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1. The hidden side of infective endocarditis: Diagnostic and management of 500 consecutive cases in noncardiac surgery centers (2009–2018)

Author

Miró, Jose M., Ambrosioni, Juan, Hernández-Meneses, Marta, Téllez, Adrian, Pericàs, Juan M., Dahl, Anders, Moreno, Asuncion, Aguilar, Sergi, López, Alba, García de la Mària, Cristina, Cañas-Pacheco, María Alejandra, García-González, Javier, Almela, Manel, Zboromyrska, Yuliya, Casals, Climent, Morales, Francisco-Javier, Bosch, Jordi, Marco, Francesc, Vila, Jordi, Quintana, Eduard, Sandoval, Elena, Paré, Juan C., Falces, Carlos, Pereda, Daniel, Cartañá, Ramon, Ninot, Salvador, Azqueta, Manel, Sitges, Marta, Vidal, Barbara, Pomar, José L., Castella, Manuel, Tolosana, José M., Regueiro, Anders, Ortiz, José, Fita, Guillermina, Rovira, Irene, Perissinotti, Andrés, Fuster, David, Ramírez, Jose, Brunet, Mercè, Soy, Dolors, Castro, Pedro, Nicolás, David, Llopis, Jaume, Calzado, Sonia, Gasch, Oriol, Gomila-Grange, Aina, Pedrosa, Marc, Alguacil, Marina, Sanfeliu, Isabel, Guillaumet, Eva, Guillamon, Laura, Caresia, Ana Paula, Díaz, Emilio, Boix-Palop, Lucía, Dietl, Beatriz, Gisbert, Laura, Calbo, Esther, Xercavins, Mariona, Ibars, Sonia, Trenado, Josep, de los Ríos, Javier Díez, Reynaga, Esteban Alberto, Navarro, María, Montserrat, Silvia, Robles, Rocío, Cuquet, Jordi, Arrieta, Itziar, Costa, Núria, Martí, Carmina, Pulido, Ángeles, Ayats, Montserrat, Garro, Pau, Esquirol, Xavier, Bustamante, Marco A., Sanmartí, Montserrat, Cárdenas, Antonio, García, Gloria, Andrés, Marta, García, María Consuelo, Hanacsek, Carme Agustí, Dorca, Esther, Ortiz, María, Roca, Juan Manuel, Mollet, Fundació Sanitària, Tricas, José Maria, Maur, Elisabet, Romeo, Isabel, Vidal-Galve, Rosa, García, Xelo, Agustí, Carme, Tricas, José M., Díez de los Ríos, Javier, and Miró, José M.

Published
2023
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2. High delayed mortality after the first episode of Clostridium difficile infection

Author

Romero, José, Muriel, Alfonso, Giner, Livia, Federico, Ferrere, Rocío, Martínez-Ruiz S., Martos, Purificación, Sardiña, Cristina, Elena, Aguirre, Badía, Cristina, Perales, Alfonso, De Santos-Castro, Pedro A., Miguel, AngelBratos-Pérez, Cuellar, Sandra, Eva, Gonzalez, llinares, Pedro, Laura, Castelo, Morales, Isabel, Delgado-Iribarren, Alberto, Mairal, Pilar, Cózar, Alberto, Ramos-Martínez, Antonio, Merino, Esperanza, Martínez -García, Cristina, Shaw, Evelyn, Marrodán, Teresa, Calbo, Esther, Bereciartúa, Elena, Sánchez- Muñoz, Luis A., Salavert, Miguel, Pérez-Rodríguez, M. Teresa, García, Dácil, Bravo-Ferrer, J. María, Gálvez-Acebal, Juan, Henríquez, César, Cuquet, Jordi, Gil-Campesino, Helena, Torres, Luis, Sánchez-Porto, Antonio, Royuela, Ana, and Cobo, Javier

Published
2019
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3. The hidden side of infective endocarditis: Diagnostic and management of 500 consecutive cases in noncardiac surgery centers (2009–2018)

