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252 results on '"Curto, C."'

1. [Translated article] Cost of Treating Cutaneous T-Cell Lymphoma in Spain: Analysis of MICADOS Study Data by Disease Stage

Author

Navarro Matilla, B., Ortiz Romero, P.L., Pujol Vallverdú, R.M., Combalia Escudero, A., Zapata Paz, I., González Barca, E., Muniesa Montserrat, C., Morillo Andújar, M., Pérez Ferriols, A., Román Curto, C., Fernández de Misa Cabrera, R., Hospital Gil, M., Marín Niebla, A., Rios Rull, P.J., de la Cruz Vicente, F., Izu Belloso, R.M., Martín García-Sancho, A., Parera Amer, M.E., Córdoba Mascuñano, R., Ramón Quiles, M.D., Saus Carreres, A., del Campo García, R., Machan, S., Viguera Ester, P., and Blanco Garnelo, J.

Published
2024
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2. Evaluación de los costes asociados a la enfermedad de pacientes con linfoma cutáneo de células T en España: análisis en función del estadio clínico (estudio MICADOS)

Author

Navarro Matilla, B., Ortiz Romero, P.L., Pujol Vallverdú, R.M., Combalia Escudero, A., Zapata Paz, I., González Barca, E., Muniesa Montserrat, C., Morillo Andújar, M., Pérez Ferriols, A., Román Curto, C., Fernández de Misa Cabrera, R., Hospital Gil, M., Marín Niebla, A., Rios Rull, P.J., de la Cruz Vicente, F., Izu Belloso, R.M., Martín García-Sancho, A., Parera Amer, M.E., Córdoba Mascuñano, R., Ramón Quiles, M.D., Saus Carreres, A., del Campo García, R., Machan, S., Viguera Ester, P., and Blanco Garnelo, J.

Published
2024
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4. MicroRNA (miR)‐203 and miR‐205 expression patterns identify subgroups of prognosis in cutaneous squamous cell carcinoma

Author

Cañueto, J, Cardeñoso‐Álvarez, E, García‐Hernández, JL, Galindo‐Villardón, P, Vicente‐Galindo, P, Vicente‐Villardón, JL, Alonso‐López, D, De Las Rivas, J, Valero, J, Moyano‐Sanz, E, Fernández‐López, E, Mao, JH, Castellanos‐Martín, A, Román‐Curto, C, and Pérez‐Losada, J

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Biotechnology, Genetics, Aetiology, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, 2.1 Biological and endogenous factors, Biomarkers, Carcinoma, Squamous Cell, Cell Line, Tumor, Cell Transformation, Neoplastic, Disease Progression, Humans, MicroRNAs, Neoplasm Grading, Prognosis, Skin Neoplasms, Clinical Sciences, Dermatology & Venereal Diseases, Clinical sciences
Abstract

BackgroundCutaneous squamous cell carcinoma (CSCC) is the second most widespread cancer in humans and its incidence is rising. These tumours can evolve as diseases of poor prognosis, and therefore it is important to identify new markers to better predict its clinical evolution.ObjectivesWe aimed to identify the expression pattern of microRNAs (miRNAs or miRs) at different stages of skin cancer progression in a panel of murine skin cancer cell lines. Owing to the increasing importance of miRNAs in the pathogenesis of cancer, we considered the possibility that miRNAs could help to define the prognosis of CSCC and aimed to evaluate the potential use of miR-203 and miR-205 as biomarkers of prognosis in human tumours.MethodsSeventy-nine human primary CSCCs were collected at the University Hospital of Salamanca in Spain. We identified differential miRNA expression patterns at different stages of CSCC progression in a well-established panel of murine skin cancer cell lines, and then selected miR-205 and miR-203 to evaluate their association with the clinical prognosis and evolution of human CSCC.ResultsmiR-205 was expressed in tumours with pathological features recognized as indicators of poor prognosis such as desmoplasia, perineural invasion and infiltrative growth pattern. miR-205 was mainly expressed in undifferentiated areas and in the invasion front, and was associated with both local recurrence and the development of general clinical events of poor evolution. miR-205 expression was an independent variable selected to predict events of poor clinical evolution using the multinomial logistic regression model described in this study. In contrast, miR-203 was mainly expressed in tumours exhibiting the characteristics associated with a good prognosis, was mainly present in well-differentiated zones, and rarely expressed in the invasion front. Therefore, the expression and associations of miR-205 and miR-203 were mostly mutually exclusive. Finally, using a logistic biplot we identified three clusters of patients with differential prognosis based on miR-203 and miR-205 expression, and pathological tumour features.ConclusionsmiR-205 and miR-203 tended to exhibit mutually exclusive expression patterns in human CSCC. This work highlights the utility of miR-205 and miR-203 as prognostic markers in CSCC.

