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3. Pembrolizumab or placebo with chemoradiotherapy followed by pembrolizumab or placebo for newly diagnosed, high-risk, locally advanced cervical cancer (ENGOT-cx11/GOG-3047/KEYNOTE-A18): overall survival results from a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Lorusso, Domenica, Xiang, Yang, Hasegawa, Kosei, Scambia, Giovanni, Leiva, Manuel, Ramos-Elias, Pier, Acevedo, Alejandro, Cvek, Jakub, Randall, Leslie, Pereira de Santana Gomes, Andrea Juliana, Contreras Mejía, Fernando, Helpman, Limor, Akıllı, Hüseyin, Lee, Jung-Yun, Saevets, Valeriya, Zagouri, Flora, Gilbert, Lucy, Sehouli, Jalid, Tharavichitkul, Ekkasit, Lindemann, Kristina, Colombo, Nicoletta, Chang, Chih-Long, Bednarikova, Marketa, Zhu, Hong, Oaknin, Ana, Christiaens, Melissa, Petru, Edgar, Usami, Tomoka, Liu, Peng, Yamada, Karin, Toker, Sarper, Keefe, Stephen M, Pignata, Sandro, and Duska, Linda R

Published
2024
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5. Pembrolizumab plus concurrent chemoradiotherapy versus placebo plus concurrent chemoradiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck (KEYNOTE-412): a randomised, double-blind, phase 3 trial

Author

Rischin, Danny, Hughes, Brett GM, Gao, Bo, McGrath, Margaret, Greil, Richard, Thurnher, Dietmar, Fuereder, Thorsten, Burian, Martin, Rottey, Sylvie, Machiels, Jean-Pascal, Clement, Paul M, Henry, Stéphanie, Deheneffe, Stéphanie, Vasconcelos Alves, Gustavo, Lima, Iane Pinto Figueiredo, Mourão Dias, Josiane, De Marchi, Pedro Rafael Martins, Mak, Milena Perez, Pereira de Santana Gomes, Andrea Juliana, Oliveira de Castro Junior, Dalvaro, Motta, Tatiane Cardoso, Agostinho Padoan, Monica Luciana, Victorina, Ana Paula, de Azevedo, Sergio Jobim, Siu, Lillian L, Brule, Stephanie, Hilton, John, Wang, Chang Shu, Bouganim, Nathaniel, Webster, Marc, Walker, John, Chua, Neil, Zambrano, Angela Regina, Quiroga Echeverri, Alicia, Niño Gomez, Oscar Mauricio, Ortiz, Carlos Alberto, Rojas, Luis, Cardona Zorilla, Andrés, Urrego Meléndez, Olga Marcela, Holečková, Petra Beran, Melichar, Bohuslav, Cvek, Jakub, Prausová, Jana, Vošmik, Milan, Delord, Jean-Pierre, Zasadny, Xavier, Geoffrois, Lionnel, Tao, Yungan, Pointreau, Yoann, Fietkau, Rainer, Haderlein, Marlen, Mueller, Andreas H, Schroeder, Ursula, Wollenberg, Barbara, Laban, Simon, Ivanyi, Philipp, Gruenwald, Viktor, Schafhausen, Philippe, Gutfeld, Orit, Gluck, Iris, Popovtzer, Aron, Meirovitz, Amichay, Billan, Salem, Brenner, Baruch, Limon, Dror, Licitra, Lisa, Perri, Francesco, Caponigro, Francesco, Violati, Martina, Ferrari, Daris, Nole, Franco, Bertolini, Federica, Livi, Lorenzo, Ghi, Maria Grazia, Imarisio, Ilaria, Tahara, Makoto, Homma, Akihiro, Ueda, Tsutomu, Asada, Yukinori, Yamazaki, Tomoko, Matsumoto, Koji, Fujii, Takashi, Ikeda, Sadakatsu, Takahashi, Shunji, Kinoshita, Takashi, Sasaki, Keita, Tsuji, Akihito, Ahn, Myung-Ju, Cho, Byoung Chul, Lee, Keun-Wook, Lee, Ki Hyeong, Choi, Moon Ki, Yun, Hwan Jung, Hendriks, Mathijs P, Oosting, Sjoukje F, Buter, Jan, Van Meerten, Esther, Graham, Jonathan, Kawecki, Andrzej, Debicka, Izabella, Maciejczyk, Adam, Pysz, Maciej, Filarska, Dorota, Hetnał, Marcin, Koralewski, Piotr, Wygoda, Andrzej, Składowski, Krzysztof, Talerczyk, Małgorzata, Berrocal Jaime, Alfonso, Pérez Segura, Pedro, Braña García, Irene, Basté Rotllan, Neus, Mesía Nin, Ricard, Taberna Sanz, Miren, Iglesias Docampo, Lara, Soria Rivas, Ainara, Rueda Domínguez, Antonio, Trigo Pérez, José Manuel, Hong, Ruey-Long, Li, Shau-Hsuan, Wang, Hung-Ming, Yen, Chia-Jui, Yang, Muh-Hwa, Chang, Yi-Fang, Liu, Yi-Chun, Lin, Jin-Ching, Ekenel, Meltem, Harputluoğlu, Hakan, Aksoy, Sercan, Özyilkan, Özgür, Bılıcı, Ahmet, Şendur, Mehmet Alı Nahıt, Arslan, Cagatay, Harrington, Kevin, Ramkumar, Shanmugasundaram, Gujral, Dorothy, Stewart, Simon, Powell, Melanie, Sibtain, Amen, Roques, Tom, Yip, Kent, Mirza, Arafat, Sivaramalingam, Muthiah, Belman, Neil D, Agarwala, Sanjiv, Anderson, Ian, Patel, Arpan, Maggiore, Ronald, Baumgart, Megan, Burtness, Barbara, Fidler, Mary Jo, Kaur, Varinder, Gaughan, Elizabeth, Worden, Francis, Rodriguez, Cristina P, Sukari, Ammar, Wong, Deborah, Yom, Sue, Walsh, William V, Fiorillo, Joseph A, Yorio, Jeffrey T, Obara, Grzegorz S, Alves, Gustavo, Hughes, Brett G M, Mesía, Ricard, Taberna, Miren, Waldron, John N, Simon, Christian, Grégoire, Vincent, Harrington, Kevin J, Swaby, Ramona F, Zhang, Yayan, Gumuscu, Burak, and Bidadi, Behzad

Published
2024
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7. A Framework for Assessing the Effect of Cardiac and Respiratory Motion for Stereotactic Arrhythmia Radioablation Using a Digital Phantom With a 17-Segment Model: A STOPSTORM.eu Consortium Study

Author

Stevens, Raoul R.F., Hazelaar, Colien, Bogowicz, Marta, ter Bekke, Rachel M.A., Volders, Paul G.A., Verhoeven, Karolien, de Ruysscher, Dirk, Verhoeff, Joost J.C., Fast, Martin F., Mandija, Stefano, Cvek, Jakub, Knybel, Lukas, Dvorak, Pavel, Blanck, Oliver, and van Elmpt, Wouter

Published
2024
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9. Refining critical structure contouring in STereotactic Arrhythmia Radioablation (STAR): Benchmark results and consensus guidelines from the STOPSTORM.eu consortium

