, Russell, Michael, primary, Cyrta, Joanna, primary, Vosoughi, Aram, primary, Sailer, Verena, primary, Alnajar, Hussein, primary, Dardenne, Etienne, primary, Koumis, Elena, primary, Puca, Loredana, primary, Robinson, Brian D., primary, Feldkamp, Michael D., primary, Winkis, Annmarie, primary, Majewski, Nathan, primary, Rupnow, Brent, primary, Gottardis, Marco M., primary, Elemento, Olivier, primary, Rubin, Mark A., primary, Beltran, Himisha, primary, and Rickman, David S., primary

Published
2023
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27. Data from The Identification of CELSR3 and Other Potential Cell Surface Targets in Neuroendocrine Prostate Cancer

Author

Van Emmenis, Lucie, primary, Ku, Sheng-Yu, primary, Gayvert, Kaitlyn, primary, Branch, Jonathan R., primary, Brady, Nicholas J., primary, Basu, Subhasree, primary, Russell, Michael, primary, Cyrta, Joanna, primary, Vosoughi, Aram, primary, Sailer, Verena, primary, Alnajar, Hussein, primary, Dardenne, Etienne, primary, Koumis, Elena, primary, Puca, Loredana, primary, Robinson, Brian D., primary, Feldkamp, Michael D., primary, Winkis, Annmarie, primary, Majewski, Nathan, primary, Rupnow, Brent, primary, Gottardis, Marco M., primary, Elemento, Olivier, primary, Rubin, Mark A., primary, Beltran, Himisha, primary, and Rickman, David S., primary

Published
2023
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28. The Identification of CELSR3 and Other Potential Cell Surface Targets in Neuroendocrine Prostate Cancer

Author

Van Emmenis, Lucie, primary, Ku, Sheng-Yu, additional, Gayvert, Kaitlyn, additional, Branch, Jonathan R., additional, Brady, Nicholas J., additional, Basu, Subhasree, additional, Russell, Michael, additional, Cyrta, Joanna, additional, Vosoughi, Aram, additional, Sailer, Verena, additional, Alnajar, Hussein, additional, Dardenne, Etienne, additional, Koumis, Elena, additional, Puca, Loredana, additional, Robinson, Brian D., additional, Feldkamp, Michael D., additional, Winkis, Annmarie, additional, Majewski, Nathan, additional, Rupnow, Brent, additional, Gottardis, Marco M., additional, Elemento, Olivier, additional, Rubin, Mark A., additional, Beltran, Himisha, additional, and Rickman, David S., additional

Published
2023
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29. Fat-Containing Soft Tissue Tumors in Children, Adolescents, and Young Adults: Which Require Biopsy?

Author

Cardoen, Liesbeth, primary, Nicolas, Nayla, additional, Le Gaudu, Violette, additional, Gauthier, Arnaud, additional, Carton, Matthieu, additional, Berrebi, Dominique, additional, Cyrta, Joanna, additional, Collignon, Charlotte, additional, Cordero, Camille, additional, Pierron, Gaëlle, additional, Pannier, Stéphanie, additional, Philippe-Chomette, Pascale, additional, Orbach, Daniel, additional, and Brisse, Hervé J., additional

Published
2023
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30. Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity

Author

Cyrta, Joanna, Augspach, Anke, De Filippo, Maria Rosaria, Prandi, Davide, Thienger, Phillip, Benelli, Matteo, Cooley, Victoria, Bareja, Rohan, Wilkes, David, Chae, Sung-Suk, Cavaliere, Paola, Dephoure, Noah, Uldry, Anne-Christine, Lagache, Sophie Braga, Roma, Luca, Cohen, Sandra, Jaquet, Muriel, Brandt, Laura P., Alshalalfa, Mohammed, Puca, Loredana, Sboner, Andrea, Feng, Felix, Wang, Shangqian, Beltran, Himisha, Lotan, Tamara, Spahn, Martin, Kruithof-de Julio, Marianna, Chen, Yu, Ballman, Karla V., Demichelis, Francesca, Piscuoglio, Salvatore, and Rubin, Mark A.