Published
2017

7. Threefold flops via matrix factorization

Author

Curto, C and Morrison, DR

Subjects
math.AG, 14E05 (Primary) 14B07, General Mathematics, Pure Mathematics
Abstract

The explicit McKay correspondence, as formulated by Gonzalez- Sprinberg and Verdier, associates to each exceptional divisor in the minimal resolution of a rational double point, a matrix factorization of the equation of the rational double point. We study deformations of these matrix factorizations, and show that they exist over an appropriate "partially resolved" deformation space for rational double points of types A and D. As a consequence, all simple flops of lengths 1 and 2 can be described in terms of blowups defined from matrix factorizations. We also formulate conjectures which would extend these results to rational double points of type E and simple flops of length greater than 2. © 2013 University Press, Inc.

Published
2013

8. Superspace Geometrical Realization of the N-Extended Super Virasoro Algebra and its Dual

Author

Curto, C., Gates, S. J., and Rodgers, V. G. J.

Subjects
High Energy Physics - Theory
Abstract

We derive properties of N-extended GR super Virasoro algebras. These include adding central extensions, identification of all primary fields and the action of the adjoint representation on its dual. The final result suggest identification with the spectrum of fields in supergravity theories and superstring/M-theory constructed from NSR N-extended supersymmetric ${\cal {GR}}$ Virasoro algebras., Comment: 17 pages Latex Typos in TeX file has been corrected

Published
2000
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9. Evaluación de los costes asociados a la enfermedad de pacientes con linfoma cutáneo de células T en España: análisis en función del estadio clínico (estudio MICADOS)

Author

Navarro Matilla, B., primary, Ortiz Romero, P.L., additional, Pujol Vallverdú, R.M., additional, Combalia Escudero, A., additional, Zapata Paz, I., additional, González Barca, E., additional, Muniesa Montserrat, C., additional, Morillo Andújar, M., additional, Pérez Ferriols, A., additional, Román Curto, C., additional, Fernández de Misa Cabrera, R., additional, Hospital Gil, M., additional, Marín Niebla, A., additional, Rios Rull, P.J., additional, de la Cruz Vicente, F., additional, Izu Belloso, R.M., additional, Martín García-Sancho, A., additional, Parera Amer, M.E., additional, Córdoba Mascuñano, R., additional, Ramón Quiles, M.D., additional, Saus Carreres, A., additional, del Campo García, R., additional, Machan, S., additional, Viguera Ester, P., additional, and Blanco Garnelo, J., additional

Published
2023
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14. Brentuximab vedotin in the treatment of cutaneous T-cell lymphomas: data from the Spanish Primary Cutaneous Lymphoma Registry

Author

Muniesa, C, primary, Gallardo, F, additional, García-Doval, I, additional, Estrach, MT, additional, Combalia, A, additional, Morillo-Andújar, M, additional, De la Cruz Vicente, F, additional, Machan, S, additional, Moya-Martínez, C, additional, Rovira, R, additional, Sanchez-Gonzalez, B, additional, Acebo, E, additional, Amutio, E, additional, Peñate, Y, additional, Losada-Castillo, MC, additional, García-Muret, MP, additional, Iznardo, H, additional, Román-Curto, C, additional, Cañueto, J, additional, de Misa, R Fernández, additional, Flórez, A, additional, Izu, R, additional, Torres-Navarro, I, additional, Zayas, A, additional, Pérez-Paredes, G, additional, Blanes, M, additional, Yanguas, JI, additional, Pérez-Ferriols, A, additional, Callejas-Charavia, M, additional, Ortiz-Romero, PL, additional, Pérez-Gil, A, additional, Prieto-Torres, L, additional, González-Barca, E, additional, and Servitje, O, additional

