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38 results on '"Cuomo, Pierluigi"'

1. Extra-abdominal desmoid tumor fibromatosis: a multicenter EMSOS study

Author

Cuomo, Pierluigi, Scoccianti, Guido, Schiavo, Alberto, Tortolini, Valentina, Wigley, Catrin, Muratori, Francesco, Matera, Davide, Kukushkina, Mariia, Funovics, Philipp Theodor, Lingitz, Marie-Theres, Windhager, Reinhard, Dijkstra, Sander, Jasper, Jorrit, Müller, Daniel A., Kaiser, Dominik, Perlaky, Tamás, Leithner, Andreas, Smolle, Maria Anna, and Campanacci, Domenico Andrea

Published
2021
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2. Biomechanics of double bundle anterior cruciate ligament reconstruction

Author

Cuomo, Pierluigi, Amis, Andrew, and Bull, Anthony

Subjects
617.582059
Abstract

The scope of this thesis was to verify whether anatomic reconstruction of the anterior cruciate ligament (ACL) with close replication of its two main bundles ensures better knee kinematics and improved clinical outcomes. The thesis articulates into three parts. In the first part the current anatomic knowledge is reviewed with regard to the double bundle ACL structure and an anatomic study is presented: its results will serve as a basis for the following kinematics and clinical studies. In the second part, a method to investigate cadaveric knee laxities is presented and employed to test intact and ACL deficient knees and to explore the function of the anteromedial and posterolateral ACL bundles. The ACL was found to be a primary restrain to anterior tibial translation mainly because of the action of the anteromedial bundle, with the posterolateral acting as a secondary restrain. Both bundles then were found to equally contribute to control the limit of internal rotation. Finally the reconstruction of both ACL bundles was demonstrated to be superior to traditional single bundle reconstruction in restoring intact knee anterior and rotational laxity. The third part focused on double bundle surgical technique with the development of surgical instruments that were validated on cadaver knees and found to be extremely accurate on the tibial side, less on the femur. Surgical technique was then improved and introduced into clinical practice. Two clinical studies were conducted and demonstrated the superiority of double bundle anatomic reconstruction in improving subjective and objective results as well as instrumented knee laxity measurements. In conclusion the main finding of this thesis was that, after a deep understanding of ACL anatomy and biomechanics, the replication at surgery of its native structure improves knee stability and patients’ satisfaction.

Published
2012
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9. The Effects of Different Tensioning Strategies on Knee Laxity and Graft Tension After Double-Bundle Anterior Cruciate Ligament Reconstruction

Author

Cuomo, Pierluigi, Reddi Boddu Siva Rama, Krishna, Bull, Anthony M. J., and Amis, Andrew A.

Subjects
Transplantation of organs, tissues, etc. -- Physiological aspects -- Research, Knee -- Physiological aspects -- Research, Health, Sports and fitness, Physiological aspects, Research
Abstract

Byline: Pierluigi Cuomo, MD (First Orthopaedic Clinic, University of Florence, Florence, Italy, Department of Mechanical Engineering, Imperial College London, London, United Kingdom, Department of Bioengineering, Imperial College London, London, United [...]

Published
2007
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15. Contributors

Author

Abraham, John A., primary, Aglietti, Paolo, additional, Albright, Jay C., additional, Anderson, Allen F., additional, Apel, Peter J., additional, Azer, Nigel M., additional, Balsamo, Luke H., additional, Bendor, David B., additional, Berde, Charles B., additional, Brown, Treg D., additional, Cahill, Bernard, additional, Cannon, W. Dilworth, additional, Cassella, Michelina, additional, Chambers, Henry G., additional, Ciardullo, Antonio, additional, Cook, Jennifer L., additional, Cuomo, Pierluigi, additional, Davis, J.T., additional, Dulberg, Harvey N., additional, d'Hemecourt, Pierre A., additional, Faigenbaum, Avery D., additional, Flynn, John M., additional, Fowler, Peter J., additional, Franco, John, additional, Ganley, Theodore J., additional, Gebhardt, Mark C., additional, Gerbino, Peter G., additional, Gustafson, Carl, additional, Guzzanti, Vincenzo, additional, Hangody, László, additional, Harner, Christopher D., additional, Hinton, Richard Y., additional, Ho, Charles P., additional, Iobst, Christopher, additional, Ireland, Mary Lloyd, additional, Jacobi, Matthias, additional, Jakob, Roland P., additional, Jaramillo, Diego, additional, Kasser, James R., additional, Katz, Danielle A., additional, Klingele, Kevin E., additional, Kocher, Mininder S., additional, Larson, Roger V., additional, Latz, Kevin H., additional, Losee, Ronald E., additional, Luke, Anthony C., additional, Maffulli, Nicola, additional, Mah, Jung Y., additional, Mandlebaum, Bert R., additional, Micheli, Lyle J., additional, Minas, Tom, additional, Moroz, Paul J., additional, Murray, Martha Meaney, additional, Murray, Michael F., additional, Navedo-Rivera, Andrés T., additional, Nelson, Scott C., additional, Nielson, Jason H., additional, O'Brien, Michael J., additional, Otsuka, Norman Y., additional, Ott, Susan M., additional, Paletta, George A., additional, Pfeiffer, Ron, additional, Ráthonyi, Gábor, additional, Richard, Kathleen, additional, Rodkey, William G., additional, Sadhasivam, Senthilkumar, additional, Shapiro, Frederic, additional, Sharma, Krishn M., additional, Shea, Kevin G., additional, Smith, Angela D., additional, Stanitski, Carl L., additional, Stanitski, Deborah, additional, Steadman, J. Richard, additional, Stracciolini, Andrea, additional, Sun, Edward C., additional, Sundel, Robert P., additional, Tokish, John M., additional, Wasserlauf, Brett L., additional, Wong, Jason K.F., additional, Woodward, Amy L., additional, and Yin, Yi-Meng, additional