Author

Balgobind, Brian V., Visser, Jorrit, Grehn, Melanie, Marquard Knap, Marianne, de Ruysscher, Dirk, Levis, Mario, Alcantara, Pino, Boda-Heggemann, Judit, Both, Marcus, Cozzi, Salvatore, Cvek, Jakub, Dieleman, Edith M.T., Elicin, Olgun, Giaj-Levra, Niccolò, Jumeau, Raphaël, Krug, David, Algara López, Manuel, Mayinger, Michael, Mehrhof, Felix, Miszczyk, Marcin, Pérez-Calatayud, Maria José, van der Pol, Luuk H.G., van der Toorn, Peter-Paul, Vitolo, Viviana, Postema, Pieter G., Pruvot, Etienne, Verhoeff, Joost C., and Blanck, Oliver

Published
2023
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10. Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for HER2-negative advanced gastric cancer (KEYNOTE-859): a multicentre, randomised, double-blind, phase 3 trial

Author

Mendez, Guillermo, O'Connor, Juan Manuel, Yanzi Castilla, Alvaro, Cundom, Juan, Kaen, Diego, Wong, Rachel, Ng, Weng, Aghmesheh, Morteza, Peressoni, Mauricio, Andrade, Carlos, Franke, Fabio, Alves, Gustavo, Cruz, Felipe Jose, Vianna, Karina, Monteiro, Maria Marcela, Raphael, Michael, Berry, Scott, Jang, Raymond, Tan, Ann, Asselah, Jamil, Yanez Weber, Patricio, Mahave, Mauricio, Sanchez, Cesar, Salman, Pamela, Bai, Yuxian, Li, Jin, Zhang, Xiaochun, Liu, Tianshu, Lin, Xiaoyan, Qin, Shukui, Yang, Jianwei, Luo, Suxia, Li, Wei, Ying, Jieer, Chen, Xi, Zeng, Shan, Qu, Yanli, Yang, Lin, Zhao, Lin, Chen, Ping, Pan, Hongming, Li, Enxiao, Ye, Feng, Lu, Jianwei, Liang, Xinjun, Zhao, Qun, Yin, Xianli, Li, Junhe, Ling, Yang, Lv, Guoqing, Li, Shouguo, Guerrero, Alvaro, Rubiano, Juan, Gonzalez Fernandez, Manuel, Manneh Kopp, Ray, Guzman Ramirez, Adrian, Corrales, Luis, Gonzalez Herrera, Ileana, Melichar, Bohuslav, Buchler, Tomas, Svoboda, Tomas, Obermannova, Radka, Vrana, David, Cvek, Jakub, Pfeiffer, Per, Baeksgaard, Lene, Yilmaz, Mette, Boige, Valerie, Lopez-Trabada, Daniel, Borg, Christophe, Pannier, Diane, Hiret, Sandrine, Di Fiore, Frederic, Metges, Jean-Philippe, Arnold, Dirk, Martens, Uwe, Lordick, Florian, Stein, Alexander, Castro, Hugo, Lopez, Karla, Ramirez, Julio, Aguilar, Mynor, Chivalan, Marco, Chan, Wendy, Cheng, Ashley, Yeo, Winnie, Arkosy, Peter, Csoszi, Tibor, Hitre, Erika, Horvath, Zsolt, Lowery, Maeve, McDermott, Ray, Morris, Patrick, Hubert, Ayala, Brenner, Baruch, Ben-Aharon, Irit, Shacham-Shmueli, Einat, Man, Sofia, Pelles Avraham, Sharon, Brenner, Ronen, Mishaeli, Moshe, Di Bartolomeo, Maria, Fazio, Nicola, Lonardi, Sara, Garufi, Carlo, Satoh, Taroh, Hara, Hiroki, Iwagami, Shiro, Yasui, Hisateru, Tsuda, Masahiro, Shimoyama, Tatsu, Shoji, Hirokazu, Sugimoto, Naotoshi, Shibata, Nobuhiro, Yamaguchi, Kensei, Amagai, Kenji, Choda, Yasuhiro, Esaki, Taito, Yabusaki, Hiroshi, Oshima, Takashi, Tsuji, Akihito, Kawakami, Hisato, Kawazoe, Akihito, Ishido, Kenji, Kadowaki, Shigenori, Martinez Rodriguez, Jorge, Herrera Martinez, Marytere, Huitzil Melendez, Fidel, Ramirez Godinez, Francisco, Balancan, Paola, Damianovich, Dragan, Castro Oliden, Victor, Grados, Julio, Torres, Cesar, Wyrwicz, Lucjan, Wysocki, Piotr, Hajac, Lukasz, Zolnierek, Jakub, Karaszewska, Boguslawa, Rha, Sun Young, Lee, Jeeyun, Ryu, Min-Hee, Oh, Do-Youn, Orlova, Rashida, Tjulandin, Sergey, Fadeeva, Natalia, Makarycheva, Yulia, Nosov, Dmitry, Smagina, Maria, Chan, Sze, Jacobs, Conrad, Kraus, Peter, Landers, Gregory, Robertson, Barbara, Ruff, Paul, Schoeman, Elizabeth, Maurel, Jean-Marc, Diez Garcia, Marc, Jimenez Fonseca, Paula, Gallego Plazas, Javier, Rivera Herrero, Fernando, Miranda Poma, Jesus, Layos Romero, Laura, Fritsch, Ralph, Bastian, Sara, Winterhalder, Ralph, Dosso, Sara De, Kossler, Thibaud, Yeh, Kun-Huei, Yen, Chia-Jui, Chen, Yen-Yang, Lin, Johnson, Bilici, Mehmet, Ozguroglu, Mustafa, Cil, Timucin, Oksuzoglu, Berna, Harputluoglu, Hakan, Karaoglu, Aziz, Hacibekiroglu, Ilhan, Erdogan, Bulent, Yalcin, Suayib, Adamchuk, Hryhoriy, Bondarenko, Igor, Kolesnik, Oleksii, Ostapenko, Yuriy, Kryzhanivska, Anna, Leshchenko, Lurii, Ilin, Ievgen, Shparyk, Yaroslav, Trukhin, Dmytro, Voitko, Nataliia, Roy, Rajarshi, Young, Anna-Mary, Medley, Louise, Shiu, Kai-Keen, Celano, Paul, Overton, Lindsay, Raj, Moses, Dunne, Richard, Wainberg, Zev, Dayyani, Farshid, Larson, Timothy, Kochenderfer, Mark, Yañez, Patricio, Rivera, Fernando, Alves, Gustavo Vasconcelos, Garrido, Marcelo, Fernández, Manuel González, Lowery, Maeve A, Çil, Timuçin, Cruz, Felipe Melo, Wainberg, Zev A, Yin, Lina, Bordia, Sonal, Bhagia, Pooja, and Wyrwicz, Lucjan S

Published
2023
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15. Pembrolizumab plus concurrent chemoradiotherapy versus placebo plus concurrent chemoradiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck (KEYNOTE-412): a randomised, double-blind, phase 3 trial

