Search

Your search keyword '"Cutini, Ilaria"' showing total 31 results
Start Over Author "Cutini, Ilaria"
31 results on '"Cutini, Ilaria"'

1. Axicabtagene ciloleucel treatment is more effective in primary mediastinal large B-cell lymphomas than in diffuse large B-cell lymphomas: the Italian CART-SIE study

Author

Chiappella, Annalisa, Casadei, Beatrice, Chiusolo, Patrizia, Di Rocco, Alice, Ljevar, Silva, Magni, Martina, Angelillo, Piera, Barbui, Anna Maria, Cutini, Ilaria, Dodero, Anna, Bonifazi, Francesca, Tisi, Maria Chiara, Bramanti, Stefania, Musso, Maurizio, Farina, Mirko, Martino, Massimo, Novo, Mattia, Grillo, Giovanni, Patriarca, Francesca, Zacchi, Giulia, Krampera, Mauro, Pennisi, Martina, Galli, Eugenio, Martelli, Maurizio, Ferreri, Andrés J. M., Ferrari, Silvia, Saccardi, Riccardo, Bermema, Anisa, Guidetti, Anna, Miceli, Rosalba, Zinzani, Pier Luigi, and Corradini, Paolo

Published
2024
Full Text
View/download PDF

2. Busulfan or Treosulfan Conditioning Platform for Allogeneic Stem Cell Transplantation in Patients Aged >60 Y With Acute Myeloid Leukemia/Myelodysplastic Syndrome: A Subanalysis of the GITMO AlloEld Study

Author

Malagola, Michele, Polverelli, Nicola, Martino, Massimo, Patriarca, Francesca, Bruno, Benedetto, Giaccone, Luisa, Grillo, Giovanni, Bramanti, Stefania, Bernasconi, Paolo, De Gobbi, Marco, Natale, Annalisa, Terruzzi, Elisabetta, Olivieri, Attilio, Chiusolo, Patrizia, Carella, Angelo Michele, Casini, Marco, Maffini, Enrico, Nozzoli, Chiara, Mazza, Patrizio, Bassi, Simona, Onida, Francesco, Vacca, Adriana, Falcioni, Sadia, Luppi, Mario, Iori, Anna Paola, Pavone, Vincenzo, Skert, Cristina, Carluccio, Paola, Borghero, Carlo, Proia, Anna, Selleri, Carmine, Rubini, Vicky, Sacchi, Nicoletta, Oldani, Elena, Bonifazi, Francesca, Ciceri, Fabio, Russo, Domenico, Bernardi, Simona, Farina, Mirko, Fiore, Maria, Lupo Stanghellini, Maria Teresa, Fanin, Renato, Faraci, Danilo Giuseppe, Castagna, Luca, Colombo, Anna Amelia, Nicoli, Paolo, Santarone, Stella, Scortechini, Ilaria, Metafuni, Elisabetta, Merla, Emanuela, Cavattoni, Irene, Cutini, Ilaria, Mazzone, Annamaria, Saporiti, Giorgia, Canale, Filippo Antonio, Piras, Eugenia, Galieni, Piero, Debbia, Giulia, Rocca, Ursula La, Mele, Anna, Carobolante, Francesca, Elice, Francesca, and Fanelli, Fulvia

Published
2023
Full Text
View/download PDF

6. S231: PRIMARY MEDIASTINAL B-CELL LYMPHOMA HAVE A SUPERIOR OUTCOME COMPARED TO DIFFUSE LARGE-B-CELL LYMPHOMA TREATED WITH AXICABTAGENE CILOLEUCEL IN THE CART-SIE REAL LIFE ITALIAN STUDY

Author

Chiappella, Annalisa, primary, Dodero, Anna, additional, Guidetti, Anna, additional, Ljevar, Silva, additional, Pennisi, Martina, additional, Casadei, Beatrice, additional, Galli, Eugenio, additional, Rocco, Alice DI, additional, Cutini, Ilaria, additional, Barbui, Anna Maria, additional, Bramanti, Stefania, additional, Musso, Maurizio, additional, Tisi, Maria Chiara, additional, Carrabba, Matteo Giovanni, additional, Martino, Massimo, additional, Farina, Mirko, additional, Botto, Barbara, additional, Grillo, Giovanni, additional, Ladetto, Marco, additional, Olivieri, Jacopo, additional, Arcaini, Luca, additional, Bermema, Anisa, additional, Miceli, Rosalba, additional, Chiusolo, Patrizia, additional, Zinzani, Pier Luigi, additional, and Corradini, Paolo, additional

Published
2023
Full Text
View/download PDF

7. S228: POSITRON EMISSION TOMOGRAPHY EVALUATION IN A LARGE GROUP OF PATIENTS AFFECTED BY RELAPSED/REFRACTORY B-CELL LYMPHOMAS TREATED WITH ANTI-19 CHIMERIC ANTIGEN RECEPTOR (CAR) T-CELLS THERAPY (CART SIE).

