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147 results on '"Cuttica, Ruben"'

1. Correction: S100 proteins as potential predictive biomarkers of abatacept response in polyarticular juvenile idiopathic arthritis

Author

Brunner, Hermine I, Schulert, Grant S, Sproles, Alyssa, Thornton, Sherry, Cornejo, Gabriel Vega, Antón, Jordi, Cuttica, Ruben, Henrickson, Michael, Foeldvari, Ivan, Kingsbury, Daniel J, Askelson, Margarita, Liu, Jinqi, Mukherjee, Sumanta, Wong, Robert L, Lovell, Daniel J, Martini, Alberto, Ruperto, Nicolino, and Grom, Alexei A

Published
2024
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2. S100 proteins as potential predictive biomarkers of abatacept response in polyarticular juvenile idiopathic arthritis

Author

Brunner, Hermine I, Schulert, Grant S, Sproles, Alyssa, Thornton, Sherry, Cornejo, Gabriel Vega, Antón, Jordi, Cuttica, Ruben, Henrickson, Michael, Foeldvari, Ivan, Kingsbury, Daniel J, Askelson, Margarita, Liu, Jinqi, Mukherjee, Sumanta, Wong, Robert L, Lovell, Daniel J, Martini, Alberto, Ruperto, Nicolino, and Grom, Alexei A

Published
2024
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3. Safety and efficacy of tofacitinib for the treatment of patients with juvenile idiopathic arthritis: preliminary results of an open-label, long-term extension study.

Author

Brunner, Hermine I., Akikusa, Jonathan D., Al-Abadi, Eslam, Bohnsack, John F., Boteanu, Alina Lucica, Chedeville, Gaelle, Cuttica, Ruben, De La Pena, Wendy, Jung, Lawrence, Kasapcopur, Ozgur, Kobusinska, Katarzyna, Schulert, Grant S., Neiva, Claudia, Rivas-Chacon, Rafael, Rizo Rodriguez, Juan Cruz, Vazquez-Del Mercado, Monica, Wagner-Weiner, Linda, Weiss, Jennifer E., Wouters, Carine, and Posner, Holly

Published
2024
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4. Development and Initial Validation of the Macrophage Activation Syndrome/Primary Hemophagocytic Lymphohistiocytosis Score, a Diagnostic Tool that Differentiates Primary Hemophagocytic Lymphohistiocytosis from Macrophage Activation Syndrome

Author

Abinun, Mario, Aggarwal, Amita, Akikusa, Jonathan, Al-Mayouf, Sulaiman, Alessio, Maria, Anton, Jordi, Apaz, Maria Teresa, Astigarraga, Itziar, Avcin, Tadej, Ayaz, Nuray Aktay, Barone, Patrizia, Bica, Bianca, Bolt, Isabel, Bovis, Francesca, Breda, Luciana, Chasnyk, Vyacheslav, Cimaz, Rolando, Corona, Fabrizia, Cron, Randy Q., Cuttica, Ruben, Davì, Sergio, Davidsone, Zane, De Cunto, Carmen, De Inocencio, Jaime, Demirkaya, Erkan, Eisenstein, Eli M., Enciso, Sandra, Espada, Graciela, Fischbach, Michel, Frosch, Michael, Gallizzi, Romina, Gamir, Maria Luz, Gao, Yi-Jin, Griffin, Thomas, Grom, Alexei, Hashad, Soad, Hennon, Teresa, Henter, Jan-Inge, Horne, AnnaCarin, Horneff, Gerd, Huasong, Zeng, Huber, Adam, Ilowite, Norman, Insalaco, Antonella, Ioseliani, Maka, Jeng, Michael, Kapović, Agneza Marija, Kasapcopur, Ozgur, Khubchandani, Raju, Kitoh, Toshiyuki, Koné-Paut, Isabelle, de Oliveira, Sheila Knupp Feitosa, Lattanzi, Bianca, Lehmberg, Kai, Lepore, Loredana, Li, Caifeng, Lipton, Jeffrey M., Magni-Manzoni, Silvia, Maritsi, Despoina, Martini, Alberto, McCurdy, Deborah, Merino, Rosa, Micalizzi, Concetta, Miettunen, Paivi, Minoia, Francesca, Mulaosmanovic, Velma, Nichols, Kim E., Nielsen, Susan, Ozen, Seza, Pal, Priyankar, Prahalad, Sampath, Ravelli, Angelo, Rigante, Donato, Rumba-Rozenfelde, Ingrida, Ruperto, Nicolino, Russo, Ricardo, Magalhães, Claudia Saad, Sanner, Helga, Sewairi, Wafaa Mohamed Saad, Shenoi, Susan, Artur Silva, Clovis, Stanevicha, Valda, Sterba, Gary, Stine, Kimo C., Susic, Gordana, Sztajnbok, Flavio, Takei, Syuji, Trauzeddel, Ralf, Tsitsami, Elena, Unsal, Erbil, Uziel, Yosef, Vougiouka, Olga, Wallace, Carol A., Weaver, Lehn, E. Weiss, Jennifer, Weitzman, Sheila, Wouters, Carine, Wulffraat, Nico, Zletni, Mabruka, Arico, Maurizio, Egeler, R. Maarten, Filipovich, Alexandra H., Gadner, Helmut, Imashuku, Shinsaku, Janka, Gritta, Ladisch, Stephan, McClain, Ken L., and Webb, David

Published
2017
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6. Prednisone versus prednisone plus ciclosporin versus prednisone plus methotrexate in new-onset juvenile dermatomyositis: a randomised trial

Author

Ruperto, Nicolino, Pistorio, Angela, Oliveira, Sheila, Zulian, Francesco, Cuttica, Ruben, Ravelli, Angelo, Fischbach, Michel, Magnusson, Bo, Sterba, Gary, Avcin, Tadej, Brochard, Karine, Corona, Fabrizia, Dressler, Frank, Gerloni, Valeria, Apaz, Maria T, Bracaglia, Claudia, Cespedes-Cruz, Adriana, Cimaz, Rolando, Couillault, Gerard, Joos, Rik, Quartier, Pierre, Russo, Ricardo, Tardieu, Marc, Wulffraat, Nico, Bica, Blanca, Dolezalova, Pavla, Ferriani, Virginia, Flato, Berit, Bernard-Medina, Ana G, Herlin, Troels, Trachana, Maria, Meini, Antonella, Allain-Launay, Emma, Pilkington, Clarissa, Vargova, Veronika, Wouters, Carine, Angioloni, Simona, and Martini, Alberto

Published
2016
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7. Intravenous dosing of tocilizumab in patients younger than two years of age with systemic juvenile idiopathic arthritis: results from an open-label phase 1 clinical trial

Author

Mallalieu, Navita L., Wimalasundera, Sunethra, Hsu, Joy C., Douglass, Wendy, Wells, Chris, Penades, Inmaculada Calvo, Cuttica, Ruben, Huppertz, Hans-Iko, Joos, Rik, Kimura, Yukiko, Milojevic, Diana, Rosenkranz, Margalit, Schikler, Kenneth, Constantin, Tamas, and Wouters, Carine

Published
2019
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8. The PRINTO evidence-based proposal for glucocorticoids tapering/discontinuation in new onset juvenile dermatomyositis patients

Author

Giancane, Gabriella, Lavarello, Claudio, Pistorio, Angela, Oliveira, Sheila K., Zulian, Francesco, Cuttica, Ruben, Fischbach, Michel, Magnusson, Bo, Pastore, Serena, Marini, Roberto, Martino, Silvana, Pagnier, Anne, Soler, Christine, Staņēvicha, Valda, Ten Cate, Rebecca, Uziel, Yosef, Vojinovic, Jelena, Fueri, Elena, Ravelli, Angelo, Martini, Alberto, Ruperto, Nicolino, and for the Paediatric Rheumatology International Trials Organisation (PRINTO)

Published
2019
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9. 2016 Classification Criteria for Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: A European League Against Rheumatism/American College of Rheumatology/Paediatric Rheumatology International Trials Organisation Collaborative Initiative

Author

Ravelli, Angelo, Minoia, Francesca, Davì, Sergio, Horne, AnnaCarin, Bovis, Francesca, Pistorio, Angela, Aricò, Maurizio, Avcin, Tadej, Behrens, Edward M., De Benedetti, Fabrizio, Filipovic, Lisa, Grom, Alexei A., Henter, Jan-Inge, Ilowite, Norman T., Jordan, Michael B., Khubchandani, Raju, Kitoh, Toshiyuki, Lehmberg, Kai, Lovell, Daniel J., Miettunen, Paivi, Nichols, Kim E., Ozen, Seza, Schmid, Jana Pachlopnik, Ramanan, Athimalaipet V., Russo, Ricardo, Schneider, Rayfel, Sterba, Gary, Uziel, Yosef, Wallace, Carol, Wouters, Carine, Wulffraat, Nico, Demirkaya, Erkan, Brunner, Hermine I., Martini, Alberto, Ruperto, Nicolino, Cron, Randy Q., Abinun, Mario, Aggarwal, Amita, Akikusa, Jonathan, Al-Mayouf, Sulaiman M., Alessio, Maria, Anton, Jordi, Apaz, Maria Teresa, Astigarraga, Itziar, Ayaz, Nuray A., Barone, Patrizia, Bica, Blanca, Bolt, Isabel, Breda, Luciana, Chasnyk, Vyacheslav, Cimaz, Rolando, Corona, Fabrizia, Cuttica, Ruben, DʼAngelo, Gianfranco, Davidsone, Zane, De Cunto, Carmen, De Inocencio, Jaime, Eisenstein, Eli, Enciso, Sandra, Espada, Graciela, Fischbach, Michel, Frosch, Michael, Gallizzi, Romina, Gamir, Maria Luz, Gao, Yi-Jin, Griffin, Thomas, Hashad, Soad, Hennon, Teresa, Horneff, Gerd, Huasong, Zeng, Huber, Adam, Ilowite, Norman, Insalaco, Antonella, Ioseliani, Maka, Jelusic-Drazic, Marijia, Jeng, Michael, Kapovic, Agneza, Kasapcopur, Ozgur, Kone-Paut, Isabelle, de Oliveira, Sheila Knupp Feitosa, Lattanzi, Bianca, Lepore, Loredana, Li, Caifeng, Lipton, Jeffrey M., Magni-Manzoni, Silvia, Maritsi, Despoina, McCurdy, Deborah, Merino, Rosa, Mulaosmanovic, Velma, Nielsen, Susan, Pal, Priyankar, Prahalad, Sampath, Rigante, Donato, Rumba-Rozenfelde, Ingrida, Magalhaes, Claudia Saad, Sanner, Helga, Sawhney, Sujata, Sewairi, Wafaa M., Shakoory, Bita, Shenoi, Susan, Clovis, Artur Silva, Stanevicha, Valda, Stine, Kimo C., Susic, Gordana, Sztajnbok, Flavio, Takei, Syuji, Tezer, Hasan, Trauzeddel, Ralf, Tsitsami, Elena, Unsal, Erbil, Vougiouka, Olga, Weaver, Lehn K., Weiss, Jennifer, Weitzman, Sheila, and Zletni, Mabruka

Published
2016
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10. Rate and Clinical Presentation of Macrophage Activation Syndrome in Patients With Systemic Juvenile Idiopathic Arthritis Treated With Canakinumab

Author

Grom, Alexei A., Ilowite, Norman T., Pascual, Virginia, Brunner, Hermine I., Martini, Alberto, Lovell, Daniel, Ruperto, Nicolino, Leon, Karolynn, Lheritier, Karine, Abrams, Ken, Cuttica, Ruben, Emminger, Wolfgang, Goffin, Laurence, Joos, Rik, Lauwerys, Bernard, Wouters, Carine, Hilário, Maria Odete Esteves, de Oliveira, Sheila Knupp Feitosa, Len, Claudio, Radominski, Sebastiao, Sztajnbok, Flavio Roberto, Haddad, Elie, Hofer, Michael, Houghton, Kristin, Huber, Adam, Saurenmann, Traudel, Schneider, Rayfel, Tucker, Lori, Bader-Meunier, Brigitte, Desjonqueres, Marine, Fischbach, Michel, Kone-Paut, Isabelle, Marie, Isabelle, Mogenet, Agnes, Mouy, Richard, Quartier, Pierre, Berner, Reinhard, Foeldvari, Ivan, Foell, Dirk, Frosch, Michael, Haas, Johannes-Peter, Horneff, Gerd, Hufnagel, Markus, Kallinich, Tilmann, Kuemmerle-Deschner, Jasmin, Lehmann, Hartwig, Lutz, Thomas, Thon, Angelika, Trauzeddel, Ralf, Tzaribachev, Nikolay, Weibarth-Riedel, Elisabeth, Chrousos, Georgios, Trachana, Maria, Vougiouka, Olga, Constantin, Tamas, Barash, Judith, Berkun, Yackov, Brik, Riva, Harel, Liora, Nahum, Amit, Pade, Shay, Uziel, Yosef, Alessio, Maria, Cimaz, Rolando, Corona, Fabrizia, Gerloni, Valeria, Wulffraat, N. M., Ferrandiz, Manuel, Rutkowska-Sak, Lidia, Alekseeva, Ekaterina, Chasnyk, Vyacheslav, Nasonov, Evgeny, Stanislav, Marina, Anton, Jordi, Calvo, Inmaculada, Gamir, Mari Luz, Robledillos, Juan Carlos, Magnusson, Bo, Erguven, Muferet, Kasapcopur, Ozgur, Ozdogan, Huri, Ozen, Seza, Unsal, Erbil, Chieng, Alice, Foster, Helen, McCann, Liza, Ramanan, Athimalaip, Southwood, Taunton, Wilkinson, Nicholas, Woo, Patricia, Higgins, Gloria Christine, Kingsbury, Daniel, Lopez-Benitez, Jorge, Marzan, Katherine, Morris, Paula, Natter, Marc, and Schikler, Kenneth Noel

Published
2016
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11. Development and Initial Validation of the Macrophage Activation Syndrome/Primary Hemophagocytic Lymphohistiocytosis Score, a Diagnostic Tool that Differentiates Primary Hemophagocytic Lymphohistiocytosis from Macrophage Activation Syndrome

