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4. Table of Contents

Author

Curry, Timothy Jon, Schwirian, Kent, and Woldoff, Rachael A.

Published
2004

5. Acknowledgments

Author

Curry, Timothy Jon, Schwirian, Kent, and Woldoff, Rachael A.

Published
2004

7. List of Illustrations

Author

Curry, Timothy Jon, Schwirian, Kent, and Woldoff, Rachael A.

Published
2004

8. Preface

Author

Curry, Timothy Jon, Schwirian, Kent, and Woldoff, Rachael A.

Published
2004

9. 2. The Stadium Game

Author

Curry, Timothy Jon, Schwirian, Kent, and Woldoff, Rachael A.

Published
2004

12. Cover

Author

Curry, Timothy Jon, Schwirian, Kent, and Woldoff, Rachael A.

Published
2004

14. Index

Author

Curry, Timothy Jon, Schwirian, Kent, and Woldoff, Rachael A.

Published
2004

18. Notes

Author

Curry, Timothy Jon, Schwirian, Kent, and Woldoff, Rachael A.

Published
2004

19. Non-invasive biomarkers for detecting progression toward hypovolemic cardiovascular instability in a lower body negative pressure model

Author

Murphy, Ethan K., Bertsch, Spencer R., Klein, Samuel B., Rashedi, Navid, Sun, Yifei, Joyner, Michael J., Curry, Timothy B., Johnson, Christopher P., Regimbal, Riley J., Wiggins, Chad C., Senefeld, Jonathon W., Shepherd, John R. A., Elliott, Jonathan Thomas, Halter, Ryan J., Vaze, Vikrant S., and Paradis, Norman A.

Published
2024
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23. FASHION: Functional and Attack graph Secured HybrId Optimization of virtualized Networks

Author

Callahan, Devon, Curry, Timothy, Davidson, Hazel, Zitoun, Heytem, Fuller, Benjamin, and Michel, Laurent

Subjects
Computer Science - Networking and Internet Architecture, Computer Science - Cryptography and Security, C.2.1, C.2.3, G.1.6
Abstract

Maintaining a resilient computer network is a delicate task with conflicting priorities. Flows should be served while controlling risk due to attackers. Upon publication of a vulnerability, administrators scramble to manually mitigate risk while waiting for a patch. We introduce FASHION: a linear optimizer that balances routing flows with the security risk posed by these flows. FASHION formalizes routing as a multi-commodity flow problem with side constraints. FASHION formulates security using two approximations of risk in a probabilistic attack graph (Frigault et al., Network Security Metrics 2017). FASHION's output is a set of software-defined networking rules consumable by Frenetic (Foster et al., ICFP 2011). We introduce a topology generation tool that creates data center network instances including flows and vulnerabilities. FASHION is executed on instances of up to 600 devices, thousands of flows, and million edge attack graphs. Solve time averages 30 minutes on the largest instances (seconds on the smallest instances). To ensure the security objective is accurate, the output solution is assessed using risk as defined by Frigault et al. FASHION allows enterprises to reconfigure their network in response to changes in functionality or security requirements., Comment: Accepted to IEEE TDSC. This version adds an online evaluation Sections 4.2 and 5.2.4

Published
2019

24. DOCSDN: Dynamic and Optimal Configuration of Software-Defined Networks

Author

Curry, Timothy, Callahan, Devon, Fuller, Benjamin, and Michel, Laurent

Subjects
Computer Science - Cryptography and Security, Computer Science - Networking and Internet Architecture
Abstract

Networks are designed with functionality, security, performance, and cost in mind. Tools exist to check or optimize individual properties of a network. These properties may conflict, so it is not always possible to run these tools in series to find a configuration that meets all requirements. This leads to network administrators manually searching for a configuration. This need not be the case. In this paper, we introduce a layered framework for optimizing network configuration for functional and security requirements. Our framework is able to output configurations that meet reachability, bandwidth, and risk requirements. Each layer of our framework optimizes over a single property. A lower layer can constrain the search problem of a higher layer allowing the framework to converge on a joint solution. Our approach has the most promise for software-defined networks which can easily reconfigure their logical configuration. Our approach is validated with experiments over the fat tree topology, which is commonly used in data center networks. Search terminates in between 1-5 minutes in experiments. Thus, our solution can propose new configurations for short term events such as defending against a focused network attack.

Published
2019

25. What is new in perioperative dysglycemia?

Author

Long, Micah T., Anderson, Alexandra L., and Curry, Timothy B.

