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534 results on '"Cunha-Neto, Edecio"'

1. MiRNA-30d and miR-770-5p as potential clinical risk predictors of Vasoplegic Syndrome in Patients undergoing on-pump coronary artery bypass grafting

Author

Vilca Mejia, Omar Asdrúbal, de Souza, Renato Cesar, S. Santos, Aritania, Meneghini, Bianca, Carvalho Silva, Ana Carolina, Visconde Brasil, Guilherme, Oliveira Carvalho Rigaud, Vagner, Palma Dallan, Luís Roberto, Pinho Moreira, Luiz Felipe, Ferreira Lisboa, Luiz Augusto, Oliveira Dallan, Luís Alberto, Kalil, Jorge, Cunha-Neto, Edecio, Rodrigues Pinto Ferreira, Ludmila, and Biscegli Jatene, Fábio

Published
2023
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4. Correction: The oldest unvaccinated Covid-19 survivors in South America

Author

de Castro, Mateus V., Silva, Monize V. R., Naslavsky, Michel S., Scliar, Marilia O., Nunes, Kelly, Passos-Bueno, Maria Rita, Castelli, Erick C., Magawa, Jhosiene Y., Adami, Flávia L., Moretti, Ana I. S., de Oliveira, Vivian L., Boscardin, Silvia B., Cunha-Neto, Edecio, Kalil, Jorge, Jouanguy, Emmanuelle, Bastard, Paul, Casanova, Jean-Laurent, Quiñones-Vega, Mauricio, Sosa-Acosta, Patricia, Guedes, Jéssica de S., de Almeida, Natália P., Nogueira, Fábio C. S., Domont, Gilberto B., Santos, Keity S., and Zatz, Mayana

Published
2022
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5. The oldest unvaccinated Covid-19 survivors in South America

Author

de Castro, Mateus V., Silva, Monize V. R., Naslavsky, Michel S., Scliar, Marilia O., Nunes, Kelly, Passos-Bueno, Maria Rita, Castelli, Erick C., Magawa, Jhosiene Y., Adami, Flávia L., Moretti, Ana I. S., de Oliveira, Vivian L., Boscardin, Silvia B., Cunha-Neto, Edecio, Kalil, Jorge, Jouanguy, Emmanuelle, Bastard, Paul, Casanova, Jean-Laurent, Quiñones-Vega, Mauricio, Sosa-Acosta, Patricia, Guedes, Jéssica de S., de Almeida, Natália P., Nogueira, Fábio C. S., Domont, Gilberto B., Santos, Keity S., and Zatz, Mayana

Published
2022
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7. Anti-RBD IgG antibodies from endemic coronaviruses do not protect against the acquisition of SARS-CoV-2 infection among exposed uninfected individuals

Author

Adami, Flávia Lopes, primary, de Castro, Mateus Vidigal, additional, Almeida, Bianca da Silva, additional, Daher, Isabela Pazotti, additional, Yamamoto, Márcio Massao, additional, Souza Santos, Keity, additional, Zatz, Mayana, additional, Naslavsky, Michel Satya, additional, Rosa, Daniela Santoro, additional, Cunha-Neto, Edecio, additional, de Oliveira, Vivian Leite, additional, Kalil, Jorge, additional, and Boscardin, Silvia Beatriz, additional

Published
2024
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8. A refined genome phage display methodology delineates the human antibody response in patients with Chagas disease

Author

Teixeira, André Azevedo Reis, Carnero, Luis Rodriguez, Kuramoto, Andréia, Tang, Fenny Hui Fen, Gomes, Carlos Hernique, Pereira, Natalia Bueno, de Oliveira, Léa Campos, Garrini, Regina, Monteiro, Jhonatas Sirino, Setubal, João Carlos, Sabino, Ester Cerdeira, Pasqualini, Renata, Colli, Walter, Arap, Wadih, Alves, Maria Júlia Manso, Cunha-Neto, Edécio, and Giordano, Ricardo José

Published
2021
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9. Blood Gene Signatures of Chagas Cardiomyopathy With or Without Ventricular Dysfunction

Author

Ferreira, Ludmila Rodrigues Pinto, Ferreira, Frederico Moraes, Nakaya, Helder Imoto, Deng, Xutao, da Silva Cândido, Darlan, de Oliveira, Lea Campos, Billaud, Jean-Noel, Lanteri, Marion C, Rigaud, Vagner Oliveira-Carvalho, Seielstad, Mark, Kalil, Jorge, Fernandes, Fabio, Ribeiro, Antonio Luiz P, Sabino, Ester Cerdeira, and Cunha-Neto, Edecio

Subjects
Vector-Borne Diseases, Heart Disease, Rare Diseases, Cardiovascular, Clinical Research, Human Genome, Genetics, Infectious Diseases, 2.1 Biological and endogenous factors, Aetiology, Good Health and Well Being, CD8-Positive T-Lymphocytes, Chagas Cardiomyopathy, Cytotoxicity, Immunologic, Gene Expression Profiling, Gene Regulatory Networks, Humans, Killer Cells, Natural, Microarray Analysis, Middle Aged, Myocardium, Real-Time Polymerase Chain Reaction, Ventricular Dysfunction, Chagas disease, whole-blood transcriptome, Cardiomyopathy, NK cells, NK cells., Biological Sciences, Medical and Health Sciences, Microbiology
Abstract

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, affects 7 million people in Latin American areas of endemicity. About 30% of infected patients will develop chronic Chagas cardiomyopathy (CCC), an inflammatory cardiomyopathy characterized by hypertrophy, fibrosis, and myocarditis. Further studies are necessary to understand the molecular mechanisms of disease progression. Transcriptome analysis has been increasingly used to identify molecular changes associated with disease outcomes. We thus assessed the whole-blood transcriptome of patients with Chagas disease. Microarray analysis was performed on blood samples from 150 subjects, of whom 30 were uninfected control patients and 120 had Chagas disease (1 group had asymptomatic disease, and 2 groups had CCC with either a preserved or reduced left ventricular ejection fraction [LVEF]). Each Chagas disease group displayed distinct gene expression and functional pathway profiles. The most different expression patterns were between CCC groups with a preserved or reduced LVEF. A more stringent analysis indicated that 27 differentially expressed genes, particularly those related to natural killer (NK)/CD8+ T-cell cytotoxicity, separated the 2 groups. NK/CD8+ T-cell cytotoxicity could play a role in determining Chagas disease progression. Understanding genes associated with disease may lead to improved insight into CCC pathogenesis and the identification of prognostic factors for CCC progression.

