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This article reviews the motion picture Daddy & Papa. Daddy & Papa is a film that adds needed depth in gay male fathering. It is engaging and interesting, drawing viewers into the parenting experiences of four gay families. The film, directed and produced by Symons, is an important addition for presenting the experiences of gay male parents to college and university students. In addition to discussing gay male parenting, the film also presents experiences with adoption, interracial families, the law and homophobia. The film follows four gay male families and involves viewers in the expectations, experiences, hopes and ideals of the parents, children and of society. The film delineates a number of parenting issues. Some of these issues are unique to gay parenting and some are not. The film also presents a more general theme which is society's lack of understanding about gay parenting. This lack of understanding happens both within general society and within the gay community. Finally, the film examines the issue of interracial adoption. Most of the families in the film are interracial. The film is appropriate for students at all levels. In an introductory sociology course, the film could be integrated integrated into the family chapter and could be used to focus on the issue of what constitutes a family.

This article reviews the motion picture One + One. The film follows the daily struggles of two couples, one heterosexual and the other homosexual. One partner from each couple is HIV positive. Both couples entered their relationships knowing the HIV status of the other person. The film follows the couples through their daily routines while presenting their concerns about the HIV status of their partners. Although the film touches on many issues, they are not covered in any detail. Issues include sexual relationships, insurance issues, family reactions, failing health, children, medication, and guilt. The film is well done and well constructed. It is appropriate for upper level college courses and graduate courses. Its themes fit nicely in marriage and family, relationships and sexuality courses. In addition to HIV and AIDS concepts, the film also includes scenes about sexual identity, companionate and passionate love, social networks, monogamous relationships, courtship, and concerns about aging. Instructors using this film should be prepared to present information on HIV and AIDS, as the film deals more with the experiences and emotions of two couples, and less with the technical aspects of the disease.

A high density of tumor-associated macrophages (TAMs) is associated with poorer prognosis and survival in breast cancer patients. Recent studies have shown that lipid accumulation in TAMs can promote tumor growth and metastasis in various models. However, the specific molecular mechanisms that drive lipid accumulation and tumor progression in TAMs remain largely unknown. Herein, we demonstrated that unsaturated fatty acids (FAs), unlike saturated ones, are more likely to form lipid droplets in macrophages. Specifically, unsaturated FAs, including linoleic acids (LA), activate the FABP4/CEBPα pathway, leading to triglyceride synthesis and lipid droplet formation. Furthermore, FABP4 enhances lipolysis and FA utilization by breast cancer cells, which promotes cancer cell migration in vitro and metastasis in vivo . Notably, a deficiency of FABP4 in macrophages significantly reduces LA-induced lipid metabolism. Therefore, our findings suggest FABP4 as a crucial lipid messenger that facilitates unsaturated FA-mediated lipid accumulation and lipolysis in TAMs, thus contributing to the metastasis of breast cancer., Highlights: Unlike saturated fatty acids, unsaturated fatty acids preferentially promote lipid droplet formation in macrophages.Unsaturated fatty acids activate the FABP4/CEBPα axis for neutral lipid biosynthesis in macrophagesDeficiency of FABP4 compromised unsaturated fatty acid-mediated lipid accumulation and utilization in macrophagesFABP4-mediated lipid metabolism in macrophages contributes to breast cancer metastasis.