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20 results on '"Cuneo, Ami"'

2. Postinjury Alcohol Use Is Associated With Prolonged Recovery After Concussion in NCAA Athletes

Author

Chang, Roger C., Singleton, Michael, Chrisman, Sara P. D., Giza, Christopher C., Cuneo, Ami Z., Murinova, Natalia, Broglio, Steven P., McCrea, Michael, McAllister, Thomas W., Sharma, Tara L., Hoy, April Marie (Reed), Hazzard, Joseph B., Jr, Kelly, Louise A., Ortega, Justus D., Port, Nicholas, Putukian, Margot, Langford, T. Dianne, Tierney, Ryan, McGinty, Gerald, OʼDonnell, Patrick, Cameron, Kenneth, Houston, Megan, Svoboda, Steven, Goldman, Joshua, Benjamin, Holly J., Buckley, Thomas, Kaminski, Thomas W., Clugston, James R., Schmidt, Julianne D., Feigenbaum, Luis A., Eckner, James T., Mihalik, Jason P., Miles, Jessica Dysart, Anderson, Scott, Master, Christina L., Kontos, Anthony P., Bazarian, Jeffrey J., Brooks, M. Alison, Duma, Stefan, Rowson, Steven, Miles, Christopher M., Dykhuizen, Brian H., and Lintner, Laura

Published
2023
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6. Retinal Axonal Loss Begins Early in the Course of Multiple Sclerosis and Is Similar between Progressive Phenotypes

Author

Gelfand, Jeffrey M, Goodin, Douglas S, Boscardin, W John, Nolan, Rachel, Cuneo, Ami, and Green, Ari J

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Prevention, Multiple Sclerosis, Autoimmune Disease, Neurodegenerative, Eye Disease and Disorders of Vision, Brain Disorders, Clinical Research, Neurosciences, Eye, Neurological, Adult, Axons, Cross-Sectional Studies, Disease Progression, Female, Humans, Male, Middle Aged, Optic Neuritis, Phenotype, Retina, Tomography, Optical Coherence, General Science & Technology
Abstract

BackgroundTo determine whether retinal axonal loss is detectable in patients with a clinically isolated syndrome (CIS), a first clinical demyelinating attack suggestive of multiple sclerosis (MS), and examine patterns of retinal axonal loss across MS disease subtypes.Methodology/principal findingsSpectral-domain Optical Coherence Tomography was performed in 541 patients with MS, including 45 with high-risk CIS, 403 with relapsing-remitting (RR)MS, 60 with secondary-progressive (SP)MS and 33 with primary-progressive (PP)MS, and 53 unaffected controls. Differences in retinal nerve fiber layer (RNFL) thickness and macular volume were analyzed using multiple linear regression and associations with age and disease duration were examined in a cross-sectional analysis. In eyes without a clinical history of optic neuritis (designated as "eyes without optic neuritis"), the total and temporal peripapillary RNFL was thinner in CIS patients compared to controls (temporal RNFL by -5.4 µm [95% CI -0.9 to--9.9 µm, p = 0.02] adjusting for age and sex). The total (p = 0.01) and temporal (p = 0.03) RNFL was also thinner in CIS patients with clinical disease for less than 1 year compared to controls. In eyes without optic neuritis, total and temporal RNFL thickness was nearly identical between primary and secondary progressive MS, but total macular volume was slightly lower in the primary progressive group (pRRMS>CIS--with proportionally greater thinning in eyes previously affected by clinically evident optic neuritis. Retinal axonal loss begins early in the course of MS. In the absence of clinically evident optic neuritis, RNFL thinning is nearly identical between progressive MS subtypes.

Published
2012

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