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379 results on '"Curtis, Stephanie"'

1. Expanding the clinical spectrum of biglycan-related Meester-Loeys syndrome

Author

Meester, Josephina A. N., Hebert, Anne, Bastiaansen, Maaike, Rabaut, Laura, Bastianen, Jarl, Boeckx, Nele, Ashcroft, Kathryn, Atwal, Paldeep S., Benichou, Antoine, Billon, Clarisse, Blankensteijn, Jan D., Brennan, Paul, Bucks, Stephanie A., Campbell, Ian M., Conrad, Solène, Curtis, Stephanie L., Dasouki, Majed, Dent, Carolyn L., Eden, James, Goel, Himanshu, Hartill, Verity, Houweling, Arjan C., Isidor, Bertrand, Jackson, Nicola, Koopman, Pieter, Korpioja, Anita, Kraatari-Tiri, Minna, Kuulavainen, Liina, Lee, Kelvin, Low, Karen J., Lu, Alan C., McManus, Morgan L., Oakley, Stephen P., Oliver, James, Organ, Nicole M., Overwater, Eline, Revencu, Nicole, Trainer, Alison H., Trivedi, Bhavya, Turner, Claire L. S., Whittington, Rebecca, Zankl, Andreas, Zentner, Dominica, Van Laer, Lut, Verstraeten, Aline, and Loeys, Bart L.

Published
2024
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2. Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1.

Author

Malik, Nazma, Ferreira, Bibiana, Hollstein, Pablo, Curtis, Stephanie, Trefts, Elijah, Weiser Novak, Sammy, Yu, Jingting, Gilson, Rebecca, Hellberg, Kristina, Fang, Lingjing, Sheridan, Arlo, Hah, Nasun, Shadel, Gerald, Shaw, Reuben, and Manor, Uri

Subjects
AMP-Activated Protein Kinases, Lysosomes, Mitochondria, Organelle Biogenesis, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Phosphorylation, Protein Processing, Post-Translational, Humans
Abstract

Cells respond to mitochondrial poisons with rapid activation of the adenosine monophosphate-activated protein kinase (AMPK), causing acute metabolic changes through phosphorylation and prolonged adaptation of metabolism through transcriptional effects. Transcription factor EB (TFEB) is a major effector of AMPK that increases expression of lysosome genes in response to energetic stress, but how AMPK activates TFEB remains unresolved. We demonstrate that AMPK directly phosphorylates five conserved serine residues in folliculin-interacting protein 1 (FNIP1), suppressing the function of the folliculin (FLCN)-FNIP1 complex. FNIP1 phosphorylation is required for AMPK to induce nuclear translocation of TFEB and TFEB-dependent increases of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) and estrogen-related receptor alpha (ERRα) messenger RNAs. Thus, mitochondrial damage triggers AMPK-FNIP1-dependent nuclear translocation of TFEB, inducing sequential waves of lysosomal and mitochondrial biogenesis.

Published
2023

3. Healthcare-associated infections and antimicrobial use at a major referral hospital in Papua New Guinea: a point prevalence survey

Author

Thomas, Benjamin, Maingu, Cassius, Polly, Dellyne, Nogua, Hans, Mondowa, Jessica, Sokal, Joe, Yem, Josen, Lawrence, Joyce, Rarah, Mathilda, Olwont, Rose, Marcus, Rupert, Silas, Saberina, Kialo-Davis, Stephanie, Macintyre, Alison, Russo, Philip, Kehoe, Rosaleen, Curtis, Stephanie J., Barnabas, Roland, Cairns, Kelly A., Cameron, Donna, Coghlan, Benjamin, Jones, Robert, Joseph, Jacklyn, Kali, Alu, Kep, Dimitri, Klintworth, Gemma, Levy, Stephanie, Mason, Matt, Norrie, Majella, Peel, Trisha, Tamolsaian, Gilam, Telenge, Josephine, Tumu, Nellie, Stewardson, Andrew J., and Ak, Gabriella

Published
2024
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4. Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter

Author

Schmitt, Danielle L, Curtis, Stephanie D, Lyons, Anne C, Zhang, Jin-fan, Chen, Mingyuan, He, Catherine Y, Mehta, Sohum, Shaw, Reuben J, and Zhang, Jin

