129 results on '"Curtin F"'
Search Results
2. Adverse Drug Reactions Due to Opioid Use in Oldest-Old Patients Visiting the Emergency Unit of the Geneva Geriatric Hospital
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Ing Lorenzini, K., primary, Wainstein, L., additional, Curtin, F., additional, Trombert, V., additional, Zekry, D., additional, Gold, G., additional, Piguet, V., additional, and Desmeules, J., additional
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- 2022
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3. Prevalence of Anal Incontinence and Other Anorectal Symptoms in Women
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Faltin, D. L., Sangalli, M. R., Curtin, F., Morabia, A., and Weil, A.
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- 2001
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4. Effects of smoking and smoking cessation on dietary habits of a Swiss urban population
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Morabia, A, Curtin, F, and Bernstein, MS
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- 1999
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5. Association between beta-blockers, other antihypertensive drugs and psoriasis: population-based case–control study
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Brauchli, Y. B., Jick, S. S., Curtin, F., and Meier, C. R.
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- 2008
6. Antipsychotics and risk of venous thrombosis
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Curtin, F. and Blum, M.
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- 2002
7. Relation of Environmental Tobacco Smoke to Diet and Health Habits: Variations According to the Site of Exposure
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Curtin, F, Morabia, A, and Bernstein, M.S
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- 1999
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8. Review of Port Financial Accounts: Review of Irish Semi-State Port Companies Financial Accounts
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Murphy, G., Curtin, F., Spray, M., and Richardson, B.
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IMDO - Abstract
The focus of this analysis is to extrapolate key data from the annual company financial reports in order to provide a comparative review of the ports. The nine semi state port companies reviewed are all under the auspices of the Minister for Transport, Tourism and Sport. The key findings of the report highlight that after a combined growth of 3% in turnover in 2010, the nine commercial ports recorded a fall in turnover of 3% in 2011 with turnover falling to €120m. The cost of sales remained relatively unchanged at €46.9 million. Despite the downturn last year, five of the ports managed to return profits which contributed to a total operating profit for the industry of €33 million, almost identical to 2010, with four ports recording operating losses totalling €353,640. Dublin Port generated 57% of the total share of turnover, up 3% from 2011, while it was responsible for contributing 83% of the total operating profits from the nine ports last year. Dublin and Cork, contributed a dividend to the State in the financial accounts for 2011 of 16.5million and €634,315 respectively. Galway has also announced their intention to pay a dividend in their 2012 accounts. The latest analysis carried out by the IMDO also suggests that the majority of ports continued to reduce their costs during 2011. Labour costs fell by 8% last year, largely as a result of further reductions in the number of port employees from 429 to 389, which included a reduction of 11 employees as a result of the rationalisation of Dundalk Port Company. The total port labour force has now reduced by 26% since 2007. Eight of the nine companies recorded lower total labour operating costs in 2011. The average return on capital employed (ROCE) increased to 2.44% last year. However only three of the nine ports provided a ROCE higher than the average, with Dublin Port highest at just over 10%. The IMDO believes that trading conditions at Irish ports will remain challenging for the financial year 2012 with no anticipated prospects for overall growth in the principal cargo segments. The openness of the Irish economy will mean that any near to medium term recovery in traffic growth through Irish ports is likely to be dependent on a wider recovery occurring in the European and Global economy. Our forecast is that overall turnover and profits for the Irish ports will fall this year. However we still expect that the larger commercial ports will remain profitable while smaller regional ports are less likely to achieve breakeven levels this year. The review, assumptions and opinions expressed within this report are exclusively those of the IMDO., Funder: Irish Maritime Development Office (IMDO)
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- 2012
9. Book reviews
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Fitzgerald, Patrick, Curtin, F., Dean, Geoffrey, Breathnach, C. S., Shanahan, R., Legge, David, and Browne, A. D. H.
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- 1975
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10. Clinical experience with diffusion-weighted MR in patients with acute stroke
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Ko, Lövblad, Hj, Laubach, Ae, Baird, Curtin F, Schlaug G, Rr, Edelman, and Warach S
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Adult ,Aged, 80 and over ,Male ,Neurologic Examination ,Echo-Planar Imaging ,Comment ,Brain ,Cerebral Infarction ,Middle Aged ,Image Enhancement ,Sensitivity and Specificity ,Brain Ischemia ,Diffusion ,Acute Disease ,Journal Article ,Humans ,Female ,Aged - Abstract
PURPOSE: Our purpose was to evaluate the clinical efficacy, sensitivity, and specificity of echo-planar diffusion-weighted MR imaging in patients with acute infarction. METHODS: We retrospectively analyzed 194 cases of acute ischemic stroke diagnosed clinically within 24 hours of onset and studied with echo-planar diffusion-weighted MR imaging. Examinations were considered to be positive for infarction when an increase in signal was noted on images acquired at a high b value but absent on images with a low b value. A final clinical diagnosis of acute stroke was used as the standard of reference. A subset of 48 patients scanned within 6 hours was also analyzed. RESULTS: Diffusion-weighted MR imaging studies were positive in 133 of 151 cases of infarction (88% sensitivity) and negative in 41 of 43 cases with no infarction (95% specificity). Two cases identified as positive on diffusion-weighted images had nonischemic diagnoses (1.5% false-positive rate). Diffusion-weighted imaging had a positive predictive value of 98.5% and a negative predictive value of 69.5%. Use of T2-weighted sequences as well as diffusion-weighted imaging produced no false-positive findings. Of the negative scans, 69.5% corresponded to transient ischemic attacks or infarcts (mostly small brain stem infarcts). When only cases scanned within 6 hours of onset were considered, the sensitivity rose to 94% and the specificity to 100%. CONCLUSION: Despite bias due to dependence between diffusion-weighted imaging and the final diagnosis, this analysis suggests high sensitivity and specificity for echo-planar diffusion-weighted imaging in the diagnosis of acute cerebral infarction, although negative scans did not rule out an ischemic pathogenesis.
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- 1998
11. Multiple sclerosis—new chances?
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Curtin, F., primary
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- 2013
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12. Making Glass-Fiber-Reinforced Coolant Tubes
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Curtin, F
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Fabrication Technology - Abstract
New use found for heat-shrinkable sleeves. Smooth, noncontaminating channels for transporting cooling water in Space Shuttle Extravehicularmobility unit made of fiberglass tubing with aid of heat-shrinkable sleeves. Previously, glass fibers from inner walls of tubes contaminate water.