Published
2017

10. Correction: p16INK4a Expression and Immunologic Aging in Chronic HIV Infection

Author

Ribeiro, Susan Pereira, Milush, Jeffrey M, Cunha-Neto, Edecio, Kallas, Esper G, Kalil, Jorge, Passero, Luiz Felipe D, Hunt, Peter W, Deeks, Steven G, Nixon, Douglas F, and SenGupta, Devi

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, HIV/AIDS, Aging, Sexually Transmitted Infections, Infectious Diseases, Good Health and Well Being, General Science & Technology
Abstract

[This corrects the article DOI: 10.1371/journal.pone.0166759.].

Published
2017

11. Rare Pathogenic Variants in Mitochondrial and Inflammation-Associated Genes May Lead to Inflammatory Cardiomyopathy in Chagas Disease

Author

Ouarhache, Maryem, Marquet, Sandrine, Frade, Amanda Farage, Ferreira, Ariela Mota, Ianni, Barbara, Almeida, Rafael Ribeiro, Nunes, Joao Paulo Silva, Ferreira, Ludmila Rodrigues Pinto, Rigaud, Vagner Oliveira-Carvalho, Cândido, Darlan, Mady, Charles, Zaniratto, Ricardo Costa Fernandes, Buck, Paula, Torres, Magali, Gallardo, Frederic, Andrieux, Pauline, Bydlowsky, Sergio, Levy, Debora, Abel, Laurent, Cardoso, Clareci Silva, Santos-Junior, Omar Ribeiro, Oliveira, Lea Campos, Oliveira, Claudia Di Lorenzo, Nunes, Maria Do Carmo, Cobat, Aurelie, Kalil, Jorge, Ribeiro, Antonio Luiz, Sabino, Ester Cerdeira, Cunha-Neto, Edecio, and Chevillard, Christophe

Published
2021
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12. Post-COVID-19 condition: systemic inflammation and low functional exercise capacity

Author

de Castro, Gabriela Salim, primary, Gama, Leonardo R., additional, Ramos, Alexandre Ferreira, additional, Gatti da Silva, Guilherme, additional, Teixeira, Alexandre Abilio de Souza, additional, Cunha-Neto, Edecio, additional, de Souza, Heraldo Possolo, additional, Marie, Suely K., additional, Talib, Leda L., additional, Coelho, Verônica, additional, Kalil, Jorge, additional, de Araujo, Adriana Ladeira, additional, Ritto, Ana Paula, additional, Belon, Alessandro Rodrigo, additional, Santos, Amanda Soares, additional, Barrére, Ana Paula Noronha, additional, Sawamura, Márcio V. Y., additional, Lamas, Celina Almeida, additional, Baldi, Bruno Guedes, additional, Carvalho, Carlos R. R., additional, Kulikowski, Leslie Domenici, additional, Damiano, Rodolfo Furlan, additional, Imamura, Marta, additional, Rosa Neto, José Cesar, additional, Lira, Fabio S., additional, Otoch, José Pinhata, additional, Miguel, Euripedes Constantino, additional, Battistella, Linamara, additional, Forlenza, Orestes V., additional, Busatto, Geraldo, additional, and Seelaender, Marilia, additional

Published
2024
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15. p16INK4a Expression and Immunologic Aging in Chronic HIV Infection

Author

Ribeiro, Susan Pereira, Milush, Jeffrey M, Cunha-Neto, Edecio, Kallas, Esper G, Kalil, Jorge, Passero, Luiz Felipe D, Hunt, Peter W, Deeks, Steven G, Nixon, Douglas F, and SenGupta, Devi

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, HIV/AIDS, Clinical Research, Sexually Transmitted Infections, Aging, Infectious Diseases, 2.1 Biological and endogenous factors, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Aetiology, Inflammatory and immune system, Infection, Good Health and Well Being, General Science & Technology
Abstract

Chronic HIV infection is characterized by increased immune activation and immunosenescence. p16 INK4a (p16) is a member of the cyclin-dependent kinase antagonist family that inhibits cellular proliferation, and its protein expression increases during normal chronological aging. However, some infectious diseases can increase the expression of this anti-proliferative protein, potentially accelerating immunological aging and dysfunction. In order to investigate the immunological aging in HIV patients, p16 protein expression was evaluated by flow cytometry, in T cell subsets in a cohort of chronically HIV-infected patients on and off ART as well as age-matched healthy controls. Results showed that untreated HIV-infected subjects exhibited increased per-cell p16 protein expression that was discordant with chronological aging. ART restored p16 protein expression to levels comparable with HIV-negative subjects in the CD4 compartment, but not in CD8 T cells, which can be an indicative of an irreversible activation/exhaustion status on these cells. Additionally, the frequency of activated CD4+ and CD8+ T cells was positively correlated with p16 expression in CD4+ and CD8+ T cells in untreated subjects. In contrast to healthy controls, untreated HIV-infected individuals had increased p16 levels within the effector memory (TEM) subset, indicating a possible role for this marker in impaired clonal expansion during antiviral effector function. Taken together, these data demonstrate that chronic HIV infection is associated with elevated expression of the cellular aging marker p16 in T cells. ART restored normal p16 levels in the CD4+ T cell compartment, indicating that use of therapy can be of fundamental importance to normal cell cycling and maintaining immune homeostasis.