Published
2006
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17. Allograft Reconstruction of the Extensor Mechanism after Resection of Soft Tissue Sarcoma

Author

Müller, Daniel A; https://orcid.org/0000-0002-5768-228X, Beltrami, Giovanni, Scoccianti, Guido, Cuomo, Pierluigi, Totti, Francesca, Capanna, Rodolfo, Müller, Daniel A; https://orcid.org/0000-0002-5768-228X, Beltrami, Giovanni, Scoccianti, Guido, Cuomo, Pierluigi, Totti, Francesca, and Capanna, Rodolfo

Abstract

Introduction Soft tissue tumors around the knee joint still pose problems for the excision and subsequent reconstruction. Methods In the 6 included patients the soft tissue sarcoma has its base on the anterior surface of the extensor mechanism and expands towards the skin. The entire extensor apparatus (quadriceps tendon, patella, and patellar tendon) was resected and replaced by a fresh-frozen allograft. Results The mean follow-up was 6.7 years (range: 2-12.4 years). In two patients a local recurrence occurred, resulting in a 5-year local recurrence-free rate of 66.7% (95% CI: 19.5%-90.4%). Distant metastases were found in 4 patients resulting in a 5-year metastasis-free rate of 33.3% (95% CI: 4.6%-67.5%). Two patients underwent at least one revision surgery, including one patient in whom the allograft had to be removed. According to the ISOLS function score 24.7 points (range: 19-28 points) were achieved at the last follow-up. The mean active flexion of the knee joint was 82.5° (range: 25-120°) and a mean extension lag of 10° (range: 0-30°) was observed. Conclusions The replacement of the extensor mechanism by an allograft is a reasonable option, allowing wide margins and restoration of active extension in most patients. Trial Registration The presented study is listed on the ISRCTN registry with trial number ISRCTN63060594.

Published
2018

18. Liposarcoma: Clinico-pathological analysis, prognostic factors and survival in a series of 307 patients treated at a single institution

Author

Muratori, Francesco, primary, Frenos, Filippo, additional, Bettini, Leonardo, additional, Matera, Davide, additional, Mondanelli, Nicola, additional, Scorianz, Maurizio, additional, Cuomo, Pierluigi, additional, Scoccianti, Guido, additional, Beltrami, Giovanni, additional, Greto, Daniela, additional, Livi, Lorenzo, additional, Baldi, Giacomo, additional, Roselli, Giuliana, additional, Capanna, Rodolfo, additional, and Campanacci, Domenico Andrea, additional

Published
2018
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25. Biomechanics of Double Bundle Anterior Cruciate Ligament Reconstruction