Author

Calzado, Sonia, primary, Hernández-Meneses, Marta, additional, Llopis, Jaume, additional, Boix-Palop, Lucía, additional, Dietl, Beatriz, additional, Calbo, Esther, additional, Andrés, Marta, additional, García, Xelo, additional, Agustí, Carme, additional, Dorca, Esther, additional, Tricas, José M., additional, Díez de los Ríos, Javier, additional, Cuquet, Jordi, additional, Cárdenas, Antonio, additional, Roca, Juan Manuel, additional, Ortiz, María, additional, Caresia, Ana Paula, additional, Guillamon, Laura, additional, Quintana, Eduard, additional, Ambrosioni, Juan, additional, Gasch, Oriol, additional, Miró, José M., additional, Miró, Jose M., additional, Téllez, Adrian, additional, Pericàs, Juan M., additional, Dahl, Anders, additional, Moreno, Asuncion, additional, Aguilar, Sergi, additional, López, Alba, additional, García de la Mària, Cristina, additional, Cañas-Pacheco, María Alejandra, additional, García-González, Javier, additional, Almela, Manel, additional, Zboromyrska, Yuliya, additional, Casals, Climent, additional, Morales, Francisco-Javier, additional, Bosch, Jordi, additional, Marco, Francesc, additional, Vila, Jordi, additional, Sandoval, Elena, additional, Paré, Juan C., additional, Falces, Carlos, additional, Pereda, Daniel, additional, Cartañá, Ramon, additional, Ninot, Salvador, additional, Azqueta, Manel, additional, Sitges, Marta, additional, Vidal, Barbara, additional, Pomar, José L., additional, Castella, Manuel, additional, Tolosana, José M., additional, Regueiro, Anders, additional, Ortiz, José, additional, Fita, Guillermina, additional, Rovira, Irene, additional, Perissinotti, Andrés, additional, Fuster, David, additional, Ramírez, Jose, additional, Brunet, Mercè, additional, Soy, Dolors, additional, Castro, Pedro, additional, Nicolás, David, additional, Calzado, Sonia, additional, Gomila-Grange, Aina, additional, Pedrosa, Marc, additional, Alguacil, Marina, additional, Sanfeliu, Isabel, additional, Guillaumet, Eva, additional, Díaz, Emilio, additional, Gisbert, Laura, additional, Xercavins, Mariona, additional, Ibars, Sonia, additional, Trenado, Josep, additional, de los Ríos, Javier Díez, additional, Reynaga, Esteban Alberto, additional, Navarro, María, additional, Montserrat, Silvia, additional, Robles, Rocío, additional, Arrieta, Itziar, additional, Costa, Núria, additional, Martí, Carmina, additional, Pulido, Ángeles, additional, Ayats, Montserrat, additional, Garro, Pau, additional, Esquirol, Xavier, additional, Bustamante, Marco A., additional, Sanmartí, Montserrat, additional, García, Gloria, additional, García, María Consuelo, additional, Hanacsek, Carme Agustí, additional, Mollet, Fundació Sanitària, additional, Tricas, José Maria, additional, Maur, Elisabet, additional, Romeo, Isabel, additional, and Vidal-Galve, Rosa, additional

Published
2023
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4. Current outcomes and predictors of treatment failure in patients with surgical site infection after elective colorectal surgery. A multicentre prospective cohort study

Author

Gomila, Aina, Badia, Josep M<ce:sup loc='post">a</ce:sup>, Carratalà, Jordi, Serra-Aracil, Xavier, Shaw, Evelyn, Diaz-Brito, Vicens, Castro, Antoni, Espejo, Elena, Nicolás, Carmen, Piriz, Marta, Brugués, Montserrat, Obradors, Josefina, Lérida, Ana, Cuquet, Jordi, Limón, Enric, Gudiol, Francesc, and Pujol, Miquel

Published
2017
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5. Late poor outcomes of Clostridioides difficile infections in oncological patients: A multicentre cohort study