Author

Dodero, Anna, primary, Guidetti, Anna, additional, Chiappella, Annalisa, additional, Ljevar, Silva, additional, Pennisi, Martina, additional, Zinzani, Pier Luigi, additional, Casadei, Beatrice, additional, Bramanti, Stefania, additional, Santoro, Armando, additional, Chiusolo, Patrizia, additional, Rocco, Alice DI, additional, Palma, Martina DI, additional, Tisi, Maria Chiara, additional, Cutini, Ilaria, additional, Carrabba, Matteo, additional, Musso, Maurizio, additional, Martino, Massimo, additional, Barbui, Anna Maria, additional, Novo, Mattia, additional, Grillo, Giovanni, additional, Battista, Martalisa, additional, Zanni, Manuela, additional, Arcaini, Luca, additional, Miceli, Rosalba, additional, Magni, Martina, additional, Carniti, Cristiana, additional, and Corradini, Paolo, additional

Published
2023
Full Text
View/download PDF

8. P1081: A MULTICENTER OBSERVATIONAL STUDY ON CHIMERIC ANTIGEN RECEPTOR T-CELL THERAPY FOR LARGE B-CELL (LBCL) AND MANTLE CELL (MCL) LYMPHOMAS: THE ITALIAN CART-SIE REAL LIFE EXPERIENCE

Author

Chiappella, Annalisa, primary, Dodero, Anna, additional, Ljevar, Silva, additional, Pennisi, Martina, additional, Bonifazi, Francesca, additional, De Philippis, Chiara, additional, Galli, Eugenio, additional, Rocco, Alice DI, additional, Chiara Tisi, Maria, additional, Cutini, Ilaria, additional, Giovanni Carrabba, Matteo, additional, Musso, Maurizio, additional, Martino, Massimo, additional, Maria Barbui, Anna, additional, Botto, Barbara, additional, Farina, Mirko, additional, Grillo, Giovanni, additional, Patriarca, Francesca, additional, Ladetto, Marco, additional, Arcaini, Luca, additional, Bermema, Anisa, additional, Miceli, Rosalba, additional, Magni, Martina, additional, Martelli, Maurizio, additional, Chiusolo, Patrizia, additional, Bramanti, Stefania, additional, Luigi Zinzani, Pier, additional, Carniti, Cristiana, additional, and Corradini, Paolo, additional

Published
2023
Full Text
View/download PDF

10. 1464. Real-World (RW) Utilization Pattern of Letermovir in Adult Cytomegalovirus Seropositive Allogeneic Hematopoietic Stem Cell Transplant (HCT) Recipients: A Multicenter Retrospective Cohort Study from the European Society for Blood and Marrow Transplantation (EBMT) Registry

Author

Styczynski, Jan, primary, Tridello, Gloria, additional, Knelange, Nina, additional, Wendel, Lotus, additional, Xhaard, Alienor, additional, Cutini, Ilaria, additional, Chiusolo, Patrizia, additional, Franke, Georg-Nikolaus, additional, Kraus, Sabina, additional, Raval, Amit D, additional, Merchant, Sanjay, additional, and de la Camara, Rafael, additional

Published
2022
Full Text
View/download PDF

11. Overall Survival Improvement Following ALLO-SCT in Patients Older THAN 60 YEARS: A Gruppo Italiano Trapianto DI Midollo Osseo (GITMO) Registry Study