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- 1985
13. Book reviews
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Curtin, F., Breathnach, C. S., Walsh, N., and Weir, D. G.
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- 1975
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14. 4.6 Sovereignty panelRapporteur: Fiona Curtin. Participants: 300
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CURTIN, F, primary
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- 2001
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15. Lifetime Exposure to Environmental Tobacco Smoke among Urban Women: Differences by Socioeconomic Class
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Curtin, F., primary, Morabia, A., additional, and Bernstein, M., additional
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- 1998
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16. A population survey of bowel habits in urban Swiss men
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Curtin, F, primary
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- 1998
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17. Day-to-day intraindividual reliability and interindividual differences in monoamines excretion
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Curtin, F, primary
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- 1996
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18. 4-Oxalocrotonate tautomerase, an enzyme composed of 62 amino acid residues per monomer.
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Chen, L.H., primary, Kenyon, G.L., additional, Curtin, F, additional, Harayama, S, additional, Bembenek, M.E., additional, Hajipour, G, additional, and Whitman, C.P., additional
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- 1992
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19. Relation of BMI to a dual-energy X-ray absorptiometry measure of fatness.
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Morabia A, Ross A, Curtin F, Pichard C, and Slosman DO
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- 1999
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20. Relation of Environmental Tobacco Smoke to Diet and Health Habits - Comparison of exposure levels, sources of exposures, validity and perception
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Curtin, F., Morabia, A., and Bernstein, M.S.
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- 1999
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21. Body Mass Index Compared to Dual-Energy X-Ray Absorptiometry: Evidence for a Spectrum Bias
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Curtin, F., Morabia, A., Pichard, C., and Slosman, D. O.
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- 1997
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22. Psychosocial Profile of Swiss Sexual Offenders
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Curtin, F and Niveau, G
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Background data on psychosocial characteristics of sexual offenders are sparse in Europe. From 67 experts' reports done between 1982 and 1995 in Geneva, Switzerland, demographic, criminological and psychiatric characteristics were collected for three groups of sexual offenders: offenders against adults, offenders against non-relative minors (<18 yr), and offenders against minors with incest. The results showed that the offenders against adults were younger (p= 0.02), more frequently single 9p= 0.0007) and with a lower educational level (p= 0.05) than the offenders against minors. Incest offenders had no prior conviction compared with 50% of the other offenders. Violence was more often used by offenders against adults (86%) than by offenders against minors (45%) (p= 0.005). About two-thirds of the sexual offenders had no psychiatric history, but a personality disorder (mainly borderline) was diagnosed in half of the offenders. A history of sexual abuse during childhood was reported by a third of the offenders against minors and by 5% of the offenders against adults (p= 0.04).It is concluded that a low socio-economic status and social isolation characterized offenders against adults, whereas offenders against minors had a relatively normal psychosocial profile.
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- 1998
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23. Reward Dependence is Positively Related to Urinary Monoamines in Normal Men
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Curtin, F., Walker, J.-P., Peyrin, L., Soulier, V., Badan, M., and Schulz, P.
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- 1997
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24. 4.6 Sovereignty panel
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Curtin, F
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- 2001
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25. Do selective serotonin reuptake inhibitors cause suicide? [1] (multiple letters)
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Curtin, F., Schulz, P., Healy, D., Gunnell, D., Saperia, J., Ashby, D., Jones, H. M., Sakinofsky, I., Strelner, D. L., Alex Mitchell, Fergusson, D., Doucette, S., Hebert, P., Shapiro, S., Raven, M. K., Cipriani, A., Barbui, C., Geddes, J. R., Murray, M. L., Wong, I. C. K., and Thompson, M.
26. Pulmonary Scintiangiography in the Diagnosis of Thromboembolism
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EVANS, GEORGE W., primary, KIERAN, JAMES H., additional, WILLIAMSON, SHEILA M., additional, McCARTHY, HUGH F., additional, CURTIN, F GREGORY, additional, and HINNENDAEL, FRANCIS H., additional
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- 1977
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27. Multiple Correlations and Bonferroni's Correction
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Curtin, F. and Schulz, P.
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- 1998
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28. Scintigraphy in Traumatic Lesions of Liver and Spleen
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Evans, George W., Curtin, F. Gregory, McCarthy, Hugh F., and Kieran, James H.
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Simultaneous splenic and hepatic scintigrams were performed with technetium Tc 99m colloid on 19 patients who had sustained abdominal trauma. Five cases of splenic hematoma were diagnosed; all were confirmed and successfully treated. Three cases of liver hematoma were diagnosed; two were confirmed, and all were successfully managed. There is no evidence that the procedure failed to detect clinically significant lesions of the liver or the spleen.
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- 1972
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29. Prevention of relapse in schizophrenia.
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Curtin F, Stalman SLP, Lieberman J, Stroup S, Csernansky JG, and Mahmoud R
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- 2002
30. The relations between scores on analogous scales from four personality questionnaires in 50 normal men
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Curtin, F., Walker, J.-P., Badan, M., and Schulz, P.
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- 1995
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31. Use of selective serotonin reuptake inhibitors in childhood depression.
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Wohlfarth T, Lekkerkerker F, van Zwieten B, Curtin F, Schulz P, Salerian AJ, Whittington CJ, Kendall T, Fonagy P, Cottrell D, and Cotgrove A
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- 2004
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32. Antiviral Use in Mild-to-Moderate SARS-CoV-2 Infections during the Omicron Wave in Geriatric Patients.