Author

Minoia, Francesca, Bovis, Francesca, Davì, Sergio, Insalaco, Antonella, Lehmberg, Kai, Shenoi, Susan, Weitzman, Sheila, Espada, Graciela, Gao, Yi-Jin, Anton, Jordi, Kitoh, Toshiyuki, Kasapcopur, Ozgur, Sanner, Helga, Merino, Rosa, Astigarraga, Itziar, Alessio, Maria, Jeng, Michael, Chasnyk, Vyacheslav, Nichols, Kim E., Huasong, Zeng, Li, Caifeng, Micalizzi, Concetta, Ruperto, Nicolino, Martini, Alberto, Cron, Randy Q., Ravelli, Angelo, Horne, AnnaCarin, Abinun, Mario, Aggarwal, Amita, Akikusa, Jonathan, Al-Mayouf, Sulaiman, Apaz, Maria Teresa, Avcin, Tadej, Ayaz, Nuray Aktay, Barone, Patrizia, Bica, Bianca, Bolt, Isabel, Breda, Luciana, Cimaz, Rolando, Corona, Fabrizia, Cuttica, Ruben, Davidsone, Zane, De Cunto, Carmen, De Inocencio, Jaime, Demirkaya, Erkan, Eisenstein, Eli M., Enciso, Sandra, Fischbach, Michel, Frosch, Michael, Gallizzi, Romina, Gamir, Maria Luz, Griffin, Thomas, Grom, Alexei, Hashad, Soad, Hennon, Teresa, Henter, Jan-Inge, Horne, AnnaCarin, Horneff, Gerd, Huber, Adam, Ilowite, Norman, Ioseliani, Maka, Kapović, Agneza Marija, Khubchandani, Raju, Koné-Paut, Isabelle, de Oliveira, Sheila Knupp Feitosa, Lattanzi, Bianca, Lepore, Loredana, Lipton, Jeffrey M., Magni-Manzoni, Silvia, Maritsi, Despoina, McCurdy, Deborah, Miettunen, Paivi, Mulaosmanovic, Velma, Nielsen, Susan, Ozen, Seza, Pal, Priyankar, Prahalad, Sampath, Rigante, Donato, Rumba-Rozenfelde, Ingrida, Ruperto, Nicolino, Russo, Ricardo, Magalhães, Claudia Saad, Sewairi, Wafaa Mohamed Saad, Silva, Clovis Artur, Stanevicha, Valda, Sterba, Gary, Stine, Kimo C., Susic, Gordana, Sztajnbok, Flavio, Takei, Syuji, Trauzeddel, Ralf, Tsitsami, Elena, Unsal, Erbil, Uziel, Yosef, Vougiouka, Olga, Wallace, Carol A., Weaver, Lehn, Weiss, Jennifer E., Wouters, Carine, Wulffraat, Nico, Zletni, Mabruka, Arico, Maurizio, Egeler, Maarten R., Filipovich, Alexandra H., Gadner, Helmut, Imashuku, Shinsaku, Janka, Gritta, Ladisch, Stephan, McClain, Ken L., and Webb, David

Published
2017
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12. American College of Rheumatology Provisional Criteria for Clinically Relevant Improvement in Children and Adolescents With Childhood-Onset Systemic Lupus Erythematosus

Author

Brunner, Hermine I, Holland, Michael J, Beresford, Michael W, Ardoin, Stacy P, Appenzeller, Simone, Silva, Clovis A, Flores, Francisco, Goilav, Beatrice, Aydin, Pinar Ozge Avar, Wenderfer, Scott E, Levy, Deborah M, Ravelli, Angelo, Khubchandani, Raju, Avcin, Tadej, Klein-Gitelman, Marisa S, Ruperto, Nicolino, Feldman, Brian M, Ying, Jun, Battagliotti, Cristina, Brusco, Maria Isabel, Cuttica, Ruben, De Cunto, Carmen, Espada, Graciela, Farfan, Maximiliano, Garay, Stella, Marcantoni, Maria, Marcela, Alvarez, Meiorin, Silvia, Rama, Maria Elena, Russo, Ricardo, Walsh, Carolina Torre, Zamparo, Celso, Adib, Navid, Akikusa, Jonathan, Boros, Christina, Lee, Senq J, Mckay, Damien, Piper, Susan, Joos, Rik, Bica, Blanca, Campos, Leonardo, Cavalcanti, Andre, do Prado, Rogerio, Donner-Maliki, Amanda, Fernandes, Taciana, Fonseca, Adriana, de Almeida, Rozana Gasparello, Guariento, Andressa, Gusman, Catherine, Fiorot, Fernanda Jusan, Oliveira, Sheila Knupp, Len, Claudio, Campos, Lucia M Arruda, Machado, Sandra, Marques, Luciana, de Carvalho, Luciana Martins, Moulin, Rodrigo, Pedroso, Soraya, Pileggi, Gecilmara, Romanelli, Paulo Roberto S, Saad-Magalhaes, Claudia, Sakamoto, Ana, Santos, Maria Carolina, Silva, Marco Felipe, Spelling, Paulo, Sztajnbok, Flavio, Terreri, Maria, Cabral, David, Chedeville, Gaelle, Ellsworth, Janet, Huber, Adam, Tucker, Lori, Houghton, Kristin, Borzutzky, Arturo, Ladino, Mabel, Norambuena, Ximena, Eraso, Ruth, Mosquera, Angela, Velasquez, Monica, Harjacek, Miroslav, Jelusic, Marija, Hermosilla, Cecilia Coto, Dolezalova, Pavla, Nielsen, Susan, Tineo, Carmen, Alegria, Mauricio, Dressler, Frank, Foell, Dirk, Ganser, Gerd, Hinze, Claas, Hufnagel, Markus, Lutz, Thomas, Trauzeddel, Ralf, Boiu, Sorina, Trachana, Maria, Tsitsami, Elena, Cifuentes, Mayra, Orban, Ilonka, Aggarwal, Amita, Sawhney, Sujata, Aviel, Yonatan Butbul, Cimaz, Rolando, Maggio, Maria Cristina, Rumba-Rozenfelde, Ingrid, Hashad, Soad, Lim, Sern Chin, Abud, Carlos, Burgos-Vargas, Ruben, Carreno-Manjarrez, Roberto, Enciso Pelaez, Sandra, Hernandez-Huirache, Hayde, Maldonado Velazquez, Rocio, Orozco, Javier, Rodriguez-Lozano, Ana Luisa, Rojas Pacheco, Omar Ernesto, Suarez Larios, Luz Maria, Vega, Gabriel, Ramirez Miramontes, Julia Veronica, Ruiz Lopez, Ivon Karina, Kamphuis, Sylvia, Schonenberg-Meinema, Dieneke, Concannon, Anthony, Yan, Jaqueline, Jaime, Martha Jarquin, Al Abrawi, Safiya, Vega, Cynthia, Lopez-Benitez, Jorge, Estrella, Amparo Ibanez, Miraval, Tatiana, Dans, Leonia, Kimseng, Karen Joy, Opoka-Winiarska, Violetta, Rutkowska-Sak, Lidia, Smolewska, Elzbieta, Conde, Marta, Guedes, Margarida, del Valle, Enid, Quintero-Del Rio, Ana, Ailioaie, Constantin, Sparchez, Mihaela, Alekseeva, Ekaterina, Keltsev, Vladimir, Al-Mayouf, Sulaiman, Asiri, Abdurhman, Suwairi, Wafaa, Susic, Gordana, Vijatov-Djuric, Gordana, Ang, Elizabeth, Arkachaisri, Thaschawee, Boteanu, Alina-Lucica, Lopez-Robledillo, Juan Carlos, San Ildefonso, Marta Medrano, Modesto, Consuelo, Calvo, Inmaculada, Sotoca-Fernandez, Jorge, Bolt, Isabel, Vilaiyuk, Soamarat, Al-Abadi, Eslam, Baildam, Eileen, Fotis, Lampros, Pain, Clare, Pilkington, Clarissa, Abulaban, Khalid, Barbar-Smiley, Fatima, Binstadt, Bryce, Bohnsack, John, Boneparth, Alexis, Brown, Diane, Chira, Peter, Cron, Randy, Dedeoglu, Fatma, Eberhard, Anne, Gedalia, Abraham, Grom, Alexei, Henrickson, Michael, Hom, Christine, Huggins, Jennifer, Jerath, Rita, Jones, Jordan, Jung, Lawrence, Kingsbury, Daniel, Lai, Jamie, Lovell, Daniel, Nanda, Kabita, Nocton, James, Olson, Judyann, O'Neil, Kathleen, Onel, Karen, Punaro, Lynn, Reiff, Andreas, Rouster-Stevens, Kelly, Ruth, Natasha, Schikler, Ken, Schmidt, Kara Murphy, Schulert, Grant, Shaham, Bracha, Singer, Nora, Smith, Judith, Sundel, Robert, Syverson, Grant, Vega-Fernandez, Patricia, Vehe, Richard, Wagner-Weiner, Linda, Cameto, Juan, Jurado, Rosario, Maldonado, Irama, Org, Paediat Rheumatology Int Trial, Collaborative, Pediat Rheumatology, AII - Inflammatory diseases, Graduate School, Paediatric Infectious Diseases / Rheumatology / Immunology, Brunner, Hermine I., Holland, Michael J., Beresford, Michael W., Ardoin, Stacy P., Appenzeller, Simone, Silva, Clovis A., Flores, Francisco, Goilav, Beatrice, Avar Aydin, Pinar Ozge, Wenderfer, Scott E., Levy, Deborah M., Ravelli, Angelo, Khubchandani, Raju, Avcin, Tadej, Klein-Gitelman, Marisa S., Ruperto, Nicolino, Feldman, Brian M., Ying, Jun, Battagliotti, Cristina, Brusco, Maria Isabel, Cuttica, Rubén, De Cunto, Carmen, Espada, Graciela, Farfan, Maximiliano, Garay, Stella, Marcantoni, Maria, Marcela, Alvarez, Meiorin, Silvia, Rama, Maria Elena, Russo, Ricardo, Torre Walsh, Carolina, Zamparo, Celso, Adib, Navid, Akikusa, Jonathan, Boros, Christina, Lee, Senq J., Mckay, Damien, Piper, Susan, Joos, Rik, Bica, Blanca, Campos, Leonardo, Cavalcanti, André, do Prado, Rogerio, Donner-Maliki, Amanda, Fernandes, Taciana, Fonseca, Adriana, Gasparello de Almeida, Rozana, Guariento, Andressa, Gusman, Catherine, Jusan Fiorot, Fernanda, Knupp Oliveira, Sheila, Len, Claudio, Arruda Campos, Lucia M., Machado, Sandra, Marques, Luciana, Martins de Carvalho, Luciana, Moulin, Rodrigo, Pedroso, Soraya, Pileggi, Gecilmara, Romanelli, Paulo Roberto S., Saad-Magalhaes, Claudia, Sakamoto, Ana, Santos, Maria Carolina, Silva, Marco Felipe, Spelling, Paulo, Sztajnbok, Slavio, Terreri, Maria, Cabral, David, Chédeville, Gaëlle, Ellsworth, Janet, Huber, Adam, Tucker, Lori, Houghton, Kristin, Borzutzky, Arturo, Ladino, Mabel, Norambuena, Ximena, Eraso, Ruth, Mosquera, Angela, Velasquez, Monica, Harjacek, Miroslav, Jelusic, Marija, Coto Hermosilla, Cecilia, Dolezalova, Pavla, Nielsen, Susan, Tineo, Carmen, Alegria, Mauricio, Dressler, Frank, Foell, Dirk, Ganser, Gerd, Hinze, Claa, Hufnagel, Marku, Lutz, Thoma, Trauzeddel, Ralf, Boiu, Sorina, Trachana, Maria, Tsitsami, Elena, Cifuentes, Mayra, Orbán, Ilonka, Aggarwal, Amita, Sawhney, Sujata, Butbul Aviel, Yonatan, Cimaz, Rolando, Maggio, Maria Cristina, Rumba-Rozenfelde, Ingrid, Hashad, Soad, Lim, Sern Chin, Abud, Carlo, Burgos-Vargas, Ruben, Carreño-Manjarrez, Roberto, Enciso Pelaez, Sandra, Hernandez-Huirache, Hayde, Maldonado Velázquez, Rocio, Orozco, Javier, Rodriguez-Lozano, Ana Luisa, Rojas Pacheco, Omar Ernesto, Suárez Larios, Luz Maria, Vega, Gabriel, Ramírez Miramontes, Julia Verónica, Ruíz Lopez, Ivon Karina, Kamphuis, Sylvia, Schonenberg-Meinema, Dieneke, Concannon, Anthony, Yan, Jaqueline, Jarquin Jaime, Martha, Al Abrawi, Safiya, Vega, Cynthia, Lopez-Benitez, Jorge, Ibáñez Estrella, Amparo, Miraval, Tatiana, Dans, Leonia, Kimseng, Karen Joy, Opoka-Winiarska, Violetta, Rutkowska-Sak, Lidia, Smolewska, Elzbieta, Conde, Marta, Guedes, Margarida, del Valle, Enid, Quintero-Del Rio, Ana, Ailioaie, Constantin, Sparchez, Mihaela, Alekseeva, Ekaterina, Keltsev, Vladimir, Al-Mayouf, Sulaiman, Asiri, Abdurhman, Suwairi, Wafaa, Susic, Gordana, Vijatov-Djuric, Gordana, Ang, Elizabeth, Arkachaisri, Thaschawee, Boteanu, Alina-Lucica, Lopez-Robledillo, Juan Carlo, Medrano San Ildefonso, Marta, Modesto, Consuelo, Calvo, Inmaculada, Sotoca-Fernandez, Jorge, Bolt, Isabel, Vilaiyuk, Soamarat, Al-Abadi, Eslam, Baildam, Eileen, Fotis, Lampro, Pain, Clare, Pilkington, Clarissa, Abulaban, Khalid, Barbar-Smiley, Fatima, Binstadt, Bryce, Bohnsack, John, Boneparth, Alexi, Brown, Diane, Chira, Peter, Cron, Randy, Dedeoglu, Fatma, Eberhard, Anne, Gedalia, Abraham, Grom, Alexei, Henrickson, Michael, Hom, Christine, Huggins, Jennifer, Jerath, Rita, Jones, Jordan, Jung, Lawrence, Kingsbury, Daniel, Lai, Jamie, Lovell, Daniel, Nanda, Kabita, Nocton, Jame, Olson, Judyann, O’Neil, Kathleen, Onel, Karen, Punaro, Lynn, Reiff, Andrea, Rouster-Stevens, Kelly, Ruth, Natasha, Schikler, Ken, Murphy Schmidt, Kara, Schulert, Grant, Shaham, Bracha, Singer, Nora, Smith, Judith, Sundel, Robert, Syverson, Grant, Vega-Fernandez, Patricia, Vehe, Richard, Wagner-Weiner, Linda, Cameto, Juan, Jurado, Rosario, Maldonado, Irama, and Pediatrics