Author

Machiels, Jean-Pascal, primary, Tao, Yungan, additional, Licitra, Lisa, additional, Burtness, Barbara, additional, Tahara, Makoto, additional, Rischin, Danny, additional, Alves, Gustavo, additional, Lima, Iane Pinto Figueiredo, additional, Hughes, Brett G M, additional, Pointreau, Yoann, additional, Aksoy, Sercan, additional, Laban, Simon, additional, Greil, Richard, additional, Burian, Martin, additional, Hetnał, Marcin, additional, Delord, Jean-Pierre, additional, Mesía, Ricard, additional, Taberna, Miren, additional, Waldron, John N, additional, Simon, Christian, additional, Grégoire, Vincent, additional, Harrington, Kevin J, additional, Swaby, Ramona F, additional, Zhang, Yayan, additional, Gumuscu, Burak, additional, Bidadi, Behzad, additional, Siu, Lillian L, additional, Hughes, Brett GM, additional, Gao, Bo, additional, McGrath, Margaret, additional, Thurnher, Dietmar, additional, Fuereder, Thorsten, additional, Rottey, Sylvie, additional, Machiels, Jean-Pascal, additional, Clement, Paul M, additional, Henry, Stéphanie, additional, Deheneffe, Stéphanie, additional, Vasconcelos Alves, Gustavo, additional, Mourão Dias, Josiane, additional, De Marchi, Pedro Rafael Martins, additional, Mak, Milena Perez, additional, Pereira de Santana Gomes, Andrea Juliana, additional, Oliveira de Castro Junior, Dalvaro, additional, Motta, Tatiane Cardoso, additional, Agostinho Padoan, Monica Luciana, additional, Victorina, Ana Paula, additional, de Azevedo, Sergio Jobim, additional, Brule, Stephanie, additional, Hilton, John, additional, Wang, Chang Shu, additional, Bouganim, Nathaniel, additional, Webster, Marc, additional, Walker, John, additional, Chua, Neil, additional, Zambrano, Angela Regina, additional, Quiroga Echeverri, Alicia, additional, Niño Gomez, Oscar Mauricio, additional, Ortiz, Carlos Alberto, additional, Rojas, Luis, additional, Cardona Zorilla, Andrés, additional, Urrego Meléndez, Olga Marcela, additional, Holečková, Petra Beran, additional, Melichar, Bohuslav, additional, Cvek, Jakub, additional, Prausová, Jana, additional, Vošmik, Milan, additional, Zasadny, Xavier, additional, Geoffrois, Lionnel, additional, Fietkau, Rainer, additional, Haderlein, Marlen, additional, Mueller, Andreas H, additional, Schroeder, Ursula, additional, Wollenberg, Barbara, additional, Ivanyi, Philipp, additional, Gruenwald, Viktor, additional, Schafhausen, Philippe, additional, Gutfeld, Orit, additional, Gluck, Iris, additional, Popovtzer, Aron, additional, Meirovitz, Amichay, additional, Billan, Salem, additional, Brenner, Baruch, additional, Limon, Dror, additional, Perri, Francesco, additional, Caponigro, Francesco, additional, Violati, Martina, additional, Ferrari, Daris, additional, Nole, Franco, additional, Bertolini, Federica, additional, Livi, Lorenzo, additional, Ghi, Maria Grazia, additional, Imarisio, Ilaria, additional, Homma, Akihiro, additional, Ueda, Tsutomu, additional, Asada, Yukinori, additional, Yamazaki, Tomoko, additional, Matsumoto, Koji, additional, Fujii, Takashi, additional, Ikeda, Sadakatsu, additional, Takahashi, Shunji, additional, Kinoshita, Takashi, additional, Sasaki, Keita, additional, Tsuji, Akihito, additional, Ahn, Myung-Ju, additional, Cho, Byoung Chul, additional, Lee, Keun-Wook, additional, Lee, Ki Hyeong, additional, Choi, Moon Ki, additional, Yun, Hwan Jung, additional, Hendriks, Mathijs P, additional, Oosting, Sjoukje F, additional, Buter, Jan, additional, Van Meerten, Esther, additional, Graham, Jonathan, additional, Kawecki, Andrzej, additional, Debicka, Izabella, additional, Maciejczyk, Adam, additional, Pysz, Maciej, additional, Filarska, Dorota, additional, Koralewski, Piotr, additional, Wygoda, Andrzej, additional, Składowski, Krzysztof, additional, Talerczyk, Małgorzata, additional, Berrocal Jaime, Alfonso, additional, Pérez Segura, Pedro, additional, Braña García, Irene, additional, Basté Rotllan, Neus, additional, Mesía Nin, Ricard, additional, Taberna Sanz, Miren, additional, Iglesias Docampo, Lara, additional, Soria Rivas, Ainara, additional, Rueda Domínguez, Antonio, additional, Trigo Pérez, José Manuel, additional, Hong, Ruey-Long, additional, Li, Shau-Hsuan, additional, Wang, Hung-Ming, additional, Yen, Chia-Jui, additional, Yang, Muh-Hwa, additional, Chang, Yi-Fang, additional, Liu, Yi-Chun, additional, Lin, Jin-Ching, additional, Ekenel, Meltem, additional, Harputluoğlu, Hakan, additional, Özyilkan, Özgür, additional, Bılıcı, Ahmet, additional, Şendur, Mehmet Alı Nahıt, additional, Arslan, Cagatay, additional, Harrington, Kevin, additional, Ramkumar, Shanmugasundaram, additional, Gujral, Dorothy, additional, Stewart, Simon, additional, Powell, Melanie, additional, Sibtain, Amen, additional, Roques, Tom, additional, Yip, Kent, additional, Mirza, Arafat, additional, Sivaramalingam, Muthiah, additional, Belman, Neil D, additional, Agarwala, Sanjiv, additional, Anderson, Ian, additional, Patel, Arpan, additional, Maggiore, Ronald, additional, Baumgart, Megan, additional, Fidler, Mary Jo, additional, Kaur, Varinder, additional, Gaughan, Elizabeth, additional, Worden, Francis, additional, Rodriguez, Cristina P, additional, Sukari, Ammar, additional, Wong, Deborah, additional, Yom, Sue, additional, Walsh, William V, additional, Fiorillo, Joseph A, additional, Yorio, Jeffrey T, additional, and Obara, Grzegorz S, additional

Published
2024
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16. A Framework for Assessing the Effect of Cardiac and Respiratory Motion for Stereotactic Arrhythmia Radioablation Using a Digital Phantom With a 17-Segment Model: A STOPSTORM.eu Consortium Study

Author

MS Radiotherapie, Brain, Cancer, Circulatory Health, Experimentele klinische fysica, Computational Imaging, Stevens, Raoul R F, Hazelaar, Colien, Bogowicz, Marta, Ter Bekke, Rachel M A, Volders, Paul G A, Verhoeven, Karolien, de Ruysscher, Dirk, Verhoeff, Joost J C, Fast, Martin F, Mandija, Stefano, Cvek, Jakub, Knybel, Lukas, Dvorak, Pavel, Blanck, Oliver, van Elmpt, Wouter, MS Radiotherapie, Brain, Cancer, Circulatory Health, Experimentele klinische fysica, Computational Imaging, Stevens, Raoul R F, Hazelaar, Colien, Bogowicz, Marta, Ter Bekke, Rachel M A, Volders, Paul G A, Verhoeven, Karolien, de Ruysscher, Dirk, Verhoeff, Joost J C, Fast, Martin F, Mandija, Stefano, Cvek, Jakub, Knybel, Lukas, Dvorak, Pavel, Blanck, Oliver, and van Elmpt, Wouter

Published
2024

17. Hypertrophic obstructive cardiomyopathy with recurrent ventricular tachycardias: from catheter ablation and stereotactic radiotherapy to heart transplant—a case report.