Author

Malagola, Michele, primary, Polverelli, Nicola, additional, Martino, Massimo, additional, Rubini, Vicky, additional, Lupo Stanghellini, Maria Teresa, additional, Patriarca, Francesca, additional, Fanin, Renato, additional, Bruno, Benedetto, additional, Giaccone, Luisa, additional, Faraci, Danilo Giuseppe, additional, Grillo, Giovanni, additional, Bramanti, Stefania, additional, Castagna, Luca, additional, Bernasconi, Paolo, additional, Colombo, Anna Amelia, additional, De Gobbi, Marco, additional, Nicoli, Paolo, additional, Natale, Annalisa, additional, Santarone, Stella, additional, Terruzzi, Elisabetta, additional, Olivieri, Attilio, additional, Scortechini, Ilaria, additional, Chiusolo, Patrizia, additional, Metafuni, Elisabetta, additional, Carella, Angelo Michele, additional, Merla, Emanuela, additional, Casini, Marco, additional, Cavattoni, Irene M, additional, Arpinati, Mario, additional, Nozzoli, Chiara, additional, Cutini, Ilaria, additional, Mazza, Patrizio, additional, Mazzone, Annamaria, additional, Bassi, Simona, additional, Onida, Francesco, additional, Saporiti, Giorgia, additional, Canale, Filippo Antonio, additional, Vacca, Adriana, additional, Piras, Eugenia, additional, Galieni, Piero, additional, Falcioni, Sadia, additional, Luppi, Mario, additional, Debbia, Giulia, additional, Iori, Anna Paola, additional, La Rocca, Ursula, additional, Pavone, Vincenzo, additional, Mele, Anna, additional, Skert, Cristina, additional, Carobolante, Francesca, additional, Carluccio, Paola, additional, Borghero, Carlo, additional, Elice, Francesca, additional, Proia, Anna, additional, Fanelli, Fulvia, additional, Selleri, Carmine, additional, Sacchi, Nicoletta, additional, Mammoliti, Sonia, additional, Oldani, Elena, additional, Ciceri, Fabio, additional, Bonifazi, Francesca, additional, and Russo, Domenico, additional

Published
2021
Full Text
View/download PDF

13. Early peripheral blast cell clearance predicts minimal residual disease status and refines disease prognosis in acute myeloid leukemia

Author

Mannelli, Francesco, primary, Gianfaldoni, Giacomo, additional, Bencini, Sara, additional, Piccini, Matteo, additional, Cutini, Ilaria, additional, Bonetti, Maria Ida, additional, Scappini, Barbara, additional, Pancani, Fabiana, additional, Ponziani, Vanessa, additional, Chiarini, Marco, additional, Borlenghi, Erika, additional, Bassan, Renato, additional, Rossi, Giuseppe, additional, and Bosi, Alberto, additional

Published
2020
Full Text
View/download PDF

14. Myeloma plasma cell Multiparametric Flow Cytometry (MFC) detection in autograft products of Newly Diagnosed Multiple Myeloma (NDMM).

Author

Boncompagni, Riccardo, primary, Staderini, Michela, additional, Nozzoli, Chiara, additional, Antonioli, Elisabetta, additional, Caporale, Roberto, additional, Peruzzi, Benedetta, additional, Jance, Blerina, additional, Francesco, Annunziato, additional, Guidi, Stefano, additional, Gozzini, Antonella, additional, Cutini, Ilaria, additional, Serena, Mariotti, additional, Bosi, Alberto, additional, and Saccardi, Riccardo, additional

Published
2019
Full Text
View/download PDF

15. Minimal Residual Disease (MRD) ratio before and after Autologous Stem Cell Transplantation (ASCT) in Multiple Myeloma.

Author

Boncompagni, Riccardo, primary, Staderini, Michela, additional, Nozzoli, Chiara, additional, Antonioli, Elisabetta, additional, Caporale, Roberto, additional, Peruzzi, Benedetta, additional, Cutini, Ilaria, additional, Gozzini, Antonella, additional, Serena, Mariotti, additional, Guidi, Stefano, additional, Jance, Blerina, additional, Accogli, Barbara, additional, Francesco, Annunziato, additional, Bosi, Alberto, additional, and Saccardi, Riccardo, additional

Published
2019
Full Text
View/download PDF

17. CEBPA –double-mutated acute myeloid leukemia displays a unique phenotypic profile: a reliable screening method and insight into biological features