Subjects
Biochemistry and Cell Biology, Biological Sciences, Genetics, 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, AMP-Activated Protein Kinases, Cell Nucleus, Cytoplasm, Phosphorylation, Signal Transduction
Abstract

AMP-activated protein kinase (AMPK) is a master regulator of cellular energetics which coordinates metabolism by phosphorylating a plethora of substrates throughout the cell. But how AMPK activity is regulated at different subcellular locations for precise spatiotemporal control over metabolism is unclear. Here we present a sensitive, single-fluorophore AMPK activity reporter (ExRai AMPKAR), which reveals distinct kinetic profiles of AMPK activity at the mitochondria, lysosome, and cytoplasm. Genetic deletion of the canonical upstream kinase liver kinase B1 (LKB1) results in slower AMPK activity at lysosomes but does not affect the response amplitude at lysosomes or mitochondria, in sharp contrast to the necessity of LKB1 for maximal cytoplasmic AMPK activity. We further identify a mechanism for AMPK activity in the nucleus, which results from cytoplasmic to nuclear shuttling of AMPK. Thus, ExRai AMPKAR enables illumination of the complex subcellular regulation of AMPK signaling.

Published
2022

6. Transthoracic Echocardiographic Assessment of the Heart in Pregnancy—a position statement on behalf of the British Society of Echocardiography and the United Kingdom Maternal Cardiology Society

Author

Curtis, Stephanie L., Belham, Mark, Bennett, Sadie, James, Rachael, Harkness, Allan, Gamlin, Wendy, Thilaganathan, Baskaran, Giorgione, Veronica, Douglas, Hannah, Carroll, Aisling, Kitt, Jamie, Colebourn, Claire, Ribeiro, Isabel, Fairbairn, Sarah, Augustine, Daniel X., Robinson, Shaun, and Thorne, Sara A.

Published
2023
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7. Prevalence of pre-eclampsia and adverse pregnancy outcomes in women with pre-existing cardiomyopathy: a multi-centre retrospective cohort study

Author

Ormesher, Laura, Vause, Sarah, Higson, Suzanne, Roberts, Anna, Clarke, Bernard, Curtis, Stephanie, Ordonez, Victoria, Ansari, Faiza, Everett, Thomas R., Hordern, Claire, Mackillop, Lucy, Stern, Victoria, Bonnett, Tessa, Reid, Alice, Wallace, Suzanne, Oyekan, Ebruba, Douglas, Hannah, Cauldwell, Matthew, Reddy, Maya, Palmer, Kirsten, Simpson, Maggie, Brennand, Janet, Minns, Laura, Freeman, Leisa, Murray, Sarah, Mary, Nirmala, Castleman, James, Morris, Katie R., Haslett, Elizabeth, Cassidy, Christopher, Johnstone, Edward D., and Myers, Jenny E.

Published
2023
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8. An outdoor hotel quarantine facility model in Australia: best practice with optimal outcomes

Author

Curtis, Stephanie J., Trewin, Abigail, Mcdermott, Kathleen, Were, Karen, Walczynski, Tracy, Notaras, Len, and Walsh, Nick

Subjects
Epidemics -- Control -- Australia, Best practices -- Methods, Quarantine -- Buildings and facilities -- Models, Health
Abstract

: Objective: To describe the operationalisation of a novel outdoor quarantine facility managed by the Australian Medical Assistance Team, the Howard Springs International Quarantine Facility (HSIQF) at the Centre for National Resilience in the Northern Territory, Australia. Methods: We collated documentation and data from HSIQF to describe policies and procedures implemented and performed a descriptive analysis of key procedures and outcomes. Results: From 23 October 2020 to 31 March 2021, 2.2% (129/5,987) of residents were confirmed COVD‐19 cases. On average per day, 82 [Interquartile Range (IQR): 29‐95] staff completed personal protective equipment (PPE) training, 94 [IQR: 90‐104] staff completed antigen testing and 51 [IQR: 32‐136] staff completed polymerase chain reaction testing. The operation focused on building a safe environment with infection prevention and control adherence and workforce sustainability. There was no leakage of SARS‐CoV‐2 to staff or the community and no PPE compromises requiring staff to quarantine for 14 days. Conclusion: HSIQF demonstrates the operationalisation of an effective, safe and replicable quarantine system. Implications for public health: Quarantine is a critical public health tool for pandemic control. The HSIQF operations may be useful to inform the establishment and management of quarantine facilities for future and current disease outbreaks., International travel has driven global transmission of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Travel‐related control measures, including mandatory quarantine for returned travellers, were implemented early in the pandemic in [...]