Author

Calbo, Esther, primary, Hernández, Sergi, additional, Sopena, Nieves, additional, Castellá, Laia, additional, Lopez-Contreras, Joaquín, additional, Cuquet, Jordi, additional, López-Sánchez, Maria, additional, Pérez, Rafel, additional, Gudiol, Carlota, additional, Coloma, Ana, additional, Marimón, Mariló, additional, Espinach, Joan, additional, Andres, Marta, additional, Martos, Purificación, additional, Carvalho Rodrigues, Gonçalo, additional, and Limón, Enric, additional

Published
2023
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6. Clostridioides difficile infection recurrence in the VINCat hospitals: a prospective observational cohort study

Author

Pujol, Miquel, primary, Limón, Enric, additional, Sopena, Nieves, additional, Lopez-Contreras, Joaquín, additional, Castellá, Laia, additional, Cuquet, Jordi, additional, López-Sánchez, Maria, additional, Pérez, Rafel, additional, Gudiol, Carlota, additional, Coloma, Ana, additional, Marimón, Mariló, additional, Espinach, Joan, additional, Andres, Marta, additional, Martos, Purificación, additional, Hernández, Sergi, additional, Almendral, Alexander, additional, Saliba, Patrick, additional, Rodrigues, Gonçalo Carvalho, additional, Calbo, Esther, additional, and Group, VINCat Program, additional

Published
2022
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9. Efficacy and Safety of Fosfomycin Plus Imipenem as Rescue Therapy for Complicated Bacteremia and Endocarditis Due to Methicillin-Resistant Staphylococcus aureus: A Multicenter Clinical Trial

Author

FOSIMI Investigators, del Río, Ana, Gasch, Oriol, Moreno, Asunción, Peña, Carmen, Cuquet, Jordi, Soy, Dolors, Mestres, Carlos A., Suárez, Cristina, Pare, Juan C., Tubau, Fe, de la Mària, Cristina Garcia, Marco, Francesc, Carratalà, Jordi, Gatell, José M., Gudiol, Francisco, and Miró, José M.

Published
2014
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10. Trends in the epidemiology of catheter-related bloodstream infections; towards a paradigm shift, Spain, 2007 to 2019

