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28 results on '"Cunha, Graccielle R."'

9. Identifying Depression Early in Adolescence: assessing the performance of a risk score for future onset of depression in an independent Brazilian sample

Author

Cunha, Graccielle R., primary, Caye, Arthur, additional, Pan, Pedro, additional, Fisher, Helen L., additional, Pereira, Rivka, additional, Ziebold, Carolina, additional, Bressan, Rodrigo, additional, Kohrt, Brandon A., additional, Mondelli, Valeria, additional, Kieling, Christian, additional, and Gadelha, Ary, additional

Published
2023
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10. Perinatal complications, lipid peroxidation, and mental health problems in a large community pediatric sample

Author

Mansur, Rodrigo B., Cunha, Graccielle R., Asevedo, Elson, Zugman, André, Rios, Adiel C., Salum, Giovanni A., Pan, Pedro M., Gadelha, Ary, Levandowski, Mateus L., Belangero, Síntia I., Manfro, Gisele G., Stertz, Laura, Kauer-Sant’anna, Márcia, Miguel, Eurípedes C., Bressan, Rodrigo A., Mari, Jair J., Grassi-Oliveira, Rodrigo, and Brietzke, Elisa

Published
2017
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11. Profile of Service Use and Barriers to Access to Care among Brazilian Children and Adolescents with Autism Spectrum Disorders

Author

Araripe, Beatriz, primary, Montiel-Nava, Cecilia, additional, Bordini, Daniela, additional, Cunha, Graccielle R., additional, Garrido, Gabriela, additional, Cukier, Sebastián, additional, Garcia, Ricardo, additional, Rosoli, Analia, additional, Valdez, Daniel, additional, Caetano, Sheila C., additional, Rattazzi, Alexia, additional, and Paula, Cristiane S., additional

Published
2022
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12. Profile of Service Use and Barriers to Access among Brazilian Children and Adolescents with Autism Spectrum Disorders

Author

Araripe, Beatriz Lobo, primary, Montiel-Nava, Cecilia, additional, Bordini, Daniela, additional, Cunha, Graccielle R., additional, Garrido, Gabriela, additional, Cukier, Sebastián, additional, Garcia, Ricardo, additional, Rosoli, Analia, additional, Valdez, Daniel, additional, Caetano, Sheila C., additional, Rattazzi, Alexia, additional, and Paula, Cristiane Silvestre, additional

Published
2022
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15. Shorter leukocyte telomere length in patients at ultra high risk for psychosis

Author

Maurya, Pawan Kumar, Rizzo, Lucas Bortolotto, Xavier, Gabriela, Tempaku, Priscila Farias, Zeni-Graiff, Maiara, Santoro, Marcos L., Mazzotti, Diego Robles, Zugman, André, Pan, Pedro, Noto, Cristiano, Maes, Michael, Asevedo, Elson, Mansur, Rodrigo B., Cunha, Graccielle R., Gadelha, Ary, Bressan, Rodrigo A., Belangero, Sintia Iole, and Brietzke, Elisa

Published
2017
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16. Peripheral levels of superoxide dismutase and glutathione peroxidase in youths in ultra-high risk for psychosis: a pilot study

Author

Zeni-Graiff, Maiara, primary, Rios, Adiel C., additional, Maurya, Pawan K., additional, Rizzo, Lucas B., additional, Sethi, Sumit, additional, Yamagata, Ana S., additional, Mansur, Rodrigo B., additional, Pan, Pedro M., additional, Asevedo, Elson, additional, Cunha, Graccielle R., additional, Zugman, André, additional, Bressan, Rodrigo A., additional, Gadelha, Ary, additional, and Brietzke, Elisa, additional

Published
2017
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17. Brain-derived neurotrophic factor, impaired glucose metabolism, and bipolar disorder course

Author

Mansur, Rodrigo B, Santos, Camila M, Rizzo, Lucas B, Asevedo, Elson, Cunha, Graccielle R, Noto, Mariane N, Pedrini, Mariana, Zeni-Graiff, Maiara, Cordeiro, Quirino, Vinberg, Maj, Kapczinski, Flavio, McIntyre, Roger S, Brietzke, Elisa, Mansur, Rodrigo B, Santos, Camila M, Rizzo, Lucas B, Asevedo, Elson, Cunha, Graccielle R, Noto, Mariane N, Pedrini, Mariana, Zeni-Graiff, Maiara, Cordeiro, Quirino, Vinberg, Maj, Kapczinski, Flavio, McIntyre, Roger S, and Brietzke, Elisa

