Search

Your search keyword '"Curwen J"' showing total 126 results
Start Over Author "Curwen J"
126 results on '"Curwen J"'

4. PAPERS IN AGRICULTURE

Author

AINSLIE, H., Dixon, William, AUSTIN, JOHN, Hamilton, Stewart, Hamilton, Arthur, Hamilton, J., Hamilton, James, FOWLER, R., RICHARDSON, W., VALLANCEY, C., COOTE, CHARLES, HAGGITT, FRANCIS, WOODIFIELD, M., LYNN, W., HESLEDEN, BRYAN, Hodgson, John Matthew, MOGGRIDGE, JOHN H., GALTON, SAMUEL, CURWEN, J. C., FRANKLYN, ISAAC, SKURRAY, CHARLES THOMAS, Tyeth, W., Wood, Leo., Dene, John, FINCH, JOHN, HODGE, ARTHUR, ASTLEY, FRANCIS DUKINFIELD, PETIT, LOUIS HAYES, SAMPSON, WILLIAM, and BRAITHWAITE, MILES

Published
1812

5. PAPERS IN AGRICULTURE

Author

CURWEN, J. C., DYKES, J. D. B., Gaff, Thomas, Foster, Matthew, Waistell, Charles, PHILLIPS, RICHARD, Bourke, J. W., Kiernan, P. M, Donne, Jas., Morrall, C., Morrall, W., Croxon, Richard, CHEETHAM, WILLIAM, Olerenshaw, M., Wood, Ralph, Bridge, Ralph, Bridge, David, Bowden, Thomas, Olerenshaw, Thomas, Wild, Emanuel, Ferris, George, CALTHROP, J. G., WADE, J. S., Layton, Charles, DEAN, JAMES, Baker, John, Cockerill, Dan., Long, Rt., and SALMON, ROBERT

Published
1806

6. PAPERS IN AGRICULTURE

Author

Curwen, J. C., Borron, J. A., Taylor, Charles, Plowman, Thomas, Hutton, John, Idle, Benjamin, Ridley, Francis, Jackson, Thomas, Pearce, Wm., Kempthorne, James, Humphries, Thomas, Waistell, Charles, Simpson, Edward, Parker, Thomas N., Watson, W., Shirreff, John, Shirreff, T., and De Lancey, J.

Published
1804

7. PAPERS IN AGRICULTURE

Author

Mac Vean, C., Robertson, Robert, Cameron, Hugh, Todd, James, Johnes, Thomas, Richards, David, Curwen, I.C., CURWEN, J. C., Eden, John, Miller, John, Taylor, Samuel, Mason, W. Wallis, Farey, John, Smith, William, Watson, W., Bull, Seth, Mules, Charles, and Lutt,, Edward

Published
1805

8. PAPERS IN AGRICULTURE

Author

Geddes, John, Cheshalsne, Alex., Chisholm, John, Trig, John, Young, Wm., Turner, Thomas, Bristowe, John, Pickin, W., Shirreff, John, Munnings, Thomas Crowe, Christmas, James, Tuck, John, Royal, John, Gant, John, Knapping, John, Wise, J., Ellwood, T., Potton, Wm., Wiggins, T., Witton, Edm., Bannester, F., Meakens, W., Wright, John, Curwen, J. C., Pierrepont, W., Cartwright, Edmund, Baxter, William, Green, Robert, Ainslie, H., Waddington, Benjamin, Powell, Willm., Prees, Philip, Prees, Willm., Sharp, John, Bucknall, Tho. Skip Dyot, and Hardy, Joseph

Published
1803

9. PAPERS IN AGRICULTURE

Author

Hunter, John, Staintforth, G., Taylor, Charles, Curwen, J., Vernon, Henry, Gray, Lawrence, Cherry, Frederick Clifford, Cherry, F. C., Allen, Wm., Harwood, Rich., Bull, Seth, Arnold, Charles, Gibson, Charles, Landaff, R., Brown, Robert, Dickinson, William, Bucknall, Thomas Skip Dyot, Fairman, Wm., Johnes, T., Todd, James, Beech, James, and Cochrane, Spencer