Subjects
Dextrose, Glucose, Blood sugar monitoring, Type 2 diabetes, Hyperglycemia, Health care industry
Abstract

Author(s): Micah T. Long [sup.1], Alexandra L. Anderson [sup.2], Timothy B. Curry [sup.2] Author Affiliations: (1) grid.412647.2, 0000 0000 9209 0955, Department of Anesthesiology, University of Wisconsin Hospitals and Clinics, [...]

Published
2022
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27. Implementation of preemptive DNA sequence–based pharmacogenomics testing across a large academic medical center: The Mayo-Baylor RIGHT 10K Study

Author

Wang, Liewei, Scherer, Steven E., Bielinski, Suzette J., Muzny, Donna M., Jones, Leila A., Black, John Logan, III, Moyer, Ann M., Giri, Jyothsna, Sharp, Richard R., Matey, Eric T., Wright, Jessica A., Oyen, Lance J., Nicholson, Wayne T., Wiepert, Mathieu, Sullard, Terri, Curry, Timothy B., Rohrer Vitek, Carolyn R., McAllister, Tammy M., St. Sauver, Jennifer L., Caraballo, Pedro J., Lazaridis, Konstantinos N., Venner, Eric, Qin, Xiang, Hu, Jianhong, Kovar, Christie L., Korchina, Viktoriya, Walker, Kimberly, Doddapaneni, HarshaVardhan, Wu, Tsung-Jung, Raj, Ritika, Denson, Shawn, Liu, Wen, Chandanavelli, Gauthami, Zhang, Lan, Wang, Qiaoyan, Kalra, Divya, Karow, Mary Beth, Harris, Kimberley J., Sicotte, Hugues, Peterson, Sandra E., Barthel, Amy E., Moore, Brenda E., Skierka, Jennifer M., Kluge, Michelle L., Kotzer, Katrina E., Kloke, Karen, Vander Pol, Jessica M., Marker, Heather, Sutton, Joseph A., Kekic, Adrijana, Ebenhoh, Ashley, Bierle, Dennis M., Schuh, Michael J., Grilli, Christopher, Erickson, Sara, Umbreit, Audrey, Ward, Leah, Crosby, Sheena, Nelson, Eric A., Levey, Sharon, Elliott, Michelle, Peters, Steve G., Pereira, Naveen, Frye, Mark, Shamoun, Fadi, Goetz, Matthew P., Kullo, Iftikhar J., Wermers, Robert, Anderson, Jan A., Formea, Christine M., El Melik, Razan M., Zeuli, John D., Herges, Joseph R., Krieger, Carrie A., Hoel, Robert W., Taraba, Jodi L., St. Thomas, Scott R., Absah, Imad, Bernard, Matthew E., Fink, Stephanie R., Gossard, Andrea, Grubbs, Pamela L., Jacobson, Therese M., Takahashi, Paul, Zehe, Sharon C., Buckles, Susan, Bumgardner, Michelle, Gallagher, Colette, Fee-Schroeder, Kelliann, Nicholas, Nichole R., Powers, Melody L., Ragab, Ahmed K., Richardson, Darcy M., Stai, Anthony, Wilson, Jaymi, Pacyna, Joel E., Olson, Janet E., Sutton, Erica J., Beck, Annika T., Horrow, Caroline, Kalari, Krishna R., Larson, Nicholas B., Liu, Hongfang, Wang, Liwei, Lopes, Guilherme S., Borah, Bijan J., Freimuth, Robert R., Zhu, Ye, Jacobson, Debra J., Hathcock, Matthew A., Armasu, Sebastian M., McGree, Michaela E., Jiang, Ruoxiang, Koep, Tyler H., Ross, Jason L., Hilden, Matthew G., Bosse, Kathleen, Ramey, Bronwyn, Searcy, Isabelle, Boerwinkle, Eric, Gibbs, Richard A., and Weinshilboum, Richard M.

Published
2022
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31. Central α2‐adrenergic mechanisms regulate human sympathetic neuronal discharge strategies.

Author

Klassen, Stephen A., Limberg, Jacqueline K., Harvey, Ronée E., Wiggins, Chad C., Iannarelli, Nathaniel J., Senefeld, Jonathon W., Nicholson, Wayne T., Curry, Timothy B., Joyner, Michael J., Shoemaker, J. Kevin, and Baker, Sarah E.