Subjects
medicine.medical_specialty, Outcome Assessment, Health Care/methods, Adolescent, Delphi Technique, Antirheumatic Agents/therapeutic use, Severity of Illness Index, Child health, Article, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Internal medicine, Severity of illness, Outcome Assessment, Health Care, medicine, Pediatric nephrology, Humans, Lupus Erythematosus, Systemic, skin and connective tissue diseases, Child, 030203 arthritis & rheumatology, Systemic lupus erythematosus, Lupus erythematosus, Lupus Erythematosus, Receiver operating characteristic, business.industry, Consensus conference, childhood-onset systemic lupus erythematosus, Outcome Assessment, Health Care/methods, medicine.disease, Rheumatology,Systemic lupus erythematosus,autoimmune inflammatory disease, Antirheumatic Agents, Lupus Erythematosus, Systemic/drug therapy, Systemic/drug therapy, business, Algorithms
Abstract

OBJECTIVE: To develop a Childhood Lupus Improvement Index (CHILI) as a tool to measure response to therapy in childhood-onset systemic lupus erythematosus (cSLE), with a focus on clinically relevant improvement (CRIc SLE ). METHODS: Pediatric nephrology and rheumatology subspecialists (n = 213) experienced in cSLE management were invited to define CRIc SLE and rate a total of 433 unique patient profiles for the presence/absence of CRIc SLE . Patient profiles included the following cSLE core response variables (CRVs): global assessment of patient well-being (patient-global), physician assessment of cSLE activity (MD-global), disease activity index score (here, we used the Systemic Lupus Erythematosus Disease Activity Index), urine protein-to-creatinine ratio, and Child Health Questionnaire physical summary score. Percentage and absolute changes in these cSLE- CRVs (baseline versus follow-up) were considered in order to develop candidate algorithms and validate their performance (sensitivity, specificity, area under the receiver operating characteristic curve [AUC] ; range 0-1). RESULTS: During an international consensus conference, unanimous agreement on a definition of CRIc SLE was achieved ; cSLE experts (n = 13) concurred (100%) that the preferred CHILI algorithm considers absolute changes in the cSLE- CRVs. After transformation to a range of 0-100, a CHILI score of ≥54 had outstanding accuracy for identifying CRIc SLE (AUC 0.93, sensitivity 81.1%, and specificity 84.2%). CHILI scores also reflect minor, moderate, and major improvement for values exceeding 15, 68, and 92, respectively (all AUC ≥0.92, sensitivity ≥93.1%, and specificity ≥73.4%). CONCLUSION: The CHILI is a new, seemingly highly accurate index for measuring CRI in cSLE over time. This index is useful to categorize the degree of response to therapy in children and adolescents with cSLE.

Published
2019

13. Efficacy and safety of tocilizumab in patients with polyarticular-course juvenile idiopathic arthritis: results from a phase 3, randomised, double-blind withdrawal trial

Author

Brunner, Hermine I, Ruperto, Nicolino, Zuber, Zbigniew, Keane, Caroline, Harari, Olivier, Kenwright, Andrew, Lu, Peng, Cuttica, Ruben, Keltsev, Vladimir, Xavier, Ricardo M, Calvo, Inmaculada, Nikishina, Irina, Rubio-Pérez, Nadina, Alexeeva, Ekaterina, Chasnyk, Vyacheslav, Horneff, Gerd, Opoka-Winiarska, Violetta, Quartier, Pierre, Silva, Clovis A, Silverman, Earl, Spindler, Alberto, Baildam, Eileen, Gámir, M Luz, Martin, Alan, Rietschel, Christoph, Siri, Daniel, Smolewska, Elzbieta, Lovell, Daniel, Martini, Alberto, De Benedetti, Fabrizio, Espada, Graciela, Allen, Roger, Chaitow, Jeffrey, Joos, Rik, Wouters, Carine, Knupp, Sheila, Sztajnbok, Flavio, Cabral, David, Houghton, Kristin, Roth, Johannes, Schmeling, Heinrike, Job-Deslandre, Chantal, Jorgensen, Christian, Paut, Isabelle Kone, Minden, Kirsten, Weller-Heinemann, Frank, Gerloni, Valeria, Zulian, Francesco, Burgos-Vargas, Ruben, Salazar, Carolina Duarte, Solis-Vallejo, Eunice, Calvo, Armando, Chavez, José, Zavaler, Manuel Ferrandiz, Gruenpeter, Anna, Kobusinska, Katarzyna, Sarychev, Alexey, Zholobova, Elena, Ramanan, Athimalaipet, Woo, Patricia, Goodman, Steven, Gedalia, Abraham, Kimura, Yukiko, Onel, Karen, and Schikler, Kenneth

Published
2015
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14. Subcutaneous dosing regimens of tocilizumab in children with systemic or polyarticular juvenile idiopathic arthritis

Author

Ruperto, Nicolino, Brunner, Hermine, I, Ramanan, Athimalaipet, V, Horneff, Gerd, Cuttica, Ruben, Henrickson, Michael, Anton, Jordi, Lucica Boteanu, Alina, Calvo Penades, Inmaculada, Minden, Kirsten, Schmeling, Heinrike, Hufnagel, Markus, Weiss, Jennifer E., Pardeo, Manuela, Nanda, Kabita, Roth, Johannes, Rubio-Perez, Nadina, Hsu, Joy C., Wimalasundera, Sunethra, Wells, Chris, Bharucha, Kamal, Douglass, Wendy, Bao, Min, Mallalieu, Navita L., Martini, Alberto, Lovell, Daniel, De Benedetti, Fabrizio, Ruperto, Nicolino, Brunner, Hermine, I, Ramanan, Athimalaipet, V, Horneff, Gerd, Cuttica, Ruben, Henrickson, Michael, Anton, Jordi, Lucica Boteanu, Alina, Calvo Penades, Inmaculada, Minden, Kirsten, Schmeling, Heinrike, Hufnagel, Markus, Weiss, Jennifer E., Pardeo, Manuela, Nanda, Kabita, Roth, Johannes, Rubio-Perez, Nadina, Hsu, Joy C., Wimalasundera, Sunethra, Wells, Chris, Bharucha, Kamal, Douglass, Wendy, Bao, Min, Mallalieu, Navita L., Martini, Alberto, Lovell, Daniel, and De Benedetti, Fabrizio

Abstract

Objectives. To determine s.c. tocilizumab (s.c.-TCZ) dosing regimens for systemic JIA (sJIA) and polyarticular JIA (pJIA). Methods. In two 52-week phase 1 b trials, s.c.-TCZ (162 mg/dose) was administered to sJIA patients every week or every 2 weeks (every 10 days before interim analysis) and to pJIA patients every 2 weeks or every 3 weeks with body weight >= 30 kg or <30 kg, respectively. Primary end points were pharmacokinetics, pharmacodynamics and safety; efficacy was exploratory. Comparisons were made to data from phase 3 trials with i.v. tocilizumab (i.v.-TCZ) in sJIA and pJIA. Results. Study participants were 51 sJIA patients and 52 pJIA patients aged 1-17 years who received s.c.-TCZ. Steady-state minimum TCZ concentration (C-trough) >5th percentile of that achieved with i.v.-TCZ was achieved by 49 (96%) sJIA and 52 (100%) pJIA patients. In both populations, pharmacodynamic markers of disease were similar between body weight groups. Improvements in Juvenile Arthritis DAS-71 were comparable between s.c.-TCZ and i.v.-TCZ. By week 52, 53% of sJIA patients and 31% of pJIA patients achieved clinical remission on treatment. Safety was consistent with that of i.v.-TCZ except for injection site reactions, reported by 41.2% and 28.8% of sJIA and pJIA patients, respectively. Infections were reported in 78.4% and 69.2% of patients, respectively. Two sJIA patients died; both deaths were considered to be related to TCZ. Conclusion. s.c.-TCZ provides exposure and risk/benefit profiles similar to those of i.v.-TCZ. S.c. administration provides an alternative administration route that is more convenient for patients and caregivers and that has potential for in-home use.

Published
2021

15. Methotrexate withdrawal at 6 vs 12 months in juvenile idiopathic arthritis in remission

Author

Foell, Dirk, Wulfraat, Nico, Wedderburn, Lucy R., Wittkowski, Helmut, Frosch, Michael, Gerb, Joachim, Stanevicha, Valda, Mihaylova, Dimitrina, Ferriani, Virginia, Tsakalidou, Florence Kanakoudi, Foeldvari, Ivan, Cuttica, Ruben, Gonzalez, Benito, Ravelli, Angelo, Khubchandani, Raju, Oliviera, Sheila, Armbrust, Wineke, Garay, Stella, Vojinovic, Jelena, Norambuena, Ximena, Gamir, Maria Luz, Garcia-Consuegra, Julia, Lepore, Loredana, Susie, Gordana, Corona, Fabrizia, Dolezalova, Pavla, Pistorio, Angela, Martini, Alberto, Ruperto, Nicolino, and Roth, Johannes

Subjects
Methotrexate -- Usage, Methotrexate -- Health aspects, Juvenile arthritis -- Patient outcomes, Juvenile arthritis -- Drug therapy, Diseases -- Relapse, Diseases -- Evaluation
Abstract

The study aims to evaluate and compare the efficacy of methotrexate withdrawal at 6 months as against 12 months in juvenile idiopathic arthritis (JIA) in remission. The results indicate that in case of such patients, there was not much difference in reduction in relapse rate in either of the cases.

Published
2010

16. Performance of Current Guidelines for Diagnosis of Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis

Author

Davì, Sergio, Minoia, Francesca, Pistorio, Angela, Horne, AnnaCarin, Consolaro, Alessandro, Rosina, Silvia, Bovis, Francesca, Cimaz, Rolando, Gamir, Maria Luz, Ilowite, Norman T., Kone-Paut, Isabelle, Feitosa de Oliveira, Sheila Knupp, McCurdy, Deborah, Silva, Clovis Artur, Sztajnbok, Flavio, Tsitsami, Elena, Unsal, Erbil, Weiss, Jennifer E., Wulffraat, Nico, Abinun, Mario, Aggarwal, Amita, Apaz, Maria Teresa, Astigarraga, Itziar, Corona, Fabrizia, Cuttica, Ruben, DʼAngelo, Gianfranco, Eisenstein, Eli M., Hashad, Soad, Lepore, Loredana, Mulaosmanovic, Velma, Nielsen, Susan, Prahalad, Sampath, Rigante, Donato, Stanevicha, Valda, Sterba, Gary, Susic, Gordana, Takei, Syuji, Trauzeddel, Ralf, Zletni, Mabruka, Ruperto, Nicolino, Martini, Alberto, Cron, Randy Q., and Ravelli, Angelo

Published
2014
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17. Opportunistic infections in immunosuppressed patients with juvenile idiopathic arthritis: Analysis by the Pharmachild Safety Adjudication Committee

Author

Immuno/reuma patientenzorg, Child Health, Infectieziekten patientenzorg, Infection & Immunity, Cluster B, Immuno/reuma onderzoek 1 (Vastert), Immunologie/Reumatologie, Regenerative Medicine and Stem Cells, Onderzoek, Giancane, Gabriella, Swart, Joost F., Castagnola, Elio, Groll, Andreas H., Horneff, Gerd, Huppertz, Hans Iko, Lovell, Daniel J., Wolfs, Tom, Herlin, Troels, Dolezalova, Pavla, Sanner, Helga, Susic, Gordana, Sztajnbok, Flavio, Maritsi, Despoina, Constantin, Tamas, Vargova, Veronika, Sawhney, Sujata, Rygg, Marite, Oliveira, Sheila K., Cattalini, Marco, Bovis, Francesca, Bagnasco, Francesca, Pistorio, Angela, Martini, Alberto, Wulffraat, Nico, Ruperto, Nicolino, Cuttica, Ruben, Garay, Stella Maris, Brunner, Jurgen, Emminger, Wolfgang, Appenzeller, Simone, Len, Claudio, Saad Magalhaes, Claudia, Telcharova-Mihaylovska, Albena, Harjacek, Miroslav, Jelusic, Marija, Estmann, Anne, Nielsen, Susan, Herrera Mora, Cristina, Gervais, Elisabeth, Koné-Paut, Isabelle, Quartier, Pierre, Foeldvari, Ivan, Lutz, Thomas, Minden, Kirsten, Tzaribachev, Nikolay, Trachana, Maria, Tsitsami, Elena, Vougiouka, Olga, Orban, Ilonka, Harel, Liora, Hashkes, Philip, Uziel, Yosef, Cimaz, Rolando, Civino, Adele, Consolini, Rita, D'Angelo, Gianfranco, De Benedetti, Fabrizio, Filocamo, Giovanni, Fueri, Elena, Gallizzi, Romina, Maggio, Maria Cristina, Magnolia, Maria Greca, Miniaci, Angela, Montin, Davide, Olivieri, Alma Nunzia, Pastore, Serena, Rigante, Donato, Zulian, Francesco, Rumba-Rozenfelde, Ingrida, Stanevicha, Valda, Panaviene, Violeta, Rodriguez Lozano, Ana Luisa, Rubio-Perez, Nadina, Vega Cornejo, Gabriel, Hoppenreijs, Esther, Kamphuis, Sylvia, Flato, Berit, Nordal, Ellen Berit, Abdwani, Reem, Miraval, Tatiana, Paz Gastanaga, Maria Eliana, Smolewska, Elzbieta, Ailioaie, Constantin, Cochino, Alexis Virgil, Laday, Matilda, Lazar, Calin, Alexeeva, Ekaterina, Chasnyk, Vyacheslav, Keltsev, Vladimir, Suwairi, Wafaa Mohammed Saad, Vijatov-Djuric, Gordana, Vojinovic, Jelena, Arkachaisri, Thaschawee, Koskova, Elena, Avcin, Tadej, Ally, Mahmood, Van Rensburg, Christa Janse, Louw, Ingrid, Lopez, Jordi Anton, Boteanu, Alina Lucica, Calvo Penades, Inmaculada, De Inocencio, Jaime, Mesa-Del-Castillo, Pablo, Moreno, Estefania, Remesal, Agustin, Hofer, Michael, Gok, Faysal, Ozen, Seza, Ramanan, Athimalaipet, Pallotti, Chiara, Villa, Luca, Immuno/reuma patientenzorg, Child Health, Infectieziekten patientenzorg, Infection & Immunity, Cluster B, Immuno/reuma onderzoek 1 (Vastert), Immunologie/Reumatologie, Regenerative Medicine and Stem Cells, Onderzoek, Giancane, Gabriella, Swart, Joost F., Castagnola, Elio, Groll, Andreas H., Horneff, Gerd, Huppertz, Hans Iko, Lovell, Daniel J., Wolfs, Tom, Herlin, Troels, Dolezalova, Pavla, Sanner, Helga, Susic, Gordana, Sztajnbok, Flavio, Maritsi, Despoina, Constantin, Tamas, Vargova, Veronika, Sawhney, Sujata, Rygg, Marite, Oliveira, Sheila K., Cattalini, Marco, Bovis, Francesca, Bagnasco, Francesca, Pistorio, Angela, Martini, Alberto, Wulffraat, Nico, Ruperto, Nicolino, Cuttica, Ruben, Garay, Stella Maris, Brunner, Jurgen, Emminger, Wolfgang, Appenzeller, Simone, Len, Claudio, Saad Magalhaes, Claudia, Telcharova-Mihaylovska, Albena, Harjacek, Miroslav, Jelusic, Marija, Estmann, Anne, Nielsen, Susan, Herrera Mora, Cristina, Gervais, Elisabeth, Koné-Paut, Isabelle, Quartier, Pierre, Foeldvari, Ivan, Lutz, Thomas, Minden, Kirsten, Tzaribachev, Nikolay, Trachana, Maria, Tsitsami, Elena, Vougiouka, Olga, Orban, Ilonka, Harel, Liora, Hashkes, Philip, Uziel, Yosef, Cimaz, Rolando, Civino, Adele, Consolini, Rita, D'Angelo, Gianfranco, De Benedetti, Fabrizio, Filocamo, Giovanni, Fueri, Elena, Gallizzi, Romina, Maggio, Maria Cristina, Magnolia, Maria Greca, Miniaci, Angela, Montin, Davide, Olivieri, Alma Nunzia, Pastore, Serena, Rigante, Donato, Zulian, Francesco, Rumba-Rozenfelde, Ingrida, Stanevicha, Valda, Panaviene, Violeta, Rodriguez Lozano, Ana Luisa, Rubio-Perez, Nadina, Vega Cornejo, Gabriel, Hoppenreijs, Esther, Kamphuis, Sylvia, Flato, Berit, Nordal, Ellen Berit, Abdwani, Reem, Miraval, Tatiana, Paz Gastanaga, Maria Eliana, Smolewska, Elzbieta, Ailioaie, Constantin, Cochino, Alexis Virgil, Laday, Matilda, Lazar, Calin, Alexeeva, Ekaterina, Chasnyk, Vyacheslav, Keltsev, Vladimir, Suwairi, Wafaa Mohammed Saad, Vijatov-Djuric, Gordana, Vojinovic, Jelena, Arkachaisri, Thaschawee, Koskova, Elena, Avcin, Tadej, Ally, Mahmood, Van Rensburg, Christa Janse, Louw, Ingrid, Lopez, Jordi Anton, Boteanu, Alina Lucica, Calvo Penades, Inmaculada, De Inocencio, Jaime, Mesa-Del-Castillo, Pablo, Moreno, Estefania, Remesal, Agustin, Hofer, Michael, Gok, Faysal, Ozen, Seza, Ramanan, Athimalaipet, Pallotti, Chiara, and Villa, Luca

