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3. [68Ga]Ga-FAPI-46 PET/CT for penile cancer – a feasibility study

Author

Eismann, Lennert, Ledderose, Stephan T., Enzinger, Benazir, Berg, Elena, Westhofen, Thilo, Rodler, Severin, Schulz, Gerald B., Toms, Johannes, Holzgreve, Adrien, Gildehaus, Franz J., Brendel, Matthias, Cyran, Clemens C., Unterrainer, Marcus, Stief, Christian G., Bartenstein, Peter, Schlenker, Boris, and Unterrainer, Lena M.

Published
2024
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6. [68 Ga]Ga-FAPI-46 PET/CT for locoregional lymph node staging in urothelial carcinoma of the bladder prior to cystectomy: initial experiences from a pilot analysis

Author

Unterrainer, Lena M., Eismann, Lennert, Lindner, Simon, Gildehaus, Franz-Josef, Toms, Johannes, Casuscelli, Jozefina, Holzgreve, Adrien, Kunte, Sophie C., Cyran, Clemens C., Menold, Paula, Karl, Alexander, Unterrainer, Marcus, Ledderose, Stephan T., Stief, Christian G., Bartenstein, Peter, Kretschmer, Alexander, and Schulz, Gerald B.

Published
2024
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10. Reliability and practicability of PSMA-RADS 1.0 for structured reporting of PSMA-PET/CT scans in prostate cancer patients

Author

Grawe, Freba, Blom, Franziska, Winkelmann, Michael, Burgard, Caroline, Schmid-Tannwald, Christine, Unterrainer, Lena M., Sheikh, Gabriel T., Pfitzinger, Paulo L., Kazmierczak, Philipp, Cyran, Clemens C., Ricke, Jens, Stief, Christian G., Bartenstein, Peter, Ruebenthaler, Johannes, Fabritius, Matthias P., and Geyer, Thomas

Published
2024
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11. Next-generation PET/CT imaging in meningioma—first clinical experiences using the novel SSTR-targeting peptide [18F]SiTATE

Author

Unterrainer, Marcus, Kunte, Sophie C., Unterrainer, Lena M., Holzgreve, Adrien, Delker, Astrid, Lindner, Simon, Beyer, Leonie, Brendel, Matthias, Kunz, Wolfgang G., Winkelmann, Michael, Cyran, Clemens C., Ricke, Jens, Jurkschat, Klaus, Wängler, Carmen, Wängler, Björn, Schirrmacher, Ralf, Belka, Claus, Niyazi, Maximilian, Tonn, Joerg-Christian, Bartenstein, Peter, and Albert, Nathalie L.

Published
2023
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13. Validation of the SSTR-RADS 1.0 for the structured interpretation of SSTR-PET/CT and treatment planning in neuroendocrine tumor (NET) patients

Author

Grawe, Freba, Ebner, Ricarda, Geyer, Thomas, Beyer, Leonie, Winkelmann, Michael, Sheikh, Gabriel T., Eschbach, Ralf, Schmid-Tannwald, Christine, Cyran, Clemens C., Ricke, Jens, Bartenstein, Peter, Heimer, Maurice M., Faggioni, Lorenzo, Spitzweg, Christine, Fabritius, Matthias P., Auernhammer, Christoph J., and Ruebenthaler, Johannes

Published
2023
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14. Attitudes and perceptions of radiologists towards online (virtual) oncologic multidisciplinary team meetings during the COVID-19 pandemic—a survey of the European Society of Oncologic Imaging (ESOI)

Author

Bonanno, Nathania, Cioni, Dania, Caruso, Damiano, Cyran, Clemens C., Dinkel, Julien, Fournier, Laure, Gourtsoyianni, Sofia, Hoffmann, Ralf-Thorsten, Laghi, Andrea, Martincich, Laura, Mayerhoefer, Marius E., Zamboni, Giulia A., Sala, Evis, Schlemmer, Heinz-Peter, Neri, Emanuele, and D’Anastasi, Melvin

Published
2023
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15. Correction to: Next‑generation PET/CT imaging in meningioma—first clinical experiences using the novel SSTR‑targeting peptide [18F]SiTATE

Author

Unterrainer, Marcus, Kunte, Sophie C., Unterrainer, Lena M., Holzgreve, Adrien, Delker, Astrid, Lindner, Simon, Beyer, Leonie, Brendel, Matthias, Kunz, Wolfgang G., Winkelmann, Michael, Cyran, Clemens C., Ricke, Jens, Jurkschat, Klaus, Wängler, Carmen, Wängler, Björn, Schirrmacher, Ralf, Belka, Claus, Niyazi, Maximilian, Tonn, Joerg‑Christian, Bartenstein, Peter, and Albert, Nathalie L.