Author

Kautzner, Josef, Hašková, Jana, Cvek, Jakub, Adamíra, Marek, and Peichl, Petr

Subjects
CATHETER ablation, HYPERTROPHIC cardiomyopathy, STEREOTACTIC radiotherapy, HEART transplantation, VENTRICULAR arrhythmia, ARRHYTHMIA, ATRIAL flutter
Abstract

Background Management of hypertrophic obstructive cardiomyopathy (HOCM) is often challenging, depending on clinical manifestation. This case report illustrates the complex treatment of HOCM with associated recurrent ventricular arrhythmias. Case summary A 54-year-old female with HOCM diagnosed in 2012 underwent a failed attempt for alcohol septal ablation, implantation of an implantable cardioverter-defibrillator, and repeated radiofrequency ablations (including ablation of the septal bulge to reduce LV obstruction). For ventricular tachycardia (VT) recurrences, she had stereotactic arrhythmia radioablation with subsequent epicardial cryoablation from mini-thoracotomy, and endocardial ablation with pulsed field energy. The situation was finally solved by mechanical support and heart transplantation. Discussion A few important lessons can be learned from the case. First, radiofrequency ablation was used successfully to decrease left outflow tract obstruction. Second, stereotactic radiotherapy has been used after four previous endo/epicardial catheter ablations to decrease the recurrences of VT. Third, mini-thoracotomy was used after previous epicardial ablation with subsequent adhesions to modify the epicardial substrate with cryoenergy. Fourth, pulsed field ablation of atrial fibrillation resulted in an excellent therapeutic effect. Fifth, pulsed field ablation was also used to modify the substrate for VT, and was complicated by transient AV block with haemodynamic deterioration requiring mechanical support. Finally, a heart transplant was the ultimate solution in the management of recurrent VT. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Optimized target delineation procedure for the radiosurgery treatment of ventricular tachycardia: observer-independent accuracy.

Author

Hecko, Jan, Knybel, Lukas, Rybar, Marian, Penhaker, Marek, Jiravsky, Otakar, Neuwirth, Radek, Sramko, Marek, Haskova, Jana, Kautzner, Josef, and Cvek, Jakub

Abstract

Background: Part of the current stereotactic arrythmia radioablation (STAR) workflow is transfer of findings from the electroanatomic mapping (EAM) to computed tomography (CT). Here, we analyzed inter- and intraobserver variation in a modified EAM-CT registration using automatic registration algorithms designed to yield higher robustness. Materials and methods: This work is based on data of 10 patients who had previously undergone STAR. Two observers participated in this study: (1) an electrophysiologist technician (cardiology) with substatial experience in EAM-CT merge, and (2) a clinical engineer (radiotherapy) with minimum experience with EAM-CT merge. EAM-CT merge consists of 3 main steps: segmentation of left ventricle from CT (CT LV), registration of the CT LV and EAM, clinical target volume (CTV) delineation from EAM specific points. Mean Hausdorff distance (MHD), Dice Similarity Coefficient (DSC) and absolute difference in Center of Gravity (CoG) were used to assess intra/interobserver variability. Results: Intraobserver variability: The mean DSC and MHD for 3 CT LVs altogether was 0.92 ± 0.01 and 1.49 ± 0.23 mm. The mean DSC and MHD for 3 CTVs altogether was 0,82 ± 0,06 and 0,71 ± 0,22 mm. Interobserver variability: Segmented CT LVs showed great similarity (mean DSC of 0,91 ± 0,01, MHD of 1,86 ± 0,47 mm). The mean DSC comparing CTVs from both observers was 0,81 ± 0,11 and MHD was 0,87 ± 0,45 mm. Conclusions: The high interobserver similarity of segmented LVs and delineated CTVs confirmed the robustness of the proposed method. Even an inexperienced user can perform a precise EAM-CT merge following workflow instructions. [ABSTRACT FROM AUTHOR]

Published
2024
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22. High PD-L1 expression on immune cells along with increased density of tumor-infiltrating lymphocytes predicts a favorable survival outcome for patients with loco-regionally advanced head and neck cancer: early results from a prospective study.

Author

Blažek, Tomáš, Petráš, Marek, Hurník, Pavel, Matoušek, Petr, Knybel, Lukáš, Čermáková, Zuzana Zděblová, Štembírek, Jan, Cvek, Jakub, and Soumarová, Renata

Subjects
HEAD & neck cancer, TUMOR-infiltrating immune cells, PROGRAMMED death-ligand 1, OVERALL survival, LONGITUDINAL method, SQUAMOUS cell carcinoma
Abstract

Introduction: In the era of personalized medicine and treatment optimization, use of immune biomarkers holds promise for estimating the prognosis of patients with head and neck squamous cell carcinoma (HNSCC) undergoing definitive treatment. Methods: To evaluate the prognostic potential of immune biomarkers, we conducted a prospective monocentric cohort study with loco-regionally advanced HNSCC patients indicated for definit ive radiotherapy/radiochemotherapy at the Department of Oncology, Ostrava University Hospital, Czech Republic, between June 2020 and August 2023. We focused on the expression of programmed death ligand 1 (PD-L1) and tumor-infiltrating lymphocytes (TILs) relative to overall survival (OS) and specific survival rates. Associations between biomarkers and survival rates were assessed by crude and adjusted hazard ratios (cHR, aHR, respectively) obtained from Cox proportional hazards regression. Results: Among a total of 55 patients within a median follow-up of 19.7 months, there were 21 (38.2%) all-cause deaths and 15 (27.3%) cancer-related deaths. An overall survival (OS) rate of 61.8% and a disease-specific survival (DSS) rate of 72.7% were recorded. A significant association between survival rates and a =10% difference in PD-L1 expression on immune versus tumor cells (high PD-L1IC expression) was documented regardless of the type of analysis (univariate or multivariate). In addition, a stronger association was confirmed for OS and the composite biomarker high PD-L1IC expression along with either median-higher CD8+ TIL count or increased TIL density =30%, as indicated by an aHR of 0.08 (95% CI, 0.01 to 0.52) and 0.07 (95% CI, 0.01 to 0.46), respectively. Similar results were demonstrated for other specific survival rates. Discussion: The early outcomes of the present study suggest the utility of a strong prognostic factor involving a composite biomarker high PD-L1IC expression along with increased TIL density in HNSCC patients undergoing definitive radiotherapy and radiochemotherapy. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for HER2-negative advanced gastric cancer (KEYNOTE-859): a multicentre, randomised, double-blind, phase 3 trial