Published
2020

18. Defining clinical remission and clinically inactive disease in juvenile systemic lupus erythematosus (jSLE)

Author

Espada Graciela, Cuttica Ruben, Beresford Michael, Nelson Shannen, Yousaf Wajeeha, Levy Deborah, Tucker Lori, O’ Neil Kathleen, Singer Nora G, Onel Karen, Higgins Gloria, Klein–Gitelman Marisa, Eberhard Anne B, Schanberg Laura, Mina Rina, Ravelli Angelo, Martini Alberto, Giannini Edward, and Brunner Hermine I

Subjects
Pediatrics, RJ1-570, Diseases of the musculoskeletal system, RC925-935
Published
2011
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19. Therapeutic approaches for the treatment of renal disease in juvenile systemic lupus erythematosus: an international multicentre PRINTO study

Author

Miettunen, Paivi M, Pistorio, Angela, Palmisani, Elena, Ravelli, Angelo, Silverman, Earl, Oliveira, Sheila, Alessio, Maria, Cuttica, Ruben, Mihaylova, Dimitrina, Espada, Graciela, Pasic, Srdjan, Insalaco, Antonella, Ozen, Seza, Porras, Oscar, Sztajnbok, Flavio, Lazarevic, Dragana, Martini, Alberto, and Ruperto, Nicolino

Published
2013
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20. Randomized Trial of Tocilizumab in Systemic Juvenile Idiopathic Arthritis

Author

De Benedetti, Fabrizio, Brunner, Hermine I., Ruperto, Nicolino, Kenwright, Andrew, Wright, Stephen, Calvo, Inmaculada, Cuttica, Ruben, Ravelli, Angelo, Schneider, Rayfel, Woo, Patricia, Wouters, Carine, Xavier, Ricardo, Zemel, Lawrence, Baildam, Eileen, Burgos-Vargas, Ruben, Dolezalova, Pavla, Garay, Stella M., Merino, Rosa, Joos, Rik, Grom, Alexei, Wulffraat, Nico, Zuber, Zbigniew, Zulian, Francesco, Lovell, Daniel, and Martini, Alberto

Published
2012
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21. Efficacy and Safety of Tocilizumab in Patients with Polyarticular Juvenile Idiopathic Arthritis: Data From a Phase 3 Trial.: 1597

Author

Brunner, Hermine, Ruperto, Nicolino, Zuber, Zbigniew, Keane, Caroline, Harari, Olivier, Kenwright, Andrew, Cuttica, Ruben J., Keltsev, Vladimir, Xavier, Ricardo, Penades, Inmaculada Calvo, Nikishina, Irina, Rubio-Perez, Nadina, Alekseeva, Ekaterina, Chasnyk, Vyacheslav, Chavez, Jose, Horneff, Gerd, Opoka-Winiarska, Violetta, Quartier, Pierre, Silva, Clovis A., Silverman, Earl D., Spindler, Alberto, Lovell, D. J., Martini, Alberto, and De Benedetti, Fabrizio

Published
2012

22. EULAR/PRINTO/PRES criteria for Henoch-Schönlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part I: Overall methodology and clinical characterisation

Author

Ruperto, Nicolino, Ozen, Seza, Pistorio, Angela, Dolezalova, Pavla, Brogan, Paul, Cabral, David A, Cuttica, Ruben, Khubchandani, Raju, Lovell, Daniel J, OʼNeil, Kathleen M, Quartier, Pierre, Ravelli, Angelo, Iusan, Silvia M, Filocamo, Giovanni, Magalhães, Claudia Saad, Unsal, Erbil, Oliveira, Sheila, Bracaglia, Claudia, Bagga, Arvind, Stanevicha, Valda, Manzoni, Silvia Magni, Pratsidou, Polyxeni, Lepore, Loredana, Espada, Graciela, Paut, Isabelle Kone, Zulian, Francesco, Barone, Patrizia, Bircan, Zelal, Maldonado, Maria del, Russo, Ricardo, Vilca, Iris, Tullus, Kjell, Cimaz, Rolando, Horneff, Gerd, Anton, Jordi, Garay, Stella, Nielsen, Susan, Barbano, Giancarlo, and Martini, Alberto

Published
2010
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23. Long-term efficacy and safety of infliximab plus methotrexate for the treatment of polyarticular-course juvenile rheumatoid arthritis: findings from an open-label treatment extension

Author

Ruperto, Nicolino, Lovell, Daniel J, Cuttica, Ruben, Woo, Patricia, Meiorin, Silvia, Wouters, Carine, Silverman, Earl D, Balogh, Zsolt, Henrickson, Michael, Davidson, Joyce, Foeldvari, Ivan, Imundo, Lisa, Simonini, Gabriele, Oppermann, Joachim, Xu, Stephen, Shen, Yaung-Kaung, Visvanathan, Sudha, Fasanmade, Adedigbo, Mendelsohn, Alan, Martini, Alberto, and Giannini, Edward H

Published
2010
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24. EULAR/PRINTO/PRES criteria for Henoch-Schonlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part 1: overall methodology and clinical characterisation

Author

Ruperto, Nicolino, Ozen, Seza, Pistorio, Angela, Dolezalova, Pavla, Brogan, Paul, Cabral, David A., Cuttica, Ruben, Khubchandani, Raju, Lovell, Daniel J., O'Neil, Kathleen, Quartier, Pierre, Ravelli, Angelo, Iusan, Silvia M., Filocamo, Gioivanni, Magalhaes, Claudia Saad, Unsal, Erbil, Oliveira, Sheila, Bracaglia, Claudia, Bagga, Arvind, Stanevicha, Valda, Manzoni, Silvia Magni, Pratsidou, Polyxeni, Lepore, Loredana, Espada, Graciela, Paut, Isabelle Kone, Zulian, Francesco, Barone, Patrizia, Bircan, Zelal, del Rocio Maldonado, Maria, Russo, Ricardo, Vilca, Iris, Tullus, Kjell, Cimaz, Rolando, Horneff, Gerd, Anton, Jordi, Garay, Stella, Nielsen, Susan, Barbano, Giancarlo, and Martini, Alberto

Subjects
Schonlein-Henoch purpura -- Diagnosis, Schonlein-Henoch purpura -- Identification and classification, Schonlein-Henoch purpura -- Research, Wegener's granulomatosis -- Diagnosis, Wegener's granulomatosis -- Identification and classification, Wegener's granulomatosis -- Research, Takayasu's arteritis -- Diagnosis, Takayasu's arteritis -- Identification and classification, Takayasu's arteritis -- Research, Children -- Diseases, Children -- Diagnosis, Children -- Identification and classification, Children -- Research, Health
Published
2010

26. Toward New Classification Criteria for Juvenile Idiopathic Arthritis : First Steps, Pediatric Rheumatology International Trials Organization International Consensus

Author

Martini, Alberto, Ravelli, Angelo, Avcin, Tadej, Beresford, Michael W, Burgos-Vargas, Ruben, Cuttica, Ruben, Ilowite, Norman T, Khubchandani, Raju, Laxer, Ronald M, Lovell, Daniel J, Petty, Ross E, Wallace, Carol A, Wulffraat, Nico M, Pistorio, Angela, Ruperto, Nicolino, and Pediatric Rheumatology International Trials Organization (PRINTO)

Subjects
Rheumatology, AUTOIMMUNE DISEASES, Immunology, Immunology and Allergy, antinuclear antibodies, Juvenile idiopathic arthritis
Abstract

OBJECTIVE: To revise the current juvenile idiopathic arthritis (JIA) International League of Associations for Rheumatology (ILAR) classification criteria with an evidence-based approach, using clinical and routine laboratory measures available worldwide, to identify homogeneous clinical groups and to distinguish those forms of chronic arthritis typically seen only in children from the childhood counterpart of adult diseases. METHODS: The overall project consists of 4 steps. This work represents Step 1, a Delphi Web-based consensus and Step 2, an international nominal group technique (NGT) consensus conference for the new provisional Pediatric Rheumatology International Trials Organization JIA classification criteria. A future large data collection of at least 1000 new-onset JIA patients (Step 3) followed by analysis and NGT consensus (Step 4) will provide data for the evidence-based validation of the JIA classification criteria. RESULTS: In Step 1, three Delphi rounds of interactions were implemented to revise the 7 ILAR JIA categories. In Step 2, forty-seven questions with electronic voting were implemented to derive the new proposed criteria. Four disorders were proposed: (a) systemic JIA; (b) rheumatoid factor-positive JIA; (c) enthesitis/spondylitis-related JIA; and (d) early-onset antinuclear antibody-positive JIA. The other forms were gathered under the term "others." These will be analyzed during the prospective data collection using a list of descriptors to see whether the clustering of some of them could identify homogeneous entities. CONCLUSION: An international consensus was reached to identify different proposed homogeneous chronic disorders that fall under the historical term JIA. These preliminary criteria will be formally validated with a dedicated project.

Published
2019

27. Additional file 1: of Intravenous dosing of tocilizumab in patients younger than two years of age with systemic juvenile idiopathic arthritis: results from an open-label phase 1 clinical trial

Author

Navita Mallalieu, Sunethra Wimalasundera, Hsu, Joy, Douglass, Wendy, Wells, Chris, Penades, Inmaculada, Cuttica, Ruben, Hans-Iko Huppertz, Joos, Rik, Kimura, Yukiko, Milojevic, Diana, Rosenkranz, Margalit, Schikler, Kenneth, Constantin, Tamas, and Wouters, Carine

Abstract

Appendix 1. List of investigators and institutional review boards or ethics committees. Appendix 2. Calculation of sample size. Appendix 3. Details of patients with hypersensitivity reactions. (DOCX 59 kb)

Published
2019
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28. A randomized, placebo-controlled trial of infliximab plus methotrexate for the treatment of polyarticular-course juvenile rheumatoid arthritis

Author

Ruperto, Nicolino, Lovell, Daniel J., Cuttica, Ruben, Wilkinson, Nick, Woo, Patricia, Espada, Graciela, Wouters, Carine, Silverman, Earl D., Balogh, Zsolt, Henrickson, Michael, Apaz, Maria-Teresa, Baildam, Eileen, Fasth, Anders, Gerloni, Valeria, Lahdenne, Pekka, Prieur, Anne-Marie, Ravelli, Angelo, Saurenmann, Rotraud K., Gamir, Maria Luz, Wulffraat, Nico, Marodi, Laszlo, Petty, Ross E., Joos, Rik, Zulian, Francesco, McCurdy, Deborah, Myones, Barry L., Nagy, Kalman, Reuman, Peter, Szer, Ilona, Travers, Suzanne, Beutler, Anna, Keenan, Greg, Clark, Jason, Visvanathan, Sudha, Fasanmade, Adedigbo, Raychaudhuri, Aparna, Mendelsohn, Alan, Martini, Alberto, and Giannini, Edward H.

