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2. Predicting a Prolonged Air Leak After Video-Assisted Thoracic Surgery, Is It Really Possible?

Author

Mancuso, M., Pernazza, F., Refai, M., Srella, F., Argnani, D., Marulli, G., De Palma, A., Bortolotti, L., Rizzardi, G., Solli, P.G., Dolci, G.P., Perkmann, R., Zaraca, F., Benvenuti, M., Gavezzoli, D., Cherchi, R., Ferrari, P., Mucilli, F., Camplese, P., Melloni, G., Mazza, F., Cavallesco, G., Maniscalco, P., Voltolini, L., Gonfiotti, A., Sollitto, F., Ardò, N., Pariscenti, G.L., Risso, C., Surrente, C., Lopez, C., Droghetti, A., Giovanardi, M., Breda, C., Giudice, Lo F., Alloisio, M., Bottoni, E., Spaggiari, L., Gasparri, R., Torre, M., Rinaldo, A., Nosotti, M., Tosi, D., Negri, G.P., Bandiera, A., Baisi, A., Raveglia, F., Stefani, A., Natali, P., Scarci, M., Pirondini, E., Curcio, C., Amore, D., Rena, O., Nicotra, S., Dell’ Amore, A., Bertani, A., Tancredi, G., Ampollini, L., Carbognani, P., Puma, F., Vinci, D., Cardillo, G., Carleo, F., Margaritora, S., Meacci, E., Luzzi, L., Ghisalberti, M., Crisci, R., Divisi, D., Lausi, P., Guerrera, F., Fontana, D., Beffa, V. Della, Morelli, A., Londero, F., Imperatori, A., Rotolo, N., Terzi, A., Viti, A., Infante, M., Benato, C., Zaraca, Francesco, Pipitone, Marco, Feil, Birgit, Perkmann, Reinhold, Bertolaccini, Luca, Curcio, Carlo, and Crisci, Roberto

Published
2021
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5. Energy spectra of KASCADE-Grande based on shower size measurements and different hadronic interaction models

Author

Kang, D., Apel, W. D., Arteaga-Velazquez, J. C., Bekk, K., Bertaina, M., Bluemer, J., Bozdog, H., Brancus, I. M., Cantoni, E., Chiavassa, A., Cossavella, F., Curcio, C., Daumiller, K., de Souza, V., Di Pierro, F., Doll, P., Engel, R., Engler, J., Fuchs, B., Fuhrmann, D., Gils, H. J., Glasstetter, R., Grupen, C., Haungs, A., Heck, D., Hoerandel, J. R., Huber, D., Huege, T., Kampert, K. -H., Klages, H. O., Link, K., Luczak, P., Ludwig, M., Mathes, H. J., Mayer, H. J., Melissas, M., Milke, J., Mitrica, B., Morello, C., Oehlschlaeger, J., Ostapchenko, S., Palmieri, N., Petcu, M., Pierog, T., Rebel, H., Roth, M., Schieler, H., Schoo, S., Schroeder, F. G., Sima, O., Toma, G., Trinchero, G. C., Ulrich, H., Weindl, A., Wochele, D., Wochele, J., and Collaboration, J. Zabierowski - KASCADE-Grande

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

KASCADE-Grande is dedicated for investigations of cosmic-ray air showers in the primary energy range from 10 PeV to 1 EeV. The multi-detector system allows us to reconstruct charged particles, electron and muon numbers for individual air showers with high accuracies. Based on the shower size ($N_{ch}$) spectra of the charged particle component, the all-particle energy spectrum of cosmic rays is reconstructed, where attenuation effects in the atmosphere are corrected by applying the constant intensity cut method. The energy calibration is performed by using CORSIKA simulations with high-energy interaction models QGSJET-II-2, QGSJET-II-4, EPOS 1.99 and SIBYLL 2.1, where FLUKA has been used as low-energy interaction model for all cases. In the different hadronic models, different abundances for shower particles are predicted. Such model differences in the observables will be compared and discussed in this contribution. Furthermore, by using data with increasing statistics, the updated energy spectra by means of different interaction models will be presented., Comment: 4 pages, paper presented at the International Cosmic Ray Conference, Rio De Janeiro, 2013, paper ID 0521

Published
2013
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6. Study of the muon content of very high-energy EAS measured with the KASCADE-Grande observatory

Author

Arteaga-Velazquez, J. C., Apel, W. D., Bekk, K., Bertaina, M., Bluemer, J., Bozdog, H., Brancus, I. M., Cantoni, E., Chiavassa, A., Cossavella, F., Curcio, C., Daumiller, K., de Souza, V., Di Pierro, F., Doll, P., Engel, R., Engler, J., Fuchs, B., Fuhrmann, D., Gils, H. J., Glasstetter, R., Grupen, C., Haungs, A., Heck, D., Hoerandel, J. R., Huber, D., Huege, T., Kampert, K. -H., Kang, D., Klages, H. O., Link, K., Luczak, P., Ludwig, M., Mathes, H. J., Mayer, H. J., Melissas, M., Milke, J., Mitrica, B., Morello, C., Oehlschlaeger, J., Ostapchenko, S., Palmieri, N., Petcu, M., Pierog, T., Rebel, H., Roth, M., Schieler, H., Schoo, S., Schroeder, F. G., Sima, O., Toma, G., Trinchero, G. C., Ulrich, H., Weindl, A., Wochele, D., Wochele, J., and Collaboration, J. Zabierowski - KASCADE-Grande

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The KASCADE-Grande detector is an air-shower array devoted to the study of primary cosmic rays with very high-energies (E = 10^{16} - 10^{18} eV). The instrument is composed of different particle detector systems suitable for the detailed study of the properties of Extensive Air Showers (EAS) developed by cosmic rays in the atmosphere. Among the EAS observables studied with the detector, the charged number of particles, the muon content (at different energy thresholds), and the number of electrons are found. By comparing the measurements of these air-shower parameters with the expectations from MC simulations, different hadronic interaction models can be tested at the high-energy regime with the KASCADE-Grande experiment. In this work, the results of a study on the evolution of the muon content of EAS with zenith angle, performed with the KASCADE-Grande instrument, is presented. Measurements are compared with predictions from MC simulations based on the QGSJET II, QGSJET II-04, SIBYLL 2.1 and EPOS 1.99 hadronic interaction models. A mismatch between experiment and simulations is observed. A similar problem is found for the evolution of the lateral distribution function of muons in the atmosphere., Comment: 4 pages, paper presented at the International Cosmic Ray Conference, Rio De Janeiro, 2013, paper ID 772

Published
2013

7. KASCADE-Grande measurements of energy spectra for elemental groups of cosmic rays

Author

Fuhrmann, D., Apel, W. D., Arteaga-Velazquez, J. C., Bekk, K., Bertaina, M., Bluemer, J., Bozdog, H., Brancus, I. M., Cantoni, E., Chiavassa, A., Cossavella, F., Curcio, C., Daumiller, K., de Souza, V., Di Pierro, F., Doll, P., Engel, R., Engler, J., Fuchs, B., Gils, H. J., Glasstetter, R., Grupen, C., Haungs, A., Heck, D., Hoerandel, J. R., Huber, D., Huege, T., Kampert, K. -H., Kang, D., Klages, H. O., Link, K., Luczak, P., Ludwig, M., Mathes, H. J., Mayer, H. J., Melissas, M., Milke, J., Mitrica, B., Morello, C., Oehlschlaeger, J., Ostapchenko, S., Palmieri, N., Petcu, M., Pierog, T., Rebel, H., Roth, M., Schieler, H., Schoo, S., Schroeder, F. G., Sima, O., Toma, G., Trinchero, G. C., Ulrich, H., Weindl, A., Wochele, D., Wochele, J., and Collaboration, J. Zabierowski - KASCADE-Grande

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The KASCADE-Grande experiment, located at KIT-Karlsruhe, Germany, consists of a large scintillator array for measurements of charged particles, N_ch, and of an array of shielded scintillation counters used for muon counting, N_mu. KASCADE-Grande is optimized for cosmic ray measurements in the energy range 10 PeV to 1000 PeV, thereby enabling the verification of a knee in the iron spectrum expected at approximately 100 PeV. Exploring the composition in this energy range is of fundamental importance for understanding the transition from galactic to extragalactic cosmic rays. Following earlier studies of elemental spectra reconstructed in the knee energy range from KASCADE data, we have now extended these measurements to beyond 100 PeV. By analysing the two-dimensional shower size spectrum N_ch vs. N_mu, we reconstruct the energy spectra of different mass groups by means of unfolding methods. The procedure and its results, giving evidence for a knee-like structure in the spectrum of iron nuclei, will be presented., Comment: 4 pages, paper presented at the International Cosmic Ray Conference, Rio De Janeiro, 2013, paper ID 0531, ICRC 2013 oral contribution

Published
2013

8. The <lnA> study in the primary energy range 10^{16} - 10^{17} eV with the Muon Tracking Detector in the KASCADE-Grande experiment