Author

Badia-Cebada, Laia, Peñafiel, Judit, Saliba, Patrick, Andrés, Marta, Càmara, Jordi, Domènech, Dolors, Jiménez-Martínez, Emili, Marrón, Anna, Moreno, Encarna, Pomar, Virginia, Vaqué, Montserrat, Limón, Enric, Masats, Úrsula, Pujol, Miquel, Gasch Blasi, Oriol, Jover, Alfredo, Castellana, Dolors, Olona, Montserrat, García Pino, Antonia, Rebull Fatsini, Josep, Domènech, Mª France, Hornero, Ana, Ardanuy Tisaire, Carmen, Berbel Palau, Dàmaris, López-Contreras, Joaquín, Fernández, Engracia, Salgado, Xavier, Lérida, Ana, Martin, Lydia, Sopena, Nieves, Casas Garcia, Irma, Pérez, Rafael, Maraver, Encarna, Palau, Eva, Serrats, Pepi, Martínez, José Antonio, Santana, Gemina, Martínez, Ana, Ferrer, Lourdes, Moreno, Mª José, Calbo, Esther, Porta, Carolina, Smithson, Alex, de la Roca Toda, Maria, Aliu, Teresa, Camps, Susana, Ortega, Montserrat, Diaz-Brito, Vicens, Agusti, Carme, Perea Garcia, Miquel, Grau Palafox, Laura, Carrera, Raquel, Besolí, Anna, Horcajada, Juan Pablo, Gonzalez, Cristina, Cuquet, Jordi, Maldonado López, Demelsa Maria, Benítez, Rosa, Duch, Mireia, Blancas, David, Moreno, Esther, Villalba, Naiara, Martínez, Sara, García Flores, Àngels, Ferrer, Roser, Bisbe, Josep, Blascó, Montse, Castro Salom, Antoni, López, Ana Felisa, Espinach Alvarós, Joan, Perez, Àngels, Castander, David, Calaf, Elisabet, Clarós, Mercè, Bosch Ros, Núria, Montardit, Irene, Porta, Roser, De la Cruz Sol, Pilar, Coll Colell, Mª Rosa, García Penche Sanches, Rosa, Tricas, Josep Maria, Redon, Eva, Brugués, Montse, Linares, Laura, Cusco, Maria, Barrufet, Mª Pilar, Vidal, Elena, Barbadillo, Sandra, Marimón, Mariló, Meije, Yolanda, Laplace Enguinados, M.Rosa, Vila, Blanca, Coloma, Ana Guadalupe, López, Lucrecia, Campins Martí, Magda, Almirante Gragera, Benito, Ferrer, Carme, Juan Serra, Natalia, Farguell Carrera, Josep, Garcia Flores, Àngels, Milian Sanz, Marta, Moise, Alexandra, Jiménez Zarate, Ana Mª, Eito Navasal, M. Carmen, Garcia Ramirez, María Gracia, Armario Fernández, Mar, Universitat Autònoma de Barcelona, [Badia-Cebada L] Internal Medicine Department, Hospital Universitari Parc Taulí, Sabadell, Spain. School of Medicine, Universitat Autònoma de Barcelona, Sabadell, Spain. [Peñafiel J] Unit of Statistics, Hospital Universitari de Bellvitge/Institut d'Investigació Biomèdica de Bellvitge-IDIBELL, L'Hospitalet de Llobregat, Spain. [Saliba P] VINCat programme: Infection Control Catalan Programme, Barcelona, Spain. [Andrés M] Infectious Diseases Unit, Departament de Medicina Interna, Hospital de Terrassa, Consorci Sanitari de Terrassa, Spain. [Càmara J] Department of Microbiology, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain. Institut d'Investigació Biomèdica de Bellvitge-IDIBELL, L'Hospitalet de Llobregat, Spain. CIBER de Malalties Respiratòries (CIBERes), ISCIII, Madrid, Spain. [Domenech D] Infermera de control d'infeccions, Hospital Josep Trueta, Girona, Spain, and Consorci Sanitari de Terrassa

Subjects
Health Occupations::Medicine::Public Health::Epidemiology [DISCIPLINES AND OCCUPATIONS], Male, Catheterization, Central Venous, Catheters, Epidemiology, profesiones sanitarias::medicina::salud pública::epidemiología [DISCIPLINAS Y OCUPACIONES], Bacteremia, Infections, Cohort Studies, Virology, Sepsis, Humans, Prospective Studies, Espanya, Epidemiologia, Polyvinyl Chloride, Incidence, infecciones bacterianas y micosis::infección [ENFERMEDADES], Public Health, Environmental and Occupational Health, Fluids and Secretions::Body Fluids::Blood [ANATOMY], Catèters, Middle Aged, Infeccions, Bacterial Infections and Mycoses::Infection [DISEASES], Spain, Catheter-Related Infections, Infecció, líquidos y secreciones::líquidos corporales::sangre [ANATOMÍA], Female
Abstract

Background Catheter-related bloodstream infections (CRBSI) are frequent healthcare-associated infections and an important cause of death. Aim To analyse changes in CRBSI epidemiology observed by the Infection Control Catalan Programme (VINCat). Methods A cohort study including all hospital-acquired CRBSI episodes diagnosed at 55 hospitals (2007–2019) in Catalonia, Spain, was prospectively conducted. CRBSI incidence rates were adjusted per 1,000 patient days. To assess the CRBSI rate trend per year, negative binomial models were used, with the number of events as the dependent variable, and the year as the main independent variable. From each model, the annual rate of CRBSI diagnosed per 1,000 patient days and the incidence rate ratio (IRR) with its 95% confidence intervals (CI) were reported. Results During the study, 9,290 CRBSI episodes were diagnosed (mean annual incidence rate: 0.20 episodes/1,000 patient days). Patients’ median age was 64.1 years; 36.6% (3,403/9,290) were female. In total, 73.7% (n = 6,845) of CRBSI occurred in non-intensive care unit (ICU) wards, 62.7% (n = 5,822) were related to central venous catheter (CVC), 24.1% (n = 2,236) to peripheral venous catheters (PVC) and 13.3% (n = 1,232) to peripherally-inserted central venous catheters (PICVC). Incidence rate fell over the study period (IRR: 0.94; 95%CI: 0.93–0.96), especially in the ICU (IRR: 0.88; 95%CI: 0.87–0.89). As a whole, while episodes of CVC CRBSI fell significantly (IRR: 0.88; 95%CI: 0.87–0.91), peripherally-inserted catheter CRBSI (PVC and PICVC) rose, especially in medical wards (IRR PICVC: 1.08; 95%CI: 1.05–1.11; IRR PVC: 1.03; 95% 1.00-1.05). Conclusions Over the study, CRBSIs associated with CVC and diagnosed in ICUs decreased while episodes in conventional wards involving peripherally-inserted catheters increased. Hospitals should implement preventive measures in conventional wards.

