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1. A guide to developing population files for physiologically‐based pharmacokinetic modeling in the Simcyp Simulator.

Author

Curry, Liam, Alrubia, Sarah, Bois, Frederic Y., Clayton, Ruth, El‐Khateeb, Eman, Johnson, Trevor N., Faisal, Muhammad, Neuhoff, Sibylle, Wragg, Kris, and Rostami‐Hodjegan, Amin

Subjects
*CROHN'S disease, *DRUG development, *PHARMACOKINETICS, *KIDNEY diseases, *CONSUMER expertise
Abstract

The Simcyp Simulator is a software platform widely used in the pharmaceutical industry to conduct stochastic physiologically‐based pharmacokinetic (PBPK) modeling. This approach has the advantage of combining routinely generated in vitro data on drugs and drug products with knowledge of biology and physiology parameters to predict a priori potential pharmacokinetic changes in absorption, distribution, metabolism, and excretion for populations of interest. Combining such information with pharmacodynamic knowledge of drugs enables planning for potential dosage adjustment when clinical studies are feasible. Although the conduct of dedicated clinical studies in some patient groups (e.g., with hepatic or renal diseases) is part of the regulatory path for drug development, clinical studies for all permutations of covariates potentially affecting pharmacokinetics are impossible to perform. The role of PBPK in filling the latter gap is becoming more appreciated. This tutorial describes the different input parameters required for the creation of a virtual population giving robust predictions of likely changes in pharmacokinetics. It also highlights the considerations needed to qualify the models for such contexts of use. Two case studies showing the step‐by‐step development and application of population files for obese or morbidly obese patients and individuals with Crohn's disease are provided as the backbone of our tutorial to give some hands‐on and real‐world examples. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Exploring UK medical school differences: the MedDifs study of selection, teaching, student and F1 perceptions, postgraduate outcomes and fitness to practise

Author

McManus, I. C., Harborne, Andrew Christopher, Horsfall, Hugo Layard, Joseph, Tobin, Smith, Daniel T., Marshall-Andon, Tess, Samuels, Ryan, Kearsley, Joshua William, Abbas, Nadine, Baig, Hassan, Beecham, Joseph, Benons, Natasha, Caird, Charlie, Clark, Ryan, Cope, Thomas, Coultas, James, Debenham, Luke, Douglas, Sarah, Eldridge, Jack, Hughes-Gooding, Thomas, Jakubowska, Agnieszka, Jones, Oliver, Lancaster, Eve, MacMillan, Calum, McAllister, Ross, Merzougui, Wassim, Phillips, Ben, Phillips, Simon, Risk, Omar, Sage, Adam, Sooltangos, Aisha, Spencer, Robert, Tajbakhsh, Roxanne, Adesalu, Oluseyi, Aganin, Ivan, Ahmed, Ammar, Aiken, Katherine, Akeredolu, Alimatu-Sadia, Alam, Ibrahim, Ali, Aamna, Anderson, Richard, Ang, Jia Jun, Anis, Fady Sameh, Aojula, Sonam, Arthur, Catherine, Ashby, Alena, Ashraf, Ahmed, Aspinall, Emma, Awad, Mark, Yahaya, Abdul-Muiz Azri, Badhrinarayanan, Shreya, Bandyopadhyay, Soham, Barnes, Sam, Bassey-Duke, Daisy, Boreham, Charlotte, Braine, Rebecca, Brandreth, Joseph, Carrington, Zoe, Cashin, Zoe, Chatterjee, Shaunak, Chawla, Mehar, Chean, Chung Shen, Clements, Chris, Clough, Richard, Coulthurst, Jessica, Curry, Liam, Daniels, Vinnie Christine, Davies, Simon, Davis, Rebecca, De Waal, Hanelie, Desai, Nasreen, Douglas, Hannah, Druce, James, Ejamike, Lady-Namera, Esere, Meron, Eyre, Alex, Fazmin, Ibrahim Talal, Fitzgerald-Smith, Sophia, Ford, Verity, Freeston, Sarah, Garnett, Katherine, General, Whitney, Gilbert, Helen, Gowie, Zein, Grafton-Clarke, Ciaran, Gudka, Keshni, Gumber, Leher, Gupta, Rishi, Harlow, Chris, Harrington, Amy, Heaney, Adele, Ho, Wing Hang Serene, Holloway, Lucy, Hood, Christina, Houghton, Eleanor, Houshangi, Saba, Howard, Emma, Human, Benjamin, Hunter, Harriet, Hussain, Ifrah, Hussain, Sami, Jackson-Taylor, Richard Thomas, Jacob-Ramsdale, Bronwen, Janjuha, Ryan, Jawad, Saleh, Jelani, Muzzamil, Johnston, David, Jones, Mike, Kalidindi, Sadhana, Kalsi, Savraj, Kalyanasundaram, Asanish, Kane, Anna, Kaur, Sahaj, Al-Othman, Othman Khaled, Khan, Qaisar, Khullar, Sajan, Kirkland, Priscilla, Lawrence-Smith, Hannah, Leeson, Charlotte, Lenaerts, Julius Elisabeth Richard, Long, Kerry, Lubbock, Simon, Burrell, Jamie Mac Donald, Maguire, Rachel, Mahendran, Praveen, Majeed, Saad, Malhotra, Prabhjot Singh, Mandagere, Vinay, Mantelakis, Angelos, McGovern, Sophie, Mosuro, Anjola, Moxley, Adam, Mustoe, Sophie, Myers, Sam, Nadeem, Kiran, Nasseri, Reza, Newman, Tom, Nzewi, Richard, Ogborne, Rosalie, Omatseye, Joyce, Paddock, Sophie, Parkin, James, Patel, Mohit, Pawar, Sohini, Pearce, Stuart, Penrice, Samuel, Purdy, Julian, Ramjan, Raisa, Randhawa, Ratan, Rasul, Usman, Raymond-Taggert, Elliot, Razey, Rebecca, Razzaghi, Carmel, Reel, Eimear, Revell, Elliot John, Rigbye, Joanna, Rotimi, Oloruntobi, Said, Abdelrahman, Sanders, Emma, Sangal, Pranoy, Grandal, Nora Sangvik, Shah, Aadam, Shah, Rahul Atul, Shotton, Oliver, Sims, Daniel, Smart, Katie, Smith, Martha Amy, Smith, Nick, Sopian, Aninditya Salma, South, Matthew, Speller, Jessica, Syer, Tom J., Ta, Ngan Hong, Tadross, Daniel, Thompson, Benjamin, Trevett, Jess, Tyler, Matthew, Ullah, Roshan, Utukuri, Mrudula, Vadera, Shree, Van Den Tooren, Harriet, Venturini, Sara, Vijayakumar, Aradhya, Vine, Melanie, Wellbelove, Zoe, Wittner, Liora, Yong, Geoffrey Hong Kiat, Ziyada, Farris, and Devine, Oliver Patrick

Published
2020
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4. The Analysis of Teaching of Medical Schools (AToMS) survey: an analysis of 47,258 timetabled teaching events in 25 UK medical schools relating to timing, duration, teaching formats, teaching content, and problem-based learning

Author

Devine, Oliver Patrick, Harborne, Andrew Christopher, Horsfall, Hugo Layard, Joseph, Tobin, Marshall-Andon, Tess, Samuels, Ryan, Kearsley, Joshua William, Abbas, Nadine, Baig, Hassan, Beecham, Joseph, Benons, Natasha, Caird, Charlie, Clark, Ryan, Cope, Thomas, Coultas, James, Debenham, Luke, Douglas, Sarah, Eldridge, Jack, Hughes-Gooding, Thomas, Jakubowska, Agnieszka, Jones, Oliver, Lancaster, Eve, MacMillan, Calum, McAllister, Ross, Merzougui, Wassim, Phillips, Ben, Phillips, Simon, Risk, Omar, Sage, Adam, Sooltangos, Aisha, Spencer, Robert, Tajbakhsh, Roxanne, Adesalu, Oluseyi, Aganin, Ivan, Ahmed, Ammar, Aiken, Katherine, Akeredolu, Alimatu-Sadia, Alam, Ibrahim, Ali, Aamna, Anderson, Richard, Ang, Jia Jun, Anis, Fady Sameh, Aojula, Sonam, Arthur, Catherine, Ashby, Alena, Ashraf, Ahmed, Aspinall, Emma, Awad, Mark, Yahaya, Abdul-Muiz Azri, Badhrinarayanan, Shreya, Bandyopadhyay, Soham, Barnes, Sam, Bassey-Duke, Daisy, Boreham, Charlotte, Braine, Rebecca, Brandreth, Joseph, Carrington, Zoe, Cashin, Zoe, Chatterjee, Shaunak, Chawla, Mehar, Chean, Chung Shen, Clements, Chris, Clough, Richard, Coulthurst, Jessica, Curry, Liam, Daniels, Vinnie Christine, Davies, Simon, Davis, Rebecca, De Waal, Hanelie, Desai, Nasreen, Douglas, Hannah, Druce, James, Ejamike, Lady-Namera, Esere, Meron, Eyre, Alex, Fazmin, Ibrahim Talal, Fitzgerald-Smith, Sophia, Ford, Verity, Freeston, Sarah, Garnett, Katherine, General, Whitney, Gilbert, Helen, Gowie, Zein, Grafton-Clarke, Ciaran, Gudka, Keshni, Gumber, Leher, Gupta, Rishi, Harlow, Chris, Harrington, Amy, Heaney, Adele, Ho, Wing Hang Serene, Holloway, Lucy, Hood, Christina, Houghton, Eleanor, Houshangi, Saba, Howard, Emma, Human, Benjamin, Hunter, Harriet, Hussain, Ifrah, Hussain, Sami, Jackson-Taylor, Richard Thomas, Jacob-Ramsdale, Bronwen, Janjuha, Ryan, Jawad, Saleh, Jelani, Muzzamil, Johnston, David, Jones, Mike, Kalidindi, Sadhana, Kalsi, Savraj, Kalyanasundaram, Asanish, Kane, Anna, Kaur, Sahaj, Al-Othman, Othman Khaled, Khan, Qaisar, Khullar, Sajan, Kirkland, Priscilla, Lawrence-Smith, Hannah, Leeson, Charlotte, Lenaerts, Julius Elisabeth Richard, Long, Kerry, Lubbock, Simon, Burrell, Jamie Mac Donald, Maguire, Rachel, Mahendran, Praveen, Majeed, Saad, Malhotra, Prabhjot Singh, Mandagere, Vinay, Mantelakis, Angelos, McGovern, Sophie, Mosuro, Anjola, Moxley, Adam, Mustoe, Sophie, Myers, Sam, Nadeem, Kiran, Nasseri, Reza, Newman, Tom, Nzewi, Richard, Ogborne, Rosalie, Omatseye, Joyce, Paddock, Sophie, Parkin, James, Patel, Mohit, Pawar, Sohini, Pearce, Stuart, Penrice, Samuel, Purdy, Julian, Ramjan, Raisa, Randhawa, Ratan, Rasul, Usman, Raymond-Taggert, Elliot, Razey, Rebecca, Razzaghi, Carmel, Reel, Eimear, Revell, Elliot John, Rigbye, Joanna, Rotimi, Oloruntobi, Said, Abdelrahman, Sanders, Emma, Sangal, Pranoy, Grandal, Nora Sangvik, Shah, Aadam, Shah, Rahul Atul, Shotton, Oliver, Sims, Daniel, Smart, Katie, Smith, Martha Amy, Smith, Nick, Sopian, Aninditya Salma, South, Matthew, Speller, Jessica, Syer, Tom J., Ta, Ngan Hong, Tadross, Daniel, Thompson, Benjamin, Trevett, Jess, Tyler, Matthew, Ullah, Roshan, Utukuri, Mrudula, Vadera, Shree, Van Den Tooren, Harriet, Venturini, Sara, Vijayakumar, Aradhya, Vine, Melanie, Wellbelove, Zoe, Wittner, Liora, Yong, Geoffrey Hong Kiat, Ziyada, Farris, and McManus, I. C.