Author

Łuczak, P., Apel, W. D., Arteaga-Velázquez, J. C., Bekk, K., Bertaina, M., Blümer, J., Bozdog, H., Brancus, I. M., Cantoni, E., Chiavassa, A., Cossavella, F., Curcio, C., Daumiller, K., de Souza, V., Di Pierro, F., Doll, P., Engel, R., Engler, J., Fuchs, B., Fuhrmann, D., Gils, H. J., Glasstetter, R., Grupen, C., Haungs, A., Heck, D., Hörandel, J. R., Huber, D., Huege, T., Kampert, K. -H., Kang, D., Klages, H. O., Link, K., Ludwig, M., Mathes, H. J., Mayer, H. J., Melissas, M., Milke, J., Mitrica, B., Morello, C., Oehlschläger, J., Ostapchenko, S., Palmieri, N., Petcu, M., Pierog, T., Rebel, H., Roth, M., Schieler, H., Schoo, S., Schröder, F. G., Sima, O., Toma, G., Trinchero, G. C., Ulrich, H., Weindl, A., Wochele, J., and Zabierowski, J.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The KASCADE-Grande Muon Tracking Detector enables with high accuracy the measurement of directions of EAS muons with energy above 0.8 GeV and up to 700 m distance from the shower centre. Reconstructed muon tracks are used to investigate muon pseudorapidity (eta) distributions. These distributions are nearly identical to the pseudorapidity distributions of their parent mesons produced in hadronic interactions. Comparison of the eta distributions from measured and simulated showers can be used to test the quality of the high energy hadronic interaction models. In this context a comparison of the QGSJet-II-2 and QGSJet-II-4 model will be shown. The pseudorapidity distributions reflect the longitudinal development of EAS and, as such, are sensitive to the mass of the cosmic rays primary particles. With various parameters of the eta distribution, obtained from the MTD data, it is possible to calculate the mean logarithmic mass of CRs. The results of the analysis in the primary energy range 10^{16} eV - 10^{17} eV with the 1st quartile (Q1) of eta distribution will be presented., Comment: 4 pages, paper presented at the International Cosmic Ray Conference, Rio De Janeiro, 2013, paper ID 0528

Published
2013

9. The energy-spectrum of light primaries in the range from 10^{16.6} to 10^{18.2} eV

Author

Schoo, S., Apel, W. D., Arteaga-Velazquez, J. C., Bekk, K., Bertaina, M., Bluemer, J., Bozdog, H., Brancus, I. M., Cantoni, E., Chiavassa, A., Cossavella, F., Curcio, C., Daumiller, K., de Souza, V., Di Pierro, F., Doll, P., Engel, R., Engler, J., Fuchs, B., Fuhrmann, D., Gils, H. J., Glasstetter, R., Grupen, C., Haungs, A., Heck, D., Hoerandel, J. R., Huber, D., Huege, T., Kampert, K. -H., Kang, D., Klages, H. O., Link, K., Luczak, P., Ludwig, M., Mathes, H. J., Mayer, H. J., Melissas, M., Milke, J., Mitrica, B., Morello, C., Oehlschlaeger, J., Ostapchenko, S., Palmieri, N., Petcu, M., Pierog, T., Rebel, H., Roth, M., Schieler, H., Schroeder, F. G., Sima, O., Toma, G., Trinchero, G. C., Ulrich, H., Weindl, A., Wochele, D., Wochele, J., and Collaboration, J. Zabierowski - KASCADE-Grande

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Data of the Grande extension of the KASCADE experiment allows us to study extensive air showers induced by primary cosmic rays with energies above 10^{16} eV. The energy of an event is estimated in terms of the number of charged particles (Nch ) and the number of muons (N{\mu} ) measured at an altitude of 110 m a.s.l. While a combination of the two numbers is used for the energy, the ratio defines the primary mass (group). The spectrum of the combined light and medium mass components, recently measured with KASCADE-Grande, was found to be compatible with both a single power-law and a broken power-law in the energy range between 10^{16.3} and 10^{18} eV. In this contribution we will present the investigation of possible structures in the spectrum of light primaries with increased statistics both from a larger data set including more recent measurements and by using a larger fiducial area than in the previous study. With the better statistical accuracy and with optimized selection criteria for enhancing light primaries we have found evidence for a hardening (ankle) of the spectrum of the light component at an energy of 10^{17.08+-0.08} eV., Comment: 4 pages, paper presented at the International Cosmic Ray Conference, Rio De Janeiro, 2013, paper ID 0527

Published
2013

10. High-energy cosmic rays measured with KASCADE-Grande

Author

Haungs, A., Apel, W. D., Arteaga-Velazquez, J. C., Bekk, K., Bertaina, M., Bluemer, J., Bozdog, H., Brancus, I. M., Cantoni, E., Chiavassa, A., Cossavella, F., Curcio, C., Daumiller, K., de Souza, V., Di Pierro, F., Doll, P., Engel, R., Engler, J., Fuchs, B., Fuhrmann, D., Gils, H. J., Glasstetter, R., Grupen, C., Heck, D., Hoerandel, J. R., Huber, D., Huege, T., Kampert, K. -H., Kang, D., Klages, H. O., Link, K., Luczak, P., Ludwig, M., Mathes, H. J., Mayer, H. J., Melissas, M., Milke, J., Mitrica, B., Morello, C., Oehlschlaeger, J., Ostapchenko, S., Palmieri, N., Petcu, M., Pierog, T., Rebel, H., Roth, M., Schieler, H., Schoo, S., Schroeder, F. G., Sima, O., Toma, G., Trinchero, G. C., Ulrich, H., Weindl, A., Wochele, D., Wochele, J., and Collaboration, J. Zabierowski - KASCADE-Grande

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The detection of high-energy cosmic rays above a few hundred TeV is realized by the observation of extensive air-showers. By using the multi-detector setup of KASCADE-Grande, energy spectrum, elemental composition, and anisotropies of high-energy cosmic rays in the energy range from below the knee up to 2 EeV are investigated. In addition, the large high-quality data set permits distinct tests of the validity of hadronic interaction models used in interpreting air-shower measurements. After more than 16 years, the KASCADE-Grande experiment terminated measurements end of 2012. This contribution will give an overview of the main results of the data analysis achieved so far, and will report about the status of KCDC, the KASCADE Cosmic-ray Data Center, where via a web-based interface the data will be made available for the interested public., Comment: 4 pages, paper presented at the International Cosmic Ray Conference, Rio De Janeiro, 2013, paper ID 0300

Published
2013

15. Rate and Predictors of Unforeseen PN1/PN2-Disease in Surgically Treated cN0 NSCLC-Patients with Primary Tumor > 3 cm: Nationwide Results from Italian VATS-Group Database

Author

Lococo, Filippo, Nachira, D., Chiappetta, M., Sperduti, I., Congedo, Maria Teresa, Meacci, Elisa, Leoncini, F., Trisolini, Rocco, Crisci, R., Curcio, C., Casiraghi, M., Margaritora, Stefano, Lococo F. (ORCID:0000-0002-9383-5554), Congedo M. T., Meacci E. (ORCID:0000-0001-8424-3816), Trisolini R., Margaritora S. (ORCID:0000-0002-9796-760X), Lococo, Filippo, Nachira, D., Chiappetta, M., Sperduti, I., Congedo, Maria Teresa, Meacci, Elisa, Leoncini, F., Trisolini, Rocco, Crisci, R., Curcio, C., Casiraghi, M., Margaritora, Stefano, Lococo F. (ORCID:0000-0002-9383-5554), Congedo M. T., Meacci E. (ORCID:0000-0001-8424-3816), Trisolini R., and Margaritora S. (ORCID:0000-0002-9796-760X)

Abstract

Background. Since no robust data are available on the real rate of unforeseen N1-N2 disease (uN) and the relative predictive factors in clinical-N0 NSCLC with peripheral tumours > 3 cm, the usefulness of performing a (mini)invasive mediastinal staging in this setting is debated. Herein, we investigated these issues in a nationwide database. Methods. From 01/2014 to 06/2020, 15,784 thoracoscopic major lung resections were prospectively recorded in the “Italian VATS-Group” database. Among them, 1982 clinical-N0 peripheral solid-type NSCLC > 3 cm were identified, and information was retrospectively reviewed. A mean comparison of more than two groups was made by ANOVA (Bonferroni correction for multiple comparisons), while associations between the categorical variables were estimated with a Chi-square test. The multivariate logistic regression model and Kaplan–Meyer method were used to identify the independent predictors of nodal upstaging and survival results, respectively. Results. At pathological staging, 229 patients had N1-involvement (11.6%), and 169 had uN2 disease (8.5%). Independent predictors of uN1 were SUVmax (OR: 1.98; CI 95: 1.44–2.73, p = 0.0001) and tumour-size (OR: 1.52; CI: 1.11–2.10, p = 0.01), while independent predictors of uN2 were age (OR: 0.98; CI 95: 0.96–0.99, p = 0.039), histology (OR: 0.48; CI 95: 0.30–0.78, p = 0.003), SUVmax (OR: 2.07; CI 95: 1.15–3.72, p = 0.015), and the number of resected lymph nodes (OR: 1.03; CI 95: 1.01–1.05, p = 0.002). Conclusions. The unforeseen N1-N2 disease in cN0/NSCLCs > 3 cm undergoing VATS resection is observable in between 12 and 8% of all cases. We have identified predictors that could guide physicians in selecting the best candidate for (mini)invasive mediastinal staging.

Published
2023

17. Comparison of operative and postoperative characteristics and outcomes between thoracoscopic segmentectomy and lobectomy for non-small-cell lung cancer: a propensity score matching study from the Italian VATS Group Registry

Author

Dell'Amore, A., Lomangino, I., Cannone, G., Terzi, S., Pangoni, A., Lorenzoni, G., Nicotra, S., Schiavon, M., Zuin, A., Gregori, D., Crisci, R., Curcio, C., Rea, F., Mancuso, M., Pernazza, F., Refai, M., Bortolotti, L., Rizzardi, G., Solli, P., Brandolini, I., Perkmann, R., Zaraca, F., Benvenuti, M., Gavezzoli, D., Cherchi, R., Ferrari, P., Mucilli, F., Camplese, P., Melloni, G., Mazza, F., Cavallesco, G., Maniscalco, P., Voltolini, L., Gonfiotti, A., Stella, F., Argnani, D., Pariscenti, G. L., Iurilli, S., Surrente, C., Lopez, C., Droghett, A., Giovanardi, M., Breda, C., Lo Giudice, F., Alloisio, M., Bottoni, E., Spaggiari, L., Gasparri, R., Torre, M., Rinaldo, A., Nosotti, M., Rosso, L., Negri, G. P., Bandiera, A., Stefani, A., Natali, P., Scarci, M., Pirondini, E., Amore, D., Baietto, G., Casadio, C., Bertani, A., Russo, E., Ampollini, L., Carbognani, P., Puma, F., Vinci, D., Andreetti, C., Poggi, C., Cardillo, G., Margaritora, S., Meacci, E., Luzzi, L., Ghisalberti, M., Zaccagna, G., Lausi, P., Guerrera, F., Fontana, D., Della Beffa, V., Morelli, A., Londero, F., Imperatori, N., Rotolo, A., Terzi, A., Viti, A., Infante, M., and Benato, C.