Published
2007

29. The Pediatric Rheumatology European Society/American College of Rheumatology/European League against Rheumatism provisional classification criteria for juvenile systemic sclerosis

Author

Zulian, Francesco, Woo, Patricia, Athreya, Balu H., Laxer, Ronald M., Medsger, Thomas A., Jr., Lehman, Thomas J. A., Cerinic, Marco Matucci, Martini, Giorgia, Ravelli, Angelo, Russo, Ricardo, Cuttica, Ruben, de Oliveira, Sheila Knupp Feitosa, Denton, Christopher P., Cozzi, Franco, Foeldvari, Ivan, and Ruperto, Nicolino

Published
2007

30. Systemic sclerosis in childhood: Clinical and immunologic features of 153 patients in an international database

Author

Martini, Giorgia, Foeldvari, Ivan, Russo, Ricardo, Cuttica, Ruben, Eberhard, Anne, Ravelli, Angelo, Lehman, Thomas J. A., de Oliveira, Sheila Knupp Feitosa, Susic, Gordana, Lyskina, Galina, Nemcova, Dana, Sundel, Robert, Falcini, Fernanda, Girschick, Herman, Lotito, Ana Paula, Buoncompagni, Antonella, Sztajnbok, Flavio, Al-Mayouf, Sulaiman M., Orbàn, Ilonka, Ferri, Clodoveo, Athreya, Balu H., Woo, Patricia, and Zulian, Francesco

Published
2006

31. The Pediatric Rheumatology International Trials Organization Criteria for the Evaluation of Response to Therapy in Juvenile Systemic Lupus Erythematosus: Prospective Validation of the Disease Activity Core Set

Author

Ruperto, Nicolino, Ravelli, Angelo, Cuttica, Ruben, Espada, Graciela, Ozen, Seza, Porras, Oscar, Sztajnbok, Flavio, Falcini, Fernanda, Kasapcopur, Ozgur, Venning, Helen, Bica, Blanca, Merino, Rosa, Coto, Cecilia, Ros, Joan, Susic, Gordana, Gamir, María Luz, Minden, Kirsten, See, Yvonne, Uziel, Yosef, Mukamel, Masha, Riley, Phil, Zulian, Francesco, Olivieri, Alma Nunzia, Cimaz, Rolando, Girschick, Hermann, Rumba, Ingrida, Cavuto, Silvio, Pistorio, Angela, Lovell, Daniel J., and Martini, Alberto

Published
2005

32. Toward New Classification Criteria for Juvenile Idiopathic Arthritis: First Steps, Pediatric Rheumatology International Trials Organization International Consensus

Author

Cluster B, Immuno/reuma onderzoek 1 (Vastert), Onderzoek, Child Health, Regenerative Medicine and Stem Cells, Infection & Immunity, Immunologie/Reumatologie, BOO, Divisieleiding O&O, Infectiezieken, Reumatologie, Reumatologie onderzoek 2, Martini, Alberto, Ravelli, Angelo, Avcin, Tadej, Beresford, Michael W, Burgos-Vargas, Ruben, Cuttica, Ruben, Ilowite, Norman T, Khubchandani, Raju, Laxer, Ronald M, Lovell, Daniel J, Petty, Ross E, Wallace, Carol A, Wulffraat, Nico M, Pistorio, Angela, Ruperto, Nicolino, Pediatric Rheumatology International Trials Organization (PRINTO), Cluster B, Immuno/reuma onderzoek 1 (Vastert), Onderzoek, Child Health, Regenerative Medicine and Stem Cells, Infection & Immunity, Immunologie/Reumatologie, BOO, Divisieleiding O&O, Infectiezieken, Reumatologie, Reumatologie onderzoek 2, Martini, Alberto, Ravelli, Angelo, Avcin, Tadej, Beresford, Michael W, Burgos-Vargas, Ruben, Cuttica, Ruben, Ilowite, Norman T, Khubchandani, Raju, Laxer, Ronald M, Lovell, Daniel J, Petty, Ross E, Wallace, Carol A, Wulffraat, Nico M, Pistorio, Angela, Ruperto, Nicolino, and Pediatric Rheumatology International Trials Organization (PRINTO)

Published
2019

33. THU0516 LONG-TERM SAFETY OF SUBCUTANEOUS TOCILIZUMAB ADMINISTRATION IN SYSTEMIC AND POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS

Author

Benedetti, Fabrizio De, primary, Ruperto, Nicolino, additional, Ramanan, Athimalaipet, additional, Cuttica, Ruben, additional, Weiss, Jennifer E., additional, Henrickson, Michael, additional, Schmeling, Heinrike, additional, Anton, Jordi, additional, Minden, Kirsten, additional, Horneff, Gerd, additional, Gámir, Maria Luz Gámir, additional, Hufnagel, Markus, additional, Douglass, Wendy, additional, Wells, Chris, additional, Mallalieu, Navita L., additional, Martini, Alberto, additional, Lovell, Daniel J, additional, and Brunner, Hermine, additional

Published
2019
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34. SAT0515 GROWTH AND DEVELOPMENT OF PATIENTS WITH POLYARTICULAR-COURSE JUVENILE IDIOPATHIC ARTHRITIS TREATED WITH SUBCUTANEOUS ABATACEPT

Author

Ruperto, Nicolino, primary, Brunner, Hermine, additional, Cornejo, Gabriel Vega, additional, Berman, Alberto, additional, Anton, Jordi, additional, Cuttica, Ruben, additional, Keltsev, Vladimir, additional, Viola, Diego Oscar, additional, Lauwerys, Bernard, additional, Rama, Maria Elena, additional, Bohnsack, John, additional, Caillaud, Caroline, additional, Minden, Kirsten, additional, Ally, Mahmood Moosa, additional, Gervais, Elisabeth, additional, Zyl, Riana Van, additional, Gandhi, Yash, additional, Murthy, Bindu, additional, Nys, Marleen, additional, Wong, Robert, additional, Hoang, Jade, additional, Martini, Alberto, additional, and Lovell, Daniel J., additional

Published
2019
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35. Phenotypic variability and disparities in treatment and outcomes of childhood arthritis throughout the world: an observational cohort study

Author

Consolaro, Alessandro, primary, Giancane, Gabriella, additional, Alongi, Alessandra, additional, van Dijkhuizen, Evert Hendrik Pieter, additional, Aggarwal, Amita, additional, Al-Mayouf, Sulaiman M, additional, Bovis, Francesca, additional, De Inocencio, Jaime, additional, Demirkaya, Erkan, additional, Flato, Berit, additional, Foell, Dirk, additional, Garay, Stella Maris, additional, Lazăr, Călin, additional, Lovell, Daniel J, additional, Montobbio, Carolina, additional, Miettunen, Paivi, additional, Mihaylova, Dimitrina, additional, Nielsen, Susan, additional, Orban, Ilonka, additional, Rumba-Rozenfelde, Ingrida, additional, Magalhães, Claudia Saad, additional, Shafaie, Nahid, additional, Susic, Gordana, additional, Trachana, Maria, additional, Wulffraat, Nico, additional, Pistorio, Angela, additional, Martini, Alberto, additional, Ruperto, Nicolino, additional, Ravelli, Angelo, additional, Abdwani, Reem, additional, Aghighi, Yahya, additional, Aiche, Maya-Feriel, additional, Ailioaie, Constantin, additional, Aktay Ayaz, Nuray, additional, Al-Abrawi, Safiya, additional, Alexeeva, Ekaterina, additional, Anton, Jordi, additional, Apostol, Adriana, additional, Arguedas, Olga, additional, Avcin, Tadej, additional, Barone, Patrizia, additional, Berntson, Lillemor, additional, Boteanu, Alina Lucica, additional, Boyko, Yaryna, additional, Burgos-Vargas, Ruben, additional, Calvo Penades, Inmaculada, additional, Chédeville, Gaëlle, additional, Cimaz, Rolando, additional, Civino, Adele, additional, Consolini, Rita, additional, Constantin, Tamas, additional, Cuttica, Ruben, additional, Dallos, Tomas, additional, Martin, Neil, additional, Magni Manzoni, Silvia, additional, De Cunto, Carmen, additional, Dolezalova, Pavla, additional, Ekelund, Maria, additional, El Miedany, Yasser, additional, Espada, Graciela, additional, Estmann Christensen, Anne, additional, Foeldvari, Ivan, additional, Gallizzi, Romina, additional, Ganser, Gerd, additional, Gerloni, Valeria, additional, Haas, Johannes-Peter, additional, Harel, Liora, additional, Harjacek, Miroslav, additional, Hashad, Soad, additional, Herlin, Troels, additional, Herrera, Cristina, additional, Hofer, Michael, additional, Holzinger, Dirk, additional, Horneff, Gerd, additional, Huppertz, Hans-Iko, additional, Iagăru, Nicolae, additional, Ibanez Estrella, Amparo, additional, Ioseliani, Maka, additional, Joos, Rik, additional, Knupp Oliveira, Sheila, additional, Kamphuis, Sylvia, additional, Kasapcopur, Ozgur, additional, Katsicas, Maria Martha, additional, Khubchandani, Raju, additional, Kondi, Anuela, additional, Kröger, Liisa, additional, La Torre, Francesco, additional, Laday, Matilda, additional, Lahdenne, Pekka, additional, Maggio, Maria Cristina, additional, Magnolia, Maria Greca, additional, Malagon, Clara, additional, Malin, Merja, additional, Martino, Silvana, additional, Melo-Gomes, Jose Antonio, additional, Mesa-del-Castillo, Pablo, additional, Militaru, Andrea, additional, Minden, Kirsten, additional, Miniaci, Angela, additional, Moradinejad, Mohammad Hasan, additional, Morel Ayala, Zoilo, additional, Nikishina, Irina, additional, Norambuena, Ximena, additional, Nordal, Ellen Berit, additional, Pagava, Karaman, additional, Panaviene, Violeta, additional, Pastore, Serena, additional, Pieropan, Sara, additional, Podda, Rosa Anna, additional, Pruunsild, Chris, additional, Putto-Laurila, Anne, additional, Quartier, Pierre, additional, Remesal, Agustin, additional, Rigante, Donato, additional, Ringold, Sarah, additional, Rutkowska-Sak, Lidia, additional, Rygg, Marite, additional, Saurenmann, Rotraud Katharina, additional, Sawhney, Sujata, additional, Scott, Christiaan, additional, Shiari, Reza, additional, Smolewska, Elzbieta, additional, Sozeri, Betul, additional, Swart, Joost Frans, additional, Sztajnbok, Flavio, additional, Torcoletti, Marta, additional, Tsitsami, Elena, additional, Tzaribachev, Nikolay, additional, Unsal, Erbil, additional, Uziel, Yosef, additional, Vähäsalo, Paula, additional, Varbanova, Boriana, additional, Vargova, Veronika, additional, Vesely, Richard, additional, Vijatov-Djuric, Gordana, additional, Vilaiyuk, Soamarat, additional, Vojinovic, Jelena, additional, Vougiouka, Olga, additional, Weiss, Pamela, additional, and Wouters, Carine, additional

Published
2019
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36. The effect of infliximab plus methotrexate on the modulation of inflammatory disease markers in juvenile idiopathic arthritis: analyses from a randomized, placebo-controlled trial

Author

Gerloni Valeria, Fasth Anders, Baildam Eileen, Apaz Maria T, Gattorno Marco, Espada Graciela, Woo Patricia, Cuttica Ruben, Petty Ross, Martini Alberto, Lovell Daniel J, Marini Joseph C, Wagner Carrie, Visvanathan Sudha, Lahdenne Pekka, Quartier Pierre, Saurenmann Rotraud, Travers Suzanne, Mendelsohn Alan, Xu Stephen, Giannini Edward H, and Ruperto Nicolino

Subjects
Pediatrics, RJ1-570, Diseases of the musculoskeletal system, RC925-935
Abstract

Abstract Background We evaluated the effect of infliximab on markers of inflammation in patients with juvenile idiopathic arthritis (JIA). Methods In this randomized, placebo-controlled substudy, 122 patients with JIA received infliximab 3 mg/kg + methotrexate (MTX)(n = 60) or placebo + MTX (n = 62) at weeks 0, 2, and 6. At week 14, patients receiving placebo + MTX crossed over to infliximab 6 mg/kg + MTX; patients receiving infliximab 3 mg/kg + MTX continued treatment through week 44. Sera and plasma from eligible patients receiving infliximab 3 mg/kg + MTX (n = 34) and receiving placebo→infliximab 6 mg/kg +MTX (n = 38) were collected at weeks 0, 2, 14, 16, 28, and 52 and analyzed for inflammatory markers (IL-6, IL-12p40, ICAM-1, MMP-3, VEGF, TNF-α, and CRP). Results At week 2, decreases from baseline in IL-6, ICAM-1, MMP-3, TNF-α, and CRP were greater with infliximab versus placebo treatment, and with the exception of CRP, these differences were generally maintained through week 14. The decreases from baseline to week 52 in IL-6, ICAM-1, VEGF, MMP-3, and CRP and increases in IL-12p40 levels were larger in patients receiving placebo→infliximab 6 mg/kg +MTX versus infliximab 3 mg/kg + MTX treatment. Patients receiving infliximab 3 mg/kg+MTX who achieved an American College of Rheumatology Pediatric 30 (ACR-Pedi-30) response had significantly larger decreases from baseline in ICAM-1 (p = 0.0105) and MMP-3 (p = 0.0253) at week 2 and in ICAM-1 (p = 0.0304), MMP-3 (p = 0.0091), and CRP (p = 0.0011) at week 14 versus ACR-Pedi-30 nonresponders. Conclusion Infliximab + MTX attenuated several inflammatory markers in patients with JIA; larger decreases in ICAM-1, MMP-3, and CRP levels were observed in ACR-Pedi-30 responders versus nonresponders. Trial Registration NCT00036374

Published
2010
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37. Long-Term Safety of Subcutaneous Tocilizumab Administration in Systemic and Polyarticular Juvenile Idiopathic Arthritis

Author

Brunner, Hermine I., Ruperto, Nicola, Martini, Alberto, Ramanan, Athimalaipet V., Cuttica, Ruben J., Weiss, Jennifer E., Henrickson, Michael, Schmeling, Heinrike, Anton, Jordi, Minden, Kirsten, Horneff, Gerd, Luz Gamir-Gamir, Maria, Hufnagel, Markus, Douglass, Wendy, Wells, Chris, Wimalasundera, Sunethra, Mallalieu, Navita L., Lovell, Daniel J., De Benedetti, Fabrizio, Brunner, Hermine I., Ruperto, Nicola, Martini, Alberto, Ramanan, Athimalaipet V., Cuttica, Ruben J., Weiss, Jennifer E., Henrickson, Michael, Schmeling, Heinrike, Anton, Jordi, Minden, Kirsten, Horneff, Gerd, Luz Gamir-Gamir, Maria, Hufnagel, Markus, Douglass, Wendy, Wells, Chris, Wimalasundera, Sunethra, Mallalieu, Navita L., Lovell, Daniel J., and De Benedetti, Fabrizio

Published
2018

38. Canakinumab in patients with systemic juvenile idiopathic arthritis and active systemic features: results from the 5-year long-term extension of the phase III pivotal trials

Author

Ruperto, Nicolino, Brunner, Hermine I., Quartier, Pierre, Constantin, Tamas, Wulffraat, Nico M., Horneff, Gerd, Kasapcopur, Ozgur, Schneider, Rayfel, Anton, Jordi, Barash, Judith, Berner, Reinhard, Corona, Fabrizia, Cuttica, Ruben, Fouillet-desjonqueres, Marine, Fischbach, Michel, Foster, Helen E., Foell, Dirk, Radominski, Sebastiao C., Ramanan, Athimalaipet V., Trauzeddel, Ralf, Unsal, Erbil, Levy, Jeremy, Vritzali, Eleni, Martini, Alberto, Lovell, Daniel J., Ruperto, Nicolino, Brunner, Hermine I., Quartier, Pierre, Constantin, Tamas, Wulffraat, Nico M., Horneff, Gerd, Kasapcopur, Ozgur, Schneider, Rayfel, Anton, Jordi, Barash, Judith, Berner, Reinhard, Corona, Fabrizia, Cuttica, Ruben, Fouillet-desjonqueres, Marine, Fischbach, Michel, Foster, Helen E., Foell, Dirk, Radominski, Sebastiao C., Ramanan, Athimalaipet V., Trauzeddel, Ralf, Unsal, Erbil, Levy, Jeremy, Vritzali, Eleni, Martini, Alberto, and Lovell, Daniel J.