Abstract

OBJECTIVES: The neurotrophin brain-derived neurotrophic factor (BDNF) has been proposed as a potential biomarker in bipolar disorder (BD). However, current evidence is limited and results have been highly heterogeneous. This study aimed to assess the moderating effect of impaired glucose metabolism (IGM) on plasma levels of BDNF in individuals with BD, and on the relationship between BDNF and variables of illness course.METHODS: We measured and compared the plasma levels of BDNF in individuals with BD (n=57) and healthy controls (n=26). IGM was operationalized as pre-diabetes or type 2 diabetes mellitus. Information related to current and past psychiatric/medical history, as well as prescription of pharmacological treatments was also captured.RESULTS: Individuals with BD had lower levels of BDNF, relative to healthy controls, after adjustment for age, gender, current medications, smoking, alcohol use, and IGM (P=.046). There was no effect of IGM (P=.860) and no interaction between BD diagnosis and IGM (P=.893). Peripheral BDNF levels were positively correlated with lifetime depressive episodes (P<.001), psychiatric hospitalizations (P=.001) and suicide attempts (P=.021). IGM moderated the association between BDNF and the number of previous mood episodes (P<.001), wherein there was a positive correlation in euglycemic participants and a negative correlation in individuals with IGM.CONCLUSIONS: BD is independently associated with lower levels of BDNF; IGM may modify the relationship between BDNF and BD course, suggesting an interactive effect of BDNF with metabolic status on illness progression.

Published
2016

18. Perinatal complications, lipid peroxidation, and mental health problems in a large community pediatric sample

Author

Mansur, Rodrigo B., primary, Cunha, Graccielle R., additional, Asevedo, Elson, additional, Zugman, André, additional, Rios, Adiel C., additional, Salum, Giovanni A., additional, Pan, Pedro M., additional, Gadelha, Ary, additional, Levandowski, Mateus L., additional, Belangero, Síntia I., additional, Manfro, Gisele G., additional, Stertz, Laura, additional, Kauer-Sant’anna, Márcia, additional, Miguel, Eurípedes C., additional, Bressan, Rodrigo A., additional, Mari, Jair J., additional, Grassi-Oliveira, Rodrigo, additional, and Brietzke, Elisa, additional

Published
2016
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19. Socioeconomic Disadvantage Moderates the Association between Peripheral Biomarkers and Childhood Psychopathology

Author

Mansur, Rodrigo B., primary, Cunha, Graccielle R., additional, Asevedo, Elson, additional, Zugman, André, additional, Zeni-Graiff, Maiara, additional, Rios, Adiel C., additional, Sethi, Sumit, additional, Maurya, Pawan K., additional, Levandowski, Mateus L., additional, Gadelha, Ary, additional, Pan, Pedro M., additional, Stertz, Laura, additional, Belangero, Síntia I., additional, Kauer-Sant' Anna, Márcia, additional, Teixeira, Antônio L., additional, Mari, Jair J., additional, Rohde, Luis A., additional, Miguel, Euripedes C., additional, McIntyre, Roger S., additional, Grassi-Oliveira, Rodrigo, additional, Bressan, Rodrigo A., additional, and Brietzke, Elisa, additional

Published
2016
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21. Brain-derived neurotrophic factor, impaired glucose metabolism, and bipolar disorder course

Author

Mansur, Rodrigo B, primary, Santos, Camila M, additional, Rizzo, Lucas B, additional, Asevedo, Elson, additional, Cunha, Graccielle R, additional, Noto, Mariane N, additional, Pedrini, Mariana, additional, Zeni-Graiff, Maiara, additional, Cordeiro, Quirino, additional, Vinberg, Maj, additional, Kapczinski, Flavio, additional, McIntyre, Roger S, additional, and Brietzke, Elisa, additional

Published
2016
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23. Peripheral levels of superoxide dismutase and glutathione peroxidase in youths in ultra-high risk for psychosis: a pilot study

Author

Zeni-Graiff, Maiara, Rios, Adiel C., Maurya, Pawan K., Rizzo, Lucas B., Sethi, Sumit, Yamagata, Ana S., Mansur, Rodrigo B., Pan, Pedro M., Asevedo, Elson, Cunha, Graccielle R., Zugman, André, Bressan, Rodrigo A., Gadelha, Ary, and Brietzke, Elisa

Abstract

IntroductionOxidative stress has been documented in chronic schizophrenia and in the first episode of psychosis, but there are very little data on oxidative stress prior to the disease onset.ObjectiveThis work aimed to compare serum levels of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in young individuals at ultra-high risk (UHR) of developing psychosis with a comparison healthy control group (HC).MethodsThirteen UHR subjects and 29 age- and sex-matched healthy controls (HC) were enrolled in this study. Clinical assessment included the Comprehensive Assessment of At-Risk Mental States (CAARMS), the Semi-Structured Clinical Interview for DSM-IV Axis-I (SCID-I) or the Kiddie-SADS-Present and Lifetime Version (K-SADS-PL), and the Global Assessment of Functioning (GAF) scale. Activities of SOD and GPx were measured in serum by the spectrophotometric method using enzyme-linked immunosorbent assay kits.ResultsAfter adjusting for age and years of education, there was a significant lower activity of SOD and lower GPX activity in the UHR group compared to the healthy control group (rate ratio [RR]=0.330, 95% CI 0.187; 0.584, p<0.001 and RR=0.509, 95% CI 0.323; 0.803, p=0.004, respectively). There were also positive correlations between GAF functioning scores and GPx and SOD activities.ConclusionOur results suggest that oxidative imbalances could be present prior to the onset of full-blown psychosis, including in at-risk stages. Future studies should replicate and expand these results.