Published
2020
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6. Additional file 4 of Exploring UK medical school differences: the MedDifs study of selection, teaching, student and F1 perceptions, postgraduate outcomes and fitness to practise

Author

McManus, I. C., Harborne, Andrew Christopher, Horsfall, Hugo Layard, Joseph, Tobin, Smith, Daniel T., Marshall-Andon, Tess, Samuels, Ryan, Kearsley, Joshua William, Abbas, Nadine, Baig, Hassan, Beecham, Joseph, Benons, Natasha, Caird, Charlie, Clark, Ryan, Cope, Thomas, Coultas, James, Debenham, Luke, Douglas, Sarah, Eldridge, Jack, Hughes-Gooding, Thomas, Jakubowska, Agnieszka, Jones, Oliver, Lancaster, Eve, MacMillan, Calum, McAllister, Ross, Merzougui, Wassim, Phillips, Ben, Phillips, Simon, Risk, Omar, Sage, Adam, Sooltangos, Aisha, Spencer, Robert, Tajbakhsh, Roxanne, Adesalu, Oluseyi, Aganin, Ivan, Ahmed, Ammar, Aiken, Katherine, Alimatu-Sadia Akeredolu, Alam, Ibrahim, Ali, Aamna, Anderson, Richard, Ang, Jia Jun, Anis, Fady Sameh, Sonam Aojula, Arthur, Catherine, Ashby, Alena, Ashraf, Ahmed, Aspinall, Emma, Awad, Mark, Yahaya, Abdul-Muiz Azri, Badhrinarayanan, Shreya, Bandyopadhyay, Soham, Barnes, Sam, Bassey-Duke, Daisy, Boreham, Charlotte, Braine, Rebecca, Brandreth, Joseph, Carrington, Zoe, Cashin, Zoe, Shaunak Chatterjee, Chawla, Mehar, Chean, Chung Shen, Clements, Chris, Clough, Richard, Coulthurst, Jessica, Curry, Liam, Daniels, Vinnie Christine, Davies, Simon, Davis, Rebecca, Waal, Hanelie De, Desai, Nasreen, Douglas, Hannah, Druce, James, Ejamike, Lady-Namera, Esere, Meron, Eyre, Alex, Fazmin, Ibrahim Talal, Fitzgerald-Smith, Sophia, Ford, Verity, Freeston, Sarah, Garnett, Katherine, General, Whitney, Gilbert, Helen, Gowie, Zein, Grafton-Clarke, Ciaran, Gudka, Keshni, Gumber, Leher, Gupta, Rishi, Harlow, Chris, Harrington, Amy, Heaney, Adele, Ho, Wing Hang Serene, Holloway, Lucy, Hood, Christina, Houghton, Eleanor, Houshangi, Saba, Howard, Emma, Human, Benjamin, Hunter, Harriet, Ifrah Hussain, Hussain, Sami, Jackson-Taylor, Richard Thomas, Jacob-Ramsdale, Bronwen, Janjuha, Ryan, Jawad, Saleh, Jelani, Muzzamil, Johnston, David, Jones, Mike, Kalidindi, Sadhana, Kalsi, Savraj, Kalyanasundaram, Asanish, Kane, Anna, Kaur, Sahaj, Al-Othman, Othman Khaled, Khan, Qaisar, Khullar, Sajan, Kirkland, Priscilla, Lawrence-Smith, Hannah, Leeson, Charlotte, Lenaerts, Julius Elisabeth Richard, Long, Kerry, Lubbock, Simon, Burrell, Jamie Mac Donald, Maguire, Rachel, Mahendran, Praveen, Majeed, Saad, Malhotra, Prabhjot Singh, Mandagere, Vinay, Mantelakis, Angelos, McGovern, Sophie, Mosuro, Anjola, Moxley, Adam, Mustoe, Sophie, Myers, Sam, Nadeem, Kiran, Nasseri, Reza, Newman, Tom, Nzewi, Richard, Ogborne, Rosalie, Omatseye, Joyce, Paddock, Sophie, Parkin, James, Patel, Mohit, Pawar, Sohini, Pearce, Stuart, Penrice, Samuel, Purdy, Julian, Ramjan, Raisa, Randhawa, Ratan, Rasul, Usman, Raymond-Taggert, Elliot, Razey, Rebecca, Razzaghi, Carmel, Reel, Eimear, Revell, Elliot John, Rigbye, Joanna, Rotimi, Oloruntobi, Said, Abdelrahman, Sanders, Emma, Sangal, Pranoy, Grandal, Nora Sangvik, Shah, Aadam, Shah, Rahul Atul, Shotton, Oliver, Sims, Daniel, Smart, Katie, Smith, Martha Amy, Smith, Nick, Aninditya Salma Sopian, South, Matthew, Speller, Jessica, Syer, Tom J., Ta, Ngan Hong, Tadross, Daniel, Thompson, Benjamin, Trevett, Jess, Tyler, Matthew, Ullah, Roshan, Utukuri, Mrudula, Vadera, Shree, Tooren, Harriet Van Den, Venturini, Sara, Vijayakumar, Aradhya, Vine, Melanie, Wellbelove, Zoe, Wittner, Liora, Yong, Geoffrey Hong Kiat, Ziyada, Farris, and Devine, Oliver Patrick

Abstract

Additional file 4. Graphs 1 to 210 (pages 1 to 35).

Published
2020
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7. Additional file 7 of Exploring UK medical school differences: the MedDifs study of selection, teaching, student and F1 perceptions, postgraduate outcomes and fitness to practise

Author

McManus, I. C., Harborne, Andrew Christopher, Horsfall, Hugo Layard, Joseph, Tobin, Smith, Daniel T., Marshall-Andon, Tess, Samuels, Ryan, Kearsley, Joshua William, Abbas, Nadine, Baig, Hassan, Beecham, Joseph, Benons, Natasha, Caird, Charlie, Clark, Ryan, Cope, Thomas, Coultas, James, Debenham, Luke, Douglas, Sarah, Eldridge, Jack, Hughes-Gooding, Thomas, Jakubowska, Agnieszka, Jones, Oliver, Lancaster, Eve, MacMillan, Calum, McAllister, Ross, Merzougui, Wassim, Phillips, Ben, Phillips, Simon, Risk, Omar, Sage, Adam, Sooltangos, Aisha, Spencer, Robert, Tajbakhsh, Roxanne, Adesalu, Oluseyi, Aganin, Ivan, Ahmed, Ammar, Aiken, Katherine, Alimatu-Sadia Akeredolu, Alam, Ibrahim, Ali, Aamna, Anderson, Richard, Ang, Jia Jun, Anis, Fady Sameh, Sonam Aojula, Arthur, Catherine, Ashby, Alena, Ashraf, Ahmed, Aspinall, Emma, Awad, Mark, Yahaya, Abdul-Muiz Azri, Badhrinarayanan, Shreya, Bandyopadhyay, Soham, Barnes, Sam, Bassey-Duke, Daisy, Boreham, Charlotte, Braine, Rebecca, Brandreth, Joseph, Carrington, Zoe, Cashin, Zoe, Shaunak Chatterjee, Chawla, Mehar, Chean, Chung Shen, Clements, Chris, Clough, Richard, Coulthurst, Jessica, Curry, Liam, Daniels, Vinnie Christine, Davies, Simon, Davis, Rebecca, Waal, Hanelie De, Desai, Nasreen, Douglas, Hannah, Druce, James, Ejamike, Lady-Namera, Esere, Meron, Eyre, Alex, Fazmin, Ibrahim Talal, Fitzgerald-Smith, Sophia, Ford, Verity, Freeston, Sarah, Garnett, Katherine, General, Whitney, Gilbert, Helen, Gowie, Zein, Grafton-Clarke, Ciaran, Gudka, Keshni, Gumber, Leher, Gupta, Rishi, Harlow, Chris, Harrington, Amy, Heaney, Adele, Ho, Wing Hang Serene, Holloway, Lucy, Hood, Christina, Houghton, Eleanor, Houshangi, Saba, Howard, Emma, Human, Benjamin, Hunter, Harriet, Ifrah Hussain, Hussain, Sami, Jackson-Taylor, Richard Thomas, Jacob-Ramsdale, Bronwen, Janjuha, Ryan, Jawad, Saleh, Jelani, Muzzamil, Johnston, David, Jones, Mike, Kalidindi, Sadhana, Kalsi, Savraj, Kalyanasundaram, Asanish, Kane, Anna, Kaur, Sahaj, Al-Othman, Othman Khaled, Khan, Qaisar, Khullar, Sajan, Kirkland, Priscilla, Lawrence-Smith, Hannah, Leeson, Charlotte, Lenaerts, Julius Elisabeth Richard, Long, Kerry, Lubbock, Simon, Burrell, Jamie Mac Donald, Maguire, Rachel, Mahendran, Praveen, Majeed, Saad, Malhotra, Prabhjot Singh, Mandagere, Vinay, Mantelakis, Angelos, McGovern, Sophie, Mosuro, Anjola, Moxley, Adam, Mustoe, Sophie, Myers, Sam, Nadeem, Kiran, Nasseri, Reza, Newman, Tom, Nzewi, Richard, Ogborne, Rosalie, Omatseye, Joyce, Paddock, Sophie, Parkin, James, Patel, Mohit, Pawar, Sohini, Pearce, Stuart, Penrice, Samuel, Purdy, Julian, Ramjan, Raisa, Randhawa, Ratan, Rasul, Usman, Raymond-Taggert, Elliot, Razey, Rebecca, Razzaghi, Carmel, Reel, Eimear, Revell, Elliot John, Rigbye, Joanna, Rotimi, Oloruntobi, Said, Abdelrahman, Sanders, Emma, Sangal, Pranoy, Grandal, Nora Sangvik, Shah, Aadam, Shah, Rahul Atul, Shotton, Oliver, Sims, Daniel, Smart, Katie, Smith, Martha Amy, Smith, Nick, Aninditya Salma Sopian, South, Matthew, Speller, Jessica, Syer, Tom J., Ta, Ngan Hong, Tadross, Daniel, Thompson, Benjamin, Trevett, Jess, Tyler, Matthew, Ullah, Roshan, Utukuri, Mrudula, Vadera, Shree, Tooren, Harriet Van Den, Venturini, Sara, Vijayakumar, Aradhya, Vine, Melanie, Wellbelove, Zoe, Wittner, Liora, Yong, Geoffrey Hong Kiat, Ziyada, Farris, and Devine, Oliver Patrick