Author

Cuomo, Pierluigi, Amis, Andrew, and Bull, Anthony

Subjects
musculoskeletal system, human activities
Abstract

The scope of this thesis was to verify whether anatomic reconstruction of the anterior cruciate ligament (ACL) with close replication of its two main bundles ensures better knee kinematics and improved clinical outcomes. The thesis articulates into three parts. In the first part the current anatomic knowledge is reviewed with regard to the double bundle ACL structure and an anatomic study is presented: its results will serve as a basis for the following kinematics and clinical studies. In the second part, a method to investigate cadaveric knee laxities is presented and employed to test intact and ACL deficient knees and to explore the function of the anteromedial and posterolateral ACL bundles. The ACL was found to be a primary restrain to anterior tibial translation mainly because of the action of the anteromedial bundle, with the posterolateral acting as a secondary restrain. Both bundles then were found to equally contribute to control the limit of internal rotation. Finally the reconstruction of both ACL bundles was demonstrated to be superior to traditional single bundle reconstruction in restoring intact knee anterior and rotational laxity. The third part focused on double bundle surgical technique with the development of surgical instruments that were validated on cadaver knees and found to be extremely accurate on the tibial side, less on the femur. Surgical technique was then improved and introduced into clinical practice. Two clinical studies were conducted and demonstrated the superiority of double bundle anatomic reconstruction in improving subjective and objective results as well as instrumented knee laxity measurements. In conclusion the main finding of this thesis was that, after a deep understanding of ACL anatomy and biomechanics, the replication at surgery of its native structure improves knee stability and patients’ satisfaction.

Published
2010

33. Atypical lipomatous tumor: retrospective analysis, prognostic factors and MRI in differential diagnosis.

Author

Muratori, Francesco, Roselli, Giuliana, Bettini, Leonardo, Frenos, Filippo, D'Arienzo, Antonio, Campanacci, Domenico Andrea, Mondanelli, Nicola, Matera, Davide, Cuomo, Pierluigi, Scoccianti, Guido, Beltrami, Giovanni, Totti, Francesca, and Capanna, Rodolfo

Subjects
*TUMOR diagnosis, *MAGNETIC resonance imaging, *DIFFERENTIAL diagnosis, *TUMOR treatment, TUMOR surgery
Abstract

Background. Authors analyzed retrospectively 98 Atypical Lipomatous Tumor (ALT) treated at a single institution, 96% of which was localized to the extremities and 4% to the trunk, assessing MRI, surgical treatment, local recurrence, follow-up and de-differentiation ability. Methods. Authors used MRI in order to identify ALT size, site, the presence of septa and contrast enhancement. Surgical margins were divided at final histology in wide/radical, marginal and intralesional. Results. The most common localization was the lower limb (84% of cases), 52% of cases showed size larger than 10 cm; 80% of cases were deep-seated. MRI revealed thick septa in 83% and contrast enhancement in 78% of the cases. Eleven local recurrences of the disease (11%) were observed, with only surgical margins representing a significant prognostic factor on local recurrence (p = 0.0007). No de-differentiation was reported nor metastatic spread. Conclusions. The slow growth and the dedifferentiation ability in ALT needs a long follow-up. MRI with contrast is the imaging method of choice. The optimal treatment is wide/radical resection. [ABSTRACT FROM AUTHOR]

Published
2018

34. Extra-abdominal desmoid tumor fibromatosis: a multicenter EMSOS study

Author

Guido Scoccianti, Reinhard Windhager, Alberto Schiavo, P. D. Sander Dijkstra, Maria Anna Smolle, Catrin Wigley, Francesco Muratori, Mariia Kukushkina, Pierluigi Cuomo, Valentina Tortolini, Domenico Andrea Campanacci, Philipp T. Funovics, Tamás Perlaky, Daniel Müller, Davide Matera, Jorrit Jasper, Marie-Theres Lingitz, Dominik Kaiser, Andreas Leithner, University of Zurich, and Cuomo, Pierluigi

Subjects
Male, Cancer Research, Biopsy, 0302 clinical medicine, Recurrence, Surgical oncology, Medicine, 1306 Cancer Research, 030212 general & internal medicine, Child, RC254-282, Aged, 80 and over, Fibromatosis, Disease Management, Soft tissue, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Middle Aged, Prognosis, Combined Modality Therapy, Fibromatosis, Aggressive, Treatment Outcome, medicine.anatomical_structure, Oncology, Child, Preschool, 030220 oncology & carcinogenesis, Cohort, Disease Progression, Female, 10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center, 2730 Oncology, Radiology, Adult, medicine.medical_specialty, Adolescent, Extra abdominal, Fibromatosis, Abdominal, 610 Medicine & health, Young Adult, 03 medical and health sciences, 1311 Genetics, Genetics, Recurrent disease, Humans, Aged, Retrospective Studies, business.industry, Research, medicine.disease, Shoulder girdle, Observational study, business
Abstract