Author

Mannelli, Francesco, primary, Ponziani, Vanessa, additional, Bencini, Sara, additional, Bonetti, Maria Ida, additional, Benelli, Matteo, additional, Cutini, Ilaria, additional, Gianfaldoni, Giacomo, additional, Scappini, Barbara, additional, Pancani, Fabiana, additional, Piccini, Matteo, additional, Rondelli, Tommaso, additional, Caporale, Roberto, additional, Gelli, Anna Maria Grazia, additional, Peruzzi, Benedetta, additional, Chiarini, Marco, additional, Borlenghi, Erika, additional, Spinelli, Orietta, additional, Giupponi, Damiano, additional, Zanghì, Pamela, additional, Bassan, Renato, additional, Rambaldi, Alessandro, additional, Rossi, Giuseppe, additional, and Bosi, Alberto, additional

Published
2016
Full Text
View/download PDF

18. Progression-Free Survival but Not Overall Survival Is Superior in Relapsed/Refractory Large B-Cell Lymphomas Treated with Axicabtagene Ciloleucel Compared to Tisagenlecleucel: Results of the CART-SIE Real Life Italian Study

Author

Chiappella, Annalisa, Dodero, Anna, Casadei, Beatrice, De Philippis, Chiara, Ljevar, Silva, Galli, Eugenio, Di Rocco, Alice, Carrabba, Matteo Giovanni, Tisi, Maria Chiara, Musso, Maurizio, Cutini, Ilaria, Barbui, Anna Maria, Farina, Mirko, Martino, Massimo, Guidetti, Anna, Botto, Barbara, Grillo, Giovanni, Olivieri, Jacopo, Pennisi, Martina, Krampera, Mauro, Ladetto, Marco, Massaia, Massimo, Arcaini, Luca, Cavallo, Federica, Miceli, Rosalba, Martelli, Maurizio, Chiusolo, Patrizia, Bramanti, Stefania, Zinzani, Pier Luigi, and Corradini, Paolo

Abstract

Introduction

Published
2023
Full Text
View/download PDF

19. Positron Emission Tomography Evaluation in Relapsed/Refractory B-Cell Lymphoma Patients Treated with Anti-19 Chimeric Antigen Receptor (CAR) T-Cells in the CART-SIE Observational Study

Author

Dodero, Anna, Guidetti, Anna, Chiappella, Annalisa, Ljevar, Silva, Zinzani, Pier Luigi, Casadei, Beatrice, Bramanti, Stefania, Santoro, Armando, Chiusolo, Patrizia, Di Rocco, Alice, Di Palma, Martina, Tisi, Maria Chiara, Cutini, Ilaria, Carrabba, Matteo Giovanni, Musso, Maurizio, Martino, Massimo, Barbui, Anna Maria, Novo, Mattia, Grillo, Giovanni, Battista, Marta Lisa, Zanni, Manuela, Arcaini, Luca, Miceli, Rosalba, Carniti, Cristiana, and Corradini, Paolo

Abstract

Background: CD19 direct chimeric antigen receptor (CAR) T-cell therapy is an efficacious therapy for patients (pts) affected by relapsed/refractory (R/R) large B-cell lymphomas (LBCL). The role of early evaluation by Positron emission tomography/computed tomography (PET/CT) is still undefined. The study's objective was to analyze the role of early PET/CT according to histology and CAR T-cell product administered.

Published
2023
Full Text
View/download PDF

20. Diagnosis of a T-lineage acute lymphoblastic leukemia through digitalized cell analysis of the pleural effusion

Author

Peruzzi, Benedetta, Cutini,Ilaria, Gelli, Rondelli, Statello, Bencini,Sara, Mannelli,Francesco, Caporale, Fanelli, and Bosi,Alberto

Subjects
International Medical Case Reports Journal
Abstract

Benedetta Peruzzi,1 Ilaria Cutini,2 Anna Maria Grazia Gelli,1 Tommaso Rondelli,1 Marinella Statello,1 Sara Bencini,2 Francesco Mannelli,2 Roberto Caporale,1 Alberto Bosi,2 Alessandra Fanelli1 1General Laboratory Unit (Microscopy and Clinical Cytometry Unit), 2Hematology Unit, Azienda Ospedaliero–Universitaria Careggi, Firenze, Italy Introduction: Pleural effusion as the first clinical manifestation of acute lymphoblastic leukemia (ALL) is a relatively rare event. An early and accurate diagnosis of this clinical picture is very important for adequate patient management. Case presentation: We report the atypical onset of T-lineage ALL in a 31-year-old man. The patient was admitted to the emergency room due to lung failure; at that moment, the patient's initial blood count was normal; the chest X-ray radiography showed a massive pleural effusion and a thoracentesis was carried out. Routine investigations performed on the pleural fluid using a new technology system and digitalized cell analysis demonstrated infiltration by immature cells. Therefore, bone marrow aspirate and flow cytometry analyses were performed, leading to the diagnosis of T-lineage ALL. A cord blood transplantation procedure was performed at the first hematological remission following chemotherapy regimens. The patient died of septic shock. Conclusion: The case we reported underlines the usefulness of using automated instruments to identify abnormal lymphoid cells in body fluids. Keywords: pleural effusion, digital morphology, leukemia