Published
2016

16. Prolonged dipyridamole administration reduces myocardial perfusion defects in experimental chronic Chagas cardiomyopathy

Author

Tanaka, Denise Mayumi, de Oliveira, Luciano Fonseca Lemos, Marin-Neto, José Antônio, Romano, Minna Moreira Dias, de Carvalho, Eduardo Elias Vieira, de Barros Filho, Antonio Carlos Leite, Ribeiro, Fernando Fonseca França, Cabeza, Jorge Mejia, Lopes, Carla Duque, Fabricio, Camila Godoy, Kesper, Norival, Moreira, Henrique Turin, Wichert-Ana, Lauro, Schmidt, André, Higuchi, Maria de Lourdes, Cunha-Neto, Edécio, and Simões, Marcus Vinícius

Published
2019
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19. The CD8+ Memory Stem T Cell (TSCM) Subset Is Associated with Improved Prognosis in Chronic HIV-1 Infection

Author

Ribeiro, Susan P, Milush, Jeffrey M, Cunha-Neto, Edecio, Kallas, Esper G, Kalil, Jorge, Somsouk, Ma, Hunt, Peter W, Deeks, Steven G, Nixon, Douglas F, and SenGupta, Devi

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Regenerative Medicine, Immunization, Stem Cell Research, Sexually Transmitted Infections, HIV/AIDS, Vaccine Related, Clinical Research, Infectious Diseases, 2.2 Factors relating to the physical environment, Aetiology, 2.1 Biological and endogenous factors, Infection, Inflammatory and immune system, Good Health and Well Being, Adult, Antiretroviral Therapy, Highly Active, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Cohort Studies, Cross-Sectional Studies, Female, HIV Infections, HIV-1, Humans, Immunologic Memory, Male, Middle Aged, Prognosis, Stem Cells, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Virology, Agricultural, veterinary and food sciences, Biological sciences, Biomedical and clinical sciences
Abstract

UnlabelledMemory stem T cells (T(SCM)) constitute a long-lived, self-renewing lymphocyte population essential for the maintenance of functional immunity. The hallmarks of HIV-1 pathogenesis are CD4(+) T cell depletion and abnormal cellular activation. We investigated the impact of HIV-1 infection on the T(SCM) compartment, as well as any protective role these cells may have in disease progression, by characterizing this subset in a cohort of 113 subjects with various degrees of viral control on and off highly active antiretroviral therapy (HAART). We observed that the frequency of CD8(+) T(SCM) was decreased in all individuals with chronic, untreated HIV-1 infection and that HAART had a restorative effect on this subset. In contrast, natural controllers of HIV-1 had the highest absolute number of CD4(+) T(SCM) cells among all of the infected groups. The frequency of CD4(+) T(SCM) predicted higher CD8(+) T(SCM) frequencies, consistent with a role for the CD4(+) subset in helping to maintain CD8(+) memory T cells. In addition, T(SCM) appeared to be progenitors for effector T cells (TEM), as these two compartments were inversely correlated. Increased frequencies of CD8(+) T(SCM) predicted lower viral loads, higher CD4(+) counts, and less CD8(+) T cell activation. Finally, we found that T(SCM) express the mucosal homing integrin α4β7 and can be identified in gut-associated lymphoid tissue (GALT). The frequency of mucosal CD4(+) T(SCM) was inversely correlated with that in the blood, potentially reflecting the ability of these self-renewing cells to migrate to a crucial site of ongoing viral replication and CD4(+) T cell depletion.ImportanceHIV-1 infection leads to profound impairment of the immune system. T(SCM) constitute a recently identified lymphocyte subset with stem cell-like qualities, including the ability to generate other memory T cell subtypes, and are therefore likely to play an important role in controlling viral infection. We investigated the relationship between the size of the CD8(+) T(SCM) compartment and HIV-1 disease progression in a cohort of chronically infected individuals. Our results suggest that HAART restores a normal frequency of CD8(+) T(SCM) and that the natural preservation of this subset in the setting of untreated HIV-1 infection is associated with improved viral control and immunity. Therefore, the CD8(+) T(SCM) population may represent a correlate of protection in chronic HIV-1 infection that is directly relevant to the design of T cell-based vaccines, adoptive immunotherapy approaches, or the pharmacologic induction of T(SCM).

Published
2014

20. Anti-RBD IgG antibodies from endemic coronaviruses do not protect against the acquisition of SARS-CoV-2 infection among exposed uninfected individuals.

Author

Lopes Adami, Flávia, de Castro, Mateus Vidigal, da Silva Almeida, Bianca, Pazotti Daher, Isabela, Massao Yamamoto, Márcio, Santos, Keity Souza, Zatz, Mayana, Satya Naslavsky, Michel, Santoro Rosa, Daniela, Cunha-Neto, Edecio, Leite de Oliveira, Vivian, Kalil, Jorge, and Boscardin, Silvia Beatriz

Subjects
MIDDLE East respiratory syndrome, SARS-CoV-2, CORONAVIRUS diseases, CORONAVIRUSES, IMMUNOGLOBULIN G, ENDEMIC diseases
Abstract

Background: The Coronaviridae family comprises seven viruses known to infect humans, classified into alphacoronaviruses (HCoV-229E and HCoV-NL63) and betacoronaviruses (HCoV-OC43 and HCoV-HKU1), which are considered endemic. Additionally, it includes SARS-CoV (severe acute respiratory syndrome), MERS-CoV (Middle East respiratory syndrome), and the novel coronavirus SARSCoV- 2, responsible for COVID-19. SARS-CoV-2 induces severe respiratory complications, particularly in the elderly, immunocompromised individuals and those with underlying diseases. An essential question since the onset of the COVID-19 pandemic has been to determine whether prior exposure to seasonal coronaviruses influences immunity or protection against SARS-CoV-2. Methods: In this study, we investigated a cohort of 47 couples (N=94), where one partner tested positive for SARS-CoV-2 infection via real-time PCR while the other remained negative. Plasma samples, collected at least 30 days post-PCR reaction, were assessed using indirect ELISA and competition assays to measure specific antibodies against the receptor-binding domain (RBD) portion of the Spike (S) protein from SARS-CoV-2, HCoV-229E, HCoV-NL63, HCoV-OC43, and HCoV-HKU1. Results: IgG antibody levels against the four endemic coronavirus RBD proteins were similar between the PCR-positive and PCR-negative individuals, suggesting that IgG against endemic coronavirus RBD regions was not associated with protection from infection. Moreover, we found no significant IgG antibody crossreactivity between endemic coronaviruses and SARS-CoV-2 RBDs. Conclusions: Taken together, results suggest that anti-RBD antibodies induced by a previous infection with endemic HCoVs do not protect against acquisition of COVID-19 among exposed uninfected individuals. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Parasite DNA and Markers of Decreased Immune Activation Associate Prospectively with Cardiac Functional Decline over 10 Years among Trypanosoma cruzi Seropositive Individuals in Brazil