Published
1802

10. PAPERS IN AGRICULTURE

Author

Curwen, J. C., MORE, Hodgson, Thomas, Sutton, John, Crisp, John, Berrett, Robert, Denny, John, Smith, Joseph, Kilderbee, Samuel, Storer, John, Majendie, Lewis, Montgomerie, James, Caswall, George, Myall, Barker, Bird, Thomas, Toon, Thomas, Pindard, Isaac, Todd, W., Fife, Geddes, John, Duncan, James, Bucknall, Thomas Skip Dyot, Thomas, W., Martin, Henry, Mundell, Robert, Filewood, James, Stillingfleet, James, Hey, Wm., Dikes, Thomas, Wood, John, Jones, Thomas, Shaw, William, Billingsley, J., Tudway, Clement, Lovell, John, Oakeley, William, Owen, Ev., Gryffydh, John, Todd, James, Hoskins, Jos., Irwin, James, Sewell, Wm., Upton, Charles, Cox, Wm., Cox, Edward L., Witherall, J. L., Goodwin, George, Cox, William, Scott, Adam, Weston, John Webbe, Boehm, Edmund, Billingsley, John, and Braithewaite, Reg.

Published
1797

14. Come along, Sam

Author

Curwen, J. Spencer, Mrs., 1845-1932, composer.

Published
1913

26. Tricyclic indazoles a novel class of selective estrogen receptor degrader antagonists

Author

Scott, J.S., primary, Bailey, A., additional, Buttar, D., additional, Carbajo, R.J., additional, Curwen, J., additional, Davies, R.D.M., additional, Degorce, S.L., additional, Donald, C., additional, Gangl, E., additional, Greenwood, R., additional, Groombridge, S.D., additional, Johnson, T., additional, Lamont, S., additional, Lawson, M., additional, Lister, A., additional, Morrow, C., additional, Moss, T., additional, Pink, J.H., additional, and Polanski, R., additional

Published
2019
Full Text
View/download PDF

28. PAPERS IN AGRICULTURE

Author

POUND, MATTHEW, Thoroton, John, Wood, William, Dolby, William, Welby, W. E., CURWEN, J. C., ELLIOT, G. SCOTT, ELLIS, L., GLOVER, WM., Aitkin, George, Hoorlos, Wm., Congreve, William, Knipe, J., Stephens, Wm., Hickman, Wm., MEEK, MICHAEL, Nicholson, John, Anderson, John, Markham, George, Powell, William, THORNHILL, BACHE, Gell, P., Beittlebank, Wm., Coke, D'Ewes, Brittlebank, Wm., Gell, Philip, Hall, J. G., Painter, Henry, HALL, JAMES G., HALL, JAMES, and Painter, Stephen

Published
1816

29. PAPERS IN AGRICULTURE

Author

LIDDELL, WILLIAM, Hayes, Thomes, Green, James, Yeoman, William, Kirby, Francis, HIGGINS, GODFREY, Wilson, Matthew, Lindley, Thomas, Wildman, John, BACKHOUSE, EDWARD, Thompson, James, Charlton, Edw., SCOTT, T. H., Poore, John, Ross, John, FOULKES, JOHN, WILKINSON, JAMES, Fielding, James, BRABY, JAMES, PHILLIPPS, LEONARD, Guthrie, J., CURWEN, J. C., Glover, William, Thompson, Thomas, CHAMBERLAINE, JOHN, CLAGUE, ANN, and Thackeray, W. W.