Abstract

Objectives To evaluate the long-term efficacy and safety of canakinumab in patients with active systemic juvenile idiopathic arthritis (JIA). Methods Patients (2-19 years) entered two phase III studies and continued in the long-term extension (LTE) study. Efficacy assessments were performed every 3 months, including adapted JIA American College of Rheumatology (aJIA-ACR) criteria, Juvenile Arthritis Disease Activity Score (JADAS) and ACR clinical remission on medication criteria (CRACR). Efficacy analyses are reported as per the intent-to-treat population. Results 144 of the 177 patients (81%) enrolled in the core study entered the LTE. Overall, 75 patients (42%) completed and 102 (58%) discontinued mainly for inefficacy (63/102, 62%), with higher discontinuation rates noted in the late responders group (n=25/31, 81%) versus early responders (n=11/38, 29%). At 2 years, aJIA-ACR 50/70/90 response rates were 62%, 61% and 54%, respectively. CRACR was achieved by 20% of patients at month 6; 32% at 2 years. A JADAS low disease activity score was achieved by 49% of patients at 2 years. Efficacy results were maintained up to 5 years. Of the 128/177 (72.3%) patients on glucocorticoids, 20 (15.6%) discontinued and 28 (22%) tapered to 0.150 mg/kg/ day. Seven patients discontinued canakinumab due to CR. There were 13 macrophage activation syndrome (three previously reported) and no additional deaths (three previously reported). No new safety findings were observed. Conclusion Response to canakinumab treatment was sustained and associated with substantial glucocorticoid dose reduction or discontinuation and a relatively low retention-on-treatment rate. No new safety findings were observed on long-term use of canakinumab.

Published
2018

39. Multizentrische, doppelblinde, randomisierte Studie von Golimumab bei pädiatrischen Patienten mit aktiver pJIA trotz Methotrexat: Ergebnisse nach 48 Wochen

Author

Brunner, Hermine, Horneff, Gerd, Ruperto, Nicola, Tzaribachev, Nikolay, Wouters, Carine, Chasnyk, Vyacheslav, Cuttica, Ruben, Keltsev, V., Nasonov, Evgeny, Kingsbury, D., Weller-Heinemann, Frank, Lovell, Daniel J., Martini, Alberto, Panaviene, Violeta Vladislava, Abud Mendoza, Carlos, Reiff, Andreas, Alexeeva, Ekaterina, Joos, Rik, Bandeira, Márcia, Silverman, Earl, Van Royen-Kerkhof, Annet, Kim, Lilianne, and Rubio-Perez, Nadina

Subjects
ddc: 610, randomisiert, doppelblind, 610 Medical sciences, Medicine, klinische Remission, ACR30-Ansprechen, Golimumab, juvenile idiopathische Arthritis
Abstract

Einleitung: Beurteilung der Wirksamkeit und Sicherheit von Golimumab (GLM) bei pädiatrischen Patienten (2-17 Jahre) mit aktiver polyartikulärer juveniler idiopathischer Arthritis (pJIA) trotz mindestens 3-monatiger MTX-Therapie. Methoden: GO-KIDS war eine 3-phasige (P1: Wo0-16, P2: Wo16-48,[zum vollständigen Text gelangen Sie über die oben angegebene URL], 44. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 30. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 26. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2016

40. 06. Identification of optimal subcutaneous doses of tocilizumab in children with polyarticular-course juvenile idiopathic arthritis

Author

Jafri, Shazad, primary, Ramanan, Athimalaipet V., additional, De Benedetti, Fabrizio, additional, Ruperto, Nicolino, additional, Lovell, Daniel, additional, Cuttica, Ruben, additional, Weiss, Jennifer E., additional, Henrickson, Michael, additional, Schmeling, Heinrike, additional, Anton, Jordi, additional, Minden, Kirsten, additional, Hsu, Joy, additional, Bharucha, Kamal, additional, Wimalasundera, Sunethra, additional, Kadva, Alysha K., additional, Upmanyu, Ruchi, additional, Mallalieu, Navita L., additional, Martini, Alberto, additional, and Brunner, Hermine, additional

Published
2017
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41. Prednisone versus prednisone plus ciclosporin versus prednisone plus methotrexate in new-onset juvenile dermatomyositis: a randomised trial

Author

Infection & Immunity, Regenerative Medicine and Stem Cells, Child Health, Immuno/reuma patientenzorg, Ruperto, Nicolino, Pistorio, Angela, Oliveira, Sheila, Zulian, Francesco, Cuttica, Ruben, Ravelli, Angelo, Fischbach, Michel, Magnusson, Bo, Sterba, Gary, Avcin, Tadej, Brochard, Karine, Corona, Fabrizia, Dressler, Frank, Gerloni, Valeria, Apaz, Maria T, Bracaglia, Claudia, Cespedes-Cruz, Adriana, Cimaz, Rolando, Couillault, Gerard, Joos, Rik, Quartier, Pierre, Russo, Ricardo, Tardieu, Marc, Wulffraat, Nico, Bica, Blanca, Dolezalova, Pavla, Ferriani, Virginia, Flato, Berit, Bernard-Medina, Ana G, Herlin, Troels, Trachana, Maria, Meini, Antonella, Allain-Launay, Emma, Pilkington, Clarissa, Vargova, Veronika, Wouters, Carine, Angioloni, Simona, Martini, Alberto, Paediatric Rheumatology International Trials Organisation (PRINTO), Infection & Immunity, Regenerative Medicine and Stem Cells, Child Health, Immuno/reuma patientenzorg, Ruperto, Nicolino, Pistorio, Angela, Oliveira, Sheila, Zulian, Francesco, Cuttica, Ruben, Ravelli, Angelo, Fischbach, Michel, Magnusson, Bo, Sterba, Gary, Avcin, Tadej, Brochard, Karine, Corona, Fabrizia, Dressler, Frank, Gerloni, Valeria, Apaz, Maria T, Bracaglia, Claudia, Cespedes-Cruz, Adriana, Cimaz, Rolando, Couillault, Gerard, Joos, Rik, Quartier, Pierre, Russo, Ricardo, Tardieu, Marc, Wulffraat, Nico, Bica, Blanca, Dolezalova, Pavla, Ferriani, Virginia, Flato, Berit, Bernard-Medina, Ana G, Herlin, Troels, Trachana, Maria, Meini, Antonella, Allain-Launay, Emma, Pilkington, Clarissa, Vargova, Veronika, Wouters, Carine, Angioloni, Simona, Martini, Alberto, and Paediatric Rheumatology International Trials Organisation (PRINTO)

Published
2016

42. 2016 American College of Rheumatology/European League Against Rheumatism criteria for minimal, moderate, and major clinical response in juvenile dermatomyositis : An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation collaborative initiative

Author

Rider, Lisa G., Aggarwal, Rohit, Pistorio, Angela, Bayat, Nastaran, Erman, Brian, Feldman, Brian M., Huber, Adam M., Cimaz, Rolando, Cuttica, Rubén J., de Oliveira, Sheila Knupp, Lindsley, Carol B., Pilkington, Clarissa A., Punaro, Marilynn, Ravelli, Angelo, Reed, Ann M., Rouster-Stevens, Kelly, van Royen-Kerkhof, Annet, Dressler, Frank, Magalhaes, Claudia Saad, Constantin, Tamás, Davidson, Joyce E., Magnusson, Bo, Russo, Ricardo, Villa, Luca, Rinaldi, Mariangela, Rockette, Howard, Lachenbruch, Peter A., Miller, Frederick W., Vencovsky, Jiri, Ruperto, Nicolino, Hansen, Paul, Apaz, Maria, Bowyer, Suzanne, Curran, Megan, Davidson, Joyce, Griffin, Thomas, Huber, Adam H., Jones, Olcay, Kim, Susan, Lang, Bianca, Lindsley, Carol, Lovell, Daniel, Saad Magalhaes, Claudia, Pachman, Lauren M., Pilkington, Clarissa, Ponyi, Andrea, Quartier, Pierre, Ramanan, Athimalaipet V., Reed, Ann, Rennebohm, Robert, Sherry, David D., Silva, Clovis A., Stringer, Elizabeth, Wallace, Carol, Oddis, Chester V., Avcin, Tadej, Becker, Mara, Beresford, Michael W., Cuttica, Ruben, Dvergsten, Jeffrey, Feitosa de Oliveira, Sheila Knupp, Leme Ferriani, Virginia Paes, Flato, Berit, Gerloni, Valeria, Henrickson, Michael, Hinze, Claas, Hoeltzel, Mark, Ibarra, Maria, Ilowite, Norman, Imundo, Lisa, Kingsbury, Daniel, Martini, Alberto, Maguiness, Sheilagh, Maillard, Susan, Mathiesen, Pernille, Mccann, Liza, Nielsen, Susan, Passo, Murray, Rabinovich, Egla, Rivas-Chacon, Rafael, Byun Robinson, Angela, Rutkowska-Sak, Lidia, Sallum, Adriana, Sanner, Helga, Schmeling, Heinrike, Selcen, Duygu, Shaham, Bracha, Spencer, Charles H., Sundel, Robert, Tardieu, Marc, Thatayatikom, Akaluck, van der Net, Janjaap, Wahezi, Dawn, Zulian, Francesco, Analysis, Conjoint, Knupp Feitosa de Oliveira, Sheila, Cuttica, Rubén, Amato, Anthony, Chinoy, Hector, Cooper, Robert G., Dastmalchi, Maryam, de Visser, Marianne, Fiorentino, David, Isenberg, David, Katz, James, Mammen, Andrew, Ytterberg, Steven R., NIH, Univ Pittsburgh, Ist Giannina Gaslini, Social & Sci Syst Inc, Hosp Sick Children, IWK Hlth Ctr, Univ Florence, Univ Buenos Aires, Universidade Federal do Rio de Janeiro (UFRJ), Univ Kansas, Great Ormond St Hosp Sick Children, Univ Texas Dallas, Univ Genoa, Duke Univ, Emory Univ, Univ Med Ctr Utrecht, Hannover Med Sch, Universidade Estadual Paulista (Unesp), Semmelweis Univ, Royal Hosp Sick Children, Karolinska Univ Hosp, Hosp Pediatria Garrahan, Charles Univ Prague, and Neurology

Subjects
Genetics and Molecular Biology (all), Logistic regression, Severity of Illness Index, Biochemistry, 0302 clinical medicine, Fructose-Bisphosphate Aldolase, Surveys and Questionnaires, Outcome Assessment, Health Care, Immunology and Allergy, 030212 general & internal medicine, Child, Creatine Kinase, Societies, Medical, Juvenile dermatomyositis, Randomized Controlled Trials as Topic, Alanine Transaminase, Orvostudományok, Adult dermatomyositis, Conjoint analysis, Europe, Treatment Outcome, Child, Preschool, Antirheumatic Agents, Cyclosporine, Adolescent, Aspartate Aminotransferases, Dermatomyositis, Glucocorticoids, Humans, L-Lactate Dehydrogenase, Logistic Models, Methotrexate, Muscle Strength, Outcome Assessment (Health Care), Patient Reported Outcome Measures, Prednisone, Reproducibility of Results, Rheumatology, Rituximab, United States, Immunology, Adult, medicine.medical_specialty, Potentially all pairwise rankings of all possible alternatives, Consensus, Polymyositis, Klinikai orvostudományok, Sensitivity and Specificity, Article, General Biochemistry, Genetics and Molecular Biology, Autoimmune Diseases, 03 medical and health sciences, Rheumatic Diseases, Medical, Severity of illness, medicine, Preschool, 030203 arthritis & rheumatology, Myositis, Biochemistry, Genetics and Molecular Biology(all), business.industry, Gold standard, medicine.disease, Treatment, Clinical trial, Biochemistry, Genetics and Molecular Biology (all), Physical therapy, Societies, business, Rheumatism, 030217 neurology & neurosurgery, Genetics and Molecular Biology(all)
Abstract

Made available in DSpace on 2018-11-28T06:57:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-05-01 Intramural NIH HHS To develop response criteria for juvenile dermatomyositis (DM). We analysed the performance of 312 definitions that used core set measures from either the International Myositis Assessment and Clinical Studies Group (IMACS) or the Paediatric Rheumatology International Trials Organisation (PRINTO) and were derived from natural history data and a conjoint analysis survey. They were further validated using data from the PRINTO trial of prednisone alone compared to prednisone with methotrexate or cyclosporine and the Rituximab in Myositis (RIM) trial. At a consensus conference, experts considered 14 top candidate criteria based on their performance characteristics and clinical face validity, using nominal group technique. Consensus was reached for a conjoint analysis-based continuous model with a total improvement score of 0-100, using absolute per cent change in core set measures of minimal (>= 30), moderate (>= 45), and major (>= 70) improvement. The same criteria were chosen for adult DM/polymyositis, with differing thresholds for improvement. The sensitivity and specificity were 89% and 91-98% for minimal improvement, 92-94% and 94-99% for moderate improvement, and 91-98% and 85-86% for major improvement, respectively, in juvenile DM patient cohorts using the IMACS and PRINTO core set measures. These criteria were validated in the PRINTO trial for differentiating between treatment arms for minimal and moderate improvement (p= 0.009-0.057) and in the RIM trial for significantly differentiating the physician's rating for improvement (p< 0.006). The response criteria for juvenile DM consisted of a conjoint analysis-based model using a continuous improvement score based on absolute per cent change in core set measures, with thresholds for minimal, moderate, and major improvement. NIH, NIEHS, Bethesda, MD USA Univ Pittsburgh, Pittsburgh, PA 15260 USA Ist Giannina Gaslini, Genoa, Italy Social & Sci Syst Inc, Durham, NC USA Hosp Sick Children, Toronto, ON, Canada IWK Hlth Ctr, Halifax, NS, Canada Univ Florence, Florence, Italy Univ Buenos Aires, Hosp Ninos Pedro Elizalde, Buenos Aires, DF, Argentina Univ Fed Rio de Janeiro, Rio De Janeiro, Brazil Univ Kansas, Med Ctr, Kansas City, KS 66103 USA Great Ormond St Hosp Sick Children, Children NHS Trust, London, England Univ Texas Dallas, Southwester Med Ctr, Dallas, TX 75083 USA Univ Genoa, Ist Giannina Gaslini, Pediatria Reumatol 2, Genoa, Italy Duke Univ, Durham, NC 27706 USA Emory Univ, Sch Med, Atlanta, GA 30322 USA Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Utrecht, Netherlands Hannover Med Sch, Hannover, Germany Univ Estadual Paulista, Sao Paulo, Brazil Semmelweis Univ, Budapest, Hungary Royal Hosp Sick Children, Glasgow, Lanark, Scotland Royal Hosp Sick Children, Edinburgh, Midlothian, Scotland Karolinska Univ Hosp, Stockholm, Sweden Hosp Pediatria Garrahan, Buenos Aires, DF, Argentina Ist Giannina Gaslini, PRINTO, Pediatria Reumatol 2, Genoa, Italy Charles Univ Prague, Prague, Czech Republic Univ Estadual Paulista, Sao Paulo, Brazil Intramural NIH HHS: ZIA ES101081-13 Intramural NIH HHS: ZIA ES101081-14 Intramural NIH HHS: Z99 ES999999 Intramural NIH HHS: ZIA ES101081-15 Intramural NIH HHS: ZIA ES101081-12