Subjects
ADRENERGIC mechanisms, SYMPATHETIC nervous system, SPLANCHNIC nerves, DEXMEDETOMIDINE, HEART beat
Abstract

The present study investigated the impact of central α2‐adrenergic mechanisms on sympathetic action potential (AP) discharge, recruitment and latency strategies. We used the microneurographic technique to record muscle sympathetic nerve activity and a continuous wavelet transform to investigate postganglionic sympathetic AP firing during a baseline condition and an infusion of a α2‐adrenergic receptor agonist, dexmedetomidine (10 min loading infusion of 0.225 µg kg−1; maintenance infusion of 0.1–0.5 µg kg h−1) in eight healthy individuals (28 ± 7 years, five females). Dexmedetomidine reduced mean pressure (92 ± 7 to 80 ± 8 mmHg, P < 0.001) but did not alter heart rate (61 ± 13 to 60 ± 14 bpm; P = 0.748). Dexmedetomidine reduced sympathetic AP discharge (126 ± 73 to 27 ± 24 AP 100 beats−1, P = 0.003) most strongly for medium‐sized APs (normalized cluster 2: 21 ± 10 to 5 ± 5 AP 100 beats−1; P < 0.001). Dexmedetomidine progressively de‐recruited sympathetic APs beginning with the largest AP clusters (12 ± 3 to 7 ± 2 clusters, P = 0.002). Despite de‐recruiting large AP clusters with shorter latencies, dexmedetomidine reduced AP latency across remaining clusters (1.18 ± 0.12 to 1.13 ± 0.13 s, P = 0.002). A subset of six participants performed a Valsalva manoeuvre (20 s, 40 mmHg) during baseline and the dexmedetomidine infusion. Compared to baseline, AP discharge (Δ 361 ± 292 to Δ 113 ± 155 AP 100 beats−1, P = 0.011) and AP cluster recruitment elicited by the Valsalva manoeuvre were lower during dexmedetomidine (Δ 2 ± 1 to Δ 0 ± 2 AP clusters, P = 0.041). The reduction in sympathetic AP latency elicited by the Valsalva manoeuvre was not affected by dexmedetomidine (Δ –0.09 ± 0.07 to Δ –0.07 ± 0.14 s, P = 0.606). Dexmedetomidine reduced baroreflex gain, most strongly for medium‐sized APs (normalized cluster 2: –6.0 ± 5 to –1.6 ± 2 % mmHg−1; P = 0.008). These data suggest that α2‐adrenergic mechanisms within the central nervous system modulate sympathetic postganglionic neuronal discharge, recruitment and latency strategies in humans. Key points: Sympathetic postganglionic neuronal subpopulations innervating the human circulation exhibit complex patterns of discharge, recruitment and latency. However, the central neural mechanisms governing sympathetic postganglionic discharge remain unclear.This microneurographic study investigated the impact of a dexmedetomidine infusion (α2‐adrenergic receptor agonist) on muscle sympathetic postganglionic action potential (AP) discharge, recruitment and latency patterns.Dexmedetomidine infusion inhibited the recruitment of large and fast conducting sympathetic APs and attenuated the discharge of medium sized sympathetic APs that fired during resting conditions and the Valsalva manoeuvre.Dexmedetomidine infusion elicited shorter sympathetic AP latencies during resting conditions but did not affect the reductions in latency that occurred during the Valsalva manoeuvre.These data suggest that α2‐adrenergic mechanisms within the central nervous system modulate sympathetic postganglionic neuronal discharge, recruitment and latency strategies in humans. [ABSTRACT FROM AUTHOR]

Published
2024
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33. JONES DAY TALKS[R]: Corporate Venture Capital Investing (Podcast)

Author

Curry, Timothy

Subjects
Corporations -- Investments -- Forecasts and trends, Venture capital -- Forecasts and trends, Market trend/market analysis, Venture capital, Company investment, Business, international
Abstract

Podcast: Play in new window | Download SUBSCRIBE TO JONES DAY TALKS® Subscribe on Apple Podcasts Subscribe on Android Subscribe on Google Play Subscribe on Stitcher LISTEN TO PREVIOUS PODCASTS [...]

Published
2024

39. Satellite-Linked Remote Physiologic Monitoring During Simulated Rural Ground Ambulance and Rotor Wing Transports

Author

Russi, Christopher S., primary, Felton, Christopher, additional, Liedl, Chad, additional, Carey, William A., additional, Curry, Timothy B., additional, Flipse, Thomas R., additional, Gleich, Stephen J., additional, Holmes, David R., additional, Noel, Pierre, additional, Luke, Anu, additional, Klassen, Aaron, additional, and Haider, Clifton R., additional

Published
2023
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