Author

Rha, Sun Young, primary, Oh, Do-Youn, additional, Yañez, Patricio, additional, Bai, Yuxian, additional, Ryu, Min-Hee, additional, Lee, Jeeyun, additional, Rivera, Fernando, additional, Alves, Gustavo Vasconcelos, additional, Garrido, Marcelo, additional, Shiu, Kai-Keen, additional, Fernández, Manuel González, additional, Li, Jin, additional, Lowery, Maeve A, additional, Çil, Timuçin, additional, Cruz, Felipe Melo, additional, Qin, Shukui, additional, Luo, Suxia, additional, Pan, Hongming, additional, Wainberg, Zev A, additional, Yin, Lina, additional, Bordia, Sonal, additional, Bhagia, Pooja, additional, Wyrwicz, Lucjan S, additional, Mendez, Guillermo, additional, O'Connor, Juan Manuel, additional, Yanzi Castilla, Alvaro, additional, Cundom, Juan, additional, Kaen, Diego, additional, Wong, Rachel, additional, Ng, Weng, additional, Aghmesheh, Morteza, additional, Peressoni, Mauricio, additional, Andrade, Carlos, additional, Franke, Fabio, additional, Alves, Gustavo, additional, Cruz, Felipe Jose, additional, Vianna, Karina, additional, Monteiro, Maria Marcela, additional, Raphael, Michael, additional, Berry, Scott, additional, Jang, Raymond, additional, Tan, Ann, additional, Asselah, Jamil, additional, Yanez Weber, Patricio, additional, Mahave, Mauricio, additional, Sanchez, Cesar, additional, Salman, Pamela, additional, Zhang, Xiaochun, additional, Liu, Tianshu, additional, Lin, Xiaoyan, additional, Yang, Jianwei, additional, Li, Wei, additional, Ying, Jieer, additional, Chen, Xi, additional, Zeng, Shan, additional, Qu, Yanli, additional, Yang, Lin, additional, Zhao, Lin, additional, Chen, Ping, additional, Li, Enxiao, additional, Ye, Feng, additional, Lu, Jianwei, additional, Liang, Xinjun, additional, Zhao, Qun, additional, Yin, Xianli, additional, Li, Junhe, additional, Ling, Yang, additional, Lv, Guoqing, additional, Li, Shouguo, additional, Guerrero, Alvaro, additional, Rubiano, Juan, additional, Gonzalez Fernandez, Manuel, additional, Manneh Kopp, Ray, additional, Guzman Ramirez, Adrian, additional, Corrales, Luis, additional, Gonzalez Herrera, Ileana, additional, Melichar, Bohuslav, additional, Buchler, Tomas, additional, Svoboda, Tomas, additional, Obermannova, Radka, additional, Vrana, David, additional, Cvek, Jakub, additional, Pfeiffer, Per, additional, Baeksgaard, Lene, additional, Yilmaz, Mette, additional, Boige, Valerie, additional, Lopez-Trabada, Daniel, additional, Borg, Christophe, additional, Pannier, Diane, additional, Hiret, Sandrine, additional, Di Fiore, Frederic, additional, Metges, Jean-Philippe, additional, Arnold, Dirk, additional, Martens, Uwe, additional, Lordick, Florian, additional, Stein, Alexander, additional, Castro, Hugo, additional, Lopez, Karla, additional, Ramirez, Julio, additional, Aguilar, Mynor, additional, Chivalan, Marco, additional, Chan, Wendy, additional, Cheng, Ashley, additional, Yeo, Winnie, additional, Arkosy, Peter, additional, Csoszi, Tibor, additional, Hitre, Erika, additional, Horvath, Zsolt, additional, Lowery, Maeve, additional, McDermott, Ray, additional, Morris, Patrick, additional, Hubert, Ayala, additional, Brenner, Baruch, additional, Ben-Aharon, Irit, additional, Shacham-Shmueli, Einat, additional, Man, Sofia, additional, Pelles Avraham, Sharon, additional, Brenner, Ronen, additional, Mishaeli, Moshe, additional, Di Bartolomeo, Maria, additional, Fazio, Nicola, additional, Lonardi, Sara, additional, Garufi, Carlo, additional, Satoh, Taroh, additional, Hara, Hiroki, additional, Iwagami, Shiro, additional, Yasui, Hisateru, additional, Tsuda, Masahiro, additional, Shimoyama, Tatsu, additional, Shoji, Hirokazu, additional, Sugimoto, Naotoshi, additional, Shibata, Nobuhiro, additional, Yamaguchi, Kensei, additional, Amagai, Kenji, additional, Choda, Yasuhiro, additional, Esaki, Taito, additional, Yabusaki, Hiroshi, additional, Oshima, Takashi, additional, Tsuji, Akihito, additional, Kawakami, Hisato, additional, Kawazoe, Akihito, additional, Ishido, Kenji, additional, Kadowaki, Shigenori, additional, Martinez Rodriguez, Jorge, additional, Herrera Martinez, Marytere, additional, Huitzil Melendez, Fidel, additional, Ramirez Godinez, Francisco, additional, Balancan, Paola, additional, Damianovich, Dragan, additional, Castro Oliden, Victor, additional, Grados, Julio, additional, Torres, Cesar, additional, Wyrwicz, Lucjan, additional, Wysocki, Piotr, additional, Hajac, Lukasz, additional, Zolnierek, Jakub, additional, Karaszewska, Boguslawa, additional, Rha, Sun Young, additional, Orlova, Rashida, additional, Tjulandin, Sergey, additional, Fadeeva, Natalia, additional, Makarycheva, Yulia, additional, Nosov, Dmitry, additional, Smagina, Maria, additional, Chan, Sze, additional, Jacobs, Conrad, additional, Kraus, Peter, additional, Landers, Gregory, additional, Robertson, Barbara, additional, Ruff, Paul, additional, Schoeman, Elizabeth, additional, Maurel, Jean-Marc, additional, Diez Garcia, Marc, additional, Jimenez Fonseca, Paula, additional, Gallego Plazas, Javier, additional, Rivera Herrero, Fernando, additional, Miranda Poma, Jesus, additional, Layos Romero, Laura, additional, Fritsch, Ralph, additional, Bastian, Sara, additional, Winterhalder, Ralph, additional, Dosso, Sara De, additional, Kossler, Thibaud, additional, Yeh, Kun-Huei, additional, Yen, Chia-Jui, additional, Chen, Yen-Yang, additional, Lin, Johnson, additional, Bilici, Mehmet, additional, Ozguroglu, Mustafa, additional, Cil, Timucin, additional, Oksuzoglu, Berna, additional, Harputluoglu, Hakan, additional, Karaoglu, Aziz, additional, Hacibekiroglu, Ilhan, additional, Erdogan, Bulent, additional, Yalcin, Suayib, additional, Adamchuk, Hryhoriy, additional, Bondarenko, Igor, additional, Kolesnik, Oleksii, additional, Ostapenko, Yuriy, additional, Kryzhanivska, Anna, additional, Leshchenko, Lurii, additional, Ilin, Ievgen, additional, Shparyk, Yaroslav, additional, Trukhin, Dmytro, additional, Voitko, Nataliia, additional, Roy, Rajarshi, additional, Young, Anna-Mary, additional, Medley, Louise, additional, Celano, Paul, additional, Overton, Lindsay, additional, Raj, Moses, additional, Dunne, Richard, additional, Wainberg, Zev, additional, Dayyani, Farshid, additional, Larson, Timothy, additional, and Kochenderfer, Mark, additional

Published
2023
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25. STereotactic Arrhythmia Radioablation (STAR): the Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary consortium (STOPSTORM.eu) and review of current patterns of STAR practice in Europe