Published
2017
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43. Efficacy and safety of tocilizumab in patients with polyarticular-course juvenile idiopathic arthritis: results from a phase 3, randomised, double-blind withdrawal trial

Author

Brunner, Hermine I., Ruperto, Nicolino, Zuber, Zbigniew, Keane, Caroline, Harari, Olivier, Kenwright, Andrew, Peng, Lu, Cuttica, Ruben, Keltsev, Vladimir, Xavier, Ricardo M., Calvo, Inmaculada, Nikishina, Irina, Rubio-Pérez, Nadina, Alexeeva, Ekaterina, Chasnyk, Vyacheslav, Horneff, Gerd, Opoka-Winiarska, Violetta, Quartier, Pierre, Silva, Clovis A., Silverman, Earl, Spindler, Alberto, Baildam, Eileen, Gámir, M. Luz, Martin, Alan, Rietschel, Christoph, Siri, Daniel, Smolewska, Elzbieta, Lovell, Daniel, Martini, Alberto, De Benedetti, Fabrizio, Sherrard, T., Johnson, A., Merritt, A., Long, W., Angioloni, Simona, Carenini, Laura, Pallotti, Chiara, Mosci, Eugenia, Garrone, Marco, Gregorini, Irene, Scala, Silvia, Villa, Luca, Silvestri, Giuseppe, Espada, Graciela, Allen, Roger, Chaitow, Jeffrey, Joos, Rik, Wouters, Carine, Knupp, Sheila, Sztajnbok, Flavio, Cabral, David, Houghton, Kristin, Roth, Johannes, Schmeling, Heinrike, Job-Deslandre, Chantal, Jorgensen, Christian, Konepaut, Isabelle, Minden, Kirsten, Weller, Frank, Gerloni, Valeria, Zulian, Francesco, Burgos-Vargas, Ruben, Salazar, Carolina Duarte, Vallejo, Eunice Solis, Calvo, Armando, Chavez, José, Zavaler, Manuel Ferrandiz, Gruenpeter, Anna, Kobusinska, Katarzyna, Sarychev, Alexey, Zholobova, Elena, Ramanan, Athimalaipet, Woo, Patricia, Gedalia, Abraham, Goodman, Steven, Kimura, Yukiko, Onel, Karen, Schikler, Kenneth, and Wouters, Carine

Subjects
Genetics and Molecular Biology (all), Male, DMARDs (biologic), Juvenile Idiopathic Arthritis, Treatment, Adolescent, Adrenal Cortex Hormones, Antibodies, Monoclonal, Humanized, Antirheumatic Agents, Arthritis, Juvenile, Bronchitis, Cellulitis, Child, Child, Preschool, Disease Progression, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Maintenance Chemotherapy, Methotrexate, Pneumonia, Receptors, Interleukin-6, Remission Induction, Treatment Outcome, Rheumatology, Immunology and Allergy, Immunology, Biochemistry, Genetics and Molecular Biology (all), Arthritis, Juvenile, Biochemistry, chemistry.chemical_compound, Monoclonal, Receptors, Medicine, skin and connective tissue diseases, Humanized, Artrite, Connective tissue disease, Rheumatoid arthritis, Combination, medicine.drug, musculoskeletal diseases, medicine.medical_specialty, General Biochemistry, Genetics and Molecular Biology, Antibodies, Tocilizumab, Drug Therapy, Internal medicine, Preschool, Imunossupressores, business.industry, Interleukin-6, Clinical and Epidemiological Research, medicine.disease, Surgery, Método duplo-cego, chemistry, business
Abstract

ObjectiveTo evaluate the interleukin-6 receptor inhibitor tocilizumab for the treatment of patients with polyarticular-course juvenile idiopathic arthritis (pcJIA).MethodsThis three-part, randomised, placebo-controlled, double-blind withdrawal study (NCT00988221) included patients who had active pcJIA for ≥6 months and inadequate responses to methotrexate. During part 1, patients received open-label tocilizumab every 4 weeks (8 or 10 mg/kg for body weight (BW) ResultsIn part 1, 188 patients received tocilizumab (ConclusionsTocilizumab treatment results in significant improvement, maintained over time, of pcJIA signs and symptoms and has a safety profile consistent with that for adults with rheumatoid arthritis.Trial registration number:NCT00988221.

Published
2014

44. Performance of Current Guidelines for Diagnosis of Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis

Author

Davi, Sergio Minoia, Francesca Pistorio, Angela Horne, AnnaCarin Consolaro, Alessandro Rosina, Silvia Bovis, Francesca Cimaz, Rolando Gamir, Maria Luz Ilowite, Norman T. and Kone-Paut, Isabelle Feitosa de Oliveira, Sheila Knupp and McCurdy, Deborah Silva, Clovis Artur Sztajnbok, Flavio and Tsitsami, Elena Unsal, Erbil Weiss, Jennifer E. Wulffraat, Nico Abinun, Mario Aggarwal, Amita Apaz, Maria Teresa and Astigarraga, Itziar Corona, Fabrizia Cuttica, Ruben and D'Angelo, Gianfranco Eisenstein, Eli M. Hashad, Soad Lepore, Loredana Mulaosmanovic, Velma Nielsen, Susan Prahalad, Sampath Rigante, Donato Stanevicha, Valda Sterba, Gary and Susic, Gordana Takei, Syuji Trauzeddel, Ralf Zletni, Mabruka and Ruperto, Nicolino Martini, Alberto Cron, Randy Q. and Ravelli, Angelo Paediat Rheumatology Int Trials Or Childhood Arthritis Rheumatology R Pediat Rheumatology Collaborative and Histiocyte Soc

Subjects
body regions, musculoskeletal diseases, fungi, lipids (amino acids, peptides, and proteins), hormones, hormone substitutes, and hormone antagonists
Abstract

ObjectiveTo compare the capacity of the 2004 diagnostic guidelines for hemophagocytic lymphohistiocytosis (HLH-2004) with the capacity of the preliminary diagnostic guidelines for systemic juvenile idiopathic arthritis (JIA)-associated macrophage activation syndrome (MAS) to discriminate MAS complicating systemic JIA from 2 potentially confusable conditions, represented by active systemic JIA without MAS and systemic infection. MethodsInternational pediatric rheumatologists and hemato-oncologists were asked to retrospectively collect clinical information from patients with systemic JIA-associated MAS and confusable conditions. The ability of the guidelines to differentiate MAS from the control diseases was evaluated by calculating the sensitivity and specificity of each set of guidelines and the kappa statistics for concordance with the physician’s diagnosis. Owing to the fact that not all patients were assessed for hemophagocytosis on bone marrow aspirates and given the lack of data on natural killer cell activity and soluble CD25 levels, the HLH-2004 guidelines were adapted to enable the diagnosis of MAS when 3 of 5 of the remaining items (3/5-adapted) or 4 of 5 of the remaining items (4/5-adapted) were present. ResultsThe study sample included 362 patients with systemic JIA and MAS, 404 patients with active systemic JIA without MAS, and 345 patients with systemic infection. The best capacity to differentiate MAS from systemic JIA without MAS was found when the preliminary MAS guidelines were applied. The 3/5-adapted HLH-2004 guidelines performed better than the 4/5-adapted guidelines in distinguishing MAS from active systemic JIA without MAS. The 3/5-adapted HLH-2004 guidelines and the preliminary MAS guidelines with the addition of ferritin levels 500 ng/ml discriminated best between MAS and systemic infections. ConclusionThe preliminary MAS guidelines showed the strongest ability to identify MAS in systemic JIA. The addition of hyperferritinemia enhanced their capacity to differentiate MAS from systemic infections. The HLH-2004 guidelines are likely not appropriate for identification of MAS in children with systemic JIA.

Published
2014

45. Health Related Quality Of Life Measure In Systemic Pediatric Rheumatic Diseases And Its Translation To Different Languages: An International Collaboration

Author

Members of our collaborative group, Moorthy, Lakshmi Nandini, Roy, Elizabeth, Kurra, Vamsi, Peterson, Margaret GE, Hassett, Afton L, Lehman, Thomas JA, Scott, Christiaan, El-Ghoneimy, Dalia, Saad, Shereen, El Feky, Reem, Al-Mayouf, Sulaiman, Dolezalova, Pavla, Malcova, Hana, Herlin, Troels, Nielsen, Susan, Wulffraat, Nico, van Royen, Annet, Marks, Stephen D, Belot, Alexandre, Brunner, Jurgen, Huemer, Christian, Foeldvari, Ivan, Horneff, Gerd, Saurenman, Traudel, Schroeder, Silke, Pratsidou-Gertsi, Polyxeni, Trachana, Maria, Uziel, Yosef, Aggarwal, Amita, Constantin, Tamas, Cimaz, Rolando, Giani, Theresa, Cantarini, Luca, Falcini, Fernanda, Manzoni, Silvia Magni, Ravelli, Angelo, Rigante, Donato, Zulian, Fracnceso, Miyamae, Takako, Yokota, Shumpei, Sato, Juliana, Magalhaes, Claudia S, Len, Claudio A, Appenzeller, Simone, Knupp, Sheila Oliveira, Rodrigues, Marta Cristine, Sztajnbok, Flavio, de Almeida, Rozana Gasparello, de Jesus, Adriana Almeida, de Arruda Campos, Lucia Maria, Silva, Clovis, Lazar, Calin, Susic, Gordana, Avcin, Tadej, Cuttica, Ruben, Burgos-Vargas, Ruben, Faugier, Enrique, Anton, Jordi, Modesto, Consuelo, Vazquez, Liza, Barillas, Lilliana, Barinstein, Laura, Sterba, Gary, Maldonado, Irama, Ozen, Seza, Kasapcopur, Ozgur, Demirkaya, Erkan, Benseler, Susa, Çocuk Sağlığı ve Hastalıkları, Rutgers State Univ, Hosp Special Surg, Univ Michigan, Red Cross War Mem Childrens Hosp, Ain Shams Univ, King Faisal Specialist Hosp & Res Ctr, Charles Univ Prague, Gen Univ Hosp, Univ Hosp Motol, Aarhus Univ, Rigshosp, Univ Med Ctr, Wilhelmina Childrens Hosp, Great Ormond St Hosp Sick Children, Lyon Univ, Med Univ Innsbruck, Prim Univ Doz, Hamburg Ctr Pediat & Adolescence Rheumatol, Asklepios Clin Sankt, Univ Zurich, Aristotle Univ Thessaloniki, Israel Meir Hosp, Sanjay Gandhi Postgrad Inst Med Sci, Semmelweis Univ, Anna Meyer Hosp, Univ Siena, Univ Florence, Osped Pediat Bambino Gesu, Univ Genoa Pediat II Reumatol, Univ Cattolica Sacro Cuore, Univ Padua, Yokohama City Univ, Universidade Estadual Paulista (Unesp), Universidade Federal de São Paulo (UNIFESP), Universidade Estadual de Campinas (UNICAMP), Universidade Federal do Rio de Janeiro (UFRJ), Univ Estado do, Universidade de São Paulo (USP), Childrens Inst, Clin Pediat I, Inst Rheumatol, Univ Childrens Hosp, Head Rheumatol Hosp Pedro Elizalde, Hosp Gen Mexico City, Hosp Infantil Mexico Fed Gomez, Hosp San Juan Dios, Hosp Univ Valle Hebron, Mt Sinai Med Ctr, Complejo Hosp Univ Ruiz & Paez, Hacettepe Univ, Istanbul Univ, FMF Arthrit Vasculitis & Orphan Dis Res Ctr, Univ Calgary, and Universitat de Barcelona

Subjects
Male, Research design, Pediatrics, Settore MED/16 - REUMATOLOGIA, Turkish, International Cooperation, German, Quality of life, immune system diseases, Surveys and Questionnaires, Immunology and Allergy, Pediatric rheumatology, Child, skin and connective tissue diseases, Language, Inflamació, humanities, Treatment Outcome, Qualitat de vida, Research Design, Child, Preschool, Antirheumatic Agents, language, Female, Immunosuppressive Agents, geographic locations, medicine.medical_specialty, Adolescent, Psychometrics, Short Report, Danish, Rheumatology, Feasibility Studies, Humans, Quality of Life, Rheumatic Diseases, Translating, medicine, Pediatrics, Perinatology, and Child Health, Reumatologia pediàtrica, Preschool, Inflammation, Lupus erythematosus, business.industry, medicine.disease, language.human_language, Family medicine, Pediatrics, Perinatology and Child Health, Xhosa, Portuguese, business
Abstract