Abstract

Additional file 7. Graphs 631 to 840 (pages 106 to 140).

Published
2020
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8. Additional file 6 of Exploring UK medical school differences: the MedDifs study of selection, teaching, student and F1 perceptions, postgraduate outcomes and fitness to practise

Author

McManus, I. C., Harborne, Andrew Christopher, Horsfall, Hugo Layard, Joseph, Tobin, Smith, Daniel T., Marshall-Andon, Tess, Samuels, Ryan, Kearsley, Joshua William, Abbas, Nadine, Baig, Hassan, Beecham, Joseph, Benons, Natasha, Caird, Charlie, Clark, Ryan, Cope, Thomas, Coultas, James, Debenham, Luke, Douglas, Sarah, Eldridge, Jack, Hughes-Gooding, Thomas, Jakubowska, Agnieszka, Jones, Oliver, Lancaster, Eve, MacMillan, Calum, McAllister, Ross, Merzougui, Wassim, Phillips, Ben, Phillips, Simon, Risk, Omar, Sage, Adam, Sooltangos, Aisha, Spencer, Robert, Tajbakhsh, Roxanne, Adesalu, Oluseyi, Aganin, Ivan, Ahmed, Ammar, Aiken, Katherine, Alimatu-Sadia Akeredolu, Alam, Ibrahim, Ali, Aamna, Anderson, Richard, Ang, Jia Jun, Anis, Fady Sameh, Sonam Aojula, Arthur, Catherine, Ashby, Alena, Ashraf, Ahmed, Aspinall, Emma, Awad, Mark, Yahaya, Abdul-Muiz Azri, Badhrinarayanan, Shreya, Bandyopadhyay, Soham, Barnes, Sam, Bassey-Duke, Daisy, Boreham, Charlotte, Braine, Rebecca, Brandreth, Joseph, Carrington, Zoe, Cashin, Zoe, Shaunak Chatterjee, Chawla, Mehar, Chean, Chung Shen, Clements, Chris, Clough, Richard, Coulthurst, Jessica, Curry, Liam, Daniels, Vinnie Christine, Davies, Simon, Davis, Rebecca, Waal, Hanelie De, Desai, Nasreen, Douglas, Hannah, Druce, James, Ejamike, Lady-Namera, Esere, Meron, Eyre, Alex, Fazmin, Ibrahim Talal, Fitzgerald-Smith, Sophia, Ford, Verity, Freeston, Sarah, Garnett, Katherine, General, Whitney, Gilbert, Helen, Gowie, Zein, Grafton-Clarke, Ciaran, Gudka, Keshni, Gumber, Leher, Gupta, Rishi, Harlow, Chris, Harrington, Amy, Heaney, Adele, Ho, Wing Hang Serene, Holloway, Lucy, Hood, Christina, Houghton, Eleanor, Houshangi, Saba, Howard, Emma, Human, Benjamin, Hunter, Harriet, Ifrah Hussain, Hussain, Sami, Jackson-Taylor, Richard Thomas, Jacob-Ramsdale, Bronwen, Janjuha, Ryan, Jawad, Saleh, Jelani, Muzzamil, Johnston, David, Jones, Mike, Kalidindi, Sadhana, Kalsi, Savraj, Kalyanasundaram, Asanish, Kane, Anna, Kaur, Sahaj, Al-Othman, Othman Khaled, Khan, Qaisar, Khullar, Sajan, Kirkland, Priscilla, Lawrence-Smith, Hannah, Leeson, Charlotte, Lenaerts, Julius Elisabeth Richard, Long, Kerry, Lubbock, Simon, Burrell, Jamie Mac Donald, Maguire, Rachel, Mahendran, Praveen, Majeed, Saad, Malhotra, Prabhjot Singh, Mandagere, Vinay, Mantelakis, Angelos, McGovern, Sophie, Mosuro, Anjola, Moxley, Adam, Mustoe, Sophie, Myers, Sam, Nadeem, Kiran, Nasseri, Reza, Newman, Tom, Nzewi, Richard, Ogborne, Rosalie, Omatseye, Joyce, Paddock, Sophie, Parkin, James, Patel, Mohit, Pawar, Sohini, Pearce, Stuart, Penrice, Samuel, Purdy, Julian, Ramjan, Raisa, Randhawa, Ratan, Rasul, Usman, Raymond-Taggert, Elliot, Razey, Rebecca, Razzaghi, Carmel, Reel, Eimear, Revell, Elliot John, Rigbye, Joanna, Rotimi, Oloruntobi, Said, Abdelrahman, Sanders, Emma, Sangal, Pranoy, Grandal, Nora Sangvik, Shah, Aadam, Shah, Rahul Atul, Shotton, Oliver, Sims, Daniel, Smart, Katie, Smith, Martha Amy, Smith, Nick, Aninditya Salma Sopian, South, Matthew, Speller, Jessica, Syer, Tom J., Ta, Ngan Hong, Tadross, Daniel, Thompson, Benjamin, Trevett, Jess, Tyler, Matthew, Ullah, Roshan, Utukuri, Mrudula, Vadera, Shree, Tooren, Harriet Van Den, Venturini, Sara, Vijayakumar, Aradhya, Vine, Melanie, Wellbelove, Zoe, Wittner, Liora, Yong, Geoffrey Hong Kiat, Ziyada, Farris, and Devine, Oliver Patrick

Abstract

Additional file 6. Graphs 421 to 630 (pages 71 to 105).

Published
2020
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9. Additional file 8 of Exploring UK medical school differences: the MedDifs study of selection, teaching, student and F1 perceptions, postgraduate outcomes and fitness to practise

