Search

Your search keyword '"Cummins, Max L."' showing total 20 results
Start Over Author "Cummins, Max L."
20 results on '"Cummins, Max L."'

3. Genomic analysis of Citrobacter from Australian wastewater and silver gulls reveals novel sequence types carrying critically important antibiotic resistance genes

Author

Hem, Sopheak, Cummins, Max L., Wyrsch, Ethan R., Drigo, Barbara, Hoye, Bethany J., Maute, Kimberly, Sanderson-Smith, Martina, Gorman, Jody, Bogema, Daniel R., Jenkins, Cheryl, Deutscher, Ania T., Yam, Jerald, Hai, Faisal, Donner, Erica, Jarocki, Veronica M., and Djordjevic, Steven P.

Published
2024
Full Text
View/download PDF

4. A role for ColV plasmids in the evolution of pathogenic Escherichia coli ST58

Author

Reid, Cameron J., Cummins, Max L., Börjesson, Stefan, Brouwer, Michael S. M., Hasman, Henrik, Hammerum, Anette M., Roer, Louise, Hess, Stefanie, Berendonk, Thomas, Nešporová, Kristina, Haenni, Marisa, Madec, Jean-Yves, Bethe, Astrid, Michael, Geovana B., Schink, Anne-Kathrin, Schwarz, Stefan, Dolejska, Monika, and Djordjevic, Steven P.

Published
2022
Full Text
View/download PDF

11. A role for ColV plasmids in the evolution of pathogenic Escherichia coli ST58

Author

Reid, Cameron J, Cummins, Max L, Börjesson, Stefan, Brouwer, Michael S M, Hasman, Henrik, Hammerum, Anette M, Roer, Louise, Hess, Stefanie, Berendonk, Thomas, Nešporová, Kristina, Haenni, Marisa, Madec, Jean-Yves, Bethe, Astrid, Michael, Geovana B, Schink, Anne-Kathrin, Schwarz, Stefan, Dolejska, Monika, Djordjevic, Steven P, Reid, Cameron J, Cummins, Max L, Börjesson, Stefan, Brouwer, Michael S M, Hasman, Henrik, Hammerum, Anette M, Roer, Louise, Hess, Stefanie, Berendonk, Thomas, Nešporová, Kristina, Haenni, Marisa, Madec, Jean-Yves, Bethe, Astrid, Michael, Geovana B, Schink, Anne-Kathrin, Schwarz, Stefan, Dolejska, Monika, and Djordjevic, Steven P

Abstract

Escherichia coli ST58 has recently emerged as a globally disseminated uropathogen that often progresses to sepsis. Unlike most pandemic extra-intestinal pathogenic E. coli (ExPEC), which belong to pathogenic phylogroup B2, ST58 belongs to the environmental/commensal phylogroup B1. Here, we present a pan-genomic analysis of a global collection of 752 ST58 isolates from diverse sources. We identify a large ST58 sub-lineage characterized by near ubiquitous carriage of ColV plasmids, which carry genes encoding virulence factors, and by a distinct accessory genome including genes typical of the Yersiniabactin High Pathogenicity Island. This sub-lineage includes three-quarters of all ExPEC sequences in our study and has a broad host range, although poultry and porcine sources predominate. By contrast, strains isolated from cattle often lack ColV plasmids. Our data indicate that ColV plasmid acquisition contributed to the divergence of the major ST58 sub-lineage, and different sub-lineages inhabit poultry, swine and cattle., This study was partially funded by Czech Science Foundation Grant no. 18-23532S awarded to M.D. It was also supported by an Australian Government Medical Research Future Fund project (MRFF75873), the Australian Centre for Genomic Epidemiological Microbiology (AusGEM), a strategic research initiative between the New South Wales Department of Primary Industries and the University of Technology Sydney and Australian Research Council Linkage Project LP150100912.

Published
2022
Full Text
View/download PDF

12. Genomic surveillance for antimicrobial resistance — a One Health perspective

Author

Djordjevic, Steven P., Jarocki, Veronica M., Seemann, Torsten, Cummins, Max L., Watt, Anne E., Drigo, Barbara, Wyrsch, Ethan R., Reid, Cameron J., Donner, Erica, and Howden, Benjamin P.