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Exquis N, Dionisi B, Samer CF, Rollason V, Curtin F, Zekry D, Graf C, Prendki V, and Ing Lorenzini K
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- Humans, Female, Male, Aged, 80 and over, Retrospective Studies, Aged, COVID-19 virology, Adenosine analogs & derivatives, Antiviral Agents therapeutic use, Antiviral Agents adverse effects, COVID-19 Drug Treatment, Alanine analogs & derivatives, Alanine therapeutic use, Alanine adverse effects, Adenosine Monophosphate analogs & derivatives, Adenosine Monophosphate therapeutic use, Adenosine Monophosphate adverse effects, SARS-CoV-2 drug effects, Ritonavir therapeutic use, Ritonavir adverse effects, Drug Interactions
- Abstract
(1) Background: Geriatric patients are at high risk of complications of Coronavirus disease-2019 (COVID-19) and are good candidates for antiviral drugs. (2) Methods: A retrospective study of electronic health records (EHRs) aiming to describe antiviral (nirmatrelvir and ritonavir (nirmatrelvir/r) or remdesivir) use, drug-drug interactions (DDIs) and adverse drug reactions (ADRs) in elderly patients (75 and over), hospitalized with mild-to-moderate COVID-19 between July 2022 and June 2023. (3) Results: Out of 491 patients (mean age: 86.9 years), 180 (36.7%) received nirmatrelvir/r, 78 (15.9%) received remdesivir, and 233 (47.4%) received no antiviral therapy. No association was found between the choice of antiviral and the demographic or medical data. No serious ADR was observed. Nirmatrelvir/r dosage adjustment was inadequate in 65% of patients with renal impairment. In total, 128 patients (71%) on nirmatrelvir/r had potential pharmacokinetic DDIs, with 43 resulting in a possibly related ADR. In the remdesivir group, pharmacodynamic DDIs were more frequent, with QTc prolongation risk in 56 patients (72%). Only 20 patients underwent follow-up ECG, revealing QTc prolongation in 4. (4) Conclusions: There is an underutilization of antivirals despite their justified indications. Nirmatrelvir/r dosage was rarely adjusted to renal function. Dose adjustments and closer monitoring are needed due to the high risk of drug interactions.
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- 2024
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33. Evaluation of Pupillometry for CYP2D6 Phenotyping in Children Treated with Tramadol.
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Rodieux F, Storelli F, Curtin F, Manzano S, Gervaix A, Posfay-Barbe KM, Desmeules J, Daali Y, and Samer CF
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Following the contraindication of codeine use in children, increasing use of tramadol has been observed in pain management protocols. However, tramadol's pharmacokinetics (PK) and pharmacodynamics are influenced by cytochrome P450 (CYP)2D6 activity, similarly to codeine. Previous studies in adults have demonstrated a correlation between pupillary response and tramadol PK. Our objective was to evaluate pupillometry as a phenotyping method to assess CYP2D6 activity in children treated with tramadol. We included 41 children (mean age 11 years) receiving a first dose of tramadol (2 mg/kg) in the emergency room (ER) as part of their routine care. CYP2D6 phenotyping and genotyping were performed. The concentrations of tramadol and its active metabolite, M1, were measured, and static and dynamic pupillometry was conducted using a handheld pupillometer at the time of tramadol administration and during the ER stay. Pupillometric measurements were obtained for 37 children. Tramadol affected pupillary parameters, with a decrease in pupil diameter in 83.8% of children ( p = 0.002) (mean decrease 14.1 ± 16.7%) and a decrease in reflex amplitude constriction in 78.4% ( p = 0.011) (mean decrease 17.7 ± 34.5%) at T150 compared to T0. We were unable to identify a correlation between pupillometry measurements and CYP2D6 activity. Likely confounding factors include light intensity, pain, and stress, making the procedure less feasible in paediatric emergency settings.
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- 2023
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34. Medical cannabinoids for painful symptoms in patients with severe dementia: a randomized, double-blind cross-over placebo-controlled trial protocol.
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Bianchi F, Pautex S, Wampfler J, Curtin F, Daali Y, Desmeules JA, and Broers B
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Background: In an observational study in Geneva (Switzerland), we found that administering a standardized THC/CBD oil was feasible, safe, and beneficial in an elderly polymedicated population with severe dementia, behavioral troubles, and pain. Those findings need to be confirmed in a randomized clinical trial., Objectives: The MedCanDem trial is a randomized, double-blind cross-over placebo-controlled trial to study the efficacy of cannabinoids in improving painful symptoms during severe dementia disorders in patients living in long-term care facilities in Geneva. This manuscript describes the MedCanDem trial protocol., Materials and Methods: Participants will be patients suffering from severe dementia associated with pain and behavioral troubles and living in long-term care facilities. We selected five facilities specialized in caring for severely demented patients in Geneva (Switzerland). A total of 24 subjects will be randomized 1:1 to the sequence study intervention/placebo or the sequence placebo/study intervention. Patients will receive study intervention treatment or placebo for eight weeks, and then after a one-week wash-out, treatments will be inversed for another eight weeks. The intervention will be a standardized THC/CBD 1:2 oil extract, and the placebo will be a hemp seed oil. The primary outcome is the reduction from the baseline of the Cohen-Mansfield score; secondary outcomes include the reduction in the Doloplus scale, the reduction of rigidity, the monitoring of concomitant drugs prescription and de-prescription, the safety assessment, and a pharmacokinetic evaluation. The primary and secondary outcomes will be assessed at the baseline, after 28 days, and at the end of both study periods. In addition, safety laboratory analysis, pharmacokinetic evaluation, and therapeutic drug monitoring for the cannabinoids will be evaluated through a blood sample analysis conducted at the beginning and the end of both study periods., Discussion and Conclusion: This study will allow us to confirm the clinical results observed during the observational study. It represents one of the few studies aiming to prove natural medical cannabis efficacy in a population of non-communicating patients with severe dementia, experimenting with behavioral troubles, pain, and rigidity., Trial Registration: The trial has Swissethics authorization (BASEC 2022-00999), and it is registered on clinicaltrials.gov (NCT05432206) and the SNCTP (000005168)., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2023 Bianchi, Pautex, Wampfler, Curtin, Daali, Desmeules and Broers.)
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- 2023
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35. Is massage a legitimate part of nursing care? A qualitative study.