Published
2013

21. Multilineage dysplasia as assessed by immunophenotype has no impact on clinical-biological features and outcome of NPM1-mutated acute myeloid leukemia

Author

Mannelli, Francesco, primary, Ponziani, Vanessa, additional, Bonetti, Maria Ida, additional, Bencini, Sara, additional, Cutini, Ilaria, additional, Gianfaldoni, Giacomo, additional, Scappini, Barbara, additional, Pancani, Fabiana, additional, Rondelli, Tommaso, additional, Benelli, Matteo, additional, Caporale, Roberto, additional, Grazia Gelli, Anna Maria, additional, Peruzzi, Benedetta, additional, Longo, Giovanni, additional, and Bosi, Alberto, additional

Published
2015
Full Text
View/download PDF

23. Diagnosis of a T-lineage acute lymphoblastic leukemia through digitalized cell analysis of the pleural effusion

Author

Peruzzi,Benedetta, Cutini,Ilaria, Gelli,Anna Maria Grazia, Rondelli,Tommaso, Statello,Marinella, Bencini,Sara, Mannelli,Francesco, Caporale,Roberto, Bosi,Alberto, Fanelli,Alessandra, Peruzzi,Benedetta, Cutini,Ilaria, Gelli,Anna Maria Grazia, Rondelli,Tommaso, Statello,Marinella, Bencini,Sara, Mannelli,Francesco, Caporale,Roberto, Bosi,Alberto, and Fanelli,Alessandra

Abstract

Benedetta Peruzzi,1 Ilaria Cutini,2 Anna Maria Grazia Gelli,1 Tommaso Rondelli,1 Marinella Statello,1 Sara Bencini,2 Francesco Mannelli,2 Roberto Caporale,1 Alberto Bosi,2 Alessandra Fanelli1 1General Laboratory Unit (Microscopy and Clinical Cytometry Unit), 2Hematology Unit, Azienda Ospedaliero–Universitaria Careggi, Firenze, Italy Introduction: Pleural effusion as the first clinical manifestation of acute lymphoblastic leukemia (ALL) is a relatively rare event. An early and accurate diagnosis of this clinical picture is very important for adequate patient management. Case presentation: We report the atypical onset of T-lineage ALL in a 31-year-old man. The patient was admitted to the emergency room due to lung failure; at that moment, the patient's initial blood count was normal; the chest X-ray radiography showed a massive pleural effusion and a thoracentesis was carried out. Routine investigations performed on the pleural fluid using a new technology system and digitalized cell analysis demonstrated infiltration by immature cells. Therefore, bone marrow aspirate and flow cytometry analyses were performed, leading to the diagnosis of T-lineage ALL. A cord blood transplantation procedure was performed at the first hematological remission following chemotherapy regimens. The patient died of septic shock. Conclusion: The case we reported underlines the usefulness of using automated instruments to identify abnormal lymphoid cells in body fluids. Keywords: pleural effusion, digital morphology, leukemia

Published
2013

24. Long-Term Health Related Quality Of Life and Symptom Burden In Patients With Acute Promyelocytic Leukemia Treated With All-Trans Retinoic Acid (ATRA) and Chemotherapy

Author

Efficace, Fabio, primary, Rambaldi, Alessandro, additional, Di Bona, Eros, additional, Fabbiano, Francesco, additional, Cottone, Francesco, additional, Breccia, Massimo, additional, Avvisati, Giuseppe, additional, Foà, Robin, additional, Morselli, Monica, additional, Cutini, Ilaria, additional, Rossetti, Elena, additional, Leoni, Pietro, additional, Falini, Brunangelo, additional, Romani, Claudio, additional, Di Raimondo, Francesco, additional, Mancini, Valentina, additional, D'Ardia, Stefano, additional, Martinelli, Giovanni, additional, Cassibba, Vincenzo, additional, Finizio, Olimpia, additional, Cascavilla, Nicola, additional, Carella, Angelo Michele, additional, Vignetti, Marco, additional, Mandelli, Franco, additional, and Lo Coco, Francesco, additional