Background Extra-abdominal desmoid tumor fibromatosis (DTF) is a rare, locally aggressive soft tissue tumour. The best treatment modality for this patient cohort is still object of debate. Questions/purpose This paper aimed to (1) to compare the outcomes of DTF after different treatment modalities, (2) to assess prognostic factors for recurrence following surgical excision, and (3) to assess prognostic factors for progression during observation. Methods This was a retrospective multicenter study under the patronage of the European Musculoskeletal Oncology Society (EMSOS). All seven centres involved were tertiary referral centres for soft tissue tumours. Baseline demographic data was collected for all patients as well as data on the diagnosis, tumour characteristics, clinical features, treatment modalities and whether they had any predisposing factors for DTF. Results Three hundred eighty-eight patients (240 female, 140 male) with a mean age of 37.6 (±18.8 SD, range: 3–85) were included in the study. Two hundred fifty-seven patients (66%) underwent surgical excision of ADF, 70 patients (18%) were observed without therapy, the residual patients had different conservative treatments. There were no significant differences in terms of tumour recurrence or progression between the different treatment groups. After surgical excision, younger age, recurrent disease and larger tumour size were risk factors for recurrence, while tumours around the shoulder girdle and painful lesions were at risk of progression in the observational group. Conclusion Local recurrence rate after surgery was similar to progression rates under observation. Hence, observation in DTF seems to be justified, considering surgery in case of dimensional progression in 2 consecutive controls (3 and 6 months) and in painful lesions, with particular attention to lesions around the shoulder girdle.

Published
2021

37. Pre-operative diclofenac HPβCD for pain control of needle biopsy in musculoskeletal neoplasm: preliminary results.

Author

D'Arienzo, Antonio, Beltrami, Giovanni, Mancini, Daniele, Scoccianti, Guido, Cuomo, Pierluigi, Muratori, Francesco, Matera, Davide, Ippolito, Massimiliano, Mondanelli, Nicola, Frenos, Filippo, Totti, Francesca, and Capanna, Rodolfo

Subjects
*NEEDLE biopsy, *PAIN management, *MUSCULOSKELETAL system, *DICLOFENAC, *TRAMADOL, *DRUG dosage, *TUMORS
Abstract

Needle biopsy is the main standard method used for diagnosis of musculoskeletal tumors of the limbs and superficial trunk. Pain control during this procedure is through the use of Local Anaestetic (L.A.). In order to achieve a complete pain control in our cases, recently we started using diclofenac HPβCD 50 mg via s.c. preoperativly. We present the clinical results of a non-randomized study of two eterogeneous groups of patients: "Experimental" Group (1): diclofenac HPβCD 50 mg via s.c. one hour before surgical procedure, local anesthesia and ev. diclofenac HPβCD 50 mg via s.c. 12 hours postoperative; "Conventional" Group (2): local anesthesia and ev. postoperative tramadol 100 mg via oral for pain control. In October 2014, at the Department of Orthopedic Oncology and Reconstructive Surgery of Florence, 37 musculoskeletal biopsies for a bone or a soft tissue lesion were performed. Exclusion criteria for this study were: known allergies to lidocaine, diclofenac, tramadol; known gastric or duodenal ulcers; known gastrointestinal bleed or perforation; refusal of the patients to collaborate. For one or more of these reasons, 6 patients were excluded from this study. In the Group 1, 10 patients (59%) referred no pain during the surgical procedure (8/14 biopsies on soft tissue and 2/3 on bone). In 5 cases (29%) no exacerbation of previous chronic pain, and in 2 cases (12%) a progression of local pain after biopsy (average 1 points higher in the VAS). In Group 2, only 6 patients (42%) did not have any pain during the procedure, 4 (29%) no exacerbation of previous chronic pain and 4 (29%) a progression of local pain (average 2 points higher in the VAS). Despite similar results in both Groups, Group 1 seemed to have a mild better control of perioperative pain. The use of diclofenac HPβCD 50 mg preoperative seems to be a rational approach for minimizing perioperative pain and the preliminary data of our study seem encouraging. Obviously many bias are present in this study (small numbers of cases, heterogeneity of diseases, association with local anesthetic, non-randomized study, comparison between preoperative versus postoperative treatment) and this cannot absolutely be considerate as definitive conclusions. [ABSTRACT FROM AUTHOR]

