55 results on '"Cury, C."'
Search Results
2. Using indirect methods to constrain symbiotic nitrogen fixation rates: a case study from an Amazonian rain forest
- Author
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Cleveland, Cury C., Houlton, Benjamin Z., Neill, Christopher, Reed, Sasha C., Townsend, Alan R., and Wang, Yingping
- Published
- 2010
- Full Text
- View/download PDF
3. Brainhack: Developing a culture of open, inclusive, community-driven neuroscience
- Author
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Gau, R, Noble, S, Heuer, K, Bottenhorn, KL, Bilgin, IP, Yang, YF, Huntenburg, JM, Bayer, JMM, Bethlehem, RAI, Rhoads, SA, Vogelbacher, C, Borghesani, V, Levitis, E, Wang, HT, Van Den Bossche, S, Kobeleva, X, Legarreta, JH, Guay, S, Atay, SM, Varoquaux, GP, Huijser, DC, Sandström, MS, Herholz, P, Nastase, SA, Badhwar, AP, Dumas, G, Schwab, S, Moia, S, Dayan, M, Bassil, Y, Brooks, PP, Mancini, M, Shine, JM, O'Connor, D, Xie, X, Poggiali, D, Friedrich, P, Heinsfeld, AS, Riedl, L, Toro, R, Caballero-Gaudes, C, Eklund, A, Garner, KG, Nolan, CR, Demeter, DV, Barrios, FA, Merchant, JS, McDevitt, EA, Oostenveld, R, Craddock, RC, Rokem, A, Doyle, A, Ghosh, SS, Nikolaidis, A, Stanley, OW, Uruñuela, E, Anousheh, N, Arnatkeviciute, A, Auzias, G, Bachar, D, Bannier, E, Basanisi, R, Basavaraj, A, Bedini, M, Bellec, P, Benn, RA, Berluti, K, Bollmann, S, Bradley, C, Brown, J, Buchweitz, A, Callahan, P, Chan, MY, Chandio, BQ, Cheng, T, Chopra, S, Chung, AW, Close, TG, Combrisson, E, Cona, G, Constable, RT, Cury, C, Dadi, K, Damasceno, PF, Das, S, De Vico Fallani, F, DeStasio, K, Dickie, EW, Dorfschmidt, L, Duff, EP, DuPre, E, Dziura, S, Esper, NB, Esteban, O, Fadnavis, S, Flandin, G, Flannery, JE, Flournoy, J, Forkel, SJ, Gau, R, Noble, S, Heuer, K, Bottenhorn, KL, Bilgin, IP, Yang, YF, Huntenburg, JM, Bayer, JMM, Bethlehem, RAI, Rhoads, SA, Vogelbacher, C, Borghesani, V, Levitis, E, Wang, HT, Van Den Bossche, S, Kobeleva, X, Legarreta, JH, Guay, S, Atay, SM, Varoquaux, GP, Huijser, DC, Sandström, MS, Herholz, P, Nastase, SA, Badhwar, AP, Dumas, G, Schwab, S, Moia, S, Dayan, M, Bassil, Y, Brooks, PP, Mancini, M, Shine, JM, O'Connor, D, Xie, X, Poggiali, D, Friedrich, P, Heinsfeld, AS, Riedl, L, Toro, R, Caballero-Gaudes, C, Eklund, A, Garner, KG, Nolan, CR, Demeter, DV, Barrios, FA, Merchant, JS, McDevitt, EA, Oostenveld, R, Craddock, RC, Rokem, A, Doyle, A, Ghosh, SS, Nikolaidis, A, Stanley, OW, Uruñuela, E, Anousheh, N, Arnatkeviciute, A, Auzias, G, Bachar, D, Bannier, E, Basanisi, R, Basavaraj, A, Bedini, M, Bellec, P, Benn, RA, Berluti, K, Bollmann, S, Bradley, C, Brown, J, Buchweitz, A, Callahan, P, Chan, MY, Chandio, BQ, Cheng, T, Chopra, S, Chung, AW, Close, TG, Combrisson, E, Cona, G, Constable, RT, Cury, C, Dadi, K, Damasceno, PF, Das, S, De Vico Fallani, F, DeStasio, K, Dickie, EW, Dorfschmidt, L, Duff, EP, DuPre, E, Dziura, S, Esper, NB, Esteban, O, Fadnavis, S, Flandin, G, Flannery, JE, Flournoy, J, and Forkel, SJ
- Published
- 2021
4. Spatiotemporal analysis for detection of pre-symptomatic shape changes in neurodegenerative diseases: Initial application to the GENFI cohort
- Author
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Cury, C. (Claire), Durrleman, S. (Stanley), Cash, D.M. (David M.), Lorenzi, M. (Marco), Nicholas, J.M. (Jennifer M.), Bocchetta, M. (Martina), Swieten, J.C. (John) van, Borroni, B. (Barbara), Galimberti, D. (Daniela), Masellis, M. (Mario), Tartaglia, M.C. (Maria Carmela), Rowe, J.B. (James), Graff, C. (Caroline), Tagliavini, F. (Fabrizio), Frisoni, G.B. (Giovanni B.), Laforce, R. (Robert), Finger, E. (Elizabeth), De Mendonça, A. (Alexandre), Sorbi, S. (Sandro), Ourselin, S. (Sebastien), Rohrer, J.D. (Jonathan D.), Modat, M. (Marc), Andersson, C. (Christin), Archetti, S. (Silvana), Arighi, A. (Andrea), Benussi, L. (Luisa), Black, S. (Sandra), Cosseddu, M. (Maura), Fallstrm, M. (Marie), Ferreira, C. (Carlos), Fenoglio, C. (Chiara), Fox, N. (Nick), Freedman, M. (Morris), Fumagalli, G. (Giorgio), Gazzina, S. (Stefano), Ghidoni, R. (Roberta), Grisoli, M. (Marina), Jelic, V. (Vesna), Jiskoot, L.C. (Lize), Keren, R. (Ron), Lombardi, G. (Gemma), Maruta, C. (Carolina), Meeter, L.H.H. (Lieke), Thornton, A.S. (Andrew), Nacmias, B. (Benedetta), ijerstedt, L. (Linn), Padovani, A. (Alessandro), Panman, J. (Jessica), Pievani, M. (Michela), Polito, C. (Cristina), Premi, E. (Enrico), Prioni, S. (Sara), Rademakers, S. (Suzanne), Redaelli, V. (Veronica), Rogaeva, E. (Ekaterina), Rossi, G. (Giacomina), Rossor, M. (Martin), Scarpini, E. (Elio), Tang-Wai, D. (David), Tartaglia, C. (Carmela), Thonberg, H. (Håkan), Tiraboschi, P. (Pietro), Verdelho, A. (Ana), Warren, J. (Jason), Cury, C. (Claire), Durrleman, S. (Stanley), Cash, D.M. (David M.), Lorenzi, M. (Marco), Nicholas, J.M. (Jennifer M.), Bocchetta, M. (Martina), Swieten, J.C. (John) van, Borroni, B. (Barbara), Galimberti, D. (Daniela), Masellis, M. (Mario), Tartaglia, M.C. (Maria Carmela), Rowe, J.B. (James), Graff, C. (Caroline), Tagliavini, F. (Fabrizio), Frisoni, G.B. (Giovanni B.), Laforce, R. (Robert), Finger, E. (Elizabeth), De Mendonça, A. (Alexandre), Sorbi, S. (Sandro), Ourselin, S. (Sebastien), Rohrer, J.D. (Jonathan D.), Modat, M. (Marc), Andersson, C. (Christin), Archetti, S. (Silvana), Arighi, A. (Andrea), Benussi, L. (Luisa), Black, S. (Sandra), Cosseddu, M. (Maura), Fallstrm, M. (Marie), Ferreira, C. (Carlos), Fenoglio, C. (Chiara), Fox, N. (Nick), Freedman, M. (Morris), Fumagalli, G. (Giorgio), Gazzina, S. (Stefano), Ghidoni, R. (Roberta), Grisoli, M. (Marina), Jelic, V. (Vesna), Jiskoot, L.C. (Lize), Keren, R. (Ron), Lombardi, G. (Gemma), Maruta, C. (Carolina), Meeter, L.H.H. (Lieke), Thornton, A.S. (Andrew), Nacmias, B. (Benedetta), ijerstedt, L. (Linn), Padovani, A. (Alessandro), Panman, J. (Jessica), Pievani, M. (Michela), Polito, C. (Cristina), Premi, E. (Enrico), Prioni, S. (Sara), Rademakers, S. (Suzanne), Redaelli, V. (Veronica), Rogaeva, E. (Ekaterina), Rossi, G. (Giacomina), Rossor, M. (Martin), Scarpini, E. (Elio), Tang-Wai, D. (David), Tartaglia, C. (Carmela), Thonberg, H. (Håkan), Tiraboschi, P. (Pietro), Verdelho, A. (Ana), and Warren, J. (Jason)
- Abstract
Brain atrophy as measured from structural MR images, is one of the primary imaging biomarkers used to track neurodegenerative disease progression. In diseases such as frontotemporal dementia or Alzheimer's disease, atrophy can be observed in key brain structures years before any clinical symptoms are present. Atrophy is most commonly captured as volume change of key structures and the shape changes of these structures are typically not analysed despite being potentially more sensitive than summary volume statistics over the entire structure. In this paper we propose a spatiotemporal analysis pipeline based on Large Diffeomorphic Deformation Metric Mapping (LDDMM) to detect shape changes from volumetric MRI scans. We applied our framework to a cohort of individuals with genetic variants of frontotemporal dementia and healthy controls from the Genetic FTD Initiative (GENFI) study. Our method, take full advantage of the LDDMM framework, and relies on the creation of a population specific average spatiotemporal trajectory of a relevant brain structure of interest, the thalamus in our case. The residuals from each patient data to the average spatiotemporal trajectory are then clustered and studied to assess when presymptomatic mutation carriers differ from healthy control subjects. We found statistical differences in shape in the anterior region of the thalamus at least five years before the mutation carrier subjects develop any clinical symptoms. This region of the thalamus has been shown to be predominantly connected to the frontal lobe, consistent with the pattern of cortical atrophy seen in the disease.
- Published
- 2019
- Full Text
- View/download PDF
5. Edoxaban versus warfarin in patients with atrial fibrillation
- Author
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Robert P. Giugliano, Christian T. Ruff, Eugene Braunwald, Sabina A. Murphy, Stephen D. Wiviott, Jonathan L. Halperin, Albert L. Waldo, Michael D. Ezekowitz, Jeffrey I. Weitz, Jind?ich ?pinar, Witold Ruzyllo, Mikhail Ruda, Yukihiro Koretsune, Joshua Betcher, Minggao Shi, Laura T. Grip, Shirali P. Patel, Indravadan Patel, James J. Hanyok, Michele Mercuri, Elliott M. Antman, Braunwald E, Antman EM, Giugliano RP, Ruff CT, Morin SE, Hoffman EB, Murphy SA, Deenadayalu N, Grip L, Mercuri M, Lanz H, Patel I, Curt V, Duggal A, Hanyok J, Davé J, Morgan D, Choi Y, Shi M, Jin J, Xie J, Crerand W, Kappelhof J, Maxwell W, Skinner M, Patel S, Betcher J, Selicato G, Otto C. Jr, Reissner C, Smith K, Ostroske J, Ron A, Giugliano R, Connolly S, Camm J, Ezekowitz M, Halperin J, Waldo A, Paolasso E, Aylward P, Heidbuchel H, Nicolau JC, Goudev A, Roy D, Weitz J, Corbalán R, Yang Y, Botero R, Bergovec M, Ŝpinar J, Grande P, Hassager C, Voitk J, Huikuri H, Nieminen M, Blanc JJ, LeHeuzey JY, Mitrovic V, Alexopoulos D, Sotomora G, Kiss R, SomaRaju B, Lewis B, Merlini P, Metra M, Koretsune Y, Yamashita T, García Castillo A, Ophuis T, White H, Atar D, Horna M, Babilonia N, Ruzyllo W, Morais J, Dorobantu M, Ruda M, Ostojic M, Duris T, Dalby A, Chung N, Zamorano JL, Juul Möller S, Moccetti T, Chen SA, Sritara P, Oto A, Parkhomenko A, Senior R, Verheugt F, Skene A, Anderson J, Bauer K, Easton JD, Goto S, Wiviott S, Lowe C, Awtry E, Berger CJ, Croce K, Desai A, Gelfand E, Goessling W, Greenberger NJ, Ho C, Leeman DE, Link MS, Norden AD, Pande A, Rost N, Ruberg F, Silverman S, Singhal A, Vita JA, Vogelmann O, Gonzalez C, Ahuad Guerrero R, Rodriguez M, Albisu J, Rosales E, Allall O, Reguero M, Alvarez C, Garcia M, Ameriso S, Ameriso P, Amuchastegui M, Caceres M, Beloscar J, Petrucci J, Berli M, Budassi N, Valle M, Bustamante Labarta G, Saravia M, Caccavo A, Fracaro V, Cartasegna L, Novas V, Caruso O, Zarandon RS, Colombo H, Morandini M, Cuello J, Rosell M, Cuneo C, Bocanera M, D'Amico A, Cendali G, Dran R, Moreno V, Estol C, Davolos M, Facello A, Facello M, Falu E, Iriarte M, Femenia F, Arrieta M, Fuselli J, Zanotti A, Gant Lopez J, Meiller F, Garcia Duran R, Perlo D, Garrido M, Ceirano C, Giacomi G, Eden M, Giannaula R, Huerta M, Goicoechea R, von Wulffen M, Hominal M, Bianchini M, Jure H, Jure D, Kevorkian R, Monaco F, Lanternier G, Belcuore M, Liniado G, Iglesias M, Litvak B, Nigro A, Llanos J, Vignau S, Lorente C, Shatsky K, Lotti J, Raimondi G, Mackinnon I, Carne M, Manuale O, Calderon M, Marino J, Funes I, Muntaner J, Gandur H, Nul D, Verdini E, Piskorz D, Tommasi A, Povedano G, Casares E, Pozzer D, Fernandez E, Prado A, Venturini C, Ramos H, Navarrete S, Alvarez M, Sanchez A, Bowen L, Sanjurjo M, Codutti O, Saravia Toledo S, Formoso I, Schmidberg J, Goloboulicz A, Schygiel P, Buzzetti C, Severino P, Morara P, Sosa Liprandi M, Teves M, Vico M, Morell Y, Anderson C, Paraskevaidis T, Arstall M, Hoffmann B, Colquhoun D, Price Smith S, Crimmins D, Slattery A, Dart A, Kay S, Davis S, Silver G, Flecknoe Brown S, Roberts J, Gates P, Jones S, Lehman R, Morrison H, McKeirnan M, Li J, Paul V, Batta C, Purnell P, Perrett L, Szto G, O'Shea V, Capiau L, Banaeian F, De Bleecker J, de Koning K, De Tollenaere M, De Bruyne L, Desfontaines P, Tincani G, Meeusen K, Herzet J, Malmendier D, Mairesse G, Raepers M, Parqué J, Clinckemaille N, Scavée C, Huyberechts D, Stockman D, Jacobs C, Vandekerckhove Y, Derycker K, Vanwelden J, van Welden J, Vervoort G, Mestdagh I, Vrolix M, Beerts C, Wollaert B, Denie D, Amato Vincenzo de Paola A, Coutinho E, Andrade Lotufo P, de Melo RF, Atie J, Motta C, Augusto Alves da Costa F, Ferraz RF, Bertolim Precoma D, Sehnem E, Botelho R, Cunha S, Brondani R, Fleck N, Chaves Junior H, Silva J, Costantini C, Barroso D, De Patta M, Pereira V, Duda N, Laimer R, Dutra O, Morgado S, Faustino Saporito W, Seroqui M, Ferreira L, Araújo E, Finimundi H, Daitz C, Gagliardi R, Pereira G, Gomes M, Gomes A, Guimarães A, Ninho L, Jaeger C, Pereira L, Jorge J, Cury C, Kaiser S, Almeida A, Kalil C, Radaelli G, Kunz Sebba Barroso de Souza W, Morales K, Leaes P, Luiz RO, Pimenta Almeida J, Gozalo A, Reis G, Avellar K, Reis Katz Weiand L, Leipelt J, Rocha J, Barros R, Rodrigues L, Rocha MR, Rodrigues A, Rodrigues D, Rossi dos Santos F, Pagnan LG, Sampaio R, do Val R, Saraiva J, Vicente C, Simoes M, Carraro A, Sobral Filho D, Lustosa E, Villas Boas F, Almeida M, Zimmermann S, Zimmermann EB, Chompalova B, Parishev G, Denchev S, Milcheva N, Donova T, Gergova V, Georgiev B, Kostova E, Kinova E, Hergeldjieva V, Kamenova P, Manolova A, Vasilev I, Mihov A, Miteva B, Mincheva V, Stoyanovski V, Nikolov F, Vasilev D, Pencheva G, Kostov K, Petranov S, Milusheva T, Popov A, Staneva A, Momchilova Lozeva D, Todorov G, Nyagina M, Tumbev H, Tumbeva D, Tzekova M, Kitova M, Manoylov E, Archibald J, Antle S, Bhargava R, Stafford C, Bose S, Hundseth M, Cha J, Otis J, Chehayeb R, Lepage C, Chilvers M, Vansickle L, Cleveland D, Valley S, Constance C, Gauthier M, Costi P, Masson C, Coutu B, Denis I, du Preez M, Kubanska A, Dufresne M, Krider J, Eikelboom J, Zondag M, Fortin C, Viau C, Green M, Houbraken D, Hatheway R, Mabee J, Heath J, Scott L, Ho K, Ho V, Hoag G, Standring R, Huynh T, Perkins L, Kouz S, Roy M, Labonte R, Dewar C, Lainesse A, St Germain L, Lam S, Lam H, Lichtenstein T, Roberts P, Luton R, Douglas S, Ma P, Seib M, MacCallum C, Matthews J, Malette P, Vaillancourt T, Maranda C, Studenikow E, Mawji A, Morely A, Morrison D, Roth M, Mucha M, Najarali A, Lamoureux U, Nicholson R, O'Hara G, Banville P, O'Mahony W, Bolton R, Parkash R, Carroll L, Pesant Y, Sardin V, Polasek P, Turri L, Qureshi A, Nethercott C, Ricci J, Bozek B, Rupka D, Marchand C, Shu D, Silverio G, St Hilaire R, Morissette A, Sussman J, Kailey P, Syan G, Bobbie C, Talajic M, David D, Talbot P, Tremblay M, Teitelbaum I, Teitelbaum J, Velthuysen G, Giesbrecht L, Wahby R, Morley A, Wharton S, Caterini T, Woodford T, Balboa W, Matus LR, Bugueño C, Mondaca PM, Cobos J, Obreque C, Corbalan R, Parada A, Florenzano F, Diaz PA, Lopetegui M, Rebolledo C, Manriquez L, Silva LM, Martinez D, Llamas RR, Opazo M, Pérez MC, Pincetti C, Carrasco GT, Potthoff S, Staub JZ, Campisto Y, Stockins B, Lara CL, Yovaniniz P, Azua MG, Bai F, Xu GL, Chen JZ, Xie XD, Chen XP, Zhang X, Dong YG, Feng C, Fu GS, Zhang P, Hong K, You ZG, Hong L, Qiu Y, Jiang XJ, Qu Z, Li L, Liu H, Li TF, Kong YQ, Li WM, Liu B, Li ZQ, Liu Y, Liao DN, Gu XJ, Liu L, Lu ZH, Ma SM, Yang ZY, Wang DM, Qi SY, Wang GP, Shi XJ, Wei M, Huang D, Wu SL, Li YE, Xu JH, Gu JY, Xu YM, Liang YZ, Yang K, Li AY, Yang YJ, Zheng X, Zheng Y, Gao M, Yin YH, Xu YP, Yu B, Li LL, Yuan ZY, Qiang H, Zhang HQ, Lin YN, Zhang Z, Kang H, Zhao RP, Han RJ, Zhao XL, Wang JQ, Zheng ZQ, Li BG, Zhou SX, Zhang YL, Accini J, Accini M, Cano N, Pineda LL, Delgado Restrepo J, Arroyave C, Fernández Ruiz R, Diaz IA, Hernandez H, Delgado P, Jaramillo Muñoz C, Builes A, Manzur F, Rodriguez ER, Moncada Corredor M, Giraldo DL, Orozco Linares L, Fonseca J, Quintero A, Gonzales C, Sanchez Vallejo G, Mejia IP, Bagatin J, Carevic V, Car S, Jeric M, Ciglenecki N, Tusek S, Ferri Certic J, Romic I, Francetic I, Ausperger KM, Jelic V, Jurinjak SJ, Knezevic A, Buksa B, Samardzic P, Lukenda KC, Steiner R, Kirner D, Sutalo K, Bakliza Z, Vrazic H, Lucijanic T, Bar M, Brodova P, Berka L, Kunkelova V, Brtko M, Burianova H, Cermak O, Elbl L, Ferkl R, Florian J, Francek L, Golan L, Gregor P, Honkova M, Hubac J, Jandik J, Jarkovsky P, Jelinek Z, Jerabek O, Jirmar R, Kobza R, Kochrt M, Kostkova G, Kosek Z, Kovar P, Kuchar R, Kvasnicka J, Ludka O, Machova V, Krocova E, Melichar M, Nechanicky R, Olsr J, Peterka K, Petrova I, Havlova I, Pisova J, Podrazil P, Jirsova E, Reichert P, Slaby J, Spacek R, Spinar J, Labrova R, Vodnansky P, Samkova D, Zidkova E, Dodt K, Christensen H, Christensen L, Loof A, Ibsen H, Madsen H, Iversen H, Veng Olsen T, Nielsen H, Olsen R, Overgaard K, Petrovic V, Raymond I, Raae D, Sand N, Svenningsen A, Torp Pedersen C, Jakobsen U, Wiggers H, Serup Hansen K, Kaik J, Stern A, Kolk R, Laane E, Rivis L, Paumets M, Laheäär M, Rosenthal A, Rajasalu R, Vahula V, Ratnik E, Kaarleenkaski S, Hussi E, Valpas S, Jäkälä P, Lappalainen T, Mäenpää A, Viitaniemi J, Nyman K, Sankari T, Rasi H, Salminen O, Virtanen V, Nappila H, Le Heuzey J, Agraou B, El Jarroudi F, Amarenco P, Boursin P, Babuty D, Boyer M, Belhassane A, Berbari H, Blanc J, Dias P, Coisne D, Berger N, Decoulx E, El Jarroudi M, Dinanian S, Arfaoui M, Hermida J, Deruche E, Kacet S, Corbut S, Poulard J, Leparree S, Roudaut R, Duprat C, Al Zoebi A, Wurow A, Bernhardt P, Dichristin U, Berrouschot J, Vierbeck S, Beyer Westendorf J, Sehr B, Bouzo M, Schnelzer P, Braun R, Ladenburger K, Buhr M, Weihrauch D, Contzen C, Kara M, Daut W, Ayasse D, Degtyareva E, Kranz P, Drescher T, Herfurth B, Faghih M, Forck Boedeker K, Schneider K, Fuchs R, Manuela W, Grigat C, Otto A, Hartmann A, Peitz M, Heuer H, Dieckheuer U, Hoffmann U, Dorn S, Hoffmann S, Schuppe M, Horacek T, Fink P, Junggeburth J, Schmid S, Jungmair W, Schoen B, Kleinecke Pohl U, Meusel P, Koenig H, Bauch F, Lohrbaecher Kozak I, Grosse B, Lueders S, Venneklaas U, Luttermann M, Wulf M, Maus O, Hoefer K, Meissner G, Braemer U, Meyer Pannwitt U, Frahm E, Vogt S, Muegge A, Barbera S, Mueller Glamann M, Raddatz K, Piechatzek R, Lewinsky D, Pohl W, Proskynitopoulos N, Kuhlmann M, Rack K, Pilipenko H, Rinke A, Kühlenborg A, Schaefer A, Szymanowski N, Schellong S, Frommhold R, Schenkenberger I, Finsterbusch T, Dreykluft K, Schiewe C, Schmidt A, Schmidt M, Schreckenberg A, Hellmers J, Seibert H, Gold G, Sohn H, Baylacher M, Spitzer S, Bonin K, Stoehring 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Pazier P, Riofrio K, Braun D, Robinson J, Cherrico M, Roehll W, Hollihan P, Rosado, Barnhorst M, Rosado J, Bamhorst M, Rosen R, Martin C, Ross S, Freeman R, Ruoff G, Nelson T, Sacco J, Ball E, Samal A, Schomburg J, Sandberg J, Lafave J, Savin V, Clifton R, Schaefer S, Fekete A, Schneider R, Schneider W, Schulman D, Mercer S, Seals A, Ullig T, Holt A, Seide H, Mather N, Shah G, Witt P, Shalaby A, Seese M, Shanes J, Fleets J, Shaoulian E, Hren A, Sheikh K, Hengerer T, Shih H, Browning J, Shoukfeh M, Stephenson L, Siler T, Champagne M, Simpson P, Meyer R, Singh N, Turner K, Singh V, Nelson M, Skierka