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Da Rocha Rodrigues G, Anex A, Boegli M, Bollondi Pauly C, Curtin F, Luthy C, Desmeules J, and Cedraschi C
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- Humans, Qualitative Research, Massage, Internal Medicine, Chronic Pain, Nursing Care
- Abstract
Introduction: The use of massage therapy has received increased attention in the treatment of chronic pain. However, barriers can hinder its use in nursing care. This study uses a qualitative methodology to explore professionals' experiences regarding touch massage (TM) and identify barriers and facilitators for the implementation of this intervention., Materials and Methods: This study is part of a larger research program aimed at investigating the impact of TM on the experiences of patients with chronic pain hospitalized in two units of an internal medicine rehabilitation ward. Health care professionals (HCPs) were trained either to provide TM or to use of a massage-machine device according to their units. At the end of the trial, two focus groups were conducted with HCPs from each unit who took part in the training and agreed to discuss their experience: 10 caregivers from the TM group and 6 from the machine group. The focus group discussions were tape-recorded, transcribed and analyzed using thematic content analysis., Results: Five themes emerged from thematic content analysis: perceived impact on patients, HCPs' affective and cognitive experiences, patient-professionals relationships, organizational tensions, and conceptual tensions. Overall, the HCPs reported better general outcomes with TM than with the machine. They described positive effects on patients, HCPs, and their relationships. Regarding interventions' implementation, the HCPs reported organizational barriers such as patients' case complexity, work overload, and lack of time. Conceptual barriers such as ambivalence around the legitimacy of TM in nursing care were reported. TM was often described as a pleasure care that was considered a complementary approach and was overlooked despite its perceived benefits., Conclusion: Despite the perceived benefits of TM reported by the HCPs, ambivalence arose around the legitimacy of this intervention. This result emphasizes the importance of changing HCPs' attitudes regarding a given intervention to facilitate its implementation., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2023 Da Rocha Rodrigues et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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- 2023
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36. Carotid plaque surface echogenicity predicts cerebrovascular events: An Echographic Multicentric Swiss Study.
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Sztajzel RF, Engelter ST, Bonati LH, Mono ML, Slezak A, Kurmann R, Nedeltchev K, Gensicke H, Traenka C, Baumgartner RW, Bonvin C, Hirt L, Medlin F, Burow A, Kägi G, Kapauer M, Vehoff J, Lovblad KO, Curtin F, and Lyrer PA
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- Humans, Constriction, Pathologic, Pilot Projects, Switzerland epidemiology, Risk Factors, Ultrasonography, Carotid Stenosis diagnostic imaging, Ischemic Attack, Transient diagnostic imaging, Plaque, Atherosclerotic diagnostic imaging, Stroke diagnostic imaging
- Abstract
Background and Purpose: To determine the prognostic value for ischemic stroke or transitory ischemic attack (TIA) of plaque surface echogenicity alone or combined to degree of stenosis in a Swiss multicenter cohort METHODS: Patients with ≥60% asymptomatic or ≥50% symptomatic carotid stenosis were included. Grey-scale based colour mapping was obtained of the whole plaque and of its surface defined as the regions between the lumen and respectively 0-0.5, 0-1, 0-1.5, and 0-2 mm of the outer border of the plaque. Red, yellow and green colour represented low, intermediate or high echogenicity. Proportion of red color on surface (PRCS) reflecting low echogenictiy was considered alone or combined to degree of stenosis (Risk index, RI)., Results: We included 205 asymptomatic and 54 symptomatic patients. During follow-up (median/mean 24/27.7 months) 27 patients experienced stroke or TIA. In the asymptomatic group, RI ≥0.25 and PRCS ≥79% predicted stroke or TIA with a hazard ratio (HR) of respectively 8.7 p = 0.0001 and 10.2 p < 0.0001. In the symptomatic group RI ≥0.25 and PRCS ≥81% predicted stroke or TIA occurrence with a HR of respectively 6.1 p = 0.006 and 8.9 p = 0.001. The best surface parameter was located at 0-0.5mm. Among variables including age, sex, degree of stenosis, stenosis progression, RI, PRCS, grey median scale values and clinical baseline status, only PRCS independently prognosticated stroke (p = 0.005)., Conclusion: In this pilot study including patients with at least moderate degree of carotid stenosis, PRCS (0-0.5mm) alone or combined to degree of stenosis strongly predicted occurrence of subsequent cerebrovascular events., (© 2022 The Authors. Journal of Neuroimaging published by Wiley Periodicals LLC on behalf of American Society of Neuroimaging.)
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- 2022
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37. Cannabinoids for behavioral symptoms in severe dementia: Safety and feasibility in a long-term pilot observational study in nineteen patients.
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Pautex S, Bianchi F, Daali Y, Augsburger M, de Saussure C, Wampfler J, Curtin F, Desmeules J, and Broers B
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Context: The management of behavioral symptoms and rigidity in patients with dementia constitutes a significant challenge. Short-term studies suggest an interest in the use of medical cannabis, but long-term data are lacking., Objectives: The objective of this study was to investigate the feasibility and long-term safety of administering tetrahydrocannabinol/cannabidiol (THC/CBD) treatment as an additional drug to a poly medicated population with severe dementia, evaluate clinical improvements, and collect information on the pharmacokinetics of cannabinoids and possible drug-drug interactions., Methods: A prospective observational study of patients with severe dementia living in a long-term care home to whom the physicians had prescribed a medical cannabis treatment. Data were collected over 2 years. We assessed the changes in medical cannabis dosages, safety parameters, variations in neuropsychiatric problems, agitation, rigidity, the most invalidating daily activity, and disabling behavior trouble scores. We evaluated the pharmacokinetics of cannabinoids by measuring plasma levels and analyzing the enzymatic activity., Results: We assessed 19 patients (81.4 years-17 women and two men) receiving an average of 12.4 mg THC/24.8 mg CBD per day for up to 13 months, with no reported problems related to the treatment and limited adverse drug reactions. Clinical scores showed a marked improvement that was stable over time, deprescription of other medications, and care facilitated. The pharmacokinetic evaluation showed an expected slight reduction in the enzymatic activity of CYP1A2 and CYP2C19., Conclusion: A long-term THC/CBD (1:2) medication can be administered safely and with overall positive clinical improvement to poly medicated older adults with severe dementia and associated problems. The results must be confirmed in a randomized trial., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Pautex, Bianchi, Daali, Augsburger, de Saussure, Wampfler, Curtin, Desmeules and Broers.)
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- 2022
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38. Efficacy and safety of temelimab in multiple sclerosis: Results of a randomized phase 2b and extension study.