Author

McManus, I. C., Harborne, Andrew Christopher, Horsfall, Hugo Layard, Joseph, Tobin, Smith, Daniel T., Marshall-Andon, Tess, Samuels, Ryan, Kearsley, Joshua William, Abbas, Nadine, Baig, Hassan, Beecham, Joseph, Benons, Natasha, Caird, Charlie, Clark, Ryan, Cope, Thomas, Coultas, James, Debenham, Luke, Douglas, Sarah, Eldridge, Jack, Hughes-Gooding, Thomas, Jakubowska, Agnieszka, Jones, Oliver, Lancaster, Eve, MacMillan, Calum, McAllister, Ross, Merzougui, Wassim, Phillips, Ben, Phillips, Simon, Risk, Omar, Sage, Adam, Sooltangos, Aisha, Spencer, Robert, Tajbakhsh, Roxanne, Adesalu, Oluseyi, Aganin, Ivan, Ahmed, Ammar, Aiken, Katherine, Alimatu-Sadia Akeredolu, Alam, Ibrahim, Ali, Aamna, Anderson, Richard, Ang, Jia Jun, Anis, Fady Sameh, Sonam Aojula, Arthur, Catherine, Ashby, Alena, Ashraf, Ahmed, Aspinall, Emma, Awad, Mark, Yahaya, Abdul-Muiz Azri, Badhrinarayanan, Shreya, Bandyopadhyay, Soham, Barnes, Sam, Bassey-Duke, Daisy, Boreham, Charlotte, Braine, Rebecca, Brandreth, Joseph, Carrington, Zoe, Cashin, Zoe, Shaunak Chatterjee, Chawla, Mehar, Chean, Chung Shen, Clements, Chris, Clough, Richard, Coulthurst, Jessica, Curry, Liam, Daniels, Vinnie Christine, Davies, Simon, Davis, Rebecca, Waal, Hanelie De, Desai, Nasreen, Douglas, Hannah, Druce, James, Ejamike, Lady-Namera, Esere, Meron, Eyre, Alex, Fazmin, Ibrahim Talal, Fitzgerald-Smith, Sophia, Ford, Verity, Freeston, Sarah, Garnett, Katherine, General, Whitney, Gilbert, Helen, Gowie, Zein, Grafton-Clarke, Ciaran, Gudka, Keshni, Gumber, Leher, Gupta, Rishi, Harlow, Chris, Harrington, Amy, Heaney, Adele, Ho, Wing Hang Serene, Holloway, Lucy, Hood, Christina, Houghton, Eleanor, Houshangi, Saba, Howard, Emma, Human, Benjamin, Hunter, Harriet, Ifrah Hussain, Hussain, Sami, Jackson-Taylor, Richard Thomas, Jacob-Ramsdale, Bronwen, Janjuha, Ryan, Jawad, Saleh, Jelani, Muzzamil, Johnston, David, Jones, Mike, Kalidindi, Sadhana, Kalsi, Savraj, Kalyanasundaram, Asanish, Kane, Anna, Kaur, Sahaj, Al-Othman, Othman Khaled, Khan, Qaisar, Khullar, Sajan, Kirkland, Priscilla, Lawrence-Smith, Hannah, Leeson, Charlotte, Lenaerts, Julius Elisabeth Richard, Long, Kerry, Lubbock, Simon, Burrell, Jamie Mac Donald, Maguire, Rachel, Mahendran, Praveen, Majeed, Saad, Malhotra, Prabhjot Singh, Mandagere, Vinay, Mantelakis, Angelos, McGovern, Sophie, Mosuro, Anjola, Moxley, Adam, Mustoe, Sophie, Myers, Sam, Nadeem, Kiran, Nasseri, Reza, Newman, Tom, Nzewi, Richard, Ogborne, Rosalie, Omatseye, Joyce, Paddock, Sophie, Parkin, James, Patel, Mohit, Pawar, Sohini, Pearce, Stuart, Penrice, Samuel, Purdy, Julian, Ramjan, Raisa, Randhawa, Ratan, Rasul, Usman, Raymond-Taggert, Elliot, Razey, Rebecca, Razzaghi, Carmel, Reel, Eimear, Revell, Elliot John, Rigbye, Joanna, Rotimi, Oloruntobi, Said, Abdelrahman, Sanders, Emma, Sangal, Pranoy, Grandal, Nora Sangvik, Shah, Aadam, Shah, Rahul Atul, Shotton, Oliver, Sims, Daniel, Smart, Katie, Smith, Martha Amy, Smith, Nick, Aninditya Salma Sopian, South, Matthew, Speller, Jessica, Syer, Tom J., Ta, Ngan Hong, Tadross, Daniel, Thompson, Benjamin, Trevett, Jess, Tyler, Matthew, Ullah, Roshan, Utukuri, Mrudula, Vadera, Shree, Tooren, Harriet Van Den, Venturini, Sara, Vijayakumar, Aradhya, Vine, Melanie, Wellbelove, Zoe, Wittner, Liora, Yong, Geoffrey Hong Kiat, Ziyada, Farris, and Devine, Oliver Patrick

Abstract

Additional file 8. Graphs 841 to 1050 (pages 141 to 175).

Published
2020
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10. Additional file 1 of Exploring UK medical school differences: the MedDifs study of selection, teaching, student and F1 perceptions, postgraduate outcomes and fitness to practise

Author

McManus, I. C., Harborne, Andrew Christopher, Horsfall, Hugo Layard, Joseph, Tobin, Smith, Daniel T., Marshall-Andon, Tess, Samuels, Ryan, Kearsley, Joshua William, Abbas, Nadine, Baig, Hassan, Beecham, Joseph, Benons, Natasha, Caird, Charlie, Clark, Ryan, Cope, Thomas, Coultas, James, Debenham, Luke, Douglas, Sarah, Eldridge, Jack, Hughes-Gooding, Thomas, Jakubowska, Agnieszka, Jones, Oliver, Lancaster, Eve, MacMillan, Calum, McAllister, Ross, Merzougui, Wassim, Phillips, Ben, Phillips, Simon, Risk, Omar, Sage, Adam, Sooltangos, Aisha, Spencer, Robert, Tajbakhsh, Roxanne, Adesalu, Oluseyi, Aganin, Ivan, Ahmed, Ammar, Aiken, Katherine, Alimatu-Sadia Akeredolu, Alam, Ibrahim, Ali, Aamna, Anderson, Richard, Ang, Jia Jun, Anis, Fady Sameh, Sonam Aojula, Arthur, Catherine, Ashby, Alena, Ashraf, Ahmed, Aspinall, Emma, Awad, Mark, Yahaya, Abdul-Muiz Azri, Badhrinarayanan, Shreya, Bandyopadhyay, Soham, Barnes, Sam, Bassey-Duke, Daisy, Boreham, Charlotte, Braine, Rebecca, Brandreth, Joseph, Carrington, Zoe, Cashin, Zoe, Shaunak Chatterjee, Chawla, Mehar, Chean, Chung Shen, Clements, Chris, Clough, Richard, Coulthurst, Jessica, Curry, Liam, Daniels, Vinnie Christine, Davies, Simon, Davis, Rebecca, Waal, Hanelie De, Desai, Nasreen, Douglas, Hannah, Druce, James, Ejamike, Lady-Namera, Esere, Meron, Eyre, Alex, Fazmin, Ibrahim Talal, Fitzgerald-Smith, Sophia, Ford, Verity, Freeston, Sarah, Garnett, Katherine, General, Whitney, Gilbert, Helen, Gowie, Zein, Grafton-Clarke, Ciaran, Gudka, Keshni, Gumber, Leher, Gupta, Rishi, Harlow, Chris, Harrington, Amy, Heaney, Adele, Ho, Wing Hang Serene, Holloway, Lucy, Hood, Christina, Houghton, Eleanor, Houshangi, Saba, Howard, Emma, Human, Benjamin, Hunter, Harriet, Ifrah Hussain, Hussain, Sami, Jackson-Taylor, Richard Thomas, Jacob-Ramsdale, Bronwen, Janjuha, Ryan, Jawad, Saleh, Jelani, Muzzamil, Johnston, David, Jones, Mike, Kalidindi, Sadhana, Kalsi, Savraj, Kalyanasundaram, Asanish, Kane, Anna, Kaur, Sahaj, Al-Othman, Othman Khaled, Khan, Qaisar, Khullar, Sajan, Kirkland, Priscilla, Lawrence-Smith, Hannah, Leeson, Charlotte, Lenaerts, Julius Elisabeth Richard, Long, Kerry, Lubbock, Simon, Burrell, Jamie Mac Donald, Maguire, Rachel, Mahendran, Praveen, Majeed, Saad, Malhotra, Prabhjot Singh, Mandagere, Vinay, Mantelakis, Angelos, McGovern, Sophie, Mosuro, Anjola, Moxley, Adam, Mustoe, Sophie, Myers, Sam, Nadeem, Kiran, Nasseri, Reza, Newman, Tom, Nzewi, Richard, Ogborne, Rosalie, Omatseye, Joyce, Paddock, Sophie, Parkin, James, Patel, Mohit, Pawar, Sohini, Pearce, Stuart, Penrice, Samuel, Purdy, Julian, Ramjan, Raisa, Randhawa, Ratan, Rasul, Usman, Raymond-Taggert, Elliot, Razey, Rebecca, Razzaghi, Carmel, Reel, Eimear, Revell, Elliot John, Rigbye, Joanna, Rotimi, Oloruntobi, Said, Abdelrahman, Sanders, Emma, Sangal, Pranoy, Grandal, Nora Sangvik, Shah, Aadam, Shah, Rahul Atul, Shotton, Oliver, Sims, Daniel, Smart, Katie, Smith, Martha Amy, Smith, Nick, Aninditya Salma Sopian, South, Matthew, Speller, Jessica, Syer, Tom J., Ta, Ngan Hong, Tadross, Daniel, Thompson, Benjamin, Trevett, Jess, Tyler, Matthew, Ullah, Roshan, Utukuri, Mrudula, Vadera, Shree, Tooren, Harriet Van Den, Venturini, Sara, Vijayakumar, Aradhya, Vine, Melanie, Wellbelove, Zoe, Wittner, Liora, Yong, Geoffrey Hong Kiat, Ziyada, Farris, and Devine, Oliver Patrick

Abstract

Additional file 1. Figures S1 to S10, and additional text on the causal ordering of variables.

Published
2020
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11. Additional file 5 of Exploring UK medical school differences: the MedDifs study of selection, teaching, student and F1 perceptions, postgraduate outcomes and fitness to practise