Published
2023
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16. Feasibility of [68Ga]Ga-FAPI-46 PET/CT for detection of nodal and hematogenous spread in high-grade urothelial carcinoma

Author

Unterrainer, Lena M., Lindner, Simon, Eismann, Lennert, Casuscelli, Jozefina, Gildehaus, Franz-Josef, Bui, Vinh Ngoc, Albert, Nathalie L., Holzgreve, Adrien, Beyer, Leonie, Todica, Andrei, Brendel, Matthias, Cyran, Clemens C., Karl, Alexander, Stief, Christian G., Ledderose, Stephan T., Unterrainer, Marcus, Bartenstein, Peter, Wenter, Vera, and Kretschmer, Alexander

Published
2022
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17. Imaging of pancreatic neuroendocrine tumors

Author

Berger, Frank, primary, Ingenerf, Maria, additional, Auernhammer, Christoph J, additional, Cyran, Clemens, additional, Ebner, Ricarda, additional, Zacherl, Mathias, additional, Ricke, Jens, additional, and Schmid-Tannwald, Christine, additional

Published
2024
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19. Complicated Carotid Artery Plaques and Risk of Recurrent Ischemic Stroke or TIA

Author

Kopczak, Anna, Schindler, Andreas, Sepp, Dominik, Bayer-Karpinska, Anna, Malik, Rainer, Koch, Mia L., Zeller, Julia, Strecker, Christoph, Janowitz, Daniel, Wollenweber, Frank A., Hempel, Johann-Martin, Boeckh-Behrens, Tobias, Cyran, Clemens C., Helck, Andreas, Harloff, Andreas, Ziemann, Ulf, Poli, Sven, Poppert, Holger, Saam, Tobias, and Dichgans, Martin

Published
2022
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20. 68Ga-EMP-100 PET/CT—a novel ligand for visualizing c-MET expression in metastatic renal cell carcinoma—first in-human biodistribution and imaging results

Author

Mittlmeier, Lena M., Todica, Andrei, Gildehaus, Franz-Josef, Unterrainer, Marcus, Beyer, Leonie, Brendel, Matthias, Albert, Nathalie L., Ledderose, Stephan T., Vettermann, Franziska J., Schott, Melanie, Rodler, Severin, Marcon, Julian, Ilhan, Harun, Cyran, Clemens C., Stief, Christian G., Staehler, Michael, and Bartenstein, Peter

Published
2022
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23. [68Ga]Ga-FAPI-46 PET/CT for penile cancer – a feasibility study.

Author

Eismann, Lennert, Ledderose, Stephan T., Enzinger, Benazir, Berg, Elena, Westhofen, Thilo, Rodler, Severin, Schulz, Gerald B., Toms, Johannes, Holzgreve, Adrien, Gildehaus, Franz J., Brendel, Matthias, Cyran, Clemens C., Unterrainer, Marcus, Stief, Christian G., Bartenstein, Peter, Schlenker, Boris, and Unterrainer, Lena M.

Subjects
PENILE cancer, SURGICAL therapeutics, LYMPHATIC metastasis, TREATMENT delay (Medicine), LYMPH nodes, POSITRON emission tomography
Abstract

Purpose: Penile cancer is a rare entity and has a good prognosis in localized stage. Delayed surgical treatment of lymphatic disease is associated with poor overall survival but conventional imaging cannot detect occult lymph node metastasis sufficiently. Imaging cancer related fibroblasts has shown promising results as non-invasive staging tool in various tumor entities but has not yet been evaluated in penile cancer. Methods: In this single-center pilot study, patients planned for surgical treatment for penile cancer underwent preoperatively [68Ga]Ga-FAPI-46 PET/CT. Post-operative histopathology was compared to [68Ga]Ga-FAPI-46 PET/CT results. Results: From January 2022 to June 2022, a total number 11 patients with histopathologically proven penile cancer underwent surgery and received [68Ga]Ga-FAPI-46 PET/CT prior therapy. 8 primary tumor sites and 4 lymph node regions were analyzed. FAPI uptake was increased on primary tumor site (SUVmax 16.2 (9.1 – 25.8)). Histopathological proven lymph node regions showed highly increased FAPI uptakes (SUVmax 17.9 (16.4 – 23.5) on [68Ga]Ga-FAPI-46 PET/CT. Conclusion: In this first pilot cohort, there were no false-positive FAPI uptake which might allow the detection of occult lymph node metastasis by [68Ga]Ga-FAPI-46 PET/CT and might consequently lead to omitting lymph node regions during surgery that had no increased FAPI uptake pre-operatively. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Functional maturation and longitudinal imaging of intraportal neonatal porcine islet grafts in genetically diabetic pigs

