264 results on '"Cyganek, Lukas"'
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2. The seventh international RASopathies symposium: Pathways to a cure—expanding knowledge, enhancing research, and therapeutic discovery
3. mtDNA analysis using Mitopore
4. Molecular and cellular evidence for the impact of a hypertrophic cardiomyopathy-associated RAF1 variant on the structure and function of contractile machinery in bioartificial cardiac tissues
5. Electrophysiological and calcium-handling development during long-term culture of human-induced pluripotent stem cell-derived cardiomyocytes
6. Preclinical evaluation of CRISPR-based therapies for Noonan syndrome caused by deep-intronic LZTR1 variants
7. A review of protocols for human iPSC culture, cardiac differentiation, subtype-specification, maturation, and direct reprogramming
8. A modern automated patch-clamp approach for high throughput electrophysiology recordings in native cardiomyocytes
9. Noninvasive analysis of contractility during identical maturations revealed two phenotypes in ventricular but not in atrial iPSC-CM
10. Management of Metadata Types in Basic Cardiological Research
11. Bi-allelic missense disease-causing variants in RPL3L associate neonatal dilated cardiomyopathy with muscle-specific ribosome biogenesis
12. TRPV1 activation and internalization is part of the LPS-induced inflammation in human iPSC-derived cardiomyocytes
13. Proteomic mapping of atrial and ventricular heart tissue in patients with aortic valve stenosis
14. Long-term follow-up of implantable cardioverter-defibrillators in Short QT syndrome
15. Flagellin-Induced Immune Response in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes
16. Atrial fibrillation-associated electrical remodelling in human induced pluripotent stem cell-derived atrial cardiomyocytes: a novel pathway for antiarrhythmic therapy development
17. Combining a tetracycline (Tet)-inducible gRNA system and CRISPRa for titratable and timely controlled enhancement of endogenous SHISA3 activation in human induced pluripotent stem cells (hiPSC)
18. Abstract P3134: Impaired Calcium Homeostasis Underlies Lamin A/C Mutation R331Q Associated Atrial Fibrillation
19. Abstract P3129: Strain-induced Cardiac Arrhythmias Caused By A Noonan Syndrome Mutation In Raf1 Can Be Suppressed By Modulation Of The Ras-mapk Pathway In Vitro
20. Metabolic switch from fatty acid oxidation to glycolysis in knock‐in mouse model of Barth syndrome
21. Estradiol protection against toxic effects of catecholamine on electrical properties in human-induced pluripotent stem cell derived cardiomyocytes
22. Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes
23. Generation of a genetically-modified induced pluripotent stem cell line harboring an oncogenic gene variant KRAS p.G12V
24. Generation of a genetically-modified induced pluripotent stem cell line harboring a Noonan syndrome-associated gene variant MRAS p.G23V
25. Induced pluripotent stem cells of patients with Tetralogy of Fallot reveal transcriptional alterations in cardiomyocyte differentiation
26. CRISPLD1: a novel conserved target in the transition to human heart failure
27. Intronic CRISPR Repair in a Preclinical Model of Noonan Syndrome–Associated Cardiomyopathy
28. Novel insights in the pathomechanism of Brugada syndrome and fever‐related type 1 ECG changes in a preclinical study using human‐induced pluripotent stem cell‐derived cardiomyocytes
29. LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome
30. Novel Insights in the Pathogenic Role of Fever and Inflammation in Brugada Syndrome - Study Using Gene-Edited Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes
31. Serum of patients with acute myocardial infarction prevents inflammation in iPSC-cardiomyocytes
32. Krüppel-like factor 15 expression dynamics with CRISPR-based gene activation controls cardiomyocyte remodeling in the failing heart
33. Functional Characterization of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells
34. Epigenetic mechanism of L-type calcium channel β-subunit downregulation in short QT human induced pluripotent stem cell-derived cardiomyocytes with CACNB2 mutation
35. A Preclinical Study on Brugada Syndrome with a CACNB2 Variant Using Human Cardiomyocytes from Induced Pluripotent Stem Cells
36. Transcriptional Effects of Candidate COVID-19 Treatments on Cardiac Myocytes
37. CRISPR/Cas9-mediated rescue of osteoclast function in a stem cell-based disease model for osteopetrosis
38. Antiarrhythmic Effects of Vernakalant in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes from a Patient with Short QT Syndrome Type 1
39. Recent Advances in Modeling Mitochondrial Cardiomyopathy Using Human Induced Pluripotent Stem Cells
40. Biodegradable Poly-��-Caprolactone Scaffolds with ECFCs and iMSCs for Tissue-Engineered Heart Valves
41. Stress-Activated Kinase Mitogen-Activated Kinase Kinase-7 Governs Epigenetics of Cardiac Repolarization for Arrhythmia Prevention
42. Patientenspezifische iPS-Zellen und deren Anwendung in der Herzforschung
43. A preclinical model of Brugada syndrome using CRISPR Repair in human cardiomyocytes from induced pluripotent stem cells: plattform for drug screening
44. Regulation of Ion Channel Function in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes by Cancer Cell Secretion Through DNA Methylation
45. Synergistic Adverse Effects of Azithromycin and Hydroxychloroquine on Human Cardiomyocytes at a Clinically Relevant Treatment Duration
46. Dopamine D1/D5 Receptor Signaling Is Involved in Arrhythmogenesis in the Setting of Takotsubo Cardiomyopathy
47. Single-cell transcription profiles in Bloom syndrome patients link BLM deficiency with altered condensin complex expression signatures
48. Alteration of myocardial structure and function in RAF1-associated Noonan syndrome: Insights from cardiac disease modeling based on patient-derived iPSCs
49. Biodegradable Poly-ε-Caprolactone Scaffolds with ECFCs and iMSCs for Tissue-Engineered Heart Valves
50. Deciphering the pathogenic role of a variant with uncertain significance for short QT and Brugada syndromes using gene-edited human-induced pluripotent stem cell-derived cardiomyocytes and preclinical drug screening
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