Subjects
Segmentectomy, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Lung Neoplasms, medicine.medical_treatment, VATS lobectomy, Video-assisted thoracic surgery, Context (language use), Mastectomy, Segmental, Postoperative outcome, Postoperative Complications, Lobectomy, Non-small-cell lung cancer, Carcinoma, Non-Small-Cell Lung, Humans, Medicine, Registries, Thoracotomy, Pneumonectomy, Propensity Score, Lung cancer, Retrospective Studies, Thoracic Surgery, Video-Assisted, business.industry, Confounding, Postoperative complication, General Medicine, medicine.disease, Surgery, Propensity score matching, Non small cell, Cardiology and Cardiovascular Medicine, business
Abstract

OBJECTIVES Only few studies compared the surgical morbidity and mortality of thoracoscopic segmentectomy versus lobectomy for non-small-cell lung cancer, in particular, by relating the segmental resections with the corresponding anatomical lobes. METHODS We enrolled a total of 7487 patients who underwent VATS lobectomy (7269) or segmentectomy (218) from January 2014 to July 2019. A propensity score matching approach was used to account for potential confounding factors between the 2 groups. After matching, 349 lobectomies and 208 segmentectomies were included in the analysis. We analysed the operative and postoperative outcomes of video-assisted anatomical segmentectomy compared with video-assisted lobectomy and, in details, the results of segmentectomy with its corresponding lobectomy in a large cohort of patients from the Italian VATS Group Registry. RESULTS The overall conversion rate to thoracotomy was not statistically different between the groups (27 patients 8% vs 7 patients 3%, P = 0.1). The lobectomy group had a greater number of resected lymph nodes (median 11 vs 8, P = 0.006). No significant differences were detected in 30-day mortality (1.4%, 5 patients vs 0.9%, 2 patients), overall complications (18%, 62 patients vs 14%, 29 patients) and prolonged air leakage (31 patients, 9% vs 12 patients, 6%) between lobectomy and segmentectomy, respectively. No statistical differences were found regarding the median duration of drainage (3.2 days, P = 1) and the overall median length of hospital stay (6.4 days, P = 0.1) between the 2 groups. In the context of segmentectomy versus corresponding lobectomy, the right upper lobectomy compared with right upper segmentectomy showed a higher number of resected lymph nodes (P = 0.027). No statistical differences were reported in terms of conversion rate and postoperative complication and mortality. CONCLUSIONS Segmentectomy could be considered a safe procedure without significant differences compared to thoracoscopic lobectomy in terms of postoperative morbidity and mortality.

Published
2021

19. Latest results from the KASCADE-Grande experiment

Author

Chiavassa, A., Apel, W.D., Arteaga-Velázquez, J.C., Bekk, K., Bertaina, M., Blümer, J., Bozdog, H., Brancus, I.M., Cantoni, E., Cossavella, F., Curcio, C., Daumiller, K., de Souza, V., Di Pierro, F., Doll, P., Engel, R., Engler, J., Fuchs, B., Fuhrmann, D., Gils, H.J., Glasstetter, R., Grupen, C., Haungs, A., Heck, D., Hörandel, J.R., Huber, D., Huege, T., Kampert, K.-H., Kang, D., Klages, H.O., Link, K., Łuczak, P., Ludwig, M., Mathes, H.J., Mayer, H.J., Melissas, M., Milke, J., Mitrica, B., Morello, C., Oehlschläger, J., Ostapchenko, S., Palmieri, N., Petcu, M., Pierog, T., Rebel, H., Roth, M., Schieler, H., Schoo, S., Schröder, F.G., Sima, O., Toma, G., Trinchero, G.C., Ulrich, H., Weindl, A., Wochele, J., and Zabierowski, J.

Published
2014
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20. Phaseless, non-redundant planar wide-mesh scanning for antenna characterization: numerical validation

Author

Bevilacqua, F., Capozzoli, A., Curcio, C., D'Agostino, F., Ferrara, F., Gennarelli, C., Guerriero, R., Liseno, A., Migliozzi, M., Vardaxoglou, Y., Bevilacqua, F., Capozzoli, A., Curcio, C., D'Agostino, F., Ferrara, F., Gennarelli, C., Guerriero, R., Liseno, A., Migliozzi, M., and Vardaxoglou, Y.

Subjects
non-redundant sampling representations of electromagnetic fields, Phaseless near-field-far-field transformations, planar wide-mesh scanning, prolate spheroidal wave functions, Near-Field/Far-Field, Phaseless, Phase Retrieval, Non-Redundant Sampling, Planar, Wide-Mesh
Abstract

This paper aims to introduce a phaseless near-field-far-field (NF-FF) transformation with planar wide-mesh scanning (PWMS) and to give a numerical validation of the technique. The here considered NF-FF transformation, based on a non-redundant sampling representation of the electromagnetic field developed by modeling the antenna under test (AUT) with a double bowl, allows to achieve a remarkable reduction (about 90%) of needed NF samples, as compared to standard λ/4 sampling. The reliability and stability of the phase retrieval problem is improved exploiting a proper representation of the unknowns and the a priori information on the AUT. Numerical results, assessing the proposed characterization technique, are shown.

Published
2022

21. AI-aided holographic flow cytometry for label-free identification of ovarian cancer cells in the presence of unbalanced datasets.

Author

Borrelli, F., Behal, J., Cohen, A., Miccio, L., Memmolo, P., Kurelac, I., Capozzoli, A., Curcio, C., Liseno, A., Bianco, V., Shaked, N. T., and Ferraro, P.

Abstract

Liquid biopsy is a valuable emerging alternative to tissue biopsy with great potential in the noninvasive early diagnostics of cancer. Liquid biopsy based on single cell analysis can be a powerful approach to identify circulating tumor cells (CTCs) in the bloodstream and could provide new opportunities to be implemented in routine screening programs. Since CTCs are very rare, the accurate classification based on high-throughput and highly informative microscopy methods should minimize the false negative rates. Here, we show that holographic flow cytometry is a valuable instrument to obtain quantitative phase-contrast maps as input data for artificial intelligence (AI)-based classifiers. We tackle the problem of discriminating between A2780 ovarian cancer cells and THP1 monocyte cells based on the phase-contrast images obtained in flow cytometry mode. We compare conventional machine learning analysis and deep learning architectures in the non-ideal case of having a dataset with unbalanced populations for the AI training step. The results show the capacity of AI-aided holographic flow cytometry to discriminate between the two cell lines and highlight the important role played by the phase-contrast signature of the cells to guarantee accurate classification. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Experimental validation of a phaseless, non-redundant plane-polar antenna characterization

Author

Bevilacqua, F., Capozzoli, A., Curcio, C., D'Agostino, F., Ferrara, F., Gennarelli, C., Guerriero, R., Liseno, A., Migliozzi, M., Vardaxoglou, Y., Bevilacqua, Florindo, Capozzoli, Amedeo, Curcio, Claudio, D'Agostino, Francesco, Ferrara, Flaminio, Gennarelli, Claudio, Guerriero, Rocco, Liseno, Angelo, Migliozzi, Massimo, and Vardaxoglou, Yiannis

Subjects
Plane-polar scanning, Phaseless near-field-far-field transformations, Near-Field/Far-Field, Phaseless, plane-polar scanning, experimental measurements, Non-redundant sampling representations of electromagnetic fields, Prolate spheroidal wave functions, Antenna measurements
Abstract

Owing to the increasing interest in high frequencies, as the millimeter wave range, wherein accurate phase measurements are increasingly difficult and expensive, phaseless near-field techniques are prime candidates for antenna characterization. In this paper, an experimental validation of a phaseless near-field-far-field (NF -FF) transformation with plane-polar scanning for antenna characterization is presented. A proper representation of problem unknowns and data, using the available information on the antenna under test (AUT) and on the scanning geometry, is adopted in order to improve the reliability and the accuracy of the proposed characterization algorithm. By exploiting the nonredundant sampling representations of electromagnetic fields and by using an oblate spheroid to model the AUT, a remarkable reduction (about 90%) of the required NF samples is achieved. Experimental results on data acquired at the University of Salerno Antenna Characterization Lab are reported to validate experimentally the effectiveness of the proposed characterization technique.