Author

Pilz, Johanna, primary, Gloddek, Nicol, additional, Lindheimer, Felix, additional, Lindner, Magdalena J., additional, Puhr-Westerheide, Daniel, additional, Ümütlü, Muzzafer, additional, Cyran, Clemens, additional, Seidensticker, Max, additional, Lindner, Richard, additional, Kraetzl, Martin, additional, Renner, Simone, additional, Merkus, Daphne, additional, Teupser, Daniel, additional, Bartenstein, Peter, additional, Ziegler, Sibylle I., additional, Wolf, Eckhard, additional, and Kemter, Elisabeth, additional

Published
2024
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25. Dosimetry and optimal scan time of [18F]SiTATE-PET/CT in patients with neuroendocrine tumours

Author

Beyer, Leonie, Gosewisch, Astrid, Lindner, Simon, Völter, Friederike, Mittlmeier, Lena M., Tiling, Reinhold, Brendel, Matthias, Cyran, Clemens C., Unterrainer, Marcus, Rübenthaler, Johannes, Auernhammer, Christoph J., Spitzweg, Christine, Böning, Guido, Gildehaus, F. J., Jurkschat, Klaus, Wängler, Carmen, Wängler, Björn, Schirrmacher, Ralf, Wenter, Vera, Todica, Andrei, Bartenstein, Peter, and Ilhan, Harun

Published
2021
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28. [68 Ga]Ga-FAPI-46 PET/CT for locoregional lymph node staging in urothelial carcinoma of the bladder prior to cystectomy: initial experiences from a pilot analysis.

Author

Unterrainer, Lena M., Eismann, Lennert, Lindner, Simon, Gildehaus, Franz-Josef, Toms, Johannes, Casuscelli, Jozefina, Holzgreve, Adrien, Kunte, Sophie C., Cyran, Clemens C., Menold, Paula, Karl, Alexander, Unterrainer, Marcus, Ledderose, Stephan T., Stief, Christian G., Bartenstein, Peter, Kretschmer, Alexander, and Schulz, Gerald B.

Subjects
POSITRON emission tomography, TRANSITIONAL cell carcinoma, LYMPH nodes, UROTHELIUM, CYSTECTOMY, BLADDER, URINARY organs
Abstract

Introduction: [68 Ga]Ga-FAPI-46 PET/CT is a novel hybrid imaging method that previously showed additional diagnostic value in the assessment of distant urothelial carcinoma lesions. We hypothesized that patients with bladder cancer benefit from [68 Ga]Ga-FAPI-46 PET/CT prior to radical cystectomy for locoregional lymph node staging. Materials and methods: Eighteen patients underwent [68 Ga]Ga-FAPI-46 PET/CT for evaluation of lymph node (LN) status in predefined LN regions. Two hundred twenty-nine intraoperatively removed LN served as histopathological reference standard. Results: Urothelial carcinoma (UC) spread was found in ten LN in seven different regions (14.3%). Hereby, [68 Ga]Ga-FAPI-46 PET/CT was positive in four out of seven regions (57.1%) and showed significantly increased FAPI uptake compared to non-pathological regions. In the remaining three out of seven (42.9%) regions, [68 Ga]Ga-FAPI-46 PET/CT was rated negative since no pathological increased FAPI uptake was detected or the proximity of the urinary tract prevented a differentiation from physiological uptake. CT was inconspicuous in these three regions. In total, two FAP-positive LN regions were found without histopathological counterpart. Overall, sensitivity, specificity, positive predictive value, and negative predictive value were 57.1%, 95.2%, 66.7%, and 93.0% for PET imaging. Conclusion: In summary, this innovative [68 Ga]Ga-FAPI-46 PET/CT method showed high specificity and negative predictive value in patients with bladder UC with a future potential to optimize therapy planning. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Multislice PET/CT in Neuroendocrine Tumors

Author

Pöpperl, Gabriele, Cyran, Clemens, Kauczor, Hans-Ulrich, Series Editor, Parizel, Paul M., Series Editor, Peh, Wilfred C. G., Series Editor, Brady, Luther W., Honorary Editor, Lu, Jiade J., Series Editor, Nikolaou, Konstantin, editor, Bamberg, Fabian, editor, Laghi, Andrea, editor, and Rubin, Geoffrey D., editor