Published
2022
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9. Rapid SARS-CoV-2 Seroprevalence Survey in Central and Western Divisions of Fjji, 2021

Author

Curtis, Stephanie J., Shah, Abdul W., Ratu, Ana, Wilson, Donald J., Hill, Philip C., Hulcome, Phil, Gaylard, Cathy, Faktaufon, Daniel, Cabemaiwai, Talica, Rabukawaqa, Isireli, Qoriniasi, Tevita, Narayan, Akesh, Nakalevu, Susana, Romakin, Pablo, Tudravu, Jemesa, Fong, James, and Walsh, Nick

Subjects
Epidemics -- Statistics -- Causes of -- Fiji, Health
Abstract

In Fiji, the SARS-CoV-2 Delta variant wave occurred in a largely unvaccinated and nonimmune population during April-November 2021 (1). A risk-based COVID-19 vaccine rollout strategy commenced in March 2021, and, [...]

Published
2023
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10. Cardiac implantable electronic devices in pregnancy: A position statement.

Author

Castleman, James, Curtis, Stephanie, Fox, Caroline, Hudsmith, Lucy, Nolan, Lynn, Geoghegan, James, Metodiev, Yavor, Roberts, Eleri, Morse, Lucy, Nisbet, Ashley, Foley, Paul, Wright, Ian, Thomas, Honey, Morris, Katie, Adamson, Dawn, and De Bono, Joseph

Subjects
*ELECTRONIC equipment, *IMPLANTABLE cardioverter-defibrillators, *MATERNAL mortality, *PUERPERIUM, *PREGNANCY
Abstract

The aim of this document is to provide guidance for the management of women and birthing people with a permanent pacemaker (PPM) or implantable cardioverter defibrillator (ICD). Cardiac devices are becoming more common in obstetric practice and a reference document for contemporary evidence‐based practice is required. Where evidence is limited, expert consensus has established recommendations. The purpose is to improve safety and reduce the risk of adverse events relating to implanted cardiac devices during pregnancy, birth and the postnatal period. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Injecting drug use is a risk factor for methicillin resistance in patients with Staphylococcus aureus bloodstream infections.

Author

Curtis, Stephanie J., Marvelianto Tedjo, Timothy, Lee, Sue J., Rawson‐Harris, Philip J., Sim, Kirsty, Attwood, Lucy O., Jenney, Adam W. J., and Stewardson, Andrew J.

Subjects
*RISK assessment, *STAPHYLOCOCCAL diseases, *INTRAVENOUS drug abuse, *HOSPITAL care, *MEDICAL care, *METHICILLIN-resistant staphylococcus aureus, *DESCRIPTIVE statistics, *RETROSPECTIVE studies, *LONGITUDINAL method, *SEPSIS, *COMPARATIVE studies, *CONFIDENCE intervals, *DISEASE risk factors
Abstract

We investigated whether injecting drug use was a risk factor for methicillin resistance among inpatients with Staphylococcus aureus bloodstream infections (SABSIs) at an Australian health service. In 273 inpatients, 46 (16.9%) of SABSIs were methicillin‐resistant S. aureus (MRSA). MRSA was more frequent in those who had injected drugs in the past 6 months (20.6%) compared with other inpatients (15.7%). Injecting drug use was associated with a 4.82‐fold (95% confidence interval = 1.54–16.29) increased odds of MRSA after accounting for confounders. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Prevalence and incidence of emergency department presentations and hospital separations with injecting-related infections in a longitudinal cohort of people who inject drugs

Author

Curtis, Stephanie J., primary, Colledge-Frisby, Samantha, additional, Stewardson, Andrew J., additional, Doyle, Joseph S., additional, Higgs, Peter, additional, Maher, Lisa, additional, Hickman, Matthew, additional, Stoové, Mark A., additional, and Dietze, Paul M., additional

