130 results on '"Curi, P. R."'
Search Results
2. Interrelationships of zinc with glucose and insulin metabolism in humans
- Author
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Brandão-Neto, J., Vieira, J. G. H., Shuhama, T., Russo, E. M. K., Piesco, R. V., and Curi, P. R.
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- 1990
- Full Text
- View/download PDF
3. Paracoccidioidomycosis: A comparative study of the evolutionary serologic, clinical and radiologic results for patients treated with ketoconazole or amphotericin B plus sulfonamides
- Author
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Marques, S. A., Dillon, N. L., Franco, M. F., Habermann, M. C., Lastoria, J. C., Stolf, H. O., Marcondes, J., Grizzo, W., Silva, N. C. A., Cavariani, M. R., and Curi, P. R.
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- 1985
- Full Text
- View/download PDF
4. Use of anaerobic cecal microflora, lactose and acetic acid for the protection of broiler chicks against experimental infection with Salmonella Typhimurium and Salmonella Enteritidis
- Author
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Andreatti, R. L., Silva, E. N. da, Ribeiro, A. R., Kondo, N., Curi, P. R., Universidade Estadual Paulista (Unesp), and Universidade Estadual de Campinas (UNICAMP)
- Subjects
lactose ,S. Enteritidis ,acetic acid ,Salmonella Typhimurium ,competitive exclusion ,broiler chicks ,anaerobic cecal microflora - Abstract
Made available in DSpace on 2020-12-10T18:00:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2000-04-01 The effects of treatment with anaerobic cecal microflora (ACM) and/or lactose and/or acetic acid on systemic and digestive tract of broiler chicks infection with Salmonella Typhimurium and S. Enteritidis were studied. ACM was used without previous bacterial identification. Treatment with ACM contributed to the resistance of broiler chicks to infection with Salmonella spp. The infections were mon persistent in the cecum, rectum and crops in decreasing order of intensity. The infections were also self-limiting since treated and control lots presented similar infection rates at the end of the experiments. Alone or in combination with lactose, ACM reduced the colonization of the digestive tract of broiler chicks by S. Typhimurium and S. Enteritidis. The effect of the combination of ACM with lactose or acetic acid was not potentiated in terms of reduction of fecal excretion of Salmonella spp. Treatment with ACM reduced the amount of S. Typhimurium and S. Enteritidis in the feces. Alone or in combination with lactose, ACM reduced the cecal pH in treated birds. S. Enteritidis was much more invasive than S. Typhimurium and the use of ACM alone was more effective on the reduction of systemic infection. An explanation for the process of prevention of intestinal colonization with Salmonella spp. probably resides in the interrelationship of physiological, microbiological and immunological phenomena, as well as the variation in cecal pH. UNESP, Fac Med Vet & Zootecnia, Dept Clin Vet, BR-18618000 Botucatu, SP, Brazil UNESP, Fac Med Vet & Zootecnia, Dept Melhoramento & Nutr Anim, BR-18618000 Botucatu, SP, Brazil Univ Estadual Campinas, Fac Engn Alimentos, Dept Tecnol Alimentos, Campinas, SP, Brazil UNESP, Fac Med Vet & Zootecnia, Dept Clin Vet, BR-18618000 Botucatu, SP, Brazil UNESP, Fac Med Vet & Zootecnia, Dept Melhoramento & Nutr Anim, BR-18618000 Botucatu, SP, Brazil
- Published
- 2000
5. Blood constituents of lactating, weaned and adult Nelore cattle (Bos indicus), and Holstein cattle (Bos taurus), and Murrah buffalo (Bubalus bubalis)
- Author
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Fagliari, J. J., Santana, A. E., Lucas, F. A., Campos, E., Curi, P. R., Universidade Estadual Paulista (UNESP), and Universidade Estadual Paulista (Unesp)
- Subjects
Blood constituent ,Buffalo ,Cattle - Abstract
Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2014-02-26T17:18:29Z No. of bitstreams: 1 WOS000076517000005.pdf: 5211128 bytes, checksum: b9d54f315239f19ca0f23fe10f0cdfb7 (MD5) Made available in DSpace on 2014-02-26T17:18:29Z (GMT). No. of bitstreams: 1 WOS000076517000005.pdf: 5211128 bytes, checksum: b9d54f315239f19ca0f23fe10f0cdfb7 (MD5) Previous issue date: 1998-06-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:28:27Z No. of bitstreams: 1 WOS000076517000005.pdf: 5211128 bytes, checksum: b9d54f315239f19ca0f23fe10f0cdfb7 (MD5) Made available in DSpace on 2014-05-20T15:28:27Z (GMT). No. of bitstreams: 1 WOS000076517000005.pdf: 5211128 bytes, checksum: b9d54f315239f19ca0f23fe10f0cdfb7 (MD5) Previous issue date: 1998-06-01 Blood samples from lactating, weaned and adult Holstein-Fresiean and Nelore cattle and Murrah buffaloes were tested through the study of hemogram and serum constituents. Red cell and leukocyte counts, and blood pH, fibrinogen, glucose, calcium, and phosphorus levels were similar in cattle and buffalo. Total protein, urea, creatinine, hemoglobin, magnesium, iron and aspartato aminotransferase and alanine aminotransferase activities were higher in buffalo than cattle. Leukocyte counts were higher for weaned Holstein cattle than for Nelore cattle but similar to buffalo and Nelore cattle had the lowest neutrophil counts. Bilirrubin levels were lower for buffalo than for cattle. Phosphatase alkalyne activities were lower for weaned buffalo than for other animals. Gammaglutamyltransferase activities were the highest for lactating and weaned buffalo. UNESP, Fac Ciências Agrarias & Vet, BR-14870000 Jaboticabal, SP, Brazil UNESP, FCAV, Jaboticabal, SP, Brazil UNESP, FMVZ, Botucatu, SP, Brazil UNESP, Fac Ciências Agrarias & Vet, BR-14870000 Jaboticabal, SP, Brazil UNESP, FCAV, Jaboticabal, SP, Brazil UNESP, FMVZ, Botucatu, SP, Brazil
- Published
- 1998
6. Blood constituents of Nelore cattle (Bos indicus), Holstein cattle (Bos taurus) and Murrah buffalo (Bubalus bubalis) cows during pregnancy, at the time of calving and at post-partum
- Author
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Fagliari, J. J. [UNESP], Santana, A. E. [UNESP], Marchió, W., Campos Filho, E. [UNESP], Curi, P. R. [UNESP], Universidade Estadual Paulista (Unesp), and Universidade Estadual Paulista (UNESP)
- Subjects
buffalo ,cattle ,pregnancy ,blood constituents ,calving - Abstract
Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2014-02-26T17:18:30Z No. of bitstreams: 1 WOS000076517000006.pdf: 4642944 bytes, checksum: 372e1fea64f4e20739d7b3d48431d694 (MD5) Made available in DSpace on 2014-02-26T17:18:30Z (GMT). No. of bitstreams: 1 WOS000076517000006.pdf: 4642944 bytes, checksum: 372e1fea64f4e20739d7b3d48431d694 (MD5) Previous issue date: 1998-06-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:25:46Z No. of bitstreams: 1 WOS000076517000006.pdf: 4642944 bytes, checksum: 372e1fea64f4e20739d7b3d48431d694 (MD5) Made available in DSpace on 2014-05-20T15:25:46Z (GMT). No. of bitstreams: 1 WOS000076517000006.pdf: 4642944 bytes, checksum: 372e1fea64f4e20739d7b3d48431d694 (MD5) Previous issue date: 1998-06-01 Blood constituents of Nelore, Hosltein and buffalo cows were determined during pregnancy, at the time of calving and at post-partum. It was verified that. 1. The pregnancy and post-partum periods had no influence in the erythrocyte values, but at calving the red blood cell counts and hemoglobin levels of Holstein and buffalo cows were lower than for Nelore cattle; 2. leukocyte counts were similar among groups; 3. total protein levels of Nelore cows were lower than Holstein and buffalo. The albumin levels were rite lowest at rite time of calving compared to late pregnancy; 4. glicose levels were lower ill buffalo cows during pregnancy as compared with Holstein cows. The glicemia of Nelore cows was lower as compared to Holstein cow's irt late pregnancy; 5. urea and creatinine levels were higher in buffalo cows than cattle. The urea and creatinine levels were greater in buffalo cows with maximum values at the post-partum and at the parturition, respectively; 6. bilirrubin levels were higher in bovine than buffalo cows; 7. aspartate aminotransferase activity was greater in buffalo cows and increased at the time of calving; 8. alkaline phosphatase activity was increased during pregnancy and decreased after the time of calving; 9. gammnglutamyltransferase activity,vas the highest for buffalo cows after calving; IO. calcium levels were the highest for Holstein cows at the post-partum and the phosphorus levels were higher in buffalo cows, which had the highest magnesium levels at the parturation. UNESP, Fac Cienicias Agrarias & Vet, BR-14870000 Jaboticabal, SP, Brazil UNESP, FMVZ, Botucatu, SP, Brazil UNESP, Fac Cienicias Agrarias & Vet, BR-14870000 Jaboticabal, SP, Brazil UNESP, FMVZ, Botucatu, SP, Brazil