Published
2021

27. What counts more: The patient, the surgical technique, or the hospital? A multivariable analysis of factors affecting perioperative complications of pulmonary lobectomy by video-assisted thoracoscopic surgery from a large nationwide registry

Author

Infante, Maurizio V, Benato, Cristiano, Silva, Ronaldo, Rocco, Gaetano, Bertani, Alessandro, Bertolaccini, Luca, Gonfiotti, Alessandro, Giovannetti, Riccardo, Bonadiman, Cinzia, Lonardoni, Alessandro, Canneto, Barbara, Falezza, Giovanni, Gandini, Paola, Curcio, Carlo, Crisci, Roberto, Alloisio, M, Amore, D, Ampollini, L, Andreetti, C, Argnani, D, Baietto, G, Bandiera, A, Benato, C, Benvenuti, M, Bertani, A, Bertolaccini, L, Bortolotti, L, Bottoni, E, Breda, C, Camplese, P, Carbognani, P, Cardillo, G, Casadio, C, Cavallesco, G, Cherchi, R, Crisci, R, Curcio, C, Dell'Amore, A, Beffa, V, Dolci, G, Droghetti, A, Ferrari, Pa, Fontana, D, Gargiulo, G, Gasparri, R, Gavezzoli, D, Ghisalberti, M, Giovanardi, M, Gonfiotti, A, Guerrera, F, Imperatori, A, Infante, M, Iurilli, L, Lausi, P, Logiudice, F, Londero, F, Lopez, C, Luzzi, L, Mancuso, M, Maniscalco, P, Margaritora, S, Meacci, E, Melloni, G, Morelli, A, Mucilli, F, Natali, P, Negri, G, Nicotra, S, Nosotti, M, Pariscenti, G, Perkmann, R, Pernazza, F, Pirondini, E, Poggi, C, Puma, F, Refai, M, Rinaldo, A, Rizzardi, G, Rosso, L, Rotolo, N, Russo, E, Sabbatini, A, Scarci, M, Spaggiari, L, Stefani, A, Solli, P, Surrente, C, Terzi, A, Torre, M, Vinci, D, Viti, A, Voltolini, L, Zaccagna, G, Zaraca, F., Infante M.V., Benato C., Silva R., Rocco G., Bertani A., Bertolaccini L., Gonfiotti A., Giovannetti R., Bonadiman C., Lonardoni A., Canneto B., Falezza G., Gandini P., Curcio C., Crisci R., Zaraca F., Alloisio M., Amore D., Ampollini L., Andreetti C., Argnani D., Baietto G., Bandiera A., Benvenuti M., Bortolotti L., Bottoni E., Breda C., Camplese P., Carbognani P., Cardillo G., Casadio C., Cavallesco G., Cherchi R., Dell'Amore A., Beffa V., Dolci G., Droghetti A., Ferrari P.A., Fontana D., Gargiulo G., Gasparri R., Gavezzoli D., Ghisalberti M., Giovanardi M., Guerrera F., Imperatori A., Iurilli L., Lausi P., Lo Giudice F., Londero F., Lopez C., Luzzi L., Mancuso M., Maniscalco P., Margaritora S., Meacci E., Melloni G., Morelli A., Mucilli F., Natali P., Negri G., Nicotra S., Nosotti M., Pariscenti G., Perkmann R., Pernazza F., Pirondini E., Poggi C., Puma F., Refai M., Rinaldo A., Rizzardi G., Rosso L., Rotolo N., Russo E., Sabbatini A., Scarci M., Spaggiari L., Stefani A., Solli P., Surrente C., Terzi A., Torre M., Vinci D., Viti A., Voltolini L., Zaccagna G., Infante, M. V., Benato, C., Silva, R., Rocco, G., Bertani, A., Bertolaccini, L., Gonfiotti, A., Giovannetti, R., Bonadiman, C., Lonardoni, A., Canneto, B., Falezza, G., Gandini, P., Curcio, C., Crisci, R., the Italian VATS group, Member, and Negri, G.

Subjects
Male, Registrie, Conversion, Morbidity, Postoperative complications, Video-assisted thoracoscopic surgery lobectomy, Lung Neoplasms, Intraoperative Complication, Aged, Female, Hospitals, Humans, Intraoperative Complications, Lung, Middle Aged, Pneumonectomy, Postoperative Complications, Registries, Retrospective Studies, Risk Factors, Thoracic Surgery, Video-Assisted, medicine.medical_treatment, Interquartile range, Retrospective Studie, Settore MED/21 - CHIRURGIA TORACICA, Conversion, Morbidity, Postoperative complications, Video-assisted thoracoscopic surgery lobectomy, Thoracic Surgery, General Medicine, Video-assisted thoracoscopic surgery, Cardiology and Cardiovascular Medicine, Human, Pulmonary and Respiratory Medicine, medicine.medical_specialty, VATS lobectomy, Video-Assisted, NO, Hospital, medicine, business.industry, Risk Factor, Retrospective cohort study, Perioperative, medicine.disease, Comorbidity, Surgery, Postoperative complication, Lung Neoplasm, Complication, business
Abstract

OBJECTIVESInherent technical aspects of pulmonary lobectomy by video-assisted thoracoscopic surgery (VATS) may limit surgeons’ ability to deal with factors predisposing to complications. We analysed complication rates after VATS lobectomy in a prospectively maintained nationwide registry.METHODSThe registry was queried for all consecutive VATS lobectomy procedures from 49 Italian Thoracic Units. Baseline condition, tumour features, surgical techniques, devices, postoperative care, complications, conversions and the reasons thereof were detailed. Univariable and multivariable regressions were used to assess factors potentially linked to complications.RESULTSFour thousand one hundred and ninety-one VATS lobectomies in 4156 patients (2480 men, 1676 women) were analysed. The median age-adjusted Charlson index of the patients was 4 (interquartile range 3–6). Grade 1 and 2 and Grade 3–5 complications were observed in 20.1% and in 5.8%, respectively. Ninety-day mortality was 0.55%. The overall conversion rate was 9.2% and significantly higher in low-volume centres (CONCLUSIONSVATS lobectomy is a safe procedure even in medically compromised patients. An improved classification system for conversions is proposed and prevention strategies are suggested to reduce conversion rates and possibly complications in less-experienced centres.

Published
2019

28. Uniportal and three-portal video-assisted thoracic surgery lobectomy: analysis of the Italian video-assisted thoracic surgery group database

Author

Tosi, D, Nosotti, M, Bonitta, G, Mazzucco, A, Righi, I, Mendogni, P, Rosso, L, Palleschi, A, Rocco, G, Crisci, R, Mancuso, M, Pernazza, F, Refai, M, Bortolotti, L, Rizzardi, G, Gargiulo, G, Dolci, Gp, Perkmann, R, Zaraca, F, Benvenuti, M, Gavezzoli, D, Cherchi, R, Ferrari, P, Mucilli, F, Camplese, P, Melloni, G, Mazza, F, Cavallesco, G, Maniscalco, P, Voltolini, L, Gonfiotti, A, Stella, F, Argnani, D, Pariscenti, Gl, Lurilli, Surrente, C, Lopez, C, Droghetti, A, Giovanardi, M, Breda, C, Lo Giudice, F, Alloisio, M, Bottoni, E, Spaggiari, L, Gasparri, R, Torre, M, Rinaldo, A, Negri, Gp, Bandiera, A, Stefani, A, Natali, P, Scarci, M, Pirondini, E, Curcio, C, Amore, D, Baietto, G, Casadio, C, Nicotra, S, Dell'Amore, A, Bertani, A, Russo, E, Ampollini, L, Carbognani, P, Puma, F, Vinci, D, Andreetti, C, Poggi, C, Cardillo, G, Margaritora, S, Meacci, Elisa, Luzzi, L, Ghisalberti, M, Zaccagna, G, Lausi, P, Guerrera, F, Fontana, D, Della Beffa, V, Morelli, A, Londero, F, Imperatori, A, Rotolo, N, Terzi, A, Viti, A, Infante, M, Benato, C, Tosi, D., Nosotti, M., Bonitta, G., Mazzucco, A., Righi, I., Mendogni, P., Rosso, L., Palleschi, A., Rocco, G., Crisci, R., Mancuso, M., Pernazza, F., Refai, M., Bortolotti, L., Rizzardi, G., Gargiulo, G., Dolci, G. P., Perkmann, R., Zaraca, F., Benvenuti, M., Gavezzoli, D., Cherchi, R., Ferrari, P., Mucilli, F., Camplese, P., Melloni, G., Mazza, F., Cavallesco, G., Maniscalco, P., Voltolini, L., Gonfiotti, A., Stella, F., Argnani, D., Pariscenti, G. L., Surrente, C., Lopez, C., Droghetti, A., Giovanardi, M., Breda, C., Lo Giudice, F., Alloisio, M., Bottoni, E., Spaggiari, L., Gasparri, R., Torre, M., Rinaldo, A., Negri, G, Bandiera, A., Stefani, A., Natali, P., Scarci, M., Pirondini, E., Curcio, C., Amore, D., Baietto, G., Casadio, C., Nicotra, S., Dell'Amore, A., Bertani, A., Russo, E., Ampollini, L., Carbognani, P., Puma, F., Vinci, D., Andreetti, C., Poggi, C., Cardillo, G., Margaritora, S., Meacci, E., Luzzi, L., Ghisalberti, M., Zaccagna, G., Lausi, P., Guerrera, F., Fontana, D., Della Beffa, V., Morelli, A., Londero, F., Imperatori, A., Rotolo, N., Terzi, A., Viti, A., Infante, M., Benato, C., Tosi D., Nosotti M., Bonitta G., Mazzucco A., Righi I., Mendogni P., Rosso L., Palleschi A., Rocco G., Crisci R., Mancuso M., Pernazza F., Refai M., Bortolotti L., Rizzardi G., Gargiulo G., Dolci G.P., Perkmann R., Zaraca F., Benvenuti M., Gavezzoli D., Cherchi R., Ferrari P., Mucilli F., Camplese P., Melloni G., Mazza F., Cavallesco G., Maniscalco P., Voltolini L., Gonfiotti A., Stella F., Argnani D., Pariscenti G.L., Surrente C., Lopez C., Droghetti A., Giovanardi M., Breda C., Lo Giudice F., Alloisio M., Bottoni E., Spaggiari L., Gasparri R., Torre M., Rinaldo A., Negri G.P., Bandiera A., Stefani A., Natali P., Scarci M., Pirondini E., Curcio C., Amore D., Baietto G., Casadio C., Nicotra S., Dell'amore A., Bertani A., Russo E., Ampollini L., Carbognani P., Puma F., Vinci D., Andreetti C., Poggi C., Cardillo G., Margaritora S., Meacci E., Luzzi L., Ghisalberti M., Zaccagna G., Lausi P., Guerrera F., Fontana D., Della Beffa V., Morelli A., Londero F., Imperatori A., Rotolo N., Terzi A., Viti A., Infante M., and Benato C.