Published
2022

11. Clinical and Epidemiological Characteristics of Streptococcus suis Infections in Catalonia, Spain

Author

Díez de los Ríos, Javier, primary, Reynaga, Esteban, additional, García-Gonzàlez, Merce, additional, Càmara, Jordi, additional, Ardanuy, Carmen, additional, Cuquet, Jordi, additional, Quesada, Maria D., additional, Navarro, Marian, additional, Vilamala, Anna, additional, Párraga-Niño, Noemi, additional, Quero, Sara, additional, Romero, Alba, additional, Benítez, Rosa M., additional, Altimiras, Jacint, additional, and Pedro-Botet, Maria Luisa, additional

Published
2021
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12. Late poor outcomes of Clostridioides difficileinfections in oncological patients: A multicentre cohort study

Author

Calbo, Esther, Hernández, Sergi, Sopena, Nieves, Castellá, Laia, Lopez-Contreras, Joaquín, Cuquet, Jordi, López-Sánchez, Maria, Pérez, Rafel, Gudiol, Carlota, Coloma, Ana, Marimón, Mariló, Espinach, Joan, Andres, Marta, Martos, Purificación, Carvalho Rodrigues, Gonçalo, and Limón, Enric

Abstract

Background Cancer has been associated with an increased risk of in-hospital mortality in CDI patients. However, data on delayed mortality in cancer patients with CDI are scarce.Aim/Objective The aim of the present study was to compare outcomes between oncological patients and the general population with Clostridioides difficileinfection (CDI) after 90 days of follow-up.Methods A multicenter prospective cohort study was conducted in 28 hospitals participating in the VINCat program. Cases were all consecutive adult patients who met the case definition of CDI. Sociodemographic, clinical, and epidemiological variables and evolution at discharge and after 90 days were recorded for each case.Findings/results The mortality rate was higher in oncological patients (OR = 1.70, 95% CI: 1.08–2.67). In addition, oncological patients receiving chemotherapy (CT) presented higher recurrence rates (18.5% vs 9.8%, p= 0.049). Among oncological patients treated with metronidazole, those with active CT showed a higher rate of recurrence (35.3% vs 8.0% p= 0.04).Discussion Oncological patients presented a higher risk of poor outcomes after CDI. Their early and late mortality rates were higher than in the general population, and in parallel, those undergoing chemotherapy (especially those receiving metronidazole) had higher rates of recurrence

Published
2023
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13. Value of second-trimester uterine artery pulsatility index in pregnancies with systemic lupus erythematosus and/or antiphospholipid syndrome.