Author

Sunderraj, Ashwin, primary, Cunha, Luisa Marin, additional, Avila, Matheus, additional, Alexandria, Shaina, additional, Ferreira, Ariela Mota, additional, de Oliveira-da Silva, Léa Campos, additional, Ribeiro, Antonio L. P., additional, Nunes, Maria do Carmo Pereira, additional, Sabino, Ester C., additional, Landay, Alan, additional, Kalil, Jorge, additional, Chevillard, Christophe, additional, Cunha-Neto, Edecio, additional, and Feinstein, Matthew J., additional

Published
2023
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23. Mitochondrial DNA Haplogroups and Variants Predispose to Chagas Disease Cardiomyopathy

Author

Gallardo, Frédéric, primary, Brochet, Pauline, additional, Goudenège, David, additional, Nunes, João Paulo Silva, additional, Andrieux, Pauline, additional, Ianni, Barbara Maria, additional, Frade, Amanda Farage, additional, Mady, Charles, additional, Santos, Ronaldo Honorato Barros, additional, Kuramoto, Andreia, additional, Steffen, Samuel, additional, Stolf, Antonio Noedir, additional, Pomerantzeff, Pablo, additional, Fiorelli, Alfredo Inacio, additional, Bocchi, Edimar Alcides, additional, Pissetti, Cristina Wide, additional, Saba, Bruno, additional, Dias, Fabrício C., additional, Sampaio, Marcelo Ferraz, additional, Gaiotto, Fabio Antônio, additional, Marin-Neto, José Antonio, additional, Fragata, Abílio, additional, Zaniratto, Ricardo Costa Fernandes, additional, Siqueira, Sergio, additional, Peixoto, Giselle De Lima, additional, Bacal, Fernando, additional, Buck, Paula, additional, Almeida, Rafael Ribeiro, additional, Lin-Wang, Hui Tzu, additional, Schmidt, André, additional, Hirata, Mario Hiroyuki, additional, Donadi, Eduardo Antonio, additional, Pereira, Alexandre Costa, additional, Rodrigues Junior, Virmondes, additional, Martinelli, Martino, additional, Naslavsky, Michel, additional, Kalil, Jorge, additional, Procaccio, Vincent, additional, Cunha-Neto, Edecio, additional, and Chevillard, Christophe, additional

Published
2023
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25. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.

Author

Deng, Xutao, Sabino, Ester, Cunha-Neto, Edecio, Ribeiro, Antonio, Ianni, Barbara, Mady, Charles, Busch, Michael, and Seielstad, Mark

Subjects
Chagas Cardiomyopathy, Female, Genome-Wide Association Study, Genotype, Humans, Male, Phenotype, Polymorphism, Single Nucleotide, Retrospective Studies, Trypanosoma cruzi
Abstract

BACKGROUND: Familial aggregation of Chagas cardiac disease in T. cruzi-infected persons suggests that human genetic variation may be an important determinant of disease progression. OBJECTIVE: To perform a GWAS using a well-characterized cohort to detect single nucleotide polymorphisms (SNPs) and genes associated with cardiac outcomes. METHODS: A retrospective cohort study was developed by the NHLBI REDS-II program in Brazil. Samples were collected from 499 T. cruzi seropositive blood donors who had donated between 1996 and 2002, and 101 patients with clinically diagnosed Chagas cardiomyopathy. In 2008-2010, all subjects underwent a complete medical examination. After genotype calling, quality control filtering with exclusion of 20 cases, and imputation of 1,000 genomes variants; association analysis was performed for 7 cardiac and parasite related traits, adjusting for population stratification. RESULTS: The cohort showed a wide range of African, European, and modest Native American admixture proportions, consistent with the recent history of Brazil. No SNPs were found to be highly (P

Published
2013

27. Whole-Genome Cardiac DNA Methylation Fingerprint and Gene Expression Analysis Provide New Insights in the Pathogenesis of Chronic Chagas Disease Cardiomyopathy

Author

Laugier, Laurie, Frade, Amanda Farage, Ferreira, Frederico Moraes, Baron, Monique Andrade, Teixeira, Priscila Camillo, Cabantous, Sandrine, Ferreira, Ludmila Rodrigues Pinto, Louis, Laurence, Rigaud, Vagner Oliveira Carvalho, Gaiotto, Fabio Antonio, Bacal, Fernando, Pomerantzeff, Pablo, Bocchi, Edimar, Kalil, Jorge, Santos, Ronaldo Honorato Barros, Cunha-Neto, Edecio, and Chevillard, Christophe

Published
2017

28. Post-COVID-19 condition: systemic inflammation and low functional exercise capacity.

Author

Salim de Castro, Gabriela, Gama, Leonardo R., Ferreira Ramos, Alexandre, Gatti da Silva, Guilherme, de Souza Teixeira, Alexandre Abilio, Cunha-Neto, Edecio, Possolo de Souza, Heraldo, Marie, Suely K., Talib, Leda L., Coelho, Verônica, Kalil, Jorge, Ladeira de Araujo, Adriana, Paula Ritto, Ana, Rodrigo Belon, Alessandro, Soares Santos, Amanda, Noronha Barrére, Ana Paula, Sawamura, Márcio V. Y., Almeida Lamas, Celina, Guedes Baldi, Bruno, and Carvalho, Carlos R. R.

Published
2024
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29. Parasite DNA and Markers of Decreased Immune Activation Associate Prospectively with Cardiac Functional Decline over 10 Years among Trypanosoma cruzi Seropositive Individuals in Brazil.