Subjects
Male, Lung Neoplasms, Thoracic, Italian VATS Group, computer.software_genre, Postoperative pain, Settore MED/21 - CHIRURGIA TORACICA, Carcinoma, Non-Small-Cell Lung, Lobectomy, Three-portal, Uniportal, Video-assisted thoracic surgery, Aged, Equipment Design, Female, Humans, Neoplasm Staging, Operative Time, Pneumonectomy, Retrospective Studies, Thoracic Surgery, Video-Assisted, Tomography, X-Ray Computed, Stage (cooking), Non-Small-Cell Lung, Tomography, Database, Thoracic Surgery, X-Ray Computed, Cardiothoracic surgery, Cohort, Cardiology and Cardiovascular Medicine, Pulmonary and Respiratory Medicine, Italian VATS Group, Lobectomy, Postoperative pain, Three-portal, Uniportal, Video-assisted thoracic surgery, medicine.medical_specialty, VATS lobectomy, Video-Assisted, NO, medicine, Lung cancer, business.industry, Carcinoma, Odds ratio, medicine.disease, Confidence interval, Propensity score matching, Surgery, business, computer
Abstract

OBJECTIVES This study compares the uniportal with the 3-portal video-assisted thoracic surgery (VATS) by examining the data collected in the Italian VATS Group Database. The primary end point was early postoperative pain; secondary end points were intraoperative and postoperative complications, surgical time, number of dissected lymph nodes and length of stay. METHODS This was an observational, retrospective, cohort, multicentre study on data collected by 49 Italian thoracic units. Inclusion criteria were clinical stage I–II non-small-cell lung cancer, uniportal or 3-portal VATS lobectomy and R0 resection. Exclusion criteria were cT3 disease, previous thoracic malignancy, induction therapy, significant comorbidities and conversion to other techniques. The pain parameter was dichotomized: the numeric rating scale ≤3 described mild pain, whereas the numeric rating scale score >3 described moderate/severe pain. The propensity score-adjusted generalized estimating equation was used to compare the uniportal with 3-portal lobectomy. RESULTS Among 4338 patients enrolled from January 2014 to July 2017, 1980 met the inclusion criteria; 1808 patients underwent 3-portal lobectomy and 172 uniportal surgery. The adjusted generalized estimating equation regression model using the propensity score showed that over time pain decreased in both groups (P CONCLUSIONS Data from the Italian VATS Group Database showed that in clinical practice uniportal lobectomy seems to entail a higher risk of moderate/severe pain on second and third postoperative days.

Published
2019

30. Does morbid obesity influence perioperative outcomes after video-assisted thoracic surgery (VATS) lobectomy for non-small cell lung cancer? Analysis of the Italian VATS group registry

Author

Guerrera, F., Lyberis, P., Lausi, P. O., Cristofori, R. C., Giobbe, R., Molinatti, M., Filosso, P. L., Curcio, C., Crisci, R., Ruffini, E., Maurizio, M., Fausto, P., Majed, R., Franco, S., Desideria, A., Giuseppe, M., Angela, D. P., Luigi, B., Giovanna, R., Piergiorgio, S., Giampiero, D., Reinhold, P., Francesco, Z., Roberto, B. M., Diego, G., Roberto, C., Albino, F. P., Felice, M., Pierpaolo, C., Giulio, M., Federico, M., Giorgio, C., Pio, M., Luca, V., Alessandro, G., Francesco, S., Pia, A. N., Luca, P. G., Carlo, R., Corrado, S., Camillo, L., Andrea, D., Michele, G., Cristiano, B., Fabio, L. G., Marco, A., Edoardo, B., Lorenzo, S., Roberto, G., Massimo, T., Alessandro, R., Mario, N., Davide, T., Giampeiro, N., Alessandro, B., Federico, R., Alessandro, S., Pamela, N., Marco, S., Emanuele, P., Carlo, C., Dario, A., Ottavio, R., Samuele, N., Andrea, D. A., Giorgia, T., Luca, A., Paolo, C., Francesco, P., Damiano, V., Giuseppe, C., Francesco, C., Stefano, M., Elisa, M., Piero, P., Marco, G., Duilio, D., Diego, F., Vittorio, D. B., Angelo, M., Francesco, L., Andrea, I., Nicola, R., Alberto, Andrea, V., and Maurizio, I.

Subjects
medicine.medical_specialty, Surgical margin, Lung Neoplasms, medicine.medical_treatment, VATS lobectomy, Video-assisted thoracic surgery, Blood Loss, Surgical, Lobectomy, Lung Cancer, Morbidity, Mortality, Obesity, Postoperative Complications, Carcinoma, Non-Small-Cell Lung, medicine, Humans, Thoracotomy, Registries, Lung cancer, Pneumonectomy, Retrospective Studies, business.industry, Thoracic Surgery, Video-Assisted, Margins of Excision, Perioperative, Length of Stay, medicine.disease, Surgery, Obesity, Morbid, Chest tube, Treatment Outcome, Cardiothoracic surgery, business, Abdominal surgery
Abstract

Objectives Obesity in Europe, and worldwide, has been an increasing epidemic during the past decades. Moreover, obesity has important implications regarding technical issues and the risks associated with surgical interventions. Nevertheless, there is a lack of evidence assessing the influence of obesity on video-assisted thoracic surgery (VATS) lobectomy results. Our study aimed to assess the impact of morbid obesity on perioperative clinical and oncological outcomes after VATS lobectomy using a prospectively maintained nationwide registry. Methods The Italian VATS lobectomy Registry was used to collect all consecutive cases from 55 Institutions. Explored outcome parameters were conversion to thoracotomy rates, complication rates, intra-operative blood loss, surgical time, hospital postoperative length of stay, chest tube duration, number of harvested lymph-node, and surgical margin positivity. Results From 2016 to 2019, a total of 4412 patients were collected. 74 patients present morbid obesity (1.7%). Multivariable-adjusted analysis showed that morbid obesity was associated with a higher rate of complications (32.8% vs 20.3%), but it was not associated with a higher rate of conversion, and surgical margin positivity rates. Moreover, morbid obesity patients benefit from an equivalent surgical time, lymph-node retrieval, intraoperative blood loss, hospital postoperative length of stay, and chest tube duration than non-morbid obese patients. The most frequent postoperative complications in morbidly obese patients were pulmonary-related (35%). Conclusion Our results showed that VATS lobectomy could be safely and satisfactorily conducted even in morbidly obese patients, without an increase in conversion rate, blood loss, surgical time, hospital postoperative length of stay, and chest tube duration. Moreover, short-term oncological outcomes were preserved.

Published
2021

31. Enhanced expression of mir-181b in b cells of cll improves the anti-tumor cytotoxic t cell response

Author

Di Marco, M., Veschi, S., Lanuti, P., Ramassone, A., Pacillo, S., Pagotto, S., Pepe, F., George-William, J. N., Curcio, C., Marchisio, M., Miscia, S., Innocenti, Idanna, Autore, Francesco, Vannata, B., Di Gregorio, P., Di Gioacchino, M., Valentinuzzi, S., Iezzi, Martina, Mariani-Costantini, R., Larocca, Luigi Maria, Laurenti, Luca, Veronese, A., Visone, R., Innocenti I., Autore F., Iezzi M., Larocca L. M. (ORCID:0000-0003-1739-4758), Laurenti L. (ORCID:0000-0002-8327-1396), Di Marco, M., Veschi, S., Lanuti, P., Ramassone, A., Pacillo, S., Pagotto, S., Pepe, F., George-William, J. N., Curcio, C., Marchisio, M., Miscia, S., Innocenti, Idanna, Autore, Francesco, Vannata, B., Di Gregorio, P., Di Gioacchino, M., Valentinuzzi, S., Iezzi, Martina, Mariani-Costantini, R., Larocca, Luigi Maria, Laurenti, Luca, Veronese, A., Visone, R., Innocenti I., Autore F., Iezzi M., Larocca L. M. (ORCID:0000-0003-1739-4758), and Laurenti L. (ORCID:0000-0002-8327-1396)

Abstract

The clinical progression of B cell chronic lymphocytic leukemia (CLL) is associated with immune cell dysfunction and a strong decrease of miR-181b-5p (miR-181b), promoting the death of CLL cells. Here we investigated whether the reduction of miR-181b impairs the immune response in CLL. We demonstrate that activated CD4+ T cells increase miR-181b expression in CLL through CD40– CD40L signaling, which enhances the maturation and activity of cytotoxic T cells and, consequently, the apoptotic response of CLL cells. The cytotoxic response is facilitated by a depletion of the anti-inflammatory cytokine interleukin 10, targeted by miR-181b. In vivo experiments in NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ mice confirmed that miR-181b promotes the apoptotic death of CLL cells only when functional T cells are restored. Overall, our findings suggest that the reinstatement of miR-181b in CLL cells could be an exploitable adjuvant therapeutic option for the treatment of CLL.

Published
2021

32. An Effective Phaseless NF Antenna Measurement Approach

Author

Capozzoli A., Curcio C., D'Elia G., Liseno A., IEEE, Capozzoli, A., Curcio, C., D'Elia, G., and Liseno, A.

Subjects
Planar scanning, Phaseless Near-Field/Far-Field transformation, Prolate Spheroidal Wave Functions
Abstract

Recently, a phaseless near-field antenna characterization approach has been proposed. It exploits an "effective" representation of the unknowns, able to reduce the overall number of parameters to be sought for and with signicant beneficial effects on both accuracy and reliability. At the same time, on taking advantage of the a priori information on the scanning geometry through a non-uniform sampling of the near-field, beneficial effects are obtained on the stability of the inversion process, on the rejection of the environmental clutter and on significantly reducing the overall number of near-field phaseless measurements to be performed.Experimental results at 75 and 94GHz concerning the near-field phaseless characterization of millimetre-wave antennas are presented. The results results show the feasibility of phaseless antenna characterization also in the millimetre frequency range. The aim of this paper is to numerically point out the accuracy and reliability of the proposed algorithm, with particular reference to millimeter-wave applications

Published
2019

33. Sub-Array Clustering for Reconfigurable Reflectarrays with a Reduced Control Complexity

Author

Capozzoli A., Curcio C., D'Elia G., Liseno A., Capozzoli, A., Curcio, C., D'Elia, G., and Liseno, A.