- Published
- 1998
7. Blood constituents of the newborn Nelore cattle (Bos indicus), Holstein cattle (Bos taurus), and Murrah buffalo (Bubalus bubalis)
- Author
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Fagliari, J. J. [UNESP], Santana, A. B. [UNESP], Lucas, F. A. [UNESP], Campos Filho, E. [UNESP], Curi, P. R. [UNESP], Universidade Estadual Paulista (Unesp), and Universidade Estadual Paulista (UNESP)
- Subjects
buffalo ,cattle ,newborn ,blood constituents - Abstract
Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2014-02-26T17:18:27Z No. of bitstreams: 1 WOS000076517000004.pdf: 4833228 bytes, checksum: 5ecdfd16dacb43e01488fae67ea8156c (MD5) Made available in DSpace on 2014-02-26T17:18:27Z (GMT). No. of bitstreams: 1 WOS000076517000004.pdf: 4833228 bytes, checksum: 5ecdfd16dacb43e01488fae67ea8156c (MD5) Previous issue date: 1998-06-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:25:45Z No. of bitstreams: 1 WOS000076517000004.pdf: 4833228 bytes, checksum: 5ecdfd16dacb43e01488fae67ea8156c (MD5) Made available in DSpace on 2014-05-20T15:25:45Z (GMT). No. of bitstreams: 1 WOS000076517000004.pdf: 4833228 bytes, checksum: 5ecdfd16dacb43e01488fae67ea8156c (MD5) Previous issue date: 1998-06-01 Newborn Holstein-Friesian and Nelore cattle and Murrah buffalo blood samples were collected for hemograma and serum constituents testing. Results indicated that: 1. buffalo red blood cell (RBC) counts were lower than RBC counts for cattle during the first 30 days after birth; 2. buffalo leukocytes, neutrophil and lymphocyte counts increased in older animals; 3. The highest fibrinogen levels occurred in older calves; 4. buffalo glucose levels were lower than Nelore cattle and decreased in the older calves; 5. buffalo iron, urea, and aspartate aminotransferase levels were higher than in cattle with the highest concentration at the time of birth; 6. cattle bilirubin and alanine aminotranferase levels were higher than buffalo with the highest value at the time of birth; 7. alkaline phosphatase and gammaglutamyltransferase activities were lower in the older calves; 8. buffalo magnesium levels were higher than cattle with lower concentrations at the time of birth.. UNESP, Fac Ciências Agrarias & Vet, BR-14870000 Jaboticabal, SP, Brazil UNESP, FCAVJ, Jaboticabal, SP, Brazil UNESP, FMVZ, Botucatu, SP, Brazil UNESP, Fac Ciências Agrarias & Vet, BR-14870000 Jaboticabal, SP, Brazil UNESP, FCAVJ, Jaboticabal, SP, Brazil UNESP, FMVZ, Botucatu, SP, Brazil
- Published
- 1998
8. Onset time and intubating conditions of rocuronium and succinylcholine
- Author
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Vianna, Pedro Thadeu Galvão [UNESP], Catiglia, Y. M M [UNESP], Ganem, Eliana Marisa [UNESP], Takata, I. H. [UNESP], Braz, José Reinaldo Cerqueira [UNESP], Curi, P. R. [UNESP], and Universidade Estadual Paulista (Unesp)
- Subjects
anesthesia induction ,clinical article ,controlled clinical trial ,side effect ,rocuronium, succinylcholine [Neuromuscular blockers] ,suxamethonium ,rocuronium ,clinical trial ,nerve stimulation ,fentanyl ,neuromuscular blocking ,midazolam ,neuromuscular blocking agent ,randomized controlled trial ,heart rate ,controlled study ,ulnar nerve ,human ,arterial pressure - Abstract
Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:18:16Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:38:54Z : No. of bitstreams: 1 2-s2.0-0030863903.pdf: 62302 bytes, checksum: cb3dcb88acf8896f54dd9243b4b15a0e (MD5) Made available in DSpace on 2014-05-27T11:18:16Z (GMT). No. of bitstreams: 0 Previous issue date: 1997-10-15 Background and Objectives - Pulmonary aspiration of gastric content during induction of anesthesia for emergency surgical procedures is a serious complication; fast endotracheal intubation under these circumstances is of vital importance to secure the airways. Despite its numerous side effects, succinylcholine is used for this purpose. Rocuronium is the most recently introduced aminoesteroid neuromuscular blocking drug with short onset. The objective of this study was to compare the onset time and intubating conditions of rocuronium and succinylcholine. Methods - After informed consent, forty-five patients were randomly allocated into three groups of 15: Group I (GI) = succinylcholine 1 mg.kg-1; Group II (GII) = rocuronium 0.6 mg.kg-1; Group III (GIII) = rocuronium 0.9 mg.kg-1. Every patient was premedicated with midazolam 15 mg per os and induction of anesthesia was made with fentanyl 10 μg.kg-1 and etomidate 0.3 mg.kg-1. The neuromuscular block was monitored with the TOP-Guard neuromuscular transmission monitor. The TOP-Guard neuromuscular monitor uses an accelerometer to measure the response to nerve stimulation. The stimulating electrodes were placed close to the course of the ulnar nerve at the wrist. The onset time was considered as the time between the end of neuromuscular drug injection and the twitch height (T1) decrease to 10%. Heart rate and arterial blood pressure were registered at 6 moments before and after induction of anesthesia. Results - The onset time results were: Group I, 71 s; Group II, 120 s and Group III, 70 s or GI = GIII < GII (F = 8.862; p < 0.01). There were 43 patients exhibiting excellent intubating conditions and 2 with good intubating conditions. Heart rate and arterial blood pressure showed alterations due to induction of anesthesia and intubation. Conclusions - Rocuronium 0.9 mg.kg-1 can be used in rapid sequence induction because it has a short onset time which is similar to that of succnylcholine. It is likely that rocuronium would be a good indication in patients with high intracranial pressure, burns and neuromuscular diseases. UNESP Depto. de Anestesiologia, Rubiao Junior, 18618-970 Botucatu-SP UNESP Depto. de Anestesiologia, Rubiao Junior, 18618-970 Botucatu-SP
- Published
- 1997
9. Comparative susceptibility and pathogeny of Nelore and Holstein-Friesian calves to the experimental infection of Haemonchus placei (Place, 1893)
- Author
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Lopes, Raimundo Souza [UNESP], Bressan, MCRV, Kohayagava, A., Sequeira, Julio Lopes [UNESP], Curi, P. R., and Universidade Estadual Paulista (Unesp)
- Subjects
calf ,Holstein ,Nelore ,Haemonchus placei ,helminth - Abstract
Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2014-02-26T17:08:46Z No. of bitstreams: 1 WOSA1997XU89300002.pdf: 5140955 bytes, checksum: e3de0a1ec4398f43a0f098820ed9046b (MD5) Made available in DSpace on 2014-02-26T17:08:46Z (GMT). No. of bitstreams: 1 WOSA1997XU89300002.pdf: 5140955 bytes, checksum: e3de0a1ec4398f43a0f098820ed9046b (MD5) Previous issue date: 1997-06-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:22:10Z No. of bitstreams: 1 WOSA1997XU89300002.pdf: 5140955 bytes, checksum: e3de0a1ec4398f43a0f098820ed9046b (MD5) Made available in DSpace on 2014-05-20T15:22:10Z (GMT). No. of bitstreams: 1 WOSA1997XU89300002.pdf: 5140955 bytes, checksum: e3de0a1ec4398f43a0f098820ed9046b (MD5) Previous issue date: 1997-06-01 Two groups of Holstein-Friesian and Nelore calves, five animals each, about nine months old, received, by oral route, 1,000 infective larvae (L-3) per kg of body weight of Haemonchus placei. Blood samples were collected by venipuncture, at weekly intervals, from one week before, to eight weeks after infection. Hematological studies comprised the hematocrit, differential leukocyte counts, hemoglobin, fibrinogen and plasma protein determinations. Parasitological examinations covered weekly fecal egg counts (EPG) and worm burden counts at necropsy. Samples of the abomasal mucosa were submitted to gross examination and histopathological studies. Both groups had increasing EPG after the fifth week, with Holstein calves showing higher counts than the Nelore. Holstein calves had anemia and hipoproteinemia from the third week post-infection to the end of the experiment, whereas Nelore calves showed no significant differences in those, parameters. Holstein calves had significantly larger worm counts than the Nelore. The gross and histopathological lesions in the abomasum at necropsy were very similar, although macroscopically they look more apparent in the Holstein group. These results showed that Holstein calves are more susceptible to the infection and pathogenic effects of H. placei than Nelore calves. UNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO,FMVZ,DEPT CLIN VET,CAIXA POSTAL 560,BR-18618000 BOTUCATU,SP,BRAZIL UNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO,FMVZ,DEPT CLIN VET,CAIXA POSTAL 560,BR-18618000 BOTUCATU,SP,BRAZIL
