546 results on '"Cummings, J. R"'
Search Results
2. Healthcare Professional (HCP) and Patient Usability Evaluation and Preferences of Two Auto-injector Devices for Self-Injection of Biosimilars, SB4 and SB5: A Literature Review
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Corominas, Héctor, Young, David, Cummings, J. R. Fraser, Bouhnik, Yoram, Armuzzi, Alessandro, Thaci, Diamant, and Kim, Jihyun
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- 2023
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3. Clinical impact of syndromic molecular point-of-care testing for gastrointestinal pathogens in adults hospitalised with suspected gastroenteritis (GastroPOC): a pragmatic, open-label, randomised controlled trial
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Brendish, Nathan J, Beard, Kate R, Malachira, Ahalya K, Tanner, Alex R, Sanga-Nyirongo, Langizya, Gwiggner, Markus, Cummings, J R Fraser, Moyses, Helen E, and Clark, Tristan W
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- 2023
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4. Iron deficiency and fatigue in inflammatory bowel disease: A systematic review.
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Sartain, Stephanie, Al-Ezairej, Maryam, McDonnell, Martin, Westoby, Catherine, Katarachia, Vasiliki, Wootton, Stephen A., and Cummings, J. R. Fraser
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Background: It is unclear what impact iron deficiency has on fatigue in people with inflammatory bowel disease (IBD). This systematic review examined the evidence of whether iron deficiency, with or without anaemia, was associated with fatigue in IBD. Fatigue is a common symptom in patients with IBD that can be difficult to manage and treat. A greater understanding of the role and contribution of iron deficiency to fatigue may help improve the management of this condition. Methods: The databases searched were MEDLINE, OVID, CINAHL and Web of Science. Inclusion criteria were studies measuring iron status for iron deficiency (ID) and patient-reported outcome measures (PROMs) for fatigue in patients with IBD of any level of disease activity. Assessment of bias was conducted using the Newcastle Ottawa Scale. Studies were grouped for syntheses according to whether exposure was iron deficiency without anaemia (IDWA) or ID regardless of haemoglobin level. Results: Two hundred and eighty-five individual database results were identified and screened; 32 complete records were reviewed, from which seven studies with 1425 individuals were deemed eligible for inclusion in the results synthesis. Considerable variation in the methods and statistical analysis used to investigate the relationship between ID and fatigue prevented any quantitative synthesis. Studies varied by population disease activity levels, approaches used to define ID and PROMs used to measure fatigue. Three studies directly compared fatigue scores in IDWA to those not iron deficient, two of which showed patients with IDWA had significantly lower fatigue scores. Four studies used ID irrespective of anaemia as the exposure and reported mixed results on fatigue, with only one study reporting a higher prevalence of fatigue in the ID group. Conclusions: There was marked heterogeneity between studies in this review. Two studies found evidence of a slight increase in fatigue levels in patients with IDWA. Though this does not explain all fatigue in patients with IBD, iron replacement should be considered to improve fatigue in iron-deficient patients. [ABSTRACT FROM AUTHOR]
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- 2025
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5. Simultaneous optical/gamma-ray observations of GRB 121217's prompt emission
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Elliott, J., Yu, H. -F., Schmidl, S., Greiner, J., Gruber, D., Oates, S., Kobayashi, S., Zhang, B., Cummings, J. R., Filgas, R., Gehrels, N., Grupe, D., Kann, D. A., Klose, S., Krühler, T., Guelbenzu, A. Nicuesa, Rau, A., Rossi, A., Siegel, M., Schady, P., Sudilovsky, V., Tanga, M., and Varela, K.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Since the advent of the Swift satellite it has been possible to obtain precise localisations of GRB positions of sub-arcsec accuracy within seconds, facilitating ground-based robotic telescopes to automatically slew to the target within seconds. This has yielded a plethora of observational data for the afterglow phase of the GRB, but the quantity of data (<2 keV) covering the initial prompt emission still remains small. Only in a handful of cases has it been possible obtain simultaneous coverage of the prompt emission in a multi-wavelength regime (gamma-ray to optical), as a result of: observing the field by chance prior to the GRB (e.g. 080319B/naked-eye burst), long-prompt emission (e.g., 080928, 110205A) or triggered on a pre-cursor (e.g., 041219A, 050820A, 061121). This small selection of bursts have shown both correlated and uncorrelated gamma-ray and optical light curve behaviour, and the multi-wavelength emission mechanism remains far from resolved (i.e. single population synchrotron self-Component, electron distributions, additional neutron components or residual collisions). Such multi-wavelength observations during the GRB prompt phase are pivotal in providing further insight on the poorly understood prompt emission mechanism. We add to this small sample the Swift burst 121217A that had two distinct periods of prompt emission separated by ~700 s, observed by Swift/BAT, Swift/XRT and Fermi/GBM. As a result of the time delay of the second emission, it enabled optical imaging (from 3 to 7 bands) to be taken with the GROND instrument to a resolution as fine as 10s. This multi-wavelength data will hopefully allow us to shed more light on the current picture of prompt emission physics., Comment: 9 pages, 5 figures, 7th Huntsville Gamma-Ray Burst Symposium, GRB 2013: paper 32 in eConf Proceedings C1304143
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- 2013
6. Prompt emission of GRB 121217A from gamma-rays to the NIR
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Elliott, J., Yu, H. -F., Schmidl, S., Greiner, J., Gruber, D., Oates, S., Kobayashi, S., Zhang, B., Cummings, J. R., Filgas, R., Gehrels, N., Grupe, D., Kann, D. A., Klose, S., Krühler, T., Guelbenzu, A. Nicuesa, Rau, A., Rossi, A., Siegel, M., Schady, P., Sudilovsky, V., Tanga, M., and Varela, K.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
The mechanism that causes the prompt-emission episode of gamma-ray bursts (GRBs) is still widely debated despite there being thousands of prompt detections. The favoured internal shock model relates this emission to synchrotron radiation. However, it does not always explain the spectral indices of the shape of the spectrum, often fit with empirical functions. Multi-wavelength observations are therefore required to help investigate the possible underlying mechanisms that causes the prompt emission. We present GRB 121217A, for which we were able to observe its near-infrared (NIR) emission during a secondary prompt-emission episode with the Gamma-Ray Burst Optical Near-infrared Detector (GROND) in combination with the Swift and Fermi satellites, covering an energy range of 0.001 keV to 100 keV. We determine a photometric redshift of z=3.1+/-0.1 with a line-of-sight extinction of A_V~0 mag, utilising the optical/NIR SED. From the afterglow, we determine a bulk Lorentz factor of Gamma~250 and an emission radius of R<10^18 cm. The prompt-emission broadband spectral energy distribution is well fit with a broken power law with b1=-0.3+/-0.1, b2=0.6+/-0.1 that has a break at E=6.6+/-0.9 keV, which can be interpreted as the maximum injection frequency. Self-absorption by the electron population below energies of E_a<6 keV suggest a magnetic field strength of B~10^5 G. However, all the best fit models underpredict the flux observed in the NIR wavelengths, which also only rebrightens by a factor of ~2 during the second prompt emission episode, in stark contrast to the X-ray emission, which rebrightens by a factor of ~100, suggesting an afterglow component is dominating the emission. We present GRB 121217A one of the few GRBs for which there are multi-wavelength observations of the prompt-emission period and show that it can be understood with a synchrotron radiation model., Comment: 13 pages, 8 figures, 6 tables, accepted for publication in Astronomy & Astrophysics