Published
2023
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22. Contributors

Author

Albakri, Aref, primary, AlMahameed, Soufian T., additional, Andršová, Irena, additional, Asirvatham, Samuel J., additional, Avari Silva, Jennifer N., additional, Bacharova, Ljuba, additional, Bagliani, Giuseppe, additional, Barakat, Rody, additional, Barakat, Michel M., additional, Barletta, Valentina, additional, Barthel, Petra, additional, Bébarová, Markéta, additional, Beck, Hiroko, additional, Belhassen, Bernard, additional, Bende, Girish, additional, Berkefeld, Anna, additional, Birgersdotter-Green, Ulrika, additional, Blinova, Ksenia, additional, Blomström-Lundqvist, Carina, additional, Bongiorni, Maria Grazia, additional, Brand, Thomas, additional, Bugiardini, Raffaele, additional, Bunch, T. Jared, additional, Castiglione, Alessandro, additional, Cenko, Edina, additional, Chatzidou, Sofia, additional, Chee, Jennifer, additional, Chelu, Mihail G., additional, Chen, Shih Ann, additional, Ciconte, Giuseppe, additional, Curtis, Anne B., additional, Curtis, Stephanie, additional, Cygankiewicz, Iwona, additional, Dalal, Aarti S., additional, Day, John D., additional, Della Tommasina, Veronica, additional, Deshmukh, Abhishek J., additional, Dilaveris, Polychronis, additional, Di Summa, Roberto, additional, Dogan, Mehmet, additional, Dong, Jun, additional, du Fay de Lavallaz, Jeanne, additional, Eckhardt, Lee L., additional, Efimova, Elena, additional, Ernst, Sabine, additional, Fawzy, Ameenathul M., additional, Gaita, Fiorenzo, additional, Garber, Libet, additional, Garnett, Christine, additional, Georgiopoulos, Georgios, additional, Gillis, Anne M., additional, Giustetto, Carla, additional, Gonzalez Corcia, M. Cecilia, additional, Haim, Moti, additional, Halliday, Brian P., additional, Hamdan, Mohamed H., additional, Hammersley, Daniel J., additional, Hartikainen, Juha E.K., additional, Haugaa, Kristina H., additional, Haukilahti, M. Anette E., additional, Hautala, Arto J., additional, Helánová, Kateřina, additional, Hnatkova, Katerina, additional, Hu, Yu-Feng, additional, Hu, Xiao, additional, Hurley, David, additional, Iwai, Sei, additional, Jacobs, Victoria, additional, Jacobson, Jason T., additional, James, Cynthia A., additional, Jiang, Hongying, additional, Jones, Camelle, additional, Jones, Richard E., additional, Junttila, M. Juhani, additional, Kadish, Alan H., additional, Karavirta, Laura, additional, Karim, Saima, additional, Karnad, Dilip, additional, Karunatilleke, Anne, additional, Kaufman, Elizabeth S., additional, Kenttä, Tuomas V., additional, Kezerle, Louise, additional, Khalil, Fouad M., additional, Klingenheben, Thomas, additional, Kloosterman, M., additional, Kontogiannis, Christos, additional, Kowlgi, Gurukripa N., additional, Kroman, Anne M., additional, Kutyifa, Valentina, additional, Lampert, Rachel, additional, Laukkanen, Jari, additional, Lee, Hyon Jae, additional, Leinveber, Pavel, additional, Leren, Ida S., additional, Lima, Fabio V., additional, Linde, Cecilia, additional, Locati, Emanuela T., additional, Macfarlane, Peter W., additional, Maclachlan, Hamish, additional, Mäkikallio, Timo H., additional, Malik, Marek, additional, Manfrini, Olivia, additional, Marashly, Qussay, additional, Margioula, Eleni, additional, McCaffrey, James A., additional, Mehra, Nandini S., additional, Milman, Anat, additional, Moharem-Elgamal, Sarah, additional, Mujović, Nebojša, additional, Nagarajan, Darbhamulla V., additional, Nemec, Petr, additional, Novotný, Tomáš, additional, O'Neill, Louisa, additional, Odening, Katja E., additional, Panicker, Gopi Krishna, additional, Pappone, Carlo, additional, Patton, Kristen K., additional, Pelter, Michele M., additional, Peyracchia, Mattia, additional, Potpara, Tratjana, additional, Powell, Benjamin E., additional, Preben, Bjerregaard, additional, Sarkozy, Andrea, additional, Schneider, Birke, additional, Segreti, Luca, additional, Selzman, Kimberly A., additional, Sharma, Sanjay, additional, Šišáková, Martina, additional, Spears, D.A., additional, Spera, Francesco Raffaele, additional, Špinarová, Lenka, additional, Stein, Phyllis K., additional, Stergiopoulos, Kathleen, additional, Sticherling, Christian, additional, Stuart, Graham, additional, Sugrue, Alan M., additional, Svennberg, Emma, additional, Tada, Hiroshi, additional, Tampakis, Konstantinos, additional, Tereshchenko, Larisa G., additional, Terho, Henri, additional, te Riele, Anneline S.J.M., additional, Tikkanen, Jani T., additional, Toman, Ondřej, additional, Toso, Elisabetta, additional, Tracy, Cynthia M., additional, Trifunovic, Danijela, additional, Turner, James M.A., additional, Vaidya, Vaibhav R., additional, Van Gelder, Isabelle C., additional, Vasavan, Tharni, additional, Verrier, Richard L., additional, Veseli, Granit, additional, Vicente, Jose, additional, Williamson, Catherine, additional, Wu, Wendy W., additional, YH. Lip, Gregory, additional, Younis, Arwa, additional, Zabel, Markus, additional, Zathar, Zafraan, additional, Zegre-Hemsey, Jessica K., additional, Zheng, Nan, additional, and Zucchelli, Giulio, additional