Published
1814

30. PAPERS IN AGRICULTURE

Author

CURWEN, J. C., Litt, John, Thompson, Ben., Hoodless, Wm,, THORNHILL, BACKE, Nuttall, John, Brittlecomb, Wm., Gell, P., Pontey, Wm., COAPE, HENRY, Rush, William, Dines, Jacob, Glascock, John, Baker, James, OGDEN, JAMES, NICHOLLS, H. J., WAY, H. B., and BOWLER, WILLIAM

Published
1815

32. PAPERS IN AGRICULTURE

Author

LEE, H. P., NICHOLLS, SAMUEL, JOHNES, THOMAS, CURWEN, J. C., PETRE, J. BERNEY, Lloyd, Thomas, Cooper, T. H., TOWERS, RICHARD, BALLS, THOMAS, ASTLEY, J. H., BAKER, JOHN, JEFFERY, WILLIAM, and HUTTON, JOSEPH

Published
1810

33. PAPERS IN MECHANICS

Author

BOLTON, Wm., BALL, H. L., ROBERTS, THOMAS, THOMPSON, THOS. B., RULE, W., LEGGE, HENRY, FAWKENER, W., BICKERTON, R., HOPE, W. JOHNSTONE, WARD, R., LE HARDY, CHARLES, EDELCRANTZ, A. N., RICHARDSON, ROBERT, CURWEN, J. C., WRIGHT, ROBERT, GILPIN, GILBERT, TAD, JOHN, BRUNEL, M. J., BARLOW, Wm., CLEGG, ASHWORTH, CLEGG, S., WARD, H., WARD, HENRY, MANBY, GEO. W., MANBY, GEO. Wm., MAURICE, M., PROUTING, JOHN, HUNTINGTON, I. B., SALMON, B. W., WHEATLEY, FRANCIS, and FOWLER, JOHN

Published
1808

34. PAPERS IN AGRICULTURE

Author

BEATTIE, WILLIAM, LANDAFF, R., Atkinson, Robert, BORINGD0N, Chaffon, Richard, Yolland, John, Pearce, William, LAWRENCE, WILLIAM, Waring, J., Francis, R., Clark, Rt., Shynm, James, Francis, D. P., LAWRENCE, WM., BAIN, A., WAISTELL, CHARLES, CURWEN, J. C., Knott, Willliam, Sunderand, Marshall, J. Penny, Tart, Thomas, Armstead, William, Staller, William, Eidsforth, Anthony, Atkinson, Christopher, Edmondson, Robert, YOUNG, ARTHUR, BURROWS, ROBERT, Le Neve Fostee, Peter, Elmer, John, May, William Fitz, Bond, John, Norton, James, BUTLER, J., Mence, Samuel, Curtis, George, Denyer, Francis, Chase, James, Money, William, Fullech, John, Rowland, John, CURTIS, SAMUEL, PARKINSON, R., MASON, W. WALLIS, Naish, John Foord, Bryan, Thomas, Oram, William, Ledrooke, William, Cattell, Richard, and FISHER, TIMOTHY

Published
1808

35. PAPERS IN AGRICULTURE

Author

CURWEN, J. C., THACKERAY, W. M., CONGREVE, WILLIAM, LESTER, W., FARQUHARSON, JAMES JOHN, CLARKE, JOHN, SALISBURY, WILLIAM, Reith, Alexander, Woodhood, John, SALISBURY, Wm., THOMPSON, A. T., LE HARDY, CHARLES, Le Couteur, Fr., Durell, P., Mallet, J., Le Maistre, Charles, Bisson, A., HALL, JAMES, Adams, William, Bullock, Edward, Gardner, Wm., Houne, John, Alford, Thomas, HUME, JOS., DAVY, H., SADDINGTON, JOHN, COCHRANE, SPENCER, and WAISTELL, CHARLES

Published
1809

36. IGFR-1R complex with a pyrimidine inhibitor.

Author

Degorce, S., primary, Boyd, S., additional, Curwen, J., additional, Ducray, R., additional, Halsall, C., additional, Jones, C., additional, Lach, F., additional, Lenz, E., additional, Pass, M., additional, Pass, S., additional, Trigwell, C., additional, Norman, R., additional, and Phillips, C., additional

Published
2016
Full Text
View/download PDF

37. 546 The PI3Kbeta/delta inhibitor AZD8186 combines with the dual mTORC1/2 inhibitor AZD2014 to give comprehensive PI3K pathway inhibition and drive tumour regression in vivo