R, Hughes B, Keene R, Smith R, Hodnett P, Spangenthal S, Thomason L, Sperling M, Vasquez E, Spivack E, McCartney P, Staniloae C, Liu M, Steljes A, Cox C, Struble R, Vittitow T, Suresh D, Frost J, Swerchowsky V, Freemyer D, Szulawski I, Herwehe S, Tahirkheli N, Springer K, Takata T, Bruton T, Talano J, Leo L, Tami L, Corchado D, Tatarko M, Swauger M, Tawney K, Dastoli K, Teague S, Young K, Tee H, Mitchell T, Teixeira J, Southam D, Torres M, Tucker P, Salas L, Updegrove J, Hanna K, Val Mejias J, Harrelson KG, Vemireddy D, Cardoza T, Verma S, Parsons T, Vicari R, Warren K, Vijay N, Washam M, Vossler M, Kilcup S, Walsh R, Renaud K, Ward S, Locklear T, Waxman F, Sanchez G, Weiss R, St Laurent B, Westcott J, Williams D, Gibson C, Williams R, Dowling C, Willis J, VonGerichten S, Wood K, Capasso Gulve E, Worley S, Pointer S, Yarows S, Sheehan T, Yasin M, Yi J, Dongas B, Yousuf K, Zakhary B, Curtis S, Zeig S, Mason T, Zellner C, Harden M, Roper E, Waseem M, Grammer M., PERRONE FILARDI, PASQUALE, Cardiovascular Division (SZG), Brigham and Women's Hospital [Boston], Mount Sinai Medical Center, Icahn School of Medicine at Mount Sinai [New York] (MSSM), University Hospitals Case Medical Center (CLEVELAND - UHCMC), University Hospitals Case Medical Center, Jefferson Medical College (JMC), Thomas Jefferson University Hospitals, Thrombosis and Atherosclerosis Research Institute (TARI), McMaster University [Hamilton, Ontario], University Hospital Brno, Institute of Cardiology (WARSAW - Cardiology), Institute of Cardiology, Cardiology Research Center (MOSCOU - CRC), Cardiology Research Center, National Hopital Organization (OSAKA - NHO), Osaka National Hospital, Université de Brest (UBO), Centre d'Investigation Clinique (CIC - Brest), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Graduate School, Endocrinology, ACS - Amsterdam Cardiovascular Sciences, Cardiology, Nursing, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, General Internal Medicine, Giugliano, Rp, Ruff, Ct, Braunwald, E, Murphy, Sa, Wiviott, Sd, Halperin, Jl, Waldo, Al, Ezekowitz, Md, Weitz, Ji, Špinar, J, Ruzyllo, W, Ruda, M, Koretsune, Y, Betcher, J, Shi, M, Grip, Lt, Patel, Sp, Patel, I, Hanyok, Jj, Mercuri, M, Antman, Em, Comi, Giancarlo, ENGAGE AF TIMI 48, Investigators, Robert P., Giugliano, Christian T., Ruff, Eugene, Braunwald, Sabina A., Murphy, Stephen D., Wiviott, Jonathan L., Halperin, Albert L., Waldo, Michael D., Ezekowitz, Jeffrey I., Weitz, Jind?ich, ?pinar, Witold, Ruzyllo, Mikhail, Ruda, Yukihiro, Koretsune, Joshua, Betcher, Minggao, Shi, Laura T., Grip, Shirali P., Patel, Indravadan, Patel, James J., Hanyok, Michele, Mercuri, Elliott M., Antman, Morin, Se, Hoffman, Eb, Deenadayalu, N, Grip, L, Lanz, H, Curt, V, Duggal, A, Hanyok, J, Davé, J, Morgan, D, Choi, Y, Jin, J, Xie, J, Crerand, W, Kappelhof, J, Maxwell, W, Skinner, M, Patel, S, Selicato, G, Otto C., Jr, Reissner, C, Smith, K, Ostroske, J, Ron, A, Giugliano, R, Connolly, S, Camm, J, Ezekowitz, M, Halperin, J, Waldo, A, Paolasso, E, Aylward, P, Heidbuchel, H, Nicolau, Jc, Goudev, A, Roy, D, Weitz, J, Corbalán, R, Yang, Y, Botero, R, Bergovec, M, Ŝpinar, J, Grande, P, Hassager, C, Voitk, J, Huikuri, H, Nieminen, M, Blanc, Jj, Leheuzey, Jy, Mitrovic, V, Alexopoulos, D, Sotomora, G, Kiss, R, Somaraju, B, Lewis, B, Merlini, P, Metra, M, Yamashita, T, García 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Friedlander, I, Gaffney, M, Jones, J, Garb, J, Miranda, J, George, F, Valentine, H, Gerber, J, Hinchion, N, Gillespie, E, Keane Richmond, P, Gogia, H, Ewing, B, Goldscher, D, Latteri, J, Goldstein, M, Gowda, S, Rafala, E, Graham, S, Bonora, M, Griffin, S, Aull, L, Griffin, J, Goodman, V, Grossman, C, Davis, A, Grove, D, Mabe, K, Guarino, J, Gabela, W, Guarnieri, T, Guerrero, Foster, B, Guthrie, R, Felsman, D, Gvora, T, Mclean, R, Hack, T, Morelli, L, Hamroff, G, Bentivenga, L, Han, M, Cavanna, L, Harris, J, Bobade, M, Hearne, S, Krater, C, Heiman, M, Dandekar, U, Shah, D, Henderson, D, Millard, D, Henry, S, Harkins, V, Hermany, P, Batchell, K, Herrod, J, Miranda, D, Herson, S, Carey, G, Hinchman, D, Vieira, P, Hippert, R, Dutter, S, Hoekstra, J, Homan, J, Homayouni, A, Horton, K, Sloss, D, Hotchkiss, D, Turner, N, Houchin, V, Howard, V, Hays, D, Howard, L, Craft, D, Huang, P, Truva, C, Hunter, J, Battistelli, E, Hurst, P, Garza, M, Hussain, M, Tambawala, M, Ison, R, Butcher, S, Jardula, M, Andresen, T, Johnson, F, Phillips, T, Jones, R, Hughett, G, Jovin, I, Nichols, M, Judson, P, Royes, A, Kahn, B, Coombs, V, Kai, W, Dugal, J, Kandath, D, Kostedt, G, Kaplan, K, Cook, S, Kapoor, A, Ruggiero, M, Karunaratne, H, Behm, K, Kastelic, R, Davis, C, Keller, R, Keller, J, Kerkering, M, Bartholomaus, D, Kersh, R, Buhler, A, Kesselbrenner, M, Dicorcia, L, Khan, B, Binns, M, Khan, M, Khan, G, Kindman, L, Averett, P, Korpas, D, Godfrey, C, Kotha, P, Sanchez, E, Kozlowski, J, Watts, S, Krichmar, P, Marquez, D, Laliotis, A, Jauregui, V, Lambert, C, Coyle, G, Landau, C, Ferguson, D, Lang, J, Simmons, T, Langevin, E, Faucett, S, Ledbetter, L, Royse, H, Lentz, M, Smith, D, Lesser, M, Hartley, L, Lewis, D, Bonds, C, Lillestol, M, Miller, D, Ling, L, Murphy, R, Littlefield, R, Wofford, E, Lomnitz, D, Lone, B, Davids, M, Looby, R, Ault, S, Lui, H, Wright, H, Lurie, M, Edelstein, J, Macomber, J, Bush, D, Magee, A, Doctor, A, Mainigi, S, Lisiecki, B, Makam, S, Casas, R, Mandviwala, M, Marar, I, Rabadi Marar, D, Marenberg, M, Bedenko, E, Massin, E, Hicks, T, Mccartney, M, Stubbs, L, Mcgarvey, J, Schwarz, L, Mcguire, K, Mckenzie, M, Rodkey, K, Mcknight, T, Paul, J, Mclaurin, B, Lack, A, Mega, J, Marti, J, Meholick, A, Skinner, J, Mehrle, A, Wall, J, Mendelson, R, Cervellione, K, Mercado, A, Cajulis, C, Michlin, B, Romero Colon, J, Milas, J, Sanders, D, Miller, R, Sanchez, S, Miller, S, Gryczan, J, Mody, F, Strugatsky, S, Moran, J, Garner, S, Morledge, J, Bowman, B, Mouhaffel, A, Parrott, N, Mounsey, P, Schuler, C, Mowdy, M, Todd, S, Mullen, P, Raziano, S, Murphy, A, Oehmann, V, Nadar, V, Parker, A, Naidu, J, West, M, Nallasivan, M, Goza, J, Nguyen, T, Nomanee, S, Nielsen, R, Wilmot, M, Oberoi, M, Thakkar, N, Oppenheimer, K, Mccormick, J, Orchard, R, Garcia, L, Osborne, J, Gonzalez, M, Oza, S, Joseph, L, Patnam, S, Dennison, K, Pavon, H, Gorry, N, Pearlstein, R, Montayne, S, Pentz, W, Duncan, D, Peters, P, Chacon, L, Petruzziello, F, Morlando, F, Pettis, K, Brown, F, Pezzella, S, Kirk, D, Poulathas, A, Cush, S, Pratt, R, Neeper, L, Pribble, A, Lowe, K, Pudi, K, Sham, L, Pugeda, J, Ebert, J, Quadrel, M, Rafla, E, Quinlan, E, Reed, C, Quinn, J, Hemmen, C, Rama, P, Domingo, D, Redondo, V, Wroblewski, J, Renzi, M, Stanley, E, Richwine, R, Pazier, P, Riofrio, K, Braun, D, Robinson, J, Cherrico, M, Roehll, W, Hollihan, P, Rosado, Barnhorst, M, Rosado, J, Bamhorst, M, Rosen, R, Martin, C, Ross, S, Freeman, R, Ruoff, G, Nelson, T, Sacco, J, Ball, E, Samal, A, Schomburg, J, Sandberg, J, Lafave, J, Savin, V, Clifton, R, Schaefer, S, Fekete, A, Schneider, R, Schneider, W, Schulman, D, Mercer, S, Seals, A, Ullig, T, Holt, A, Seide, H, Mather, N, Shah, G, Witt, P, Shalaby, A, Seese, M, Shanes, J, Fleets, J, Shaoulian, E, Hren, A, Sheikh, K, Hengerer, T, Shih, H, Browning, J, Shoukfeh, M, Stephenson, L, Siler, T, Champagne, M, Simpson, P, Meyer, R, Singh, N, Turner, K, Singh, V, Nelson, M, Skierka, R, Hughes, B, Keene, R, Smith, R, Hodnett, P, Spangenthal, S, 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Grammer, M.
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Male ,Pyridines ,[SDV]Life Sciences [q-bio] ,Embolism ,Kaplan-Meier Estimate ,030204 cardiovascular system & hematology ,chemistry.chemical_compound ,0302 clinical medicine ,Edoxaban ,Atrial Fibrillation ,MESH: Double-Blind Method ,030212 general & internal medicine ,MESH: Warfarin ,Stroke ,MESH: Aged ,MESH: Middle Aged ,Cardiovascular diseases [NCEBP 14] ,Hazard ratio ,General Medicine ,MESH: Follow-Up Studies ,Middle Aged ,3. Good health ,MESH: Atrial Fibrillation ,Cardiovascular Diseases ,Anesthesia ,Cardiology ,Female ,Adult ,Aged ,Anticoagulants ,Double-Blind Method ,Follow-Up Studies ,Hemorrhage ,Humans ,Thiazoles ,Warfarin ,MESH: Hemorrhage ,Andexanet alfa ,medicine.drug ,medicine.medical_specialty ,MESH: Enoxaparin ,MESH: Anticoagulants ,MESH: Stroke ,Dabigatran ,03 medical and health sciences ,Internal medicine ,medicine ,MESH: Kaplan-Meier Estimate ,Rivaroxaban ,MESH: Humans ,business.industry ,MESH: Cardiovascular Diseases ,MESH: Adult ,medicine.disease ,Confidence interval ,MESH: Male ,chemistry ,business ,MESH: Female ,MESH: Embolism - Abstract
Contains fulltext : 125374.pdf (Publisher’s version ) (Open Access) BACKGROUND: Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. METHODS: We conducted a randomized, double-blind, double-dummy trial comparing two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high-risk atrial fibrillation (median follow-up, 2.8 years). The primary efficacy end point was stroke or systemic embolism. Each edoxaban regimen was tested for noninferiority to warfarin during the treatment period. The principal safety end point was major bleeding. RESULTS: The annualized rate of the primary end point during treatment was 1.50% with warfarin (median time in the therapeutic range, 68.4%), as compared with 1.18% with high-dose edoxaban (hazard ratio, 0.79; 97.5% confidence interval [CI], 0.63 to 0.99; P
- Published
- 2013
6. Spatiotemporal analysis for detection of pre-symptomatic shape changes in neurodegenerative diseases: Initial application to the GENFI cohort
- Author
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Cury, C, Durrleman, S, Cash, DM, Lorenzi, M, Nicholas, JM, Bocchetta, M, van Swieten, J.C., Borroni, B, Galimberti, D, Masellis, M, Tartaglia, MC, Rowe, JB, Graff, C, Tagliavini, F, Frisoni, GB, Laforce, R, Jr, Finger, E, De Mendonca, A, Sorbi, S, Ourselin, S, Rohrer, JD, Modat, M, Cury, C, Durrleman, S, Cash, DM, Lorenzi, M, Nicholas, JM, Bocchetta, M, van Swieten, J.C., Borroni, B, Galimberti, D, Masellis, M, Tartaglia, MC, Rowe, JB, Graff, C, Tagliavini, F, Frisoni, GB, Laforce, R, Jr, Finger, E, De Mendonca, A, Sorbi, S, Ourselin, S, Rohrer, JD, and Modat, M
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- 2018
7. Impact of Spontaneous Extracranial Bleeding Events on Health State Utility in Patients with Atrial Fibrillation: Results from the ENGAGE AF‐TIMI 48 Trial
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Senior, R., Paul, J., McKnight, T., Formoso, I., Saravia Toledo, S., Codutti, O., Sanjurjo, M., Bowen, L., Sanchez, A., Alvarez, M., Rodriguez, M., Navarrete, S., Ramos, H., Venturini, C., Prado, A., Fernandez, E., Pozzer, D., Casares, E., Povedano, G., Tommasi, A., Piskorz, D., Verdini, E., Nul, D., Gandur, H., Muntaner, J., Funes, I., Marino, J., Calderon, M., Manuale, O., Carne, M., Mackinnon, I., Raimondi, G., Lotti, J., Shatsky, K., Rodkey, K., Lorente, C., Vignau, S., Llanos, J., Nigro, A., Litvak, B., Iglesias, M., Liniado, G., Belcuore, M., Lanternier, G., Monaco, F., Kevorkian, R., Jure, D., Jure, H., Bianchini, M., Avery, D., Hominal, M., von Wulffen, M., McKenzie, M., Miranda, J., Wright, L., Pye, M., Flint, L., Newby, D., Andrews, A., Goicoechea, R., Huerta, M., Giannaula, R., Eden, M., Giacomi, G., Ceirano, C., Garrido, M., Perlo, D., Garcia Duran, R., Meiller, F., Gant Lopez, J., Zanotti, A., Fuselli, J., Arrieta, M., Femenia, F., Falu, E., Facello, M., Facello, A., Murdoch, D., Helliwell, L., More, R., Isted, C., Maxwell, T., Jones, D., Marazzi, P., McGhee, C., MacLeod, M., Ebano, P., MacCallum, P., Davolos, M., Estol, C., Moreno, V., Dran, R., Cendali, G., D'Amico, A., Bocanera, M., Cuneo, C., Rosell, M., Cuello, J., Morandini, M., Colombo, H., Brown, R., Saa Zarandon, R., Caruso, O., Novas, V., Cartasegna, L., Fracaro, V., Caccavo, A., Saravia, M., Bustamante Labarta, G., Valle, M., Budassi, N., Lip, G., Finlayson, M., Linker, N., McGuire, K., Atkinson, C., Lindsay, S., Ramasamy, V., Lie, F., Dickinson, D., Douglas, H., D'Costa, D., Wilmott, R., Cohen, A., Duff, J., Choy, A., Davies, D., Chapman, O., Dougal, K., Camm, J., Price, R., Blagden, M., Schwarz, L., McGarvey, J., Stubbs, L., McCartney, M., Hicks, T., Massin, E., Bedenko, E., Marenberg, M., Rabadi-Marar, D., Dunn, S., Beeton, I., Smith, S., Aggarwal, R., Marar, I., Hernandez, S., Berli, M., Petrucci, J., Beloscar, J., Caceres, M., Amuchastegui, M., Ameriso, P., Ameriso, S., Garcia, M., Alvarez, C., Reguero, M., Allall, O., Rosales, E., Albisu, J., Ahuad Guerrero, R., Gonzalez, C., Vogelmann, O., Magnuson, Elizabeth A., Cohen, David J., Giugliano, Robert P., Mandviwala, M., Casas, R., Makam, S., Lisiecki, B., Mainigi, S., Doctor, A., Magee, A., Bush, D., Macomber, J., Edelstein, J., Lurie, M., Wright, H., Lui, H., Ault, S., Looby, R., Davids, M., Lone, B., Shah, D., Lomnitz, D., Wofford, E., Littlefield, R., Murphy, R., Ling, L., Miller, D., Lillestol, M., Bonds, C., Lewis, D., Hartley, L., Lesser, M., Smith, D., Lentz, M., Royse, H., Ledbetter, L., Faucett, S., Langevin, E., Simmons, T., Lang, J., Ferguson, D., Landau, C., Coyle, G. Stagi, Lambert, C., Jauregui, V., Laliotis, A., Marquez, D., Krichmar, P., Watts, S., Kozlowski, J., Sanchez, E., Kotha, P., Godfrey, C., Korpas, D., Averett, P., Kindman, L., Khan, G., Khan, M., Binns, M., Khan, B., DiCorcia, L., Kesselbrenner, M., Buhler, A., Kersh, R., Bartholomaus, D., Kerkering, M., Keller, J., Keller, R., Davis, C., Kastelic, R., Behm, K., Karunaratne, H., Ruggiero, M., Kapoor, A., Cook, S., Kaplan, K., Kostedt, G., Kandath, D., Dugal, J., Kai, W., Coombs, V., Kahn, B., Royes, A., Judson, P., Nichols, M., Jovin, I., Hughett, G., Jones, R., Phillips, T., Johnson, F., Andresen, T., Jardula, M., Butcher, S., Ison, R., Tambawala, M., Hussain, M., Garza, M., Hurst, P., Battistelli, E., Hunter, J., Truva, C., Huang, P., Craft, D., Howard, L., Hays, D., Howard, V., Adams, K., Houchin, V., Turner, N., Hotchkiss, D., Sloss, D., Horton, K., Homayouni, A., Homan, J., Young, C., Hoekstra, J., Dutter, S., Hippert, R., Vieira, P., Hinchman, D., Carey, G., Herson, S., Miranda, D., Herrod, J., Batchell, K., Hermany, P., Harkins, V., Henry, S., Millard, D., Henderson, D., Dandekar, U., Heiman, M., Krater, C., Hearne, S., Bobade, M., Harris, J., Cavanna, L., Han, M., Bentivenga, L., Hamroff, G., Morelli, L., Hack, T., McLean, R., Gvora, T., Felsman, D., Guthrie, R., Foster, B., Guerrero, Guerrero, Fisher, M., Guarnieri, T., Gabela, W., Guarino, J., Mabe, K., Grove, D., Davis, A., Grossman, C., Goodman, V., Griffin, J., Aull, L., Griffin, S., Bonora, M., Graham, S., Rafala, E., Gowda, S., Goldstein, M., Latteri, J., Goldscher, D., Ewing, B., Gogia, H., Keane-Richmond, P., Gillespie, E., Hinchion, N., Gerber, J., Valentine, H., George, F., Garb, J., Jones, J., Gaffney, M., Smith, K., Friedlander, I., Morales, C., French, W., Gentry, P., Franco, M., Thrope, C., Frais, M., Solis, A., Forman, S., Slayton, C., Flores, E., Donahue, S., Fishbein, G., Drew, B., Fischell, T., Lim, G., Finkelstein, S., Shriver, D., Finkel, M., Calvo, M., Fialkow, J., Prior, J., Felten, 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L., Zhou, S. X., Li, B. G., Zheng, Z. Q., Wang, J. Q., Zhao, X. L., Han, R. J., Zhao, R. P., Kang, H., Zhang, Z., Lin, Y. N., Zhang, H. Q., Qiang, H., Yuan, Z. Y., Li, L. L., Yu, B., Xu, Y. P., Yin, Y. H., Gao, M., Zheng, Y., Zheng, X., Yang, Y. J., Li, A. Y., Yang, K., Liang, Y. Z., Xu, Y. M., Gu, J. Y., Xu, J. H., Li, Y. E., Wu, S. L., Huang, D., Wei, M., Shi, X. J., Wang, G. P., Qi, S. Y., Wang, D. M., Yang, Z. Y., Ma, S. M., Lu, Z. H., Liu, L., Gu, X. J., Liao, D. N., Liu, Y., Li, Z. Q., Liu, B., Li, W. M., Kong, Y. Q., Li, T. F., Liu, H., Li, L., Qu, Z., Jiang, X. J., Qiu, Y., Hong, L., You, Z. G., Hong, K., Zhang, P., Fu, G. S., Feng, C., Dong, Y. G., Zhang, X., Chen, X. P., Xie, X. D., Chen, J. Z., Xu, G. 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Burger, Zimmermann, S., Almeida, M., Boas, F. Villas, Lustosa, E., Sobral Filho, D., Carraro, A., Simoes, M., Vicente, C., Saraiva, J., do Val, R., Sampaio, R., Pagnan, L. Goncalves, dos Santos, F. Rossi, Rodrigues, D., Rodrigues, A., Rocha, M. Rubia, Rodrigues, L., Barros, R., Rocha, J., Leipelt, J., Katz Weiand, L. Reis, Avellar, K., Reis, G., Gozalo, A., Almeida, J. Pimenta, Luiz, R. Osorio, Leaes, P., Morales, K., Sebba Barroso de Souza, W. Kunz, Radaelli, G., Kalil, C., Almeida, A., Kaiser, S., Cury, C., Jorge, J., Pereira, L., Jaeger, C., Ninho, L., Guimaraes, A., Gomes, A., Gomes, M., Pereira, G., Gagliardi, R., Daitz, C., Finimundi, H., Araujo, E., Ferreira, L., Seroqui, M., Saporito, W. Faustino, Morgado, S., Dutra, O., Laimer, R., Duda, N., Pereira, V., De Patta, M., Barroso, D., Costantini, C., Silva, J., Chaves Junior, H., Fleck, N., Brondani, R., Cunha, S., Botelho, R., Sehnem, E., Precoma, D. Bertolim, Ferraz, R. Franchin, Alves da Costa, F. Augusto, Motta, C., Atie, J., de Melo, R. Ferreira, Lotufo, P. Andrade, Coutinho, E., Vincenzo de Paola, A. Amato, Denie, D., Wollaert, B., Beerts, C., Vrolix, M., Mestdagh, I., Vervoort, G., van Welden, J., Vanwelden, J., Derycker, K., Vandekerckhove, Y., Jacobs, C., Mehrle, A., Skinner, J., Meholick, A., Marti, J., Mega, J., Lack, A., Stockman, D., Huyberechts, D., Scavee, C., Clinckemaille, N., Parque, J., Raepers, M., Mairesse, G., Malmendier, D., Herzet, J., Meeusen, K., Heidbuchel, H., Tincani, G., Desfontaines, P., De Bruyne, L., De Tollenaere, M., de Koning, K., De Bleecker, J., Banaeian, F., Capiau, L., O'Shea, V., Szto, G., Perrett, L., Purnell, P., Batta, C., Paul, V., Li, J., McKeirnan, M., Morrison, H., Wright, J., Wright, A., Chung, A., Watkin, R., Gilchrist, M., Venkataraman, A., Lehman, R., Jones, S., Gates, P., Flecknoe-Brown, S., Silver, G., Davis, S., Kay, S., Dart, A., Slattery, A., Crimmins, D., Price-Smith, S., Colquhoun, D., Hoffmann, B., Arstall, M., Paraskevaidis, T., Anderson, C., Morell, Y., Vico, M., Teves, M., Sosa Liprandi, M., Morara, P., Severino, P., Buzzetti, C., Schygiel, P., Walker, M., Turner, W., Bridge, C., Storey, R., Goloboulicz, A., Schmidberg, J., Kennard, S., Sopher, M., McLaurin, B., Young, G., Kwong, Winghan J., Antman, Elliott M., Ruff, Christian T., Wang, J. H., Iriarte, M., Morissette, A., Wang, Kaijun, Li, Haiyan, and Yalcin, R.