Published
2019
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31. Identification of impactful imaging biomarker: Clinical applications for breast and prostate carcinoma

Author

Bäuerle, Tobias, additional, Dietzel, Matthias, additional, Pinker, Katja, additional, Bonekamp, David, additional, Zhang, Kevin S., additional, Schlemmer, Heinz-Peter, additional, Bannas, Peter, additional, Cyran, Clemens C., additional, Eisenblätter, Michel, additional, Hilger, Ingrid, additional, Jung, Caroline, additional, Schick, Fritz, additional, Wegner, Franz, additional, and Kiessling, Fabian, additional

Published
2023
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34. Evaluation of a Novel Macromolecular Cascade-Polymer Contrast Medium for Dynamic Contrast-Enhanced MRI Monitoring of Antiangiogenic Bevacizumab Therapy in a Human Melanoma Model

Author

Cyran, Clemens C, Fu, Yanjun, Rogut, Victor, Chaopathomkul, Bundit, Wendland, Michael F, Shames, David M, and Brasch, Robert C

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Biomedical Imaging, Bioengineering, Clinical Research, Cancer, Angiogenesis Inhibitors, Animals, Antibodies, Monoclonal, Humanized, Antineoplastic Agents, Bevacizumab, Capsules, Cell Line, Tumor, Contrast Media, Drug Monitoring, Heterocyclic Compounds, Humans, Macromolecular Substances, Magnetic Resonance Imaging, Melanoma, Neovascularization, Pathologic, Organometallic Compounds, Polyethylene Glycols, Rats, Rats, Nude, Reproducibility of Results, Sensitivity and Specificity, Treatment Outcome, Dynamic MRI, gadolinium polyethylene glycol polymer contrast agent, human melanoma xenograft, bevacizumab, anti-angiogenesis effect, Clinical Sciences, Nuclear Medicine & Medical Imaging, Clinical sciences
Abstract

Rationale and objectivesTo assess the applicability of a novel macromolecular polyethylene glycol (PEG)-core gadolinium contrast agent for monitoring early antiangiogenic effects of bevacizumab using dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI).Materials and methodsAthymic rats (n = 26) implanted with subcutaneous human melanoma xenografts underwent DCE-MRI at 2.0 T using two different macromolecular contrast agents. The PEG core cascade polymer PEG12,000-Gen4-(Gd-DOTA)16, designed for clinical development, was compared to the prototype, animal-only, macromolecular contrast medium (MMCM) albumin-(Gd-DTPA)35. The treatment (n = 13) and control (n = 13) group was imaged at baseline and 24 hours after a single dose of bevacizumab (1 mg) or saline to quantitatively assess the endothelial-surface permeability constant (K(PS), μL⋅min⋅100 cm(3)) and the fractional plasma volume (fPV,%), using a two-compartment kinetic model.ResultsMean K(PS) values, assessed with PEG12,000-Gen4-(Gd-DOTA)16, declined significantly (P < .05) from 29.5 ± 10 μL⋅min⋅100 cm(3) to 10.4 ± 7.8 μL⋅min⋅100 cm(3) by 24 hours after a single dose of bevacizumab. In parallel, K(PS) values quantified using the prototype MMCM albumin-(Gd-DTPA)35 showed an analogous, significant decline (P < .05) in the therapy group. No significant effects were detected on tumor vascularity or on microcirculatory parameters in the control group between the baseline and the follow-up scan at 24 hours.ConclusionDCE-MRI enhanced with the novel MMCM PEG12,000-Gen4-(Gd-DOTA)16 was able to monitor the effects of bevacizumab on melanoma xenografts within 24 hours of a single application, validated by the prototype, animal-only albumin-(Gd-DTPA)35. PEG12,000-Gen4-(Gd-DOTA)16 may be a promising candidate for further clinical development as a macromolecular blood pool contrast MRI agent.

Published
2013

43. MP50-03 [ 68 Ga]Ga-FAPI-46 PET/CT PRIOR TO SURGERY IN SQUAMOUS PENILE CANCER – PRELIMINARY CLINICAL RESULTS

Author

Eismann, Lennert, primary, Toms, Johannes, additional, Holzgreve, Adrien, additional, Berg, Elena, additional, Schleifele, Maximilian, additional, Rodler, Severin, additional, Gildehaus, Franz-Josef, additional, Brendel, Matthias, additional, Albert, Nathalie, additional, Cyran, Clemens, additional, Kazmierczak, Philipp, additional, Kunz, Wolfgang, additional, Ledderose, Stephan, additional, Stief, Christian, additional, Bartenstein, Peter, additional, Unterrainer, Marcus, additional, Schlenker, Boris, additional, and Unterrainer, Lena, additional

Published
2023
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49. Next-generation PET/CT imaging in meningioma—first clinical experiences using the novel SSTR-targeting peptide [18F]SiTATE.