- Published
- 1997
10. Liver dysfunction in patients bitten by Crotalus Durissus terrificus (Laurenti, 1768) snakes in Botucatu (State of São Paulo, Brazil)
- Author
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Barraviera, B. [UNESP], Coelho, K. Y. [UNESP], Curi, P. R. [UNESP], Meira, D. A. [UNESP], and Universidade Estadual Paulista (UNESP)
- Abstract
Made available in DSpace on 2022-04-28T19:54:17Z (GMT). No. of bitstreams: 0 Previous issue date: 1995-01-01 Thirty-two patients bitten by venomous snakes sixteen by Bothrops spp. and sixteen by Crotalus durissus terrificus were studied. The group comprised thirty males and two females, aged eight to sixty-three years (mean 33 +/- 15). Bromsulphalein tests were increased in the majority of patients bitten by Crotalus durissus terrificus. The correlation coefficient of Spearman was positive between bromsulphalein tests and alanine aminotransferase levels, and between alanine aminotransferase and aspartate aminotransferase levels only in the Crotalus group. The only patient who died was bitten by Crotalus durissus terrificus and showed hydropic degeneration and mitochondrial injury in the liver. It was concluded that the hepatic damage might have been caused by at least two possible mechanisms: venom effect on liver mitochondria and cytokine effects on hepatocyte, specially interleukin-6. Departamento de Doenças Tropicais e Diagnóstico por Imagem Faculdade de Medicina de Botucatu - UNESP Departamento de Doenças Tropicais e Diagnóstico por Imagem Faculdade de Medicina de Botucatu - UNESP
- Published
- 1995
11. Effects of continuous infusion of propofol on renal function in the dog. Comparative study with pentobarbital sodium
- Author
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Do Nascimento, C. [UNESP], Braz, José Reinaldo Cerqueira [UNESP], Curi, P. R. [UNESP], Vane, Luiz Antonio [UNESP], Castiglia, Yara Marcondes Machado [UNESP], and Universidade Estadual Paulista (Unesp)
- Subjects
glomerulus filtration rate ,nonhuman ,propofol ,alcuronium ,animal experiment ,blood pressure ,continuous infusion, venous [anesthetic technique, general] ,urine volume ,hemodynamics ,clearance, function [kidney] ,intravenous drug administration ,dog ,heart rate ,blood flow ,propofol, pentobarbital sodium [anesthetic, venous] ,controlled study ,sodium excretion ,kidney function ,pentobarbital ,hemodynamic [monitoring] - Abstract
Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:17:55Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:28:16Z : No. of bitstreams: 1 2-s2.0-0028355925.pdf: 55525 bytes, checksum: 606be18cdf3cfe82315ba7e40cf9e1eb (MD5) Made available in DSpace on 2014-05-27T11:17:55Z (GMT). No. of bitstreams: 0 Previous issue date: 1994-01-01 Little research has been done with propofol in relation to renal function. The aim of this study was to evaluate the effects of the continuous infusion of propofol on renal function in dogs. Sixteen dogs, previously anesthetized with pentobarbital sodium (30 mg.kg-1) for surgical preparation, catheterism and monitoring, were studied. The dogs were mechanically ventilated with air and received alcuronium (0.2 mg.kg-1 in bolus and 0.06 mg.kg-1 - maintenance). The following parameters were studied: heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP), aortic blood flow (A(o)BF - by electromagnetic flowmeter installed in the ascending aortic), aortic vascular resistance index (A(o)VRI), renal plasma flow (ERPF - by para-aminohipurate clearance), glomerular filtration rate (GFR - by creatinine clearance), effective renal blood flow (ERBF = ERPF/1 - hematocrit), urinary volume (UV), renal vascular resistance (RVR = MAP.80/ERBF.10-3), urinary sodium excretion (UE(Na)), fractionated sodium excretion (FE(Na)), osmolar clearance (C(osm)) and free water clearance (C(H2O)). These parameters were studied at 15 (M1), 30 (M2), 45 (M3) and 60 (M4) min after beginning pentobarbital sodium infusion (5 mg.kg-1.h-1). The dogs were allocated into two groups of eight animals each: G1 (control-pentobarbital sodium) and G2 (propofol). In G1, pentobarbital was given at the four times studied. G2 dogs received the same treatment as G1 dogs at M1 and M2; infusion of pentobarbital was substituted by propofol (3 mg.kg-1 bolus, followed by 12 mg.kg-1.h-1 continuous infusion) at M3 and M4. Profile Analysis was used to analyze the results statistically. In G1 (pentobarbital), there was a significant increase in RVR (M1 < M4) and a decrease in ERPF and ERBF (M1 > M4). In G2 (propofol) there was only a significant increase in A(o)BF (M1 < M2 = M3). In comparison among groups, these was a significant alteration of FE(Na) at M3 (pentobarbital > propofol). It was observed that the continuous infusion of propofol in dogs, at the given doses, did not alter the basic variables of renal function and hemodynamics studied. We concluded that propofol can be one of the drugs of choice to provide base anesthesia in studies of renal function in dogs. Departamento de Anestesiologia Faculdado de Medicina UNESP, 18618-000 Rubiao Junior, Botucatu Departamento de Anestesiologia Faculdado de Medicina UNESP, 18618-000 Rubiao Junior, Botucatu
- Published
- 1994
12. MODULATION OF PARASITEMIA AND ANTIBODY-RESPONSE TO TRYPANOSOMA-CRUZI BY CYCLOPHOSPHAMIDE IN CALOMYS-CALLOSUS (RODENTIA, CRICETIDAE)
- Author
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Borges, M. M., Curi, P. R., Kloetzel, J. K., Universidade de São Paulo (USP), and Universidade Estadual Paulista (Unesp)
- Subjects
CALOMYS-CALLOSUS ,MORTALITY ,parasitic diseases ,CYCLOPHOSPHAMIDE ,PARASITEMIA ,ANTIBODY RESPONSE ,TRYPANOSOMA-CRUZI - Abstract
Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2014-02-26T17:04:50Z No. of bitstreams: 0 Made available in DSpace on 2014-02-26T17:04:50Z (GMT). No. of bitstreams: 0 Previous issue date: 1992-01-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:22:30Z No. of bitstreams: 0 Made available in DSpace on 2014-05-20T15:22:30Z (GMT). No. of bitstreams: 0 Previous issue date: 1992-01-01 Calomys callosus a wild rodent, previously described as harboring Trypanosoma cruzi, has a low susceptibility to infection by this protozoan.Experiments were designed to evaluate the contribution of the immune response to the resistance to T. cruzi infection exhibited by C. callosus. Animals were submitted to injections of high (200 mg/kg body weight) and low (20 mg/kg body weight) doses of cyclophosphamide on days -1 or -1 and +5, and inoculated with 4 x 10(3) T. cruzi on day O. Parasitemia, mortality and antibody response as measured by direct agglutination of trypomastigotes were observed. Two hundred mg doses of cyclophosphamide resulted in higher parasitemia and mortality as well as in suppression of the antibody response. A single dose of 20 mg enhanced antibody levels on the 20th day after infection, while an additional dose did not further increase antibody production. Parasitemia levels were not depressed, but rather increased in both these groups as compared to untreated controls. Passive transfer of hyperimmune C. callosus anti-T. cruzi serum to cyclophosphamide immunosuppressed animals resulted in lower parasitemia and mortality rates. These results indicate that the immune response plays an important role in the resistance of C. callosus to T. cruzi. INST MED TROP SAO PAULO,SAO PAULO,BRAZIL UNIV ESTADUAL PAULISTA,INST BASICO BIOL MED & AGR,DEPT STAT,BOTUCATU,SP,BRAZIL UNIV SAO PAULO,INST CIENCIAS BIOMED,DEPT PARASITOL,SAO PAULO,BRAZIL UNIV ESTADUAL PAULISTA,INST BASICO BIOL MED & AGR,DEPT STAT,BOTUCATU,SP,BRAZIL
- Published
- 1992
13. Grupos Sanguineos de Bovinos
- Author
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CAMINHAS, M. M. T., BORTOLOZZI, J., CHAMMA, O. J., and CURI, P. R.