Author

Canto, Maria J., Ortiz-Santamaria, Vera, Palau, Josep, Cuquet, Jordi, and Ojeda, Felipe

Abstract

Objective: To assess the value of the second trimester mean pulsatility index of the uterine arteries (MPI-UtA) to predict adverse perinatal outcome (APO) in women with systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS). Methods: Pregnancies with either an SLE diagnosis or with primary APS controlled at our Hospital during a 10 years period were included. MPI-UtA was performed between 19–23 weeks' gestation. The MPI-UtA was defined as abnormal when it was >95th centile. APO was defined as the presence of: preeclampsia (PE), small for gestational age (SGA) newborn, preterm delivery, placental abruption and fetal or neonatal death. Results: There were 39 ongoing pregnancies, 16 of them with SLE and 23 with primary APS. Nine patients had no previous pregnancy (23%). Globally, 35 live births were recorded, being the mean gestational age at delivery 38.1 ± 2.1 weeks and the mean birth weight 2835 ± 492 g. Abnormal MPI-UtA was found in 6 (15%) pregnancies, all of them (100%) had an APO: there were 4 fetal deaths and 2 further severe PE with live newborn. Normal MPI-UtA was shown in the remaining 33 (84.6%); of them, 6 (18%) had an APO: one late PE with a premature newborn, another one severe preterm baby and 4 SGA term newborns. No cases of perinatal death occurred in this group. Therefore, accuracy of MPI-UtA evaluation for APO was: sensitivity 50%, specificity 100%, PPV 100% and NPV 82%, respectively (p <.001). Conclusion: Abnormal second-trimester uterine artery Doppler evaluation is highly predictive for adverse perinatal outcome in pregnancies affected by SLE or APS. [ABSTRACT FROM AUTHOR]

Published
2022
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16. Características clínicas, evolutivas y pronóstico de la endocarditis infecciosa en diez centros de cataluña central: Estudio retrospectivo de 910 casos (2009-2018)

Author

Hernández-Meneses, Marta, primary, Isbert, Sonia Calzado, additional, Llopis, Jaume, additional, Palop, Lucía Boix, additional, Ríos, Javier Díez-De Los, additional, Cuquet, Jordi, additional, Cárdenas, Antoni, additional, Ambrosioni, Juan, additional, Gasch, Oriol, additional, and Miró, José María, additional

Published
2020
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17. Clostridioides difficileinfection recurrence in the VINCat hospitals: a prospective observational cohort study

Author

Pujol, Miquel, Limón, Enric, Sopena, Nieves, Lopez-Contreras, Joaquín, Castellá, Laia, Cuquet, Jordi, López-Sánchez, Maria, Pérez, Rafel, Gudiol, Carlota, Coloma, Ana, Marimón, Mariló, Espinach, Joan, Andres, Marta, Martos, Purificación, Hernández, Sergi, Almendral, Alexander, Saliba, Patrick, Rodrigues, Gonçalo Carvalho, Calbo, Esther, and Group, VINCat Program

Abstract

Background:The 2016 cumulative incidence of Clostridioides difficileinfection (CDI) in Spain was reported by the European Center for Disease Control to be above the mean of other European countries. The aim of this multicenter prospective observational cohort study was to examine the risk factors that determine 90-day CDI recurrence in Catalonia, Spain. Methods:The study included 558 consecutive adults admitted to hospital who had a symptomatic, first positive CDI diagnosis. Sociodemographic, clinical and epidemiological variables were recorded. The primary outcome was 90-day CDI recurrence. Results:In this Catalan population, having received more than one course of antibiotics in the 30 days prior to CDI diagnosis (odds ratio: 2.459; 95% CI: 1.195–5.060; p = 0.015) and active chemotherapy (odds ratio: 4.859; 95% CI: 1.495–15.792; p = 0.009) are significant predictors of 90-day CDI recurrence. Conclusion:The identification of independent risk factors of 90-day CDI recurrence will enable the optimization of preventive measures in at-risk populations.

Published
2022
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18. High delayed mortality after the first episode of Clostridium difficile infection