Author

Sunderraj, Ashwin, Cunha, Luisa Marin, Avila, Matheus, Alexandria, Shaina, Ferreira, Ariela Mota, de Oliveira-da Silva, Léa Campos, Ribeiro, Antonio L. P., Nunes, Maria do Carmo Pereira, Sabino, Ester C., Landay, Alan, Kalil, Jorge, Chevillard, Christophe, Cunha-Neto, Edecio, and Feinstein, Matthew J.

Subjects
GENETIC markers, BIOMARKERS, TRYPANOSOMA cruzi, TUMOR necrosis factors, VENTRICULAR ejection fraction
Abstract

Parasitemia and inflammatory markers are cross-sectionally associated with chronic Chagas cardiomyopathy (CCC) among patients with Trypanosoma cruzi. However, the prospective association of the parasite load and host immune response-related characteristics with CCC (that is, progressors) among T. cruzi seropositive individuals has only been partially defined. In a cohort of T. cruzi seropositive patients in Montes Claros and São Paulo, Brazil who were followed over 10 years, we identified the association of a baseline T. cruzi parasite load and systemic markers of inflammation with a decline in cardiac function and/or the presence of cardiac congestion 10 years later. The progressors (n = 21) were individuals with a significant decline in the left ventricular ejection fraction and/or elevated markers of cardiac congestion after 10 years. The controls (n = 31) had normal markers of cardiac function and congestion at the baseline and at the follow-up. They were matched with the progressors on age, sex, and genetic ancestry. The progressors had higher mean parasite loads at the baseline than the controls (18.3 vs. 0.605 DNA parasite equivalents/20 mL, p < 0.05). Of the 384 inflammation-related proteins analyzed, 47 differed significantly at a false discovery rate- (FDR-) corrected p < 0.05 between the groups. There were 44 of these 47 proteins that were significantly higher in the controls compared to in the progressors, including the immune activation markers CCL21, CXCL12, and HCLS1 and several of the tumor necrosis factor superfamily of proteins. Among the individuals who were seropositive for T. cruzi at the baseline and who were followed over 10 years, those with incident CCC at the 10-year marker had a comparatively higher baseline of T. cruzi parasitemia and lower baseline markers of immune activation and chemotaxis. These findings generate the hypothesis that the early impairment of pathogen-killing immune responses predisposes individuals to CCC, which merits further study. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Myocardial Infarction–Associated Transcript, a Long Noncoding RNA, Is Overexpressed During Dilated Cardiomyopathy Due to Chronic Chagas Disease

Author

Frade, Amanda Farage, Laugier, Laurie, Ferreira, Ludmila Rodrigues Pinto, Baron, Monique Andrade, Benvenuti, Luiz Alberto, Teixeira, Priscila Camillo, Navarro, Isabela Cunha, Cabantous, Sandrine, Ferreira, Frederico Moraes, da Silva Cândido, Darlan, Gaiotto, Fabio Antônio, Bacal, Fernando, Pomerantzeff, Pablo, Santos, Ronaldo Honorato Barros, Kalil, Jorge, Cunha-Neto, Edecio, and Chevillard, Christophe

Published
2016

33. Immune Responses Of CVID Patients To COVID-19 Vaccines

Author

Xavier de Medeiros, Giuliana, primary, de Carvalho Pereira Ferreira, Loisi, additional, Magawa, Jhosiene Yukari, additional, Kuramoto, Andréia, additional, Sasahara, Greyce Luri, additional, Ferreira, Marcelo, additional, Toledo Barros, Myrthes Maragna, additional, Kalil, Jorge, additional, Barreto Berselli Marinho, Ana Karolina, additional, Cunha-Neto, Edecio, additional, Santos, Keity Souza, additional, and Kokron, Cristina, additional

Published
2023
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34. Immunodominant antibody responses directed to SARS-CoV-2 hotspot mutation sites and risk of immune escape

Author

Oliveira, Jamille Ramos, primary, Ruiz, Cesar Manuel Remuzgo, additional, Machado, Rafael Rahal Guaragna, additional, Magawa, Jhosiene Yukari, additional, Daher, Isabela Pazotti, additional, Urbanski, Alysson Henrique, additional, Schmitz, Gabriela Justamante Händel, additional, Arcuri, Helen Andrade, additional, Ferreira, Marcelo Alves, additional, Sasahara, Greyce Luri, additional, de Medeiros, Giuliana Xavier, additional, Júnior, Roberto Carlos Vieira Silva, additional, Durigon, Edison Luiz, additional, Boscardin, Silvia Beatriz, additional, Rosa, Daniela Santoro, additional, Schechtman, Deborah, additional, Nakaya, Helder I., additional, Cunha-Neto, Edecio, additional, Gadermaier, Gabriele, additional, Kalil, Jorge, additional, Coelho, Verônica, additional, and Santos, Keity Souza, additional

Published
2023
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35. Diretriz da SBC sobre Diagnóstico e Tratamento de Pacientes com Cardiomiopatia da Doença de Chagas – 2023