Author

McManus, I. C., Harborne, Andrew Christopher, Horsfall, Hugo Layard, Joseph, Tobin, Smith, Daniel T., Marshall-Andon, Tess, Samuels, Ryan, Kearsley, Joshua William, Abbas, Nadine, Baig, Hassan, Beecham, Joseph, Benons, Natasha, Caird, Charlie, Clark, Ryan, Cope, Thomas, Coultas, James, Debenham, Luke, Douglas, Sarah, Eldridge, Jack, Hughes-Gooding, Thomas, Jakubowska, Agnieszka, Jones, Oliver, Lancaster, Eve, MacMillan, Calum, McAllister, Ross, Merzougui, Wassim, Phillips, Ben, Phillips, Simon, Risk, Omar, Sage, Adam, Sooltangos, Aisha, Spencer, Robert, Tajbakhsh, Roxanne, Adesalu, Oluseyi, Aganin, Ivan, Ahmed, Ammar, Aiken, Katherine, Alimatu-Sadia Akeredolu, Alam, Ibrahim, Ali, Aamna, Anderson, Richard, Ang, Jia Jun, Anis, Fady Sameh, Sonam Aojula, Arthur, Catherine, Ashby, Alena, Ashraf, Ahmed, Aspinall, Emma, Awad, Mark, Yahaya, Abdul-Muiz Azri, Badhrinarayanan, Shreya, Bandyopadhyay, Soham, Barnes, Sam, Bassey-Duke, Daisy, Boreham, Charlotte, Braine, Rebecca, Brandreth, Joseph, Carrington, Zoe, Cashin, Zoe, Shaunak Chatterjee, Chawla, Mehar, Chean, Chung Shen, Clements, Chris, Clough, Richard, Coulthurst, Jessica, Curry, Liam, Daniels, Vinnie Christine, Davies, Simon, Davis, Rebecca, Waal, Hanelie De, Desai, Nasreen, Douglas, Hannah, Druce, James, Ejamike, Lady-Namera, Esere, Meron, Eyre, Alex, Fazmin, Ibrahim Talal, Fitzgerald-Smith, Sophia, Ford, Verity, Freeston, Sarah, Garnett, Katherine, General, Whitney, Gilbert, Helen, Gowie, Zein, Grafton-Clarke, Ciaran, Gudka, Keshni, Gumber, Leher, Gupta, Rishi, Harlow, Chris, Harrington, Amy, Heaney, Adele, Ho, Wing Hang Serene, Holloway, Lucy, Hood, Christina, Houghton, Eleanor, Houshangi, Saba, Howard, Emma, Human, Benjamin, Hunter, Harriet, Ifrah Hussain, Hussain, Sami, Jackson-Taylor, Richard Thomas, Jacob-Ramsdale, Bronwen, Janjuha, Ryan, Jawad, Saleh, Jelani, Muzzamil, Johnston, David, Jones, Mike, Kalidindi, Sadhana, Kalsi, Savraj, Kalyanasundaram, Asanish, Kane, Anna, Kaur, Sahaj, Al-Othman, Othman Khaled, Khan, Qaisar, Khullar, Sajan, Kirkland, Priscilla, Lawrence-Smith, Hannah, Leeson, Charlotte, Lenaerts, Julius Elisabeth Richard, Long, Kerry, Lubbock, Simon, Burrell, Jamie Mac Donald, Maguire, Rachel, Mahendran, Praveen, Majeed, Saad, Malhotra, Prabhjot Singh, Mandagere, Vinay, Mantelakis, Angelos, McGovern, Sophie, Mosuro, Anjola, Moxley, Adam, Mustoe, Sophie, Myers, Sam, Nadeem, Kiran, Nasseri, Reza, Newman, Tom, Nzewi, Richard, Ogborne, Rosalie, Omatseye, Joyce, Paddock, Sophie, Parkin, James, Patel, Mohit, Pawar, Sohini, Pearce, Stuart, Penrice, Samuel, Purdy, Julian, Ramjan, Raisa, Randhawa, Ratan, Rasul, Usman, Raymond-Taggert, Elliot, Razey, Rebecca, Razzaghi, Carmel, Reel, Eimear, Revell, Elliot John, Rigbye, Joanna, Rotimi, Oloruntobi, Said, Abdelrahman, Sanders, Emma, Sangal, Pranoy, Grandal, Nora Sangvik, Shah, Aadam, Shah, Rahul Atul, Shotton, Oliver, Sims, Daniel, Smart, Katie, Smith, Martha Amy, Smith, Nick, Aninditya Salma Sopian, South, Matthew, Speller, Jessica, Syer, Tom J., Ta, Ngan Hong, Tadross, Daniel, Thompson, Benjamin, Trevett, Jess, Tyler, Matthew, Ullah, Roshan, Utukuri, Mrudula, Vadera, Shree, Tooren, Harriet Van Den, Venturini, Sara, Vijayakumar, Aradhya, Vine, Melanie, Wellbelove, Zoe, Wittner, Liora, Yong, Geoffrey Hong Kiat, Ziyada, Farris, and Devine, Oliver Patrick

Abstract

Additional file 5. Graphs 211 to 420 (pages 36 to 70).

Published
2020
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12. Additional file 3 of Exploring UK medical school differences: the MedDifs study of selection, teaching, student and F1 perceptions, postgraduate outcomes and fitness to practise

Author

McManus, I. C., Harborne, Andrew Christopher, Horsfall, Hugo Layard, Joseph, Tobin, Smith, Daniel T., Marshall-Andon, Tess, Samuels, Ryan, Kearsley, Joshua William, Abbas, Nadine, Baig, Hassan, Beecham, Joseph, Benons, Natasha, Caird, Charlie, Clark, Ryan, Cope, Thomas, Coultas, James, Debenham, Luke, Douglas, Sarah, Eldridge, Jack, Hughes-Gooding, Thomas, Jakubowska, Agnieszka, Jones, Oliver, Lancaster, Eve, MacMillan, Calum, McAllister, Ross, Merzougui, Wassim, Phillips, Ben, Phillips, Simon, Risk, Omar, Sage, Adam, Sooltangos, Aisha, Spencer, Robert, Tajbakhsh, Roxanne, Adesalu, Oluseyi, Aganin, Ivan, Ahmed, Ammar, Aiken, Katherine, Alimatu-Sadia Akeredolu, Alam, Ibrahim, Ali, Aamna, Anderson, Richard, Ang, Jia Jun, Anis, Fady Sameh, Sonam Aojula, Arthur, Catherine, Ashby, Alena, Ashraf, Ahmed, Aspinall, Emma, Awad, Mark, Yahaya, Abdul-Muiz Azri, Badhrinarayanan, Shreya, Bandyopadhyay, Soham, Barnes, Sam, Bassey-Duke, Daisy, Boreham, Charlotte, Braine, Rebecca, Brandreth, Joseph, Carrington, Zoe, Cashin, Zoe, Shaunak Chatterjee, Chawla, Mehar, Chean, Chung Shen, Clements, Chris, Clough, Richard, Coulthurst, Jessica, Curry, Liam, Daniels, Vinnie Christine, Davies, Simon, Davis, Rebecca, Waal, Hanelie De, Desai, Nasreen, Douglas, Hannah, Druce, James, Ejamike, Lady-Namera, Esere, Meron, Eyre, Alex, Fazmin, Ibrahim Talal, Fitzgerald-Smith, Sophia, Ford, Verity, Freeston, Sarah, Garnett, Katherine, General, Whitney, Gilbert, Helen, Gowie, Zein, Grafton-Clarke, Ciaran, Gudka, Keshni, Gumber, Leher, Gupta, Rishi, Harlow, Chris, Harrington, Amy, Heaney, Adele, Ho, Wing Hang Serene, Holloway, Lucy, Hood, Christina, Houghton, Eleanor, Houshangi, Saba, Howard, Emma, Human, Benjamin, Hunter, Harriet, Ifrah Hussain, Hussain, Sami, Jackson-Taylor, Richard Thomas, Jacob-Ramsdale, Bronwen, Janjuha, Ryan, Jawad, Saleh, Jelani, Muzzamil, Johnston, David, Jones, Mike, Kalidindi, Sadhana, Kalsi, Savraj, Kalyanasundaram, Asanish, Kane, Anna, Kaur, Sahaj, Al-Othman, Othman Khaled, Khan, Qaisar, Khullar, Sajan, Kirkland, Priscilla, Lawrence-Smith, Hannah, Leeson, Charlotte, Lenaerts, Julius Elisabeth Richard, Long, Kerry, Lubbock, Simon, Burrell, Jamie Mac Donald, Maguire, Rachel, Mahendran, Praveen, Majeed, Saad, Malhotra, Prabhjot Singh, Mandagere, Vinay, Mantelakis, Angelos, McGovern, Sophie, Mosuro, Anjola, Moxley, Adam, Mustoe, Sophie, Myers, Sam, Nadeem, Kiran, Nasseri, Reza, Newman, Tom, Nzewi, Richard, Ogborne, Rosalie, Omatseye, Joyce, Paddock, Sophie, Parkin, James, Patel, Mohit, Pawar, Sohini, Pearce, Stuart, Penrice, Samuel, Purdy, Julian, Ramjan, Raisa, Randhawa, Ratan, Rasul, Usman, Raymond-Taggert, Elliot, Razey, Rebecca, Razzaghi, Carmel, Reel, Eimear, Revell, Elliot John, Rigbye, Joanna, Rotimi, Oloruntobi, Said, Abdelrahman, Sanders, Emma, Sangal, Pranoy, Grandal, Nora Sangvik, Shah, Aadam, Shah, Rahul Atul, Shotton, Oliver, Sims, Daniel, Smart, Katie, Smith, Martha Amy, Smith, Nick, Aninditya Salma Sopian, South, Matthew, Speller, Jessica, Syer, Tom J., Ta, Ngan Hong, Tadross, Daniel, Thompson, Benjamin, Trevett, Jess, Tyler, Matthew, Ullah, Roshan, Utukuri, Mrudula, Vadera, Shree, Tooren, Harriet Van Den, Venturini, Sara, Vijayakumar, Aradhya, Vine, Melanie, Wellbelove, Zoe, Wittner, Liora, Yong, Geoffrey Hong Kiat, Ziyada, Farris, and Devine, Oliver Patrick

Abstract

Additional file 3. Index and notes on supplementary graphs 1 to 205 (page 1 to 205).

Published
2020
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15. Simvastatin Inhibits L-Type Ca 2+ -Channel Activity Through Impairment of Mitochondrial Function.