Subjects
synthesis, sub-array, reflectarray
Abstract

A method for the synthesis of reconfigurable reflectarray antennas with sub-array clustering is here presented. The approach is made up by two stages: an aperture synthesis devoted to the determination of the optimal clustering, common to all the beam configurations, and a reflectarray synthesis wherein the reflecting element belonging to the same cluster are driven with the same command phase.

Published
2019

35. Predictors of nodal upstaging in patients with cT1-3N0 non-small cell lung cancer (NSCLC): results from the Italian VATS Group Registry

Author

Marulli, G., Faccioli, E., Mammana, M., Nicotra, S., Comacchio, G., Verderi, E., De Palma, A., Curcio, C., Rea, F., Bertani, A., Russo, E., Voltolini, L., Gonfiotti, A., Nosotti, M., Rosso, L., Muriana, G., Droghetti, A., Crisci, R., Zaccagna, G., Amore, D., di Rienzo, G., Lopez, C., Morelli, A., Londero, F., Spaggiari, L., Gasparri, R., Baietto, G., Casadio, C., Infante, M., Benato, C, Alloisio, M., Bottoni, E, Cardillo, G., Carleo, F., Stella, F., Dolci, G., Puma, F., Vinci, D., Cavallesco, G., Maniscalco, P., Ampollini, L., Carbognani, P., Terzi, A., Viti, A, Negri, G., Bandiera, A., Perkmann, R., Zaraca, F., Andreetti, C., Poggi, C., Mucilli, F., Camplese, P., Luzzi, L., Ghisalberti, M., Imperatori, A., Rotolo, N., Bortolotti, L., Rizzardi, G., Torre, M., Rinaldo, A., Sabbatini, A., Refai, M., Benvenuti, M. R., Benetti, D., Stefani, A., Natali, P., Lausi, P., Guerrera, F., Melloni, G., Mazza, F., Argnani, D., Sanna, S., Fontana, D., Beffa, V. D., Meda, S., Pernazza, F. a, and Italian VATS Group

Subjects
Oncology, Male, Lung Neoplasms, medicine.medical_treatment, non-small cell lung cancer (NSCLC), Nodal upstaging, VATS lobectomy, 0302 clinical medicine, Risk Factors, Carcinoma, Non-Small-Cell Lung, 80 and over, Registries, Non-Small-Cell Lung, Child, Pneumonectomy, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Aged, 80 and over, Thoracic Surgery, Video-Assisted, Thoracic Surgery, General Medicine, Middle Aged, Lymph node dissection, Mediastinal staging, Predictive risk factors, Adolescent, Adult, Aged, Disease Progression, Female, Humans, Italy, Lymph Node Excision, Neoplasm Staging, Predictive Value of Tests, Young Adult, 030220 oncology & carcinogenesis, Predictive value of tests, 030211 gastroenterology & hepatology, Lymph node dissection, Mediastinal staging, Nodal upstaging, Predictive risk factors, VATS lobectomy, medicine.medical_specialty, Video-Assisted, NO, 03 medical and health sciences, Internal medicine, medicine, In patient, business.industry, Disease progression, Carcinoma, medicine.disease, Surgery, Neoplasm staging, business
Abstract

Accurate staging of early non-small cell lung cancer is fundamental for selecting the best treatment. The aim of this study was to identify risk factors for nodal upstaging after video-assisted thoracoscopic lobectomy for clinical T1-3N0 tumors.From 2014 to 2017, 3276 thoracoscopic lobectomies were recorded in the prospective database "Italian VATS Group". Linear and multiple logistic regression models were adapted to identify independent predictors of nodal upstaging and factors associated with progression in postoperative N status.Nodal upstaging was found in 417 cases (12.7%), including 206 cases (6.2%) of N1-positive nodes, 81 cases of N2 nodes (2.4%), and 130 cases (4%) of involvement of both N1 + N2 nodes. A total of 241 (7.3%) patients had single-station nodal involvement, whereas 176 (5.3%) had multiple-station involvement. In the final regression model, the tumor grade, histology, pathologic T status, and 12 resected nodes were independent predictors of nodal upstaging.The number of resected lymph nodes seems to predict nodal upstaging better than the type of intraoperative lymph node management. Other preoperative risk factors correspond to those for which the current guidelines of the European Society of Thoracic Surgery recommend more extensive preoperative mediastinal staging.

Published
2020

36. Correction to: Predictors of nodal upstaging in patients with cT1-3N0 non-small cell lung cancer (NSCLC): results from the Italian VATS Group Registry (Surgery Today, (2020), 50, 7, (711-718), 10.1007/s00595-019-01939-x)

Author

Marulli, G., Faccioli, E., Mammana, M., Nicotra, S., Comacchio, G., Verderi, E., De Palma, A., Curcio, C., Rea, F., Bertani, A., Russo, E., Voltolini, L., Gonfiotti, A., Nosotti, M., Rosso, L., Muriana, G., Droghetti, A., Crisci, R., Zaccagna, G., Amore, D., di Rienzo, G., Lopez, C., Morelli, A., Londero, F., Spaggiari, L., Gasparri, R., Baietto, G., Casadio, C., Infante, M., Benato, C., Alloisio, M., Bottoni, E., Cardillo, G., Carleo, F., Stella, F., Dolci, G., Puma, F., Vinci, D., Cavallesco, G., Maniscalco, P., Ampollini, L., Carbognani, P., Terzi, A., Viti, A., Negri, G., Bandiera, A., Perkmann, R., Zaraca, F., Andreetti, C., Poggi, C., Mucilli, F., Camplese, P., Luzzi, L., Ghisalberti, M., Imperatori, A., Rotolo, N., Bortolotti, L., Rizzardi, G., Torre, M., Rinaldo, A., Sabbatini, A., Refai, M., Benvenuti, M. R., Benetti, D., Stefani, A., Natali, P., Lausi, P., Guerrera, F., Melloni, G., Mazza, F., Argnani, D., Sanna, S., Fontana, D., Beffa, V. D., Meda, S., and Pernazza, F.

Subjects
NO
Published
2020

37. Predicting a Prolonged Air Leak After Video-Assisted Thoracic Surgery, Is It Really Possible?

Author

Zaraca, Francesco, primary, Pipitone, Marco, additional, Feil, Birgit, additional, Perkmann, Reinhold, additional, Bertolaccini, Luca, additional, Curcio, Carlo, additional, Crisci, Roberto, additional, Mancuso, M., additional, Pernazza, F., additional, Refai, M., additional, Srella, F., additional, Argnani, D., additional, Marulli, G., additional, De Palma, A., additional, Bortolotti, L., additional, Rizzardi, G., additional, Solli, P.G., additional, Dolci, G.P., additional, Perkmann, R., additional, Zaraca, F., additional, Benvenuti, M., additional, Gavezzoli, D., additional, Cherchi, R., additional, Ferrari, P., additional, Mucilli, F., additional, Camplese, P., additional, Melloni, G., additional, Mazza, F., additional, Cavallesco, G., additional, Maniscalco, P., additional, Voltolini, L., additional, Gonfiotti, A., additional, Sollitto, F., additional, Ardò, N., additional, Pariscenti, G.L., additional, Risso, C., additional, Surrente, C., additional, Lopez, C., additional, Droghetti, A., additional, Giovanardi, M., additional, Breda, C., additional, Giudice, Lo F., additional, Alloisio, M., additional, Bottoni, E., additional, Spaggiari, L., additional, Gasparri, R., additional, Torre, M., additional, Rinaldo, A., additional, Nosotti, M., additional, Tosi, D., additional, Negri, G.P., additional, Bandiera, A., additional, Baisi, A., additional, Raveglia, F., additional, Stefani, A., additional, Natali, P., additional, Scarci, M., additional, Pirondini, E., additional, Curcio, C., additional, Amore, D., additional, Rena, O., additional, Nicotra, S., additional, Dell’ Amore, A., additional, Bertani, A., additional, Tancredi, G., additional, Ampollini, L., additional, Carbognani, P., additional, Puma, F., additional, Vinci, D., additional, Cardillo, G., additional, Carleo, F., additional, Margaritora, S., additional, Meacci, E., additional, Luzzi, L., additional, Ghisalberti, M., additional, Crisci, R., additional, Divisi, D., additional, Lausi, P., additional, Guerrera, F., additional, Fontana, D., additional, Beffa, V. Della, additional, Morelli, A., additional, Londero, F., additional, Imperatori, A., additional, Rotolo, N., additional, Terzi, A., additional, Viti, A., additional, Infante, M., additional, and Benato, C., additional

Published
2021
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38. The 〈 ln A 〉 study with the Muon tracking detector in the KASCADE-Grande experiment – comparison of hadronic interaction models

Author

Łuczak P., Apel W.D., Arteaga-Velázquez J.C., Bekk K., Bertaina M., Blümer J., Bozdog H., Brancus I.M., Cantoni E., Chiavassa A., Cossavella F., Curcio C., Daumiller K., Souza V. de, Pierro F. Di, Doll P., Engel R., Engler J., Fuchs B., Fuhrmann D., Gils H.J., Glasstetter R., Grupen C., Haungs A., Heck D., Hörandel J.R., Huber D., Huege T., Kampert K.-H., Kang D., Klages H.O., Link K., Ludwig M., Mathes H.J., Mayer H.J., Melissas M., Milke J., Mitrica B., Morello C., Oehlschläger J., Ostapchenko S., Palmieri N., Petcu M., Pierog T., Rebel H., Roth M., Schieler H., Schoo S., Schröder F.G., Sima O., Toma G., Trinchero G.C., Ulrich H., Weindl A., Wochele J., and Zabierowski J.