Author

Simon, B., primary, Hancox, U., additional, Polanska, U., additional, Hanson, L., additional, Dudley, P., additional, Ellston, R., additional, Maynard, J., additional, Kraus, M., additional, Curwen, J., additional, Klinowska, T., additional, Ward, L., additional, Cruzalegui, F., additional, Symeonides, S., additional, and Cronin, K., additional

Published
2014
Full Text
View/download PDF

38. Abstract P5-09-20: Development of a novel selective estrogen receptor down-regulator which shows efficacy in pre-clinical models of endocrine resistance

Author

Weir, H, primary, Nardone, A, additional, Lawson, M, additional, Rowlinson, R, additional, Hulse, M, additional, Powell, S, additional, Callis, R, additional, Walker, G, additional, Curwen, J, additional, Wilson, Z, additional, Bradbury, R, additional, Rabow, Al, additional, de Savi, C, additional, Pazolli, E, additional, Reavey, N, additional, D'Cruz, C, additional, and Schiff, R, additional

Published
2013
Full Text
View/download PDF

45. Discovery of a New Class of Anilinoquinazoline Inhibitors with High Affinity and Specificity for the Tyrosine Kinase Domain of c-Src

Author

Ple, P. A., Green, T. P., Hennequin, L. F., Curwen, J., Fennell, M., Allen, J., Brempt, Lambert-van der, C., and Costello, G.

Abstract

Deregulated activity of the nonreceptor tyrosine kinase c-Src is believed to result in signal transduction, cytoskeletal and adhesion changes, ultimately promoting a tumor-invasive phenotype. We report here the discovery of a new class of anilinoquinazoline inhibitors with high affinity and specificity for the tyrosine kinase domain of the c-Src enzyme. Special attention was directed toward finding inhibitors selective against KDR tyrosine kinase in order to ensure that the in vivo profile of a specific Src inhibitor could be determined. The 4-aminobenzodioxole quinazoline series gave compounds with excellent potency and selectivity. The most interesting compounds were evaluated in vivo and displayed good pharmacokinetics following oral dosing. Compounds such as the aminobenzodioxoles were shown to be potent inhibitors of tumor growth in a c-Src-transformed 3T3 xenograft model in vivo, resulting in more than 90% growth inhibition at doses as low as 6 mg/kg po once daily. Src tyrosine kinase inhibitors such as these may provide a novel therapeutic modality for targeting cancer invasion and metastasis.

Published
2004

46. Novel 4-Anilinoquinazolines with C-7 Basic Side Chains:  Design and Structure Activity Relationship of a Series of Potent, Orally Active, VEGF Receptor Tyrosine Kinase Inhibitors

Author

Hennequin, L. F., Stokes, E. S. E., Thomas, A. P., Johnstone, C., Ple, P. A., Ogilvie, D. J., Dukes, M., Wedge, S. R., Kendrew, J., and Curwen, J. O.