Published
2019
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24. Gene expression analysis in blood of ultra-high risk subjects compared to first-episode of psychosis patients and controls

Author

Santoro, Marcos Leite, primary, Gadelha, Ary, additional, Ota, Vanessa K, additional, Cunha, Graccielle R, additional, Asevedo, Elson, additional, Noto, Cristiano S, additional, Spindola, Leticia M, additional, Pan, Pedro M, additional, Talarico, Fernanda, additional, Mansur, Rodrigo B, additional, Silva, Patricia N, additional, Brietzke, Elisa, additional, Cordeiro, Quirino, additional, Bressan, Rodrigo A, additional, and Belangero, Sintia Iole, additional

Published
2015
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25. Brain tumor in a patient with attenuated psychosis syndrome

Author

Zugman, Andre, primary, Pan, Pedro M., additional, Gadelha, Ary, additional, Mansur, Rodrigo B., additional, Asevedo, Elson, additional, Cunha, Graccielle R., additional, Silva, Paula F.R., additional, Brietzke, Elisa, additional, and Bressan, Rodrigo A., additional

Published
2013
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27. Identifying Depression Early in Adolescence: assessing the performance of a risk score for future onset of depression in an independent Brazilian sample.

Author

Cunha GR, Caye A, Pan P, Fisher HL, Pereira R, Ziebold C, Bressan R, Miguel EC, Salum GA, Rohde LA, Kohrt BA, Mondelli V, Kieling C, and Gadelha A

Subjects
Humans, Adolescent, Brazil epidemiology, Risk Factors, Longitudinal Studies, Depression diagnosis, Depression epidemiology
Abstract

Objective: The Identifying Depression Early in Adolescence Risk Score (IDEA-RS) was recently developed in Brazil using data from the Pelotas 1993 Birth Cohort to estimate the individualized probability of developing depression in adolescence. This model includes 11 sociodemographic variables and has been assessed in longitudinal studies from four other countries. We aimed to test the performance of IDEA-RS in an independent, community-based, school-attending sample within the same country: the Brazilian High-Risk Cohort., Methods: Standard external validation, refitted, and case mix-corrected models were used to predict depression among 1442 youth followed from a mean age of 13.5 years at baseline to 17.7 years at follow-up, using probabilities calculated with IDEA-RS coefficients., Results: The area under the curve was 0.65 for standard external validation, 0.70 for the case mix-corrected model, and 0.69 for the refitted model, with discrimination consistently above chance for predicting depression in the new dataset. There was some degree of miscalibration, corrected by model refitting (calibration-in-the-large reduced from 0.77 to 0)., Conclusion: IDEA-RS was able to parse individuals with higher or lower probability of developing depression beyond chance in an independent Brazilian sample. Further steps should include model improvements and additional studies in populations with high levels of subclinical symptoms to improve clinical decision making., Competing Interests: AC has acted as a consultant for Knight Therapeutics in the past year. VM has received research funding from Johnson & Johnson, a pharmaceutical company interested in the development of anti-inflammatory strategies for depression, but the research described in this paper is unrelated to this funding. LAR has received grant or research support from, served as a consultant to, and served on the speakers’ bureau of Abbott, Aché, Bial, Medice, Novartis/Sandoz, Pfizer/Upjohn, and Shire/ Takeda in the last three years; has received authorship royalties from Oxford Press and ArtMed; the ADHD and Juvenile Bipolar Disorder Outpatient Programs chaired by him has received unrestricted educational and research support from the following pharmaceutical companies in the last three years: Novartis/Sandoz and Shire/Takeda. The other authors report no conflicts of interest.

Published
2023
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28. Clozapine-induced esophagitis at therapeutic dose: a case report.

Author

Gonçalves B, Castro J, Zanini MA, Bittencourt L, Gadelha A, Cunha GR, Coelho FM, Tufik S, Bressan RA, and Brietzke E

Subjects
Antipsychotic Agents administration & dosage, Clozapine administration & dosage, Drug Therapy, Combination, Humans, Male, Middle Aged, Schizophrenia drug therapy, Antipsychotic Agents adverse effects, Clozapine adverse effects, Esophagitis chemically induced
Published
2016
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