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Pitangueiras ,Gir ,Nelore ,Girolanda ,Pardo-Suico - Abstract
No presente estudo de grupos sanguineos de bovinos da regiao de Botucatu, SP, foram utilizados 148 bovinos puros de origem, mesticos, adultos e de ambos os sexos, das racas Pardo-Suico, Girolanda, Pitangueiras, Gir e Nelore. De cada bovino foram coletados 10 ml de sangue venoso em frascos com anticoagulante. Os grupos sanguineos foram identificados atraves de testes hemoliticos, conforme a tecnica de Stormont, utilizando-se 42 reagentes de tipagem sanguinea, especificos para bovinos. A maioria dos fatores sanguineos presentes com frequencia alta e significativa (P
- Published
- 1992
14. Crescimento Pos-Natal do Coelho Norfolk: Correlacao entre Parametros Somaticos e Area dos Tipos de Fibras Musculares
- Author
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Pai, V. D., Curi, P. R., and Universidade Estadual Paulista (Unesp)
- Subjects
intestinos ,Músculo ,STOMACH ,Ceco ,CARCASS ,INTESTINES ,Peso corporal ,BODY WEIGHT ,MUSCLE ,Carcaça ,CECUM ,Estomago - Abstract
Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2014-02-26T17:05:08Z No. of bitstreams: 0 Made available in DSpace on 2014-02-26T17:05:08Z (GMT). No. of bitstreams: 0 Previous issue date: 1992-12-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:21:00Z No. of bitstreams: 0 Made available in DSpace on 2014-05-20T15:21:00Z (GMT). No. of bitstreams: 0 Previous issue date: 1992-12-01 A área das fibras musculares esqueléticas, o peso corporal, da carcaça, de um músculo, o volume gástrico, o comprimento do ceco e dos intestinos foram avaliados em coelhos Norfolk, do nascimento à 26a semana. Para o estudo da área dos tipos de fibras musculares, segmentos do músculo flexor carpo-radial foram congelados a -70oC. Cortes obtidos em criostato com 8 m de espessura foram corados pela Hematoxilina e Eosina e outros, incubados para as enzimas: SDH, NADH-TR e m-ATPase, após pré-incubação em meio ácido e alcalino. Os dados foram submetidos a testes estatísticos de significância. As variáveis estudadas revelaram acentuada correlação entre si. A razão peso da carcaça/peso corporal atingiu 55,1% na 10a semana. Este valor revelou-se estável até a 22a semana, diminuindo nas idades subseqüentes. No periodo estudado, a área das fibras SO, FOG e FG aumentou 9,1 vezes, 12,4 vezes e 22,2 vezes respectivamente. Na 10a semana, as fibras aeróbicas SO e FOG tenderam a estabilizar seu crescimento, enquanto que as fibras anaeróbicas FG revelaram ativo crescimento. Com a estabilização do crescimento das fibras SO e FOG, o aumento da massa muscular apósa 10a semana parece ocorrer principalmente pela hipertrofia das fibras anaeróbicas FG. Skeletal muscle fibers areas, the weight of body, carcass and muscle, the gastric content and the length of intestines and caecum of Norfolk rabbit from neonate to 26th week were measured. Types of fibers and areas were studied in -70-degrees-C frozen blocks of flexor carpo radialis muscle. Some sections were stained with Haematoxylin and Eosin and others were submitted to SDH, NADH-TR and m-ATPase, followed by acid and alkali preincubations. All parameters revealed a high degree of correlation. Carcass weight/body weight ratio reached 55,1% at 10th week. From neonate to 26th week, the areas of SO, FOG and FG muscle fibers increased of x9.1, x12.4 and x22.2. While SO and FOG fibers tend to stabilize their growth at 10th week, FG fibers were active at this age. Due to early stabilization of SO and FOG fibers growth, the additional increase in muscle tissue in attributed mainly to hypertrophy of FG fibers. UNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO,IB,DEPT MORFOL,BR-18600 BOTUCATU,SP,BRAZIL UNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO,IB,DEPT MORFOL,BR-18600 BOTUCATU,SP,BRAZIL
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- 1992
15. CAPTOPRIL NA HIPERTENSAO ARTERIAL LEVE E MODERADA RESISTENTE A DIURETICOTERAPIA. ESTUDO MULTICENTRICO
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Da Silva Franco, R. J. [UNESP], Curi, P. R. [UNESP], Kohlmann, O. [UNESP], Leite, J. B. [UNESP], Spritzer, N. [UNESP], Lorga, A. M. [UNESP], Salomao, F. A. [UNESP], Ferreira, F. S R [UNESP], Chuster, M. [UNESP], Mion, D. M. [UNESP], Diani, P. A. [UNESP], Simoes, J. D S [UNESP], Bergamo, R. [UNESP], Ribeiro, A. B. [UNESP], and Universidade Estadual Paulista (Unesp)
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Adult ,Male ,clinical article ,hypertension ,Captopril ,Adolescent ,potassium ,drug effect ,oral drug administration ,drug combination ,Drug Resistance ,clinical trial ,Blood Pressure ,English Abstract ,hydrochlorothiazide ,Middle Age ,female ,multicenter study ,blood ,Drug Therapy, Combination ,human ,Aged - Abstract
Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:17:27Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:28:09Z : No. of bitstreams: 1 2-s2.0-0026833448.pdf: 166240 bytes, checksum: 8de5be06de4c886e9ea0c5cdb1dd4efe (MD5) Made available in DSpace on 2014-05-27T11:17:27Z (GMT). No. of bitstreams: 0 Previous issue date: 1992-01-01 Disciplina de Nefrologia Depto. Clinica Medical UNESP, 18610 Botucat Disciplina de Nefrologia Depto. Clinica Medical UNESP, 18610 Botucat
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- 1992
16. Immune reconstitution in HIV-1 infected patients treated for two years with highly active antiretroviral therapy
- Author
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Almeida, R. A. M. B., primary, Souza, L. R., additional, Calvi, S. A., additional, Ikoma, M. R. V., additional, Silva, V. A., additional, Curi, P. R., additional, and Meira, D. A., additional
- Published
- 2006
- Full Text
- View/download PDF
17. Morphological, Histochemical and Morphometric Study of the Myotomal Muscle Tissue of the Pacu (Piaractus mesopotamicus Holmberg 1887: Serrasalminae, Characidae, Teleostei)
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Dal Pai, V., primary, Dal Pai‐Silva, M., additional, Carvalho, E. D., additional, Fujihara, C. Y., additional, Gregório, E. A., additional, and Curi, P. R., additional
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- 2000
- Full Text
- View/download PDF
18. Histochemical Study of the Extensor Digitorum Longus and Soleus Muscles in Alcoholic Rats
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Torrejais, M. M., primary, Soares, J. C., additional, Matheus, S. M. M., additional, Cassel, F. D., additional, and Curi, P. R., additional
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- 1999
- Full Text
- View/download PDF
19. Alcohol levels in cerebrospinal fluid and blood samples from patients under pathological conditions
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Agapejev, S., primary, Vassilieff, I., additional, and Curi, P. R., additional
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- 1992
- Full Text
- View/download PDF
20. Treatment of rat nephrotoxic nephritis. Use of 5-fluorouracil or methotrexate-5-fluorouracil association.
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de Almeida, Dinah B. and Curi, P. R.
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KIDNEY diseases , *FLUOROURACIL , *METHOTREXATE , *IMMUNOFLUORESCENCE , *GLOMERULONEPHRITIS , *PROTEINURIA - Abstract
To evaluate the effect or 5-fluorouracil (F) and methotrexatc-5-fluorouracil association (MTX-F) on nephrotoxic nephritis, seven groups of 10 rats were inoculated with anti-rat glomerular basement membrane serum (AGBMS); five groups were treated with different doses of F, beginning on the 2nd or the 6th day, one group with MTX-F beginning on the 2nd day and one group (control) with distilled water. Twenty-four hour proteinuria was determined weekly until the 71st day. The kidneys were examined histologically and by immunofluorescence. The group treated with F (1-3 mg/100 g body weight) developed a severe glomerulonephritis similar to the control group; (b) the groups treated with F (2-0 mg/100 g body weight) or with MTX-F showed progressively lower proteinuria, less severe histological changes and less intense fluorescence due to autologous antibodies. The best results were observed in the MTX-F group and in the F group treated from the 6th day. These groups presented at the 71st day proteinuria of 84 and 91 mg as compared to 312 mg in the control group, and minimal hislological lesions as compared to glomerulosclerosis and tubular atrophy in the control group. We concluded that either F or MTX-F produced significant improvement of nephrotoxic nephritis due to inhibition of autologous antibody production. [ABSTRACT FROM AUTHOR]
- Published
- 1984
21. Immunological assessment and its predictive role in malnourished infants with diarrhoea and/or systemic infections.
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Maffei, Helga V. L., Monteiro, Cassia M. C., Iwasso, Maria T. R., Mota, Norma G. S., Cun, Paulo R., Maffei, H V, Monteiro, C M, Iwasso, M T, Mota, N G, and Curi, P R
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- 1988
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22. Oxidative metabolism of lansoprazole by human liver cytochromes P450.
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Pichard, L, Curi-Pedrosa, R, Bonfils, C, Jacqz-Aigrain, E, Domergue, J, Joyeux, H, Cosme, J, Guengerich, F P, and Maurel, P
- Abstract
The aim of this work was to identify the form(s) of human cytochrome P450 (P450) involved in the hepatic biotransformation of lansoprazole to its two main metabolites, i.e., the sulfone and the hydroxy derivative. In liver microsomes, the production of the sulfone of lansoprazole correlated with the level of P450 3A4, cyclosporin oxidase, and the production of the hydroxy derivative, as well as of omeprazole sulfone. The production of hydroxylansoprazole moderately correlated with the level of P450 3A4, cyclosporin oxidase, and (S)-mephenytoin 4'-hydroxylase. The production of the sulfone and of the hydroxy derivative of lansoprazole was significantly inhibited by anti-P450 3A4 antibodies, by cyclosporin and ketoconazole, and by tolbutamide. Anti-P450 2C8 and 2C3 antibodies moderately inhibited the biotransformation of lansoprazole, whereas they completely inhibited (S)-mephenytoin 4'-hydroxylase activity under the same conditions. In primary cultures of human hepatocytes, the biotransformation of lansoprazole and the oxidation of cyclosporin were strongly increased by rifampicin and phenobarbital, whereas (S)-mephenytoin 4'-hydroxylation was not. beta-Naphthoflavone did not induce the formation of the sulfones but stimulated the production of hydroxylansoprazole. Among several forms of cDNA-expressed human P450s, 3A4 generated significant amounts of the sulfones of lansoprazole and omeprazole and 2C18 was active for the production of hydroxylansoprazole but inactive in the 4'-hydroxylation of (S)-mephenytoin. We conclude that P450 3A4 is the major enzyme involved in the production of the sulfone of lansoprazole and that this P450, as well as P450 2C18 and/or another 2C-related form, could contribute to the production of hydroxylansoprazole.