Author

Grehn, Melanie, Mandija, Stefano, Miszczyk, Marcin, Krug, David, Tomasik, Bartłomiej, Stickney, Kristine E, Alcantara, Pino, Alongi, Filippo, Anselmino, Matteo, Aranda, Ricardo Salgado, Balgobind, Brian V, Boda-Heggemann, Judit, Boldt, Leif-Hendrik, Bottoni, Nicola, Cvek, Jakub, Elicin, Olgun, De Ferrari, Gaetano Maria, Hassink, Rutger J, Hazelaar, Colien, Hindricks, Gerhard, Hurkmans, Coen, Iotti, Cinzia, Jadczyk, Tomasz, Jiravsky, Otakar, Jumeau, Raphaël, Buus Kristiansen, Steen, Levis, Mario, López, Manuel Algara, Martí-Almor, Julio, Mehrhof, Felix, Møller, Ditte Sloth, Molon, Giulio, Ouss, Alexandre, Peichl, Petr, Plasek, Jiri, Postema, Pieter G, Quesada, Aurelio, Reichlin, Tobias Roman, Rordorf, Roberto, Rudic, Boris, Saguner, Ardan M, Ter Bekke, Rachel M A, Torrecilla, José López, Troost, Esther G C, Vitolo, Viviana, Andratschke, Nicolaus, Zeppenfeld, Katja, Blamek, Slawomir, Fast, Martin, de Panfilis, Ludovica, Blanck, Oliver, Pruvot, Etienne, and Verhoeff, Joost J C

Subjects
Cardiac arrhythmias, CATHETER ABLATION, Stereotactic body radiotherapy, Stereotactic arrhythmia radioablation, 610 Medicine & health, Ventricular tachycardia, GUIDELINES, STRUCTURAL HEART-DISEASE, DELINEATION, Physiology (medical), RADIATION-THERAPY, VENTRICULAR-TACHYCARDIA, EU Horizon 2020, BODY RADIOTHERAPY, Cardiology and Cardiovascular Medicine, Consortium, CONTOURING ATLAS
Abstract

The EU Horizon 2020 Framework-funded Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary (STOPSTORM) consortium has been established as a large research network for investigating STereotactic Arrhythmia Radioablation (STAR) for ventricular tachycardia (VT). The aim is to provide a pooled treatment database to evaluate patterns of practice and outcomes of STAR and finally to harmonize STAR within Europe. The consortium comprises 31 clinical and research institutions. The project is divided into nine work packages (WPs): (i) observational cohort; (ii) standardization and harmonization of target delineation; (iii) harmonized prospective cohort; (iv) quality assurance (QA); (v) analysis and evaluation; (vi, ix) ethics and regulations; and (vii, viii) project coordination and dissemination. To provide a review of current clinical STAR practice in Europe, a comprehensive questionnaire was performed at project start. The STOPSTORM Institutions’ experience in VT catheter ablation (83% ≥ 20 ann.) and stereotactic body radiotherapy (59% > 200 ann.) was adequate, and 84 STAR treatments were performed until project launch, while 8/22 centres already recruited VT patients in national clinical trials. The majority currently base their target definition on mapping during VT (96%) and/or pace mapping (75%), reduced voltage areas (63%), or late ventricular potentials (75%) during sinus rhythm. The majority currently apply a single-fraction dose of 25 Gy while planning techniques and dose prescription methods vary greatly. The current clinical STAR practice in the STOPSTORM consortium highlights potential areas of optimization and harmonization for substrate mapping, target delineation, motion management, dosimetry, and QA, which will be addressed in the various WPs.

Published
2023

28. A framework for assessing the impact of cardiac and respiratory motion for STereotactic Arrhythmia Radioablation (STAR) using a digital phantom with a 17-segment model - A STOPSTORM.eu consortium study

Author

Stevens, Raoul R.F., primary, Hazelaar, Colien, additional, Bogowicz, Marta, additional, ter Bekke, Rachel M.A., additional, Volders, Paul G.A., additional, Verhoeven, Karolien, additional, de Ruysscher, Dirk, additional, Verhoeff, Joost J.C., additional, Fast, Martin F., additional, Mandija, Stefano, additional, Cvek, Jakub, additional, Knybel, Lukas, additional, Dvorak, Pavel, additional, Blanck, Oliver, additional, and van Elmpt, Wouter, additional

Published
2023
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32. https://www.prolekare.cz/en/journals/transfusion-and-haematology-today/2023-1-15/recommendations-for-thrombotic-risk-stratification-and-targeted-thromboprophylaxis-in-women-during-assisted-reproduction-133823

Author

Tesařová, Petra, primary, Karetová, Debora, additional, Hirmerová, Jana, additional, Malý, Radovan, additional, Vokurka, Samuel, additional, Kvasnička, Tomáš, additional, Kessler, Petr, additional, Ďulíček, Petr, additional, Gumulec, Jaromír, additional, Maňásek, Viktor, additional, Cvek, Jakub, additional, Prausová, Jana, additional, Melichar, Bohuslav, additional, Kopecký, Jindřich, additional, Kleinová, Jana, additional, Aulický, Petr, additional, Blatný, Jan, additional, and Penka, Miroslav, additional

Published
2023
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33. Refining critical structure contouring in STereotactic Arrhythmia Radioablation (STAR): Benchmark results and consensus guidelines from the STOPSTORM.eu consortium

Author

Experimentele klinische fysica, MS Radiotherapie, Brain, Cancer, Circulatory Health, Balgobind, Brian V, Visser, Jorrit, Grehn, Melanie, Marquard Knap, Marianne, de Ruysscher, Dirk, Levis, Mario, Alcantara, Pino, Boda-Heggemann, Judit, Both, Marcus, Cozzi, Salvatore, Cvek, Jakub, Dieleman, Edith M T, Elicin, Olgun, Giaj-Levra, Niccolò, Jumeau, Raphaël, Krug, David, Algara López, Manuel, Mayinger, Michael, Mehrhof, Felix, Miszczyk, Marcin, Pérez-Calatayud, Maria José, van der Pol, Luuk H G, van der Toorn, Peter-Paul, Vitolo, Viviana, Postema, Pieter G, Pruvot, Etienne, Verhoeff, Joost C, Blanck, Oliver, Experimentele klinische fysica, MS Radiotherapie, Brain, Cancer, Circulatory Health, Balgobind, Brian V, Visser, Jorrit, Grehn, Melanie, Marquard Knap, Marianne, de Ruysscher, Dirk, Levis, Mario, Alcantara, Pino, Boda-Heggemann, Judit, Both, Marcus, Cozzi, Salvatore, Cvek, Jakub, Dieleman, Edith M T, Elicin, Olgun, Giaj-Levra, Niccolò, Jumeau, Raphaël, Krug, David, Algara López, Manuel, Mayinger, Michael, Mehrhof, Felix, Miszczyk, Marcin, Pérez-Calatayud, Maria José, van der Pol, Luuk H G, van der Toorn, Peter-Paul, Vitolo, Viviana, Postema, Pieter G, Pruvot, Etienne, Verhoeff, Joost C, and Blanck, Oliver

Published
2023

34. Stereotactic Arrhythmia Radioablation (STAR): Assessment of cardiac and respiratory heart motion in ventricular tachycardia patients - A STOPSTORM.eu consortium review

Author

Experimentele klinische fysica, Cancer, Circulatory Health, Computational Imaging, MS Radiotherapie, Stevens, Raoul R F, Hazelaar, Colien, Fast, Martin F, Mandija, Stefano, Grehn, Melanie, Cvek, Jakub, Knybel, Lukas, Dvorak, Pavel, Pruvot, Etienne, Verhoeff, Joost, Blanck, Oliver, van Elmpt, Wouter, Experimentele klinische fysica, Cancer, Circulatory Health, Computational Imaging, MS Radiotherapie, Stevens, Raoul R F, Hazelaar, Colien, Fast, Martin F, Mandija, Stefano, Grehn, Melanie, Cvek, Jakub, Knybel, Lukas, Dvorak, Pavel, Pruvot, Etienne, Verhoeff, Joost, Blanck, Oliver, and van Elmpt, Wouter