Abstract

Antimicrobial resistance (AMR) — the ability of microorganisms to adapt and survive under diverse chemical selection pressures — is influenced by complex interactions between humans, companion and food-producing animals, wildlife, insects and the environment. To understand and manage the threat posed to health (human, animal, plant and environmental) and security (food and water security and biosecurity), a multifaceted ‘One Health’ approach to AMR surveillance is required. Genomic technologies have enabled monitoring of the mobilization, persistence and abundance of AMR genes and mutations within and between microbial populations. Their adoption has also allowed source-tracing of AMR pathogens and modelling of AMR evolution and transmission. Here, we highlight recent advances in genomic AMR surveillance and the relative strengths of different technologies for AMR surveillance and research. We showcase recent insights derived from One Health genomic surveillance and consider the challenges to broader adoption both in developed and in lower- and middle-income countries.

Published
2023
Full Text
View/download PDF

13. Whole-Genome Sequence Analysis of an Extensively Drug-Resistant Salmonella enterica Serovar Agona Isolate from an Australian Silver Gull ( Chroicocephalus novaehollandiae ) Reveals the Acquisition of Multidrug Resistance Plasmids

Author

Cummins, Max L., primary, Sanderson-Smith, Martina, additional, Newton, Peter, additional, Carlile, Nicholas, additional, Phalen, David N., additional, Maute, Kimberly, additional, Monahan, Leigh G., additional, Hoye, Bethany J., additional, and Djordjevic, Steven P., additional

Published
2020
Full Text
View/download PDF

18. Genetic Features of mcr-1 Mediated Colistin Resistance in CMY-2-Producing Escherichia coli From Romanian Poultry

Author

Maciuca, Iuliana E., primary, Cummins, Max L., additional, Cozma, Andreea P., additional, Rimbu, Cristina M., additional, Guguianu, Eleonora, additional, Panzaru, Carmen, additional, Licker, Monica, additional, Szekely, Edit, additional, Flonta, Mirela, additional, Djordjevic, Steven P., additional, and Timofte, Dorina, additional

Published
2019
Full Text
View/download PDF

19. Whole genome sequence analysis of Australian avian pathogenic Escherichia coli that carry the class 1 integrase gene

Author

Cummins, Max L., primary, Reid, Cameron J., additional, Roy Chowdhury, Piklu, additional, Bushell, Rhys N., additional, Esbert, Nicolas, additional, Tivendale, Kelly A., additional, Noormohammadi, Amir H., additional, Islam, Shaiful, additional, Marenda, Marc S., additional, Browning, Glenn F., additional, Markham, Philip F., additional, and Djordjevic, Steven P., additional

Published
2019
Full Text
View/download PDF

20. Implementing a national programme of pathogen genomics for public health: the Australian Pathogen Genomics Program (AusPathoGen).

Author

Webb JR, Andersson P, Sim E, Zahedi A, Donald A, Hoang T, Watt AE, Agius JE, Donato CM, Cummins ML, Zulfiqar T, Nghiem S, Lin C, Menouhos D, Leong LEX, Baird R, Kennedy K, Cooley L, Speers D, Lim CK, de Ligt J, Ferdinand A, Glass K, Kirk MD, Djordjevic SP, Sloggett C, Horan K, Seemann T, Sintchenko V, Jennison AV, and Howden BP

Abstract

Delivering large-scale routine pathogen genomics surveillance for public health is of considerable interest, although translational research models that promote national-level implementation are not well defined. We describe the development and deployment of the Australian Pathogen Genomics Program (AusPathoGen), a comprehensive national partnership between academia, public health laboratories, and public health agencies that commenced in January, 2021. Successfully establishing and delivering a national programme requires inclusive and transparent collaboration between stakeholders, defined and clear focus on public health priorities, and support for strengthening national genomics capacity. Major enablers for delivering such a programme include technical solutions for data integration and analysis, such as the genomics surveillance platform AusTrakka, standard bioinformatic analysis methods, and national ethics and data sharing agreements that promote nationally integrated surveillance systems. Training of public health officials to interpret and act on genomic data is crucial, and evaluation and cost-effectiveness programmes will provide a benchmark and evidence for sustainable investment in genomics nationally and globally., Competing Interests: Declaration of interests We declare no competing interests., (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results