Author

Cózar, Alberto, primary, Ramos-Martínez, Antonio, additional, Merino, Esperanza, additional, Martínez -García, Cristina, additional, Shaw, Evelyn, additional, Marrodán, Teresa, additional, Calbo, Esther, additional, Bereciartúa, Elena, additional, Sánchez- Muñoz, Luis A., additional, Salavert, Miguel, additional, Pérez-Rodríguez, M. Teresa, additional, García, Dácil, additional, Bravo-Ferrer, J. María, additional, Gálvez-Acebal, Juan, additional, Henríquez, César, additional, Cuquet, Jordi, additional, Gil-Campesino, Helena, additional, Torres, Luis, additional, Sánchez-Porto, Antonio, additional, Royuela, Ana, additional, Cobo, Javier, additional, Romero, José, additional, Muriel, Alfonso, additional, Giner, Livia, additional, Federico, Ferrere, additional, Rocío, Martínez-Ruiz S., additional, Martos, Purificación, additional, Sardiña, Cristina, additional, Elena, Aguirre, additional, Badía, Cristina, additional, Perales, Alfonso, additional, De Santos-Castro, Pedro A., additional, Miguel, AngelBratos-Pérez, additional, Cuellar, Sandra, additional, Eva, Gonzalez, additional, llinares, Pedro, additional, Laura, Castelo, additional, Morales, Isabel, additional, Delgado-Iribarren, Alberto, additional, and Mairal, Pilar, additional

Published
2019
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20. Prediction of recurrent clostridium difficile infection at the bedside: the GEIH-CDI score

Author

Cobo, Javier, primary, Merino, Esperanza, additional, Martínez, Cristina, additional, Cózar-Llistó, Alberto, additional, Shaw, Evelyn, additional, Marrodán, Teresa, additional, Calbo, Esther, additional, Bereciartúa, Elena, additional, Sánchez-Muñoz, Luis A., additional, Salavert, Miguel, additional, Pérez-Rodríguez, M. Teresa, additional, García-Rosado, Dácil, additional, Bravo-Ferrer, J. María, additional, Gálvez-Acebal, Juan, additional, Henríquez-Camacho, César, additional, Cuquet, Jordi, additional, Pino-Calm, Berta, additional, Torres, Luis, additional, Sánchez-Porto, Antonio, additional, Fernández-Félix, Borja M., additional, Romero, José, additional, Muriel, Alfonso, additional, Giner, Livia, additional, Boix, Vicente, additional, Ramos-Martínez, Antonio, additional, Martínez, Rocío, additional, Martos, Purificación, additional, Arch, Olga, additional, Sardiña, Cristina, additional, Aguirre, Elena, additional, Badía, Cristina, additional, Boix, Lucía, additional, Perales, Ildefonso, additional, De Santos-Castro, Pedro A., additional, Bratos-Pérez, Miguel Angel, additional, Cuellar, Sandra, additional, González, Eva, additional, Soto, Adriana, additional, Sousa, Adrián, additional, Llinares, Pedro, additional, Castelo, Laura, additional, Morales, Isabel, additional, Sojo, Jesús, additional, Delgado-Iribarren, Alberto, additional, Martí, Carmina, additional, Vázquez, Rosa, additional, and Mairal, Pilar, additional

Published
2018
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23. Diagnosis of tuberculosis infection by tuberculin skin test and a whole-blood interferon-γ release assay in patients considered for anti–tumor necrosis factor-α therapy

Author

Casas, Susana, primary, Andreu, Ana, additional, Juanola, Xavier, additional, Bordas, Xavier, additional, Alcaide, Fernando, additional, Moure, Raquel, additional, Anibarro, Luis, additional, Cuchí, Eva, additional, Esteve, Maria, additional, Ortiz, Vera, additional, Guerra, Maria Rosario, additional, Rodríguez, Jesus, additional, Reina, Delia, additional, Salvador, Georgina, additional, Guardiola, Jordi, additional, Surís, Xavier, additional, Pascual, Maria Angeles, additional, Martí, Carmina, additional, Martínez-Lacasa, Xavier, additional, Cuquet, Jordi, additional, Gonzalez, Lucia, additional, and Santin, Miguel, additional

Published
2011
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25. Efficacy and Safety of Fosfomycin Plus Imipenem as Rescue Therapy for Complicated Bacteremia and Endocarditis Due to Methicillin-Resistant Staphylococcus aureus: A Multicenter Clinical Trial.