Published
2022
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15. Outcome of cutaneous squamous cell carcinoma with microscopic residual disease after surgery and usefulness of postoperative radiotherapy: a retrospective cohort study

Author

Revelles‐Peñas, L., primary, Revilla‐Nebreda, D., additional, Becerril, S., additional, Corchete, L.A., additional, Domínguez‐Rullán, I., additional, Martins‐Lopes, M., additional, Arias‐Rodríguez, P., additional, Rodríguez‐Guitiérrez, A., additional, Pérez‐Romansanta, L.A., additional, Román‐Curto, C., additional, and Cañueto, J., additional

Published
2022
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16. POSB48 Cost of Illness By Disease Stage of Patients with Mycosis Fungoides and Sézary Syndrome: A Real-World Analysis in Spanish Patients (Micados Study)

Author

Navarro Matilla, B, primary, Ortiz Romero, PL, additional, Pujol Vallverdú, RM, additional, Combalia Escudero, A, additional, Zapata Paz, I, additional, González Barca, E, additional, Muniesa Montserrat, C, additional, Morillo Andújar, M, additional, Pérez Ferriols, A, additional, Román Curto, C, additional, Fernández de Misa Cabrera, R, additional, Hospital Gil, M, additional, Marín Niebla, A, additional, Rios Rull, PJ, additional, de la Cruz, F, additional, Izu Belloso, RM, additional, Martín García-Sancho, A, additional, Parera Amer, ME, additional, Córdoba, R, additional, Ramón Quiles, MD, additional, Saus Carreres, A, additional, Del Campo García, R, additional, Machan, S, additional, Viguera Ester, P, additional, Blanco Garnelo, J, additional, Silva Romero, I, additional, and Soler López, B, additional

Published
2022
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22. Patients with primary cutaneous lymphoma are at risk for severe COVID‐19. Data from the Spanish Primary Cutaneous Lymphoma Registry

Author

Sánchez‐Velázquez, A., primary, Bauer‐Alonso, A., additional, Estrach, T., additional, Vega‐Díez, D., additional, Garcia‐Muret, P., additional, Haya, L., additional, Peñate, Y., additional, Acebo, E., additional, Fernández de Misa, R., additional, Blanes, M., additional, Suh‐Oh, H.J., additional, Izu, R., additional, Silva‐Díaz, E., additional, Sarriugarte, J., additional, Román‐Curto, C., additional, Botella‐Estrada, R., additional, Mateu‐Puchades, A., additional, Prieto‐Torres, L., additional, Morillas, V., additional, Morillo, M., additional, Sánchez‐Caminero, P., additional, Calzado, L., additional, Pérez-Ferriols, A., additional, Pérez, A., additional, Domínguez, J.D., additional, Navedo, M., additional, Muniesa, C., additional, Combalia, A., additional, Arroyo-Andrés, J., additional, Descalzo, M.A., additional, García-Doval, I., additional, and Ortiz-Romero, P.L., additional

Published
2021
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25. Characteristics and Clinical Implications of Carbapenemase-Producing Klebsiella pneumoniae Colonization and Infection, Italy