Published
2020
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23. Nuclear Functions of AMP-Activated Protein Kinase

Author

Curtis, Stephanie Dara

Subjects
Molecular biology, Cellular biology, Biochemistry
Abstract

AMP-activated protein kinase (AMPK) is a master regulator of metabolism. AMPK senses when cellular (and organismal) energy levels are low, and orchestrates adaptive changes to metabolic pathways, cellular processes, and gene expression programs to restore energy balance in response. Due its central homeostatic function, AMPK represents an important signaling mode in many contexts of health and disease, and an intriguing target for therapeutic intervention in many metabolic diseases.Elucidating specific downstream effects of AMPK and its molecular effectors is key for understanding the role of AMPK activation in different health contexts. While many functions of AMPK have been identified, particularly cytosolically, AMPK’s function in the nuclear compartment has remained elusive. With growing evidence that AMPK has important effects on gene expression, this work aims to illuminate nuclear AMPK activity: Here we examine its nuclear localization, nuclear targets, and transcription factor effectors of AMPK activation.Using a nuclear proteomics approach, we found that AMPKα1 shuttles into the nucleus following activation. We evaluated the upstream signals of this effect and found that an LKB1-dependent pathway is involved in response to both allosteric activation and mitochondrial stress. We performed a bioinformatics screen of transcription factors to identify potential direct targets of AMPK in the nucleus and validated the novel substrate SRF and several AMPK-SRF-dependent genes. Further, we optimized a biochemical approach for the identification of additional nuclear substrates.In addition to these protein-level studies, we perform transcript-level analyses. Major known effectors of AMPK-dependent transcription are the transcription factors TFEB and TFE3 (TFEB/3). Previous work has shown that transcription factors induced by TFEB/3 can be critical adaptive mediators of transcription downstream of AMPK activation. We searched for other possible key secondary effectors of transcriptional cascades downstream of AMPK-TFEB/3 by gene expression analysis and identified five transcription factors of interest which behave as AMPK-dependent TFEB/3 target genes: CREBRF, CREBL2, KLF9, KLF11, and KLF15.This combination of biochemical approaches, proteomic strategies, gene editing, RNA-sequencing, and bioinformatics analysis has culminated in the characterization of multiple aspects of nuclear AMPK activity, the identification of a novel nuclear substrate, and insights into AMPK-mediated transcriptional rewiring.