Published
2015

38. Contributors

Author

Aglietti, Paolo, Alford, J. Winslow, Amendola, Annunziato, Argenson, Jean-Noël A., Arnoczky, Steven P., Bach, Bernard R., Jr., Backstein, David, Banks, Scott A., Bansal, Sanjiv, Barbour, Scott A., Battaglia, Michael, Battaglia, Todd C., Baumfeld, Joshua, Beauchamp, Christopher P., Bergfeld, John A., Bernasek, Thomas, Blaha, J. David, Bourne, Robert B., Brassard, Marc F., Briggs, K.K., Brown, Thomas E., Brull, Richard, Buckwalter, Joseph A., Bugbee, William D., Busch, Michael T., Caborn, David N.M., Callaghan, John J., Chhabra, Anikar, Chong, Chang Haw, Clark, Charles R., Clarke, Henry D., Cole, Brian J., Collier, John P., Crawford, Matthew J., Creighton, R. Alexander, Cuomo, Pierluigi, Cushner, Fred D., Dahm, Diane L., Damron, Timothy A., Dellon, A. Lee, Dennis, Douglas A., Dickey, Ian D., Dietrick, Todd B., DiGioia, Anthony M., III, DiPasquale, Thomas, Dodds, Julie A., Driban, Jeffrey B., Duska, Zsófia, Easley, Mark E., Eickmann, Thomas H., Fanelli, Gregory C., Faris, Philip M., Farrell, Christopher M., Fehring, Thomas K., Flynn, John M., Foster, Lynanne J., Franks, Andrew G., Jr., Friedman, Marc J., Friedman, Richard J., Fitz, Wolfgang, Fu, Freddie H., Fulkerson, John P., Gallagher, John A., Ganley, Theodore J., Giron, Francesco, Goradia, Vipool K., Gotlin, Robert S., Greenwald, A. Seth, Gross, Allan, Hafez, Mahmoud A., Haidukewych, George J., Hangody, Lázsló, Hanssen, Arlen D., Harman, Melinda K., Harner, Christopher D., Haynes, David E., Healy, William L., Herrera, Joseph E., Hinton, Richard Y., Hofmann, Aaron A., Holt, Ginger E., Huard, Johnny, Hungerford, David S., Hungerford, Marc W., Infante, Anthony, Insall, John N., Iorio, Richard, Jacofsky, David J., Jaramaz, Branislav, Jarvis, James G., Johnston, Charles E., II, Kaposi, Novák Pál, Karistinos, Anastassios, Kessler, Craig M., Khanuja, Harpal S., King, Warren, Klimkiewicz, John J., Klingele, Kevin, Knapke, Donald M., Kocher, Mininder S., Komistek, Richard D., Krackow, Kenneth A., Kuhn, John E., Lahav, Amit, Lang, Jason E., Leone, James M., Lephart, Scott M., Lewis, Randall J., Lindvall, Eric M., Lionberger, David R., Liporace, Frank, Liu, Steve S., Liu, T. Thomas, Lonner, Jess H., Lotke, Paul A., Lyons, Steven, Mahfouz, Mohamed R., Manifold, Stephen G., Mason, J. Bohannon, Masur, Henry, Math, Kevin R., Matthews, Leslie S., McAuley, James P., McGuire, David A., Melton, Nathan M., Meneghini, R. Michael, Miller, Theodore T., Minas, Tom, Mologne, Timothy S., Mont, Michael A., Mor, Adam, Morra, Edward A., Mulhall, Kevin J., Munjal, Sandeep, Nakasone, Cass, Neel, Michael D., O'Connor, Mary I., Pagnano, Mark W., Parker, Richard D., Parker, Todd A., Paulos, Lonnie E., Pedersen, Henrik B., Petchprapa, Catherine, Peterson, Lars, Petrie, Russell S., Poilvache, Pascal, Post, W.R., Presutti, Anthony H., Pruitt, Lisa A., Radnay, Craig S., Ragland, Phillip S., Randall, Robert Lor, Reiffel, Robert Siskind, Ries, Michael D., Rodkey, William G., Rodrigo, Juan J., Rorabeck, Cecil H., Rosenberg, Aaron G., Safir, Oleg, Saleh, Khaled J., Sanders, Roy, Scott, Richard D., Scott, Susan Craig, Scott, W. Norman, Scuderi, Giles R., Sekiya, Jon K., Selleck, Alison, Sharma, Krishn M., Sharrock, Nigel E., Silver, Stephen G., Stanitski, Carl L., Steadman, J. Richard, Stiehl, James B., Stuart, Michael J., Stulberg, S. David, Swanik, Charles Buz, Szerb, Imre, Templeton, Kimberly, Tria, Alfred J., Jr., Uhthoff, Hans K., Unger, Anthony S., Vail, Thomas Parker, Van Citters, Douglas W., Verma, Nikhil, Vigorita, Vincent J., Vince, Kelly G., Walker, James A., Weiss, Kurt R., Whiddon, David R., Whiteside, Leo A., Wickiewicz, Thomas L., Wind, William M., Wojtys, Edward M., and Zaidi, Syed Furqan

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