- Subjects
Male ,medicine.medical_specialty ,Complications ,Time Factors ,Pyridines ,Health Status ,Embolism ,Hemorrhage ,Arrhythmias ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Risk Factors ,Surveys and Questionnaires ,Internal medicine ,Atrial Fibrillation ,Humans ,Medicine ,In patient ,Prospective Studies ,030212 general & internal medicine ,anticoagulation ,Blood Coagulation ,Original Research ,Aged ,Aged, 80 and over ,Quality and Outcomes ,business.industry ,Anticoagulants ,Atrial fibrillation ,Middle Aged ,bleeding ,medicine.disease ,Stroke ,Thiazoles ,Treatment Outcome ,quality of life ,utility ,Physical therapy ,Cardiology ,Female ,Warfarin ,Gastrointestinal Hemorrhage ,Cardiology and Cardiovascular Medicine ,business ,TIMI ,Health Services and Outcomes Research ,Factor Xa Inhibitors - Abstract
Background The impact of different types of extracranial bleeding events on health‐related quality of life and health‐state utility among patients with atrial fibrillation is not well understood. Methods and Results The ENGAGE AF ‐ TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation–Thrombolysis in Myocardial Infarction 48) Trial compared edoxaban with warfarin with respect to the prevention of stroke or systemic embolism in atrial fibrillation. Data from the EuroQol‐5D ( EQ ‐5D‐3L) questionnaire, prospectively collected at 3‐month intervals for up to 48 months, were used to estimate the impact of different categories of bleeding events on health‐state utility over 12 months following the event. Longitudinal mixed‐effect models revealed that major gastrointestinal bleeds and major nongastrointestinal bleeds were associated with significant immediate decreases in utility scores (−0.029 [−0.044 to −0.014; P P =0.001], respectively). These effects decreased in magnitude over time, and were no longer significant for major nongastrointestinal bleeds at 9 months, but remained borderline significant for major gastrointestinal bleeds at 12 months. Clinically relevant nonmajor and minor bleeds were associated with smaller but measurable immediate impacts on utility (−0.010 [−0.016 to −0.005] and −0.016 [−0.024 to −0.008]; P Conclusions All categories of bleeding events were associated with negative impacts on health‐state utility in patients with atrial fibrillation. Major bleeds were associated with relatively large immediate decreases in utility scores that gradually diminished over 12 months; clinically relevant nonmajor and minor bleeds were associated with smaller immediate decreases in utility that persisted over 12 months. Clinical Trial Registration URL: https://www.clinicaltrials.gov/ . Unique identifier: NCT00781391.
- Published
- 2017
8. Outcomes With Edoxaban Versus Warfarin in Patients With Previous Cerebrovascular Events Findings From ENGAGE AF-TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48)
- Author
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Rostasne, Palinkas, A., Berk, M., Nagy, A., Garman, V., Bensimhon, D., Swaim, D., Beinart, S., Craig, M., Bedwell, N., Luis-Valdes, M., Bedoya, R., Hoffman, T., Beasley, R., Kolumban, E., Merkely, B., Kiss, K., Wulf, M., Takeda, M., Benton, J., Bartkowiak, A., Gordon, L., Erdogan, D., Barrington, P., Faircloth, C., Barker, T., Altonen, D., Barber, M., Campbell, G., Baman, R., Batista, M., Baine, S., Thompson, B., Ayesu, K., Ermis, C., Alvarez, M., Sanchez, A., Bowen, L., Sanjurjo, M., Codutti, O., Saravia Toledo, S., Formoso, I., Schmidberg, J., Baldwin, E., Awasty, V., Cobos, D., Aude, Y., Strickland, S., Medvegy, M., Kiss, T., Attanti, S., Matoltsy, A., Rasmussen, L., Arouni, A., Shoaf, R., Arnold, T., York, T., Kabul, K., Kanadasi, M., Goloboulicz, A., Anderson, J., Schygiel, P., Buzzetti, C., Severino, P., Morara, P., Sosa Liprandi, M., Teves, M., Vico, M., Oto, A., Turgut, O., Persechino, F., Morell, Y., Amin, K., Lane, B., Alsheikh, T., MacDonald, H., Almquist, A., Anderson, C., Paraskevaidis, T., Kolk, R., Tandogan, I., Stern, A., Yigit, F., Yigit, Z., Arstall, M., Hoffmann, B., Colquhoun, D., Price-Smith, S., Crimmins, D., Slattery, A., Karakai, H. Horvathne, Lupkovics, G., Di Lenarda, A., Kovacs, Z., Gadepalli, R., Mariani, M., Kumagai, S., Luttermann, M., Krishnan, H., Dart, A., Venneklaas, U., Kay, S., Lueders, S., De Servi, S., Grosse, B., Davis, S., Baranyai, M., Silver, G., Flecknoe-Brown, S., Gates, P., Kovacs, I., Salminen, O., Koczka, M., Jakal, A., Jones, S., Pirelli, S., Lohrbaecher-Kozak, I., Bauch, F., Koenig, H., Lehman, R., Kiss, R., Saha, D., Barai, A., Roy, D., Bekal, S., Feil, J. Felfoldine, Meusel, P., Morrison, H., Biscardi, R., Kis, E., Hirayama, A., Allison, J., Godsey, W., Aliyar, P., Genova-Peeva, E., Kosztyu, M., Kleinecke-Pohl, U., Alexander, J., Brubaker, S., Akhter, F., Schoen, B., Reddy, R., Shankar, A. Ravi, Jungmair, W., Schmid, S., Junggeburth, J., De Pace, D., Ahmadpour, H., De Caterina, R., Hussain, A., Kaik, J., Ahmad, A., Beck, P., Zoghi, M., Batushkin, V., Fink, P., Reiling, S., Miyamoto, N., Adler, P., McKeirnan, M., Li, J., Paul, V., Batta, C., Serup-Hansen, K., Vuriya, A., Horacek, T., Schuppe, M., Kanakaridisz, N., Varga, A., Kimizu, T., Purnell, P., Perrett, L., Kishore, R., Szto, G., O'Shea, V., Capiau, L., Banaeian, F., De Bleecker, J., de Koning, K., De Tollenaere, M., Kara, M., Fiok, J., Szatmari, J., De Bruyne, L., Edes, I., Tsukimine, A., Muskoczki, E., Wiggers, H., Jakobsen, U., Torp-Pedersen, C., Forgione, C., Harada, K., Dioszeghy, P., Almaraz, S. Padilla, Desfontaines, P., Tincani, G., Heidbuchel, H., Camas, L. Velasquez, Cuccia, C., Meeusen, K., Herzet, J., Malmendier, D., Guerra, L., Mairesse, G., Raepers, M., Parque, J., Clinckemaille, N., Scavee, C., Samayoa, C. Sanchez, Pozuelos, J. Mayen, Arakawa, S., Huyberechts, D., Stockman, D., Jacobs, C., Vandekerckhove, Y., Svenningsen, A., Sand, N., Azhdari, M., Derycker, K., Peruzzotti, L., Comi, G., Vanwelden, J., Mino, K., Cervi, E., Sanchez, M., Gilat, T., van Welden, J., Vervoort, G., Mestdagh, I., Vrolix, M., Bazylevych, A., Vlasyuk, Z., Raae, D., Raymond, I., Beerts, C., Wollaert, B., Denie, D., Vincenzo de Paola, A. Amato, Coutinho, E., Lotufo, P. Andrade, de Melo, R. Ferreira, Atie, J., Motta, C., Alves da Costa, F. Augusto, Lahav, M., Estrada, M. Rodas, Ferraz, R. Franchin, Precoma, D. Bertolim, Guevara, S., Contzen, C., Weihrauch, D., Sehnem, E., Botelho, R., Cunha, S., Brondani, R., Fleck, N., Buhr, M., Kandekar, S., Ladenburger, K., Lavagnino, A. Ovando, Braun, R., Ishimaru, S., Chaves Junior, H., Silva, J., Costantini, C., Barroso, D., Jimenez, T., De Patta, M., Pereira, V., Duda, N., Bereznyakov, I., Laimer, R., Tomita, H., Ishii, Y., Dutra, O., Morgado, S., Saporito, W. Faustino, Seroqui, M., Ferreira, L., Araujo, E., Finimundi, H., Daitz, C., Gagliardi, R., Pereira, G., Gomes, M., Gomes, A., Guimaraes, A., Lebedynskaya, M., Petrovic, V., Overgaard, K., Ninho, L., Olsen, R., Nielsen, H., Jaeger, C., Barash, B., Veng-Olsen, T., Dotsenko, S., Pereira, L., Iversen, H., Madsen, H., Kulynych, R., Dzyak, G., Vasilyeva, L., Faynyk, A., Sorokivskyy, M., Gavrysyuk, V., Schnelzer, P., Ibsen, H., Adler, J., Dzublik, Y., Horbach, L., Husyev, V., Bouzo, M., Babbar, A., Loof, A., Blanc, J., Godlevska, O., Melgar, I. Guzman, Marcoviciu, D., Ramirez, V. de Leon, Sehr, B., Beyer-Westendorf, J., Vierbeck, S., Decoulx, E., Samburg, Y., Jorge, J., Cury, C., Karpenko, O., Hassager, C., Milla, O. Ayau, Kaiser, S., Christensen, L., Christensen, H., Dodt, K., Zidkova, E., Samkova, D., Vodnansky, P., Almeida, A., Kalil, C., Radaelli, G., Sebba Barroso de Souza, W. Kunz, Morales, K., Labrova, R., Nevolina, I., Karpenko, Y., Leaes, P., Luiz, R. Osorio, Blihar, O., Kaydashev, I., Berbari, H., Spinar, J., Spacek, R., Almeida, J. Pimenta, Gozalo, A., Slaby, J., Reichert, P., Jirsova, E., Podrazil, P., Gerasimenko, N., Pisova, J., Exarchou, E., Havlova, I., Petrova, I., Kifnidis, K., Reis, G., Kolomyyits, S., Peterka, K., Olsr, J., Bansal, N., Nechanicky, R., Vasylets, V., Kopytsya, M., Melichar, M., Krocova, E., Machova, V., Ludka, O., Petyunina, O., Kotseruba, V., Berrouschot, J., Kvasnicka, J., Avellar, K., Kuchar, R., Kovar, P., Katz Weiand, L. Reis, Korantanis, K., Kosek, Z., Kostkova, G., Leipelt, J., Rocha, J., Ishibashi, Y., Lohman, J., Panella, M., Nozaki, T., Abi-Mansour, P., Dvoieglazova, M., Pyrgakis, V., Koval, V., Ohirko, O., Kochrt, M., Kobza, R., Koval', O., Jirmar, R., Sakamoto, S., Jerabek, O., Jelinek, Z., Jarkovsky, P., Jandik, J., Hubac, J., Honkova, M., Barros, R., Gregor, P., Rao, M., Jambula, H., Golan, L., Anzai, T., Rodrigues, L., Rocha, M. Rubia, Rodrigues, A., Rodrigues, D., dos Santos, F. Rossi, Pagnan, L. Goncalves, Sampaio, R., do Val, R., Saraiva, J., Francek, L., Florian, J., Ferkl, R., Elbl, L., Cermak, O., Burianova, H., Brtko, M., Pinto, B., and Yalcin, R.
- Subjects
Male ,medicine.medical_specialty ,Pyridines ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Brain Ischemia ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Double-Blind Method ,Recurrence ,Edoxaban ,Internal medicine ,Atrial Fibrillation ,parasitic diseases ,Secondary Prevention ,medicine ,Humans ,Myocardial infarction ,cardiovascular diseases ,Stroke ,Aged ,Advanced and Specialized Nursing ,business.industry ,Hazard ratio ,Warfarin ,Anticoagulants ,Atrial fibrillation ,Thrombolysis ,Middle Aged ,medicine.disease ,nervous system diseases ,Thiazoles ,Treatment Outcome ,chemistry ,Anesthesia ,Cardiology ,Female ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,030217 neurology & neurosurgery ,TIMI ,medicine.drug - Abstract
Background and Purpose— Patients with atrial fibrillation and previous ischemic stroke (IS)/transient ischemic attack (TIA) are at high risk of recurrent cerebrovascular events despite anticoagulation. In this prespecified subgroup analysis, we compared warfarin with edoxaban in patients with versus without previous IS/TIA. Methods— ENGAGE AF-TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48) was a double-blind trial of 21 105 patients with atrial fibrillation randomized to warfarin (international normalized ratio, 2.0–3.0; median time-in-therapeutic range, 68.4%) versus once-daily edoxaban (higher-dose edoxaban regimen [HDER], 60/30 mg; lower-dose edoxaban regimen, 30/15 mg) with 2.8-year median follow-up. Primary end points included all stroke/systemic embolic events (efficacy) and major bleeding (safety). Because only HDER is approved, we focused on the comparison of HDER versus warfarin. Results— Of 5973 (28.3%) patients with previous IS/TIA, 67% had CHADS 2 (congestive heart failure, hypertension, age, diabetes, prior stroke/transient ischemic attack) >3 and 36% were ≥75 years. Compared with 15 132 without previous IS/TIA, patients with previous IS/TIA were at higher risk of both thromboembolism and bleeding (stroke/systemic embolic events 2.83% versus 1.42% per year; P P P P =0.02). No treatment subgroup interactions were found for primary efficacy ( P =0.86) or for intracranial hemorrhage ( P =0.28). Conclusions— Patients with atrial fibrillation with previous IS/TIA are at high risk of recurrent thromboembolism and bleeding. HDER is at least as effective and is safer than warfarin, regardless of the presence or the absence of previous IS or TIA. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00781391.