Published
2013
Full Text
View/download PDF

25. A systematic analysis of bone marrow cells by flow cytometry defines a specific phenotypic profile beyond GPI deficiency in paroxysmal nocturnal hemoglobinuria

Author

Mannelli, Francesco, primary, Bencini, Sara, additional, Peruzzi, Benedetta, additional, Cutini, Ilaria, additional, Sanna, Alessandro, additional, Benelli, Matteo, additional, Magi, Alberto, additional, Gianfaldoni, Giacomo, additional, Rotunno, Giada, additional, Carrai, Valentina, additional, Gelli, Anna Maria Grazia, additional, Valle, Veronica, additional, Santini, Valeria, additional, Notaro, Rosario, additional, Luzzatto, Lucio, additional, and Bosi, Alberto, additional

Published
2012
Full Text
View/download PDF

27. Blinatumomab in adult acute lymphoblastic leukemia right now.

Author

Cutini, Ilaria and Bosi, Alberto

Subjects
*LYMPHOBLASTIC leukemia treatment, *ANTINEOPLASTIC agents
Abstract

Blinatumomab for the treatment of relapsed or refractory adult acute lymphoblastic leukemia is a therapeutic option that offers alone an overall response rate of 30% to 40% which means more opportunities for high risk patients to undergo to allogeneic transplant. Encouraging reports on the activity of blinatumomab in R/R Philadelphia chromosomenegative B-cell precursor ALL led to its approval by the US Food and Drug Administration on December 3, 2014 after an accelerated review process. Below there is a brief review of the molecule and its clinical and biological implication since now. [ABSTRACT FROM AUTHOR]

Published
2015

28. A systematic analysis of bone marrow cells by flow cytometry defines a specific phenotypic profile beyond GPI deficiency in paroxysmal nocturnal hemoglobinuria.

Author

Mannelli, Francesco, Bencini, Sara, Peruzzi, Benedetta, Cutini, Ilaria, Sanna, Alessandro, Benelli, Matteo, Magi, Alberto, Gianfaldoni, Giacomo, Rotunno, Giada, Carrai, Valentina, Gelli, Anna Maria Grazia, Valle, Veronica, Santini, Valeria, Notaro, Rosario, Luzzatto, Lucio, and Bosi, Alberto

Published
2013
Full Text
View/download PDF

29. A Multicenter Real-life Prospective Study of Axicabtagene Ciloleucel versus Tisagenlecleucel Toxicity and Outcomes in Large B-cell Lymphomas.

Author

Stella F, Chiappella A, Casadei B, Bramanti S, Ljevar S, Chiusolo P, Di Rocco A, Tisi MC, Carrabba MG, Cutini I, Martino M, Dodero A, Bonifazi F, Santoro A, Sorà F, Botto B, Barbui AM, Russo D, Musso M, Grillo G, Krampera M, Olivieri J, Ladetto M, Cavallo F, Massaia M, Arcaini L, Pennisi M, Zinzani PL, Miceli R, and Corradini P

Subjects
Humans, Male, Female, Middle Aged, Prospective Studies, Aged, Adult, Antigens, CD19 immunology, Antigens, CD19 therapeutic use, Immunotherapy, Adoptive adverse effects, Immunotherapy, Adoptive methods, Treatment Outcome, Receptors, Antigen, T-Cell therapeutic use, Receptors, Antigen, T-Cell immunology, Aged, 80 and over, Lymphoma, Large B-Cell, Diffuse drug therapy, Lymphoma, Large B-Cell, Diffuse immunology, Lymphoma, Large B-Cell, Diffuse mortality, Biological Products adverse effects, Biological Products therapeutic use, Biological Products administration & dosage
Abstract