Author

del Río, Ana, Gasch, Oriol, Moreno, Asunción, Peña, Carmen, Cuquet, Jordi, Soy, Dolors, Mestres, Carlos A., Suárez, Cristina, Pare, Juan C., Tubau, Fe, Garcia de la Mària, Cristina, Marco, Francesc, Carratalà, Jordi, Gatell, José M., Gudiol, Francisco, and Miró, José M.

Subjects
MEDICATION safety, DRUG efficacy, BACTEREMIA treatment, METHICILLIN-resistant staphylococcus aureus, FOSFOMYCIN, IMIPENEM, ENDOCARDITIS, CLINICAL trials
Abstract

We performed a clinical trial to evaluate the efficacy and safety of fosfomycin plus imipenem as rescue therapy for complicated methicillin-resistant Staphylococcus aureus bacteremia and infective endocarditis. Blood cultures were negative 72 hours after the first dose in all patients.Background. There is an urgent need for alternative rescue therapies in invasive infections caused by methicillin-resistant Staphylococcus aureus (MRSA). We assessed the clinical efficacy and safety of the combination of fosfomycin and imipenem as rescue therapy for MRSA infective endocarditis and complicated bacteremia.Methods. The trial was conducted between 2001 and 2010 in 3 Spanish hospitals. Adult patients with complicated MRSA bacteremia or endocarditis requiring rescue therapy were eligible for the study. Treatment with fosfomycin (2 g/6 hours IV) plus imipenem (1 g/6 hours IV) was started and monitored. The primary efficacy endpoints were percentage of sterile blood cultures at 72 hours and clinical success rate assessed at the test-of-cure visit (45 days after the end of therapy).Results. The combination was administered in 12 patients with endocarditis, 2 with vascular graft infection, and 2 with complicated bacteremia. Therapy had previously failed with vancomycin in 9 patients, daptomycin in 2, and sequential antibiotics in 5. Blood cultures were negative 72 hours after the first dose of the combination in all cases. The success rate was 69%, and only 1 of 5 deaths was related to the MRSA infection. Although the combination was safe in most patients (94%), a patient with liver cirrhosis died of multiorgan failure secondary to sodium overload. There were no episodes of breakthrough bacteremia or relapse.Conclusions. Fosfomycin plus imipenem was an effective and safe combination when used as rescue therapy for complicated MRSA bloodstream infections and deserves further clinical evaluation as initial therapy in these infections. [ABSTRACT FROM AUTHOR]

Published
2014

26. Surgeon-led 7-VINCut Antibiotic Stewardship Intervention Decreases Duration of Treatment and Carbapenem Use in a General Surgery Service.

Author

Badia, Josep M., Batlle, Maria, Juvany, Montserrat, Ruiz-de León, Patricia, Sagalés, Maria, Pulido, M Angeles, Molist, Gemma, and Cuquet, Jordi

Subjects
ANTIMICROBIAL stewardship, TREATMENT duration, SURGICAL site infections, CARBAPENEMS
Abstract

Antibiotic stewardship programs optimize the use of antimicrobials to prevent the development of resistance and improve patient outcomes. In this prospective interventional study, a multidisciplinary team led by surgeons implemented a program aimed at shortening the duration of antibiotic treatment <7 days. The impact of the intervention on antibiotic consumption adjusted to bed-days and discharges, and the isolation of multiresistant bacteria (MRB) was also studied. Furthermore, the surgeons were surveyed regarding their beliefs and feelings about the program. Out of 1409 patients, 40.7% received antibiotic therapy. Treatment continued for over 7 days in 21.5% of cases, and, as can be expected, source control was achieved in only 48.8% of these cases. The recommendations were followed in 90.2% of cases, the most frequent being to withdraw the treatment (55.6%). During the first 16 months of the intervention, a sharp decrease in the percentage of extended treatments, with R2 = 0.111 was observed. The program was very well accepted by surgeons, and achieved a decrease in both the consumption of carbapenems and in the number of MRB isolations. Multidisciplinary stewardship teams led by surgeons seem to be well received and able to better manage antibiotic prescription in surgery. [ABSTRACT FROM AUTHOR]

Published
2021
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