- Published
- 2016
9. Cardioversion of Atrial Fibrillation in ENGAGE AF-TIMI 48
- Author
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- Published
- 2016
10. Stroke and Mortality Risk in Patients With Various Patterns of Atrial Fibrillation: Results From the ENGAGE AF-TIMI 48 Trial (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48)
- Author
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Jones, D., Gu, X. J., Liu, L., Grammer, M., Waseem, M., Roper, E., Harden, M., Zellner, C., Mason, T., Zeig, S., Curtis, S., Zakhary, B., Yousuf, K., Wharton, S., VonGerichten, S., Willis, J., Dowling, C., Williams, R., Gibson, C., Williams, D., Truva, C., Westcott, J., St Laurent, B., Weiss, R., Sanchez, G., Waxman, F., Locklear, T., Ward, S., Renaud, K., Walsh, R., Kilcup, S., Vossler, M., Washam, M., Vijay, N., Warren, K., Vicari, R., Parsons, T., Verma, S., Cardoza, T., Vemireddy, D., Harrelson, K. Gonzalez, Val-Mejias, J., Hanna, K., Updegrove, J., Salas, L., Tucker, P., Romero, N., Torres, M., Southam, D., Teixeira, J., Mitchell, T., Tee, H., Young, K., Teague, S., Dastoli, K., Tawney, K., Swauger, M., Tatarko, M., Corchado, D., Tami, L., Leo, L., Talano, J., Bruton, T., Takata, T., Springer, K., Tahirkheli, N., Herwehe, S., Szulawski, I., Freemyer, D., Swerchowsky, V., Frost, J., Suresh, D., Vittitow, T., Struble, R., Cox, C., Steljes, A., Liu, M., Staniloae, C., McCartney, P., Spivack, E., Vasquez, E., Sperling, M., Thomason, L., Spangenthal, S., Hodnett, P., Smith, R., Keene, R., Smith, S., Hughes, B., Skierka, R., Nelson, M., Singh, V., Turner, K., Singh, N., Meyer, R., Simpson, P., Champagne, M., Siler, T., Stephenson, L., Shoukfeh, M., Browning, J., Shih, H., Hengerer, T., Sheikh, K., Hren, A., Shaoulian, E., Fleets, J., Shanes, J., Seese, M., Shalaby, A., Witt, P., Shah, G., Mather, N., Seide, H., Holt, A., Ullig, T., Seals, A., Mercer, S., Schulman, D., Schneider, W., Schneider, R., Fekete, A., Schaefer, S., Clifton, R., Savin, V., Lafave, J., Sandberg, J., Schomburg, J., Samal, A., Ball, E., Sacco, J., Nelson, T., Ruoff, G., Freeman, R., Ross, S., Martin, C., Rosen, R., Barnhorst, M., Rosado, J., Hollihan, P., Roehll, W., Cherrico, M., Robinson, J., Braun, D., Riofrio, K., Roberts, J., Pazier, P., Richwine, R., Stanley, E., Renzi, M., Wroblewski, J., Redondo, V., Domingo, D., Rama, P., Hemmen, C., Quinn, J., Reed, C., Quinlan, E., Rafla, E., Quadrel, M., Ebert, J., Pugeda, J., Sham, L., Pudi, K., Lowe, K., Pribble, A., Neeper, L., Pratt, R., Cush, S., Poulathas, A., Kirk, D., Yovaniniz, P., Pezzella, S., Brown, F., Pettis, K., Morlando, F., Petruzziello, F., Chacon, L., Peters, P., Duncan, D., Pentz, W., Montayne, S., Pearlstein, R., Gorry, N., Pavon, H., Dennison, K., Patnam, S., Joseph, L., Oza, S., Gonzalez, M., Osborne, J., Garcia, L., Orchard, R., McCormick, J., Oppenheimer, K., Thakkar, N., Oberoi, M., Wilmot, M., Nielsen, R., Nomanee, S., Nguyen, T., Goza, J., Nallasivan, M., West, M., Naidu, J., Parker, A., Nadar, V., Oehmann, V., Murphy, A., Raziano, S., Mullen, P., Todd, S., Mowdy, M., Schuler, C., Mounsey, P., Parrott, N., Mouhaffel, A., Bowman, B., Morledge, J., Garner, S., Moran, J., Strugatsky, S., Mody, F., Gryczan, J., Miller, S., Sanchez, S., Miller, R., Sanders, D., Milas, J., Romero-Colon, J., Michlin, B., Cajulis, C., Mercado, A., Cervellione, K., Mendelson, R., Wall, J., Mehrle, A., Skinner, J., Meholick, A., Marti, J., Mega, J., Lack, A., McLaurin, B., Paul, J., McKnight, T., Rodkey, K., McKenzie, M., Miranda, J., McGuire, K., Schwarz, L., McGarvey, J., Stubbs, L., McCartney, M., Hicks, T., Massin, E., Bedenko, E., Marenberg, M., Rabadi-Marar, D., Marar, I., Hernandez, S., Mandviwala, M., Casas, R., Makam, S., Lisiecki, B., Mainigi, S., Doctor, A., Magee, A., Bush, D., Macomber, J., Edelstein, J., Lurie, M., Wright, H., Lui, H., Ault, S., Looby, R., Davids, M., Lone, B., Shah, D., Lomnitz, D., Wofford, E., Littlefield, R., Murphy, R., Ling, L., Miller, D., Lillestol, M., Bonds, C., Lewis, D., Hartley, L., Lesser, M., Smith, D., Lentz, M., Royse, H., Ledbetter, L., Faucett, S., Langevin, E., Simmons, T., Lang, J., Ferguson, D., Landau, C., Coyle, G. Stagi, Lambert, C., Jauregui, V., Laliotis, A., Marquez, D., Krichmar, P., Watts, S., Kozlowski, J., Sanchez, E., Kotha, P., Godfrey, C., Korpas, D., Averett, P., Kindman, L., Khan, G., Khan, M., Binns, M., Khan, B., DiCorcia, L., Kesselbrenner, M., Buhler, A., Kersh, R., Bartholomaus, D., Kerkering, M., Keller, J., Keller, R., Davis, C., Kastelic, R., Behm, K., Karunaratne, H., Ruggiero, M., Kapoor, A., Cook, S., Kaplan, K., Kostedt, G., Kandath, D., Dugal, J., Kai, W., Coombs, V., Kahn, B., Royes, A., Judson, P., Nichols, M., Jovin, I., Hughett, G., Jones, R., Phillips, T., Johnson, F., Andresen, T., Jardula, M., Butcher, S., Ison, R., Tambawala, M., Hussain, M., Garza, M., Hurst, P., Battistelli, E., Hunter, J., Huang, P., Craft, D., Howard, L., Hays, D., Howard, V., Adams, K., Houchin, V., Caterini, T., Turner, N., Hotchkiss, D., Sloss, D., Horton, K., Homayouni, A., Homan, J., Young, C., Hoekstra, J., Dutter, S., Hippert, R., Vieira, P., Hinchman, D., Carey, G., Herson, S., Miranda, D., Herrod, J., Batchell, K., Hermany, P., Harkins, V., Henry, S., Millard, D., Henderson, D., Dandekar, U., Heiman, M., Krater, C., Hearne, S., Bobade, M., Harris, J., Cavanna, L., Han, M., Bentivenga, L., Hamroff, G., Morelli, L., Hack, T., McLean, R., Gvora, T., Felsman, D., Guthrie, R., Foster, B., Guerrero, Guerrero, Fisher, M., Guarnieri, T., Gabela, W., Guarino, J., Mabe, K., Grove, D., Davis, A., Grossman, C., Goodman, V., Griffin, J., Aull, L., Griffin, S., Bonora, M., Graham, S., Rafala, E., Gowda, S., Goldstein, M., Latteri, J., Goldscher, D., Ewing, B., Gogia, H., Keane-Richmond, P., Gillespie, E., Hinchion, N., Gerber, J., Valentine, H., George, F., Garb, J., Jones, J., Gaffney, M., Smith, K., Friedlander, I., Morales, C., French, W., Gentry, P., Franco, M., Thrope, C., Frais, M., Solis, A., Forman, S., Slayton, C., Flores, E., Woodford, T., Zhang, Z., Lin, Y. N., Rupka, D., Donahue, S., Fishbein, G., Drew, B., Fischell, T., Zhang, H. Q., Lim, G., Finkelstein, S., Shriver, D., Finkel, M., Calvo, M., Fialkow, J., Prior, J., Felten, W., Tang, N., Feldman, J., Tameron, A., Feld, L., Watkins, D., Fahmy, R., DeSalle, D., Everhart, B., Shipp, A., Ettinger, N., O'Brien, J., Johnson, C., Qiang, H., Erenrich, N., Cristaldi, J., Ellis, J., Quick, R., Eldadah, Z., Dunn, K., Eade, J., Cullen, T., D'Souza, A., Habibi, S., Drozdiak, R., Olson, A., Dotani, I., Rodriguez, L., Donovan, D., Tisdale, L., DiGiovanna, M., Ucik, S., Dhar, S., Briscoe, C., Devenport, S., Waters, L., Desire, A., Steward, A., Desai, A., Carey, J., DeGarmo, R., Warmack, D., Dean, J., Debes, C., De Lemos, J., Ebreo, N., Davuluri, A., Dave, B., Dave, K., Wulf, A., Datta, S., Leka, G., Daniels, S., Morgan, T., Dang, N., Sarpola, N., Curtis, B., Nelson, L., Cowan, L., Masson, E., Cottiero, R., Mullinax, K., Cossu, S., Svadbik, L., Corbett, B., Martinez, E., Concha, M., Cole, J., Salpas, S., Colan, D., Bossaers, J., Cohen, R., Dutka, C., Cohen, A., McClelland, M., Clay, A., Clapp, T., Bagby, J., Ciaramita, J., Sawaya, K., Chaturvedi, S., Tamayo, M., Charlat, M., Hatfield, G., Chang, M., Phan, D., Carr, K., Jameson, L., Caplan, J., Hartranft, E., Canosa, R., Dickinson, D., Canaday, D., Morton, S., Cader, C., Al-Maliky, T., Bybee, K., Triano, A., Brown, H., Frey, W., Brilakis, E., Terry, P., Bradley, A., Ziegler, K., Bowden, W., Wade, W., Bouchard, A., Hickenbotham, D., Borsheim, M., Vernon, M., Blue, B., Bloomberg, K., Bloomberg, R., Ensminger, E., Blonder, R., Talbot-Lawson, C., Block, T., Antonino, M., Bingham, S., Langone, L., Bilazarian, S., Marchand, C., Preston, S., Bilal, B., Eldred, R., Bernard, J., Ibarra, M., Berk, M., Garman, V., Bensimhon, D., Swaim, D., Beinart, S., Craig, M., Bedwell, N., Luis-Valdes, M., Bedoya, R., Hoffman, T., Beasley, R., Benton, J., Bartkowiak, A., Gordon, L., Barrington, P., Faircloth, C., Barker, T., Altonen, D., Barber, M., Campbell, G., Baman, R., Batista, M., Baine, S., Thompson, B., Ayesu, K., Baldwin, E., Awasty, V., Cobos, D., Aude, Y., Strickland, S., Attanti, S., Rasmussen, L., Arouni, A., Shoaf, R., Arnold, T., York, T., Anderson, J., Persechino, F., Amin, M., Khetarpal, S., Amin, K., Lane, B., Alsheikh, T., MacDonald, H., Almquist, A., Biscardi, R., Allison, J., Godsey, W., Aliyar, P., Genova-Peeva, E., Alexander, J., Brubaker, S., Akhter, F., Ahmadpour, H., Hussain, A., Ahmad, A., Beck, P., Aggarwal, R., Reiling, S., Adler, P., Barash, B., Adler, J., Lohman, J., Panella, M., Abi-Mansour, P., Mackin, A., Moriarty, A., Green, M., Shandra, T., Zhurba, S., Logvinov, Y., Zharinov, O., Mudruk, I., Yena, L., Nahrebetskyy, V., Yagensky, A., Serik, S., Volkov, V., Goncharov, O., Vizir, V., Sklyanna, O., Vatutin, M., Drapchak, I., Vakaliuk, I., Tykhonova, S., Kuznetsov, I., Tseluyko, V., Lyzohub, S., Sychov, O., Perebetiuk, L., Stanislavchuk, M., Sirenko, Y., Zamlynskyy, M., Shvetz, N., Goncharova, I., Shcherbak, V., Ishchuk, V., Shatilo, V., Rudyk, I., Chendey, T., Rishko, M., Gamachek, O., Rebrov, B., Leonidova, V., Prokhorov, O., Nekrasa, A., Potapenko, P., Dovgan, N., Parkhomenko, A., Ushakova-Sokolova, L., Ostrovska, L., Fedotov, S., Malynovsky, Y., Gorna, O., Lizogub, V., Kyyak, Y., Kupnovytska, I., Stets, R., Kraydashenko, O., Usan, N., Kraiz, I., Kaplan, P., Koval', O., Ohirko, O., Koval, V., Dvoieglazova, M., Kotseruba, V., Petyunina, O., Kopytsya, M., Vasylets, V., Kolomyyits, S., Gerasimenko, N., Kaydashev, I., Blihar, O., Karpenko, Y., Nevolina, I., Karpenko, O., Samburg, Y., Godlevska, O., Husyev, V., Horbach, L., Dzublik, Y., Gavrysyuk, V., Sorokivskyy, M., Faynyk, A., Vasilyeva, L., Dzyak, G., Kulynych, R., Dotsenko, S., Lebedynskaya, M., Bereznyakov, I., Vlasyuk, Z., Bazylevych, A., Azhdari, M., Batushkin, V., Zoghi, M., Yigit, Z., Yigit, F., Tandogan, I., Turgut, O., Oto, A., Kanadasi, M., Kabul, K., Ermis, C., Erdogan, D., Ceyhan, C., Cayli, M., Calik, A., Cakmak, N., Bayata, S., Ata, N., Demir, H., Akilli, H., Acikel, M., Vorasettakarnkij, Y., Mekara, W., Sukonthasarn, A., Panpunuan, P., Sritara, P., Sripracha, A., Piyayotai, D., Bamrungpong, P., Laothavorn, P., Sriprasert, S., Kiatchoosakun, S., Sinthusopa, W., Kaewsuwanna, P., Pornchaiyasit, K., Jirasirirojanakorn, K., Kuo, J. Y., Yeh, H. I., Tsai, W. C., Wang, J. H., Lee, S. C., Ueng, K. C., Pan, Y. F., Tseng, W. K., Chiu, C. Z., Shyu, K. G., Lin, K. H., Pai, P. Y., Lee, J. T., Lin, T. H., Lai, W. T., Wang, C. L., Kuo, C. T., Mabee, J., Chen, Y. F., Huang, J. L., Chen, Y. P., Hsia, C. H., Yeh, T. C., Chiou, C. W., Wu, Y. W., Chiang, F. T., Yu, W. C., Chiang, C. E., Wu, W. S., Cheng, C. C., Slater, I. Petrova, Moccetti, T., Broberg, M., Thulin, J., Gunnarsson, A., Stenberg, A., Sundholm, C., Ronn, F., Johansson, M., Rautio, A., Moodh, J., Randers, F., Eriksson, G., Malmqvist, L., Edlund, M., Kozak, P., Hakansson, E., Koskinen, P., Jernhed, H., Juul-Moller, S., Winberg, L., Herlitz, J., Karlsson, L., Engdahl, J., Ostberg, S., Dettmann, S., Bengtsson, A. Stener, Carlsson, T., Persson, L., Blomstrom, P., Andersson, R., Blom, K. Berndtsson, Akerberg, A., Appelros, P., Astier, L., Villuendas, R., Dachs Delgado, M., Terns, M., Fernandez Alvarez, R., Fernandez, M., Arias, J., Diaz-Pintado, M., Merino, J., Blanco Abril, S., Manzano, L., Barquero, R., Lopez Garcia-Aranda, V., Delgado, A., Hernandez Madrid, A., Moure, M., Gonzalez Juanatey, J., Perez Guevara, M., Diez Tejedor, E., Asensio, A., De Arce Borda, A., Calvo, G., Calvo, C., Cabero, P., Bruguera Cortada, J., Puertas, I., Blanco Coronado, J., Manzanal Rey, A., Arcocha Torres, M., Kim, J. Y., Rim, S. J., Na, J. O., Rha, S. W., Kwak, J. J., Namgung, J., Shin, D. G., Lee, S. H., Joung, B. Y., Lee, M. H., Chun, M. Y., Kim, Y. J., Seo, J. B., Kim, S. H., Park, S. J., Kim, J. S., Park, J. H., Kim, J. H., Park, M. S., Kim, J. T., Cha, M. J., Kim, H. S., Seo, J. S., Kim, D. S., Jin, E. S., Kim, C. J., Choi, K. J., Kang, D. H., Lee, J. M., Jeon, H. K., Jung, J. W., Hyon, M. S., Lee, H. W., Hong, T. J., Lee, K. H., Han, S. H., Oh, Y. S., Chung, W. S., Hong, K. S., Choi, H. H., Ryu, D. R., Cho, B. R., Kim, D. H., Cha, J. K., Han, M. G., Bae, H. J., Wessels, L., Venter, T., Le Roux, M., Van Zyl, L., Goosen, Y., Van Der Merwe, N., Johnston, H., Soma, P., Munnik, M., Snyders, F., Duki, Y., Naidoo, D., Taljaard, J., Mitha, I., Kelfkens, Y., Wilson, L., Gani, M., Nunkoo, T., Essop, M., Mostert, M., Engelbrecht, J., Botha, L., Ellis, G., Allman, J., Dalby, A., Poynton, M., Basson, M., Erasmus, L., Badenhorst, J., Bollova, D., Zareczky, P., Kokles, M., Zachar, A., Kmec, J., Slanina, M., Morsky, J., Ruffini, L., Fedacko, J., Pella, D., Mazur, J., Reptova, A., Kasperova, V., Hofmanova, J., Hranai, M., Hatala, R., Hatalova, K., Dzupinova, M., Dzupina, A., Vankova, L., Duris, T., Dulka, T., Dulkova, K., Kosmalova, V., Dukat, A., Banikova, A., Ambrovic, I., Ambrovicova, V., Tesic, M., Golshmid, M., Ruda, M., Topolnitchi, O., Castro, C., Ostojic, M., Tesic, B. Vujisic, Mitrovic, P., Vasiljevic-Pokrajcic, Z., Davicevic, Z., Tavciovski, D., Milinkovic, I., Seferovic, P., Kalezic, T., Putnikovic, B., Polovina, M., Potpara, T., Tasic, N., Otasevic, P., Djokic, I., Miloradovic, V., Djokovic, A., Krotin, M., Ilic, B., Ilic, S., Erceg, P., Despotovic, N., Bjelobrk, M., Adjic, N. Cemerlic, Majstorovic, A., Celic, V., Djordjevic-Radojkovic, D., Apostolovic, S., Motylev, I., Zubeeva, G., Kononenko, O., Zenin, S., Mankhaeva, B., Zateyshchikova, A., Zotova, I., Zateyshchikov, D., Nikulina, N., Yakushin, S., Petrochenko, A., Yakusevich, V., Rodina, N., Volkov, D., Kirgizova, A., Vishnevsky, A., Rossovskaya, M., Ustyugov, S., Bulygin, S., Timofeev, A., Solovyev, A., Tikhonova, E., Kositsyna, I., Tereshenko, S., Isakov, L., Tarasov, N., Gonzales, C., Dronov, D., Suprun, E., Erofeeva, S., Sobolev, K., Lapidus, N., Sizova, Z., Orlov, V., Sinitsina, I., Vorontsova, S., Sidorenko, B., Agirov, M., Shogenov, Z., Lebedev, E., Shaposhnik, I., Repin, M., Karoli, N., Rebrov, A., Letaeva, M., Raskina, T., Pikalova, N., Poluyanova, N., Matveeva, I., Polkanova, E., Nilk, R., Panov, A., Laguta, P., Panchenko, E., Patrusheva, S., Novikova, N., Khromova, O., Nikolskaya, I., Nikolaev, A., Nikolaev, K., Lamden, D., Lukyanov, Y., Belousova, L., Lila, A., Moiseeva, Y., Libov, I., Maslova, A., Libis, R., Volkova, E., Levashov, S., Tereschenko, L., Lavrova, O., Rychkov, A., Kuznetsov, V., Kostenko, O., Kozyrev, O., Polyanskaya, E., Koziolova, N., Karabalieva, S., Kostenko, V., Khrustalev, A., Khrustalev, O., Tsareva, E., Khokhlov, R., Sinitsina, O., Khokhlov, A., Kireenkov, I., Khirmanov, V., Kosenko, B., Buza, V., Karpov, Y., Mazovets, O., Gratsiansky, N., Laptev, I., Goloshchekin, B., Kratskina, T., Golitsyn, S., Valovyeva, S., Glezer, M., Valuyshkih, E., Gilinskaya, O., Soin, I., Filatov, A., Kirichek, N., Esip, V., Egorova, L., Zyatenkova, E., Drapkina, O., Puchinyan, N., Dovgalevsky, P., Masin, A., Demko, A., Pokutneva, O., Chumakova, G., Khlevchuk, T., Bokarev, I., Yukhno, E., Berns, S., Kosolapov, Y., Belenky, D., Larina, V., Bart, B., Bashkireva, A., Barbarash, O., Alexandrova, L., Ballyuzek, M., Chernyavskaya, T., Arutyunov, G., Zhukova, N., Tudoran, C., Tudoran, M., Topolnitchi, L., Spinu, C., Stamate, S., Plosca, P., Sipciu, D., Ardelean, A., Popescu, M., Cozma, M., Pop, C., Serban, D., Minescu, B., Costache, L., Iosipescu, L., Jurca, S., Dragomir, D., Sirbu, I., Dobreanu, D., Voicu, O., Kang, H., Dobre, I., Jemna, D., Crisu, D., Anciu, M., Cristea, M., Parasteac, M., Creteanu, M., Constantinescu, M., Ghionea, M., Coman, I., Andor, M., Ciobotaru, G., Bolohan, F., Doka, B., Bobescu, E., Ochean, V., Bengus, C., Badila, E., Bartos, D., Matei, C., Apetrei, E., Ciortea, M., Albulescu, P., Soares, D., Santos, J., Veiga Pais Nunes, L., Santos, O., Goncalves, A., Salgado, A., Leitao Marques, A., Oliveira, D., Monteiro, P., Neves, E., Martins, D., Maymone, D., Madeira, J., Lopes, S., Gil, V., Correia, J., Matias, F., Nawrot, M., Zielinski, M., Krauze, R., Zarebinski, M., Kudlicki, J., Wysokinski, A., Muzalewski, P., Wrobel, W., Turbak, R., Malanska, A., Szolkiewicz, M., Spyra, J., Sendrowski, D., Norwa-Otto, B., Ruzyllo, W., Ronkowski, R., Rozmyslowicz-Szerminska, W., Rewinska, H., Zienciuk-Krajka, A., Raczak, G., Bojanowska, E., Polaszewska-Pulkownik, V., Pogorzelska, H., Janczewska, D., Podjacka, D., Olszewski, M., Nowak, J., Nej, A., Niezgoda, K., Nessler, B., Nessler, J., Biniek, D., Napora, P., Myslinski, W., Mosiewicz, J., Kosmalska, K., Miekus, P., Chmielowski, A., Mazur, S., Meissner, G., Kosmaczewska, A., Wnetrzak-Michalska, R., Sznajder, R., Matyszczak-Toniak, L., Jaguszewska, G., Lysek, R., Szymanska, K., Lubinski, A., Stopyra-Poczatek, M., Lewczuk, J., Wierzykowski, T., Lesnik, J., Kus, W., Sklodowskiej-Curie, M., Muzyk-Osikowicz, M., Krzyzanowski, W., Borowski, W., Korzeniak, R., Benicka, E., Konieczny, M., Kaliszczak, R., Karczmarczyk, A., Tymendorf, K., Kania, G., Kaminski, L., Pacholska, A., Kaczmarek, B., Jurowiecki, J., Ciezak, P., Jazwinska-Tarnawska, E., Makowiecka-Ciesla, M., Januszewicz, A., Mroczkowski, P., Gniot, J., Zajac, E., Gieroba, A., Guziewicz, M., Domanska, E., Laskowska-Derlaga, E., Derlaga, B., Ptak, A., Dabrowska, M., Cymerman, K., Krzystolik, A., Busz-Papiez, B., Cieslak, B., Bronisz, M., Baszak, J., Korzeniowska-Adamus, J., Adamus, J., Nario, K., Villamor, L., Aquino, M., To, R., Gilo, L., Roxas, A., Joaquin, F., Rogelio, G., Enad, C., Matiga, G., Vallenas, M., Coching, R., Zapanta, M., Barcinas, R., Sambaz, C. 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F., Le Heuzey, J., Nappila, H., Virtanen, V., Salminen, O., Rasi, H., Sankari, T., Nyman, K., Viitaniemi, J., Maenpaa, A., Laheaar, M., Lucijanic, T., Lappalainen, T., Jakala, P., Valpas, S., Hussi, E., Kaarleenkaski, S., Huikuri, H., Ratnik, E., Vahula, V., Rajasalu, R., Rosenthal, A., Voitk, J., Paumets, M., Rivis, L., Laane, E., Kolk, R., Stern, A., Kaik, J., Serup-Hansen, K., Wiggers, H., Jakobsen, U., Torp-Pedersen, C., Giesbrecht, L., Bagatin, J., Svenningsen, A., Carevic, V., Jiang, X. J., Sand, N., Raae, D., Raymond, I., Petrovic, V., Overgaard, K., Olsen, R., Nielsen, H., Veng-Olsen, T., Talajic, M., Iversen, H., Madsen, H., Ibsen, H., Loof, A., Hassager, C., Christensen, L., Christensen, H., Dodt, K., Zidkova, E., Samkova, D., Vodnansky, P., Labrova, R., Spinar, J., Spacek, R., Slaby, J., Reichert, P., Jirsova, E., Podrazil, P., Pisova, J., Havlova, I., Petrova, I., Peterka, K., Olsr, J., Nechanicky, R., Melichar, M., Krocova, E., Machova, V., Ludka, O., Kvasnicka, J., Kuchar, R., Kovar, P., Kosek, Z., Kostkova, G., Kochrt, M., Kobza, R., Jirmar, R., Jerabek, O., Jelinek, Z., Jarkovsky, P., Jandik, J., Hubac, J., Honkova, M., Gregor, P., Campisto, Y., Morissette, A., Sussman, J., Gao, M., Frahm, E., Golan, L., Mitrovic, V., Zheng, Y., Zapata Staub, J., Zheng, X., Francek, L., Florian, J., Ferkl, R., Elbl, L., Cermak, O., Burianova, H., Brtko, M., Kailey, P., Retamal Matus, L., Fonseca, J., Han, R. J., Velthuysen, G., Bugueno, C., Orozco Linares, L., Bobbie, C., Heath, J., Lopez Giraldo, D., Raddatz, K., Zhao, X. L., Voehringer, Voehringer, Scott, L., Ho, K., Ho, V., Chen, X. P., Car, S., Hoag, G., Bolton, R., O'Mahony, W., Banville, P., O'Hara, G., Nicholson, R., Lamoureux, U., Kunkelova, V., Najarali, A., Mucha, M., Roth, M., Morrison, D., Morely, A., Mawji, A., Studenikow, E., Maranda, C., Vaillancourt, T., Zhang, X., Dong, Y. G., Standring, R., Feng, C., Fu, G. S., Wang, J. Q., Beeton, I., Dunn, S., Blagden, M., Price, R., Camm, J., Dougal, K., Mondaca Mondaca, P., Chapman, O., Davies, D., Choy, A., Duff, J., Zheng, Z. Q., Wilmott, R., D'Costa, D., Douglas, H., Lie, F., Ramasamy, V., Lindsay, S., Atkinson, C., Moncada Corredor, M., Linker, N., Finlayson, M., Lip, G., Brown, R., MacCallum, P., Ebano, P., MacLeod, M., McGhee, C., Marazzi, P., Maxwell, T., Isted, C., More, R., Helliwell, L., Murdoch, D., Andrews, A., Newby, D., Flint, L., Pye, M., Wright, L., Avery, D., Senior, R., Young, G., Sopher, M., Kennard, S., Storey, R., Zhang, P., Bridge, C., Hong, K., Turner, W., Walker, M., Venkataraman, A., Gilchrist, M., Watkin, R., Chung, A., Wright, A., Wright, J., Cobos, J., Mueller-Glamann, M., Yang, Y. J., Jeric, M., Li, A. Y., Yang, K., Liang, Y. Z., Xu, Y. M., Gu, J. Y., Berka, L., Xu, J. H., You, Z. G., Li, Y. E., Syan, G., Hoefer, K., Rivera Rodriguez, E., Brodova, P., Ludwig, I., Obreque, C., Manzur, F., Builes, A., Hoffmann, U., Jaramillo Munoz, C., Dorn, S., Veltkamp, R., Hoffmann, S., Li, B. G., Potthoff, S., Bar, M., Vogt, S., Delgado, P., Zhou, S. X., Schuppe, M., Bergovec, M., Muegge, A., Teitelbaum, J., Barbera, S., Horacek, T., Torres Carrasco, G., Vrazic, H., Zhang, Y. L., Ciglenecki, N., Liao, D. N., Pincetti, C., Fink, P., Teitelbaum, I., Carmona Perez, M., Junggeburth, J., Liu, Y., Schmid, S., Li, Z. Q., Jungmair, W., Spitzer, S., Opazo, M., Lu, Z. H., Tusek, S., Ferri Certic, J., Romic, I., Francetic, I., Makar Ausperger, K., Jelic, V., Jaksic Jurinjak, S., Knezevic, A., Lichtenstein, T., Lam, H., Bakliza, Z., Sutalo, K., Lam, S., Romero Llamas, R., Ma, S. M., Huynh, T., St-Germain, L., Luton, R., Accini, J., Lainesse, A., Perkins, L., Douglas, S., Dewar, C., Ma, P., Kouz, S., Kirner, D., Steiner, R., Matthews, J., MacCallum, C., Cvitkusic Lukenda, K., Schoen, B., Kleinecke-Pohl, U., Meusel, P., Koenig, H., Bauch, F., Lohrbaecher-Kozak, I., Grosse, B., Lueders, S., Venneklaas, U., Luttermann, M., Wulf, M., Maus, O., Seib, M., Malette, P., Roberts, P., Yang, Z. Y., Roy, M., Labonte, R., Kong, Y. Q., Samardzic, P., Qu, Z., Hong, L., Buksa, B., Qiu, Y., Tremblay, M., Talbot, P., Accini, M., Hernandez, H., Wang, D. M., Qi, S. Y., Corbalan, R., Wang, G. P., Cano, N., Aldana Diaz, I., Shi, X. J., Martinez, D., Wu, S. L., Fernandez Ruiz, R., Manriquez Silva, L., Manriquez, L., Rebolledo, C., Wei, M., Leon Pineda, L., Arroyave, C., Lopetegui, M., Arratia Diaz, P., Huang, D., Florenzano, F., Parada, A., Bonin, K., Delgado Restrepo, J., Stoehring, R., Taggeselle, J., Zarpentin, C., Huikuri, Heikke, Puripun, E., Yarows, S., Giugliano, Robert P., Scirica, Benjamin M., Wood, K., Sheehan, T., Yasin, M., Worley, S., Ruff, Christian T., Link, Mark S., Pointer, S., Capasso-Gulve, E., Yi, J., Dongas, B., and Yalcin, R.