This real-world prospective observational study across 21 Italian centers (CART-SIE) compares axicabtagene ciloleucel (axi-cel) and tisagenlecleucel (tisa-cel) outcomes in 485 patients with relapsed/refractory large B-cell lymphoma with baseline characteristics matched by stabilized inverse propensity score weighting. Axi-cel versus tisa-cel had higher all-grade cytokine release syndrome (78.6% vs. 89.3%, P = 0.0017) and neurotoxicity (9.9% vs. 32.2%, P < 0.0001) but also superior progression-free survival (PFS) at 1 year (46.5% vs. 34.1%, P = 0.0009). Even among patients who failed bridging therapy, axi-cel PFS was superior to tisa-cel (37.5% vs. 22.7%, P = 0.0059). Differences in overall survival and high-grade immune toxicities were not significant. The CAR-HEMATOTOX score not only predicted hematologic toxicity but also 1-year survival outcomes (51.5% in CAR-HEMATOTOX high vs. 77.2% in CAR-HEMATOTOX low, P < 0.0001). Twenty patients developed second primary malignancies, including two cases of T-cell neoplasms. These findings enable more informed selection of anti-CD19 CAR T-cell therapy, balancing bridging, safety, and efficacy considerations for individual patients. Significance: The findings of this study on 485 patients with relapsed/refractory large B-cell lymphoma treated with commercial axi-cel and tisa-cel indicate axi-cel's superior PFS after propensity score weighting. The predictive utility of CAR-HEMATOTOX in assessing not only toxicity but also outcomes across both CAR T-cell products may guide future risk-stratified management strategies., (©2024 The Authors; Published by the American Association for Cancer Research.)

Published
2024
Full Text
View/download PDF

30. CEBPA -double-mutated acute myeloid leukemia displays a unique phenotypic profile: a reliable screening method and insight into biological features.

Author

Mannelli F, Ponziani V, Bencini S, Bonetti MI, Benelli M, Cutini I, Gianfaldoni G, Scappini B, Pancani F, Piccini M, Rondelli T, Caporale R, Gelli AM, Peruzzi B, Chiarini M, Borlenghi E, Spinelli O, Giupponi D, Zanghì P, Bassan R, Rambaldi A, Rossi G, and Bosi A

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Biomarkers, Tumor, Bone Marrow pathology, CCAAT-Enhancer-Binding Protein-alpha metabolism, Cluster Analysis, Cytogenetic Analysis, DNA Mutational Analysis, Female, Genetic Association Studies, Genotype, Humans, Immunophenotyping, Kaplan-Meier Estimate, Leukemia, Myeloid, Acute mortality, Male, Middle Aged, Prognosis, Reproducibility of Results, Sensitivity and Specificity, Young Adult, CCAAT-Enhancer-Binding Protein-alpha genetics, Leukemia, Myeloid, Acute diagnosis, Leukemia, Myeloid, Acute genetics, Mutation, Phenotype
Abstract

Mutations in CCAAT/enhancer binding protein α ( CEBPA ) occur in 5-10% of cases of acute myeloid leukemia. CEBPA -double-mutated cases usually bear biallelic N- and C-terminal mutations and are associated with a favorable clinical outcome. Identification of CEBPA mutants is challenging because of the variety of mutations, intrinsic characteristics of the gene and technical issues. Several screening methods (fragment-length analysis, gene expression array) have been proposed especially for large-scale clinical use; although efficient, they are limited by specific concerns. We investigated the phenotypic profile of blast and maturing bone marrow cell compartments at diagnosis in 251 cases of acute myeloid leukemia. In this cohort, 16 (6.4%) patients had two CEBPA mutations, whereas ten (4.0%) had a single mutation. First, we highlighted that the CEBPA -double-mutated subset displays recurrent phenotypic abnormalities in all cell compartments. By mutational analysis after cell sorting, we demonstrated that this common phenotypic signature depends on CEBPA -double-mutated multi-lineage involvement. From a multidimensional study of phenotypic data, we developed a classifier including ten core and widely available parameters. The selected markers on blasts (CD34, CD117, CD7, CD15, CD65), neutrophil (SSC, CD64), monocytic (CD14, CD64) and erythroid (CD117) compartments were able to cluster CEBPA -double-mutated cases. In a validation set of 259 AML cases from three independent centers, our classifier showed excellent performance with 100% specificity and 100% sensitivity. We have, therefore, established a reliable screening method, based upon multidimensional analysis of widely available phenotypic parameters. This method provides early results and is suitable for large-scale detection of CEBPA -double-mutated status, allowing gene sequencing to be focused in selected cases., (Copyright© Ferrata Storti Foundation.)

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results