Author

Marin-Neto, José Antonio, primary, Rassi, Anis, additional, Oliveira, Gláucia Maria Moraes, additional, Correia, Luís Claudio Lemos, additional, Ramos, Alberto Novaes, additional, Luquetti, Alejandro Ostermayer, additional, Hasslocher-Moreno, Alejandro Marcel, additional, Sousa, Andréa Silvestre de, additional, Paola, Angelo Amato Vincenzo de, additional, Sousa, Antônio Carlos Sobral, additional, Ribeiro, Antonio Luiz Pinho, additional, Correia, Dalmo, additional, Souza, Dilma do Socorro Moraes de, additional, Cunha-Neto, Edecio, additional, Ramires, Felix Jose Alvarez, additional, Bacal, Fernando, additional, Nunes, Maria do Carmo Pereira, additional, Martinelli, Martino, additional, Scanavacca, Maurício Ibrahim, additional, Saraiva, Roberto Magalhães, additional, Oliveira, Wilson Alves de, additional, Lorga-Filho, Adalberto Menezes, additional, Guimarães, Adriana de Jesus Benevides de Almeida, additional, Braga, Adriana Lopes Latado, additional, Oliveira, Adriana Sarmento de, additional, Sarabanda, Alvaro Valentim Lima, additional, Pinto, Ana Yecê das Neves, additional, Carmo, Andre Assis Lopes do, additional, Schmidt, Andre, additional, Costa, Andréa Rodrigues da, additional, Ianni, Barbara Maria, additional, Markman, Brivaldo, additional, Rochitte, Carlos Eduardo, additional, Macêdo, Carolina Thé, additional, Mady, Charles, additional, Chevillard, Christophe, additional, Virgens, Cláudio Marcelo Bittencourt das, additional, Castro, Cleudson Nery de, additional, Britto, Constança Felicia De Paoli de Carvalho, additional, Pisani, Cristiano, additional, Rassi, Daniela do Carmo, additional, Sobral, Dário Celestino, additional, Almeida, Dirceu Rodrigues de, additional, Bocchi, Edimar Alcides, additional, Mesquita, Evandro Tinoco, additional, Mendes, Fernanda de Souza Nogueira Sardinha, additional, Gondim, Francisca Tatiana Pereira, additional, Silva, Gilberto Marcelo Sperandio da, additional, Peixoto, Giselle de Lima, additional, Lima, Gustavo Glotz de, additional, Veloso, Henrique Horta, additional, Moreira, Henrique Turin, additional, Lopes, Hugo Bellotti, additional, Pinto, Ibraim Masciarelli Francisco, additional, Ferreira, João Marcos Bemfica Barbosa, additional, Nunes, João Paulo Silva, additional, Barreto-Filho, José Augusto Soares, additional, Saraiva, José Francisco Kerr, additional, Lannes-Vieira, Joseli, additional, Oliveira, Joselina Luzia Menezes, additional, Armaganijan, Luciana Vidal, additional, Martins, Luiz Cláudio, additional, Sangenis, Luiz Henrique Conde, additional, Barbosa, Marco Paulo Tomaz, additional, Almeida-Santos, Marcos Antonio, additional, Simões, Marcos Vinicius, additional, Yasuda, Maria Aparecida Shikanai, additional, Moreira, Maria da Consolação Vieira, additional, Higuchi, Maria de Lourdes, additional, Monteiro, Maria Rita de Cassia Costa, additional, Mediano, Mauro Felippe Felix, additional, Lima, Mayara Maia, additional, Oliveira, Maykon Tavares de, additional, Romano, Minna Moreira Dias, additional, Araujo, Nadjar Nitz Silva Lociks de, additional, Medeiros, Paulo de Tarso Jorge, additional, Alves, Renato Vieira, additional, Teixeira, Ricardo Alkmim, additional, Pedrosa, Roberto Coury, additional, Aras, Roque, additional, Torres, Rosalia Morais, additional, Povoa, Rui Manoel dos Santos, additional, Rassi, Sergio Gabriel, additional, Alves, Silvia Marinho Martins, additional, Tavares, Suelene Brito do Nascimento, additional, Palmeira, Swamy Lima, additional, Silva, Telêmaco Luiz da, additional, Rodrigues, Thiago da Rocha, additional, Madrini, Vagner, additional, Brant, Veruska Maia da Costa, additional, Dutra, Walderez Ornelas, additional, and Dias, João Carlos Pinto, additional

Published
2023
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37. Drug Repurposing in Chagas Disease: Chloroquine Potentiates Benznidazole Activity against Trypanosoma cruzi In Vitro and In Vivo

Author

Pandey, Ramendra P., primary, Nascimento, Marilda Savoia, additional, Franco, Caio Haddad, additional, Bortoluci, Karina, additional, Silva, Marcelo Nunes, additional, Zingales, Bianca, additional, Gibaldi, Daniel, additional, Castaño Barrios, Leda, additional, Lannes-Vieira, Joseli, additional, Cariste, Leonardo Moro, additional, Vasconcelos, Jose Ronnie, additional, Moraes, Carolina Borsoi, additional, Freitas-Junior, Lucio H., additional, Kalil, Jorge, additional, Alcântara, Laura, additional, and Cunha-Neto, Edecio, additional

Published
2022
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38. MUC22, HLA-A, and HLA-DOB variants and COVID-19 in resilient super-agers from Brazil

Author

Castelli, Erick C., primary, de Castro, Mateus V., additional, Naslavsky, Michel S., additional, Scliar, Marilia O., additional, Silva, Nayane S. B., additional, Pereira, Raphaela N., additional, Ciriaco, Viviane A. O., additional, Castro, Camila F. B., additional, Mendes-Junior, Celso T., additional, Silveira, Etiele de S., additional, de Oliveira, Iuri M., additional, Antonio, Eduardo C., additional, Vieira, Gustavo F., additional, Meyer, Diogo, additional, Nunes, Kelly, additional, Matos, Larissa R. B., additional, Silva, Monize V. R., additional, Wang, Jaqueline Y. T., additional, Esposito, Joyce, additional, Cória, Vivian R., additional, Magawa, Jhosiene Y., additional, Santos, Keity S., additional, Cunha-Neto, Edecio, additional, Kalil, Jorge, additional, Bortolin, Raul H., additional, Hirata, Mário Hiroyuki, additional, Dell’Aquila, Luiz P., additional, Razuk-Filho, Alvaro, additional, Batista-Júnior, Pedro B., additional, Duarte-Neto, Amaro N., additional, Dolhnikoff, Marisa, additional, Saldiva, Paulo H. N., additional, Passos-Bueno, Maria Rita, additional, and Zatz, Mayana, additional

Published
2022
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39. Diretriz da Sociedade Brasileira de Cardiologia sobre Diagnóstico e Tratamento de Pacientes com Cardiomiopatia da Doença de Chagas

