1. Yeast Protein Interactome Topology Provides Framework for Coordinated-Functionality
- Author
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Valente, Andre X. C. N. and Cusick, Michael E.
- Subjects
Quantitative Biology - Molecular Networks ,Condensed Matter - Other Condensed Matter ,Condensed Matter - Statistical Mechanics ,Quantitative Biology - Other Quantitative Biology - Abstract
The architecture of the network of protein-protein physical interactions in Saccharomyces cerevisiae is exposed through the combination of two complementary theoretical network measures, betweenness centrality and `Q-modularity'. The yeast interactome is characterized by well-defined topological modules connected via a small number of inter-module protein interactions. Should such topological inter-module connections turn out to constitute a form of functional coordination between the modules, we speculate that this coordination is occurring typically in a pair-wise fashion, rather than by way of high-degree hub proteins responsible for coordinating multiple modules. The unique non-hub-centric hierarchical organization of the interactome is not reproduced by gene duplication-and-divergence stochastic growth models that disregard global selective pressures., Comment: Final, revised version. 13 pages. Please see Nucleic Acids open access article for higher resolution figures
- Published
- 2005
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