Published
2020
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31. Abstract 3525: VGLL2-NCOA2 leverages developmental programs for pediatric sarcomagenesis

Author

Watson, Sarah, primary, LaVigne, Collette A., additional, Xu, Lin, additional, Surdez, Didier, additional, Cyrta, Joanna, additional, Calderon, Delia, additional, Cannon, Matthew V., additional, Kent, Matthew R., additional, Silvius, Katherine M., additional, Kucinski, Jack P., additional, Harrison, Emma N., additional, Murchison, Whitney, additional, Rakheja, Dinesh, additional, Tirode, Franck, additional, Delattre, Olivier, additional, Amatruda, James F., additional, and Kendall, Genevieve C., additional

Published
2023
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32. Abstract P6-04-07: Primary Diagnosis of Breast Biopsies supported by AI versus Microscope: Multi-Site Clinical Reader Study

Author

Salomon, Anne, primary, Nudelman, Alona, additional, Cyrta, Joanna, additional, Maklakovski, Marina, additional, Shach, Anat Albrecht, additional, Sebag, Geraldine, additional, Mallel, Giuseppe, additional, Krasnitsky, Ira, additional, Feinberg, Tali, additional, Vecsler, Manuela, additional, and Sandbank, Judith, additional

Published
2023
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33. Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling

Author

Robinson, Brian D., Vlachostergios, Panagiotis J., Bhinder, Bhavneet, Liu, Weisi, Li, Kailyn, Moss, Tyler J., Bareja, Rohan, Park, Kyung, Tavassoli, Peyman, Cyrta, Joanna, Tagawa, Scott T., Nanus, David M., Beltran, Himisha, Molina, Ana M., Khani, Francesca, Miguel Mosquera, Juan, Xylinas, Evanguelos, Shariat, Shahrokh F., Scherr, Douglas S., Rubin, Mark A., Lerner, Seth P., Matin, Surena F., Elemento, Olivier, and Faltas, Bishoy M.

Published
2019
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36. Whole-genome characterization of myoepithelial carcinomas of the soft tissue

Author

Cyrta, Joanna, primary, Rosiene, Joel, additional, Bareja, Rohan, additional, Kudman, Sarah, additional, Al Zoughbi, Wael, additional, Motanagh, Samaneh, additional, Wilkes, David C., additional, Eng, Kenneth, additional, Zhang, Tuo, additional, Sticca, Evan, additional, Mathew, Susan, additional, Rubin, Mark A., additional, Sboner, Andrea, additional, Elemento, Olivier, additional, Rubin, Brian P., additional, Imielinski, Marcin, additional, and Mosquera, Juan Miguel, additional

Published
2022
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38. Bone biopsy protocol for advanced prostate cancer in the era of precision medicine

Author

Sailer, Verena, Schiffman, Marc H., Kossai, Myriam, Cyrta, Joanna, Beg, Shaham, Sullivan, Brian, Pua, Bradley B., Lee, Kyungmouk Steve, Talenfeld, Adam D., Nanus, David M., Tagawa, Scott T., Robinson, Brian D., Rao, Rema A., Pauli, Chantal, Bareja, Rohan, Beltran, Luis S., Sigaras, Alexandros, Eng, Kenneth Wa, Elemento, Olivier, Sboner, Andrea, Rubin, Mark A., Beltran, Himisha, and Mosquera, Juan Miguel

Published
2018
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39. Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer

Author

Beltran, Himisha, Prandi, Davide, Mosquera, Juan Miguel, Benelli, Matteo, Puca, Loredana, Cyrta, Joanna, Marotz, Clarisse, Giannopoulou, Eugenia, Chakravarthi, Balabhadrapatruni V.S.K., Varambally, Sooryanarayana, Tomlins, Scott A., Nanus, David M., Tagawa, Scott T., Van Allen, Eliezer M., Elemento, Olivier, Sboner, Andrea, Garraway, Levi A., Rubin, Mark A., and Demichelis, Francesca

Subjects
Prostate cancer -- Analysis -- Health aspects -- Genetic aspects -- Care and treatment -- Patient outcomes -- Research, Hormone receptors -- Physiological aspects -- Genetic aspects -- Research, Androgens -- Physiological aspects -- Genetic aspects -- Research, Biological sciences, Health
Abstract

An increasingly recognized resistance mechanism to androgen receptor (AR)-directed therapy in prostate cancer involves epithelial plasticity, in which tumor cells demonstrate low to absent AR expression and often have neuroendocrine features. The etiology and molecular basis for this 'alternative' treatment-resistant cell state remain incompletely understood. Here, by analyzing whole-exome sequencing data of metastatic biopsies from patients, we observed substantial genomic overlap between castration-resistant tumors that were histologically characterized as prostate adenocarcinomas (CRPC-Adeno) and neuroendocrine prostate cancer (CRPC-NE); analysis of biopsy samples from the same individuals over time points to a model most consistent with divergent clonal evolution. Genome-wide DNA methylation analysis revealed marked epigenetic differences between CRPC-NE tumors and CRPC-Adeno, and also designated samples of CRPC-Adeno with clinical features of AR independence as CRPC-NE, suggesting that epigenetic modifiers may play a role in the induction and/or maintenance of this treatment-resistant state. This study supports the emergence of an alternative, 'AR-indifferent' cell state through divergent clonal evolution as a mechanism of treatment resistance in advanced prostate cancer., Prostate cancer remains a leading cause of cancer death in males worldwide (1). The mainstay of therapy for patients with metastatic spread, including castration-resistant disease, is hormonal therapy that targets [...]