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Male ,medicine.medical_specialty ,medicine.drug_mechanism_of_action ,Pyridines ,medicine.medical_treatment ,Factor Xa Inhibitor ,Hemorrhage ,030204 cardiovascular system & hematology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Edoxaban ,Risk Factors ,Physiology (medical) ,Internal medicine ,Thromboembolism ,Atrial Fibrillation ,Medicine ,Humans ,atrial fibrillation ,cardiovascular diseases ,030212 general & internal medicine ,Myocardial infarction ,Stroke ,Aged ,business.industry ,Warfarin ,Anticoagulants ,Atrial fibrillation ,Thrombolysis ,thromboembolism ,bleeding ,medicine.disease ,mortality ,stroke ,Thiazoles ,Treatment Outcome ,chemistry ,Anesthesia ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,TIMI ,medicine.drug ,Factor Xa Inhibitors - Abstract
Background— Whether the pattern of atrial fibrillation (AF) modifies the risk/benefit of anticoagulation is controversial. In ENGAGE AF-TIMI 48 trial (Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation–Thrombolysis in Myocardial Infarction 48), the factor Xa inhibitor edoxaban was noninferior to warfarin in preventing stroke or systemic embolic events and significantly reduced bleeding and cardiovascular mortality. However, detailed analyses by AF pattern have not been reported. Methods and Results— The 21 105 patients were categorized as having paroxysmal (P -adj =0.015) and permanent AF (1.95%/year; P -adj =0.004). Overall, all-cause mortality also was lower with paroxysmal (3.0%/year) compared with persistent (4.4%/year; P -adj P -adj Conclusions— In ENGAGE AF-TIMI 48 trial, patients with paroxysmal AF suffered fewer thromboembolic events and deaths compared with those with persistent and permanent AF. The efficacy and safety profile of edoxaban as compared with warfarin was consistent across the 3 patterns of AF. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00781391.
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- 2016
11. O Sistema Nacional de Pesquisa Agropecuária: proposta de implentação para um novo modelo de gestão e governança
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CANCIANI, A., CURY, C., CARVALHO, L. N., ALINE CANCIANI, Organização Social Catavento Cultural e Educacional, CYNTHIA CURY, CPPSE, and LUCIANA NEVES CARVALHO, Governo do Estado de São Paulo - Secretaria da Fazenda.
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Governance ,Pesquisa e inovação agropecuária ,Governança ,Gestão e governança ,Pesquisa Agrícola ,Organizações Estaduais de Pesquisa Agropecuária - Abstract
A agropecuária há muitos anos vem desempenhando um papel de grande relevância para o crescimento econômico brasileiro, possibilitando ao país ser um dos maiores exportadores mundiais de produtos agrícolas. Uma importante estrutura que contribui para este resultado positivo é o Sistema Nacional de Pesquisa Agropecuária (SNPA), que atualmente se encontra fragilizado devido à falta de coordenação e cooperação entre os atores, além da redução de recursos. Neste contexto, o Centro de Gestão e Estudos Estratégicos (CGEE), propôs uma alternativa de arranjo para a pesquisa agropecuária, que compreende a estruturação, no médio e longo prazo, de uma plataforma, que possibilitará a articulação, alinhamento e sinergia entre os atores envolvidos no processo de pesquisa e inovação para a agricultura do País. Este trabalho objetiva apresentar uma proposta de implementação, no curto prazo, para se alcançar o modelo formulado pelo CGEE. Realizamos um estudo de caso sobre o SNPA, por meio de uma breve revisão bibliográfica de conceitos pertinentes às necessidades de análise do Sistema. Descrevemos os principais eventos da trajetória do SNPA ocorridos entre 1972 e 2015 para entender seu funcionamento e sua dinâmica. A análise do Sistema foi realizada por meio do estudo de artigos, livros e teses sobre o caso e, em especial, por meio das entrevistas efetuadas com diferentes atores que representam o Sistema: acadêmicos, dirigentes e colaboradores das Organizações Estaduais de Pesquisa Agropecuária (OEPAs), dirigentes dos conselhos de representação, gestores públicos e representantes do setor privado. Constatamos que a implementação do modelo, para ser factível no curto prazo, deveria ser realizada por uma instituição que ocupasse papel preponderante no SNPA e que já dispusesse de mecanismos legais e de capacidade técnico-operacional necessários à validação e à execução do novo modelo. Foi possível identificar também a necessidade de inovações institucionais e organizacionais do Sistema, principalmente para atender às demandas dos produtores e da sociedade. Por fim, uma das mais relevantes constatações é a de que: a efetividade do novo arranjo só ocorrerá se as instituições e atores envolvidos se reconhecerem como coautores, tiverem proatividade e perceberem seu papel e suas responsabilidades. Orientada por Ana Cristina Braga Martes, FGV.
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- 2016
12. Cerebrovascular events in 21 105 patients with atrial fibrillation randomized to edoxaban versus warfarin: Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48
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Dougal, K., Venkataraman, A., Murdoch, D., Blagden, M., Dunn, S., MacCallum, P., Young, G., Lip, G., Senior, R., Brown, R., Sopher, M., Ebano, P., Linker, N., Atkinson, C., Lindsay, S., MacLeod, M., More, R., Ramasamy, V., Chapman, O., Lie, F., Beeton, I., McGhee, C., Wilmott, R., Dickinson, D., Douglas, H., Davies, D., D'Costa, D., Finlayson, M., Wright, A., Avery, D., Wright, L., Pye, M., Marazzi, P., Flint, L., Newby, D., Kennard, S., Andrews, A., Storey, R., Helliwell, L., Bridge, C., Choy, A., Turner, W., Walker, M., Wright, J., Smith, S., Jones, D., Maxwell, T., Chung, A., Isted, C., Cohen, A., Camm, J., Price, R., Watkin, R., Gilchrist, M., Duff, J., Aggarwal, R., Eldred, R., Adler, P., Chehayeb, R., Vandekerckhove, Y., Gordon, L., Jones, S., Young, C., Coyle, G. Stagi, Ferguson, D., Lang, J., Simmons, T., Langevin, E., Faucett, S., Ledbetter, L., Royse, H., Lentz, M., Smith, D., Lesser, M., Hartley, L., Lewis, D., Bonds, C., Lillestol, M., Miller, D., Ling, L., Murphy, R., Littlefield, R., Wofford, E., Lomnitz, D., Shah, D., Lone, B., Davids, M., Looby, R., Ault, S., Lui, H., Wright, H., Lurie, M., Edelstein, J., Macomber, J., Bush, D., Magee, A., Doctor, A., Mainigi, S., Lisiecki, B., Makam, S., Casas, R., Mandviwala, M., Hernandez, S., Marar, I., Rabadi-Marar, D., Marenberg, M., Bedenko, E., Massin, E., Hicks, T., McCartney, M., Stubbs, L., McGarvey, J., Schwarz, L., McGuire, K., Miranda, J., McKenzie, M., Rodkey, K., McKnight, T., Paul, J., McLaurin, B., Lack, A., Mega, J., Marti, J., Meholick, A., Skinner, J., Mehrle, A., Wall, J., Mendelson, R., Cervellione, K., Mercado, A., Cajulis, C., Michlin, B., Romero-Colon, J., Milas, J., Sanders, D., Miller, R., Sanchez, S., Miller, S., Gryczan, J., Mody, F., Strugatsky, S., Moran, J., Garner, S., Morledge, J., Bowman, B., Mouhaffel, A., Parrott, N., Mounsey, P., Schuler, C., Mowdy, M., Todd, S., Mullen, P., Raziano, S., Murphy, A., Oehmann, V., Nadar, V., Parker, A., Naidu, J., West, M., Nallasivan, M., Goza, J., Nguyen, T., Nomanee, S., Nielsen, R., Wilmot, M., Oberoi, M., Thakkar, N., Oppenheimer, K., McCormick, J., Orchard, R., Garcia, L., Osborne, J., Gonzalez, M., Oza, S., Joseph, L., Patnam, S., Dennison, K., Pavon, H., Gorry, N., Pearlstein, R., Montayne, S., Pentz, W., Duncan, D., Peters, P., Chacon, L., Petruzziello, F., Morlando, F., Pettis, K., Brown, F., Pezzella, S., Kirk, D., Poulathas, A., Cush, S., Pratt, R., Neeper, L., Pribble, A., Lowe, K., Pudi, K., Sham, L., Pugeda, J., Ebert, J., Quadrel, M., Rafla, E., Quinlan, E., Reed, C., Quinn, J., Hemmen, C., Rama, P., Domingo, D., Redondo, V., Wroblewski, J., Renzi, M., Stanley, E., Richwine, R., Pazier, P., Roberts, J., Riofrio, K., Braun, D., Robinson, J., Cherrico, M., Roehll, W., Hollihan, P., Rosado, J., Barnhorst, M., Rosen, R., Martin, C., Ross, S., Freeman, R., Ruoff, G., Nelson, T., Sacco, J., Ball, E., Samal, A., Schomburg, J., Sandberg, J., Lafave, J., Savin, V., Clifton, R., Schaefer, S., Fekete, A., Schneider, R., Schneider, W., Schulman, D., Mercer, S., Seals, A., Ullig, T., Holt, A., Seide, H., Mather, N., Shah, G., Witt, P., Shalaby, A., Seese, M., Shanes, J., Fleets, J., Shaoulian, E., Hren, A., Sheikh, K., Hengerer, T., Shih, H., Browning, J., Shoukfeh, M., Stephenson, L., Siler, T., Champagne, M., Simpson, P., Meyer, R., Singh, N., Turner, K., Singh, V., Nelson, M., Skierka, R., Hughes, B., Keene, R., Smith, R., Hodnett, P., Spangenthal, S., Thomason, L., Sperling, M., Vasquez, E., Spivack, E., McCartney, P., Staniloae, C., Liu, M., Steljes, A., Cox, C., Struble, R., Vittitow, T., Suresh, D., Frost, J., Swerchowsky, V., Freemyer, D., Szulawski, I., Herwehe, S., Tahirkheli, N., Springer, K., Takata, T., Bruton, T., Talano, J., Leo, L., Tami, L., Corchado, D., Tatarko, M., Swauger, M., Tawney, K., Dastoli, K., Teague, S., Young, K., Tee, H., Mitchell, T., Teixeira, J., Southam, D., Torres, M., Romero, N., Tucker, P., Salas, L., Updegrove, J., Hanna, K., Val-Mejias, J., Harrelson, K. Gonzalez, Vemireddy, D., Cardoza, T., Verma, S., Parsons, T., Vicari, R., Warren, K., Vijay, N., Washam, M., Vossler, M., Kilcup, S., Walsh, R., Renaud, K., Ward, S., Locklear, T., Waxman, F., Sanchez, G., Weiss, R., St Laurent, B., Westcott, J., Truva, C., Williams, D., Gibson, C., Williams, R., Dowling, C., Willis, J., VonGerichten, S., Wood, K., Capasso-Gulve, E., Worley, S., Pointer, S., Yarows, S., Sheehan, T., Yasin, M., Preston, S., Yi, J., Dongas, B., Yousuf, K., Fisher, M., Zakhary, B., Curtis, S., Zeig, S., Mason, T., Zellner, C., Harden, M., Roper, E., Waseem, M., Grammer, M., Ruff, Christian T., Giugliano, Robert P., Beerts, C., Vrolix, M., Mestdagh, I., Vervoort, G., van Welden, J., Vanwelden, J., Derycker, K., Jacobs, C., Stockman, D., Huyberechts, D., Scavee, C., Clinckemaille, N., Parque, J., Raepers, M., Mairesse, G., Malmendier, D., Herzet, J., Meeusen, K., Heidbuchel, H., Tincani, G., Desfontaines, P., De Bruyne, L., De Tollenaere, M., de Koning, K., De Bleecker, J., Banaeian, F., Capiau, L., O'Shea, V., Szto, G., Perrett, L., Purnell, P., Batta, C., Paul, V., Li, J., McKeirnan, M., George, F., Valentine, H., Gerber, J., Hinchion, N., Morrison, H., Lehman, R., Gates, P., Flecknoe-Brown, S., Silver, G., Davis, S., Kay, S., Dart, A., Slattery, A., Crimmins, D., Price-Smith, S., Colquhoun, D., Hoffmann, B., Arstall, M., Paraskevaidis, T., Anderson, C., Morell, Y., Vico, M., Teves, M., Sosa Liprandi, M., Morara, P., Severino, P., Buzzetti, C., Schygiel, P., Goloboulicz, A., Schmidberg, J., Formoso, I., Saravia Toledo, S., Codutti, O., Sanjurjo, M., Gillespie, E., Keane-Richmond, P., Gogia, H., Ewing, B., Goldscher, D., Latteri, J., Goldstein, M., Bowen, L., Sanchez, A., Alvarez, M., Rodriguez, M., Navarrete, S., Ramos, H., Venturini, C., Prado, A., Fernandez, E., Pozzer, D., Casares, E., Povedano, G., Tommasi, A., Piskorz, D., Verdini, E., Nul, D., Gandur, H., Muntaner, J., Funes, I., Marino, J., Calderon, M., Manuale, O., Carne, M., Mackinnon, I., Raimondi, G., Lotti, J., Shatsky, K., Lorente, C., Vignau, S., Llanos, J., Nigro, A., Litvak, B., Iglesias, M., Liniado, G., Belcuore, M., Lanternier, G., Monaco, F., Kevorkian, R., Jure, D., Jure, H., Bianchini, M., Hominal, M., von Wulffen, M., Goicoechea, R., Huerta, M., Giannaula, R., Eden, M., Giacomi, G., Ceirano, C., Garrido, M., Perlo, D., Garcia Duran, R., Meiller, F., Gant Lopez, J., Zanotti, A., Fuselli, J., Arrieta, M., Femenia, F., Iriarte, M., Falu, E., Facello, M., Facello, A., Davolos, M., Estol, C., Moreno, V., Dran, R., Cendali, G., D'Amico, A., Bocanera, M., Cuneo, C., Rosell, M., Cuello, J., Morandini, M., Colombo, H., Saa Zarandon, R., Caruso, O., Novas, V., Cartasegna, L., Fracaro, V., Caccavo, A., Saravia, M., Bustamante Labarta, G., Valle, M., Budassi, N., Berli, M., Petrucci, J., Beloscar, J., Caceres, M., Amuchastegui, M., Ameriso, P., Ameriso, S., Garcia, M., Alvarez, C., Reguero, M., Allall, O., Rosales, E., Albisu, J., Ahuad Guerrero, R., Gonzalez, C., Vogelmann, O., Braunwald, Eugene, Antman, Elliott M., Mercuri, Michele, Shi, Minggao, Dave, Jay, Duggal, Anil, Betcher, Joshua M., Grip, Laura T., Murphy, Sabina A., Deenadayalu, Naveen, Lowe, Cheryl, Wiviott, Stephen D., Silverman, Scott, Gowda, S., Rafala, E., Graham, S., Bonora, M., Griffin, S., Aull, L., Griffin, J., Goodman, V., Grossman, C., Davis, A., Grove, D., Mabe, K., Guarino, J., Gabela, W., Guarnieri, T., Guerrero, Guerrero, Foster, B., Guthrie, R., Felsman, D., Gvora, T., McLean, R., Rost, Natalia S., Hack, T., Morelli, L., Hamroff, G., Bentivenga, L., Han, M., Cavanna, L., Harris, J., Bobade, M., Hearne, S., Krater, C., Heiman, M., Dandekar, U., Henderson, D., Millard, D., Henry, S., Harkins, V., Hermany, P., Batchell, K., Herrod, J., Miranda, D., Herson, S., Carey, G., Hinchman, D., Vieira, P., Hippert, R., Dutter, S., Hoekstra, J., Homan, J., Homayouni, A., Horton, K., Sloss, D., Hotchkiss, D., Turner, N., Houchin, V., Adams, K., Howard, V., Hays, D., Howard, L., 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Avraham, Elias, M., Gilat, T., Lahav, M., Marcoviciu, D., Dicker, D., Lasri, E., Atar, S., Dharmarao, A., Zanwar, I., Thakur, B., Vinod, M. Vijan, Kaur, A., Varma, S., Thankaraj, L., Srinivas, A., Gupta, R., Singh, G., Sudheer, R., Shetty, G., Sethia, S., Sethia, A., Bansal, N., Sethi, K., Singh, R., Sawhney, J., Arora, T., Sarna, M., Jadhav, D., Sant, H., Gadepalli, R., Saha, D., Barai, A., Roy, D., Bekal, S., Reddy, R., Shankar, A. Ravi, Vuriya, A., Rao, M., Jambula, H., Premchand, R., Kharalkar, H., Pinto, B., Babbar, A., Patki, N., Jasani, B., Parekh, P., Sababathi, R., Pandurangi, U., Shams, S., Purayil, M. 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Rostasne, Palinkas, A., Nagy, A., Kolumban, E., Merkely, B., Kiss, K., Medvegy, M., Kiss, T., Matoltsy, A., Karakai, H. Horvathne, Lupkovics, G., Kovacs, Z., Baranyai, M., Kovacs, I., Koczka, M., Jakal, A., Kiss, R., Feil, J. Felfoldine, Kis, E., Kosztyu, M., Kanakaridisz, N., Varga, A., Fiok, J., Szatmari, J., Edes, I., Muskoczki, E., Dioszeghy, P., Almaraz, S. Padilla, Camas, L. Velasquez, Guerra, L., Samayoa, C. Sanchez, Pozuelos, J. Mayen, Sanchez, M., Estrada, M. Rodas, Guevara, S., Lavagnino, A. Ovando, Jimenez, T., Melgar, I. Guzman, Ramirez, V. de Leon, Milla, O. Ayau, Korantanis, K., Pyrgakis, V., Kartsagkoulis, E., Olympios, C., Dimitra, K., Moschos, N., Daskalaki, A., Kifnidis, K., Exarchou, E., Karamitsos, C., Tziortziotis, A., Bourlios, P., Mavronasiou, E., Alexopoulos, D., Winter, K., Wolde, C., Buelow-Johansen, B., Winkelmann, B., Weyland, K., Buchholz, M., Voehringer, Voehringer, Ludwig, I., Veltkamp, R., Zarpentin, C., Taggeselle, J., Stoehring, R., Bonin, K., Spitzer, S., Baylacher, M., Sohn, H., Gold, G., Seibert, H., Hellmers, J., Schreckenberg, A., Schmidt, M., Schmidt, A., Schiewe, C., Dreykluft, K., Ellis, J., Cristaldi, J., Finsterbusch, T., Erenrich, N., Schenkenberger, I., Frommhold, R., Schellong, S., Szymanowski, N., Schaefer, A., Kuehlenborg, A., Rinke, A., Pilipenko, H., Rack, K., Kuhlmann, M., Proskynitopoulos, N., Pohl, W., Lewinsky, D., Piechatzek, R., Raddatz, K., Mueller-Glamann, M., Barbera, S., Muegge, A., Vogt, S., Mitrovic, V., Frahm, E., Meyer-Pannwitt, U., Braemer, U., Meissner, G., Hoefer, K., Maus, O., Wulf, M., Luttermann, M., Venneklaas, U., Lueders, S., Grosse, B., Lohrbaecher-Kozak, I., Bauch, F., Koenig, H., Meusel, P., Kleinecke-Pohl, U., Schoen, B., Jungmair, W., Schmid, S., Junggeburth, J., Fink, P., Horacek, T., Schuppe, M., Hoffmann, S., Dorn, S., Hoffmann, U., Dieckheuer, U., Heuer, H., Peitz, M., Hartmann, A., Otto, A., Grigat, C., Manuela, W., Fuchs, R., Schneider, K., Forck-Boedeker, K., Faghih, M., Herfurth, B., Drescher, T., Kranz, P., Degtyareva, E., Ayasse, D., Daut, W., Kara, M., Contzen, C., Weihrauch, D., Buhr, M., Ladenburger, K., Braun, R., Schnelzer, P., Bouzo, M., Sehr, B., Beyer-Westendorf, J., Vierbeck, S., Berrouschot, J., Dichristin, U., Bernhardt, P., Wurow, A., Al-Zoebi, A., Duprat, C., Roudaut, R., Leparree, S., Poulard, J., Corbut, S., Kacet, S., Deruche, E., Hermida, J., Arfaoui, M., Dinanian, S., El Jarroudi, M., Decoulx, E., Berger, N., Coisne, D., Dias, P., Blanc, J., Berbari, H., Belhassane, A., Boyer, M., Babuty, D., Boursin, P., Amarenco, P., El Jarroudi, F., Agraou, B., Le Heuzey, J., Nappila, H., Virtanen, V., Salminen, O., Rasi, H., Sankari, T., Nyman, K., Viitaniemi, J., Maenpaa, A., Laheaar, M., Lucijanic, T., Lappalainen, T., Jakala, P., Valpas, S., Hussi, E., Kaarleenkaski, S., Huikuri, H., Ratnik, E., Vahula, V., Rajasalu, R., Rosenthal, A., Voitk, J., Paumets, M., Rivis, L., Laane, E., Kolk, R., Stern, A., Kaik, J., Serup-Hansen, K., Wiggers, H., Jakobsen, U., Torp-Pedersen, C., Svenningsen, A., Sand, N., Raae, D., Raymond, I., Petrovic, V., Overgaard, K., Olsen, R., Nielsen, H., Veng-Olsen, T., Iversen, H., Madsen, H., Ibsen, H., Loof, A., Hassager, C., Christensen, L., Christensen, H., Dodt, K., Zidkova, E., Samkova, D., Vodnansky, P., Labrova, R., Spinar, J., Johnson, C., Spacek, R., Slaby, J., Reichert, P., Jirsova, E., Podrazil, P., Pisova, J., Havlova, I., Petrova, I., Peterka, K., Olsr, J., Nechanicky, R., Melichar, M., Krocova, E., Machova, V., Ludka, O., Kvasnicka, J., Kuchar, R., Kovar, P., Kosek, Z., Kostkova, G., Kochrt, M., Kobza, R., Jirmar, R., Jerabek, O., Jelinek, Z., Jarkovsky, P., Jandik, J., Hubac, J., Honkova, M., Gregor, P., Golan, L., Francek, L., Florian, J., Ferkl, R., Elbl, L., Cermak, O., O'Brien, J., Burianova, H., Brtko, M., Kunkelova, V., Berka, L., Brodova, P., Bar, M., Bergovec, M., Vrazic, H., Bakliza, Z., Sutalo, K., Kirner, D., Steiner, R., Cvitkusic Lukenda, K., Samardzic, P., Buksa, B., Knezevic, A., Jaksic Jurinjak, S., Ettinger, N., Shipp, A., Jelic, V., Makar Ausperger, K., Francetic, I., Romic, I., Ferri Certic, J., Tusek, S., Ciglenecki, N., Jeric, M., Car, S., Carevic, V., Bagatin, J., Perdomo Mejia, I., Sanchez Vallejo, G., Gonzales, C., Quintero, A., Fonseca, J., Orozco Linares, L., Lopez Giraldo, D., Moncada Corredor, M., Rivera