Subjects
Physics, QC1-999
Abstract

With the KASCADE-Grande Muon Tracking Detector it was possible to measure with high accuracy directions of EAS muons with energy above 0.8 GeV and up to 700 m distance from the shower centre. Reconstructed muon tracks allow investigation of muon pseudorapidity (η) distributions. These distributions are nearly identical to the pseudorapidity distributions of their parent mesons produced in hadronic interactions. Comparison of the η distributions from measured and simulated showers can be used to test the quality of the high energy hadronic interaction models. The pseudorapidity distributions reflect the longitudinal development of EAS and, as such, are sensitive to the mass of the cosmic ray primary particles. With various parameters of the η distribution, obtained from the Muon Tracking Detector data, it is possible to calculate the average logarithm of mass of the primary cosmic ray particles. The results of the 〈 ln A 〉 analysis in the primary energy range 1016 eV–1017 eV with the 1st quartile and the mean value of the distributions will be presented for the QGSJet-II-2, QGSJet-II-4, EPOS 1.99 and EPOS LHC models in combination with the FLUKA model.

Published
2015
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41. National adoption of video-assisted thoracoscopic surgery (VATS) lobectomy: The Italian VATS register evaluation

Author

Divisi D., Bertolaccini L., Barone M., Amore D., Argnani D., Zaccagna G., Solli P., Di Rienzo G., Curcio C., Crisci R., Ampollini L., Alloisio M., Andreetti C., Baietto G., Bandiera A., Benato C., Benetti D., Benvenuti M., Bertani A., Bortolotti L., Bottoni E., Camplese P., Carbognani P., Cardillo G., Carleo F., Casadio C., Cavallesco G., Negri A. D., Dolci G., Droghetti A., Gasparri R., Ghisalberti M., Gonfiotti A., Guerrera F., Imperatori A., Infante M., Lausi P., Londero F., Lopez C., Luzzi L., Maineri P., Maniscalco P., Marulli G., Monteverde M., Morelli A., Mucilli F., Natali P., Negri G., Nicotra S., Nosotti M., Perkmann R., Poggi C., Puma F., Refai M., Rinaldo A., Rizzardi G., Rosso L., Rotolo N., Russo E., Sabatini A., Spaggiari L., Stefani A., Stella F., Terzi A., Torre M., Vinci D., Viti A., Voltolini L., Zaraca F., Divisi D., Bertolaccini L., Barone M., Amore D., Argnani D., Zaccagna G., Solli P., Di Rienzo G., Curcio C., Crisci R., Ampollini L., Alloisio M., Andreetti C., Baietto G., Bandiera A., Benato C., Benetti D., Benvenuti M., Bertani A., Bortolotti L., Bottoni E., Camplese P., Carbognani P., Cardillo G., Carleo F., Casadio C., Cavallesco G., Negri A.D., Dolci G., Droghetti A., Gasparri R., Ghisalberti M., Gonfiotti A., Guerrera F., Imperatori A., Infante M., Lausi P., Londero F., Lopez C., Luzzi L., Maineri P., Maniscalco P., Marulli G., Monteverde M., Morelli A., Mucilli F., Natali P., Negri G., Nicotra S., Nosotti M., Perkmann R., Poggi C., Puma F., Refai M., Rinaldo A., Rizzardi G., Rosso L., Rotolo N., Russo E., Sabatini A., Spaggiari L., Stefani A., Stella F., Terzi A., Torre M., Vinci D., Viti A., Voltolini L., Zaraca F., Divisi, Duilio, Bertolaccini, Luca, Barone, Mirko, Amore, Dario, Argnani, Desideria, Zaccagna, Gino, Solli, Piergiorgio, Di Rienzo, Gaetano, Curcio, Carlo, Crisci, Roberto, Italian VATS, Group, and Negri, G

Subjects
Database, Learning curve, Learning tools, Non-small cell lung cancer, Training, Video-assisted thoracoscopic surgery lobectomy (VATS lobectomy), Pulmonary and Respiratory Medicine, medicine.medical_specialty, medicine.medical_treatment, VATS lobectomy, Air leak, NO, 03 medical and health sciences, 0302 clinical medicine, Learning tool, database, learning curve, learning tools, non-small cell lung cancer, training, medicine, Thoracotomy, business.industry, General surgery, Database, Learning curve, Learning tools, Non-small cell lung cancer, Training, Video-assisted thoracoscopic surgery lobectomy (VATS lobectomy), 030228 respiratory system, Cardiothoracic surgery, 030220 oncology & carcinogenesis, Video-assisted thoracoscopic surgery, Operative time, Original Article, business
Abstract

Background: The expertise curve of video-assisted thoracoscopic surgery (VATS) lobectomies still stirs debate and controversy both because of the number of procedures to carry out and of the evaluation of the learning threshold. The purpose of our study was the examination of the variables related to the learning curve of the video-assisted approach, to establish what may be an expression of the technical maturity of the surgeon. Methods: The National Register for VATS lobectomy built in 2013 was used to collect data from 65 Thoracic Surgery Units. Out of more than 3,700 patients enrolled, only information from Units with ≥100 VATS lobectomies were retrospectively analysed. Unpaired Student’s t-tests, Fisher’s exact tests, Pearson’s χ 2 were applied as needed. Cumulative summative analysis and one-way ANOVA were used to identify the expertise curve of VATS lobectomy. Results: Ten institutions contributed a total of 1,679 patients, who were divided into three uniform groups according to the chronological sequence of surgery. The length of utility incision, the number of dissected lymph nodes and the operative time were not statistically significant (P=0.999, P=0.972 and P=0.307, respectively) among groups. Conversion to thoracotomy and postoperative air leaks occurred in 125 (7.44%) and 109 (6.49%) patients, gradually declined in Group 3 with statistical signi cance (P=0.048 and P=0.00086). Conclusions: The conversion rate and the percentage of air leaks seem to de ne the expertise of VATS lobectomy, being linked to the ability to manage more complicated surgical cases or intraoperative adverse events.

Published
2018

42. Corrigendum to: What counts more: The patient, the surgical technique, or the hospital? A multivariable analysis of factors affecting perioperative complications of pulmonary lobectomy by video-assisted thoracoscopic surgery from a large nationwide registry (European Journal of Cardio-thoracic Surgery (2019) DOI: 10.1093/ejcts/ezz187)

Author

Infante, M. V., Benato, C., Silva, R., Rocco, G., Bertani, A., Bertolaccini, L., Gonfiotti, A., Giovannetti, R., Bonadiman, C., Lonardoni, A., Canneto, B., Falezza, G., Gandini, P., Curcio, C., Crisci, R., Zaraca, F., Alloisio, M., Amore, D., Ampollini, L., Andreetti, C., Argnani, D., Baietto, G., Bandiera, A., Benvenuti, M., Bortolotti, L., Bottoni, E., Breda, C., Camplese, P., Carbognani, P., Cardillo, G., Casadio, C., Cavallesco, G., Cherchi, R., Dell'Amore, A., Beffa, V., Dolci, G, Droghetti, A, Ferrari, P. A., Fontana, D., Gargiulo, G., Gasparri, R., Gavezzoli, D., Ghisalberti, M., Giovanardi, M., Guerrera, F., Imperatori, A., Iurilli, L., Lausi, P., Lo Giudice, F., Londero, F., Lopez, C., Luzzi, L., Mancuso, M., Maniscalco, P., Margaritora, S., Meacci, E., Melloni, G., Morelli, A., Mucilli, F., Natali, P., Negri, G., Nicotra, S., Nosotti, M., Pariscenti, G., Perkmann, R., Pernazza, F., Pirondini, E., Poggi, C., Puma, F., Refai, M., Rinaldo, A., Rizzardi, G, Rosso, L., Rotolo, N., Russo, E., Sabbatini, A., Scarci, M., Spaggiari, L., Stefani, A., Solli, P., Surrente, C., Terzi, A., Torre, M., Vinci, D., Viti, A., Voltolini, L., Zaccagna, G., and the Italian VATS group members

Subjects
Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Lung Neoplasms, Thoracic, medicine.medical_treatment, MEDLINE, NO, Postoperative Complications, Risk Factors, Pulmonary lobectomy, Humans, Medicine, Registries, Intraoperative Complications, Pneumonectomy, Lung, Aged, Retrospective Studies, Thoracic Surgery, Video-Assisted, business.industry, General surgery, General Medicine, Perioperative, Middle Aged, Corrigenda, Hospitals, Video-assisted thoracoscopic surgery, Female, Surgery, Cardiology and Cardiovascular Medicine, business
Abstract

OBJECTIVES: Inherent technical aspects of pulmonary lobectomy by video-assisted thoracoscopic surgery (VATS) may limit surgeons’ ability to deal with factors predisposing to complications. We analysed complication rates after VATS lobectomy in a prospectively maintained nationwide registry. METHODS: The registry was queried for all consecutive VATS lobectomy procedures from 49 Italian Thoracic Units. Baseline condition, tumour features, surgical techniques, devices, postoperative care, complications, conversions and the reasons thereof were detailed. Univariable and multivariable regressions were used to assess factors potentially linked to complications. RESULTS: Four thousand one hundred and ninety-one VATS lobectomies in 4156 patients (2480 men, 1676 women) were analysed. The median age-adjusted Charlson index of the patients was 4 (interquartile range 3–6). Grade 1 and 2 and Grade 3–5 complications were observed in 20.1% and in 5.8%, respectively. Ninety-day mortality was 0.55%. The overall conversion rate was 9.2% and significantly higher in low-volume centres (

Published
2019

43. Letter to the Editor

Author

Huo, Y. R., Suriyaarachchi, P., Gomez, F., Curcio, C. L., Boersma, D., Gunawardene, P., Demontiero, O., and Duque, G.

