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1. TIR domains of plant immune receptors are 2',3'-cAMP/cGMP synthetases mediating cell death.

2. Putrescine and Its Metabolic Precursor Arginine Promote Biofilm and c-di-GMP Synthesis in Pseudomonas aeruginosa.

3. CsrA Enhances Cyclic-di-GMP Biosynthesis and Yersinia pestis Biofilm Blockage of the Flea Foregut by Alleviating Hfq-Dependent Repression of the hmsT mRNA.

4. Elevated Extracellular cGMP Produced after Exposure to Enterotoxigenic Escherichia coli Heat-Stable Toxin Induces Epithelial IL-33 Release and Alters Intestinal Immunity.

5. Plasmodium falciparum Guanylyl Cyclase-Alpha and the Activity of Its Appended P4-ATPase Domain Are Essential for cGMP Synthesis and Blood-Stage Egress.

6. Translation of HDAC6 PET Imaging Using [ 18 F]EKZ-001-cGMP Production and Measurement of HDAC6 Target Occupancy in Nonhuman Primates.

7. Structure of the active GGEEF domain of a diguanylate cyclase from Vibrio cholerae.

8. Natriuretic Peptides Attenuate Retinal Pathological Neovascularization Via Cyclic Guanosine Monophosphate Signaling in Pericytes and Astrocytes.

9. CRRL269.

10. Low-Dose Carbon Monoxide Inhibits Rhinovirus Replication in Human Alveolar and Airway Epithelial Cells.

11. Scale-Down Model Development in ambr systems: An Industrial Perspective.

12. Influence of the N-terminal segment and the PHY-tongue element on light-regulation in bacteriophytochromes.

13. Structural basis of DSF recognition by its receptor RpfR and its regulatory interaction with the DSF synthase RpfF.

14. Production of 8-nitro-cGMP in osteocytic cells and its upregulation by parathyroid hormone and prostaglandin E 2 .

15. A novel p.(Glu111Val) missense mutation in GUCA1A associated with cone-rod dystrophy leads to impaired calcium sensing and perturbed second messenger homeostasis in photoreceptors.

16. Enhanced bacterial mutualism through an evolved biofilm phenotype.

17. BUBR1 Insufficiency Is Correlated with eNOS Reduction Experimentally In Vitro and In Vivo , and in Gastric Cancer Tissue.

18. Cardiac unloading by LVAD support differentially influences components of the cGMP-PKG signaling pathway in ischemic and dilated cardiomyopathy.

19. Measurement of cGMP-generating and -degrading activities and cGMP levels in cells and tissues: Focus on FRET-based cGMP indicators.

20. Calpain inhibition improves erectile function in diabetic mice via upregulating endothelial nitric oxide synthase expression and reducing apoptosis.

21. Guanylate cyclase-activating protein 2 contributes to phototransduction and light adaptation in mouse cone photoreceptors.

22. Enzymatic synthesis of cyclic dinucleotide analogs by a promiscuous cyclic-AMP-GMP synthetase and analysis of cyclic dinucleotide responsive riboswitches.

23. The Discovery of ( S)-1-(6-(3-((4-(1-(Cyclopropanecarbonyl)piperidin-4-yl)-2-methylphenyl)amino)-2,3-dihydro-1 H-inden-4-yl)pyridin-2-yl)-5-methyl-1 H-pyrazole-4-carboxylic Acid, a Soluble Guanylate Cyclase Activator Specifically Designed for Topical Ocular Delivery as a Therapy for Glaucoma.

24. Role of Cyclic di-GMP in the Bacterial Virulence and Evasion of the Plant Immunity.

25. Meeting report of the 8 th International Conference on cGMP "cGMP: generators, effectors, and therapeutic implications" at Bamberg, Germany, from June 23 to 25, 2017.

26. Cellulose production is coupled to sensing of the pyrimidine biosynthetic pathway via c-di-GMP production by the DgcQ protein of Escherichia coli.

27. Poly (I:C) impairs NO donor-induced relaxation by overexposure to NO via the NF-kappa B/iNOS pathway in rat superior mesenteric arteries.

28. Adaptation to copper stress influences biofilm formation in Alteromonas macleodii.

29. An evolutionary optimization of a rhodopsin-based phototrophic metabolism in Escherichia coli.

30. Cyclic di-GMP: second messenger extraordinaire.

31. Adipocytokine, progranulin, augments acetylcholine-induced nitric oxide-mediated relaxation through the increases of cGMP production in rat isolated mesenteric artery.

32. Superoxide generation from nNOS splice variants and its potential involvement in redox signal regulation.

33. GSNOR Deficiency Enhances In Situ Skeletal Muscle Strength, Fatigue Resistance, and RyR1 S-Nitrosylation Without Impacting Mitochondrial Content and Activity.

34. Enzymatic Production of c-di-GMP Using a Thermophilic Diguanylate Cyclase.

35. Analysis of c-di-GMP Levels Synthesized by a Photoreceptor Protein in Response to Different Light Qualities Using an In Vitro Enzymatic Assay.

36. Spectrophotometric and Mass Spectroscopic Methods for the Quantification and Kinetic Evaluation of In Vitro c-di-GMP Synthesis.

37. Targeting c-di-GMP Signaling, Biofilm Formation, and Bacterial Motility with Small Molecules.

38. In Vitro Assessment of Guanylyl Cyclase Activity of Plant Receptor Kinases.

39. C-di-GMP Synthesis: Structural Aspects of Evolution, Catalysis and Regulation.

40. Cyclic diguanylate regulation of Bacillus cereus group biofilm formation.

41. Stimulators of the soluble guanylyl cyclase: promising functional insights from rare coding atherosclerosis-related GUCY1A3 variants.

42. Novel approaches to targeting PDE3 in cardiovascular disease.

43. The role of the globin-coupled sensor YddV in a mature E. coli biofilm population.

44. PhoB activation in non-limiting phosphate condition by the maintenance of high polyphosphate levels in the stationary phase inhibits biofilm formation in Escherichia coli.

45. In Vivo Synthesis of Cyclic-di-GMP Using a Recombinant Adenovirus Preferentially Improves Adaptive Immune Responses against Extracellular Antigens.

46. Rapid radiation in bacteria leads to a division of labour.

47. New Pharmacological Strategies to Increase cGMP.

48. Dexamethasone-dependent modulation of cyclic GMP synthesis in podocytes.

49. How rods respond to single photons: Key adaptations of a G-protein cascade that enable vision at the physical limit of perception.

50. C-type natriuretic peptide signalling drives homeostatic effects in human chondrocytes.

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