Author

Rossi, M, Chatenoud, L, Gona, F, Sala, I, Nattino, G, D'Antonio, A, Castelli, D, Itri, T, Morelli, P, Bigoni, S, Aldieri, C, Martegani, R, Grossi, P, Del Curto, C, Piconi, S, Rimoldi, S, Brambilla, P, Bonfanti, P, Van Hauwermeiren, E, Puoti, M, Gattuso, G, Cerri, C, Raviglione, M, Cirillo, D, Bandera, A, Gori, A, Rossi, Marianna, Chatenoud, Liliane, Gona, Floriana, Sala, Isabella, Nattino, Giovanni, D'Antonio, Alessia, Castelli, Daniele, Itri, Teresa, Morelli, Paola, Bigoni, Sara, Aldieri, Chiara, Martegani, Roberto, Grossi, Paolo A, Del Curto, Cecilia, Piconi, Stefania, Rimoldi, Sara G, Brambilla, Paola, Bonfanti, Paolo, Van Hauwermeiren, Evelyn, Puoti, Massimo, Gattuso, Gianni, Cerri, Chiara, Raviglione, Mario C, Cirillo, Daniela M, Bandera, Alessandra, Gori, Andrea, Rossi, M, Chatenoud, L, Gona, F, Sala, I, Nattino, G, D'Antonio, A, Castelli, D, Itri, T, Morelli, P, Bigoni, S, Aldieri, C, Martegani, R, Grossi, P, Del Curto, C, Piconi, S, Rimoldi, S, Brambilla, P, Bonfanti, P, Van Hauwermeiren, E, Puoti, M, Gattuso, G, Cerri, C, Raviglione, M, Cirillo, D, Bandera, A, Gori, A, Rossi, Marianna, Chatenoud, Liliane, Gona, Floriana, Sala, Isabella, Nattino, Giovanni, D'Antonio, Alessia, Castelli, Daniele, Itri, Teresa, Morelli, Paola, Bigoni, Sara, Aldieri, Chiara, Martegani, Roberto, Grossi, Paolo A, Del Curto, Cecilia, Piconi, Stefania, Rimoldi, Sara G, Brambilla, Paola, Bonfanti, Paolo, Van Hauwermeiren, Evelyn, Puoti, Massimo, Gattuso, Gianni, Cerri, Chiara, Raviglione, Mario C, Cirillo, Daniela M, Bandera, Alessandra, and Gori, Andrea

Abstract

Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp) has been endemic in Italy since 2013. In a multicenter cohort study, we investigated various aspects of KPC-Kp among patients, including 15-day mortality rates and delays in adequate therapy. Most (77%) KPC-Kp strains were sequence types ST512 or ST307. During 2017, KPC-Kp prevalence was 3.26 cases/1,000 hospitalized patients. Cumulative incidence of KPC-Kp acquired >48 hours after hospital admission was 0.68% but varied widely between centers. Among patients with mild infections and noninfected colonized patients, 15-day mortality rates were comparable, but rates were much higher among patients with severe infections. Delays of >4 days in receiving adequate therapy more frequently occurred among patients with mild infections than those with severe infections, and delays were less common for patients with known previous KPC-Kp colonization. Italy urgently needs a concerted surveillance system to control the spread of KPC-Kp.

Published
2021

33. 1091P Performance of Salamanca's refinement of the AJCC8 for T3 cutaneous squamous cell carcinoma (CSCC), versus the Brigham and Women's Hospital's alternative staging system and the Tübingen's alternative staging system for high-risk CSCC

Author

Puebla-Tornero, L., primary, Corchete-Sánchez, L., additional, Conde-Ferreirós, A., additional, García-Sancha, N., additional, Corchado-Cobos, R., additional, Cardeñoso-Álvarez, M.E., additional, Román-Curto, C., additional, and Cañueto, J., additional

Published
2020
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34. 1093P The features of the tumour microenvironment and the tumour budding identify prognostic subgroups in high-risk cutaneous squamous cell carcinoma

Author

Cañueto, J., primary, Mendiburu-Eliçade, M., additional, Corchete-Sánchez, L., additional, García-Sancha, N., additional, Corchado-Cobos, R., additional, Santos-Briz, Á., additional, Viñolas-Cuadros, A., additional, Cardeñoso-Álvarez, M.E., additional, Pérez-Losada, J., additional, and Román-Curto, C., additional

Published
2020
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35. Ther-PO-02 - Brentuximab vedotin in the treatment of cutaneous T-cell lymphomas: data from the Spanish Primary Cutaneous Lymphoma Registry

Author

Muniesa, C, Gallardo, F, García-Doval, I, Estrach, MT, Combalia, A, Morillo-Andújar, M, De la Cruz Vicente, F, Machan, S, Moya-Martínez, C, Rovira, R, Sanchez-Gonzalez, B, Acebo, E, Amutio, E, Peñate, Y, Losada-Castillo, MC, García-Muret, MP, Iznardo, H, Román-Curto, C, Cañueto, J, de Misa, R Fernández, Flórez, A, Izu, R, Torres-Navarro, I, Zayas, A, Pérez-Paredes, G, Blanes, M, Yanguas, JI, Pérez-Ferriols, A, Callejas-Charavia, M, Ortiz-Romero, PL, Pérez-Gil, A, Prieto-Torres, L, González-Barca, E, and Servitje, O