Abstract

We have previously shown that 4-anilinoquinazolines can be potent inhibitors of vascular endothelial growth factor (VEGF) receptor (Flt-1 and KDR) tyrosine kinase activity. A novel subseries of 4-anilinoquinazolines that possess basic side chains at the C-7 position of the quinazoline nucleus have been synthesized. This subseries contains potent, nanomolar inhibitors of KDR (median IC50 0.02 μM, range 0.001−0.04 μM), which are comparatively less potent vs Flt-1 tyrosine kinase (median IC50 0.55 μM, range 0.02−1.6 μM). The compounds also retain some inhibitory activity against the tyrosine kinase associated to the endothelial growth factor receptor (EGFR) (median IC50 0.2 μM, range 0.075−0.8 μM) but demonstrate selectivity vs that associated to the FGF receptor 1 (median IC50 2.5 μM, range 0.9−19 μM). This selectivity profile is also evident in a growth factor-stimulated human endothelial cell (HUVEC) proliferation assay (i.e., inhibition of VEGF > EGF > FGF), with inhibition of VEGF-induced proliferation being achieved at nanomolar concentrations (median IC50 0.06 μM). Further examination of compound 2 (ZD6474) in recombinant enzyme assays revealed excellent selectivity for the inhibition of KDR tyrosine kinase (IC50 0.04 μM) vs the kinase activity of erbB2, MEK, CDK-2, Tie-2, IGFR-1R, PDK, PDGFRβ, and AKT (IC50 range: 1.1 to >100 μM). Anilinoquinazolines possessing basic C-7 side chains exhibited markedly improved aqueous solubility over previously described anilinoquinazolines possessing neutral C-7 side chains (up to 500-fold improvement at pH 7.4). In addition, aqueous solubility of the neutral fraction present at pH 7.4 of the basic subseries of anilinoquinazoline proved to be higher than that of the neutral analogue 1 (ZD4190). Oral administration of representative compounds to mice (50 mg/kg) produced plasma levels between 0.2 and 3 μM at 24 h after dosing. Our development candidate 2 demonstrated a very attractive in vitro profile combined with excellent solubility (330 μM at pH 7.4) and good oral bioavailability in rat and dog (>80 and >50%, respectively). This compound demonstrated highly significant, dose-dependent, antitumor activity in athymic mice. Once daily oral administration of 100 mg/kg of compound 2 for 21 days inhibited the growth of established Calu-6 lung carcinoma xenografts by 79% (P < 0.001, Mann Whitney rank sum test), and substantial inhibition (36%, P < 0.02) was evident with 12.5 mg/kg/day.

Published
2002
Full Text
View/download PDF

47. Design and Structure−Activity Relationship of a New Class of Potent VEGF Receptor Tyrosine Kinase Inhibitors

Author

Hennequin, L. F., Thomas, A. P., Johnstone, C., Stokes, E. S. E., Ple, P. A., Lohmann, J.-J. M., Ogilvie, D. J., Dukes, M., Wedge, S. R., Curwen, J. O., Kendrew, J., Brempt, Lambert-van der, and C.

Abstract

A series of substituted 4-anilinoquinazolines and related compounds were synthesized as potential inhibitors of vascular endothelial growth factor (VEGF) receptor (Flt and KDR) tyrosine kinase activity. Enzyme screening indicated that a narrow structure−activity relationship (SAR) existed for the bicyclic ring system, with quinazolines, quinolines, and cinnolines having activity and with quinazolines and quinolines generally being preferred. Substitution of the aniline was investigated and clearly indicated that small lipophilic substituents such as halogens or methyl were preferred at the C-4‘ position. Small substituents such as hydrogen and fluorine are preferred at the C-2‘ position. Introduction of a hydroxyl group at the meta position of the aniline produced the most potent inhibitors of Flt and KDR tyrosine kinases activity with IC50 values in the nanomolar range (e.g. 10, 12, 13, 16, and 18). Investigation of the quinazoline C-6 and C-7 positions indicates that a large range of substituents are tolerated at C-7, whereas variation at the C-6 is more restricted. At C-7, neutral, basic, and heteroaromatic side chains led to very potent compounds, as illustrated by the methoxyethoxy derivative 13 (IC50 < 2 nM). Our inhibitors proved to be very selective inhibitors of Flt and KDR tyrosine kinase activity when compared to that associated with the FGF receptor (50- to 3800-fold). Observed enzyme profiles translated well with respect to potency and selectivity for inhibition of growth factor stimulated proliferation of human umbilical vein endothelial cells (HUVECs). Oral administration of selected compounds to mice produced total plasma levels 6 h after dosing of between 3 and 49 μM. In vivo efficacy was demonstrated in a rat uterine oedema assay where significant activity was achieved at 60 mg/kg with the meta hydroxy anilinoquinazoline 10. Inhibition of growth of human tumors in athymic mice has also been demonstrated: compound 34 inhibited the growth of established Calu-6 lung carcinoma xenograft by 75% (P < 0.001, one tailed t-test) following daily oral administration of 100 mg/kg for 21 days.

Published
1999

Catalog

Books, media, physical & digital resources
See catalog results