Published
2023

35. STereotactic Arrhythmia Radioablation (STAR): the Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary consortium (STOPSTORM.eu) and review of current patterns of STAR practice in Europe

Author

Computational Imaging, Cancer, Funding & Support, Team Medisch, Circulatory Health, Experimentele klinische fysica, MS Radiotherapie, Grehn, Melanie, Mandija, Stefano, Miszczyk, Marcin, Krug, David, Tomasik, Bartłomiej, Stickney, Kristine E, Alcantara, Pino, Alongi, Filippo, Anselmino, Matteo, Aranda, Ricardo Salgado, Balgobind, Brian V, Boda-Heggemann, Judit, Boldt, Leif-Hendrik, Bottoni, Nicola, Cvek, Jakub, Elicin, Olgun, De Ferrari, Gaetano Maria, Hassink, Rutger J, Hazelaar, Colien, Hindricks, Gerhard, Hurkmans, Coen, Iotti, Cinzia, Jadczyk, Tomasz, Jiravsky, Otakar, Jumeau, Raphaël, Buus Kristiansen, Steen, Levis, Mario, López, Manuel Algara, Martí-Almor, Julio, Mehrhof, Felix, Møller, Ditte Sloth, Molon, Giulio, Ouss, Alexandre, Peichl, Petr, Plasek, Jiri, Postema, Pieter G, Quesada, Aurelio, Reichlin, Tobias, Rordorf, Roberto, Rudic, Boris, Saguner, Ardan M, Ter Bekke, Rachel M A, Torrecilla, José López, Troost, Esther G C, Vitolo, Viviana, Andratschke, Nicolaus, Zeppenfeld, Katja, Blamek, Slawomir, Fast, Martin, de Panfilis, Ludovica, Blanck, Oliver, Pruvot, Etienne, Verhoeff, Joost J C, Computational Imaging, Cancer, Funding & Support, Team Medisch, Circulatory Health, Experimentele klinische fysica, MS Radiotherapie, Grehn, Melanie, Mandija, Stefano, Miszczyk, Marcin, Krug, David, Tomasik, Bartłomiej, Stickney, Kristine E, Alcantara, Pino, Alongi, Filippo, Anselmino, Matteo, Aranda, Ricardo Salgado, Balgobind, Brian V, Boda-Heggemann, Judit, Boldt, Leif-Hendrik, Bottoni, Nicola, Cvek, Jakub, Elicin, Olgun, De Ferrari, Gaetano Maria, Hassink, Rutger J, Hazelaar, Colien, Hindricks, Gerhard, Hurkmans, Coen, Iotti, Cinzia, Jadczyk, Tomasz, Jiravsky, Otakar, Jumeau, Raphaël, Buus Kristiansen, Steen, Levis, Mario, López, Manuel Algara, Martí-Almor, Julio, Mehrhof, Felix, Møller, Ditte Sloth, Molon, Giulio, Ouss, Alexandre, Peichl, Petr, Plasek, Jiri, Postema, Pieter G, Quesada, Aurelio, Reichlin, Tobias, Rordorf, Roberto, Rudic, Boris, Saguner, Ardan M, Ter Bekke, Rachel M A, Torrecilla, José López, Troost, Esther G C, Vitolo, Viviana, Andratschke, Nicolaus, Zeppenfeld, Katja, Blamek, Slawomir, Fast, Martin, de Panfilis, Ludovica, Blanck, Oliver, Pruvot, Etienne, and Verhoeff, Joost J C

Published
2023

36. Refining Critical Structure Contouring in STereotactic Arrhythmia Radioablation (STAR): Benchmark Results and Consensus Guidelines from the STOPSTORM.eu Consortium

Author

Balgobind, Brian V, Visser, Jorrit, Grehn, Melanie, Marquard Knap, Marianne, de Ruysscher, Dirk, Levis, Mario, Alcantara, Pino, Boda-Heggemann, Judit, Both, Marcus, Cozzi, Salvatore, Cvek, Jakub, Dieleman, Edith M T, Elicin, Olgun, Giaj-Levra, Niccolò, Jumeau, Raphaël, Krug, David, Algara López, Manuel; https://orcid.org/0000-0002-0500-9202, Mayinger, Michael, Mehrhof, Felix, Miszczyk, Marcin, Pérez-Calatayud, Maria José, van der Pol, Luuk H G, van der Toorn, Peter-Paul, Vitolo, Viviana, Postema, Pieter G, Pruvot, Etienne, Verhoeff, Joost C, Blanck, Oliver, Balgobind, Brian V, Visser, Jorrit, Grehn, Melanie, Marquard Knap, Marianne, de Ruysscher, Dirk, Levis, Mario, Alcantara, Pino, Boda-Heggemann, Judit, Both, Marcus, Cozzi, Salvatore, Cvek, Jakub, Dieleman, Edith M T, Elicin, Olgun, Giaj-Levra, Niccolò, Jumeau, Raphaël, Krug, David, Algara López, Manuel; https://orcid.org/0000-0002-0500-9202, Mayinger, Michael, Mehrhof, Felix, Miszczyk, Marcin, Pérez-Calatayud, Maria José, van der Pol, Luuk H G, van der Toorn, Peter-Paul, Vitolo, Viviana, Postema, Pieter G, Pruvot, Etienne, Verhoeff, Joost C, and Blanck, Oliver

Abstract

BACKGROUND AND PURPOSE In patients with recurrent ventricular tachycardia (VT), STereotactic Arrhythmia Radioablation (STAR) shows promising results. The STOPSTORM consortium was established to investigate and harmonise STAR treatment in Europe. The primary goals of this benchmark study were to standardise contouring of organs at risk (OAR) for STAR, including detailed substructures of the heart, and accredit each participating centre. MATERIALS AND METHODS Centres within the STOPSTORM consortium were asked to delineate 31 OAR in three STAR cases. Delineation was reviewed by the consortium expert panel and after a dedicated workshop feedback and accreditation was provided to all participants. Further quantitative analysis was performed by calculating DICE similarity coefficients (DSC), median distance to agreement (MDA), and 95th percentile distance to agreement (HD95). RESULTS Twenty centres participated in this study. Based on DSC, MDA and HD95, the delineations of well-known OAR in radiotherapy were similar, such as lungs (median DSC=0.96, median MDA=0.1mm and median HD95=1.1mm) and aorta (median DSC=0.90, median MDA=0.1mm and median HD95=1.5mm). Some centres did not include the gastro-oesophageal junction, leading to differences in stomach and oesophagus delineations. For cardiac substructures, such as chambers (median DSC=0.83, median MDA=0.2mm and median HD95=0.5mm), valves (median DSC=0.16, median MDA=4.6mm and median HD95=16.0mm), coronary arteries (median DSC=0.4, median MDA=0.7mm and median HD95=8.3mm) and the sinoatrial and atrioventricular nodes (median DSC=0.29, median MDA=4.4mm and median HD95=11.4mm), deviations between centres occurred more frequently. After the dedicated workshop all centres were accredited and contouring consensus guidelines for STAR were established. CONCLUSION This STOPSTORM multi-centre critical structure contouring benchmark study showed high agreement for standard radiotherapy OAR. However, for cardiac substructures larger dis