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Hartung HP, Derfuss T, Cree BA, Sormani MP, Selmaj K, Stutters J, Prados F, MacManus D, Schneble HM, Lambert E, Porchet H, Glanzman R, Warne D, Curtin F, Kornmann G, Buffet B, Kremer D, Küry P, Leppert D, Rückle T, and Barkhof F
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- Double-Blind Method, Gene Products, env therapeutic use, Humans, Magnetic Resonance Imaging, Treatment Outcome, Antibodies, Monoclonal, Humanized adverse effects, Antibodies, Monoclonal, Humanized therapeutic use, Multiple Sclerosis drug therapy, Multiple Sclerosis, Relapsing-Remitting diagnostic imaging, Multiple Sclerosis, Relapsing-Remitting drug therapy, Multiple Sclerosis, Relapsing-Remitting pathology
- Abstract
Background: The envelope protein of human endogenous retrovirus W (HERV-W-Env) is expressed by macrophages and microglia, mediating axonal damage in chronic active MS lesions., Objective and Methods: This phase 2, double-blind, 48-week trial in relapsing-remitting MS with 48-week extension phase assessed the efficacy and safety of temelimab; a monoclonal antibody neutralizing HERV-W-Env. The primary endpoint was the reduction of cumulative gadolinium-enhancing T1-lesions in brain magnetic resonance imaging (MRI) scans at week 24. Additional endpoints included numbers of T2 and T1-hypointense lesions, magnetization transfer ratio, and brain atrophy. In total, 270 participants were randomized to receive monthly intravenous temelimab (6, 12, or 18 mg/kg) or placebo for 24 weeks; at week 24 placebo-treated participants were re-randomized to treatment groups., Results: The primary endpoint was not met. At week 48, participants treated with 18 mg/kg temelimab had fewer new T1-hypointense lesions ( p = 0.014) and showed consistent, however statistically non-significant, reductions in brain atrophy and magnetization transfer ratio decrease, as compared with the placebo/comparator group. These latter two trends were sustained over 96 weeks. No safety issues emerged., Conclusion: Temelimab failed to show an effect on features of acute inflammation but demonstrated preliminary radiological signs of possible anti-neurodegenerative effects. Current data support the development of temelimab for progressive MS., Trial Registration: CHANGE-MS: ClinicalTrials.gov: NCT02782858, EudraCT: 2015-004059-29; ANGEL-MS: ClinicalTrials.gov: NCT03239860, EudraCT: 2016-004935-18.
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- 2022
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39. Genetic Susceptibility Toward Nausea and Vomiting in Surgical Patients.
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Gloor Y, Czarnetzki C, Curtin F, Gil-Wey B, Tramèr MR, and Desmeules JA
- Abstract
Postoperative nausea and vomiting (PONV) are frequently occurring adverse effects following surgical procedures. Despite predictive risk scores and a pallet of prophylactic antiemetic treatments, it is still estimated to affect around 30% of the patients, reducing their well-being and increasing the burden of post-operative care. The aim of the current study was to characterize selected genetic risk factors of PONV to improve the identification of at risk patients. We genotyped 601 patients followed during the first 24 h after surgery for PONV symptoms in the absence of any antiemetic prophylaxis. These patients were recruited in the frame of a randomized, placebo controlled clinical study aiming to test the efficacy of dexamethasone as a treatment of established PONV. We examined the impact of selected single nucleotide polymorphisms (SNPs) located around 13 different genes and the predicted activity of 6 liver drug metabolizing enzymes from the cytochromes P450 family (CYP) on the occurrence and recurrence of PONV. Our genetic study confirms the importance of genetic variations in the type 3B serotonin receptor in the occurrence of PONV. Our modelling shows that integration of rs3782025 genotype in preoperative risk assessments may help improve the targeting of antiemetic prophylaxis towards patients at risk of PONV., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Gloor, Czarnetzki, Curtin, Gil-Wey, Tramèr and Desmeules.)
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- 2022
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40. Impact of SARS-CoV-2 Infection (COVID-19) on Cytochromes P450 Activity Assessed by the Geneva Cocktail.
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Lenoir C, Terrier J, Gloor Y, Curtin F, Rollason V, Desmeules JA, Daali Y, Reny JL, and Samer CF
- Subjects
- Aged, Aged, 80 and over, C-Reactive Protein metabolism, COVID-19 blood, Cytochrome P-450 Enzyme System genetics, Female, Genetic Variation, Humans, Interleukin-6 blood, Linear Models, Male, Middle Aged, Models, Theoretical, Prospective Studies, Tumor Necrosis Factor-alpha blood, COVID-19 enzymology, Cytochrome P-450 Enzyme System metabolism
- Abstract
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is a severe acute respiratory syndrome with an underlying inflammatory state. We have previously demonstrated that acute inflammation modulates cytochromes P450 (CYPs) activity in an isoform-specific manner. We therefore hypothesized that COVID-19 might also impact CYP activity, and thus aimed to evaluate the impact of acute inflammation in the context of SARS-CoV-2 infection on the six main human CYPs activity. This prospective observational study was conducted in 28 patients hospitalized at the Geneva University Hospitals (Switzerland) with a diagnosis of moderate to severe COVID-19. They received the Geneva phenotyping cocktail orally during the first 72 hours of hospitalization and after 3 months. Capillary blood samples were collected 2 hours after cocktail administration to assess the metabolic ratios (MRs) of CYP1A2, 2B6, 2C9, 2C19, 2D6, and 3A. C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α) levels were also measured in blood. CYP1A2, CYP2C19, and CYP3A MRs decreased by 52.6% (P = 0.0001), 74.7% (P = 0.0006), and 22.8% (P = 0.045), respectively, in patients with COVID-19. CYP2B6 and CYP2C9 MRs increased by 101.1% (P = 0.009) and 55.8% (P = 0.0006), respectively. CYP2D6 MR variation did not reach statistical significance (P = 0.072). As expected, COVID-19 was a good acute inflammation model as mean serum levels of CRP, IL-6, and TNF-α were significantly (P < 0.001) higher during SARS-CoV-2 infection. CYP activity are modulated in an isoform-specific manner by SARS-CoV-2 infection. The pharmacokinetics of CYP substrates, whether used to treat the disease or as the usual treatment of patients, could be therefore clinically impacted., (© 2021 The Authors. Clinical Pharmacology & Therapeutics published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.)
- Published
- 2021
- Full Text
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41. Impact of Acute Inflammation on Cytochromes P450 Activity Assessed by the Geneva Cocktail.
