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13 results on '"Curran, M.E."'

1. Coassembly of K(sub v)LQT1 and minK (IsK) proteins to form cardiac I(sub Ks) potassium channel

Author

Sanguinetti, M.C., Curran, M.E., Zou, A., Shen, J., Spector, P.S., Atkinson, D.L., and Keating, M.T.

Subjects
Potassium channels -- Research, Arrhythmia -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The potassium (K+) channel gene K(sub v)LQT1 coassembles with the 130-amino acid protein minK to form the cardiac I(sub Ks) potassium channel. The minK protein has a single putative transmembrane domain and fails to form functional channels without help of the LQT1 gene. The two delayed-rectifier K+ currents, I(sub Kr) and I(sub Ks) are responsible for the modulation of the action-potential duration in cardiac myocytes. Mutations in the LQT1 gene and dysfunctions of the I(sub Ks) channel leads to cardiac arrhythmias.

Published
1996

2. Genetic analysis of inflammatory bowel disease in a large european patient population supports linkage to human chromosomes 12 and 16

Author

Curran, M.E., primary, Lau, K.F., additional, Cardon, L., additional, Sakul, H., additional, Harris, T.J.R., additional, Hampe, J., additional, Chreiber, S., additional, Stockkers, P., additional, van Deventer, S.J.H., additional, Raedler, A., additional, Kruis, W., additional, Knoflach, P., additional, Wewalka, P., additional, Gionchetti, P., additional, Bridger, S., additional, Macpherson, A.J.S., additional, Mirza, M., additional, Mathew, C., additional, Lee, J., additional, and Jones, J.L., additional

Published
1998
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3. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

Author

Wang, Q., primary, Curran, M.E., additional, Splawski, I., additional, Burn, T.C., additional, Millholland, J.M., additional, VanRaay, T.J., additional, Shen, J., additional, Timothy, K.W., additional, Vincent, G.M., additional, de Jager, T., additional, Schwartz, P.J., additional, Towbin, J.A., additional, Moss, A.J., additional, Atkinson, D.L., additional, Landes, G.M., additional, Connors, T.D., additional, and Keating, M.T., additional

Published
1996
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6. Coassembly of KvLQT1 and minK (IsK) proteins to form cardiac IKs potassium channel.

Author

Sanguinetti, M.C. and Curran, M.E.

Subjects
*POTASSIUM channels, *ARRHYTHMIA
Abstract

Demonstrates that KVLQT1 encodes a K+ channel with biophysical properties unlike other known cardiac currents. The consideration that KvLQT1 might coassemble with another subunit to form functional channels in cardiac myocytes; The coexpression of KvLQT1 with minK inducing a current almost identical with IKs; A possible cause of cardiac arrhythmia.

Published
1996
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8. Genetic analysis of inflammatory bowel disease in a large European cohort supports linkage to chromosomes 12 and 16

Author

Curran^*, M.E., Lau^*, K.F., Hampe^@?, J., Schreiber^@?, S., Bridger^&, S., Macpherson^&, A.J.S., Cardon^*, L.R., Sakul^*, H., Harris^*, T.J.R., Stokkers^@?, P., van Deventer^@?, S.J.H., Mirza^@?, M., Raedler^#, A., Kruis^*^*, W., Meckler^@?^@?, U., Theuer^&^&, D., Herrmann^@?^@?, T., Gionchetti^@?^@?, P., Lee^#^#, J., Mathew^@?, C., and Lennard-Jones^#^#, J.

Abstract

Background & Aims: Inflammatory bowel disease (IBD) is a complex disorder of unknown etiology. Epidemiological investigations suggest a genetic basis for IBD. Recent genetic studies have identified several IBD linkages. The significance of these linkages will be determined by studies in large patient collections. The aim of this study was to replicate IBD linkages on chromosomes 12 and 16 in a large European cohort. Methods: Three hundred fifty-nine affected sibling pairs from 274 kindreds were genotyped using microsatellite markers spanning chromosomes 12 and 16. Affection status of the sibling pairs was defined as Crohn's disease (CD) or ulcerative colitis (UC). Results: Nonparametric statistical analyses showed linkage for both chromosomes. Two-point results for chromosome 12 peaked at D12S303 (logarithm of odds [LOD], 2.15; P = 0.003) for CD and at D12S75 (LOD, 0.92; P = 0.03) for UC. Multipoint analyses produced a peak LOD of 1.8 for CD. Chromosome 16 showed linkage for CD at marker D16S415 (LOD, 1.52; P = 0.007). Multi-point support peaked above markers D16S409 and D16S411 (LOD, 1.7). Conclusions: These data are consistent with linkage of IBD to chromosomes 12 and 16. The replication of genetic risk loci in a large independent family collection indicates important and common susceptibility genes in these regions and will facilitate identification of genes involved in IBD. GASTROENTEROLOGY 1998;115:1066-1071

Published
1998
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9. Dress, Evening

Author

M.E. Curran & M.E. Clancy, American, M.E. Curran & M.E. Clancy, and American

Abstract

front; Stamped in petersham: "M.E. Curran & M.E. Clancy/25. West 22nd Street. 25/New-York", Please note that if this image is under copyright, you may need to contact one or more copyright owners for any use that is not permitted under the ARTstor Terms and Conditions of Use or not otherwise permitted by law. While ARTstor tries to update contact information, it cannot guarantee that such information is always accurate. Determining whether those permissions are necessary, and obtaining such permissions, is your sole responsibility.

10. Dress, Evening

Author

M.E. Curran & M.E. Clancy, American, M.E. Curran & M.E. Clancy, and American

Abstract

detail; Stamped in petersham: "M.E. Curran & M.E. Clancy/25. West 22nd Street. 25/New-York", Please note that if this image is under copyright, you may need to contact one or more copyright owners for any use that is not permitted under the ARTstor Terms and Conditions of Use or not otherwise permitted by law. While ARTstor tries to update contact information, it cannot guarantee that such information is always accurate. Determining whether those permissions are necessary, and obtaining such permissions, is your sole responsibility.

11. Dress, Evening

Author

M.E. Curran & M.E. Clancy, American, M.E. Curran & M.E. Clancy, and American

Abstract

side; Stamped in petersham: "M.E. Curran & M.E. Clancy/25. West 22nd Street. 25/New-York", Please note that if this image is under copyright, you may need to contact one or more copyright owners for any use that is not permitted under the ARTstor Terms and Conditions of Use or not otherwise permitted by law. While ARTstor tries to update contact information, it cannot guarantee that such information is always accurate. Determining whether those permissions are necessary, and obtaining such permissions, is your sole responsibility.

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