Published
2023

37. STereotactic Arrhythmia Radioablation (STAR): the Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary consortium (STOPSTORM.eu) and review of current patterns of STAR practice in Europe

Author

Grehn, Melanie; https://orcid.org/0000-0002-6170-5122, Mandija, Stefano; https://orcid.org/0000-0002-4612-5509, Miszczyk, Marcin; https://orcid.org/0000-0002-4375-0827, Krug, David; https://orcid.org/0000-0001-8811-5416, Tomasik, Bartłomiej; https://orcid.org/0000-0001-5648-345X, Stickney, Kristine E, Alcantara, Pino; https://orcid.org/0000-0001-5744-9480, Alongi, Filippo, Anselmino, Matteo; https://orcid.org/0000-0002-6311-4270, Aranda, Ricardo Salgado; https://orcid.org/0000-0002-2627-8436, Balgobind, Brian V, Boda-Heggemann, Judit, Boldt, Leif-Hendrik, Bottoni, Nicola, Cvek, Jakub; https://orcid.org/0000-0003-1579-1792, Elicin, Olgun; https://orcid.org/0000-0002-6996-0646, De Ferrari, Gaetano Maria; https://orcid.org/0000-0003-4940-0876, Hassink, Rutger J; https://orcid.org/0000-0003-0237-7867, Hazelaar, Colien, Hindricks, Gerhard; https://orcid.org/0000-0002-0132-0773, Hurkmans, Coen; https://orcid.org/0000-0003-2268-0492, Iotti, Cinzia; https://orcid.org/0000-0001-9686-7298, Jadczyk, Tomasz; https://orcid.org/0000-0002-7955-9100, Jiravsky, Otakar; https://orcid.org/0000-0001-9334-5734, Jumeau, Raphaël; https://orcid.org/0000-0002-0098-8835, Kristiansen, Steen Buus, Levis, Mario; https://orcid.org/0000-0002-7668-3296, López, Manuel Algara; https://orcid.org/0000-0002-0500-9202, Martí-Almor, Julio; https://orcid.org/0000-0001-9927-1190, Mehrhof, Felix; https://orcid.org/0000-0003-0553-4290, et al, Grehn, Melanie; https://orcid.org/0000-0002-6170-5122, Mandija, Stefano; https://orcid.org/0000-0002-4612-5509, Miszczyk, Marcin; https://orcid.org/0000-0002-4375-0827, Krug, David; https://orcid.org/0000-0001-8811-5416, Tomasik, Bartłomiej; https://orcid.org/0000-0001-5648-345X, Stickney, Kristine E, Alcantara, Pino; https://orcid.org/0000-0001-5744-9480, Alongi, Filippo, Anselmino, Matteo; https://orcid.org/0000-0002-6311-4270, Aranda, Ricardo Salgado; https://orcid.org/0000-0002-2627-8436, Balgobind, Brian V, Boda-Heggemann, Judit, Boldt, Leif-Hendrik, Bottoni, Nicola, Cvek, Jakub; https://orcid.org/0000-0003-1579-1792, Elicin, Olgun; https://orcid.org/0000-0002-6996-0646, De Ferrari, Gaetano Maria; https://orcid.org/0000-0003-4940-0876, Hassink, Rutger J; https://orcid.org/0000-0003-0237-7867, Hazelaar, Colien, Hindricks, Gerhard; https://orcid.org/0000-0002-0132-0773, Hurkmans, Coen; https://orcid.org/0000-0003-2268-0492, Iotti, Cinzia; https://orcid.org/0000-0001-9686-7298, Jadczyk, Tomasz; https://orcid.org/0000-0002-7955-9100, Jiravsky, Otakar; https://orcid.org/0000-0001-9334-5734, Jumeau, Raphaël; https://orcid.org/0000-0002-0098-8835, Kristiansen, Steen Buus, Levis, Mario; https://orcid.org/0000-0002-7668-3296, López, Manuel Algara; https://orcid.org/0000-0002-0500-9202, Martí-Almor, Julio; https://orcid.org/0000-0001-9927-1190, Mehrhof, Felix; https://orcid.org/0000-0003-0553-4290, and et al

Abstract

The EU Horizon 2020 Framework-funded Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary (STOPSTORM) consortium has been established as a large research network for investigating STereotactic Arrhythmia Radioablation (STAR) for ventricular tachycardia (VT). The aim is to provide a pooled treatment database to evaluate patterns of practice and outcomes of STAR and finally to harmonize STAR within Europe. The consortium comprises 31 clinical and research institutions. The project is divided into nine work packages (WPs): (i) observational cohort; (ii) standardization and harmonization of target delineation; (iii) harmonized prospective cohort; (iv) quality assurance (QA); (v) analysis and evaluation; (vi, ix) ethics and regulations; and (vii, viii) project coordination and dissemination. To provide a review of current clinical STAR practice in Europe, a comprehensive questionnaire was performed at project start. The STOPSTORM Institutions' experience in VT catheter ablation (83% ≥ 20 ann.) and stereotactic body radiotherapy (59% > 200 ann.) was adequate, and 84 STAR treatments were performed until project launch, while 8/22 centres already recruited VT patients in national clinical trials. The majority currently base their target definition on mapping during VT (96%) and/or pace mapping (75%), reduced voltage areas (63%), or late ventricular potentials (75%) during sinus rhythm. The majority currently apply a single-fraction dose of 25 Gy while planning techniques and dose prescription methods vary greatly. The current clinical STAR practice in the STOPSTORM consortium highlights potential areas of optimization and harmonization for substrate mapping, target delineation, motion management, dosimetry, and QA, which will be addressed in the various WPs.

Published
2023

40. HPV and RAD51 as Prognostic Factors for Survival in Inoperable Oral and Oropharyngeal Cancer in Patients Unfit for Chemotherapy Treated with Hyperfractionated Radiotherapy

Author

Zděblová Čermáková, Zuzana, primary, Hurník, Pavel, additional, Konvalinka, David, additional, Štembírek, Jan, additional, Paračková, Tereza, additional, Resová, Kamila, additional, Cvek, Jakub, additional, Blažek, Tomáš, additional, Knybel, Lukáš, additional, Formánek, Martin, additional, Gachechiladze, Mariam, additional, Joerger, Markus, additional, Soltermann, Alex, additional, Škarda, Jozef, additional, Motyka, Oldřich, additional, and Janoutová, Jana, additional

Published
2023
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44. Oncology wounds – recommendations for care based on multidisciplinary cooperation

Author

Vokurka, Samuel, primary, Pokorná, Andrea, additional, Stryja, Jan, additional, Krupová, Lenka, additional, Mezera, Vojtěch, additional, Cvek, Jakub, additional, Holečková, Petra, additional, Ston, Robert, additional, Hašková, Libuše, additional, Audyová, Magda, additional, Pechačová, Zdeňka, additional, Šípová, Simona, additional, Jirsová, Kateřina, additional, and Veverková, Lenka, additional

Published
2022
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46. Péče o kůži u pacientů podstupujících radioterapii.

Author

Krupová, Lenka and Cvek, Jakub

Subjects
SKIN care, RADIODERMATITIS, PATIENT education, GENERAL practitioners, PRIMARY care
Abstract

Copyright of Dermatologie Pro Praxi is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023

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