Author

Marin-Neto, José Antonio, primary, Rassi Jr., Anis, additional, Moraes Oliveira, Gláucia M., additional, Lemos Correia, Luís Claudio, additional, Novaes Ramos Jr., Alberto, additional, Hasslocher-Moreno, Alejandro Marcel, additional, Luquetti Ostermayer, Alejandro, additional, Sousa, Andréa Silvestre de, additional, Amato Vincenzo de Paola, Angelo, additional, Sobral de Sousa, Antonio Carlos, additional, Pinho Ribeiro, Antonio Luiz, additional, Correia Filho, Dalmo, additional, Moraes de Souza, Dilma do Socorro, additional, Cunha-Neto, Edecio, additional, J. A. Ramires, Felix, additional, Bacal, Fernando, additional, Pereira Nunes, Maria do Carmo, additional, Martinelli Filho, Martino, additional, Ibrahim Scanavacca, Maurício, additional, Magalhães Saraiva, Roberto, additional, Alves de Oliveira Júnior, Wilson, additional, M. Lorga-Filho, Adalberto, additional, De Jesus Benevides de Almeida Guimarães, Adriana, additional, Lopes Latado Braga, Adriana, additional, Sarmento de Oliveira, Adriana, additional, V. L. Sarabanda, Alvaro, additional, Yecê das Neves Pinto, Ana, additional, Assis Lopes do Carmo, André, additional, Schmidt, André, additional, Costa, Andréa Rodrigues da, additional, Ianni, Barbara Maria, additional, Markman Filho, Brivaldo, additional, Eduardo Rochitte, Carlos, additional, Thé Macedo, Carolina, additional, Mady, Charles, additional, Chevillard, Christophe, additional, Bittencourt das Virgens, Cláudio Marcelo, additional, Nery de Castro, Cleudson, additional, De Paoli de Carvalho Britto, Constança Felícia, additional, Pisani, Cristiano, additional, Do Carmo Rassi, Daniela, additional, C. Sobral Filho, Dario, additional, Rodrigues Almeida, Dirceu, additional, A. Bocchi, Edimar, additional, T. Mesquita, Evandro, additional, De Souza Nogueira Sardinha Mendes, Fernanda, additional, Pereira, Francisca Tatiana, additional, Sperandio da Silva, Gilberto Marcelo, additional, De Lima Peixoto, Giselle, additional, Glotz de Lima, Gustavo, additional, H. Veloso, Henrique, additional, Turin Moreira, Henrique, additional, Bellotti Lopes, Hugo, additional, Masciarelli Francisco Pinto, Ibraim, additional, Pinto Dias, João Carlos, additional, Bemfica, João Marcos, additional, Silva-Nunes, João Paulo, additional, Soares Barreto-Filho, José Augusto, additional, Kerr Saraiva, José Francisco, additional, Lannes-Vieira, Joseli, additional, Menezes Oliveira, Joselina Luzia, additional, V. Armaganijan, Luciana, additional, Martins, Luiz Cláudio, additional, C. Sangenis, Luiz Henrique, additional, Barbosa, Marco Paulo, additional, Almeida-Santos, Marcos Antônio, additional, Simões, Marcos Vinicius, additional, Shikanai-Yasuda, Maria Aparecida, additional, Vieira Moreira, Maria da Consolação, additional, Higuchi, Maria de Lourdes, additional, Costa Monteiro, Maria Rita de Cássia, additional, Felix Mediano, Mauro Felippe, additional, Maia Lima, Mayara, additional, T. Oliveira, Maykon, additional, Moreira Dias Romano, Minna, additional, Nitz, Nadjar, additional, De Tarso Jorge Medeiros, Paulo, additional, Vieira Alves, Renato, additional, Alkmim Teixeira, Ricardo, additional, Coury Pedrosa, Roberto, additional, Aras, Roque, additional, Morais Torres, Rosália, additional, Dos Santos Povoa, Rui Manoel, additional, Rassi, Sérgio Gabriel, additional, Salles Xavier, Sérgio, additional, Marinho Martins Alves, Silvia, additional, B. N. Tavares, Suelene, additional, Lima Palmeira, Swamy, additional, Da Silva Junior, Telêmaco Luiz, additional, Da Rocha Rodrigues, Thiago, additional, Madrini Junior, Vagner, additional, Maia da Costa, Veruska, additional, and Dutra, Walderez, additional

Published
2022
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42. Follow-up of young adult monozygotic twins after simultaneous critical coronavirus disease 2019: a case report

Author

de Castro, Mateus V., primary, Silva, Monize V. R., additional, Soares, Flávia B., additional, Cória, Vivian R., additional, Naslavsky, Michel S., additional, Scliar, Marilia O., additional, Castelli, Erick C., additional, de Oliveira, Jamile R., additional, de Medeiros, Giuliana X., additional, Sasahara, Greyce L., additional, Santos, Keity S., additional, Cunha-Neto, Edecio, additional, Kalil, Jorge, additional, and Zatz, Mayana, additional

Published
2022
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43. Blood DNA methylation marks discriminate Chagas cardiomyopathy disease clinical forms

Author

Brochet, Pauline, primary, Ianni, Barbara, additional, Nunes, João P. S., additional, Frade, Amanda F., additional, Teixeira, Priscila C., additional, Mady, Charles, additional, Ferreira, Ludmila R. P., additional, Kuramoto, Andreia, additional, Pissetti, Cristina W., additional, Saba, Bruno, additional, Cândido, Darlan D. S., additional, Dias, Fabrício, additional, Sampaio, Marcelo, additional, Marin-Neto, José A., additional, Fragata, Abílio, additional, Zaniratto, Ricardo C .F., additional, Siqueira, Sergio, additional, Peixoto, Giselle D. L., additional, Rigaud, Vagner O. C., additional, Buck, Paula, additional, Almeida, Rafael R., additional, Lin-Wang, Hui Tzu, additional, Schmidt, André, additional, Martinelli, Martino, additional, Hirata, Mario H., additional, Donadi, Eduardo, additional, Rodrigues Junior, Virmondes, additional, Pereira, Alexandre C., additional, Kalil, Jorge, additional, Spinelli, Lionel, additional, Cunha-Neto, Edecio, additional, and Chevillard, Christophe, additional

Published
2022
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44. Chagas Disease Megaesophagus Patients Carrying Variant MRPS18B P260A Display Nitro-Oxidative Stress and Mitochondrial Dysfunction in Response to IFN-γ Stimulus