Published
2016

40. Comparative genomics of primary prostate cancer and paired metastases: insights from 12 molecular case studies

Author

Cyrta, Joanna, primary, Prandi, Davide, additional, Arora, Arshi, additional, Hovelson, Daniel H, additional, Sboner, Andrea, additional, Rodriguez, Antonio, additional, Fedrizzi, Tarcisio, additional, Beltran, Himisha, additional, Robinson, Dan R, additional, Gopalan, Anuradha, additional, True, Lawrence, additional, Nelson, Peter S, additional, Robinson, Brian D, additional, Mosquera, Juan Miguel, additional, Tomlins, Scott A, additional, Shen, Ronglai, additional, Demichelis, Francesca, additional, and Rubin, Mark A, additional

Published
2022
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42. Harbingers of Aggressive Prostate Cancer: Precision Oncology Case Studies

Author

Cyrta, Joanna, primary, Prandi, Davide, additional, Arora, Arshi, additional, Hovelson, Daniel H., additional, Sboner, Andrea, additional, Rodriguez, Antonio, additional, Fedrizzi, Tarcisio, additional, Beltran, Himisha, additional, Robinson, Dan R., additional, Gopalan, Anuradha, additional, True, Lawrence, additional, Nelson, Peter, additional, Robinson, Brian D., additional, Mosquera, Juan Miguel, additional, Tomlins, Scott, additional, Shen, Ronglai, additional, Demichelis, Francesca S., additional, and Rubin, Mark, additional

Published
2021
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43. Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

Author

Sistigu, Antonella, Yamazaki, Takahiro, Vacchelli, Erika, Chaba, Kariman, Enot, David P, Adam, Julien, Vitale, Ilio, Goubar, Aicha, Baracco, Elisa E, Remédios, Catarina, Fend, Laetitia, Hannani, Dalil, Aymeric, Laetitia, Ma, Yuting, Niso-Santano, Mireia, Kepp, Oliver, Schultze, Joachim L, Tüting, Thomas, Belardelli, Filippo, Bracci, Laura, La Sorsa, Valentina, Ziccheddu, Giovanna, Sestili, Paola, Urbani, Francesca, Delorenzi, Mauro, Lacroix-Triki, Magali, Quidville, Virginie, Conforti, Rosa, Spano, Jean-Philippe, Pusztai, Lajos, Poirier-Colame, Vichnou, Delaloge, Suzette, Penault-Llorca, Frederique, Ladoire, Sylvain, Arnould, Laurent, Cyrta, Joanna, Dessoliers, Marie-Charlotte, Eggermont, Alexander, Bianchi, Marco E, Pittet, Mikael, Engblom, Camilla, Pfirschke, Christina, Préville, Xavier, Uzè, Gilles, Schreiber, Robert D, Chow, Melvyn T, Smyth, Mark J, Proietti, Enrico, André, Fabrice, Kroemer, Guido, and Zitvogel, Laurence

Published
2014
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44. Next‐generation sequencing in breast pathology: real impact on routine practice over a decade since its introduction.

Author

Nourieh, Maya, Vibert, Roseline, Saint‐Ghislain, Mathilde, Cyrta, Joanna, and Vincent‐Salomon, Anne

Subjects
BREAST, EPIDERMAL growth factor receptors, NUCLEOTIDE sequencing, MOLECULAR pathology, BRCA genes, PATHOLOGY, BREAST cancer prognosis, CANCER relapse
Abstract