Author

Curry, Liam, Almukhtar, Hani, Alahmed, Jala, Roberts, Richard, and Smith, Paul A

Subjects
*SIMVASTATIN, *GLUCOSE intolerance, *MITOCHONDRIAL membranes, *MEMBRANE potential, *ION channels, *ADENOSINE diphosphate
Abstract

Plasma membrane ion channels and mitochondrial electron transport complexes (mETC) are recognized "off targets" for certain drugs. Simvastatin is one such drug, a lipophilic statin used to treat hypercholesterolemia, but which is also associated with adverse effects like myopathy and increased risk of glucose intolerance. Such myopathy is thought to arise through adverse actions of simvastatin on skeletal muscle mETC and mitochondrial respiration. In this study, we investigated whether the glucose intolerance associated with simvastatin is also mediated via adverse effects on mETC in pancreatic beta-cells because mitochondrial respiration underlies insulin secretion from these cells, an effect in part mediated by promotion of Ca2+ influx via opening of voltage-gated Ca2+ channels (VGCCs). We used murine pancreatic beta-cells to investigate these ideas. Mitochondrial membrane potential, oxygen consumption, and ATP-sensitive-K+-channel activity were monitored as markers of mETC activity, respiration, and cellular ATP/ADP ratio respectively; Ca2+ channel activity and Ca2+ influx were also measured. In intact beta-cells, simvastatin inhibited oxidative respiration (IC50 approximately 3 µM) and mETC (1 < IC50 < 10 µM), effects expected to impair VGCC opening. Consistent with this idea simvastatin > 0.1 µM reversed activation of VGCCs by glucose but had no significant effect in the sugar's absence. The VGCC effects were mimicked by rotenone which also decreased respiration and ATP/ADP. This study demonstrates modulation of beta-cell VGCC activity by mitochondrial respiration and their sensitivity to mETC inhibitors. This reveals a novel outcome for the action of drugs like simvastatin for which mETC is an "off target". [ABSTRACT FROM AUTHOR]

Published
2019
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16. Exploring UK medical school differences: the MedDifs study of selection, teaching, student and F1 perceptions, postgraduate outcomes and fitness to practise

Author

Richard Nzewi, Luke Debenham, Calum MacMillan, Kiran Nadeem, Zoe Carrington, Omar Risk, Rebecca Razey, James Parkin, Sam Myers, Asanish Kalyanasundaram, Mark Awad, Zein Gowie, Julian Purdy, Simon E. V. Phillips, Zoe Wellbelove, Mike Jones, Priscilla Kirkland, Nadine Abbas, Oluseyi Adesalu, Roxanne Tajbakhsh, Oliver Shotton, Adele Heaney, Joseph Brandreth, Benjamin Human, Jamie Mac Donald Burrell, Benjamin Thompson, Wassim Merzougui, Chris Harlow, Matthew South, Angelos Mantelakis, Nora Sangvik Grandal, Samuel C. Barnes, Daniel Sims, Fady Sameh Anis, Hannah Lawrence-Smith, Thomas P. W. Cope, Farris Ziyada, Saad Majeed, Carmel Razzaghi, Jack Eldridge, Rachel Maguire, Amy Harrington, Simon Lubbock, Abdul Muiz Azri Yahaya, Roshan Ullah, Oliver P. Devine, Zoe Cashin, Usman Rasul, Daniel Tadross, Pranoy Sangal, Ngan Hong Ta, Ammar Ahmed, Mehar Chawla, Sarah Freeston, Hugo Layard Horsfall, Sohini Pawar, Eve Lancaster, Harriet Hunter, Richard Clough, Alex Eyre, Sonam Aojula, Prabhjot Singh Malhotra, Elliot Raymond-Taggert, Ciaran Grafton-Clarke, Abdelrahman Said, Katherine Aiken, Ryan Janjuha, Adam Sage, Wing Hang Serene Ho, Shree Vadera, Joyce Omatseye, Aninditya Salma Sopian, Daisy Bassey-Duke, Samuel Penrice, Tom Newman, Sarah Douglas, Helen Gilbert, Jia Jun Ang, Aisha Sooltangos, Leher Gumber, Raisa Ramjan, Nasreen Desai, Shaunak Chatterjee, Oloruntobi Rotimi, Shreya Badhrinarayanan, Chris Clements, Harriet Van Den Tooren, Bronwen Jacob-Ramsdale, Savraj Kalsi, Mrudula Utukuri, Soham Bandyopadhyay, Eleanor Houghton, Meron Esere, Sadhana Kalidindi, Chung Shen Chean, James Coultas, Emma Sanders, Jessica Coulthurst, Ahmed Ashraf, Nick Smith, Whitney General, Katherine Garnett, Emma L Howard, Joanna Rigbye, Rebecca Braine, Saba Houshangi, Christina Hood, Aadam Shah, Praveen Mahendran, Ifrah Hussain, Ben Phillips, Keshni Gudka, Alimatu Sadia Akeredolu, Reza Nasseri, Tobin Joseph, Vinay Mandagere, Charlotte Leeson, Jess Trevett, Anjola Mosuro, Othman Khaled Al-Othman, Thomas Hughes-Gooding, Eimear Reel, Vinnie Christine Daniels, Liora Wittner, Sophie Paddock, Verity Ford, Daniel Smith, Sara Venturini, Rahul Atul Shah, Martha Amy Smith, Matthew Tyler, Charlotte Boreham, Ratan Randhawa, Katie Smart, Richard Thomas Jackson-Taylor, Agnieszka Jakubowska, Andrew Christopher Harborne, Jessica Speller, Sophie Mustoe, Ibrahim Alam, Richard B. Anderson, Mohit Patel, Tess Marshall-Andon, Liam Curry, Elliot John Revell, Sami Hussain, Hassan Baig, Geoffrey Hong Kiat Yong, Emma Aspinall, Robert Spencer, Sajan Khullar, Ryan Samuels, Saleh Jawad, Oliver Jones, Ivan Aganin, Rebecca Davis, Hanelie De Waal, I. C. McManus, Ryan Clark, Adam Moxley, Charlie Caird, Ibrahim T. Fazmin, Natasha Benons, Rosalie Ogborne, Rishi K Gupta, Sahaj Kaur, Melanie Vine, Muzzamil Jelani, James Druce, Julius Elisabeth Richard Lenaerts, Anna Kane, Lucy Holloway, Lady Namera Ejamike, Tom Joseph Syer, Alena Ashby, Sophie McGovern, Simon Davies, Sophia Fitzgerald-Smith, Aradhya Vijayakumar, Stuart Pearce, Kerry Long, Joseph Beecham, Catherine Arthur, Qaisar Khan, Joshua William Kearsley, David Johnston, Ross McAllister, Hannah Douglas, Aamna Ali, McManus, I. C. [0000-0003-3510-4814], Harborne, Andrew Christopher [0000-0003-0937-1492], Horsfall, Hugo Layard [0000-0001-7848-5325], Joseph, Tobin [0000-0002-9283-9895], Smith, Daniel T. [0000-0003-1215-5811], Marshall-Andon, Tess [0000-0001-8909-1639], Samuels, Ryan [0000-0002-0886-7990], Abbas, Nadine [0000-0002-9116-2915], Baig, Hassan [0000-0001-8999-0474], Beecham, Joseph [0000-0002-4390-9164], Benons, Natasha [0000-0002-0750-6560], Caird, Charlie [0000-0001-7553-5585], Clark, Ryan [0000-0002-6143-9098], Cope, Thomas [0000-0003-0247-7411], Coultas, James [0000-0003-3381-8936], Debenham, Luke [0000-0002-3300-7802], Douglas, Sarah [0000-0003-3272-8154], Eldridge, Jack [0000-0001-6792-7714], Hughes-Gooding, Thomas [0000-0001-8483-5686], Jakubowska, Agnieszka [0000-0003-3153-8666], Jones, Oliver [0000-0003-4334-3567], Lancaster, Eve [0000-0001-5703-252X], MacMillan, Calum [0000-0002-8167-0051], McAllister, Ross [0000-0003-1686-1174], Merzougui, Wassim [0000-0001-7398-0095], Phillips, Ben [0000-0002-0489-6700], Risk, Omar [0000-0002-9226-9263], Sage, Adam [0000-0002-7763-404X], Sooltangos, Aisha [0000-0001-5675-1709], Spencer, Robert [0000-0001-9045-6260], Tajbakhsh, 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Praveen [0000-0002-4084-5222], Majeed, Saad [0000-0003-4289-5597], Malhotra, Prabhjot Singh [0000-0001-7463-3941], Mandagere, Vinay [0000-0002-2969-6457], Mantelakis, Angelos [0000-0001-7109-943X], McGovern, Sophie [0000-0002-6198-7553], Mosuro, Anjola [0000-0002-9013-9289], Moxley, Adam [0000-0001-9794-091X], Mustoe, Sophie [0000-0002-7870-1320], Myers, Sam [0000-0001-6050-4663], Nadeem, Kiran [0000-0001-5988-6780], Newman, Tom [0000-0002-7987-9948], Nzewi, Richard [0000-0002-8159-1302], Ogborne, Rosalie [0000-0003-3327-6030], Omatseye, Joyce [0000-0001-7472-4712], Parkin, James [0000-0002-1861-0822], Patel, Mohit [0000-0003-1168-2759], Pawar, Sohini [0000-0003-0224-5258], Pearce, Stuart [0000-0002-7482-0752], Penrice, Samuel [0000-0002-1142-6686], Ramjan, Raisa [0000-0002-2020-2123], Randhawa, Ratan [0000-0002-4749-4410], Rasul, Usman [0000-0001-5820-1313], Raymond-Taggert, Elliot [0000-0003-1514-6662], Razey, Rebecca [0000-0003-1971-3580], Razzaghi, Carmel [0000-0002-3264-8528], Revell, Elliot John [0000-0001-6025-094X], Rigbye, Joanna [0000-0003-4860-4084], Rotimi, Oloruntobi [0000-0002-1385-1993], Said, Abdelrahman [0000-0002-9801-4202], Sangal, Pranoy [0000-0001-5775-5859], Grandal, Nora Sangvik [0000-0002-2461-7852], Shah, Aadam [0000-0003-1841-5530], Shah, Rahul Atul [0000-0002-6981-7305], Shotton, Oliver [0000-0001-6684-3308], Sims, Daniel [0000-0002-6916-3719], Smith, Martha Amy [0000-0002-4652-3507], Smith, Nick [0000-0003-4478-2772], South, Matthew [0000-0003-2297-1089], Speller, Jessica [0000-0001-5503-4791], Ta, Ngan Hong [0000-0002-8747-5329], Tadross, Daniel [0000-0002-3593-0182], Thompson, Benjamin [0000-0002-2491-5235], Trevett, Jess [0000-0001-5008-1724], Ullah, Roshan [0000-0002-5140-6655], Utukuri, Mrudula [0000-0003-1510-469X], Vadera, Shree [0000-0001-9492-7541], Van Den Tooren, Harriet [0000-0001-9902-7147], Venturini, Sara [0000-0002-9541-0090], Vijayakumar, Aradhya [0000-0002-8702-1087], Vine, Melanie [0000-0002-7978-4375], Wittner, Liora [0000-0003-1271-4839], Yong, Geoffrey Hong Kiat [0000-0003-0103-5793], Ziyada, Farris [0000-0003-2117-7262], Devine, Oliver Patrick [0000-0001-7621-9699], Apollo - University of Cambridge Repository, McManus, IC [0000-0003-3510-4814], and Smith, Daniel T [0000-0003-1215-5811]