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- 2013
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7. GRB 130427A: a Nearby Ordinary Monster
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Maselli, A., Melandri, A., Nava, L., Mundell, C. G., Kawai, N., Campana, S., Covino, S., Cummings, J. R., Cusumano, G., Evans, P. A., Ghirlanda, G., Ghisellini, G., Guidorzi, C., Kobayashi, S., Kuin, P., La Parola, V., Mangano, V., Oates, S., Sakamoto, T., Serino, M., Virgili, F., Zhang, B. -B., Barthelmy, S., Beardmore, A., Bernardini, M. G., Bersier, D., Burrows, D., Calderone, G., Capalbi, M., Chiang, J., D'Avanzo, P., D'Elia, V., De Pasquale, M., Fugazza, D., Gehrels, N., Gomboc, A., Harrison, R., Hanayama, H., Japelj, J., Kennea, J., Kopac, D., Kouveliotou, C., Kuroda, D., Levan, A., Malesani, D., Marshall, F., Nousek, J., O'Brien, P., Osborne, J. P., Pagani, C., Page, K. L., Page, M., Perri, M., Pritchard, T., Romano, P., Saito, Y., Sbarufatti, B., Salvaterra, R., Steele, I., Tanvir, N., Vianello, G., Wiegand, B., Wiersema, K., Yatsu, Y., Yoshii, T., and Tagliaferri, G.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Long-duration Gamma-Ray Bursts (GRBs) are an extremely rare outcome of the collapse of massive stars, and are typically found in the distant Universe. Because of its intrinsic luminosity ($L\sim 3 \times 10^{53}$ erg s$^{-1}$) and its relative proximity ($z=0.34$), GRB 130427A was a unique event that reached the highest fluence observed in the gamma-ray band. Here we present a comprehensive multiwavelength view of GRB 130427A with Swift, the 2-m Liverpool and Faulkes telescopes and by other ground-based facilities, highlighting the evolution of the burst emission from the prompt to the afterglow phase. The properties of GRB 130427A are similar to those of the most luminous, high-redshift GRBs, suggesting that a common central engine is responsible for producing GRBs in both the contemporary and the early Universe and over the full range of GRB isotropic energies., Comment: 64 pages, 11 figures; published in Science. Update for a few references and correction of a typo in the name of one of the authors
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- 2013
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8. Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study
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Patel, Vinod, Mazhar, Zia, Saich, Rebecca, Colleypriest, Ben, Tham, Tony C, Iqbal, Tariq H, Kaushik, Vishal, Murugesan, Senthil, Singh, Salil, Weaver, Sean, Preston, Cathryn, Butt, Assad, Smith, Melissa, Basude, Dharamveer, Beale, Amanda, Langlands, Sarah, Direkze, Natalie, Parkes, Miles, Torrente, Franco, De La Revella Negro, Juan, MacDonald, Chris Ewen, Evans, Stephen M, Gunasekera, Anton V J, Thakur, Alka, Elphick, David, Shenoy, Achuth, Nwokolo, Chuka U, Dhar, Anjan, Cole, Andrew T, Agrawal, Anurag, Bridger, Stephen, Doherty, Julie, Cooper, Sheldon C, de Silva, Shanika, Mowat, Craig, Mayhead, Phillip, Lees, Charlie, Jones, Gareth, Ahmad, Tariq, Hart, James W, Gaya, Daniel R, Russell, Richard K, Gervais, Lisa, Dunckley, Paul, Mahmood, Tariq, Banim, Paul J R, Sonwalkar, Sunil, Ghosh, Deb, Phillips, Rosemary H, Azaz, Amer, Sebastian, Shaji, Shenderey, Richard, Armstrong, Lawrence, Bell, Claire, Hariraj, Radhakrishnan, Matthews, Helen, Jafferbhoy, Hasnain, Selinger, Christian P, Zamvar, Veena, De Caestecker, John S, Willmott, Anne, Miller, Richard, Babu, Palani Sathish, Tzivinikos, Christos, Bloom, Stuart L, Chung-Faye, Guy, Croft, Nicholas M, Fell, John ME, Harbord, Marcus, Hart, Ailsa, Hope, Ben, Irving, Peter M, Lindsay, James O, Mawdsley, Joel E, McNair, Alistair, Monahan, Kevin J, Murray, Charles D, Orchard, Timothy, Paul, Thankam, Pollok, Richard, Shah, Neil, Bouri, Sonia, Johnson, Matt W, Modi, Anita, Kabiru, Kasamu Dawa, Baburajan, B K, Bhaduri, Bim, Fagbemi, Andrew Adebayo, Levison, Scott, Limdi, Jimmy K, Watts, Gill, Foley, Stephen, Ramadas, Arvind, MacFaul, George, Mansfield, John, Grellier, Leonie, Morris, Mary-Anne, Tremelling, Mark, Hawkey, Chris, Kirkham, Sian, Charlton, Charles PJ, Rodrigues, Astor, Simmons, Alison, Lewis, Stephen J, Snook, Jonathon, Tighe, Mark, Goggin, Patrick M, De Silva, Aminda N, Lal, Simon, Smith, Mark S, Panter, Simon, Cummings, J R Fraser, Dharmisari, Suranga, Carter, Martyn, Watts, David, Mahmood, Zahid, McLain, Bruce, Sen, Sandip, Pigott, Anna J, Hobday, David, Wesley, Emma, Johnston, Richard, Edwards, Cathryn, Beckly, John, Vani, Deven, Ramakrishnan, Subramaniam, Chaudhary, Rakesh, Trudgill, Nigel J, Cooney, Rachel, Bell, Andy, Prasad, Neeraj, Gordon, John N, Brookes, Matthew J, Li, Andy, Gore, Stephen, Kennedy, Nicholas A, Heap, Graham A, Green, Harry D, Hamilton, Benjamin, Bewshea, Claire, Walker, Gareth J, Thomas, Amanda, Nice, Rachel, Perry, Mandy H, Chanchlani, Neil, Heerasing, Neel M, Hendy, Peter, Lin, Simeng, Lees, Charlie W, Hart, Ailsa L, Mansfield, John C, Lindsay, James, McDonald, Timothy J, McGovern, Dermot, and Goodhand, James R
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- 2019
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9. Discovery of the Onset of Rapid Accretion by a Dormant Massive Black Hole
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Burrows, D. N., Kennea, J. A., Ghisellini, G., Mangano, V., Zhang, B., Page, K. L., Eracleous, M., Romano, P., Sakamoto, T., Falcone, A. D., Osborne, J. P., Campana, S., Beardmore, A. P., Breeveld, A. A., Chester, M. M., Corbet, R., Covino, S., Cummings, J. R., D'Avanzo, P., D'Elia, V., Esposito, P., Evans, P. A., Fugazza, D., Gelbord, J. M., Hiroi, K., Holland, S. T., Huang, K. Y., Im, M., Israel, G., Jeon, Y., Jeon, Y. -B., Kawai, N., Krimm, H. A., Mészáros, P., Negoro, H., Omodei, N., Park, W. -K., Perkins, J. S., Sugizaki, M., Sung, H. -I., Tagliaferri, G., Troja, E., Ueda, Y., Urata, Y., Usui, R., Antonelli, L. A., Barthelmy, S. D., Cusumano, G., Giommi, P., Marshall, F. E., Melandri, A., Perri, M., Racusin, J. L., Sbarufatti, B., Siegel, M. H., and Gehrels, N.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Massive black holes are believed to reside at the centres of most galaxies. They can be- come detectable by accretion of matter, either continuously from a large gas reservoir or impulsively from the tidal disruption of a passing star, and conversion of the gravitational energy of the infalling matter to light. Continuous accretion drives Active Galactic Nuclei (AGN), which are known to be variable but have never been observed to turn on or off. Tidal disruption of stars by dormant massive black holes has been inferred indirectly but the on- set of a tidal disruption event has never been observed. Here we report the first discovery of the onset of a relativistic accretion-powered jet in the new extragalactic transient, Swift J164449.3+573451. The behaviour of this new source differs from both theoretical models of tidal disruption events and observations of the jet-dominated AGN known as blazars. These differences may stem from transient effects associated with the onset of a powerful jet. Such an event in the massive black hole at the centre of our Milky Way galaxy could strongly ionize the upper atmosphere of the Earth, if beamed towards us., Comment: Submitted to Nature. 4 pages, 3 figures (main paper). 26 pages, 13 figures (supplementary information)
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- 2011
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10. The Second Swift BAT Gamma-Ray Burst Catalog
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Sakamoto, T., Barthelmy, S. D., Baumgartner, W. H., Cummings, J. R., Fenimore, E. E., Gehrels, N., Krimm, H. A., Markwardt, C. B., Palmer, D. M., Parsons, A. M., Sato, G., Stamatikos, M., Tueller, J., Ukwatta, T. N., and Zhang, B.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present the second Swift Burst Alert Telescope (BAT) catalog of gamma-ray bursts (GRBs), which contains 476 bursts detected by the BAT between 2004 December 19 and 2009 December 21. This catalog (hereafter the BAT2 catalog) presents burst trigger time, location, 90% error radius, duration, fluence, peak flux, time-averaged spectral parameters and time-resolved spectral parameters measured by the BAT. In the correlation study of various observed parameters extracted from the BAT prompt emission data, we distinguish among long-duration GRBs (L-GRBs), short-duration GRBs (S-GRBs), and short-duration GRBs with extended emission (S-GRBs with E.E.) to investigate differences in the prompt emission properties. The fraction of L-GRBs, S-GRBs and S-GRBs with E.E. in the catalog are 89%, 8% and 2% respectively. We compare the BAT prompt emission properties with the BATSE, BeppoSAX and HETE-2 GRB samples. We also correlate the observed prompt emission properties with the redshifts for the GRBs with known redshift. The BAT T90 and T50 durations peak at 70 s and 30 s, respectively. We confirm that the spectra of the BAT S-GRBs are generally harder than those of the L-GRBs. The time-averaged spectra of the BAT S-GRBs with E.E. are similar to those of the L-GRBs. Whereas, the spectra of the initial short spikes of the S-GRBs with E.E. are similar to those of the S-GRBs. We show that the BAT GRB samples are significantly softer than the BATSE bright GRBs, and that the time-averaged Epeak of the BAT GRBs peaks at 80 keV which is significantly lower energy than those of the BATSE sample which peak at 320 keV. The time-averaged spectral properties of the BAT GRB sample are similar to those of the HETE-2 GRB samples. By time-resolved spectral analysis, we find that only 10% of the BAT observed photon indices are outside the allowed region of the synchrotron shock model., Comment: 65 pages, 33 figures, 13 tables, Accepted in ApJS, Nine machine-readable tables are available at http://swift.gsfc.nasa.gov/docs/swift/results/bat2_catalog/
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- 2011
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11. Probing the Nature of Short Swift Bursts via Deep INTEGRAL Monitoring of GRB 050925
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Sakamoto, T., Barbier, L., Barthelmy, S. D., Cummings, J. R., Fenimore, E. E., Gehrels, N., Krimm, H. A., Markwardt, C. B., Palmer, D. M., Parsons, A. M., Sato, G., Stamatikos, M., and Tueller, J.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present results from Swift, XMM-Newton, and deep INTEGRAL monitoring in the region of GRB 050925. This short Swift burst is a candidate for a newly discovered soft gamma-ray repeater (SGR) with the following observational burst properties: 1) galactic plane (b=-0.1 deg) localization, 2) 150 msec duration, and 3) a blackbody rather than a simple power-law spectral shape (with a significance level of 97%). We found two possible X-ray counterparts of GRB 050925 by comparing the X-ray images from Swift XRT and XMM-Newton. Both X-ray sources show the transient behavior with a power-law decay index shallower than -1. We found no hard X-ray emission nor any additional burst from the location of GRB 050925 in ~5 Ms of INTEGRAL data. We discuss about the three BATSE short bursts which might be associated with GRB 050925, based on their location and the duration. Assuming GRB 050925 is associated with the H II regions (W 58) at the galactic longitude of l=70 deg, we also discuss the source frame properties of GRB 050925., Comment: 13 pages, 13 figures, accepted for publication in ASR special issue on Neutron Stars and Gamma Ray Bursts, full resolution of Fig 5 is available at http://asd.gsfc.nasa.gov/Takanori.Sakamoto/GRB050925/integral_ibis_images.eps
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- 2010
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12. Discovery of a new Soft Gamma Repeater: SGR J0418+5729
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van der Horst, A. J., Connaughton, V., Kouveliotou, C., Gogus, E., Kaneko, Y., Wachter, S., Briggs, M. S., Granot, J., Ramirez-Ruiz, E., Woods, P. M., Aptekar, R. L., Barthelmy, S. D., Cummings, J. R., Finger, M. H., Frederiks, D. D., Gehrels, N., Gelino, C. R., Gelino, D. M., Golenetskii, S., Hurley, K., Krimm, H. A., Mazets, E. P., McEnery, J. E., Meegan, C. A., Oleynik, P. P., Palmer, D. M., Pal'shin, V. D., Pe'er, A., Svinkin, D., Ulanov, M. V., van der Klis, M., von Kienlin, A., Watts, A. L., and Wilson-Hodge, C. A.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
On 2009 June 5, the Gamma-ray Burst Monitor (GBM) onboard the Fermi Gamma-ray Space Telescope triggered on two short, and relatively dim bursts with spectral properties similar to Soft Gamma Repeater (SGR) bursts. Independent localizations of the bursts by triangulation with the Konus-RF and with the Swift satellite, confirmed their origin from the same, previously unknown, source. The subsequent discovery of X-ray pulsations with the Rossi X-ray Timing Explorer (RXTE), confirmed the magnetar nature of the new source, SGR J0418+5729. We describe here the Fermi/GBM observations, the discovery and the localization of this new SGR, and our infrared and Chandra X-ray observations. We also present a detailed temporal and spectral study of the two GBM bursts. SGR J0418+5729 is the second source discovered in the same region of the sky in the last year, the other one being SGR J0501+4516. Both sources lie in the direction of the galactic anti-center and presumably at the nearby distance of ~2 kpc (assuming they reside in the Perseus arm of our galaxy). The near-threshold GBM detection of bursts from SGR J0418+5729 suggests that there may be more such dim SGRs throughout our galaxy, possibly exceeding the population of bright SGRs. Finally, using sample statistics, we conclude that the implications of the new SGR discovery on the number of observable active magnetars in our galaxy at any given time is <10, in agreement with our earlier estimates., Comment: 6 pages, 3 figures, 2 tables; accepted for publication in ApJL on 2010 January 8
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- 2009
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13. Cosmic-ray origin in OB associations and preferential acceleration of refractory elements: Evidence from abundances of elements 26Fe through 34Se
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Rauch, B. F., Link, J. T., Lodders, K., Israel, M. H., Barbier, L. M., Binns, W. R., Christian, E. R., Cummings, J. R., de Nolfo, G. A., Geier, S., Mewaldt, R. A., Mitchell, J. W., Schindler, S. M., Scott, L. M., Stone, E. C., Streitmatter, R. E., Waddington, C. J., and Wiedenbeck, M. E.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Astrophysics of Galaxies - Abstract
We report abundances of elements from 26Fe to 34Se in the cosmic radiation measured during fifty days of exposure of the Trans-Iron Galactic Element Recorder (TIGER) balloon-borne instrument. These observations add support to the concept that the bulk of cosmic-ray acceleration takes place in OB associations, and they further support cosmic-ray acceleration models in which elements present in interstellar grains are accelerated preferentially compared with those found in interstellar gas., Comment: 18 pages including 9 figures
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- 2009
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14. P245 Biologics Sequencing in Clinical Units (BISCUITS): Comparing outcomes in Crohn’s disease patients on second-line biologics
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Bartalucci, G, primary, Taylor, F, additional, Gleave, C, additional, Dobson, L, additional, Bodger, K, additional, Dodd, S, additional, Bloom, S, additional, Passey, A, additional, Nissinen, R, additional, Wirth, D, additional, Andreas, D, additional, Lee, J, additional, and Cummings, J R F, additional
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- 2024
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15. Real-World Experience of Adalimumab Biosimilar (ABP 501) Use in Patients with Inflammatory Bowel Disease in Europe
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Jin, Ran, primary, Nduka, Chidozie, additional, Courmier, Delphine, additional, Knight, Hannah, additional, Meadows, Rachael, additional, Piercy, James, additional, Cummings, J. R. F., additional, and Radziszewski, Waldemar, additional
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- 2023
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16. Micronutrient Status in Adult Crohn’s Disease during Clinical Remission: A Systematic Review
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McDonnell, Martin, primary, Sartain, Stephanie, additional, Westoby, Catherine, additional, Katarachia, Vasiliki, additional, Wootton, Stephen A., additional, and Cummings, J. R. Fraser, additional
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- 2023
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17. Epeak estimator for Gamma-Ray Bursts Observed by the Swift Burst Alert Telescope
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Sakamoto, T., Sato, G., Barbier, L., Barthelmy, S. D., Cummings, J. R., Fenimore, E. E., Gehrels, N., Hullinger, D., Krimm, H. A., Lamb, D. Q., Markwardt, C. B., Palmer, D. M., Parsons, A. M., Stamatikos, M., Tueller, J., and Ukwatta, T. N.
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Astrophysics - Abstract
We report a correlation based on a spectral simulation study of the prompt emission spectra of gamma-ray bursts (GRBs) detected by the Swift Burst Alert Telescope (BAT). The correlation is between the Epeak energy, which is the peak energy in the \nu F_\nu spectrum, and the photon index (\Gamma) derived from a simple power-law model. The Epeak - \Gamma relation, assuming the typical smoothly broken power-law spectrum of GRBs, is \log Epeak = 3.258 - 0.829\Gamma (1.3 < \Gamma < 2.3). We take into account not only a range of Epeak energies and fluences, but also distributions for both the low-energy photon index and the high-energy photon index in the smoothly broken power-law model. The distribution of burst durations in the BAT GRB sample is also included in the simulation. Our correlation is consistent with the index observed by BAT and Epeak measured by the BAT, and by other GRB instruments. Since about 85% of GRBs observed by the BAT are acceptably fit with the simple power-law model because of the relatively narrow energy range of the BAT, this relationship can be used to estimate Epeak when it is located within the BAT energy range., Comment: 27 pages, 31 figures, accepted for publication in ApJ
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- 2008
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18. An extremely luminous X-ray outburst at the birth of a supernova
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Soderberg, A. M., Berger, E., Page, K. L., Schady, P., Parrent, J., Pooley, D., Wang, X. -Y., Ofek, E. O., Cucchiara, A., Rau, A., Waxman, E., Simon, J. D., Bock, D. C. -J., Milne, P. A., Page, M. J., Barentine, J. C., Barthelmy, S. D., Beardmore, A. P., Bietenholz, M. F., Brown, P., Burrows, A., Burrows, D. N., Byrngelson, G., Cenko, S. B., Chandra, P., Cummings, J. R., Fox, D. B., Gal-Yam, A., Gehrels, N., Immler, S., Kasliwal, M., Kong, A. K. H., Krimm, H. A., Kulkarni, S. R., Maccarone, T. J., Meszaros, P., Nakar, E., O'Brien, P. T., Overzier, R. A., de Pasquale, M., Racusin, J., Rea, N., and York, D. G.
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Astrophysics - Abstract
Massive stars end their short lives in spectacular explosions, supernovae, that synthesize new elements and drive galaxy evolution. Throughout history supernovae were discovered chiefly through their delayed optical light, preventing observations in the first moments (hours to days) following the explosion. As a result, the progenitors of some supernovae and the events leading up to their violent demise remain intensely debated. Here we report the serendipitous discovery of a supernova at the time of explosion, marked by an extremely luminous X-ray outburst. We attribute the outburst to the break-out of the supernova shock-wave from the progenitor, and show that the inferred rate of such events agrees with that of all core-collapse supernovae. We forecast that future wide-field X-ray surveys will catch hundreds of supernovae each year in the act of explosion, and thereby enable crucial neutrino and gravitational wave detections that may ultimately unravel the explosion mechanism., Comment: Article to appear in the May 22 issue of Nature. Final version: 21 pages, 5 figures. High resolution figures and Supplementary Information available at http://www.astro.princeton.edu/~alicia/SN2008D/ Note: the results presented in this paper are under embargo by Nature until the publication date
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- 2008
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19. Global Properties of X-Ray Flashes and X-Ray-Rich Gamma-Ray Bursts Observed by Swift
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Sakamoto, T., Hullinger, D., Sato, G., Yamazaki, R., Barbier, L., Barthelmy, S. D., Cummings, J. R., Fenimore, E. E., Gehrels, N., Krimm, H. A., Lamb, D. Q., Markwardt, C. B., Osborne, J. P., Palmer, D. M., Parsons, A. M., Stamatikos, M., and Tueller, J.
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Astrophysics - Abstract
We describe and discuss the spectral and temporal characteristics of the prompt emission and X-ray afterglow emission of X-ray flashes (XRFs) and X-ray-rich gamma-ray bursts (XRRs) detected and observed by Swift between December 2004 and September 2006. We compare these characteristics to a sample of conventional classical gamma-ray bursts (C-GRBs) observed during the same period. We confirm the correlation between Epeak_obs and fluence noted by others and find further evidence that XRFs, XRRs and C-GRBs form a continuum. We also confirm that our known redshift sample is consistent with the correlation between the peak energy in the GRB rest frame (Epeak_src) and the isotropic radiated energy (Eiso), so called the Epeak_src-Eiso relation. The spectral properties of X-ray afterglows of XRFs and C-GRBs are similar, but the temporal properties of XRFs and C-GRBs are quite different. We found that the light curves of C-GRB afterglows show a break to steeper indices (shallow-to-steep break) at much earlier times than do XRF afterglows. Moreover, the overall luminosity of XRF X-ray afterglows is systematically smaller by a factor of two or more compared to that of C-GRBs. These distinct differences between the X-ray afterglows of XRFs and C-GRBs may be the key to understanding not only the mysterious shallow-to-steep break in X-ray afterglow light curves, but also the unique nature of XRFs., Comment: 50 pages, 22 figures, Accepted for publication in ApJ
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- 2008
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20. Discovery of the accretion-powered millisecond pulsar SWIFT J1756.9-2508 with a low-mass companion
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Krimm, H. A., Markwardt, C. B., Deloye, C. J., Romano, P., Chakrabarty, D., Campana, S., Cummings, J. R., Galloway, D. K., Gehrels, N., Hartman, J. M., Kaaret, P., Morgan, E. H., and Tueller, J.
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Astrophysics - Abstract
We report on the discovery by the Swift Gamma-Ray Burst Explorer of the eighth known transient accretion-powered millisecond pulsar, SWIFT J1756.9-2508, as part of routine observations with the Swift Burst Alert Telescope hard X-ray transient monitor. The pulsar was subsequently observed by both the X-Ray Telescope on Swift and the Rossi X-Ray Timing Explorer Proportional Counter Array. It has a spin frequency of 182 Hz (5.5 ms) and an orbital period of 54.7 minutes. The minimum companion mass is between 0.0067 and 0.0086 solar masses, depending on the mass of the neutron star, and the upper limit on the mass is 0.030 solar masses (95% confidence level). Such a low mass is inconsistent with brown dwarf models, and comparison with white dwarf models suggests that the companion is a He-dominated donor whose thermal cooling has been at least modestly slowed by irradiation from the accretion flux. No X-ray bursts, dips, eclipses or quasi-periodic oscillations were detected. The current outburst lasted approximately 13 days and no earlier outbursts were found in archival data., Comment: 13 pages, 2 figures, accepted by Astrophysical Journal Letters
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- 2007
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21. The First Swift BAT Gamma-Ray Burst Catalog
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Sakamoto, T., Barthelmy, S. D., Barbier, L., Cummings, J. R., Fenimore, E. E., Gehrels, N., Hullinger, D., Krimm, H. A., Markwardt, C. B., Palmer, D. M., Parsons, A. M., Sato, G., Stamatikos, M., Tueller, J., Ukwatta, T. N., and Zhang, B.
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Astrophysics - Abstract
We present the first Swift Burst Alert Telescope (BAT) catalog of gamma-ray bursts (GRBs), which contains bursts detected by the BAT between 2004 December 19 and 2007 June 16. This catalog (hereafter BAT1 catalog) contains burst trigger time, location, 90% error radius, duration, fluence, peak flux, and time averaged spectral parameters for each of 237 GRBs, as measured by the BAT. The BAT-determined position reported here is within 1.75' of the Swift X-ray Telescope (XRT)-determined position for 90% of these GRBs. The BAT T_90 and T_50 durations peak at 80 and 20 seconds, respectively. From the fluence-fluence correlation, we conclude that about 60% of the observed peak energies, Epeak, of BAT GRBs could be less than 100 keV. We confirm that GRB fluence to hardness and GRB peak flux to hardness are correlated for BAT bursts in analogous ways to previous missions' results. The correlation between the photon index in a simple power-law model and Epeak is also confirmed. We also report the current status for the on-orbit BAT calibrations based on observations of the Crab Nebula., Comment: 63 pages, 23 figures, Accepted in ApJS, Corrected for the BAT ground position, the image significance, and the error radius of GRB 051105, Five machine-readable tables are available at http://swift.gsfc.nasa.gov/docs/swift/results/bat1_catalog/
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- 2007
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22. The shock break-out of GRB 060218/SN 2006aj
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Campana, S., Mangano, V., Blustin, A. J., Brown, P., Burrows, D. N., Chincarini, G., Cummings, J. R., Cusumano, G., Della Valle, M., Malesani, D., Meszaros, P., Nousek, J. A., Page, M., Sakamoto, T., Waxman, E., Zhang, B., Dai, Z. G., Gehrels, N., Immler, S., Marshall, F. E., Mason, K. O., Moretti, A., O'Brien, P. T., Osborne, J. P., Page, K. L., Romano, P., Roming, P. W. A., Tagliaferri, G., Cominsky, L. R., Giommi, P., Godet, O., Kennea, J. A., Krimm, H., Angelini, L., Barthelmy, S. D., Boyd, P. T., Palmer, D. M., Wells, A. A., and White, N. E.
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Astrophysics - Abstract
Although the link between long Gamma Ray Bursts (GRBs) and supernovae (SNe) has been established, hitherto there have been no observations of the beginning of a supernova explosion and its intimate link to a GRB. In particular, we do not know however how a GRB jet emerges from the star surface nor how a GRB progenitor explodes. Here we report on observations of the close GRB060218 and its connection to SN2006aj. In addition to the classical non-thermal emission, GRB060218 shows a thermal component in its X-ray spectrum, which cools and shifts into the optical/UV band as time passes. We interpret these features as arising from the break out of a shock driven by a mildly relativistic shell into the dense wind surrounding the progenitor. Our observations allow us for the first time to catch a SN in the act of exploding, to directly observe the shock break-out and to provide strong evidence that the GRB progenitor was a Wolf-Rayet star., Comment: 12 pages, 3 color figures (final version). Accepted for publication in Nature
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- 2006
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23. Confirmation of the $\eps$ -- $\eiso$ (Amati) relation from the X-ray flash XRF 050416A observed by Swift/BAT
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Sakamoto, T., Barbier, L., Barthelmy, S. D., Cummings, J. R., Fenimore, E. E., Gehrels, N., Hullinger, D., Krimm, H. A., Markwardt, C. B., Palmer, D. M., Parsons, A. M., Sato, G., and Tueller, J.
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Astrophysics - Abstract
We report Swift Burst Alert Telescope (BAT) observations of the X-ray Flash (XRF) XRF 050416A. The fluence ratio between the 15-25 keV and 25-50 keV energy bands of this event is 1.5, thus making it the softest gamma-ray burst (GRB) observed by BAT so far. The spectrum is well fitted by the Band function with E^{\rm obs}_{\rm peak} of 15.0_{-2.7}^{+2.3} keV. Assuming the redshift of the host galaxy (z = 0.6535), the isotropic-equivalent radiated energy E_{\rm iso} and the peak energy at the GRB rest frame (E^{\rm src}_{\rm peak}) of XRF 050416A are not only consistent with the correlation found by Amati et al. and extended to XRFs by Sakamoto et al., but also fill-in the gap of this relation around the 30 - 80 keV range of E^{\rm src}_{\rm peak}. This result tightens the validity of the E^{\rm src}_{\rm peak} - E_{\rm iso} relation from XRFs to GRBs. We also find that the jet break time estimated using the empirical relation between E^{\rm src}_{\rm peak} and the collimation corrected energy E_{\gamma} is inconsistent with the afterglow observation by Swift X-ray Telescope. This could be due to the extra external shock emission overlaid around the jet break time or to the non existence of a jet break feature for XRF, which might be a further challenging for GRB jet emission, models and XRF/GRB unification scenarios., Comment: 16 pages, 4 figures; accepted for publication in ApJL
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- 2005
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24. An origin for short g-ray bursts unassociated with current star formation
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Barthelmy, S. D., Chincarini, G., Burrows, D. N., Gehrels, N., Covino, S., Moretti, A., Romano, P., O'Brien, P. T., Sarazin, C. L., Kouveliotou, C., Goad, M., Vaughan, S., Tagliaferri, G., Zhang, B., Antonelli, L. A., Campana, S., Cummings, J. R., D'Avanzo, P., Davies, M. B., Giommi, P., Grupe, D., Kaneko, Y., Kennea, J. A., King, A., Kobayashi, S., Melandri, A., Meszaros, P., Nousek, J. A., Patel, S., Sakamoto, T., and Wijers, R. A. M. J.
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Astrophysics - Abstract
Two short (<2 s) g-ray bursts (GRBs) have recently been localized and fading afterglow counterparts detected. The combination of these two results left unclear the nature of the host galaxies of the bursts, because one was a star-forming dwarf, while the other was probably an elliptical galaxy. Here we report the X-ray localization of a short burst (GRB 050724) with unusual g-ray and X-ray properties. The X-ray afterglow lies off the centre of an elliptical galaxy at a redshift of z=0.258, coincident with the position determined by ground-based optical and radio observations. The low level of star formation typical for elliptical galaxies makes it unlikely that the burst originated n a supernova explosion. A supernova origin was also ruled out for GRB 050709, even though that burst took place in a galaxy with current star formation. The isotropic energy for the short bursts is 2-3 orders of magnitude lower han that for the long bursts. Our results therefore suggest that an alternative source of bursts -- the of binary systems of neutron stars or a neutron star-black hole pair -- are the progenitors of short bursts., Comment: 11 pages of taxt plus figures (all in 1 file). Nature Letters (accepted; publish Dec 19, 2005)
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- 2005
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25. Swift observations of the X-ray bright GRB 050315
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Vaughan, S., Goad, M. R., Beardmore, A. P., O'Brien, P. T., Osborne, J. P., Page, K. L., Barthelmy, S. D., Burrows, D. N., Campana, S., Cannizzo, J. K., Capalbi, M., Chincarini, G., Cummings, J. R., Cusumano, G., Giommi, P., Godet, O., Hill, J. E., Kobayashi, S., Kumar, P., La Parola, V., Levan, A., Mangano, V., Meszaros, P., Moretti, A., Morris, D. C., Nousek, J. A., Pagani, C., Palmer, D. M., Racusin, J. L., Romano, P., Tagliaferri, G., Zhang, B., and Gehrels, N.
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Astrophysics - Abstract
This paper discusses Swift observations of the gamma-ray burst GRB 050315 (z=1.949) from 80 s to 10 days after the onset of the burst. The X-ray light curve displayed a steep early decay (t^-5) for ~200 s and several breaks. However, both the prompt hard X-ray/gamma-ray emission (observed by the BAT) and the first ~ 300 s of X-ray emission (observed by the XRT) can be explained by exponential decays, with similar decay constants. Extrapolating the BAT light curve into the XRT band suggests the rapidly decaying, early X-ray emission was simply a continuation of the fading prompt emission; this strong similarity between the prompt gamma-ray and early X-ray emission may be related to the simple temporal and spectral character of this X-ray rich GRB. The prompt (BAT) spectrum was a steep down to 15 keV, and appeared to continue through the XRT bandpass, implying a low peak energy, inconsistent with the Amati relation. Following the initial steep decline the X-ray afterglow did not fade for ~1.2*10^4 s, after which time it decayed with a temporal index of alpha ~ 0.7, followed by a second break at ~2.5*10^5 s to a slope of alpha ~ 2. The apparent `plateau' in the X-ray light curve, after the early rapid decay, makes this one of the most extreme examples of the steep-flat-steep X-ray light curves revealed by Swift. If the second afterglow break is identified with a jet break then the jet opening angle was theta_0 ~ 5 deg, and implying E_gamma > 10^50 erg., Comment: 10 pages, 10 figures. Accepted for publication in ApJ
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- 2005
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26. GRB050223: A faint Gamma-Ray Burst discovered by Swift
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Page, K. L., Rol, E., Levan, A. J., Zhang, B., Osborne, J. P., O'Brien, P. T., Beardmore, A. P., Burrows, D. N., Campana, S., Chincharini, G., Cummings, J. R., Cusumano, G., Gehrels, N., Giommi, P., Goad, M. R., Godet, O., Mangano, V., Tagliaferri, G., and Wells, A. A.
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Astrophysics - Abstract
GRB050223 was discovered by the Swift Gamma-Ray Burst Explorer on 23 February 2005 and was the first Gamma-Ray Burst to be observed by both Swift and XMM-Newton. At the time of writing (May 2005), it has one of the faintest GRB afterglows ever observed. The spacecraft could not slew immediately to the burst, so the first X-ray and optical observations occurred approximately 45 minutes after the trigger. Although no optical emission was found by any instrument, both Swift and XMM-Newton detected the fading X-ray afterglow. Combined data from both of these observatories show the afterglow to be fading monotonically as 0.99 +0.15/-0.12 over a time frame between 45 minutes to 27 hours post-burst. Spectral analysis, allowed largely by the higher through-put of XMM-Newton, implies a power-law with a slope of Gamma=1.75 +0.19/-0.18 and shows no evidence for absorption above the Galactic column of 7 x 10^20 cm^-2. From the X-ray decay and spectral slopes, a low electron power-law index of p = 1.3-1.9 is derived; the slopes also imply that a jet-break has not occured up to 27 hours after the burst. The faintness of GRB050223 may be due to a large jet opening or viewing angle or a high redshift., Comment: 6 pages, 5 figures. To be published in MNRAS Letters
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- 2005
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27. The Burst Alert Telescope (BAT) on the Swift MIDEX Mission
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Barthelmy, S. D., Barbier, L. M., Cummings, J. R., Fenimore, E. E., Gehrels, N., Hullinger, D., Krimm, H. A., Markwardt, C. B., Palmer, D. M., Parsons, A., Sato, G., Suzuki, M., Takahashi, T., Tashiro, M., and Tueller, J.
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Astrophysics - Abstract
The Burst Alert Telescope (BAT) is one of 3 instruments on the Swift MIDEX spacecraft to study gamma-ray bursts (GRBs). The BAT first detects the GRB and localizes the burst direction to an accuracy of 1-4 arcmin within 20 sec after the start of the event. The GRB trigger initiates an autonomous spacecraft slew to point the two narrow field-of-view (FOV) instruments at the burst location within 20-70 sec so to make follow-up x-ray and optical observations. The BAT is a wide-FOV, coded-aperture instrument with a CdZnTe detector plane. The detector plane is composed of 32,768 pieces of CdZnTe (4x4x2mm), and the coded-aperture mask is composed of approximately 52,000 pieces of lead (5x5x1mm) with a 1-m separation between mask and detector plane. The BAT operates over the 15-150 keV energy range with approximately 7 keV resolution, a sensitivity of approximately 10E-8 erg*cm^-2*s^-1, and a 1.4 sr (half-coded) FOV. We expect to detect >100 GRBs/yr for a 2-year mission. The BAT also performs an all-sky hard x-ray survey with a sensitivity of approximately 2 mCrab (systematic limit) and it serves as a hard x-ray transient monitor., Comment: 18 Pages, 12 Figures, To be published in Space Science Reviews
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- 2005
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28. A Link between Prompt Optical and Prompt Gamma-Ray Emission in Gamma-Ray Bursts
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Vestrand, W. T., Wozniak, P. R., Wren, J. A., Fenimore, E. E., Sakamoto, T., White, R. R., Casperson, D., Davis, H., Evans, S., Galassi, M., McGowan, K. E., Schier, J. A., Asa, J. W., Barthelmy, S. D., Cummings, J. R., Gehrels, N., Hullinger, D., Krimm, H. A., Markwardt, C. B., McLean, K., Palmer, D., Parsons, A., and Tueller, J.
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Astrophysics - Abstract
The prompt optical emission that arrives with gamma-rays from a cosmic gamma-ray burst (GRB) is a signature of the engine powering the burst, the properties of the ultra-relativistic ejecta of the explosion, and the ejecta's interactions with the surroundings. Until now, only GRB 990123 had been detected at optical wavelengths during the burst phase. Its prompt optical emission was variable and uncorrelated with the prompt gamma-ray emission, suggesting that the optical emission was generated by a reverse shock arising from the ejecta's collision with the surrounding material. Here we report prompt optical emission from GRB 041219a. It is variable and correlated with the prompt gamma-rays, indicating a common origin for the optical light and the gamma-rays. Within the context of the standard fireball model of GRBs, we attribute this new optical component to internal shocks driven into the burst ejecta by variations of the inner engine. The correlated optical emission is a direct probe of the jet isolated from the medium. The timing of the uncorrelated optical emission is strongly dependent on the nature of the medium., Comment: 9 pages, 4 figures. Note: This paper has been accepted for publication in Nature, but is embargoed for discussion in the popular press until formal publication in Nature. Resubmit - Added table comparing Swift and RAPTOR data
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- 2005
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29. A contemporaneous infrared flash from a long gamma-ray burst: an echo from the central engine
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Blake, C. H., Bloom, J. S., Starr, D. L., Falco, E. E., Skrutskie, M., Fenimore, E. E., Duchene, G., Szentgyorgyi, A., Hornstein, S., Prochaska, J. X., McCabe, C., Ghez, A., Konopacky, Q., Stapelfeldt, K., Hurley, K., Campbell, R., Kassis, M., Chaffee, F., Gehrels, N., Barthelmy, S., Cummings, J. R., Hullinger, D., Krimm, H. A., Markwardt, C. B., Palmer, D., Parsons, A., McLean, K., and Tueller, J.
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Astrophysics - Abstract
The explosion that results in a cosmic gamma-ray burst (GRB) is thought to produce emission from two physical processes -- the activity of the central engine gives rise to the high-energy emission of the burst through internal shocking and the subsequent interaction of the flow with the external environment produces long-wavelength afterglow. While afterglow observations continue to refine our understanding of GRB progenitors and relativistic shocks, gamma-ray observations alone have not yielded a clear picture of the origin of the prompt emission nor details of the central engine. Only one concurrent visible-light transient has been found and was associated with emission from an external shock. Here we report the discovery of infrared (IR) emission contemporaneous with a GRB, beginning 7.2 minutes after the onset of GRB 041219a. Our robotic telescope acquired 21 images during the active phase of the burst, yielding the earliest multi-colour observations of any long-wavelength emission associated with a GRB. Analysis of an initial IR pulse suggests an origin consistent with internal shocks. This opens a new possibility to study the central engine of GRBs with ground-based observations at long wavelengths., Comment: Accepted to Nature on March 1, 2005. 9 pages, 4 figures, nature12.cls and nature1.cls files included. This paper is under press embargo until print publication
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- 2005
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30. Adalimumab Biosimilars in Europe: An Overview of the Clinical Evidence
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Bellinvia, Salvatore, Cummings, J. R. Fraser, Ardern-Jones, Michael R., and Edwards, Christopher J.
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- 2019
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31. Validation of the IBD-Control Questionnaire across different sociodemographic and clinical subgroups: secondary analysis of a nationwide electronic survey.
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Gebeyehu, Gerum G, Taylor, Frederick, Dobson, Liz, Cummings, J R Fraser, Bloom, Stuart, Kennedy, Nicholas A, Christiansen, Paul, and Bodger, Keith
- Abstract
Background The IBD-Control Questionnaire is a simple, generic measure of patient-perceived disease control used increasingly in clinical practice and research. We aimed to address knowledge gaps in its psychometric performance, to ensure that it can be used with confidence in a variety of contexts. Methods We analysed 7341 responses to the IBD Registry COVID-19 survey, sent to 40 911 patients who completed an online self-assessment tool during the pandemic. Questions covered demographics, comorbidities, inflammatory bowel disease [IBD] sub-type, and IBD-Control Questionnaire and symptom scores [CD-PRO2 or UC-PRO2]. Psychometric properties of IBD-Control-8 were tested overall and within subgroups (Crohn's disease [CD], ulcerative colitis [UC] and IBD unclassified; male and female; ≤65 and >65 years; number of co-morbidities; deprivation status). Results Internal consistency was very strong overall [α: 0.84, ω: 0.89] and for each subgroup [α range: 0.81–0.85; ω: 0.86–0.90]. Construct validity was demonstrated by moderate correlation of each item with global rating [VAS] [ r
s range: 0.47–0.65], strong correlation between IBD-Control-8 score and VAS [ rs = 0.74], moderate-to-strong with PRO2 scores [CD: rs = −0.718; UC: rs = −0.602] and significantly higher IBD-Control-8 scores for PRO2-remission vs PRO2-active, consistent across subgroups. Exploratory and confirmatory factor analyses demonstrated a two-factor model (items loading onto 'Health-related Quality of Life' [HRQoL] or 'Treatment' domains). Extensive tests for factorial invariance confirmed consistency. Conclusions IBD-Control-8 is a psychometrically robust scale which can be used across a range of populations. It offers a quick, reliable, and valid method of assessing patient-perceived control. The construct of 'control' includes traditional HRQoL and a novel domain relating to treatment perception. [ABSTRACT FROM AUTHOR]- Published
- 2024
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32. MicroRNA-31 Targets Thymic Stromal Lymphopoietin in Mucosal Infiltrated CD4+ T Cells: A Role in Achieving Mucosal Healing in Ulcerative Colitis?
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Whiteoak, Simon R, Claridge, Andrew, Balendran, Clare A, Harris, Richard J, Gwiggner, Markus, Bondanese, Victor P, Erlandsson, Fredrik, Hansen, Mark Berner, Cummings, J R Fraser, and Sanchez-Elsner, Tilman
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- 2018
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33. Prediction of Crohn’s Disease Stricturing Phenotype Using aNOD2-derived Genomic Biomarker
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Ashton, James J, primary, Cheng, Guo, additional, Stafford, Imogen S, additional, Kellermann, Melina, additional, Seaby, Eleanor G, additional, Cummings, J R Fraser, additional, Coelho, Tracy A F, additional, Batra, Akshay, additional, Afzal, Nadeem A, additional, Beattie, R Mark, additional, and Ennis, Sarah, additional
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- 2022
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34. GRB 130427A: A Nearby Ordinary Monster
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Maselli, A., Melandri, A., Nava, L., Mundell, C. G., Kawai, N., Campana, S., Covino, S., Cummings, J. R., Cusumano, G., Evans, P. A., Ghirlanda, G., Ghisellini, G., Guidorzi, C., Kobayashi, S., Kuin, P., La Parola, V., Mangano, V., Oates, S., Sakamoto, T., Serino, M., Virgili, F., Zhang, B.-B., Barthelmy, S., Beardmore, A., Bernardini, M. G., Bersier, D., Burrows, D., Calderone, G., Capalbi, M., Chiang, J., D'Avanzo, P., D'Elia, V., De Pasquale, M., Fugazza, D., Gehrels, N., Gomboc, A., Harrison, R., Hanayama, H., Japelj, J., Kennea, J., Kopac, D., Kouveliotou, C., Kuroda, D., Levan, A., Malesani, D., Marshall, F., Nousek, J., O'Brien, P., Osborne, J. P., Pagani, C., Page, K. L., Page, M., Perri, M., Pritchard, T., Romano, P., Saito, Y., Sbarufatti, B., Salvaterra, R., Steele, I., Tanvir, N., Vianello, G., Weigand, B., Wiersema, K., Yatsu, Y., Yoshii, T., and Tagliaferri, G.
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- 2014
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35. Fermi-LAT Observations of the Gamma-Ray Burst GRB 130427A
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Ackermann, M., Ajello, M., Asano, K., Atwood, W. B., Axelsson, M., Baldini, L., Ballet, J., Barbiellini, G., Baring, M. G., Bastieri, D., Bechtol, K., Bellazzini, R., Bissaldi, E., Bonamente, E., Bregeon, J., Brigida, M., Bruel, P., Buehler, R., Burgess, J. Michael, Buson, S., Caliandro, G. A., Cameron, R. A., Caraveo, P. A., Cecchi, C., Chaplin, V., Charles, E., Chekhtman, A., Cheung, C. C., Chiang, J., Chiaro, G., Ciprini, S., Claus, R., Cleveland, W., Cohen-Tanugi, J., Collazzi, A., Cominsky, L. R., Connaughton, V., Conrad, J., Cutini, S., D'Ammando, F., de Angelis, A., DeKlotz, M., de Palma, F., Dermer, C. D., Desiante, R., Diekmann, A., Di Venere, L., Drell, P. S., Drlica-Wagner, A., Favuzzi, C., Fegan, S. J., Ferrara, E. C., Finke, J., Fitzpatrick, G., Focke, W. B., Franckowiak, A., Fukazawa, Y., Funk, S., Fusco, P., Gargano, F., Gehrels, N., Germani, S., Gibby, M., Giglietto, N., Giles, M., Giordano, F., Giroletti, M., Godfrey, G., Granot, J., Grenier, I. A., Grove, J. E., Gruber, D., Guiriec, S., Hadasch, D., Hanabata, Y., Harding, A. K., Hayashida, M., Hays, E., Horan, D., Hughes, R. E., Inoue, Y., Jogler, T., Jóhannesson, G., Johnson, W. N., Kawano, T., Knödlseder, J., Kocevski, D., Kuss, M., Lande, J., Larsson, S., Latronico, L., Longo, F., Loparco, F., Lovellette, M. N., Lubrano, P., Mayer, M., Mazziotta, M. N., McEnery, J. E., Michelson, P. F., Mizuno, T., Moiseev, A. A., Monzani, M. E., Moretti, E., Morselli, A., Moskalenko, I. V., Murgia, S., Nemmen, R., Nuss, E., Ohno, M., Ohsugi, T., Okumura, A., Omodei, N., Orienti, M., Paneque, D., Pelassa, V., Perkins, J. S., Pesoe-Rollins, M., Petrosian, V., Piron, F., Pivato, G., Porter, T. A., Racusin, J. L, Rainò, S., Rando, R., Razzano, M., Razzaque, S., Reimer, A., Reimer, O., Ritz, S., Roth, M., Ryde, F., Sartori, A., Parkinson, P. M. Saz, Scargle, J. D., Schulz, A., Sgrò, C., Siskind, E. J., Sonbas, E., Spandre, G., Spinelli, P., Tajima, H., Takahashi, H., Thayer, J. G., Thayer, J. A., Thompson, D. J., Tibaldo, L., Tinivella, M., Torres, D. F., Tosti, G., Troja, E., Usher, T. L., Vandenbroucke, J., Vasileiou, V., Vianello, G., Vitale, V., Winer, B. L., Wood, K. S., Yamazaki, R., Younes, G., Yu, H.-F., Zhu, S. J., Bhat, P. N., Briggs, M. S., Byrne, D., Foley, S., Goldstein, A., Jenke, P., Kippen, R. M., Kouveliotou, C., McBreen, S., Meegan, C., Paciesas, W. S., Preece, R., Rau, A., Tierney, D., van der Horst, A. J., von Kienlin, A., Wilson-Hodge, C., Xiong, S., Cusumano, G., La Parola, V., and Cummings, J. R.
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- 2014
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36. Imaging Techniques and Principles of Interpretation
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Nolan, D. J., Wilson, S. R., Balthazar, E. J., Skehan, S. J., Mernagh, J. R., Nahmias, C., Gourtsoyiannis, N. C., Papanikolaou, N., Rieber, A., Brambs, H. J., Prassopoulos, P., Cummings, J. R. Fraser, Morris, A. J., Jackson, J. E., Baert, Albert L., editor, Sartor, K., editor, and Gourtsoyiannis, Nicholas C., editor
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- 2002
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37. Medical Management of Crohn's Disease
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Cummings, J. R. Fraser, Keshav, Satish, and Travis, Simon P. L.
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- 2008
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38. The Isotopic Composition of Anomalous Cosmic Rays from Sampex
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Leske, R. A., Mewaldt, R. A., Cummings, A. C., Cummings, J. R., Stone, E. C., Von Rosenvinge, T. T., Von Steiger, R., editor, Lallement, R., editor, and Lee, M. A., editor
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- 1996
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39. Implications for sequencing of biologic therapy and choice of second anti-TNF in patients with inflammatory bowel disease: results from the IMmunogenicity to Second Anti-TNF therapy (IMSAT) therapeutic drug monitoring study
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Chanchlani, Neil, Lin, Simeng, Auth, Marcus K., Lee, Chai Leng, Robbins, Helena, Looi, Shi, Murugesan, Senthil V., Riley, Tom, Preston, Cathryn, Stephenson, Sophie, Cardozo, Wendy, Sonwalkar, Sunil A., Allah‐ditta, Mohammed, Mansfield, Lynne, Durai, Dharmaraj, Baker, Mark, London, Ian, London, Emily, Gupta, Sanjay, Di Mambro, Alex, Murphy, Aisling, Gaynor, Edward, Jones, Kelsey D. J., Claridge, Andrew, Sebastian, Shaji, Ramachandran, Sankaranarayanan, Selinger, Christian P., Borg‐bartolo, Simon P., Knight, Paul, Sprakes, Michael B., Burton, Julie, Kane, Patricia, Lupton, Stephanie, Fletcher, Aimee, Gaya, Daniel R., Colbert, Roghan, Seenan, John Paul, Macdonald, Jonathan, Lynch, Lucy, Mclachlan, Iain, Shields, Stephanie, Hansen, Richard, Gervais, Lisa, Jere, Mwansa, Akhtar, Muhammad, Black, Karen, Henderson, Paul, Russell, Richard K., Lees, Charlie W., Derikx, Lauranne A. A. P., Lockett, Melanie, Betteridge, Frederica, De Silva, Aminda, Hussenbux, Arif, Beckly, John, Bendall, Oliver, Hart, James W., Thomas, Amanda, Hamilton, Ben, Gordon, Claire, Chee, Desmond, Mcdonald, Timothy J., Nice, Rachel, Parkinson, Marian, Gardner‐thorpe, Helen, Butterworth, Jeff R., Javed, Asima, Al‐shakhshir, Sarah, Yadagiri, Rekha, Maher, Sebrene, Pollok, Richard C. G., Ng, Tze, Appiahene, Priscilla, Donovan, Fiona, Lok, James, Chandy, Rajiv, Jagdish, Reema, Baig, Daniyal, Mahmood, Zahid, Marsh, Liane, Moss, Allison, Abdulgader, Amin, Kitchin, Angus, Walker, Gareth J., George, Becky, Lim, Yuen‐hui, Gulliver, James, Bloom, Stuart, Theaker, Holly, Carlson, Sean, Cummings, J. R. Fraser, Livingstone, Robert, Beale, Amanda, Carter, Josiah O., Bell, Andrew, Coulter, Archibald, Snook, Jonathon, