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176 results on '"Curtoni, E. S."'

10. Analysis of HLA-DR Typing Sera Used in the Workshop Transplant Study

Author

Amoroso, A., Curtoni, E. S., Opelz, G., Piazza, A., Rendine, S., Albert, Ekkehard D., editor, Baur, Max P., editor, Mayr, Wolfgang R., editor, Bertrams, J., editor, Goldmann, S., editor, Grosse-Wilde, H., editor, Opelz, G., editor, Rittner, C., editor, Schendel, D. J., editor, Scholz, S., editor, and Wank, R., editor

Published
1984
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11. Serologic characterization of human Ia antigens using B cell lymphoid lines

Author

Bodmer, J., Young, D., Jones, E., Colin Barnstable, Goodfellow, P., Bodmer, W., Svejgaard, A., Thomsen, M., Trucco, M., Curtoni, E. S., Festenstein, H., and Sachs, J.

Abstract

This article discusses the detection of Ia antibodies in HLA-typing sera using B-cell lymphoid lines, the grouping of the sera into five preliminary clusters, and their associations with D-locus specificities.

Published
2016

12. Antigen Report: HLA-DR4

Author

Williamson, J., primary, Tait, B., additional, Richiardi, P., additional, Awad, J., additional, Fauchet, R., additional, Curtoni, E. S., additional, Festenstein, H., additional, and Dawkins, R. L., additional

Published
1984
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13. Antigen Report: HLA-A2

Author

Curtoni, E. S., primary, Lawler, S. D., additional, Kennedy, L. J., additional, Marshall, W. H., additional, and Wakeling, W., additional

Published
1984
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19. Cytotoxic T lymphocyte precursor frequency as a predictor of acute graft-versus-host disease in bone marrow transplantation from HLA-identical siblings

Author

Affaticati, P, Locatelli, Franco, Roggero, S, Marmont, F, Falda, M, Dall'Omo, A M, Busca, A, Ceretto, C, Praticò, L, Berrino, M, Curtoni, E S, Locatelli, F (ORCID:0000-0002-7976-3654), Affaticati, P, Locatelli, Franco, Roggero, S, Marmont, F, Falda, M, Dall'Omo, A M, Busca, A, Ceretto, C, Praticò, L, Berrino, M, Curtoni, E S, and Locatelli, F (ORCID:0000-0002-7976-3654)

Abstract

The measurement of precursor frequencies of donor anti-recipient cytotoxic T lymphocytes (CTL-p) has been shown to predict the incidence and the severity of acute graft-versus-host disease (aGVHD) in unrelated donor bone marrow transplantation (BR IT). In HLA-identical sibling BMT, where aGVHD is most likely caused by minor histocompatibility antigen mismatches, this assay did not appear to be sensitive enough to provide similar predictive information. In this study, the CTL-p frequencies and the incidence and severity of aGVHD in 51 onco-hematological patients transplanted from HLA-identical siblings were compared. Sibling donors were selected on the basis of HLA identity using serological typing for HLA-A, B, C antigens, whereas HLA-DRB was tested by molecular analysis. Sibling identity was also confirmed by DNA heteroduplex analyses. Fifteen out of 21 (71%) patients with high precursor frequency (>1:100 x 10(3)) and 12 out of 30 (40%) with low precursor frequency (<1:100 x 10(3)) experienced clinically significant (II-IV) aGVHD. A significant correlation (P = 0.04) between CTL-p frequency and severe aGVHD was demonstrated. Moreover there was a positive trend for a high frequency response according to an increasing grade of aGVHD, which was statistically significant (P = 0.04). In our experience the CTL-p assay is a helpful predictive test for aGVHD in HLA-identical sibling BMT, indicating high risk patients possibly requiring additional prophylaxis.q351uf 3

Published
2000

24. Familial occurrence of primary glomerulonephritis: evidence for a role of genetic factors

Author

Scolari, F., primary, Amoroso, A., additional, Savoldi, Silvana, additional, Prati, Elisabetta, additional, Scaini, Patrizia, additional, Manganoni, Annunciata, additional, Borelli, Iolanda, additional, Mazzola, Gina, additional, Canale, Lorena, additional, Sacchi, G., additional, Miglietti, Nunzia, additional, Cristinelli, L., additional, Curtoni, E. S., additional, Binda, P. L., additional, Bonomelli, D., additional, and Maiorca, R., additional

Published
1992
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27. Analysis of the turin umbilical cord blood bank registry.