Rodriguez, E., Manzur, F., Builes, A., Jaramillo Munoz, C., Delgado, P., Hernandez, H., Aldana Diaz, I., Fernandez Ruiz, R., Arroyave, C., Delgado Restrepo, J., Leon Pineda, L., Cano, N., Accini, M., Accini, J., Zhang, Y. L., Zhou, S. X., Li, B. G., Zheng, Z. Q., Wang, J. Q., Zhao, X. L., Han, R. J., Zhao, R. P., Kang, H., Zhang, Z., Lin, Y. N., Zhang, H. Q., Qiang, H., Everhart, B., DeSalle, D., Fahmy, R., Watkins, D., Yuan, Z. Y., Li, L. L., Yu, B., Xu, Y. P., Yin, Y. H., Gao, M., Zheng, Y., Feld, L., Zheng, X., Tameron, A., Feldman, J., Tang, N., Felten, W., Yang, Y. J., Li, A. Y., Yang, K., Liang, Y. Z., Xu, Y. M., Gu, J. Y., Xu, J. H., Li, Y. E., Wu, S. L., Huang, D., Wei, M., Shi, X. J., Wang, G. P., Qi, S. Y., Wang, D. M., Yang, Z. Y., Ma, S. M., Lu, Z. H., Liu, L., Gu, X. J., Liao, D. N., Liu, Y., Prior, J., Fialkow, J., Calvo, M., Li, Z. Q., Liu, B., Finkel, M., Shriver, D., Finkelstein, S., Fischell, T., Drew, B., Fishbein, G., Donahue, S., Flores, E., Slayton, C., Forman, S., Solis, A., Frais, M., Thrope, C., Franco, M., Gentry, P., French, W., Morales, C., Friedlander, I., Smith, K., Gaffney, M., Jones, J., Li, W. M., Kong, Y. Q., Li, T. F., Liu, H., Li, L., Qu, Z., Jiang, X. J., Qiu, Y., Hong, L., You, Z. G., Hong, K., Zhang, P., Fu, G. S., Feng, C., Dong, Y. G., Zhang, X., Chen, X. P., Xie, X. D., Chen, J. Z., Xu, G. L., Bai, F., Grandon Azua, M., Yovaniniz, P., Lara Lara, C., Stockins, B., Campisto, Y., Zapata Staub, J., Potthoff, S., Torres Carrasco, G., Pincetti, C., Carmona Perez, M., Opazo, M., Romero Llamas, R., Martinez, D., Manriquez Silva, L., Manriquez, L., Rebolledo, C., Lopetegui, M., Arratia Diaz, P., Florenzano, F., Parada, A., Corbalan, R., Obreque, C., Cobos, J., Mondaca Mondaca, P., Bugueno, C., Retamal Matus, L., Balboa, W., Mabee, J., Woodford, T., Caterini, T., Wharton, S., Morley, A., Wahby, R., Giesbrecht, L., Velthuysen, G., Teitelbaum, J., Teitelbaum, I., Tremblay, M., Talbot, P., David, D., Talajic, M., Bobbie, C., Syan, G., Kailey, P., Sussman, J., Morissette, A., St-Hilaire, R., Silverio, G., Shu, D., Marchand, C., Rupka, D., Bozek, B., Ricci, J., Nethercott, C., Qureshi, A., Turri, L., Polasek, P., Sardin, V., Pesant, Y., Carroll, L., Parkash, R., Bolton, R., O'Mahony, W., Banville, P., O'Hara, G., Nicholson, R., Lamoureux, U., Garb, J., Najarali, A., Krider, J., Mucha, M., Roth, M., Morrison, D., Morely, A., Mawji, A., Studenikow, E., Maranda, C., Vaillancourt, T., Malette, P., Matthews, J., MacCallum, C., Seib, M., Ma, P., Douglas, S., Luton, R., Roberts, P., Lichtenstein, T., Lam, H., Lam, S., St-Germain, L., Lainesse, A., Dewar, C., Labonte, R., Roy, M., Kouz, S., Perkins, L., Huynh, T., Standring, R., Hoag, G., Ho, V., Ho, K., Scott, L., Heath, J., Hatheway, R., Houbraken, D., Viau, C., Fortin, C., Zondag, M., Eikelboom, J., Dufresne, M., Kubanska, A., du Preez, M., Denis, I., Coutu, B., Masson, C., Costi, P., Gauthier, M., Constance, C., Valley, S., Cleveland, D., Vansickle, L., Chilvers, M., Lepage, C., Otis, J., Cha, J., Hundseth, M., Bose, S., Stafford, C., Bhargava, R., Antle, S., Archibald, J., Manoylov, E., Kitova, M., Tzekova, M., Tumbeva, D., Tumbev, H., Nyagina, M., Todorov, G., Momchilova-Lozeva, D., Staneva, A., Vasilev, I., Popov, A., Milusheva, T., Petranov, S., Kostov, K., Pencheva, G., Vasilev, D., Nikolov, F., Stoyanovski, V., Mincheva, V., Miteva, B., Mihov, A., Manolova, A., Kamenova, P., Hergeldjieva, V., Kinova, E., Goudev, A., Kostova, E., Georgiev, B., Gergova, V., Donova, T., Milcheva, N., Denchev, S., Parishev, G., Chompalova, B., Zimmermann, E. Burger, Zimmermann, S., Almeida, M., Boas, F. Villas, Lustosa, E., Sobral Filho, D., Carraro, A., Simoes, M., Vicente, C., Saraiva, J., do Val, R., Sampaio, R., Pagnan, L. Goncalves, dos Santos, F. Rossi, Rodrigues, D., Rodrigues, A., Rocha, M. Rubia, Rodrigues, L., Barros, R., Rocha, J., Leipelt, J., Katz Weiand, L. Reis, Avellar, K., Reis, G., Gozalo, A., Almeida, J. Pimenta, Luiz, R. Osorio, Leaes, P., Morales, K., Sebba Barroso de Souza, W. Kunz, Radaelli, G., Kalil, C., Almeida, A., Kaiser, S., Cury, C., Jorge, J., Pereira, L., Jaeger, C., Ninho, L., Guimaraes, A., Gomes, A., Gomes, M., Pereira, G., Gagliardi, R., Daitz, C., Finimundi, H., Araujo, E., Ferreira, L., Seroqui, M., Saporito, W. Faustino, Morgado, S., Dutra, O., Laimer, R., Duda, N., Pereira, V., De Patta, M., Barroso, D., Costantini, C., Silva, J., Chaves Junior, H., Fleck, N., Brondani, R., Cunha, S., Botelho, R., Sehnem, E., Precoma, D. Bertolim, Ferraz, R. Franchin, Alves da Costa, F. Augusto, Motta, C., Atie, J., de Melo, R. Ferreira, Lotufo, P. Andrade, Coutinho, E., Vincenzo de Paola, A. Amato, Denie, D., and Wollaert, B.
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Male ,medicine.medical_specialty ,medicine.drug_mechanism_of_action ,medicine.drug_class ,Pyridines ,Factor Xa Inhibitor ,Infarction ,chemistry.chemical_compound ,Double-Blind Method ,Edoxaban ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,Myocardial infarction ,cardiovascular diseases ,Stroke ,Aged ,Advanced and Specialized Nursing ,Dose-Response Relationship, Drug ,business.industry ,Anticoagulant ,Warfarin ,Anticoagulants ,Atrial fibrillation ,Middle Aged ,medicine.disease ,Thiazoles ,Treatment Outcome ,chemistry ,Anesthesia ,Cardiology ,Female ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
Background and Purpose— The once-daily oral factor Xa inhibitor, edoxaban, is as effective as warfarin in preventing stroke and systemic embolism while decreasing bleeding in a phase III trial of patients with atrial fibrillation at moderate–high stroke risk. Limited data regarding cerebrovascular events with edoxaban were reported previously. Methods— We analyzed the subtypes of cerebrovascular events in 21 105 patients participating in Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48 (ENGAGE AF-TIMI 48) comparing outcomes among patients randomized to warfarin versus 2 edoxaban regimens (high dose, low dose). The primary end point for this prespecified analysis of cerebrovascular events was all stroke (ischemic plus hemorrhagic), defined as an abrupt onset of focal neurological deficit because of infarction or bleeding with symptoms lasting ≥24 hours or fatal in Results— Patients randomized to high-dose edoxaban had fewer strokes on-treatment (hazard ratio, 0.80; 95% confidence interval, 0.65–0.98) than warfarin (median time-in-therapeutic range, 68.4%); patients in the low-dose edoxaban group had similar rates (hazard ratio, 1.10 versus warfarin; 95% confidence interval, 0.91–1.32). Rates of ischemic stroke or transient ischemic attack were similar with high-dose edoxaban (1.76% per year) and warfarin (1.73% per year; P =0.81), but more frequent with low-dose edoxaban (2.48% per year; P Conclusions— In patients with atrial fibrillation, once-daily edoxaban was as effective as warfarin in preventing all strokes, with significant reductions in various subtypes of intracranial bleeding. Ischemic cerebrovascular event rates were similar with high-dose edoxaban and warfarin, whereas low-dose edoxaban was less effective than warfarin. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00781391.
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- 2014
13. P.1.b.009 Suicide attempts are associated with hippocampal volumes in depressed patients, independently from previous antidepressant treatments
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Colle, R., primary, Chupin, M., additional, Cury, C., additional, Vandendries, C., additional, Gressier, F., additional, Hardy, P., additional, Falissard, B., additional, Colliot, O., additional, Ducreux, D., additional, and Corruble, E., additional
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- 2015
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14. ENXAGUATÓRIO BUCAL: PRINCIPAIS ATIVOS E DESENVOLVIMENTO DE FÓRMULA CONTENDO EXTRATO HIDROALCOÓLICO DE Salvia officinalis L.
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ZANIN, Sandra Maria Warumby, primary, MIGUEL, Marilis Dallarmi, additional, BARREIRA, Sandra Maria W., additional, NAKASHIMA, T., additional, CURY, C. D., additional, and COSTA, Camila Cloker, additional
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- 2007
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15. Caracterização clínica dos cães diabéticos atendidos no Hovet Unisa
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Cury, C. M., primary and Jericó, M. M., primary
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- 2003
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16. Excreção urinaria de sodio e risco de morte em portadores de doença renal cronica não dialitica.
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Malheiro Cury, C., Burgugi Banin, V., Mineto Brabo, A., Carvalho de Oliveira, R., Costa, N. A., and Cuadrado Martins, L.
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- 2017
17. Hommes au volant, femmes au volant. L'influence des stéréotypes de sexe sur les comportements de conduite déclarés et effectifs
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PRAVOSSOUDOVITCH, Karyn, Cadic, Ifsttar, Laboratoire Mécanismes d'Accidents (IFSTTAR/TS2/LMA), Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR), Aix Marseille Université, and M.A. Granié, F. Cury, C. Martha
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GENDER IDENTITY ,AUTO EVALUATION ,[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior ,[SDV.NEU.PC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior ,DRIVING BEHAVIOUR ,COMPORTEMENT DU CONDUCTEUR ,DRIVING ,COMPORTEMENT ,SEX STEREOTYPES ASSOCIATED WITH DRIVING ,[SHS.GENRE] Humanities and Social Sciences/Gender studies ,STEREOTYPE THREAT ,GENRE ,CONDUITE (VEH) ,FEMME ,EVALUATION ,STEREOTYPE ,[SCCO.PSYC]Cognitive science/Psychology ,SENSE OF COMPETENCE AS A DRIVER ,APTITUDE A LA CONDUITE ,[SCCO.PSYC] Cognitive science/Psychology ,CONDUITE DU VEHICULE ,SEX ,[SHS.GENRE]Humanities and Social Sciences/Gender studies ,HOMME ,SOCIOLOGIE - Abstract
The activity of driving is marked by numerous sex differences, especially with regard to behaviour and road accidents. The present doctoral research aims at understanding the role of sex stereotypes specific to driving in explaining these differences. Therefore, the objective of the research work is to analyse the impact of sex stereotypes associated with driving (SSAD) on self-reported or actual behaviour on a task relating to driving. The analysis will take into account the psycho-social factors likely to influence this impact, and will also study the impact of the context on those relationships due to the deterrent effect of the stereotype. This doctoral work thus shows that adherence to SSAD has an impact on self-reported driving behaviour; for example, whatever the sex, adherence to SSAD associated to sex is linked to more frequent reporting of typical driving behaviour for this sex. Moreover, the research highlights the fact that the protective factor of violation behaviour is, among men, the adoption of feminine values, and, among women, a sense of competence as a driver. Finally, this research work shows that those stereotypes come into play in actual behaviour when it comes down to carrynig out a task relating to driving, but that the effects are different depending on the instructions (whether threatening or not) and the tasks to be carried out. As a conclusion, this doctoral research indicates that the different driving behaviours are not only due to differences in sex natural abilities, but they can also be explained by socially constructed cultural beliefs relating to driving sex differences., La conduite automobile est une activité marquée par de nombreuses différences de sexe, notamment en termes de comportements et d'accidentologie. Ce travail doctoral cherche à comprendre le rôle des stéréotypes de sexe spécifiques à la conduite automobile dans l'explication de ces différences. L'objectif des recherches est ainsi d'analyser l'effet des stéréotypes de sexe associés à la conduite automobile (SSACA) sur les comportements autorapportés et effectifs reliés à la tâche de conduite, d'une part en prenant en compte les facteurs psychosociaux susceptibles d'influencer cet effet, et d'autre part en étudiant l'effet du contexte sur ces relations grâce à l'effet de menace du stéréotype. Cette thèse montre ainsi que l'adhésion aux SSACA influence les comportements de conduite déclarés puisque, par exemple, quel que soit le sexe de l'individu, l'adhésion aux SSACA liés à un groupe de sexe est liée à une déclaration plus importante des comportements de conduite typiques de ce groupe. De plus, cette thèse met en évidence que le facteur protecteur des comportements de violations est, chez les hommes, l'adoption des valeurs féminines et, chez les femmes, le sentiment de compétence en conduite. Enfin, cette thèse montre que ces stéréotypes entrent également en jeu dans les comportements effectifs lorsqu'il s'agit de réaliser une tâche en relation avec la conduite automobile, mais que leurs effets sont différents en fonction à la fois de la consigne (menaçante ou non) et de la tâche à réaliser. En conclusion, ce travail doctoral montre que les différents comportements de conduite ne sont pas seulement dus à des différences de capacités naturelles entre les sexes, mais qu'ils peuvent aussi s'expliquer par les croyances culturelles socialement construites relatives aux différences de sexe dans la conduite automobile.
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- 2016
18. Management of obesity in an individual with ROHHAD syndrome with semaglutide 2.4 mg/week: a case report.
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Bonnet JB, Ramillon-Cury C, Tournayre S, Sultan A, and Avignon A
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- 2024
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19. Automatic rating of incomplete hippocampal inversions evaluated across multiple cohorts.
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Hemforth L, Couvy-Duchesne B, De Matos K, Brianceau C, Joulot M, Banaschewski T, Bokde ALW, Desrivières S, Flor H, Grigis A, Garavan H, Gowland P, Heinz A, Brühl R, Martinot JL, Paillère Martinot ML, Artiges E, Papadopoulos D, Lemaitre H, Paus T, Poustka L, Hohman S, Holz N, Fröhner JH, Smolka MN, Vaidya N, Walter H, Whelan R, Schumann G, Büchel C, Poline JB, Itterman B, Frouin V, Martin A, Cury C, and Colliot O
- Abstract
Incomplete Hippocampal Inversion (IHI), sometimes called hippocampal malrotation, is an atypical anatomical pattern of the hippocampus found in about 20% of the general population. IHI can be visually assessed on coronal slices of T1 weighted MR images, using a composite score that combines four anatomical criteria. IHI has been associated with several brain disorders (epilepsy, schizophrenia). However, these studies were based on small samples. Furthermore, the factors (genetic or environmental) that contribute to the genesis of IHI are largely unknown. Large-scale studies are thus needed to further understand IHI and their potential relationships to neurological and psychiatric disorders. However, visual evaluation is long and tedious, justifying the need for an automatic method. In this paper, we propose, for the first time, to automatically rate IHI. We proceed by predicting four anatomical criteria, which are then summed up to form the IHI score, providing the advantage of an interpretable score. We provided an extensive experimental investigation of different machine learning methods and training strategies. We performed automatic rating using a variety of deep learning models ("conv5-FC3", ResNet and "SECNN") as well as a ridge regression. We studied the generalization of our models using different cohorts and performed multi-cohort learning. We relied on a large population of 2,008 participants from the IMAGEN study, 993 and 403 participants from the QTIM and QTAB studies as well as 985 subjects from the UKBiobank. We showed that deep learning models outperformed a ridge regression. We demonstrated that the performances of the "conv5-FC3" network were at least as good as more complex networks while maintaining a low complexity and computation time. We showed that training on a single cohort may lack in variability while training on several cohorts improves generalization (acceptable performances on all tested cohorts including some that are not included in training). The trained models will be made publicly available should the manuscript be accepted., Competing Interests: 6.3.1Disclosure statement Competing financial interests related to the present article: none to disclose for all authors. Competing financial interests unrelated to the present article: OC reports having received consulting fees from AskBio (2020) and Therapanacea (2022–2024), and that his laboratory has received grants (paid to the institution) from Qynapse (2017–2022). Members from his laboratory have co-supervised a PhD thesis with Qynapse (2017–2022). OC’s spouse was an employee of myBrainTechnologies and is an employee of DiamPark. OC holds a patent registered at the International Bureau of the World Intellectual Property Organization (PCT/IB2016/0526993, Schiratti J-B, Allassonniere S, Colliot O, Durrleman S, A method for determining the temporal progression of a biological phenomenon and associated methods and devices) (2017). Tobias Banaschewski served in an advisory or consultancy role for eye level, Infectopharm, Lundbeck, Medice, Neurim Pharmaceuticals, Oberberg GmbH, Roche, and Takeda. He received conference support or speaker’s fee by Janssen, Medice and Takeda. He received royalities from Hogrefe, Kohlhammer, CIP Medien, Oxford University Press; the present work is unrelated to these relationships. Dr. Barker has received honoraria from General Electric Healthcare for teaching on scanner programming courses. Dr. Poustka served in an advisory or consultancy role for Roche and Viforpharm and received speaker’s fee by Shire. She received royalties from Hogrefe, Kohlhammer and Schattauer. The present work is unrelated to the above grants and relationships.The other authors report no biomedical financial interests or potential conflicts of interest.