- Author
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Lenoir C, Daali Y, Rollason V, Curtin F, Gloor Y, Bosilkovska M, Walder B, Gabay C, Nissen MJ, Desmeules JA, Hannouche D, and Samer CF
- Subjects
- Aged, Aged, 80 and over, C-Reactive Protein analysis, Drug Combinations, Female, Hip surgery, Humans, Inflammation Mediators blood, Interleukin-6 blood, Isoenzymes genetics, Isoenzymes metabolism, Male, Middle Aged, Models, Biological, Orthopedic Procedures, Phenotype, Postoperative Complications enzymology, Prospective Studies, Tumor Necrosis Factor-alpha blood, Cytochrome P-450 Enzyme System metabolism, Inflammation enzymology
- Abstract
Cytochromes P450 (CYP) are subject to important interindividual variability in their activity due to genetic and environmental factors and some diseases. Limited human data support the idea that inflammation downregulates CYP activities. Our study aimed to evaluate the impact of orthopedic surgery (acute inflammation model) on the activity of six human CYP. This prospective observational study was conducted in 30 patients who underwent elective hip surgery at the Geneva University Hospitals in Switzerland. The Geneva phenotyping cocktail containing caffeine, bupropion, flurbiprofen, omeprazole, dextromethorphan, and midazolam as probe drugs respectively assessing CYP1A2, 2B6, 2C9, 2C19, 2D6, and 3A activities was administered orally before surgery, day 1 (D1) and 3 (D3) postsurgery and at discharge. Capillary blood samples were collected 2 hours after cocktail intake to assess metabolic ratios (MRs). Serum inflammatory markers (CRP, IL-6, IL-1β, TNF-α, and IFN-γ) were also measured in blood. CYP1A2 MRs decreased by 53% (P < 0.0001) between baseline and the nadir at D1. CYP2C19 and CYP3A activities (MRs) decreased by 57% (P = 0.0002) and 61% (P < 0.0001), respectively, with the nadir at D3. CYP2B6 and CYP2C9 MRs increased by 120% (P < 0.0001) and 79% (P = 0.018), respectively, and peaked at D1. Surgery did not have a significant impact on CYP2D6 MR. Hip surgery was a good acute inflammation model as CRP, IL-6, and TNF-α peak levels were reached between D1 and day 2 (D2). Acute inflammation modulated CYP activity in an isoform-specific manner, with different magnitudes and kinetics. Acute inflammation may thus have a clinically relevant impact on the pharmacokinetics of these CYP substrates., (© 2020 The Authors. Clinical Pharmacology & Therapeutics published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.)
- Published
- 2021
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42. Impacts of Touch massage on the experience of patients with chronic pain: A protocol for a mixed method study.
- Author
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Da Rocha Rodrigues MG, Bollondi Pauly C, Thentz C, Boegli M, Curtin F, Luthy C, Cedraschi C, and Desmeules J
- Subjects
- Humans, Quality of Life, Chronic Pain therapy, Massage, Touch
- Abstract
Background: Chronic pain is a major public health problem. It affects the quality of life of many patients and their families and compromises physical and social functioning and psychological well-being. Non-pharmacological interventions are increasingly being used as a complement to chronic pain care. One of these interventions is Touch massage (TM) that can provide relaxation, comfort and well-being. In addition to its various physiological functions, TM can be used as a social communication tool., Materials and Methods: This is a cluster study with an exploratory qualitative part. Two groups will be considered: the experimental group will benefit from a TM delivered by trained members of care team and the control group will benefit from an intervention of the same duration with a foot massage device. At least 4 sessions will be delivered and spread over two weeks. Sample size calculation showed that 78 participants (39 per group) need to be included. As for the qualitative part, semi-structured interviews will be conducted to investigate the patients' perception of the intervention; focus groups will explore the satisfaction and general perception of the health care teams., Expected Results: Incorporating TM interventions into care planning could bring benefits in supporting patients suffering from chronic pain. TM is expected to increase the patients' feelings that their pain is seriously considered; physical and psychological support should help improve their sense of comfort and well-being and hence their quality of life. This practice might thus improve the caregiver-patient relationship with TM as a providing a new means of establishing communication through touch., Trial Registration: ClinicalTrials.gov, NCT04295603, Registered on March 4, 2020., (Copyright © 2020 Elsevier Ltd. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
43. Temelimab, an IgG4 Anti-Human Endogenous Retrovirus Monoclonal Antibody: An Early Development Safety Review.
- Author
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Kornmann G and Curtin F
- Subjects
- Antibodies, Monoclonal adverse effects, Antibodies, Monoclonal, Humanized adverse effects, Clinical Trials, Phase I as Topic, Clinical Trials, Phase II as Topic, Drug-Related Side Effects and Adverse Reactions etiology, Gene Products, env immunology, Humans, Immunoglobulin G immunology, Antibodies, Monoclonal therapeutic use, Antibodies, Monoclonal, Humanized therapeutic use, Multiple Sclerosis drug therapy
- Abstract
Introduction: Temelimab (formerly called GNbAC1) is an immunoglobulin (Ig) G4 monoclonal antibody that targets the human endogenous retroviral envelope protein HERV-W-Env, shown to be associated with the pathogenesis of certain autoimmune disorders such as multiple sclerosis (MS) and type 1 diabetes mellitus (T1D). By neutralizing HERV-W-Env, temelimab could act as a disease-modifying therapy for these disorders. It is currently in clinical development for MS and T1D., Methods: The safety information on temelimab (including potential infusion-related reactions, malignancies, pregnancies and antidrug antibodies) collected during three phase I and four phase II clinical trials was reviewed and is summarized in this article., Results: In the entire development program, 54 healthy volunteers received single doses of temelimab in three phase I studies, and 334 MS or T1D patients received temelimab for a total estimated exposure of 465 patient-years in four phase II trials. No differences were observed between numbers of treatment-emergent adverse events (TEAEs) or serious adverse events (SAEs) between treatment groups (including placebo), and the number of SAEs was limited. Furthermore, no differences were observed in laboratory evaluations, vital signs, electrocardiogram (ECG), or physical examinations between treatment groups. Rare potential infusion-related reactions were reported. Temelimab treatment was not associated with an increased risk of infections or infestations., Conclusion: These results suggest that treatment with temelimab was not associated with any particular type of AE. Overall, temelimab was safe and very well tolerated over the tested dose range after repeated monthly administrations.
- Published
- 2020
- Full Text
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44. GABAergic modulation of secondary hyperalgesia: A randomized controlled 4-way crossover trial with the α2-subunit preferring GABA positive allosteric modulator, N-desmethyl-clobazam in healthy volunteers.