Made available in DSpace on 2015-03-18T15:55:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-11-25Bitstream added on 2015-03-18T16:28:34Z : No. of bitstreams: 1 WOS000346520700001.pdf: 205186 bytes, checksum: c29e39dcb1d87ab0b78ebf2affc7a14b (MD5) Background: Rheumatic diseases in children are associated with significant morbidity and poor health-related quality of life (HRQOL). There is no health-related quality of life (HRQOL) scale available specifically for children with less common rheumatic diseases. These diseases share several features with systemic lupus erythematosus (SLE) such as their chronic episodic nature, multi-systemic involvement, and the need for immunosuppressive medications. HRQOL scale developed for pediatric SLE will likely be applicable to children with systemic inflammatory diseases.Findings: We adapted Simple Measure of Impact of Lupus Erythematosus in Youngsters (SMILEY (c)) to Simple Measure of Impact of Illness in Youngsters (SMILY (c)-Illness) and had it reviewed by pediatric rheumatologists for its appropriateness and cultural suitability. We tested SMILY (c)-Illness in patients with inflammatory rheumatic diseases and then translated it into 28 languages. Nineteen children (79% female, n= 15) and 17 parents participated. The mean age was 12 +/- 4 years, with median disease duration of 21 months (1-172 months). We translated SMILY (c)-Illness into the following 28 languages: Danish, Dutch, French (France), English (UK), German (Germany), German (Austria), German (Switzerland), Hebrew, Italian, Portuguese (Brazil), Slovene, Spanish (USA and Puerto Rico), Spanish (Spain), Spanish (Argentina), Spanish (Mexico), Spanish (Venezuela), Turkish, Afrikaans, Arabic (Saudi Arabia), Arabic (Egypt), Czech, Greek, Hindi, Hungarian, Japanese, Romanian, Serbian and Xhosa.Conclusion: SMILY (c)-Illness is a brief, easy to administer and score HRQOL scale for children with systemic rheumatic diseases. It is suitable for use across different age groups and literacy levels. SMILY (c)-Illness with its available translations may be used as useful adjuncts to clinical practice and research. Rutgers State Univ, Robert Wood Johnson Med Sch, New Brunswick, NJ 08903 USA Rutgers State Univ, Child Hlth Inst New Jersey, New Brunswick, NJ 08901 USA Hosp Special Surg, New York, NY 10021 USA Univ Michigan, Ann Arbor, MI 48109 USA Red Cross War Mem Childrens Hosp, Cape Town, South Africa Ain Shams Univ, Pediat Allergy Immunol & Rheumatol Unit, Cairo, Egypt Ain Shams Univ, Pediat Rheumatol Pediat Allergy Immunol & Rheum, Cairo, Egypt King Faisal Specialist Hosp & Res Ctr, Riyadh 11211, Saudi Arabia Charles Univ Prague, Prague, Czech Republic Gen Univ Hosp, Prague, Czech Republic Univ Hosp Motol, Dept Pediat, Prague, Czech Republic Aarhus Univ, Hosp Skejby, Aarhus, Denmark Rigshosp, Juliane Marie Ctr, DK-2100 Copenhagen, Denmark Univ Med Ctr, Dept Pediat Immunol, Utrecht, Netherlands Wilhelmina Childrens Hosp, Utrecht, Netherlands Great Ormond St Hosp Sick Children, Children NHS Fdn Trust, Renal Unit, London, England Lyon Univ, Hosp Civils Lyon, Rheumatol & Dermatol Dept, Lyon, France Med Univ Innsbruck, A-6020 Innsbruck, Austria Prim Univ Doz, Bregenz, Austria Hamburg Ctr Pediat & Adolescence Rheumatol, Hamburg, Germany Asklepios Clin Sankt, Augustin, Germany Univ Zurich, Childrens Hosp, Zurich, Switzerland Aristotle Univ Thessaloniki, Pediat Immunol & Rheumatol Referral Ctr, GR-54006 Thessaloniki, Greece Israel Meir Hosp, Kefar Sava, Israel Sanjay Gandhi Postgrad Inst Med Sci, Lucknow, Uttar Pradesh, India Semmelweis Univ, H-1085 Budapest, Hungary Anna Meyer Hosp, Florence, Italy Univ Siena, Res Ctr System Autoimmune & Autoinflammatory Dis, I-53100 Siena, Italy Univ Florence, Florence, Italy Osped Pediat Bambino Gesu, IRCCS, Pediat Rheumatol Unit, Rome, Italy Univ Genoa Pediat II Reumatol, Ist G Gaslini EULAR, Ctr Excellence Rheumatol, Genoa, Italy Univ Cattolica Sacro Cuore, Inst Pediat, Rome, Italy Univ Padua, Dept Pediat, Pediat Rheumatol Unit, Padua, Italy Yokohama City Univ, Sch Med, Yokohama, Kanagawa 232, Japan Univ Estadual Paulista, UNESP, Botucatu, SP, Brazil Univ Fed Sao Paulo, Dept Pediat, Sao Paulo, Brazil Univ Estadual Campinas, Dept Med, Campinas, SP, Brazil Univ Fed Rio de Janeiro, Dept Pediat, Rio De Janeiro, Brazil Univ Estado do, Adolescent Hlth Care Unit, Div Pediat Rheumatol, Rio De Janeiro, Brazil Univ Sao Paulo, Fac Med, Childrens Inst, Dept Pediat,Pediat Rheumatol Unit, Sao Paulo, Brazil Childrens Inst, Pediat Rheumatol Unit, Sao Paulo, Brazil Clin Pediat I, Cluj Napoca, Romania Inst Rheumatol, Belgrade, Serbia Univ Childrens Hosp, Univ Med Ctr Ljubljana, Ljubljana, Slovenia Head Rheumatol Hosp Pedro Elizalde, Buenos Aires, DF, Argentina Hosp Gen Mexico City, Mexico City, DF, Mexico Hosp Infantil Mexico Fed Gomez, Mexico City, DF, Mexico Hosp San Juan Dios, Barcelona, Spain Hosp Univ Valle Hebron, Barcelona, Spain Mt Sinai Med Ctr, New York, NY 10029 USA Mt Sinai Med Ctr, Miami Beach, FL 33140 USA Complejo Hosp Univ Ruiz & Paez, Bolivar, Venezuela Hacettepe Univ, Dept Pediat, Ankara, Turkey Istanbul Univ, Cerrahpasa Med Sch, Istanbul, Turkey FMF Arthrit Vasculitis & Orphan Dis Res Ctr, Inst Hlth Sci, Ankara, Turkey Univ Calgary, Dept Pediat, Alberta Childrens Hosp, Res Inst, Calgary, AB T2N 1N4, Canada Univ Estadual Paulista, UNESP, Botucatu, SP, Brazil

Published
2014
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46. The effect of infliximab plus methotrexate on the modulation of inflammatory disease markers in juvenile idiopathic arthritis: analyses from a randomized, placebo-controlled trial

Author

Visvanathan, Sudha, Wagner, Carrie, Marini, Joseph C., Lovell, Daniel J., Martini, Alberto, Petty, Ross, Cuttica, Ruben, Woo, Patricia, Espada, Graciela, Gattorno, Marco, Apaz, Maria T., Baildam, Eileen, Fasth, Anders, Gerloni, Valeria, Lahdenne, Pekka, Quartier, Pierre, Saurenmann, Rotraud, Travers, Suzanne, Mendelsohn, Alan, Xu, Stephen, Giannini, Edward H., Ruperto, Nicoline, PRINTO, PRCSG, Children's Hospital, and HUS Children and Adolescents

Subjects
musculoskeletal diseases, medicine.medical_specialty, lcsh:Diseases of the musculoskeletal system, education, Placebo-controlled study, Arthritis, Inflammation, CHILDREN, 312 Clinical medicine, Gastroenterology, SERUM, 03 medical and health sciences, 0302 clinical medicine, SYNOVIAL-FLUID, Rheumatology, SOLUBLE ADHESION MOLECULES, immune system diseases, Internal medicine, Immunology and Allergy, Medicine, Synovial fluid, 030212 general & internal medicine, skin and connective tissue diseases, 030203 arthritis & rheumatology, business.industry, Research, CYTOKINES, lcsh:RJ1-570, lcsh:Pediatrics, medicine.disease, Infliximab, 3. Good health, RHEUMATOID-ARTHRITIS, TISSUE, Rheumatoid arthritis, Pediatrics, Perinatology and Child Health, Methotrexate, medicine.symptom, lcsh:RC925-935, business, medicine.drug
Abstract

Background We evaluated the effect of infliximab on markers of inflammation in patients with juvenile idiopathic arthritis (JIA). Methods In this randomized, placebo-controlled substudy, 122 patients with JIA received infliximab 3 mg/kg + methotrexate (MTX)(n = 60) or placebo + MTX (n = 62) at weeks 0, 2, and 6. At week 14, patients receiving placebo + MTX crossed over to infliximab 6 mg/kg + MTX; patients receiving infliximab 3 mg/kg + MTX continued treatment through week 44. Sera and plasma from eligible patients receiving infliximab 3 mg/kg + MTX (n = 34) and receiving placebo→infliximab 6 mg/kg +MTX (n = 38) were collected at weeks 0, 2, 14, 16, 28, and 52 and analyzed for inflammatory markers (IL-6, IL-12p40, ICAM-1, MMP-3, VEGF, TNF-α, and CRP). Results At week 2, decreases from baseline in IL-6, ICAM-1, MMP-3, TNF-α, and CRP were greater with infliximab versus placebo treatment, and with the exception of CRP, these differences were generally maintained through week 14. The decreases from baseline to week 52 in IL-6, ICAM-1, VEGF, MMP-3, and CRP and increases in IL-12p40 levels were larger in patients receiving placebo→infliximab 6 mg/kg +MTX versus infliximab 3 mg/kg + MTX treatment. Patients receiving infliximab 3 mg/kg+MTX who achieved an American College of Rheumatology Pediatric 30 (ACR-Pedi-30) response had significantly larger decreases from baseline in ICAM-1 (p = 0.0105) and MMP-3 (p = 0.0253) at week 2 and in ICAM-1 (p = 0.0304), MMP-3 (p = 0.0091), and CRP (p = 0.0011) at week 14 versus ACR-Pedi-30 nonresponders. Conclusion Infliximab + MTX attenuated several inflammatory markers in patients with JIA; larger decreases in ICAM-1, MMP-3, and CRP levels were observed in ACR-Pedi-30 responders versus nonresponders. Trial Registration NCT00036374

Published
2010

47. The Paediatric Rheumatology International Trials Organisation provisional criteria for the evaluation of response to therapy in juvenile dermatomyositis

Author

Ruperto, Nicolino, Pistorio, Angela, Ravelli, Angelo, Rider, Lisa G, Pilkington, Clarissa, Oliveira, Sheila, Wulffraat, Nico, Espada, Graciela, Garay, Stella, Cuttica, Ruben, Hofer, Michael, Quartier, Pierre, Melo-Gomes, Jose, Reed, Ann M, Wierzbowska, Malgorzata, Feldman, Brian M, Harjacek, Miroslav, Huppertz, Hans-Iko, Nielsen, Susan Mary, Flato, Berit, Lahdenne, Pekka, Michels, Harmut, Murray, Kevin J, Punaro, Lynn, Rennebohm, Robert, Russo, Ricardo, Balogh, Zsolt, Rooney, Madeleine, Pachman, Lauren M, Wallace, Carol, Hashkes, Philip, Lovell, Daniel J, Giannini, Edward H, Gare, Boel Andersson, Martini, Alberto, Ruperto, Nicolino, Pistorio, Angela, Ravelli, Angelo, Rider, Lisa G, Pilkington, Clarissa, Oliveira, Sheila, Wulffraat, Nico, Espada, Graciela, Garay, Stella, Cuttica, Ruben, Hofer, Michael, Quartier, Pierre, Melo-Gomes, Jose, Reed, Ann M, Wierzbowska, Malgorzata, Feldman, Brian M, Harjacek, Miroslav, Huppertz, Hans-Iko, Nielsen, Susan Mary, Flato, Berit, Lahdenne, Pekka, Michels, Harmut, Murray, Kevin J, Punaro, Lynn, Rennebohm, Robert, Russo, Ricardo, Balogh, Zsolt, Rooney, Madeleine, Pachman, Lauren M, Wallace, Carol, Hashkes, Philip, Lovell, Daniel J, Giannini, Edward H, Gare, Boel Andersson, and Martini, Alberto

Abstract

To develop a provisional definition for the evaluation of response to therapy in juvenile dermatomyositis (DM) based on the Paediatric Rheumatology International Trials Organisation juvenile DM core set of variables.

Published
2010

48. Defining clinical remission and clinically inactive disease in juvenile systemic lupus erythematosus (jSLE)

Author

Mina, Rina, primary, Schanberg, Laura, additional, Eberhard, Anne B, additional, Klein–Gitelman, Marisa, additional, Higgins, Gloria, additional, Onel, Karen, additional, Singer, Nora G, additional, O’Neil, Kathleen, additional, Tucker, Lori, additional, Levy, Deborah, additional, Yousaf, Wajeeha, additional, Nelson, Shannen, additional, Beresford, Michael, additional, Cuttica, Ruben, additional, Espada, Graciela, additional, Ravelli, Angelo, additional, Martini, Alberto, additional, Giannini, Edward, additional, and Brunner, Hermine I, additional

Published
2011
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49. The Paediatric Rheumatology International Trials Organisation provisional criteria for the evaluation of response to therapy in juvenile dermatomyositis

Author

Ruperto, Nicolino, primary, Pistorio, Angela, additional, Ravelli, Angelo, additional, Rider, Lisa G., additional, Pilkington, Clarissa, additional, Oliveira, Sheila, additional, Wulffraat, Nico, additional, Espada, Graciela, additional, Garay, Stella, additional, Cuttica, Ruben, additional, Hofer, Michael, additional, Quartier, Pierre, additional, Melo-Gomes, Jose, additional, Reed, Ann M., additional, Wierzbowska, Malgorzata, additional, Feldman, Brian M., additional, Harjacek, Miroslav, additional, Huppertz, Hans-Iko, additional, Nielsen, Susan, additional, Flato, Berit, additional, Lahdenne, Pekka, additional, Michels, Harmut, additional, Murray, Kevin J., additional, Punaro, Lynn, additional, Rennebohm, Robert, additional, Russo, Ricardo, additional, Balogh, Zsolt, additional, Rooney, Madeleine, additional, Pachman, Lauren M., additional, Wallace, Carol, additional, Hashkes, Philip, additional, Lovell, Daniel J., additional, Giannini, Edward H., additional, Gare, Boel Andersson, additional, and Martini, Alberto, additional

Published
2010
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50. Long-term outcome and prognostic factors of juvenile dermatomyositis: A multinational, multicenter study of 490 patients

Author

Ravelli, Angelo, primary, Trail, Lucia, additional, Ferrari, Cristina, additional, Ruperto, Nicolino, additional, Pistorio, Angela, additional, Pilkington, Clarissa, additional, Maillard, Susan, additional, Oliveira, Sheila K., additional, Sztajnbok, Flavio, additional, Cuttica, Ruben, additional, Beltramelli, Matilde, additional, Corona, Fabrizia, additional, Katsicas, Maria Martha, additional, Russo, Ricardo, additional, Ferriani, Virginia, additional, Burgos-Vargas, Ruben, additional, Magni-Manzoni, Silvia, additional, Solis-Valleoj, Eunice, additional, Bandeira, Marcia, additional, Zulian, Francesco, additional, Baca, Vicente, additional, Cortis, Elisabetta, additional, Falcini, Fernanda, additional, Alessio, Maria, additional, Alpigiani, Maria Giannina, additional, Gerloni, Valeria, additional, Saad-Magalhaes, Claudia, additional, Podda, Rosanna, additional, Silva, Clovis A., additional, Lepore, Loredana, additional, Felici, Enrico, additional, Rossi, Federica, additional, Sala, Elena, additional, and Martini, Alberto, additional

Published
2010
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