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- 2024
20. Outcome of early versus delayed presentation of proximal femur fractures in children: A prospective cohort study.
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Regmi A, Singh V, Bandhu Niraula B, Gowda AKS, Bansal S, Gowda R, Sharma C, and Barman S
- Subjects
- Humans, Child, Male, Female, Prospective Studies, Adolescent, Child, Preschool, Time-to-Treatment, Treatment Outcome, Time Factors, Femoral Fractures surgery, Femoral Fractures diagnostic imaging, Proximal Femoral Fractures, Fracture Fixation, Internal methods
- Abstract
Objective: We hypothesized that the exact time of fixation of paediatric proximal femur fractures will have an effect on the ultimate clinical and radiological outcome. This article aimed to compare the clinical-radiological outcomes in paediatric proximal femur fractures having early and delayed presentation., Methodology: A prospective cohort study was conducted from January 2019 to November 2022 in patients of age of 5 to 16 years presented with proximal femur fracture and divided into two groups: group A: early presentation, presented <48hours of injury; group B: delayed presentation, presented >48hours of injury. Patients underwent internal fixation treatment modality and followed up to assess clinical outcomes and radiological outcomes, and final outcome was assessed as per Ratliff's criteria., Results: In the study of 44 patients, 72.72% were male, and 27.27% were female, with male-to-female ratio to be 2.6:1. The commonest mode of injury was fall from height accounting for 52.27% followed by road traffic accidents (RTA) in 38.63%. The most common fracture type observed was Delbet type II, which was observed in 43.18%. There was significant shorter duration of surgery in group A (p-value=0.013), VAS score (p=0.045), and limb length discrepancy (p=0.022). Also, there was a statistical difference in AVN (p-value=0.0295) and growth disturbance (p-value=0.0394) between two groups. Also, there was statistically significant difference between Ratliff's criteria two groups (p-value=0.030)., Conclusion: Early presentation has shorter duration of surgery, less VAS score at final follow-up, and less limb length discrepancy, less development of complications like avascular necrosis of the femoral head, and growth disturbance., Level of Evidence: III., (Copyright © 2024. Published by Elsevier Masson SAS.)
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- 2024
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21. Medial positioning of the hippocampus and hippocampal fissure volume in developmental topographical disorientation.
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Fragueiro A, Cury C, Santacroce F, Burles F, Iaria G, and Committeri G
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- Humans, Brain, Hippocampus diagnostic imaging, Temporal Lobe, Magnetic Resonance Imaging, Confusion
- Abstract
Developmental topographical disorientation (DTD) refers to the lifelong inability to orient by means of cognitive maps in familiar surroundings despite otherwise well-preserved general cognitive functions, and the absence of any acquired brain injury or neurological condition. While reduced functional connectivity between the hippocampus and other brain regions has been reported in DTD individuals, no structural differences in gray matter tissue for the whole brain neither for the hippocampus were detected. Considering that the human hippocampus is the main structure associated with cognitive map-based navigation, here, we investigated differences in morphological and morphometric hippocampal features between individuals affected by DTD (N = 20) and healthy controls (N = 238). Specifically, we focused on a developmental anomaly of the hippocampus that is characterized by the incomplete infolding of hippocampal subfields during fetal development, giving the hippocampus a more round or pyramidal shape, called incomplete hippocampal inversion (IHI). We rated IHI according to standard criteria and extracted hippocampal subfield volumes after FreeSurfer's automatic segmentation. We observed similar IHI prevalence in the group of individuals with DTD with respect to the control population. Neither differences in whole hippocampal nor major hippocampal subfield volumes have been observed between groups. However, when assessing the IHI independent criteria, we observed that the hippocampus in the DTD group is more medially positioned comparing to the control group. In addition, we observed bigger hippocampal fissure volume for the DTD comparing to the control group. Both of these findings were stronger for the right hippocampus comparing to the left. Our results provide new insights regarding the hippocampal morphology of individuals affected by DTD, highlighting the role of structural anomalies during early prenatal development in line with the developmental nature of the spatial disorientation deficit., (© 2024 Wiley Periodicals LLC.)
- Published
- 2024
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22. Outcomes of a single dose of injection polidocanol application in aneurysmal bone cyst.
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Sharma C, Barman S, Bansal S, Panda D, Pranav J, Maheshwari V, and Dhingra M
- Abstract
Background: Aneurysmal bone cysts are common osteolytic tumours that have ability to expand and produce pathological fractures. Recurrence is a major issue in such tumours posing a treatment dilemma to clinicians. Injection polidocanol has shown promising results, but the number of injections still remains a topic of debate., Methodology: A prospective interventional study done on 13 patients of biopsy-proven aneurysmal bone cysts. Patient related outcome measures(PROM's) seen using VAS score, SF-12 score and ROM of the involved extremity. Radiologically volume of tumour and cortico-medullary ratio were calculated. All patients received single dose of injection polidocanol and were followed up to 6 months., Results: The mean age of patients was 9.5 years, with slight female predominance. Most cases had Campana grade 1. Mean VAS score improved from 9/10 to 1/10, ROM of the proximal and distal joints of the involved bone improved from 60 % (± 20 %) to 100 %. Mean SF12 score increased from 41 (±7): 47 (±3) to 54 (±2): 58 (±2) at the end of 6 months(p < 0.05).Mean volume of the lesion decreased from 6.30 cc (± 1.30) to 2.86 cc (±1.34) (p < 0.0005) with a reduction of MCR from 4.8 (±0.6) to 3.6 (±0.5) on a similar time span (p < 0.0005) at end of 6 months. 2 patients showed recurrence with none of the patients showing any complication., Conclusion: Single dose of Injection Polidocanol for Aneurysmal Bone Cysts is a unique study, not described in literature before. The smaller lesion in initial staging can be treated effectively with single dose of polidocanol reducing morbidity and treatment cost to the patient. It is as good as giving multiple doses of Polidocanol as per as functionality of the limb is concerned.Also, we propose a new parameter "Medullary-cortical ratio", which is an effective way to assess the improvement and resolution of ABC after administration of Polidocanol., Competing Interests: No conflict of interest was declared among the authors., (© 2023 Professor P K Surendran Memorial Education Foundation. Published by Elsevier B.V. All rights reserved.)
- Published
- 2023
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23. Temporo-basal sulcal connections: a manual annotation protocol and an investigation of sexual dimorphism and heritability.
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de Matos K, Cury C, Chougar L, Strike LT, Rolland T, Riche M, Hemforth L, Martin A, Banaschewski T, Bokde ALW, Desrivières S, Flor H, Grigis A, Garavan H, Gowland P, Heinz A, Brühl R, Martinot JL, Paillère Martinot ML, Artiges E, Nees F, Papadopoulos Orfanos D, Lemaitre H, Paus T, Poustka L, Hohmann S, Millenet S, Fröhner JH, Smolka MN, Vaidya N, Walter H, Whelan R, Schumann G, Frouin V, Bach Cuadra M, Colliot O, and Couvy-Duchesne B
- Subjects
- Male, Female, Humans, Magnetic Resonance Imaging, Hippocampus, Functional Laterality genetics, Sex Characteristics, Temporal Lobe diagnostic imaging
- Abstract
The temporo-basal region of the human brain is composed of the collateral, the occipito-temporal, and the rhinal sulci. We manually rated (using a novel protocol) the connections between rhinal/collateral (RS-CS), collateral/occipito-temporal (CS-OTS) and rhinal/occipito-temporal (RS-OTS) sulci, using the MRI of nearly 3400 individuals including around 1000 twins. We reported both the associations between sulcal polymorphisms as well with a wide range of demographics (e.g. age, sex, handedness). Finally, we also estimated the heritability, and the genetic correlation between sulcal connections. We reported the frequency of the sulcal connections in the general population, which were hemisphere dependent. We found a sexual dimorphism of the connections, especially marked in the right hemisphere, with a CS-OTS connection more frequent in females (approximately 35-40% versus 20-25% in males) and an RS-CS connection more common in males (approximately 40-45% versus 25-30% in females). We confirmed associations between sulcal connections and characteristics of incomplete hippocampal inversion (IHI). We estimated the broad sense heritability to be 0.28-0.45 for RS-CS and CS-OTS connections, with hints of dominant contribution for the RS-CS connection. The connections appeared to share some of their genetic causing factors as indicated by strong genetic correlations. Heritability appeared much smaller for the (rarer) RS-OTS connection., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2023
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24. Comparison of clinical with CT based evaluation for tibial torsion.
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Singh H, Gupta P, Kaur R, and Sharma C
- Abstract
Purpose: Tibial torsion is important to be factored in during calculations of angular deformities of the lower extremity. Three methods are commonly used, thigh foot angle, measurement of transmalleolar axis with proximal tibia or knee as a reference, and Computerized tomography. The purpose of the current study was to find out the effectiveness of clinical methods and compare CT based method for tibial torsion., Methods: A total of 68 limbs (34 subjects) were included. Tibial torsion was measured using thigh foot angle, transmalleolar axis in relation to knee forward position (Knee ankle axis) and CT based evaluation using Jend method., Results: Pearson correlation coefficient showed strong correlation between CT values and thigh foot angle (r = 0.848) as well as between CT values and Knee ankle axis (r = 0.889). Scatter plots also showed a linear distribution., Conclusion: Both thigh foot angle and Knee ankle axis provide reliable alternative to ionizing CT in measuring tibial torsion., Competing Interests: Nil., (© 2022 Delhi Orthopedic Association. All rights reserved.)
- Published
- 2022
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25. SGLT2 inhibitors as potentially helpful drugs in PI3K inhibitor-induced diabetes: a case report.
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Sahakian N, Cattieuw L, Ramillon-Cury C, Corroller AB, Silvestre-Aillaud P, Béliard S, and Valéro R
- Abstract
Background: Hyperglycemia is the most common side-effect of phosphatidylinositol 3-kinase (PI3K) inhibitors that are approved for the treatment of some advanced or metastatic breast cancers. This side-effect is likely due to the central role of PI3K in insulin signalling. Here we report the use of a sodium-glucose cotransporter 2 (SGLT2) inhibitor to manage severe hyperglycemia., Case Presentation: We describe a 74-year-old woman who developed severe uncontrolled hyperglycemia after commencing alpelisib, a new oral PI3K inhibitor indicated for a metastatic breast cancer, despite taking oral anti-diabetic drugs, metformin and vildagliptin, combined with intravenous insulin infusion of up to 250 units/day. The introduction of the SGLT2 inhibitor dapagliflozin rapidly improved blood glucose with a drastic reduction in insulin dosage, from 250 to 12 units/day, and without significant side-effects., Conclusions: We report the successful management of hyperglycemia induced by alpelisib using a SGLT2 inhibitor without the need to discontinue effective cancer treatment., (© 2021. The Author(s).)
- Published
- 2021
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26. A Diffeomorphic Vector Field Approach to Analyze the Thickness of the Hippocampus From 7 T MRI.
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Guyot A, Fouquier ABG, Gerardin E, Chupin M, Glaunes JA, Marrakchi-Kacem L, Germain J, Boutet C, Cury C, Hertz-Pannier L, Vignaud A, Durrleman S, Henry TR, van de Moortele PF, Trouve A, and Colliot O
- Subjects
- Atrophy pathology, Humans, Magnetic Resonance Imaging, Seizures, Epilepsy, Temporal Lobe diagnostic imaging, Hippocampus diagnostic imaging
- Abstract
Objective: 7-Tesla MRI of the hippocampus enhances the visualization of its internal substructures. Among these substructures, the cornu Ammonis and subiculum form a contiguous folded ribbon of gray matter. Here, we propose a method to analyze local thickness measurements of this ribbon., Methods: We introduce an original approach based upon the estimation of a diffeomorphic vector field that traverses the ribbon. The method is designed to handle specificities of the hippocampus and corresponding 7-Tesla acquisitions: highly convoluted surface, non-closed ribbon, incompletely defined inner/outer boundaries, anisotropic acquisitions. We furthermore propose to conduct group comparisons using a population template built from the central surfaces of individual subjects., Results: We first assessed the robustness of our approach to anisotropy, as well as to inter-rater variability, on a post-mortem scan and on in vivo acquisitions respectively. We then conducted a group study on a dataset of in vivo MRI from temporal lobe epilepsy (TLE) patients and healthy controls. The method detected local thinning patterns in patients, predominantly ipsilaterally to the seizure focus, which is consistent with medical knowledge., Conclusion: This new technique allows measuring the thickness of the hippocampus from 7-Tesla MRI. It shows good robustness with respect to anisotropy and inter-rater variability and has the potential to detect local atrophy in patients., Significance: As 7-Tesla MRI is increasingly available, this new method may become a useful tool to study local alterations of the hippocampus in brain disorders. It is made freely available to the community (code: https://github.com/aramis-lab/hiplay7-thickness, postmortem segmentation: https://doi.org/10.5281/zenodo.3533264).
- Published
- 2021
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27. P036 Clinical and Psychological Factors Associated with Impaired Body Image in Patients with Inflammatory Bowel Disease.
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Clara U, Amanda T, Debora T, Giovana C, Jaqueline B, Julio B, Rogerio SH, and Ligia S
- Published
- 2020
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28. P041 Morbidity Due to IBD and its Influence on Health-Related Quality of Life and Virtual Social Interaction Through Facebook.
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Giovana C, Debora T, Amanda T, Giedre H, Jaqueline B, Julio B, Rogerio SH, Ligia S, and Clara U
- Published
- 2020
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29. Hippocampal Shape Is Associated with Memory Deficits in Temporal Lobe Epilepsy.
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Postma TS, Cury C, Baxendale S, Thompson PJ, Cano-López I, de Tisi J, Burdett JL, Sidhu MK, Caciagli L, Winston GP, Vos SB, Thom M, Duncan JS, Koepp MJ, and Galovic M
- Subjects
- Adult, Brain Mapping, Epilepsy, Temporal Lobe complications, Female, Humans, Magnetic Resonance Imaging, Male, Memory Disorders etiology, Middle Aged, Neuropsychological Tests, Organ Size physiology, Epilepsy, Temporal Lobe diagnostic imaging, Hippocampus diagnostic imaging, Memory Disorders diagnostic imaging, Memory, Episodic
- Abstract
Objective: Cognitive problems, especially disturbances in episodic memory, and hippocampal sclerosis are common in temporal lobe epilepsy (TLE), but little is known about the relationship of hippocampal morphology with memory. We aimed to relate hippocampal surface-shape patterns to verbal and visual learning., Methods: We analyzed hippocampal surface shapes on high-resolution magnetic resonance images and the Adult Memory and Information Processing Battery in 145 unilateral refractory TLE patients undergoing epilepsy surgery, a validation set of 55 unilateral refractory TLE patients, and 39 age- and sex-matched healthy volunteers., Results: Both left TLE (LTLE) and right TLE (RTLE) patients had lower verbal (LTLE 44 ± 11; RTLE 45 ± 10) and visual learning (LTLE 34 ± 8, RTLE 30 ± 8) scores than healthy controls (verbal 58 ± 8, visual 39 ± 6; p < 0.001). Verbal learning was more impaired the greater the atrophy of the left superolateral hippocampal head. In contrast, visual memory was worse with greater bilateral inferomedial hippocampal atrophy. Postsurgical verbal memory decline was more common in LTLE than in RTLE (reliable change index in LTLE 27% vs RTLE 7%, p = 0.006), whereas there were no differences in postsurgical visual memory decline between those groups. Preoperative atrophy of the left hippocampal tail predicted postsurgical verbal memory decline., Interpretation: Memory deficits in TLE are associated with specific morphological alterations of the hippocampus, which could help stratify TLE patients into those at high versus low risk of presurgical or postsurgical memory deficits. This knowledge could improve planning and prognosis of selective epilepsy surgery and neuropsychological counseling in TLE. ANN NEUROL 2020 ANN NEUROL 2020;88:170-182., (© 2020 The Authors. Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association.)
- Published
- 2020
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30. Simultaneous EEG-fMRI during a neurofeedback task, a brain imaging dataset for multimodal data integration.
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Lioi G, Cury C, Perronnet L, Mano M, Bannier E, Lécuyer A, and Barillot C
- Subjects
- Healthy Volunteers, Humans, Brain Mapping, Electroencephalography, Magnetic Resonance Imaging, Neurofeedback
- Abstract
Combining EEG and fMRI allows for integration of fine spatial and accurate temporal resolution yet presents numerous challenges, noticeably if performed in real-time to implement a Neurofeedback (NF) loop. Here we describe a multimodal dataset of EEG and fMRI acquired simultaneously during a motor imagery NF task, supplemented with MRI structural data. The study involved 30 healthy volunteers undergoing five training sessions. We showed the potential and merit of simultaneous EEG-fMRI NF in previous work. Here we illustrate the type of information that can be extracted from this dataset and show its potential use. This represents one of the first simultaneous recording of EEG and fMRI for NF and here we present the first open access bi-modal NF dataset integrating EEG and fMRI. We believe that it will be a valuable tool to (1) advance and test methodologies for multi-modal data integration, (2) improve the quality of NF provided, (3) improve methodologies for de-noising EEG acquired under MRI and (4) investigate the neuromarkers of motor-imagery using multi-modal information.
- Published
- 2020
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31. Deviations in early hippocampus development contribute to visual hallucinations in schizophrenia.
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Cachia A, Cury C, Brunelin J, Plaze M, Delmaire C, Oppenheim C, Medjkane F, Thomas P, and Jardri R
- Subjects
- Hallucinations, Hippocampus, Humans, Temporal Lobe, Schizophrenia complications
- Abstract
Auditory hallucinations (AHs) are certainly the most emblematic experiences in schizophrenia, but visual hallucinations (VHs) are also commonly observed in this developmental psychiatric disorder. Notably, several studies have suggested a possible relationship between the clinical variability in hallucinations' phenomenology and differences in brain development/maturation. In schizophrenia, impairments of the hippocampus, a medial temporal structure involved in mnesic and neuroplastic processes, have been repeatedly associated with hallucinations, particularly in the visual modality. However, the possible neurodevelopmental origin of hippocampal impairments in VHs has never been directly investigated. A classic marker of early atypical hippocampal development is incomplete hippocampal inversion (IHI). In this study, we compared IHI patterns in healthy volunteers, and two subgroups of carefully selected schizophrenia patients experiencing frequent hallucinations: (a) those with pure AHs and (b) those with audio-visual hallucinations (A+VH). We found that VHs were associated with a specific IHI pattern. Schizophrenia patients with A+VH exhibited flatter left hippocampi than patients with pure AHs or healthy controls. This result first confirms that the greater clinical impairment observed in A+VH patients may relate to an increased neurodevelopmental weight in this subpopulation. More importantly, these findings bring crucial hints to better specify the sensitivity period of A+VH-related IHI during early brain development.
- Published
- 2020
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32. A Sparse EEG-Informed fMRI Model for Hybrid EEG-fMRI Neurofeedback Prediction.
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Cury C, Maurel P, Gribonval R, and Barillot C
- Abstract
Measures of brain activity through functional magnetic resonance imaging (fMRI) or electroencephalography (EEG), two complementary modalities, are ground solutions in the context of neurofeedback (NF) mechanisms for brain rehabilitation protocols. While NF-EEG (in which real-time neurofeedback scores are computed from EEG signals) has been explored for a very long time, NF-fMRI (in which real-time neurofeedback scores are computed from fMRI signals) appeared more recently and provides more robust results and more specific brain training. Using fMRI and EEG simultaneously for bi-modal neurofeedback sessions (NF-EEG-fMRI, in which real-time neurofeedback scores are computed from fMRI and EEG) is very promising for the design of brain rehabilitation protocols. However, fMRI is cumbersome and more exhausting for patients. The original contribution of this paper concerns the prediction of bi-modal NF scores from EEG recordings only, using a training phase where EEG signals as well as the NF-EEG and NF-fMRI scores are available. We propose a sparse regression model able to exploit EEG only to predict NF-fMRI or NF-EEG-fMRI in motor imagery tasks. We compared different NF-predictors stemming from the proposed model. We showed that predicting NF-fMRI scores from EEG signals adds information to NF-EEG scores and significantly improves the correlation with bi-modal NF sessions compared to classical NF-EEG scores., (Copyright © 2020 Cury, Maurel, Gribonval and Barillot.)
- Published
- 2020
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33. Genome wide association study of incomplete hippocampal inversion in adolescents.