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- 1995
23. Effect of vaccination and the immunomodulators bacillus of Calmette-Guerin, Avridine and Propionibacterium acnes on rabies in mice
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Megid, J., Peracolli, M. T. S., Curi, P. R., Zanetti, C. R., Cabrera, W. H., Vassao, R., and Ito, F. H.
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- 1998
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24. Omeprazole and lansoprazole are mixed inducers of CYP1A and CYP3A in human hepatocytes in primary culture.
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Curi-Pedrosa, R, Daujat, M, Pichard, L, Ourlin, J C, Clair, P, Gervot, L, Lesca, P, Domergue, J, Joyeux, H, and Fourtanier, G
- Abstract
The ability of several gastric antiulcer drugs including lansoprazole, cimetidine and ranitidine to affect the expression of human liver microsomal cytochromes P450 comparatively to omeprazole, reported previously to be a CYP1A inducer, was evaluated in primary cultures of human hepatocytes. Poly (A)+ RNA and microsomes extracted from the cells were analyzed in Northern and Western blots with specific cDNA probes and antibodies, and assayed for form-specific monoxygenase activities. Lansoprazole induced both CYP1A1 and CYP1A2 as omeprazole and did not apparently bind to the aryl hydrocarbon receptor with high affinity. Omeprazole sulfone was not an inducer of CYP1A. Omeprazole, omeprazole sulfone and lansoprazole induced CYP3A in approximately 50% of tested cultures, whereas 100% of tested cultures responded to omeprazole and to rifampicin in terms of CYP1A and CYP3A induction, respectively. Finally, cimetidine and ranitidine were not inducers. We conclude that omeprazole and lansoprazole constitute a new class of mixed inducers of CYP1A and CYP3A in human hepatocytes in primary culture and that the induction of CYP3A in response to these molecules could be polymorphic in humans.
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- 1994
25. EFFECT OF BACILLUS OF CALMETTE-GUÉRIN, AVRIDINE AND Propionibacterium acnes AS IMMUNOMODULATORS ON RABIES IN MICE.
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MEGID, J., PERAÇOLI, M. T. S., CURI, P. R., ZANETTI, C. R., CABRERA, W. H., VASSAO, R., and ITO, F. H.
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- 1999
- Full Text
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26. Platelet activation following application of an Esmarch bandage and tourniquet in rabbits
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Winston Bonetti Yoshida, Thomazini, I. A., Carvalho, I., Lastória, S., Curi, P. R., Maffei, F. H., and Universidade Estadual Paulista (UNESP)
- Abstract
Made available in DSpace on 2022-04-29T08:42:21Z (GMT). No. of bitstreams: 0 Previous issue date: 1989-12-01 The present study evaluates platelet activation following application of an Esmarch bandage and a tourniquet, procedures commonly employed to provide a bloodless operative field during limb surgery. Platelet aggregation was increased in blood samples taken from rabbits 60 min after an Esmarch bandage was applied to one thigh and immediately released. When this treatment was combined with the application of a tourniquet for 60 min, a procedure which alone did not affect platelet aggregation, results were similar to those obtained following the Esmarch bandage alone. These data suggest that tissue compression produced by application of an Esmarch bandage, but not the ischemia derived from the tourniquet, produced platelet aggregation. Departamento de Cirurgia e Ortopedia, Hospital das Clínicas, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Brasil.
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- 1989
27. Postnatal growth of fibres on M. gracilis (pars caudalis) in both sexes of rat
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Dall Pai, V., Costa, I. R.D.S., Curi, P. R., and Universidade Estadual Paulista (UNESP)
- Abstract
Made available in DSpace on 2022-04-29T08:42:14Z (GMT). No. of bitstreams: 0 Previous issue date: 1982-12-01 Measurements of cross sectional area on individual fibres of M. gracilis (pars caudalis) of Wistar rats of both sexes of different ages were done. Growth equations pattern and growth rates equations pattern of each muscle fibre type were also determined. In rats 12 days old, muscle fibres present a somewhat uniform SDH activity. By 23 days and thereafter, SDH technique revealed a mixed population of red, intermediate and white fibres. There was a close relationship between cross sectional area and age, where each fibre type presents a distinct exponential growth curve pattern. The highest growth rates were observed at 23 and 45 days. After this age, a marked fall in growth rates occurs, except for white fibres, where this decrease was less intense. Red and intermediate muscle fibers tend to stabilize their growth earlier than white fibres. Dept. Morphol., State Univ. 'Julio de Mesquita Filho', Botucatu, Sao Paulo
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- 1982
28. Does the oxygen tension of coronary sinus blood reflect myocardial oxygen tension?
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Cicogna, A. C., Paulo Tucci, Spadaro, J., Curi, P. R., Lucchiari, P. H., and Universidade Estadual Paulista (UNESP)
- Abstract
Made available in DSpace on 2022-04-29T08:42:20Z (GMT). No. of bitstreams: 0 Previous issue date: 1989-12-01 Coronary sinus blood oxygen tension (CSpO2) and myocardial oxygen tension (MpO2) were measured simultaneously during cardiac ischemia and reperfusion. Oxygen tension was measured using a polarographic method. Myocardial ischemia caused a reduction (5 +/- 1.5%; P less than 0.05) in CSpO2 and a decrease (56.5 +/- 10.1%; P less than 0.001) in MpO2. Reperfusion induced a rapid but transient increase (35.9 +/- 4.3%; P less than 0.001) in CSpO2 above the basal state while MpO2 returned gradually to the basal state. These results indicate that CSpO2 is of little value for the detection of changes in myocardial oxygen metabolism during the initial phase (seconds) of cardiac reperfusion. Departamento de Clínica Médica, Faculdade de Medicina de Botucatu, Brasil.
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- 1989
29. Treatment of rat nephrotoxic nephritis. Use of 5-fluorouracil or methotrexate-5-fluorouracil association
- Author
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Almeida, D. B. de, Curi, P. R., and Universidade Estadual Paulista (Unesp)
- Subjects
Male ,kidney ,Fluorescent Antibody Technique ,methotrexate 5 fluorouracil ,Kidney ,Kidney Function Tests ,methotrexate ,fluorouracil ,Glomerulonephritis ,glomerulus basement membrane antibody ,Animals ,rat ,immune complex nephritis ,antibody production ,therapy ,nonhuman ,Animal ,animal model ,Rats, Inbred Strains ,drug therapy ,Rats ,Methotrexate ,Drug Therapy, Combination ,Fluorouracil ,proteinuria ,Research Article - Abstract
Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-26T22:09:26Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:27:59Z : No. of bitstreams: 1 2-s2.0-0021163981.pdf: 1755150 bytes, checksum: 8244c1234bfbba06b25763a87bb75eac (MD5) Made available in DSpace on 2014-05-26T22:09:26Z (GMT). No. of bitstreams: 0 Previous issue date: 1984-01-01 To evaluate the effect of 5-fluorouracil (F) and methotrexate-5-fluorouracil association (MTX-F) on nephrotoxic nephritis, seven groups of 10 rats were inoculated with anti-rat glomerular basement membrane serum (AGBMS); five groups were treated with different doses of F, beginning on the 2nd or the 6th day, one group with MTX-F beginning on the 2nd day and one group (control) with distilled water. Twenty-four hour proteinuria was determined weekly until the 71st day. The kidneys were examined histologically and by immunofluorescence. The group treated with F (1.3 mg/100 g body weight) developed a severe glomerulonephritis similar to the control group; (b) the groups treated with F (2.0 mg/100 g body weight) or with MTX-F showed progressively lower proteinuria, less severe histological changes and less intense fluorescence due to autologous antibodies. The best results were observed in the MTX-F group and in the F group treated from the 6th day. These groups presented at the 71st day proteinuria of 84 and 91 mg as compared to 312 mg in the control group, and minimal histological lesions as compared to glomerulosclerosis and tubular atrophy in the control group. We concluded that either F or MTX-F produced significant improvement of nephrotoxic nephritis due to inhibition of autologous antibody production.
- Published
- 1984
30. Techniques for temporary shunting of carotid arteries: Experimental study in dogs
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Winston Bonetti Yoshida, Curi, P. R., Lastoria, S., Maffei, F. H. A., and Universidade Estadual Paulista (UNESP)
- Abstract
Made available in DSpace on 2022-04-29T08:42:16Z (GMT). No. of bitstreams: 0 Previous issue date: 1985-01-01 Department of Surgery and Orthopaedics, Faculty of Medicine of Botucatu, University Estadual Paulista, Sao Paulo
- Published
- 1985
31. Determination of the sample size and distribution of the ABO and Rh blood groups in Botucatu, Sao Paulo, Brazil
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Curi, P. R. and Kroll, L. B.