Author

Rendine S, Curtoni ES, Francia de Celle P, Berrino M, Barbanti M, Saracco P, Fazio L, Gay E, Dall'Omo AM, Rendine, S, Curtoni, E S, di Celle, P F, Berrino, M, Bertola, L, Barbanti, M, Saracco, P, Fazio, L, Gay, E, and Dall'Omo, A M

Published
2000

43. Identification of anti-DQ alloantisera correlated with DR5

Author

Tiziana Crepaldi, Fasano, M. E., Frattasio, C., Centis, D., Curtoni, E. S., and Richiardi, P.

Subjects
B-Lymphocytes, Epitopes, Antibody Specificity, Genetic Linkage, Isoantibodies, HLA-DQ Antigens, Histocompatibility Antigens Class II, Antibodies, Monoclonal, Humans, HLA-DR5 Antigen, Monocytes
Abstract

Using classical serological methods, we have been able to distinguish anti-HLA-DR from anti-DQ antibodies. The specificity of alloantisera for DQ could be identified on the basis of differential reactivity against B cell and monocyte-enriched leucocyte suspensions and lack of inhibition of cytotoxicity by anti-DR monoclonal antibodies. Some alloantisera, whose reactivity was significantly correlated with DR5, were found to exhibit these characteristics. The suggestion that they recognize DQ specificities in linkage disequilibrium with DR5 was supported by immunochemical analysis.

Published
1985

44. HLA antigens and clinical manifestations in Crohn's disease

Author

Modena, V., antonio amoroso, Frattasio, C., Pera, A., Costantini, P., Maiocco, I., Ponti, V., Centanaro Di Vittorio, C., Verme, G., and Curtoni, E. S.

Subjects
Adult, Animals, Arthritis, Rheumatoid, Cats, Colitis, Crohn Disease, Female, HLA Antigens, Humans, Ileitis, Male, Spondylitis, Ankylosing, Ankylosing, Arthritis, Rheumatoid, Spondylitis
Abstract

A clinical, radiological and immunogenetical study was carried out on 51 Crohn's patients. Rheumatological disorders were found in 16 of them, with higher frequency in those with colon involvement only. A statistically significant increase in the frequencies of HLA-A9 and HLA-Cw3 was noted: Cw3 showed a particularly high frequency in males, and A9 in younger patients. The frequency of HLA-B27 was significantly increased in the patients with colon involvement. In the group of 16 patients with rheumatic diseases HLA antigen frequencies were not significantly different from the control population.

Published
1988

46. HLA antigens in juvenile dermatitis herpetiformis

Author

Richiardi, P., Borelli, I., Fabio MALAVASI, Curtoni, E. S., Berti, E., Gianotti, F., and Giannetti, A.

Subjects
Male, Celiac Disease, Adolescent, Gene Frequency, HLA Antigens, Child, Preschool, Dermatitis Herpetiformis, Humans, Female, Dermatology, General Medicine, Child
Abstract

The incidence of histocompatibility antigens HLA-A, B, C, DR was studied in 32 Italian children with dermatitis herpetiformis. A significantly increased relative risk was found for B8 (R.R.=6.2), which was present in 50% of the patients as against 14% of the controls and for DR3 (R.R.=11.7), present in 69% of the patients as against 16%. DR7 also appeared to be increased, but only among DR3-negative patients. There was no significant difference in the incidence of DR3 between children with abnormal and normal jejunal biopsy, though there does seem to be a difference in expressivity of the intestinal involvement between DR3 apparent homozygous, DR3 heterozygous and DR3-negative patients.

Published
1981

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