Author

Silva, Karla Deysiree Alcântara, primary, Nunes, João Paulo Silva, additional, Andrieux, Pauline, additional, Brochet, Pauline, additional, Almeida, Rafael Ribeiro, additional, Kuramoto Takara, Andréia Cristina Kazue, additional, Pereira, Natalia Bueno, additional, Abel, Laurent, additional, Cobat, Aurelie, additional, Zaniratto, Ricardo Costa Fernandes, additional, Levy, Débora, additional, Bydlowski, Sergio Paulo, additional, Cecconello, Ivan, additional, Seguro, Francisco Carlos Bernal da Costa, additional, Kalil, Jorge, additional, Chevillard, Christophe, additional, and Cunha-Neto, Edecio, additional

Published
2022
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45. Synonymous mutation rs1129293 is associated with PIK3CG expression and PI3Kγ activation in patients with chronic Chagas cardiomyopathy

Author

Silva, Maria Cláudia, primary, Fuzo, Carlos Alessandro, additional, Marques Paiva, Isadora, additional, Lopes Bibó, Naira, additional, Tavares de Oliveira, Maykon, additional, da Silva Soares, Hellen Anastácia, additional, Chevillard, Christophe, additional, Kalil, Jorge, additional, Cunha-Neto, Edecio, additional, Cunha, Thiago Mattar, additional, and Silva, João Santana, additional

Published
2022
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46. Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy

Author

Brochet, Pauline, primary, Ianni, Barbara Maria, additional, Laugier, Laurie, additional, Frade, Amanda Farage, additional, Silva Nunes, João Paulo, additional, Teixeira, Priscila Camillo, additional, Mady, Charles, additional, Ferreira, Ludmila Rodrigues Pinto, additional, Ferré, Quentin, additional, Santos, Ronaldo Honorato Barros, additional, Kuramoto, Andreia, additional, Cabantous, Sandrine, additional, Steffen, Samuel, additional, Stolf, Antonio Noedir, additional, Pomerantzeff, Pablo, additional, Fiorelli, Alfredo Inacio, additional, Bocchi, Edimar Alcides, additional, Pissetti, Cristina Wide, additional, Saba, Bruno, additional, Cândido, Darlan da Silva, additional, Dias, Fabrício C., additional, Sampaio, Marcelo Ferraz, additional, Gaiotto, Fabio Antônio, additional, Marin-Neto, José Antonio, additional, Fragata, Abílio, additional, Zaniratto, Ricardo Costa Fernandes, additional, Siqueira, Sergio, additional, Peixoto, Giselle De Lima, additional, Rigaud, Vagner Oliveira-Carvalho, additional, Bacal, Fernando, additional, Buck, Paula, additional, Almeida, Rafael Ribeiro, additional, Lin-Wang, Hui Tzu, additional, Schmidt, André, additional, Martinelli, Martino, additional, Hirata, Mario Hiroyuki, additional, Donadi, Eduardo Antonio, additional, Costa Pereira, Alexandre, additional, Rodrigues Junior, Virmondes, additional, Puthier, Denis, additional, Kalil, Jorge, additional, Spinelli, Lionel, additional, Cunha-Neto, Edecio, additional, and Chevillard, Christophe, additional

Published
2022
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47. Time-dependent contraction of the SARS-CoV-2–specific T-cell responses in convalescent individuals

Author

Fernandes, Edgar Ruz, primary, de Souza Apostolico, Juliana, additional, Jacintho, Lucas Cauê, additional, Carnevale Marin, Maria Lucia, additional, Vieira da Silva Júnior, Roberto Carlos, additional, Rodrigues, Hélcio, additional, Santos, Keity Souza, additional, Coelho, Verônica, additional, Boscardin, Silvia Beatriz, additional, Kalil, Jorge, additional, Cunha-Neto, Edecio, additional, and Rosa, Daniela Santoro, additional

Published
2022
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49. Cognitive impairment in long-COVID and its association with persistent dysregulation in inflammatory markers.

Author

Damiano, Rodolfo Furlan, de Almeida Rocca, Cristiana Castanho, de Pádua Serafim, Antonio, Loftis, Jennifer M., Talib, Leda Leme, Pan, Pedro Mário, Cunha-Neto, Edecio, Kalil, Jorge, de Castro, Gabriela Salim, Seelaender, Marilia, Guedes, Bruno F., Marie, Suely K. Nagahashi, de Souza, Heraldo Possolo, Nitrini, Ricardo, Miguel, Euripedes Constantino, Busatto, Geraldo, and Forlenza, Orestes V.

Subjects
POST-acute COVID-19 syndrome, COGNITION disorders, COVID-19, BLOOD diseases, COGNITIVE ability
Abstract

Objective: To analyze the potential impact of sociodemographic, clinical and biological factors on the long-term cognitive outcome of patients who survived moderate and severe forms of COVID-19. Methods: We assessed 710 adult participants (Mean age = 55 ± 14; 48.3% were female) 6 to 11 months after hospital discharge with a complete cognitive battery, as well as a psychiatric, clinical and laboratory evaluation. A large set of inferential statistical methods was used to predict potential variables associated with any long-term cognitive impairment, with a focus on a panel of 28 cytokines and other blood inflammatory and disease severity markers. Results: Concerning the subjective assessment of cognitive performance, 36.1% reported a slightly poorer overall cognitive performance, and 14.6% reported being severely impacted, compared to their pre-COVID-19 status. Multivariate analysis found sex, age, ethnicity, education, comorbidity, frailty and physical activity associated with general cognition. A bivariate analysis found that G-CSF, IFN-alfa2, IL13, IL15, IL1.RA, EL1.alfa, IL45, IL5, IL6, IL7, TNF-Beta, VEGF, Followup C-Reactive Protein, and Follow-up D-Dimer were significantly (p<.05) associated with general cognition. However, a LASSO regression that included all follow-up variables, inflammatory markers and cytokines did not support these findings. Conclusion: Though we identified several sociodemographic characteristics that might protect against cognitive impairment following SARS-CoV-2 infection, our data do not support a prominent role for clinical status (both during acute and long-stage of COVID-19) or inflammatory background (also during acute and long-stage of COVID-19) to explain the cognitive deficits that can follow COVID-19 infection. [ABSTRACT FROM AUTHOR]

Published
2023
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