Subjects
Male, Students, Medical, 020205 medical informatics, Preparedness, Problem-based learning, media_common.quotation_subject, education, Specialty, lcsh:Medicine, 02 engineering and technology, National Training Study, National Student Survey, 03 medical and health sciences, Patient safety, 0302 clinical medicine, Obstetrics and gynaecology, Perception, 0202 electrical engineering, electronic engineering, information engineering, Medicine, Sanctions, Humans, Quality (business), 030212 general & internal medicine, Fitness to practise, Schools, Medical, GMC sanctions, media_common, Medical education, Postgraduate qualifications, business.industry, lcsh:R, Institutional histories, General Medicine, United Kingdom, Female, Medical school differences, business, Teaching styles, Research Article
Abstract

BackgroundMedical schools differ, particularly in their teaching, but it is unclear whether such differences matter, although influential claims are often made. The Medical School Differences (MedDifs) study brings together a wide range of measures of UK medical schools, including postgraduate performance, fitness to practise issues, specialty choice, preparedness, satisfaction, teaching styles, entry criteria and institutional factors.MethodAggregated data were collected for 50 measures across 29 UK medical schools. Data includeinstitutional history(e.g. rate of production of hospital and GP specialists in the past),curricular influences(e.g. PBL schools, spend per student, staff-student ratio), selection measures(e.g. entry grades),teaching and assessment(e.g. traditional vs PBL, specialty teaching, self-regulated learning), student satisfaction, Foundation selection scores,Foundation satisfaction,postgraduate examination performance andfitness to practise(postgraduate progression, GMC sanctions). Six specialties (General Practice, Psychiatry, Anaesthetics, Obstetrics and Gynaecology, Internal Medicine, Surgery) were examined in more detail.ResultsMedical school differences are stable across time (median alpha = 0.835). The 50 measures were highly correlated, 395 (32.2%) of 1225 correlations being significant withp p Problem-based learning (PBL) schools differ on many measures, including lower performance on postgraduate assessments. While these are in part explained by lower entry grades, a surprising finding is that schools such as PBL schools which reportedgreaterstudent satisfaction with feedback also showedlowerperformance at postgraduate examinations.More medical school teaching of psychiatry, surgery and anaesthetics did not result in more specialist trainees. Schools that taught more general practice did have more graduates entering GP training, but those graduates performed less well in MRCGP examinations, the negative correlation resulting from numbers of GP trainees and exam outcomes being affected both by non-traditional teaching and by greater historical production of GPs.Postgraduate exam outcomes were also higher in schools with more self-regulated learning, but lower in larger medical schools.A path model for 29 measures found a complex causal nexus, most measures causing or being caused by other measures. Postgraduate exam performance was influenced by earlier attainment, at entry to Foundation and entry to medical school (the so-called academic backbone), and by self-regulated learning.Foundation measures of satisfaction, including preparedness, had no subsequent influence on outcomes. Fitness to practise issues were more frequent in schools producing more male graduates and more GPs.ConclusionsMedical schools differ in large numbers of ways that are causally interconnected. Differences between schools in postgraduate examination performance, training problems and GMC sanctions have important implications for the quality of patient care and patient safety.

Published
2020

17. The Analysis of Teaching of Medical Schools (AToMS) survey: an analysis of 47,258 timetabled teaching events in 25 UK medical schools relating to timing, duration, teaching formats, teaching content, and problem-based learning