Published
2022
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36. Strategie per la rigenerazione dell'Albergheria

Author

PRESCIA, Renata, Lo Curto, C, Prescia, R., Lo Curto, C., PRESCIA, Renata, and Lo Curto, C

Subjects
rigenerazione, Albergheria, restauro, Settore ICAR/19 - Restauro
Abstract

Il saggio esplica l'importanza di azioni di 'partecipazione' attiva per la rigenerazione di un quartiere complesso del centro storico di Palermo, caratterizzato da una forte multiculturalità.

Published
2015

37. Postoperative radiotherapy provides better local control and long‐term outcome in selective cases of cutaneous squamous cell carcinoma with perineural invasion

Author

Cañueto, J., primary, Jaka, A., additional, Corchete, L.A., additional, González‐Pérez, A.Mª., additional, García‐Castro, R., additional, Fuente, Mª.J., additional, Membrive, I., additional, March, Á., additional, Mañes, A., additional, Posada, R., additional, Pujol, R.M., additional, Román‐Curto, C., additional, and Toll, A., additional

Published
2019
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38. Postoperative radiotherapy provides better local control and long‐term outcome in selective cases of cutaneous squamous cell carcinoma with perineural invasion.

Author

Cañueto, J., Jaka, A., Corchete, L.A., González‐Pérez, A.Mª., García‐Castro, R., Fuente, Mª.J., Membrive, I., March, Á., Mañes, A., Posada, R., Pujol, R.M., Román‐Curto, C., and Toll, A.

Subjects
SQUAMOUS cell carcinoma, SURGICAL site, COMPETING risks, RADIOTHERAPY, STATISTICAL significance
Abstract

Background: Perineural invasion (PNI) is a feature of poor prognosis in cutaneous squamous cell carcinoma (CSCC). The benefit of postoperative radiotherapy (PORT) in the management of CSCC with PNI is still not well established. Objectives: We aimed to evaluate the usefulness of PORT in the treatment of CSCC with PNI so as to determine which patients would best benefit from this type of treatment. Methods: A retrospective multicenter cohort of 110 CSCCs with PNI was evaluated. Eighteen recurrent cases were excluded for subsequent analysis. We searched for the types of PNI associated with poor outcome and analysed the effectiveness of PORT on different groups of CSCC with PNI. We also assessed for the usefulness of PORT depending on the surgical margin status (either clear or positive). Results: Postoperative radiotherapy showed clear benefit over observation in CSCC with PNI and positive margins after surgery, where the management by observation increased the risk of poor outcome events 2.43 times (P = 0.025), and especially in those with positive margins and PNI ≥0.1 mm, where the risk of poor prognosis is eight times greater following a management by observation (P = 0.0065). Multivariate competing risk analysis preserved statistical significance. Conclusions: The use of PORT on patients with CSCC with PNI and positive margins after surgery, especially in PNI ≥0.1 mm, significantly improves long‐term outcome. The benefit of PORT in cases with clear margins is not as evident, especially in those with PNI of small‐calibre nerves. Clinical trials are imperative. [ABSTRACT FROM AUTHOR]

Published
2020
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40. Micro RNA (miR)‐203 and miR‐205 expression patterns identify subgroups of prognosis in cutaneous squamous cell carcinoma

Author

Cañueto, J., primary, Cardeñoso‐Álvarez, E., additional, García‐Hernández, J.L., additional, Galindo‐Villardón, P., additional, Vicente‐Galindo, P., additional, Vicente‐Villardón, J.L., additional, Alonso‐López, D., additional, De Las Rivas, J., additional, Valero, J., additional, Moyano‐Sanz, E., additional, Fernández‐López, E., additional, Mao, J.H., additional, Castellanos‐Martín, A., additional, Román‐Curto, C., additional, and Pérez‐Losada, J., additional

Published
2017
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