- Abstract
Made available in DSpace on 2022-04-28T18:53:30Z (GMT). No. of bitstreams: 0 Previous issue date: 1976-01-01 Dept. Matemat. Estatistica, Fac. Ci. Med. Biol., Botucatu
- Published
- 1976
32. Comparative study of the action of topical heparinoids on the evolution of experimental thrombophlebitis
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Mattar, L., Maffei, F. H. A., Lastoria, S., Winston Bonetti Yoshida, Rollo, H. A., Fabris, V. E., Curi, P. R., and Universidade Estadual Paulista (UNESP)
- Abstract
Made available in DSpace on 2022-04-29T08:42:18Z (GMT). No. of bitstreams: 0 Previous issue date: 1988-01-01 Departamento de Cirurgia e Ortopedia, Faculdade de Medicina de Botucatu, UNESP, 18610 Botucatu, SP
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- 1988
33. Number of muscular fibers by microscopic field: A simple and efficient method to study denervation
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Fausto Viterbo de Oliveira Neto, Trindade, J. C. S., Pai, V. D., and Curi, P. R.
- Abstract
Made available in DSpace on 2022-04-28T18:53:57Z (GMT). No. of bitstreams: 0 Previous issue date: 1989-12-01 An experimental research was performed in dogs to evaluate the changes in gracilis muscle fibers when this muscle is submitted to denervation sectioning its motor nerve. Two experimental groups of six dogs each were used. Animals in Group A were sacrificed 30 ays after denervation of the gracilis muscle, ans animals in Group B were sacrificed 60 days after denervation. The normal gracilis muscle of the opposite leg was used as control. The degree of denervation was evaluated by two parameters: 1) the area of the cross section of the muscular fibers was measured by a planimeter; 2) the number of complete fibers seen in a specific microscopic field. Animals in both groups had atrophy of the muscular fibers, however atrophy was more intense in Group B (60 days) than in Group A (30 days). Conclusion was that the wieght of the denervated muscle is not an accurate method to study the evolution of the degenerating proces although it expresses the muscular atrophy resulting from the denervation. The number of muscular fibers in the microscopic field and the areas of the cross section of the muscular fibers obtained by planimetry are accurate parameters to detect the progress of muscular changes resulting from denervation. considering that it is easier to count the number of muscular fibers in the microscopic field, the authors propose the use of this preferential method in the study of the evolution of muscular changes due to muscle denervation. School of Medicine of Botucatu of the University of the State of Sao Paulo, Sao Paulo
- Published
- 1989
34. Functional and ultrastructural evaluation of myocardial protection provided by intermittent coronary sinus perfusion in the isolated dog heart
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De-Andrade, R. R., Paulo Tucci, Silva, M. A., Oliveira, R. A., Gregorio, E. A., Curi, P. R., Hossne, W. S., and Universidade Estadual Paulista (UNESP)
- Abstract
Made available in DSpace on 2022-04-28T19:53:50Z (GMT). No. of bitstreams: 0 Previous issue date: 1991-01-01 1. The protection offered by intermittent perfusion of cardioplegic solution through the coronary sinus was investigated in isovolumic blood-perfused dog heart preparations submitted to 60 min of ischemia and 45 min of reperfusion. 2. The preparations were divided into three treatment groups: a) coronary sinus, consisting of preparations (N = 10) perfused through the coronary sinus under 40 cm water pressure; b) aortic, consisting of preparations (N = 10) perfused through the aortic stump under 100 mmHg pressure; c) control, consisting of hearts (N = 9) that were not perfused with cardioplegic solution. 3. Properties of contractile capacity and relaxation were markedly impaired in the control group but were preserved to a comparable extent in the groups perfused with cardioplegic solution through the aorta and coronary sinus. Developed pressure decreased in the control group (before ischemia: 70 +/- 5.5 mmHg; after reperfusion: 35 +/- 12 mmHg; P less than 0.05) and didn't vary in the aortic group (from 69 +/- 4 mmHg to 65 +/- 13 mmHg; P greater than 0.05) and coronary sinus group (from 69 +/- 4.6 mmHg to 60 +/- 10 mmHg; P greater than 0.05). Myocardial relaxation was evaluated by the +/- dp/dt ratio. In the control group there was impairment of myocardial relaxation as indicated by an increase of this index after reperfusion (from 1.05 +/- 0.05 to 1.46 +/- 0.23; P less than 0.05), whereas in the aortic (from 1.10 +/- 0.13 to 1.15 +/- 0.20; P greater than 0.05) and the coronary sinus (from 1.03 +/- 0.14 to 1.08 +/- 0.16; P greater than 0.05) groups there was no variation. Ultrastructural changes in the myocardium were negligible in all three groups at the end of reperfusion. 4. We conclude that intermittent perfusion of a hypothermic cardioplegic solution through the coronary sinus is effective for the protection of the myocardium during total ischemia. Departamento de Cirurgia e Ortopedia Faculdade de Medicina de Botucatu Universidade Estadual Paulista Departamento de Cirurgia e Ortopedia Faculdade de Medicina de Botucatu Universidade Estadual Paulista
35. Changes in myocardial and coronary sinus blood oxygen tension induced by asphyxia and reoxygenation
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Cicogna, A. C., Spadaro, J., Paulo Tucci, Bregagnollo, E. A., Rodrigues, M. A., Curi, P. R., Lucchiari, P. H., and Universidade Estadual Paulista (UNESP)
- Abstract
Made available in DSpace on 2022-04-28T19:53:47Z (GMT). No. of bitstreams: 0 Previous issue date: 1988-01-01 1. This study analyzes variations of oxygen tension induced by asphyxia in the myocardium (MpO2) and coronary sinus blood (CSpO2) of the anesthetized open-chest dog. Oxygen tension was measured polarographically and arterial blood pressure and coronary blood flow were recorded simultaneously. 2. Asphyxia increased arterial pressure and coronary blood flow but decreased both MpO2 and CSpO2. 3. During the reoxygenation phase, arterial pressure and coronary flow decreased gradually. Reoxygenation induced a rapid but transient increase in CSpO2 above control levels. In contrast, MpO2 returned gradually to the basal state. 4. The mechanism(s) involved in the differential effects of asphyxia followed by reoxygenation on MpO2 and CSpO2 remain to be elucidated. Departamento de Clínica Médica Faculdade de Medicina de Botucatu Universidade Estadual de São Paulo Departamento de Clínica Médica Faculdade de Medicina de Botucatu Universidade Estadual de São Paulo
36. Magnesium levels in nutrient solution and common bean (Phaseolus vulgaris L. cv Carioca) development. Evaluation of the growth relations and assimilate partitioning,Níveis de magnésio em solução nutritiva e o desenvolvimento do feijoeiro (Phaseolus vulgaris L. cv Carioca). Avaliação de relações de crescimento e partição de assimilados
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Boaro, C. S. F., Moraes, J. A. P. V., João Domingos Rodrigues, Pedras, J. F., Ono, E. O., and Curi, P. R.
37. Magnesium, calcium and potassium in seeds and cotyledons of common bean and its translocation to the young plants,Magnésio, cálcio e potássio em sementes e cotilédones de feijoeiros e sua transferência para plantas jovens
- Author
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Boaro, C. S. F., Moraes, J. A. P. V., João Domingos Rodrigues, Ono, E. O., Pedras, J. F., and Curi, P. R.