Author

Anjola Mosuro, Liora Wittner, Reza Nasseri, Zoe Carrington, Emma L Howard, Ifrah Hussain, Ben Phillips, Asanish Kalyanasundaram, Nadine Abbas, Robert Spencer, Keshni Gudka, Zoe Wellbelove, Harriet Hunter, Richard Clough, Alex Eyre, Ahmed Ashraf, Nick Smith, Tobin Joseph, Benjamin Human, Sajan Khullar, Oloruntobi Rotimi, Abdul-Muiz Azri Yahaya, Shreya Badhrinarayanan, Whitney General, Martha Amy Smith, Adele Heaney, Ratan Randhawa, Tom Joseph Syer, Aninditya Salma Sopian, Christina Hood, Katie Smart, Richard Thomas Jackson-Taylor, Jia Jun Ang, Angelos Mantelakis, Shaunak Chatterjee, Bronwen Jacob-Ramsdale, Matthew Tyler, Saba Houshangi, Charlotte Boreham, Wassim Merzougui, Oliver P. Devine, Soham Bandyopadhyay, Tess Marshall-Andon, Liam Curry, Elliot John Revell, Andrew Christopher Harborne, Oliver Shotton, Natasha Benons, Samuel C. Barnes, Sophie McGovern, Daniel Sims, Stuart Pearce, Sami Hussain, Hassan Baig, Catherine Arthur, Tom Newman, Kerry Long, Farris Ziyada, Savraj Kalsi, Agnieszka Jakubowska, Julian Purdy, Rebecca Braine, Julius Elisabeth Richard Lenaerts, Eimear Reel, Joshua William Kearsley, Ross McAllister, Jess Trevett, Jessica Speller, Joseph Beecham, Roshan Ullah, Geoffrey Hong Kiat Yong, Mrudula Utukuri, Sophie Mustoe, Aradhya Vijayakumar, Mohit Patel, Sadhana Kalidindi, Mark Awad, Hugo Layard Horsfall, Ryan Samuels, Eve Lancaster, Carmel Razzaghi, Sonam Aojula, Priscilla Kirkland, Sophie Paddock, Elliot Raymond-Taggert, Omar Risk, Vinay Mandagere, Saleh Jawad, Rebecca Davis, Ngan Hong Ta, Abdelrahman Said, Aadam Shah, Othman Khaled Al-Othman, Usman Rasul, Mehar Chawla, Ryan Janjuha, Wing Hang Serene Ho, I. C. McManus, Sara Venturini, Thomas Hughes-Gooding, Alimatu-Sadia Akeredolu, Verity Ford, Charlie Caird, Aamna Ali, Saad Majeed, Jack Eldridge, Rachel Maguire, Prabhjot Singh Malhotra, Lady-Namera Ejamike, Sarah Freeston, Katherine Aiken, Mike Jones, Oluseyi Adesalu, Shree Vadera, Roxanne Tajbakhsh, Nasreen Desai, Daniel Tadross, Jessica Coulthurst, Vinnie Christine Daniels, Sam Myers, Joseph Brandreth, Chris Clements, Chung Shen Chean, Chris Harlow, Praveen Mahendran, Benjamin Thompson, Adam Moxley, Thomas P. W. Cope, James Druce, Matthew South, Emma Aspinall, Pranoy Sangal, Ammar Ahmed, Ciaran Grafton-Clarke, Daisy Bassey-Duke, Samuel Penrice, Nora Sangvik Grandal, Eleanor Houghton, Amy Harrington, Simon Lubbock, Leher Gumber, Sohini Pawar, Raisa Ramjan, Qaisar Khan, David Johnston, Aisha Sooltangos, Hannah Douglas, Meron Esere, Lucy Holloway, Alena Ashby, Simon Davies, Sophia Fitzgerald-Smith, Hanelie De Waal, Ibrahim T. Fazmin, Rosalie Ogborne, Sahaj Kaur, Melanie Vine, Muzzamil Jelani, Anna Kane, James Coultas, Ibrahim Alam, Jamie Mac Donald Burrell, Hannah Lawrence-Smith, Zoe Cashin, Joyce Omatseye, Sarah Douglas, Helen Gilbert, Harriet Van Den Tooren, Katherine Garnett, Joanna Rigbye, Rebecca Razey, James Parkin, Simon Phillips, Charlotte Leeson, Rahul Atul Shah, Richard Nzewi, Luke Debenham, Zein Gowie, Calum MacMillan, Kiran Nadeem, Fady Sameh Anis, Adam Sage, Emma Sanders, Oliver Jones, Ivan Aganin, Richard B. Anderson, Rishi K Gupta, Ryan Clark, Devine, Oliver Patrick [0000-0001-7621-9699], Harborne, Andrew Christopher [0000-0003-0937-1492], Horsfall, Hugo Layard [0000-0001-7848-5325], Joseph, Tobin [0000-0002-9283-9895], Marshall-Andon, Tess [0000-0001-8909-1639], Samuels, Ryan [0000-0002-0886-7990], Abbas, Nadine [0000-0002-9116-2915], Baig, Hassan [0000-0001-8999-0474], Beecham, Joseph [0000-0002-4390-9164], Benons, Natasha [0000-0002-0750-6560], Caird, Charlie [0000-0001-7553-5585], Clark, Ryan [0000-0002-6143-9098], Cope, Thomas [0000-0003-0247-7411], Coultas, James [0000-0003-3381-8936], Debenham, Luke [0000-0002-3300-7802], Douglas, Sarah [0000-0003-3272-8154], Eldridge, Jack [0000-0001-6792-7714], Hughes-Gooding, Thomas [0000-0001-8483-5686], Jakubowska, Agnieszka [0000-0003-3153-8666], Jones, Oliver [0000-0003-4334-3567], Lancaster, Eve [0000-0001-5703-252X], MacMillan, Calum [0000-0002-8167-0051], McAllister, Ross [0000-0003-1686-1174], Merzougui, Wassim [0000-0001-7398-0095], Phillips, Ben [0000-0002-0489-6700], Risk, Omar [0000-0002-9226-9263], Sage, Adam [0000-0002-7763-404X], Sooltangos, Aisha [0000-0001-5675-1709], Spencer, Robert [0000-0001-9045-6260], Tajbakhsh, Roxanne [0000-0002-3753-6306], Adesalu, Oluseyi [0000-0001-8796-2701], Aganin, Ivan [0000-0002-3711-9430], Aiken, Katherine [0000-0002-3245-7772], Alam, Ibrahim [0000-0003-2853-623X], Ali, Aamna [0000-0003-1255-6113], Anderson, Richard [0000-0003-4734-0208], Anis, Fady Sameh [0000-0002-0950-3777], Arthur, Catherine [0000-0001-9551-6250], Ashraf, Ahmed [0000-0002-3921-8395], Aspinall, Emma [0000-0001-8307-1661], Awad, Mark [0000-0002-6570-010X], Yahaya, Abdul-Muiz Azri [0000-0002-7846-9322], Badhrinarayanan, Shreya [0000-0002-7159-098X], Bandyopadhyay, Soham [0000-0001-6553-3842], Barnes, Sam [0000-0001-6009-406X], Bassey-Duke, Daisy [0000-0002-0408-1042], Boreham, Charlotte [0000-0003-4828-0542], Braine, Rebecca [0000-0003-2751-3378], Brandreth, Joseph [0000-0002-6137-5928], Carrington, Zoe [0000-0002-0006-8334], Chawla, Mehar [0000-0003-0697-815X], Chean, Chung Shen [0000-0002-1625-4078], Clements, Chris [0000-0002-2567-5536], Clough, Richard [0000-0001-6941-7881], Coulthurst, Jessica [0000-0003-0714-9572], Curry, Liam [0000-0002-6906-5502], Daniels, Vinnie Christine [0000-0001-9461-8431], Davies, Simon [0000-0001-5556-7512], Davis, Rebecca [0000-0002-6960-5580], De Waal, Hanelie [0000-0002-9131-9521], Desai, Nasreen [0000-0003-4601-9084], Douglas, Hannah [0000-0001-8113-5465], Druce, James [0000-0001-6849-8560], Ejamike, Lady-Namera [0000-0001-6196-5584], Esere, Meron [0000-0002-1838-0756], Eyre, Alex [0000-0002-0474-5662], Fazmin, Ibrahim Talal [0000-0002-3300-6279], Ford, Verity [0000-0002-1364-8522], Freeston, Sarah [0000-0001-8768-5513], Garnett, Katherine [0000-0003-1135-6478], General, Whitney [0000-0002-9222-4233], Gilbert, Helen [0000-0002-5588-411X], Gowie, Zein [0000-0002-7597-7508], Grafton-Clarke, Ciaran [0000-0002-8537-0806], Gudka, Keshni [0000-0003-0880-6992], Gumber, Leher [0000-0003-0154-1207], Gupta, Rishi [0000-0003-3839-7982], Harlow, Chris [0000-0003-2912-0594], Heaney, Adele [0000-0002-0905-4342], Ho, Wing Hang Serene [0000-0002-2687-3198], Hood, Christina [0000-0001-6821-6324], Howard, Emma [0000-0001-8411-5734], Human, Benjamin [0000-0003-4445-0639], Hunter, Harriet [0000-0002-5204-2371], Hussain, Sami [0000-0002-8654-3617], Jackson-Taylor, Richard Thomas [0000-0002-6949-2977], Jacob-Ramsdale, Bronwen [0000-0001-6215-808X], Jawad, Saleh [0000-0001-8221-9871], Jelani, Muzzamil [0000-0003-3785-415X], Johnston, David [0000-0002-7078-7510], Kalidindi, Sadhana [0000-0002-4274-2913], Kalsi, Savraj [0000-0001-9103-5089], Kalyanasundaram, Asanish [0000-0003-4175-5998], Kane, Anna [0000-0002-6197-2511], Kaur, Sahaj [0000-0002-3446-6082], Al-Othman, Othman Khaled [0000-0001-5930-8593], Khan, Qaisar [0000-0002-5486-4205], Khullar, Sajan [0000-0001-6426-2892], Kirkland, Priscilla [0000-0003-2452-4207], Leeson, Charlotte [0000-0003-4735-2452], Lenaerts, Julius Elisabeth Richard [0000-0002-1626-7792], Long, Kerry [0000-0003-4546-5509], Burrell, Jamie Mac Donald [0000-0002-8175-3973], Maguire, Rachel [0000-0003-4855-5550], Mahendran, Praveen [0000-0002-4084-5222], Majeed, Saad [0000-0003-4289-5597], Malhotra, Prabhjot Singh [0000-0001-7463-3941], Mandagere, Vinay [0000-0002-2969-6457], Mantelakis, Angelos [0000-0001-7109-943X], McGovern, Sophie [0000-0002-6198-7553], Mosuro, Anjola [0000-0002-9013-9289], Moxley, Adam [0000-0001-9794-091X], Mustoe, Sophie [0000-0002-7870-1320], Myers, Sam [0000-0001-6050-4663], Nadeem, Kiran [0000-0001-5988-6780], Newman, Tom [0000-0002-7987-9948], Nzewi, Richard [0000-0002-8159-1302], Ogborne, Rosalie [0000-0003-3327-6030], Omatseye, Joyce [0000-0001-7472-4712], Parkin, James [0000-0002-1861-0822], Patel, Mohit [0000-0003-1168-2759], Pawar, Sohini [0000-0003-0224-5258], Pearce, Stuart [0000-0002-7482-0752], Penrice, Samuel [0000-0002-1142-6686], Ramjan, Raisa [0000-0002-2020-2123], Randhawa, Ratan [0000-0002-4749-4410], Rasul, Usman [0000-0001-5820-1313], Raymond-Taggert, Elliot [0000-0003-1514-6662], Razey, Rebecca [0000-0003-1971-3580], Razzaghi, Carmel [0000-0002-3264-8528], Revell, Elliot John [0000-0001-6025-094X], Rigbye, Joanna [0000-0003-4860-4084], Rotimi, Oloruntobi [0000-0002-1385-1993], Said, Abdelrahman [0000-0002-9801-4202], Sangal, Pranoy [0000-0001-5775-5859], Grandal, Nora Sangvik [0000-0002-2461-7852], Shah, Aadam [0000-0003-1841-5530], Shah, Rahul Atul [0000-0002-6981-7305], Shotton, Oliver [0000-0001-6684-3308], Sims, Daniel [0000-0002-6916-3719], Smith, Martha Amy [0000-0002-4652-3507], Smith, Nick [0000-0003-4478-2772], South, Matthew [0000-0003-2297-1089], Speller, Jessica [0000-0001-5503-4791], Ta, Ngan Hong [0000-0002-8747-5329], Tadross, Daniel [0000-0002-3593-0182], Thompson, Benjamin [0000-0002-2491-5235], Trevett, Jess [0000-0001-5008-1724], Ullah, Roshan [0000-0002-5140-6655], Utukuri, Mrudula [0000-0003-1510-469X], Vadera, Shree [0000-0001-9492-7541], Van Den Tooren, Harriet [0000-0001-9902-7147], Venturini, Sara [0000-0002-9541-0090], Vijayakumar, Aradhya [0000-0002-8702-1087], Vine, Melanie [0000-0002-7978-4375], Wittner, Liora [0000-0003-1271-4839], Yong, Geoffrey Hong Kiat [0000-0003-0103-5793], Ziyada, Farris [0000-0003-2117-7262], McManus, IC [0000-0003-3510-4814], Apollo - University of Cambridge Repository, and McManus, I. C. [0000-0003-3510-4814]

Subjects
Male, 020205 medical informatics, Problem-based learning, lcsh:Medicine, Timetables, Tutorials, 02 engineering and technology, 03 medical and health sciences, Self-regulated learning, 0302 clinical medicine, Clinical teaching, Surveys and Questionnaires, Curriculum mapping, 0202 electrical engineering, electronic engineering, information engineering, Medicine, Humans, 030212 general & internal medicine, Duration (project management), Student perceptions, Medical education, Academic year, business.industry, lcsh:R, General Medicine, United Kingdom, Lectures, Female, Curriculum, Medical school differences, business, Postgraduate training, Teaching styles, Education, Medical, Undergraduate, Research Article
Abstract

Background: \ud What subjects UK medical schools teach, what ways they teach subjects, and how much they teach those subjects is unclear. Whether teaching differences matter is a separate, important question. This study provides a detailed picture of timetabled undergraduate teaching activity at 25 UK medical schools, particularly in relation to problem-based learning (PBL).\ud \ud Method: \ud The Analysis of Teaching of Medical Schools (AToMS) survey used detailed timetables provided by 25 schools with standard 5-year courses. Timetabled teaching events were coded in terms of course year, duration, teaching format, and teaching content. Ten schools used PBL. Teaching times from timetables were validated against two other studies that had assessed GP teaching and lecture, seminar, and tutorial times.\ud \ud Results: \ud A total of 47,258 timetabled teaching events in the academic year 2014/2015 were analysed, including SSCs (student-selected components) and elective studies. A typical UK medical student receives 3960 timetabled hours of teaching during their 5-year course. There was a clear difference between the initial 2 years which mostly contained basic medical science content and the later 3 years which mostly consisted of clinical teaching, although some clinical teaching occurs in the first 2 years. Medical schools differed in duration, format, and content of teaching. Two main factors underlay most of the variation between schools, Traditional vs PBL teaching and Structured vs Unstructured teaching. A curriculum map comparing medical schools was constructed using those factors. PBL schools differed on a number of measures, having more PBL teaching time, fewer lectures, more GP teaching, less surgery, less formal teaching of basic science, and more sessions with unspecified content.\ud \ud Discussion: \ud UK medical schools differ in both format and content of teaching. PBL and non-PBL schools clearly differ, albeit with substantial variation within groups, and overlap in the middle. The important question of whether differences in teaching matter in terms of outcomes is analysed in a companion study (MedDifs) which examines how teaching differences relate to university infrastructure, entry requirements, student perceptions, and outcomes in Foundation Programme and postgraduate training.

Published
2019

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