Published
2021

35. sj-docx-1-jpx-10.1177_23743735231183669 - Supplemental material for Telehealth for Comprehensive Care to Quarantine Residents: A Novel Approach and Lessons Learned

Author

Curtis, Stephanie J., Taylor, Ronnie, Perry, Lynette, Trewin, Abigail, Were, Karen, Walsh, Nick, and McDermott, Kathleen

Subjects
111708 Health and Community Services, Medicine, FOS: Health sciences
Abstract

Supplemental material, sj-docx-1-jpx-10.1177_23743735231183669 for Telehealth for Comprehensive Care to Quarantine Residents: A Novel Approach and Lessons Learned by Stephanie J. Curtis, Ronnie Taylor, Lynette Perry, Abigail Trewin, Karen Were, Nick Walsh and Kathleen McDermott in Journal of Patient Experience

Published
2023
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37. Analysing functional implications of differences in left ventricular morphology using statistical shape modelling

Author

Froso Sophocleous, Lucy Standen, Doolub, Gemina D., Reem Laymouna, Chiara Bucciarelli-Ducci, Massimo Caputo, Manghat, Nathan E., Hamilton, Mark C. K., Curtis, Stephanie L., and Giovanni Biglino

Subjects
Multidisciplinary, Bicuspid Aortic Valve Disease, Aortic Valve, Heart Ventricles, Humans, Coenzyme A, Aorta, Aortic Coarctation, Ventricular Function, Left
Abstract

Functional implications of left ventricular (LV) morphological characterization in congenital heart disease are not widely explored. This study qualitatively and quantitatively assessed LV shape associations with a) LV function and b) thoracic aortic morphology in patients with aortic coarctation (CoA) with/without bicuspid aortic valve (BAV), and healthy controls. A statistical shape modelling framework was employed to analyse three-dimensional (3D) LV shapes from cardiac magnetic resonance (CMR) data in isolated CoA (n = 25), CoA + BAV (n = 30), isolated BAV (n = 30), and healthy controls (n = 25). Average 3D templates and deformations were computed. Correlations between shape data and CMR-derived morphometric parameters (i.e., sphericity, conicity) or global and apical strain values were assessed to elucidate possible functional implications. The relationship between LV shape features and arch architecture was also explored. The LV template was shorter and more spherical in CoA patients. Sphericity was overall associated with global and apical radial (p = 0.001, R2 = 0.09; p 2 = 0.17) and circumferential strain (p = 0.001, R2 = 0.10; p = 0.04, R2 = 0.04), irrespective of the presence of aortic stenosis and/or regurgitation and controlling for age and hypertension status. LV strain was not associated with arch architecture. Differences in LV morphology were observed between CoA and BAV patients. Increasing LV sphericity was associated with reduced strain, independent of aortic arch architecture and functional aortic valve disease.

Published
2022
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38. Avoiding Catastrophe in a High-Risk Environment: AUSMAT at Howard Springs

Author

Trewin, Abigail, Curtis, Stephanie J, McDermott, Kathleen, Were, Karen, and Walsh, Nick

Subjects
General Medicine, COVID-19, quarantine, emergencies, Disease Outbreaks, Medical Assistance
Abstract

The Australian Medical Assistance Team (AUSMAT) led the implementation, establishment and management of Howard Springs International Quarantine Facility at the Centre for National Resilience from October 2020 to May 2021. The operation is internationally renowned for its success to mitigate leakage of the coronavirus disease from the quarantine facility to the community during a national policy of virus elimination or suppression. The operations success led to other Australian jurisdictions seeking to replicate the quarantine model. Here, we use three theoretical frameworks to describe AUSMATs approach to risk mitigation at the quarantine facility.

Published
2022
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50. Left Ventricular Morphology in Patients with Aortic Coarctation and Bicuspid Aortic Valve: Novel Insights from a Statistical Shape Modelling Framework

Author

Sophocleous, Froso, primary, Standen, Lucy, additional, Doolub, Gemina, additional, Laymouna, Reem, additional, Bucciarelli-Ducci, Chiara, additional, Caputo, Massimo, additional, Manghat, Nathan, additional, Hamilton, Mark, additional, Curtis, Stephanie, additional, and Biglino, Giovanni, additional

Published
2022
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