38. Evaluation of cane stillage in substitution of water in finishing feedlot .2. behavior and metabolic profile
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Mário Arrigoni, Silveira, Antonio Carlos, Furlan, L. R., Parre, C., Ciniro Costa Costa, Curi, P. R., and Universidade Estadual Paulista (Unesp)
- Subjects
BLOOD PARAMETERS ,ANIMAL BEHAVIOR - Abstract
Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2014-02-26T17:05:54Z No. of bitstreams: 0 Made available in DSpace on 2014-02-26T17:05:54Z (GMT). No. of bitstreams: 0 Previous issue date: 1994-01-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:21:10Z No. of bitstreams: 0 Made available in DSpace on 2014-05-20T15:21:10Z (GMT). No. of bitstreams: 0 Previous issue date: 1994-01-01 Para a avaliação dos parâmetros etológicos, durante 24 horas ininterruptas, a cada 30 dias, em um período de 90 dias de confinamento, 30 animais – 15 da raça Canchim e 15 Nelore – foram distribuídos nos seguintes tratamentos: água (A), vinhaça + óxido de magnésio (V) e vinhaça + óxido de magnésio + bicarbonato de sódio (V+B). Por ocasião das pesagens a cada 28 dias, coletaram-se amostras de sangue para determinação do perfil metabólico. Verificou-se que os tratamentos não influenciaram (P > 0,05) o comportamento animal nem o perfil metabólico, estando os valores médios obtidos dentro dos intervalos de normalidade, sendo para Canchim e Nelore, respectivamente: Alimentação - 270 e 223 min; Ruminação - 374 e 356 min; Ócio - 745 e 863; Glicose - 86 e 88 mg/dl; Uréia -10 e 13 mg/dl; Ácido Úrico -1,3 e 1,2 mg/dl; Proteínas totais - 7,0 e 6,8 g/dl; Albumina - 3,1 e 3,1 g/dl; Creatinina - 1,5 e 1,6 mg/dl; Sódio - 140 e 142 meq/dl; Potássio - 4,2 e 4,3 meq/1 e Cálcio 10,0 e 9,8 mg/dl. Concluíu-se que: A vinhaça líquida em substituição à água não alterou os parâmetros etológico e perfil metabólico dos bovinos dos grupos genéticos, Nelore e Canchim e fase de terminação em confinamento. Fifteen animals from Canchim group and fifteen from Nelore were observed in the following treatments: water (A), molasses soluble + magnesium oxide (V) and molasses soluble + magnesium oxide + sodium bicarbonate (V+B). They were observed during continuous 24 hours every 30 days up to 90 days periods. During the weighting, every 28 days blood samples were collected to determine metabolic outline. Treatments did not affect (P>.05) animal behaviour on metabolic and the obtained mean values were within the normal range. They were, respectively for Canchim and Nelore: Feeding 270 and 223 minutes; Rumination 374 and 356 minutes; Idleness 745 and 863 minutes; Glicose 86 and 88 mg/dl; Urea 10 and 23 mg/dl: Uric acid 1,3 and 1,2 mg/dl; Total protein 7,0 and 6,8 g/dl; Albumin 3,1 and 3,1 g/dl; Creatinin 1,5 and 1,6 mg/dl; Sodium 140 and 142 meq/dl; Potassium 4,2 and 4,3 meq/1 and Calcium 10,0 and 9,8 mg/dl. It was concluded that molasses soluble as a substitute of water has not changed the ethologic parameters neither metabolic outline of both genetic group when in finishing feedlot. UNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO,FMVZ,CAMPUS BOTUCATU,CAIXA POSTAL 502,BR-18618000 BOTUCATU,SP,BRAZIL UNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO,FMVZ,CAMPUS BOTUCATU,CAIXA POSTAL 502,BR-18618000 BOTUCATU,SP,BRAZIL
39. Effects of nutritional restriction on the performance in feedlot young bulls,Efeitos da restrição alimentar no desempenho de bovinos jovens confinados
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Mário Arrigoni, Vieira, P. D. F., Silveira, A. C., Furlan, L. R., Costa, C., Chardulo, L. A. L., and Curi, P. R.
40. Avaliação da vinhaça líquida em substituição à água na terminação de bovinos em confinamento. 1. Desempenho
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Mário Arrigoni, Silveira, Antonio Carlos, Furlan, L. R., Parre, C., Ciniro Costa Costa, Curi, P. R., and Universidade Estadual Paulista (Unesp)
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Bicarbonato de Sódio ,oxido de mangnesio ,cana-de-acucar ,NELORE ,CANCHIM ,GENETIC GROUPS ,Grupos geneticos ,CORN SILAGE ,silagem de milho ,SODIUM BICARBONATE ,SUGARCANE ,MAGNESIUM OXIDE - Abstract
Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2014-02-26T17:05:43Z No. of bitstreams: 0 Made available in DSpace on 2014-02-26T17:05:43Z (GMT). No. of bitstreams: 0 Previous issue date: 1993-11-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:28:16Z No. of bitstreams: 0 Made available in DSpace on 2014-05-20T15:28:16Z (GMT). No. of bitstreams: 0 Previous issue date: 1993-11-01 O presente estudo teve por objetivo avaliar o desempenho de bovinos em fase de terminação em confinamento, recebendo vinhaça em substituição à água. Foram utilizados 243 bovinos de dois grupos genéticos, Canchim e Nelore, em um período experimental de 90 dias, com pesagens a cada 28 dias. O delineamento experimental foi o inteiramente aleatorizado, em um fatorial 2 x 3, sendo utilizadas duas raças - Nelore (Nel) e Canchim (Can) - e três tratamentos: água (A), vinhaça + óxido de magnésio (V) e vinhaça + óxido de magnésio + bicarbonato de sódio (V + B). A dieta para todos os tratamentos era composta de 70% de silagem de milho e 30% de cana-de-açúcar picada, ad libitum, acrescida de 1 kg e quirera de milho e 1,5 kg de levedura. Independentemente dos tratamentos, os animais Can revelaram maior ganho de peso (p > 0,01) em relação aos Nel, com 1,35 e 1,22 kg/cab/dia, respectivamente. Considerando-se os tratamentos, ambas as raças apresentaram maior ganho de peso (p > 0,01) no V + B, com 1,44 e 1,32 kg/cab/dia, para Can e Nel, respectivamente, em comparação aos demais: Can (A) = 1,30; Can (V) = 1,31; Nel (A) = 1,16 e Nel (V) = 1,20 kg/cab/dia. O tratamento V + B proporcionou ainda, uma tendência (0,05 < p < 0,10) de melhor conversão alimentar, o que evidencia o efeito positivo da vinhaça, quando associada aos compostos neutralizadores do pH ruminal. During 90 days 243 finishing feedlot animals from two genetic groups, were weighed every 28 days in a randomized experimental procedure in a 2 x 3 factorial arrangement, with two breeds - Nelore (Nel) and Canchim (Can) - and three treatments: water (A), cane stillage + magnesium oxide (V) and cane stillage + magnesium oxide + sodium bicarbonate (V + B). The diet for all treatments was composed of 70% of corn silage and 30% of chopped sugar cane ad libitum plus 1 kg of ground corn and 1,5 kg of soluble yeast per animal. Results showed higher weight gain (P < 0,01) of the Can group relation to those of Nel, having respectively 1,35 and 1,22 kg/head/day. Both Can and Nel groups showed higher weight gain (P
41. Lumbar sympathectomy and distal arteriovenous fistula as adjuncts to prevent arterial rethrombosis after thrombectomy: Experimental study in dogs
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Winston Bonetti Yoshida, Maffei, F. H. A., Lastoria, S., Curi, P. R., Rollo, H. A., and Universidade Estadual Paulista (UNESP)
- Abstract
Made available in DSpace on 2022-04-29T08:42:19Z (GMT). No. of bitstreams: 0 Previous issue date: 1988-01-01 Department of Surgery and Orthopaedics, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, 18610 Botucatu, Sao Paulo
42. Effects of phosphorus and nitrogen enrichment on the phytoplankton in a tropical reservoir (Lobo Reservoir, Brazil)
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Henry, R., primary, Tundisi, J. G., additional, and Curi, P. R., additional
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- 1984
- Full Text
- View/download PDF
43. Chromosome aberrations in lymphocyte cultures from paracoccidioidomycosis patients
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Freire-Maia, D. V., Garcia, M. G., Mendes, R. P., Marques, S. A., Curi, P. R., and Souza, L. R.
- Abstract
Blood cell lymphocyte chromosomes from untreated (UT) and clinically-cured (CC) patients with paracoccidioidomycosis and from healthy (control) people (CO) were studied. The frequency of aneuploid cells in the UT patients was higher than in the CC and CO individuals. The frequency of metaphase cells with premature centromere division was significantly higher in the UT than in the CC and CO group. No structural aberration and no statistically significant difference in the frequency of polyploidy was observed in the three groups studied. Our findings are indicative of an aneugenic (aneuploidy-inducing) action of infection by Paracoccidioides brasiliensis.
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- 1994
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44. Antithrombotic effect of Lonomia obliqua caterpillar bristle extract on experimental venous thrombosis.
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Prezoto BC, Maffei FH, Mattar L, Chudzinski-Tavassi AM, and Curi PR
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- Animals, Anticoagulants therapeutic use, Arthropod Venoms therapeutic use, Bleeding Time, Factor XIII analysis, Fibrinolytic Agents therapeutic use, Jugular Veins drug effects, Male, Rabbits, Rats, Rats, Wistar, Venae Cavae drug effects, Anticoagulants pharmacology, Arthropod Venoms pharmacology, Blood Coagulation drug effects, Fibrinolytic Agents pharmacology, Venous Thrombosis prevention & control
- Abstract
The venom of Lonomia obliqua caterpillar may induce a hemorrhagic syndrome in humans, and blood incoagulability by afibrinogenemia when intravenously injected in laboratory animals. The possible antithrombotic and thrombolytic activities of L. obliqua caterpillar bristle extract (LOCBE) were evaluated in this study. The minimal intravenous dose of the extract necessary to induce afibrinogenemia and anticoagulation was 3.0 and 10.0 microg protein/kg body weight for rabbits and rats, respectively. In rabbits, this dose induced total blood incoagulability for at least 10 h and did not reduce the weight of preformed venous thrombi, in contrast to streptokinase (30,000 IU/kg). In rats, pretreatment with 5.0 and 10.0 microg/kg LOCBE prevented the formation of thrombi induced by venous stasis or by injury to the venous endothelium. The dose of 5.0 microg/kg LOCBE did not modify blood coagulation assay parameters but increased bleeding time and decreased plasma factor XIII concentration. When the extract was administered to rats at the dose of 10.0 microg/kg, the blood was totally incoagulable for 6 h. These data show that LOCBE was effective in preventing experimental venous thrombosis in rats, justifying further studies using purified fractions of the extract to clarify the mechanisms of this effect.