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Cury C, Scelsi MA, Toro R, Frouin V, Artiges E, Grigis A, Heinz A, Lemaître H, Martinot JL, Poline JB, Smolka MN, Walter H, Schumann G, Altmann A, and Colliot O
- Subjects
- Adolescent, Aquaporin 4 genetics, Brain Diseases diagnostic imaging, Brain Diseases physiopathology, Co-Repressor Proteins genetics, Female, Hippocampus diagnostic imaging, Humans, Male, Polymorphism, Single Nucleotide genetics, Temporal Lobe physiopathology, Brain Diseases genetics, Genetic Predisposition to Disease, Genome-Wide Association Study, Hippocampus physiopathology
- Abstract
Incomplete hippocampal inversion (IHI), also called hippocampal malrotation, is an atypical presentation of the hippocampus present in about 20% of healthy individuals. Here we conducted the first genome-wide association study (GWAS) in IHI to elucidate the genetic underpinnings that may contribute to the incomplete inversion during brain development. A total of 1381 subjects contributed to the discovery cohort obtained from the IMAGEN database. The incidence rate of IHI was 26.1%. Loci with P<1e-5 were followed up in a validation cohort comprising 161 subjects from the PING study. Summary statistics from the discovery cohort were used to compute IHI heritability as well as genetic correlations with other traits. A locus on 18q11.2 (rs9952569; OR = 1.999; Z = 5.502; P = 3.755e-8) showed a significant association with the presence of IHI. A functional annotation of the locus implicated genes AQP4 and KCTD1. However, neither this locus nor the other 16 suggestive loci reached a significant p-value in the validation cohort. The h2 estimate was 0.54 (sd: 0.30) and was significant (Z = 1.8; P = 0.036). The top three genetic correlations of IHI were with traits representing either intelligence or education attainment and reached nominal P< = 0.013., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2020
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34. Pyelolithotomy in a Patient with Complete Coraliform Calcification Induced by a Double-J Ureteral Stent.
- Author
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Bonfitto M, de Oliveira Cury A, Caroline Pagelkopf V, Ramos Bezerra de Morais V, and Abib Cury C
- Abstract
The placement of a double-J ureteral stent enables the treatment of upper urinary tract obstruction. Despite advances, forgetting the stent favors the occurrence of calcification, leading to increased morbidity rates, lawsuits, and a financial burden on the healthcare system. This paper describes a successful pyelolithotomy for the removal of a calcified double-J ureteral stent.
- Published
- 2019
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35. Spatiotemporal analysis for detection of pre-symptomatic shape changes in neurodegenerative diseases: Initial application to the GENFI cohort.
- Author
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Cury C, Durrleman S, Cash DM, Lorenzi M, Nicholas JM, Bocchetta M, van Swieten JC, Borroni B, Galimberti D, Masellis M, Tartaglia MC, Rowe JB, Graff C, Tagliavini F, Frisoni GB, Laforce R Jr, Finger E, de Mendonça A, Sorbi S, Ourselin S, Rohrer JD, and Modat M
- Subjects
- Cohort Studies, Female, Humans, Male, Middle Aged, Frontotemporal Dementia diagnostic imaging, Frontotemporal Dementia pathology, Magnetic Resonance Imaging methods, Neuroimaging methods, Prodromal Symptoms, Spatio-Temporal Analysis, Thalamus diagnostic imaging, Thalamus pathology
- Abstract
Brain atrophy as measured from structural MR images, is one of the primary imaging biomarkers used to track neurodegenerative disease progression. In diseases such as frontotemporal dementia or Alzheimer's disease, atrophy can be observed in key brain structures years before any clinical symptoms are present. Atrophy is most commonly captured as volume change of key structures and the shape changes of these structures are typically not analysed despite being potentially more sensitive than summary volume statistics over the entire structure. In this paper we propose a spatiotemporal analysis pipeline based on Large Diffeomorphic Deformation Metric Mapping (LDDMM) to detect shape changes from volumetric MRI scans. We applied our framework to a cohort of individuals with genetic variants of frontotemporal dementia and healthy controls from the Genetic FTD Initiative (GENFI) study. Our method, take full advantage of the LDDMM framework, and relies on the creation of a population specific average spatiotemporal trajectory of a relevant brain structure of interest, the thalamus in our case. The residuals from each patient data to the average spatiotemporal trajectory are then clustered and studied to assess when presymptomatic mutation carriers differ from healthy control subjects. We found statistical differences in shape in the anterior region of the thalamus at least five years before the mutation carrier subjects develop any clinical symptoms. This region of the thalamus has been shown to be predominantly connected to the frontal lobe, consistent with the pattern of cortical atrophy seen in the disease., (Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2019
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36. Statistical Shape Analysis of Large Datasets Based on Diffeomorphic Iterative Centroids.
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Cury C, Glaunès JA, Toro R, Chupin M, Schumann G, Frouin V, Poline JB, and Colliot O
- Abstract
In this paper, we propose an approach for template-based shape analysis of large datasets, using diffeomorphic centroids as atlas shapes. Diffeomorphic centroid methods fit in the Large Deformation Diffeomorphic Metric Mapping (LDDMM) framework and use kernel metrics on currents to quantify surface dissimilarities. The statistical analysis is based on a Kernel Principal Component Analysis (Kernel PCA) performed on the set of initial momentum vectors which parametrize the deformations. We tested the approach on different datasets of hippocampal shapes extracted from brain magnetic resonance imaging (MRI), compared three different centroid methods and a variational template estimation. The largest dataset is composed of 1,000 surfaces, and we are able to analyse this dataset in 26 h using a diffeomorphic centroid. Our experiments demonstrate that computing diffeomorphic centroids in place of standard variational templates leads to similar shape analysis results and saves around 70% of computation time. Furthermore, the approach is able to adequately capture the variability of hippocampal shapes with a reasonable number of dimensions, and to predict anatomical features of the hippocampus, only present in 17% of the population, in healthy subjects.
- Published
- 2018
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37. Hippocampal volume predicts antidepressant efficacy in depressed patients without incomplete hippocampal inversion.
- Author
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Colle R, Cury C, Chupin M, Deflesselle E, Hardy P, Nasser G, Falissard B, Ducreux D, Colliot O, and Corruble E
- Subjects
- Adolescent, Adult, Aged, Antidepressive Agents therapeutic use, Case-Control Studies, Depressive Disorder, Major drug therapy, Female, Hippocampus diagnostic imaging, Hippocampus drug effects, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Psychiatric Status Rating Scales, ROC Curve, Young Adult, Depressive Disorder, Major diagnostic imaging, Depressive Disorder, Major pathology, Hippocampus pathology
- Abstract
Background: Incomplete hippocampal inversion (IHI), also called malrotation, is a frequent atypical anatomical pattern of the hippocampus. Because of the crucial implication of the hippocampus in Major Depressive Disorder (MDD) and the neurodevelopmental hypothesis of MDD, we aimed to assess the prevalence of IHI in patients with MDD, the link of IHI with hippocampal volume (HV) and the impact of IHI on the predictive value of HV for response and remission after antidepressant treatment., Methods: IHI (right and left, partial and total and IHI scores) and HV were assessed in 60 patients with a current Major Depressive Episode (MDE) in a context of MDD and 60 matched controls. Patients were prospectively assessed at baseline and after one, three and six months of antidepressant treatment for response and remission., Results: The prevalence of IHI did not significantly differ between MDD patients (right = 23.3%; left = 38.3%) and controls (right = 16.7%; left = 33.3%). IHI was not significantly associated with MDD clinical characteristics. IHI alone did not predict response and remission after antidepressant treatment. However, an interaction between left HV and left IHI predicted six-month response (p = 0.04), HDRS score decrease (p = 0.02) and both three-month (p = 0.04) and six-month (p = 0.03) remission. A case-control design in 30 matched patients with or without left IHI confirmed that interaction. In patients without left IHI, left HV at baseline were smaller in six-month non-remitters as compared to remitters (2.2(± 0.43) cm
3 vs 2.97(± 0.5) cm3 p = 0.02), and in six-month non-responders as compared to responders (2.18(± 0.42) cm3 vs 2.86(± 0.54) cm3 , p = 0.03). In patients with left IHI, no association was found between left HV at baseline and antidepressant response and remission., Conclusion: IHI is not more frequent in MDD patients than in controls, is not associated with HV, but is a confounder that decreases the predictive value of hippocampal volume to predict response or remission after antidepressant treatment. IHI should be systematically assessed in future research studies assessing hippocampal volume in MDD.- Published
- 2016
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38. Incomplete Hippocampal Inversion: A Comprehensive MRI Study of Over 2000 Subjects.
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Cury C, Toro R, Cohen F, Fischer C, Mhaya A, Samper-González J, Hasboun D, Mangin JF, Banaschewski T, Bokde AL, Bromberg U, Buechel C, Cattrell A, Conrod P, Flor H, Gallinat J, Garavan H, Gowland P, Heinz A, Ittermann B, Lemaitre H, Martinot JL, Nees F, Paillère Martinot ML, Orfanos DP, Paus T, Poustka L, Smolka MN, Walter H, Whelan R, Frouin V, Schumann G, Glaunès JA, and Colliot O
- Abstract
The incomplete-hippocampal-inversion (IHI), also known as malrotation, is an atypical anatomical pattern of the hippocampus, which has been reported in healthy subjects in different studies. However, extensive characterization of IHI in a large sample has not yet been performed. Furthermore, it is unclear whether IHI are restricted to the medial-temporal lobe or are associated with more extensive anatomical changes. Here, we studied the characteristics of IHI in a community-based sample of 2008 subjects of the IMAGEN database and their association with extra-hippocampal anatomical variations. The presence of IHI was assessed on T1-weighted anatomical magnetic resonance imaging (MRI) using visual criteria. We assessed the association of IHI with other anatomical changes throughout the brain using automatic morphometry of cortical sulci. We found that IHI were much more frequent in the left hippocampus (left: 17%, right: 6%, χ(2)-test, p < 10(-28)). Compared to subjects without IHI, subjects with IHI displayed morphological changes in several sulci located mainly in the limbic lobe. Our results demonstrate that IHI are a common left-sided phenomenon in normal subjects and that they are associated with morphological changes outside the medial temporal lobe.
- Published
- 2015
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39. Depressed suicide attempters have smaller hippocampus than depressed patients without suicide attempts.
- Author
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Colle R, Chupin M, Cury C, Vandendrie C, Gressier F, Hardy P, Falissard B, Colliot O, Ducreux D, and Corruble E
- Subjects
- Adolescent, Adult, Aged, Case-Control Studies, Depressive Disorder, Major psychology, Female, Humans, Male, Middle Aged, Risk Factors, Young Adult, Depressive Disorder, Major complications, Depressive Disorder, Major pathology, Hippocampus pathology, Magnetic Resonance Imaging, Suicide, Attempted psychology
- Abstract
Background: Despite known relationship between hippocampal volumes and major depressive episodes (MDE) and the increased suicidality in MDE, the links between hippocampal volumes and suicidality remain unclear in major depressive disorders (MDD). If the hippocampus could be a biomarker of suicide attempts in depression, it could be useful for prevention matters. This study assessed the association between hippocampal volumes and suicide attempts in MDD., Methods: Hippocampal volumes assessed with automatic segmentation were compared in 63 patients with MDD, with (n = 24) or without (n = 39) suicide attempts. Acute (
one month) suicide attempts were studied., Results: Although not different in terms of socio-demographic, MDD and MDE clinical features, suicide attempters had lower total hippocampus volumes than non-attempters (4.61 (± 1.15) cm(3) vs 5.22 (± 0.99) cm(3); w = 625.5; p = 0.03), especially for acute suicide attempts (4.19 (± 0.81) cm(3) vs 5.22 (± 0.99) cm(3); w = 334; p = 0.005), even after adjustment on brain volumes, sex, age, Hamilton Depression Rating Scale (HDRS) scores and MDD duration. A ROC analysis showed that a total hippocampal volume threshold of 5.00 cm(3) had a 98.2% negative predictive value for acute suicide attempts., Conclusion: Depressed suicide attempters have smaller hippocampus than depressed patients without suicide attempts, independently from socio-demographics and MDD characteristics. This difference is related to acute suicide attempts but neither to past suicide attempts nor to duration since the first suicide attempt, suggesting that hippocampal volume could be a suicidal state marker in MDE. Further studies are required to better understand this association., (Copyright © 2014 Elsevier Ltd. All rights reserved.) - Published
- 2015
- Full Text
- View/download PDF
40. Evaluation of bone marrow mesenchymal stem cell standard cryopreservation procedure efficiency.
- Author
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Carvalho KA, Cury CC, Oliveira L, Cattaned RI, Malvezzi M, Francisco JC, Pachalok A, Olandoski M, Faria-Neto JR, and Guarita-Souza LC
- Subjects
- Animals, Cell Adhesion, Cell Culture Techniques, Cell Differentiation physiology, Cell Separation methods, Cell Survival, Male, Rats, Rats, Wistar, Bone Marrow Cells cytology, Cryopreservation methods, Mesenchymal Stem Cells cytology
- Abstract
Introduction: Mesenchymal stem cells are obtained from a variety of sources, particularly bone marrow. These cells have great potential for clinical research due to their potential to regenerate tissue. As is well known, the cryopreservation process can store any cell type, particularly blood cells, for an indeterminate time., Objective: The aim of this study was to analyze the efficiency of standard cryopreservation procedures for adult mesenchymal stem cells from bone marrow., Methods: Mononuclear stem cells isolated from 10 Wistar male rats were cultivated for 4 weeks to obtain mesenchymal stem cells. The parameters considered in this study were trypan blue exclusion test and annexin V conjugated with 7-amino-actinomycin for flow cytometry before cryopreservation in liquid nitrogen vapor phase for 1 month and after thawing., Results: The viabilities determined by the trypan blue exclusion test were 94.76% and 90.58%, and the flow cytometry assay (annexin V conjugated with 7-amino-actinomycin) were 85.52% and 66.25%, before cryopreservation and after thawing, respectively., Conclusions: Standard procedures for cryopreservation were not efficient for those cells. The flow cytometry assay was more sensitive than the trypan blue exclusion test to demonstrate nonviability.
- Published
- 2008
- Full Text
- View/download PDF
41. Altruistic behavior and the bidimensional just world belief.
- Author
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Bègue L, Charmoillaux M, Cochet J, Cury C, and De Suremain F
- Subjects
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Charities, Child, Female, Humans, Male, Middle Aged, Poverty psychology, Probability, Sex Factors, Surveys and Questionnaires, Altruism, Culture, Social Justice
- Abstract
Thirty participants were sampled after donating charity to a street beggar and were compared by means of 2 short scales of belief in ajust world for self (BJWS) and belief in a just world for others (BJWO) with 30 randomly selected people who passed the beggar by without donating charity. We assumed that BJWO would be negatively related to altruistic behavior, whereas BJWS would be positively linked with it. A logistic regression analysis introducing BJWS, BJWO, and participants' age and gender as predictors showed that BJWO was negatively related to altruistic behavior, whereas the BJWS tended to be positively associated to it. No effects were observed for age or gender.
- Published
- 2008
42. Anterior chamber width measurement.
- Author
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Meyer CH, Mennel S, Cury C, and Sekundo W
- Subjects
- Biometry, Body Weights and Measures, Humans, Anterior Chamber anatomy & histology, Diagnostic Techniques, Ophthalmological, Tomography, Optical Coherence methods
- Published
- 2005
- Full Text
- View/download PDF
43. Aneural culture of rat myoblasts for myocardial transplant.
- Author
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Carvalho KA, Guarita-Souza LC, Rebelatto CL, Senegaglia AC, Hansen P, Mendonca JG, Cury CC, Francisco JC, and Brofman PR
- Subjects
- Animals, Cell Culture Techniques methods, Culture Media, Growth Substances pharmacology, Models, Animal, Myoblasts drug effects, Rats, Heart Transplantation, Myoblasts cytology, Myoblasts transplantation
- Abstract
Due to the peculiar characteristics of skeletal muscle, myoblast transplants have emerged as a therapy for cardiomyopathy, particularly after myocardial infarction. The objectives of this study were to define the mean time of cultivation necessary to obtain a cellular concentration of 10(6) to expand the mass for transplant, and to identify the proliferation phase of myoblasts. Ten myoblast cultures were performed using newborn Wistar rats. The isolation method used enzymatic dissociation in culture medium (HAM-F12 and 199) supplement with basic-fibroblast growth factor (b-FGF) and insulin growth factor (IGF-I). The mean cultivation time to obtain the desired concentration of 10(6) was 7 days, with expansion of up to 10(8)/g. When b-FGF was used, the cellular yield was approximately 10(7), with IGF-I the cellular yield was approximately 10(8), independent of the medium. We concluded that IGF-I is the better option for mass cellular expansion of myoblasts for application in myocardial transplants.
- Published
- 2004
- Full Text
- View/download PDF
44. Could the coculture of skeletal myoblasts and mesenchymal stem cells be a solution for postinfarction myocardial scar?
- Author
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Carvalho KA, Guarita-Souza LC, Rebelatto CL, Senegaglia AC, Hansen P, Mendonça JG, Cury CC, Francisco JC, and Brofman PR
- Subjects
- Animals, Coculture Techniques, Disease Models, Animal, Heart Transplantation, Postoperative Complications therapy, Rats, Mesoderm cytology, Muscle, Skeletal cytology, Myoblasts cytology, Stem Cell Transplantation, Stem Cells cytology
- Abstract
Currently two lines of research have been proposed for treatment of heart failure in an attempt to address its main cause: skeletal myoblast (SM) transplants, which increase the contractile muscular mass, and mesenchymal stem cell (MSC) transplants, which increase neoangiogenesis. The objective of this study was to establish methods whereby cocultures of SM and MSC proliferate and expand, making possible the interaction of these cell types prior to their transplantation to the myocardium. Seeking to support the survival of these cells after myocardial transplantation and achieve subsequent functional improvement, SM and MSC from 10 rats were isolated and cultivated in DMEM medium supplemented with 15% fetal calf serum, 1% ATB, and growth factors. Following plating in variable proportions of satellite cells/mononuclear cells namely 2:1, 1:1, 1:2, morphological observations were made regarding cell survival, adhesion to substrate, and confluence. After 48 hours nonadherent cells were aspirated from the flasks, leaving the adherent cells, SM, and MSC. The better level of cell proliferation was observed with the proportion 2:1 cocultivated at a concentration of 5 x 10(5)/mL for 14 days. The results were satisfactory; the cell production was up to 10(8), increasing the chances of transplant success after myocardial infarction. Transplants with this model are ongoing.
- Published
- 2004
- Full Text
- View/download PDF
45. Pregnancy with a history of treated polyarteritis nodosa.
- Author
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Fernandes SR, Cury CP, and Samara AM
- Subjects
- Adult, Female, Humans, Pregnancy, Polyarteritis Nodosa drug therapy, Pregnancy Complications, Pregnancy Outcome
- Published
- 1996
46. Acquired immunodeficiency syndrome in forensic autopsies.
- Author
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Prints CD, de Mello JA, Guidugli RB, and Cury CG
- Subjects
- Adolescent, Adult, Aged, Autopsy, Cause of Death, Female, Forensic Medicine, Humans, Infant, Male, Middle Aged, Social Problems, Acquired Immunodeficiency Syndrome mortality
- Abstract
From May 1985 to May 1989, 126 necropsies were performed at the São Paulo City Morgue on cadavers of individuals AIDS victims whose unnatural deaths had prompted police investigations. One hundred and nineteen males and 17 females were included. Ages were most commonly in the 20-to-30 year range. Fifty four deaths occurred in penal institutions, 29 deaths resulted from suicides, 17 deaths from manslaughter, 17 deaths were considered suspicious, 5 willful murders and 4 others also considered suspicious because corpses were found in advanced stages of putrefaction. Inmates, except one man who was strangled, died as a consequence of the disease. During all autopsies, special attention was paid to the high rate of extrapulmonary Mycobacterial infections. Suicides were committed in different ways and the majority of the victims were documented to be still in the initial stages of the disease. Suspicious deaths and deteriorated corpses were the result of negligence of the subject's families. Homicidal deaths occurred in subjects in the terminal stages of the disease inside the hospital where these subjects were assisted and the immunodeficiency certainly contributed to aggravate the injuries leading to death. Attention is drawn to both legal and social issues affecting AIDS victims. The authors believe these issues may pose a hindrance for efficient control of the AIDS epidemic.
- Published
- 1994
- Full Text
- View/download PDF
47. [Adrenoleukodystrophy (melanodermic leukodystrophy). Report of an anatomo-clinical case].
- Author
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Brotto MW, Scaff M, Nobrega JP, Cury CG, Salum J, and Canelas HM
- Subjects
- Addison Disease diagnosis, Addison Disease etiology, Addison Disease genetics, Adolescent, Adrenal Glands pathology, Brain pathology, Diffuse Cerebral Sclerosis of Schilder diagnosis, Diffuse Cerebral Sclerosis of Schilder genetics, Humans, Male, Myelin Sheath pathology, Nerve Degeneration, Psychomotor Disorders etiology, Sex Factors, Addison Disease complications, Diffuse Cerebral Sclerosis of Schilder complications
- Abstract
The case of a 14-year-old boy with "diffuse cerebral sclerosis", preceded by signs of primary adrenal cortical insufficiency for 7 years with familiar antecedents is reported. This disorder, named adrenoleukodystrophy, has a sex-lin(ed recessive inheritance. The clinical picture is characterized by mental deterioration, gait disturbances, visual impairment, associated with primary adrenal cortical insufficiency. Confirming the data from literature, in our case the pathological study showed myelin degeneration and diffuse gliosis in the cerebral white matter, with no involvement of subcortical fibers. Inflammatory cells are common, and have a perivascular distribution. In the fasciculata and reticular zones of the adrenal gland, "baloon-shaped" cells are evident, most of them presenting a vacuolized and striated cytoplasm. Similar lipidic inclusions have been found in the Schwann cells of the periheral nerves and testis. The findings are compared with twenty cases from the literature.
- Published
- 1979
- Full Text
- View/download PDF
48. [Experimental arteriosclerosis in Wistar rats given a low-protein diet].
- Author
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Giannini SD, Sanchis FS, and Cury CG
- Subjects
- Animals, Arteriosclerosis etiology, Arteriosclerosis pathology, Cholesterol, Dietary adverse effects, Dehydrocholic Acid adverse effects, Ergocalciferols adverse effects, Lipids blood, Male, Rats, Arteries pathology, Arteriosclerosis chemically induced, Diet, Atherogenic
- Published
- 1980
49. [Clinical, anatomopathological and virological study of a case of fetal vaccinia].
- Author
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dos Santos AU, Cury CG, Pimenta de Campos E, Sakuma ME, Curti SP, and de Barros AC
- Subjects
- Adolescent, Female, Humans, Pregnancy, Skin pathology, Vaccinia virus isolation & purification, Fetal Diseases pathology, Vaccinia pathology
- Published
- 1985
50. [Incidence of obstructive lesions in the coronary artery system among the active population of the city of São Paulo].
- Author
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Dias AR, Mazzone A, de Freitas D, Janovich HG, Gefter M, Morais CF, Cury CG, Lopes EA, and Jatene AD
- Subjects
- Accidents, Adolescent, Adult, Aged, Brazil, Coronary Disease pathology, Female, Humans, Male, Middle Aged, Coronary Disease epidemiology
- Published
- 1986
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