The diagnosis, histomolecular classes of breast cancers (luminal A, luminal B, HER2‐enriched, and basal‐like), and accurate prediction of prognosis are commonly determined using morphological and phenotypical analyses in clinical practice worldwide. Therapeutic strategies are mostly based on the disease stage and molecular subclasses of breast cancer. Targeted therapies, such as anti‐HER2s, poly‐ADP ribose polymerase inhibitors or, to a lesser extent, phosphatidylinositol 3 kinase inhibitors, have substantially improved breast cancer patient prognosis over the past decades. Human epidermal growth factor receptor 2 (HER2) overexpression is widely determined based on immunohistochemistry, while next‐generation sequencing (NGS) is currently employed to assess the presence of molecular alterations, including breast cancer gene 1 (BRCA1) and 2 or phosphatidylinositol‐4,5‐bisphosphate 3‐kinase catalytic subunit alpha (PIK3CA) mutations, which are targets of these new approved therapies. In addition, next‐generation sequencing (NGS) can aid the pathologist in challenging situations, such as a diagnostic workup for a metastatic carcinoma in lymph nodes of unknown origin, differential diagnosis of spindle cell tumourtumor in the breast between metaplastic carcinoma, malignant PT and sarcoma, o, as well as determining relatedness between primary breast cancers and recurrences. NGS offers a powerful tool that enables the pathologist to combine morphological analyses together with molecular alterations in challenging diagnostic situations. [ABSTRACT FROM AUTHOR]

Published
2023
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45. Genomic landscape of adenoid cystic carcinoma of the breast

Author

Martelotto, Luciano G, De Filippo, Maria R, Ng, Charlotte KY, Natrajan, Rachael, Fuhrmann, Laetitia, Cyrta, Joanna, Piscuoglio, Salvatore, Wen, Huei-Chi, Lim, Raymond S, Shen, Ronglai, Schultheis, Anne M, Wen, Y Hannah, Edelweiss, Marcia, Mariani, Odette, Stenman, Göran, Chan, Timothy A, Colombo, Pierre-Emmanuel, Norton, Larry, Vincent-Salomon, Anne, Reis-Filho, Jorge S, and Weigelt, Britta

Published
2015
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46. SMARCA4 ‐deficient rhabdoid tumours show intermediate molecular features between SMARCB1 ‐deficient rhabdoid tumours and small cell carcinomas of the ovary, hypercalcaemic type

Author

Andrianteranagna, Mamy, primary, Cyrta, Joanna, additional, Masliah‐Planchon, Julien, additional, Nemes, Karolina, additional, Corsia, Alice, additional, Leruste, Amaury, additional, Holdhof, Dörthe, additional, Kordes, Uwe, additional, Orbach, Daniel, additional, Corradini, Nadège, additional, Entz‐Werle, Natacha, additional, Pierron, Gaëlle, additional, Castex, Marie‐Pierre, additional, Brouchet, Anne, additional, Weingertner, Noëlle, additional, Ranchère, Dominique, additional, Fréneaux, Paul, additional, Delattre, Olivier, additional, Bush, Jonathan, additional, Leary, Alexandra, additional, Frühwald, Michael C, additional, Schüller, Ulrich, additional, Servant, Nicolas, additional, and Bourdeaut, Franck, additional

Published
2021
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47. Infantile Rhabdomyosarcomas With VGLL2 Rearrangement Are Not Always an Indolent Disease

Author

Cyrta, Joanna, primary, Gauthier, Arnaud, additional, Karanian, Marie, additional, Vieira, Andre F., additional, Cardoen, Liesbeth, additional, Jehanno, Nina, additional, Bouvet, Mégane, additional, Bouvier, Corinne, additional, Komuta, Mina, additional, Le Loarer, François, additional, Orbach, Daniel, additional, Rome, Angélique, additional, Minard-Colin, Véronique, additional, Brichard, Bénédicte, additional, Pluchart, Claire, additional, Thebaud, Estelle, additional, Renard, Marleen, additional, Pannier, Stéphanie, additional, Brisse, Hervé, additional, Petit, Philippe, additional, Benoist, Camille, additional, Schleiermacher, Gudrun, additional, Geoerger, Birgit, additional, Vincent-Salomon, Anne, additional, Fréneaux, Paul, additional, and Pierron, Gaëlle, additional

Published
2021
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48. Le rôle ambigu du complexe SWI/SNF dans les cancers, illustré à travers deux exemples : les carcinomes à petites cellules de l’ovaire de type hypercalcémiant (SCCOHT) et le cancer de la prostate

Author

Cyrta, Joanna, STAR, ABES, Prédicteurs moléculaires et nouvelles cibles en oncologie (PMNCO), Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Université Paris-Saclay, and Jean-Yves Scoazec

Subjects
Smarca4, cells, genetic processes, Épigénétique, Prostate, [SDV.CAN]Life Sciences [q-bio]/Cancer, macromolecular substances, Sccoht, [SDV.GEN.GH] Life Sciences [q-bio]/Genetics/Human genetics, enzymes and coenzymes (carbohydrates), [SDV.CAN] Life Sciences [q-bio]/Cancer, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Epigenetics, biological phenomena, cell phenomena, and immunity, Swi/snf, Cancer
Abstract