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- 2002
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45. Effect of the bacillus of Calmette-Guérin, Propionibacter acnes and avridine as immunomodulators in antirabies vaccination of mice using the Fuenzalida-Palacios mouse brain vaccine.
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Megid J, Peraçolli MT, Curi PR, Zanetti CR, Cabrera WH, Vassao R, and Ito FH
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- Animals, Antibodies, Viral biosynthesis, Antiviral Agents immunology, Brain virology, Female, Humans, Injections, Intramuscular, Interferon Inducers immunology, Mice, Neutralization Tests, Rabies prevention & control, Adjuvants, Immunologic therapeutic use, BCG Vaccine immunology, Diamines immunology, Propionibacterium acnes immunology, Rabies immunology, Rabies Vaccines immunology
- Abstract
Using the laboratory mice, Fuenzalida-Palacios mouse brain human rabies vaccine was administered in groups of animals previously inoculated with rabies virus and then submitted to treatments with the immunomodulators onco-BCG, avridine and Propionibacterium acnes. Humoral and cellular immune responses were evaluated through the macrophage inhibition factor (MIF), intra-pad inoculation (IPI) and serum neutralization (SN) tests and by the detection of gamma-interferon (IFN-gamma). The IPI test was not effective in detecting the response of delayed-type hypersensitivity, contrary to MIF, which showed the immune cellular response. Higher levels of IFN-gamma were observed in the groups of mice vaccinated and treated with avridine and P. acnes. Although immunomodulating activities have been detected, the use of adjuvants with the Fuenzalida-Palacios type vaccine in mice did not reveal any encouraging results.
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- 1999
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46. Serial Mitsuda tests for identification of reactional tuberculoid and reactional borderline leprosy forms.
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Lastoria LC, Opromolla DV, Fleury RN, Habermann F, and Curi PR
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- Adolescent, Adult, Aged, Child, Female, Humans, Leprosy, Borderline microbiology, Leprosy, Borderline pathology, Leprosy, Tuberculoid microbiology, Leprosy, Tuberculoid pathology, Male, Middle Aged, Lepromin, Leprosy, Borderline diagnosis, Leprosy, Tuberculoid diagnosis
- Abstract
The authors studied the Mitsuda reaction in 37 leprosy patients (18 reactional tuberculoid, 19 reactional borderline cases) and compared the results with clinical findings, histopathology and bacilloscopy. Evaluation of the Mitsuda reaction was carried out on days 30, 60, 90 and 120. Most of the reactional tuberculoid patients showed a Mitsuda reaction of +3 in opposition to the reactional borderline patients who showed only +. Bacilloscopic analysis revealed that in 75% of the reactional tuberculoid cases there were rare or no bacilli; bacilli were present in 95% of the reactional borderline cases. The authors conclude that reactional tuberculoid cases have a greater ability to clear bacilli than reactional borderline cases, and that the Mitsuda reaction is a useful tool for the differentiation between these two types of leprosy.
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- 1998
47. The use of glucan as immunostimulant in the treatment of paracoccidioidomycosis.
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Meira DA, Pereira PC, Marcondes-Machado J, Mendes RP, Barraviera B, Pellegrino Júnior J, Rezkallah-Iwasso MT, Peracoli MT, Castilho LM, Thomazini I, Da Silva CL, Foss NT, and Curi PR
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- Adjuvants, Immunologic administration & dosage, Adolescent, Adult, Aged, Amphotericin B therapeutic use, Anti-Infective Agents therapeutic use, Antibodies, Fungal analysis, Antifungal Agents therapeutic use, Blood Sedimentation, CD3 Complex analysis, CD4 Antigens analysis, CD4 Lymphocyte Count, CD4-CD8 Ratio, CD8 Antigens analysis, Drug Therapy, Combination, Glucans administration & dosage, Humans, Ketoconazole therapeutic use, Male, Middle Aged, Paracoccidioides immunology, Paracoccidioidomycosis blood, Phytohemagglutinins immunology, Skin Tests, Sulfadiazine therapeutic use, Sulfanilamides therapeutic use, T-Lymphocyte Subsets immunology, Trimethoprim, Sulfamethoxazole Drug Combination therapeutic use, Tumor Necrosis Factor-alpha analysis, Adjuvants, Immunologic therapeutic use, Glucans therapeutic use, Immunization, Paracoccidioidomycosis drug therapy, Paracoccidioidomycosis immunology, beta-Glucans
- Abstract
A group of 10 patients, nine of them seriously infected with Paracoccidioides brasiliensis (G1), received glucan (beta-1,3 polyglucose) as an immunostimulant intravenously once a week for one month, followed by monthly doses (10 mg) over an 11-month period, together with a specific anti-fungal agent as an immunostimulant. A second group of eight moderately infected patients (G2) was treated with only the anti-fungal agent. Among the patients in G1, there was only one case of relapse compared with five in G2. Values for the erythrocyte sedimentation rate (ESR) showed a significant difference (P < 0.001) post-treatment in G1 patients, when compared with the pretreatment levels. There was also a significant reduction (P < 0.001) in the level of serum antibodies to P. brasiliensis in the G1 patients in post-treatment examinations. The phytohemagglutinin (PHA) skin test showed a positive reaction among the patients in G1 (P < 0.01) post-treatment and there was a tendency towards an increase in the number of CD4+ T lymphocytes in both groups after treatment. The serum level of tumor necrosis factor (TNF) proved to be significantly higher (P < 0.02) in the G1 patients during treatment. In the G1 patients, the correlation between ESR and TNF tended to be negative whereas that between ESR and serum antibodies was positive. The present results indicate that the patients who received glucan, in spite of being more seriously ill, had a stronger and more favorable response to therapy.
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- 1996
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48. [Relations among arm, arm muscle, arm fat areas and menarche in adolescents in the municipality of Botucatu].
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Goldberg TB, Colli AS, and Curi PR
- Abstract
The authors show the relations among arm circumference, arm muscle and arm fat areas with or without menarche, by carrying out an anthropometric study in 717 adolescents in the municipality of Botucatu. It must be emphasized that those adolescents who had already menstruated presented significantly higher nutritional indicators than those who had not menstruated yet. There was an increase in fat tissue and lean body mass in those adolescents who had already menstruated. Body changes might be expressed by calculating muscle and arm fat areas using triceps skinfold and arm circumference.
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- 1996
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- View/download PDF
49. [Sodium diclofenac effect, after interruption of the stercoraceous peritonitis, on the rat colon. Study of mechanical resistance and collagen concentration].
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Verderese LR, Naresse LE, Leite CV, Mercadante MC, Sadatsune T, Curi PR, Burini RC, and Kobayasi S
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- Animals, Collagen metabolism, Colon drug effects, Colon metabolism, Feces, Random Allocation, Rats, Rats, Wistar, Tensile Strength drug effects, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Collagen drug effects, Colon physiopathology, Diclofenac pharmacology, Peritonitis physiopathology
- Abstract
Unlabelled: The objective of the present study was to investigate changes in colon wall in rats with fecal peritonitis (Per) associated with sodium diclofenac (SD) by studying breaking strength and tissue collagen concentration. The rats were divided into the following experimental groups: GROUP 1-SD: 60 animals injected intramuscularly with sodium diclofenac at the dose of 2 mg/kg body weight; GROUP 2-Per: 60 animals injected intraperitoneally with a suspension of human feces. Peritonitis was interrupted after six hours of evolution; GROUP 3-Per+SD: 60 animals injected intraperitoneally with a suspension of human feces and receiving SD according to the schedule used for Groups 1 and 2;, Control Group: 12 animals injected intramuscularly with physiological saline. The animals of Group 1, 2 and 3 were successively sacrificed 2, 4, 7, 14 and 21 days after interruption of peritonitis an/or the beginning of treatment. Under conditions of the experimental model and of the methods used, we conclude that sodium diclofenac, peritonitis and the peritonitis-sodium diclofenac association decrease the breaking strength and the concentration of tissue collagen in the colon segment.
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- 1995
50. Reactive oxygen generation by azomethine H: a new antimalarial drug.
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Novelli EL, Silva AM, Novelli JL, and Curi PR
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- Animals, Enzyme Activation drug effects, Lipid Peroxides blood, Male, Rats, Rats, Wistar, Superoxide Dismutase blood, Time Factors, Antimalarials pharmacology, Naphthalenesulfonates pharmacology, Oxygen metabolism, Thiosemicarbazones pharmacology
- Abstract
Superoxide radical (O2-) is a free radical that may be involved in various toxic processes. Cu-Zn superoxide dismutase catalyzes the dismutation of the superoxide free radical and protects cells from oxidative damage. A rat bioassay validated for the identification of the toxic effects of azomethine H revealed increased serum activities of amylase, alanine transaminase, and alkaline phosphatase. The lipoperoxide and bilirubin concentrations were also increased in animals that received azomethine H (1 g/kg) from ascorbic or hydrochloric acid solutions. Azomethine H increased Cu-Zn superoxide dismutase activity. This elevation of Cu-Zn superoxide dismutase activity was highest on the 7th day and was at levels comparable with those of control rats from day 60 onwards. Superoxide is an important intermediate in the action and toxicity of azomethine H.
- Published
- 1995
- Full Text
- View/download PDF
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