- Author
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Matthey A, Daali Y, Curtin F, Poncet A, Desmeules J, and Besson M
- Subjects
- Cross-Over Studies, Double-Blind Method, Healthy Volunteers, Humans, gamma-Aminobutyric Acid, Benzodiazepines therapeutic use, Clobazam therapeutic use, Hyperalgesia chemically induced, Hyperalgesia drug therapy
- Abstract
The antihyperalgesic and sedative effects of the α2-subunit preferring GABA
A positive allosteric modulator (GAM), N-desmethyl-clobazam (NDMC), 20 and 60 mg, were assessed in a randomized, placebo and active-controlled (clonazepam 1,5 mg), 4-way crossover study, in healthy volunteers, using the ultraviolet B-induced experimental pain model. Single (20, 40, 60 mg) and repeated doses (20 mg over 15 days) of NDMC pharmacokinetics were evaluated. Thirty-two subjects participated in the study. Primary outcome parameter was maximal change in the area of cutaneous UVB irradiation-induced secondary hyperalgesia (ASH). ASH decreased under all treatments. Mean (SD) relative change was 79 (22)%, 83 (24)%, 77 (30)% and 92 (16)% for placebo, NDMC20, NDMC60 and clonazepam, respectively. Neither absolute change nor relative change in ASH was significantly different between NDMC60 and placebo (mean difference = 2.3 cm2 [95% CI 4.0-8.5], p = .462 and 0.4% [-11.9 to 12.6], p = .952, respectively). An overall treatment effect was found on level of sedation. Compared to placebo, sedation was higher under clonazepam (mean difference = 39 mm [30-49] on a visual analogue scale, p < .001) while NDMC was free of sedative effect. NDMC pharmacokinetics after single doses showed poor absorption, but was linear. Steady-state plasma concentrations of NDMC20 were attained within 14 days, with low between-subjects variability. Mean steady-state concentration (CS-S , SD) reached 209 (22) ng/ml. NDMC absence of sedative effect and its overall well-characterized safety coming from years of utilization as a metabolite from clobazam, raise the prospect of dose escalating trials in patients to quantify its clinical utility. SIGNIFICANCE: This article, presenting the Phase I data of the new antihyperalgesic compound, α2-subunit GABAA positive allosteric modulator, N-desmethyl-clobazam (NDMC) is exploring the modulation of a new target in the treatment of neuropathic pain. Based on these results and on its preclinical properties NDMC would qualify as a good tool compound to seek confirmation of the clinical utility of selective GABA allosteric modulators in neuropathic pain patients., (© 2020 European Pain Federation - EFIC®.)- Published
- 2020
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45. A safety and pharmacodynamics study of temelimab, an antipathogenic human endogenous retrovirus type W envelope monoclonal antibody, in patients with type 1 diabetes.
- Author
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Curtin F, Champion B, Davoren P, Duke S, Ekinci EI, Gilfillan C, Morbey C, Nathow T, O'Moore-Sullivan T, O'Neal D, Roberts A, Stranks S, Stuckey B, Vora P, Malpass S, Lloyd D, Maëstracci-Beard N, Buffet B, Kornmann G, Bernard C, Porchet H, and Simpson R
- Subjects
- Adult, Antibodies, Monoclonal adverse effects, Antibodies, Monoclonal, Humanized, Double-Blind Method, Humans, Hypoglycemic Agents, Diabetes Mellitus, Type 1 drug therapy, Endogenous Retroviruses
- Abstract
Aim: To report the first study of temelimab, a monoclonal antibody neutralizing the pathogenic human endogenous retrovirus type W envelope, in patients with type 1 diabetes (T1D)., Materials and Methods: This double-blind, placebo-controlled, randomized clinical trial recruited adult patients with T1D within 4 years postdiagnosis and remaining C-peptide secretion. Sixty-four patients were randomized (2:1) to monthly temelimab 6 mg/kg or placebo during 24 weeks followed by a 24-week, open-label extension, during which all patients received temelimab. The primary objective was the safety and tolerability of temelimab. The secondary objective was to assess the pharmacodynamics response such as C-peptide levels, insulin use, HbA1c, hypoglycaemia and autoantibodies., Results: Temelimab was well tolerated without any group difference in the frequency or severity of adverse events. Concerning exploratory endpoints, there was no difference in the levels of C-peptide, insulin use or HbA1c between treatment groups at weeks 24 and 48. The frequency of hypoglycaemia events was reduced with temelimab (P = 0.0004) at week 24 and the level of anti-insulin antibodies was lower with temelimab (P < 0.01); the other autoantibodies did not differ between groups., Conclusions: Temelimab appeared safe in patients with T1D. Pharmacodynamics signals (hypoglycaemia and anti-insulin antibodies) under temelimab were observed. Markers of β-cell functions were not modified by treatment. These results need to be further explored in younger patients with T1D with earlier disease onset., (© 2020 John Wiley & Sons Ltd.)
- Published
- 2020
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46. A High-dose Pharmacokinetic Study of a New IgG4 Monoclonal Antibody Temelimab/GNbAC1 Antagonist of an Endogenous Retroviral Protein pHERV-W Env.
- Author
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Porchet H, Vidal V, Kornmann G, Malpass S, and Curtin F
- Subjects
- Adult, Antibodies, Monoclonal, Humanized adverse effects, Double-Blind Method, Endogenous Retroviruses, Healthy Volunteers, Humans, Infusions, Intravenous, Male, Multiple Sclerosis drug therapy, Young Adult, Antibodies, Monoclonal, Humanized pharmacokinetics, Gene Products, env antagonists & inhibitors, Immunoglobulin G, Pregnancy Proteins antagonists & inhibitors
- Abstract
Purpose: Temelimab/GNbAC1 is a humanized immunoglobulin G4 monoclonal antibody antagonist of the human endogenous retrovirus W envelope protein, which is associated with multiple sclerosis (MS) pathophysiology and possibly with other autoimmune disorders. Human endogenous retrovirus W envelope protein is expressed in the central nervous system of patients with MS, and sufficient amount of temelimab must reach the target. The safety of very high dosages of temelimab should be tested to support further clinical trials in MS., Methods: This randomized, placebo-controlled, dose-escalation study evaluated the safety and pharmacokinetic profile of temelimab in 24 healthy volunteers after a single intravenous infusion at doses of 36, 60, 85, and 110 mg/kg administered sequentially., Findings: Temelimab was well tolerated, with no particular adverse drug reactions at any dose. The maximal dose of 110 mg/kg could be administered, and no antidrug antibodies were induced. After administration of 36-110 mg/kg, mean temelimab C
max increased from 859 to 2450 μg/mL, and AUC values increased from 319,900 to 1,030,000 μg·h/mL. There was an approximate dose-proportional increase in exposure, similar to observations at lower doses., Implications: The favorable data in terms of safety and pharmacokinetic variables support temelimab use at high doses in future MS trials to optimally neutralize the temelimab target in the central nervous system. ClinicalTrials.gov identifier: NCT03574428., (Copyright © 2019. Published by Elsevier Inc.)- Published
- 2019
- Full Text
- View/download PDF
47. Prevention of clinical and histological signs of MOG-induced experimental allergic encephalomyelitis by prolonged treatment with recombinant human EGF.