Published
2016
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45. Effects of the falls and fractures clinic as an integrated multidisciplinary model of care in Australia: a pre-post study

Author

Gomez, F, Lucia Curcio, C, Brennan-Olsen, SL, Boersma, D, Phu, S, Vogrin, S, Suriyaarachchi, P, Duque, G, Gomez, F, Lucia Curcio, C, Brennan-Olsen, SL, Boersma, D, Phu, S, Vogrin, S, Suriyaarachchi, P, and Duque, G

Abstract

OBJECTIVES: Traditionally, the approach to fracture prevention has focused on increasing bone mineral density while typically lacking a combined clinical approach to falls prevention and vice versa. To resolve this gap, we implemented and evaluated a novel combined model of care to the assessment and prevention of osteoporosis and falls in the outpatients setting. SETTING: Falls and Fractures Clinic (FFC) at Nepean Hospital (Penrith, NSW, Australia). PARTICIPANTS: Pre-effects and posteffects assessment of 106 community-dwelling older patients referred from the community. PRIMARY AND SECONDARY OUTCOME MEASURES: Previous falls and fractures were recorded. Clinical, functional and paraclinical evaluations were performed. A comprehensive multidisciplinary care plan was then tailored based on the presence of risk factors. Six-month follow-ups were performed assessing the incidence of falls and fractures, change in risk factors for falls and level of risk, with the recommended plan. RESULTS: We report that 97% of patients had a fall in the preceding 6 months, 47.6% of whom experienced a fracture from the fall. Furthermore, 64% of patients had a marked risk for falling by Physiological Profile Assessment (PPA), 90% had intermediate-high 10-year probability of fracture according to FRAX and 78% had sarcopenia. At 6-month follow-up, we observed more than an 80% reduction in falls and recurrent falls, and 50% reduction in fractures. In addition, 65% of patients had reduced PPA and a 57% reduction in 10-year fracture probability. CONCLUSIONS: In conclusion, we suggest that a multidisciplinary FFC can provide substantial reductions in falls and fractures for high-risk older people, even over a relatively short 6-month time period. The current model of service provision via traditional falls clinics could be significantly improved by encompassing fracture prevention within the multifactorial approach to interventions.

Published
2019

46. What counts more: the patient, the surgical technique, or the hospital? A multivariable analysis of factors affecting perioperative complications of pulmonary lobectomy by video-assisted thoracoscopic surgery from a large nationwide registry

Author

Infante, Mv, Benato, C, Silva, R, Rocco, G, Bertani, A, Bertolaccini, L, Gonfiotti, A, Giovannetti, R, Bonadiman, C, Lonardoni, A, Canneto, B, Falezza, G, Gandini, P, Curcio, C, Crisci, R, Alloisio, M, Amore, D, Ampollini, L, Andreetti, C, Argnani, D, Baietto, G, Bandiera, A, Benvenuti, Mr, Bortolotti, L, Bottoni, E, Breda, C, Camplese, P, Carbognani, P, Cardillo, G, Casadio, C, Cavallesco, G, Cherchi, R, Dell'Amore, A, Della Beffa, V, Dolci, G, Droghetti, A, Ferrari, Pa, Fontana, D, Gargiulo, G, Gasparri, R, Gavezzoli, D, Ghisalberti, M, Giovanardi, M, Guerrera, F, Imperatori, A, Infante, M, Iurilli, L, Lausi, P, Lo Giudice, F, Londero, F, Lopez, C, Luzzi, L, Mancuso, M, Maniscalco, P, Margaritora, Stefano, Meacci, Elisa, Melloni, G, Morelli, A, Mucilli, F, Natali, P, Negri, G, Nicotra, S, Nosotti, M, Pariscenti, G, Perkmann, R, Pernazza, F, Pirondini, E, Poggi, C, Puma, F, Refai, M, Rinaldo, A, Rizzardi, G, Rosso, L, Rotolo, N, Russo, E, Sabbatini, A, Scarci, M, Spaggiari, L, Stefani, A, Solli, P, Surrente, C, Terzi, A, Torre, M, Vinci, D, Viti, A, Voltolini, L, Zaccagna, G, Zaraca, F, Margaritora, S (ORCID:0000-0002-9796-760X), Meacci, E (ORCID:0000-0001-8424-3816), Infante, Mv, Benato, C, Silva, R, Rocco, G, Bertani, A, Bertolaccini, L, Gonfiotti, A, Giovannetti, R, Bonadiman, C, Lonardoni, A, Canneto, B, Falezza, G, Gandini, P, Curcio, C, Crisci, R, Alloisio, M, Amore, D, Ampollini, L, Andreetti, C, Argnani, D, Baietto, G, Bandiera, A, Benvenuti, Mr, Bortolotti, L, Bottoni, E, Breda, C, Camplese, P, Carbognani, P, Cardillo, G, Casadio, C, Cavallesco, G, Cherchi, R, Dell'Amore, A, Della Beffa, V, Dolci, G, Droghetti, A, Ferrari, Pa, Fontana, D, Gargiulo, G, Gasparri, R, Gavezzoli, D, Ghisalberti, M, Giovanardi, M, Guerrera, F, Imperatori, A, Infante, M, Iurilli, L, Lausi, P, Lo Giudice, F, Londero, F, Lopez, C, Luzzi, L, Mancuso, M, Maniscalco, P, Margaritora, Stefano, Meacci, Elisa, Melloni, G, Morelli, A, Mucilli, F, Natali, P, Negri, G, Nicotra, S, Nosotti, M, Pariscenti, G, Perkmann, R, Pernazza, F, Pirondini, E, Poggi, C, Puma, F, Refai, M, Rinaldo, A, Rizzardi, G, Rosso, L, Rotolo, N, Russo, E, Sabbatini, A, Scarci, M, Spaggiari, L, Stefani, A, Solli, P, Surrente, C, Terzi, A, Torre, M, Vinci, D, Viti, A, Voltolini, L, Zaccagna, G, Zaraca, F, Margaritora, S (ORCID:0000-0002-9796-760X), and Meacci, E (ORCID:0000-0001-8424-3816)

Abstract

OBJECTIVES: Inherent technical aspects of pulmonary lobectomy by video-assisted thoracoscopic surgery (VATS) may limit surgeons' ability to deal with factors predisposing to complications. We analysed complication rates after VATS lobectomy in a prospectively maintained nationwide registry.METHODS: The registry was queried for all consecutive VATS lobectomy procedures from 49 Italian Thoracic Units. Baseline condition, tumour features, surgical techniques, devices, postoperative care, complications, conversions and the reasons thereof were detailed. Univariable and multivariable regressions were used to assess factors potentially linked to complications.RESULTS: Four thousand one hundred and ninety-one VATS lobectomies in 4156 patients (2480 men, 1676 women) were analysed. The median age-adjusted Charlson index of the patients was 4 (interquartile range 3-6). Grade 1 and 2 and Grade 3-5 complications were observed in 20.1% and in 5.8%, respectively. Ninety-day mortality was 0.55%. The overall conversion rate was 9.2% and significantly higher in low-volume centres (<100 cases, P < 0.001), but there was no significant difference between intermediate- and high-volume centres under this aspect. Low-volume centres were significantly more likely to convert due to issues with difficult local anatomy, but not significantly so for bleeding. Conversion, lower case-volume, comorbidity burden, male gender, adhesions, blood loss, operative time, sealants and epidural analgesia were significantly associated with increased postoperative morbidity.CONCLUSIONS: VATS lobectomy is a safe procedure even in medically compromised patients. An improved classification system for conversions is proposed and prevention strategies are suggested to reduce conversion rates and possibly complications in less-experienced centres.

Published
2019

49. EFFECT OF THREE INTERVENTION PROGRAMS ON FEAR OF FALLING AND FUNCTIONALITY: A RANDOMIZED CONTROLLED TRIAL

Author

Curcio, C, Dueñas, E, Ponce, E, and Ramirez, L

Subjects
Abstracts
Abstract

Fear of falling (FoF) and reduction in physical functioning is common among older people. The objective of this study was to evaluate the effectiveness of three intervention programs to decrease fear of falling and improve physical functioning among older people with FoF and functional limitation. A randomized controlled trial was conducted (identifier NCT03211429). A hundred and twenty-five individuals were randomized to one of three interventions: Tai Chi (TC), cognitive behavioral therapy (CBT), or a control exercise group (PC). The primary outcomes were fear of falling and functionality. All postural interventions were performed weekly for 8 weeks. Compared to baseline, fear of falls significantly reduced in all groups (effect sizes d Cohen) TC 0.37, CBT 0.80, and PC 0.71). Similarly, compared to baseline, physical functioning improved in all groups (effect sizes: TC -0.49, CBT -0.49, and PC -0.83). In summary, the three intervention programs are effective on FoF and functionality, but, CBT is most effective on FoF and CP most effective for physical functioning.

Published
2018

50. Dynapenia and Sarcopenia as a Risk Factor for Disability in a Falls and Fractures Clinic in Older Persons.

Author

Benjumea, A-M, Curcio, C-L, Duque, G, Gómez, F, Benjumea, A-M, Curcio, C-L, Duque, G, and Gómez, F

Abstract

BACKGROUND: The role of sarcopenia and dynapenia in disability in older persons from falls and bone health clinics remain unknown. AIM: This study aims to compare the association of sarcopenia and dynapenia with physical and instrumental disability in a population of older persons attending a falls and fractures clinic. METHODS: This is a cross-sectional study in Manizales, Andes Mountains, Colombia. A cohort of 534 subjects (mean age = 74, 75% female) Sarcopenia was measured according to the European Working Group on Sarcopenia in Older People (EWGSOP) including an index of skeletal mass, muscle strength, and gait speed. Dynapenia was defined as a handgrip force ≤ 30 kg for men and ≤ 20 kg for women. RESULTS: Dynapenia and sarcopenia were present in 84.6% and 71.2% respectively. Both were more prevalent in older subjects and women than men. While sarcopenia was associated with body mass index and hypertension, dynapenia was associated with hypothyroidism and visual impairment. After controlling for all covariates, sarcopenia was associated with low IADL and mobility disability. CONCLUSIONS: Sarcopenia was associated with mobility, ADL and IADL disability. Dynapenia was not associated with disability in this high - risk population. Systematic assessment of sarcopenia should be implemented in falls and fractures clinics to identify sarcopenia and develop interventions to prevent functional decline among elderly individuals.

Published
2018

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