The SWI/SNF chromatin remodeling complex is a major epigenetic regulator involved in embryonic development and in cell differentiation. In addition, genes encoding components of SWI/SNF are altered in at least 20% of cancers. Even though the SWI/SNF complex is usually regarded as a tumor suppressor, there is increasing evidence that the role of SWI/SNF in cancer may be tissue type- and context-dependent.In the first part of this dissertation, we present the molecular characterization of an independent cohort of small cell carcinomas of the ovary, hypercalcemic type (SCCOHT), as an example of a malignancy driven by loss-of-function alterations of the catalytic subunit of SWI/SNF, SMARCA4. In the second part, we explore the role of SWI/SNF in prostate cancer (PCa), including its most aggressive forms: castration-resistant prostate cancer and neuroendocrine prostate cancer. We show that while SWI/SNF mutations are exceedingly rare in PCa, the expression of several SWI/SNF subunits can be deregulated and that high SMARCA4 expression is associated with aggressive PCa. In addition, we show that many PCa cell lines are dependent on SWI/SNF for their growth.Taken together, these two examples further support the hypothesis that SWI/SNF can play different roles in cancer, depending on the tumor type., Le complexe de remodelage de la chromatine SWI/SNF est un régulateur épigénétique majeur impliqué dans le développement embryonnaire et dans la différentiation cellulaire. De plus, les gènes qui encodent les sous-unités de SWI/SNF sont altérés dans au moins 20% de cancers. Bien que le complexe SWI/SNF soit le plus souvent considéré comme suppresseur des tumeurs, il existe des preuves croissantes que le rôle de SWI/SNF dans le cancer peut dépendre du type de tissu et du contexte.Dans la première partie de cette dissertation, nous présentons la caractérisation moléculaire d’une cohorte indépendante de carcinomes à petites cellules de l’ovaire de type hypercalcémiant (SCCOHT), comme exemple d’un cancer sous-tendu par des altérations perte-de-fonction de la sous unité catalytique de SWI/SNF, SMARCA4. Dans la deuxième partie, nous explorons le rôle du SWI/SNF dans le cancer de la prostate (CP), y compris ses formes les plus agressives : le CP résistant à la castration et le carcinome neuroendocrine. Alors que les mutations des gènes de SWI/SNF sont très rares dans le CP, nous montrons que l’expression de certaines sous-unités peut être dérégulée et qu’une haute expression de SMARCA4 est associée à des CP agressifs. De plus, nous montrons que plusieurs lignées cellulaires de CP dépendent de SWI/SNF pour leur croissance.Au total, ces deux exemples supportent l’hypothèse que SWI/SNF peut jouer des rôles différents dans le cancer en fonction du type tumoral.

Published
2020

49. Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT) beyond SMARCA4 Mutations: A Comprehensive Genomic Analysis

Author

Auguste, Aurélie, primary, Blanc-Durand, Félix, additional, Deloger, Marc, additional, Le Formal, Audrey, additional, Bareja, Rohan, additional, Wilkes, David C., additional, Richon, Catherine, additional, Brunn, Béatrice, additional, Caron, Olivier, additional, Devouassoux-Shisheboran, Mojgan, additional, Gouy, Sébastien, additional, Morice, Philippe, additional, Bentivegna, Enrica, additional, Sboner, Andrea, additional, Elemento, Olivier, additional, Rubin, Mark A., additional, Pautier, Patricia, additional, Genestie, Catherine, additional, Cyrta, Joanna, additional, and Leary, Alexandra, additional

Published
2020
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50. The Genomic Landscape of Prostate Cancer Brain Metastases

Author

Rodriguez, Antonio, primary, Gallon, John, additional, Akhoundova, Dilara, additional, Maletti, Sina, additional, Ferguson, Alison, additional, Cyrta, Joanna, additional, Amstutz, Ursula, additional, Garofoli, Andrea, additional, Paradiso, Viola, additional, Tomlins, Scott A., additional, Hewer, Ekkehard, additional, Genitsch, Vera, additional, Fleischmann, Achim, additional, Rushing, Elisabeth J., additional, Grobholz, Rainer, additional, Fischer, Ingeborg, additional, Jochum, Wolfram, additional, Cathomas, Gieri, additional, Bubendorf, Lukas, additional, Moch, Holger, additional, Ng, Charlotte K.Y., additional, Sommer, Silke Gillessen, additional, Piscuoglio, Salvatore, additional, and Rubin, Mark A., additional

Published
2020
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