- Author
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Nicoletti F, Mazzon E, Fagone P, Mangano K, Mammana S, Cavalli E, Basile MS, Bramanti P, Scalabrino G, Lange A, and Curtin F
- Subjects
- Animals, Brain pathology, CD4-Positive T-Lymphocytes immunology, CD4-Positive T-Lymphocytes metabolism, Dexamethasone therapeutic use, Encephalomyelitis, Autoimmune, Experimental chemically induced, Encephalomyelitis, Autoimmune, Experimental pathology, Encephalomyelitis, Autoimmune, Experimental prevention & control, Epidermal Growth Factor administration & dosage, Epidermal Growth Factor biosynthesis, Epidermal Growth Factor genetics, ErbB Receptors analysis, ErbB Receptors biosynthesis, ErbB Receptors genetics, Female, Humans, Mice, Inbred C57BL, Myelin-Oligodendrocyte Glycoprotein toxicity, Peptide Fragments toxicity, Recombinant Proteins administration & dosage, Recombinant Proteins therapeutic use, Spinal Cord chemistry, Spinal Cord pathology, Transcriptome, Encephalomyelitis, Autoimmune, Experimental drug therapy, Epidermal Growth Factor therapeutic use
- Abstract
Epidermal growth factor (EGF) represents the prototype of the group I EGF family. The pleiotropic effects of the EGF have attracted attention to the possibility that it could be implicated in autoimmune diseases, such as Multiple Sclerosis (MS). We show here that treatment with EGF, as a late prophylactic regime, improved the clinical and histological features of EAE, a preclinical model of MS. In silico analysis further corroborated these findings by demonstrating that EGF receptors are less expressed in CNS from patients with MS as compared to controls. Taken together these data provide clear-cut in vivo proof of concept for a beneficial role of exogenously administered EGF in MS, that may, therefore, represent a novel therapeutic approach., (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Published
- 2019
- Full Text
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48. A new therapeutic approach for type 1 diabetes: Rationale for GNbAC1, an anti-HERV-W-Env monoclonal antibody.
- Author
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Curtin F, Bernard C, Levet S, Perron H, Porchet H, Médina J, Malpass S, Lloyd D, and Simpson R
- Subjects
- Diabetes Mellitus, Type 1 virology, Endogenous Retroviruses immunology, Gene Products, env blood, Gene Products, env immunology, Humans, Antibodies, Monoclonal, Humanized pharmacology, Diabetes Mellitus, Type 1 drug therapy, Endogenous Retroviruses drug effects, Gene Products, env drug effects, Immunologic Factors pharmacology
- Abstract
We describe a newly identified therapeutic target for type 1 diabetes (T1D): an envelope protein of endogenous retroviral origin, human endogenous retrovirus W envelope (HERV-W-Env). HERV-W-Env was found to be detected in the blood of ~60% of patients with T1D and is expressed in acinar pancreatic cells of 75% of patients with T1D at post mortem examination. Preclinical experiments showed that this protein displays direct cytotoxicity on human β-islet cells. In vivo HERV-W-Env impairs the insulin and glucose metabolism in transgenic mice expressing HERV-W-Env. GNbAC1, an IgG4 monoclonal antibody, has been developed to specifically target HERV-W-Env and to neutralize the effect of HERV-W-Env in vitro and in vivo. GNbAC1 is currently in clinical development for multiple sclerosis and > 300 subjects have been administered with GNbAC1 so far. GNbAC1 is now being tested in T1D in the RAINBOW-T1D study, which is a randomized placebo-controlled study with the objective of showing the safety and pharmacodynamic response of GNbAC1 in patients who have had T1D with a maximum of 4 years' duration. GNbAC1 is being tested vs placebo at the dose of 6 mg/kg in 60 patients during six repeated administrations for 6 months; a 6-month open-label extension will follow. The primary endpoint is to assess safety, and secondary endpoints are the pharmacodynamic responses to GNbAC1. GNbAC1 targeting HERV-W-Env is currently in clinical development in T1D, with the first safety and pharmacodynamic study. If the study results are positive, this may open the door to the development of an innovative non-immunomodulatory disease-modifying treatment for T1D., (© 2018 John Wiley & Sons Ltd.)
- Published
- 2018
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49. Corrections to effect size variances for continuous outcomes of crossover clinical trials.
- Author
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Kitchenham B, Madeyski L, and Curtin F
- Subjects
- Cross-Over Studies, Models, Statistical
- Published
- 2018
- Full Text
- View/download PDF
50. Meta-analysis combining parallel and crossover trials using generalised estimating equation method.
- Author
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Curtin F
- Subjects
- Bias, Clinical Trials as Topic, Cross-Over Studies, Humans, Research Design, Statistics as Topic, Meta-Analysis as Topic
- Abstract
Clinical trials have different designs: In late stage drug development, the parallel trial design is the most frequent one; however, the crossover design is not rare; different techniques are used to analyse their results. Although both designs measure the same treatment effect, combining parallel and crossover trials in a meta-analysis is not straightforward. We present here a meta-analysis method based on generalised estimating equation (GEE) regression to combine aggregated results of crossover and parallel trials using a marginal estimation approach. This method is based on the fixed effects meta-analytic model; it allows combining average outcomes belonging to the exponential distributions obtained from trials of different designs and in particular from crossover trials with more than 2 periods and 2 treatments. By extending the methods proposed so far to combine the 2 trial designs, the GEE regression allows for adjusting for bias, such as a carry-over effect typical in crossover trials. In this paper, the GEE meta-analysis method is compared to the classical weighted average method with examples of published and simulated meta-analyses. Although the GEE can account for crossover specificities, it is limited by the availability of detailed trial information often encountered with reports of these trials., (Copyright © 2017 John Wiley & Sons, Ltd.)
- Published
- 2017
- Full Text
- View/download PDF
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