Author

Unterrainer, Marcus, Kunte, Sophie C., Unterrainer, Lena M., Holzgreve, Adrien, Delker, Astrid, Lindner, Simon, Beyer, Leonie, Brendel, Matthias, Kunz, Wolfgang G., Winkelmann, Michael, Cyran, Clemens C., Ricke, Jens, Jurkschat, Klaus, Wängler, Carmen, Wängler, Björn, Schirrmacher, Ralf, Belka, Claus, Niyazi, Maximilian, Tonn, Joerg-Christian, and Bartenstein, Peter

Subjects
COMPUTED tomography, PEPTIDES, MENINGIOMA, POSITRON emission tomography, BONE marrow, SOMATOSTATIN receptors
Abstract

Background: Somatostatin-receptor (SSTR)-targeted PET/CT provides important clinical information in addition to standard imaging in meningioma patients. [18F]SiTATE is a novel, 18F-labeled SSTR-targeting peptide with superior imaging properties according to preliminary data. We provide the first [18F]SiTATE PET/CT data of a large cohort of meningioma patients. Methods: Patients with known or suspected meningioma undergoing [18F]SiTATE PET/CT were included. Uptake intensity (SUV) of meningiomas, non-meningioma lesions, and healthy organs were assessed using a 50% isocontour volume of interest (VOI) or a spherical VOI, respectively. Also, trans-osseous extension on PET/CT was assessed. Results: A total of 107 patients with 117 [18F]SiTATE PET/CT scans were included. Overall, 231 meningioma lesions and 61 non-meningioma lesions (e.g., post-therapeutic changes) were analyzed. Physiological uptake was lowest in healthy brain tissue, followed by bone marrow, parotid, and pituitary (SUVmean 0.06 ± 0.04 vs. 1.4 ± 0.9 vs. 1.6 ± 1.0 vs. 9.8 ± 4.6; p < 0.001). Meningiomas showed significantly higher uptake than non-meningioma lesions (SUVmax 11.6 ± 10.6 vs. 4.0 ± 3.3, p < 0.001). Meningiomas showed significantly higher uptake than non-meningioma lesions (SUVmax 11.6±10.6 vs. 4.0±3.3, p<0.001). 93/231 (40.3%) meningiomas showed partial trans-osseous extension and 34/231 (14.7%) predominant intra-osseous extension. 59/231 (25.6%) meningioma lesions found on PET/CT had not been reported on previous standard imaging. Conclusion: This is the first PET/CT study using an 18F-labeled SSTR-ligand in meningioma patients: [18F]SiTATE provides extraordinary contrast in meningioma compared to healthy tissue and non-meningioma lesions, which leads to a high detection rate of so far unknown meningioma sites and osseous involvement. Having in mind the advantageous logistic features of 18F-labeled compared to 68Ga-labeled compounds (e.g., longer half-life and large-badge production), [18F]SiTATE has the potential to foster a widespread use of SSTR-targeted imaging in neuro-oncology. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Comparison of somatostatin receptor expression in patients with neuroendocrine tumours with and without somatostatin analogue treatment imaged with [18F]SiTATE

Author

Eschbach, Ralf S., primary, Hofmann, Markus, additional, Späth, Lukas, additional, Sheikh, Gabriel T., additional, Delker, Astrid, additional, Lindner, Simon, additional, Jurkschat, Klaus, additional, Wängler, Carmen, additional, Wängler, Björn, additional, Schirrmacher, Ralf, additional, Tiling, Reinhold, additional, Brendel, Matthias, additional, Wenter, Vera, additional, Dekorsy, Franziska J., additional, Zacherl, Mathias J., additional, Todica, Andrei, additional, Ilhan, Harun, additional, Grawe, Freba, additional, Cyran, Clemens C., additional, Unterrainer, Marcus, additional, Rübenthaler, Johannes, additional, Knösel, Thomas, additional, Paul, Tanja, additional, Boeck, Stefan, additional, Westphalen, Christoph Benedikt, additional, Spitzweg, Christine, additional, Auernhammer, Christoph J., additional, Bartenstein, Peter, additional, Unterrainer, Lena M., additional, and Beyer, Leonie, additional

Published
2023
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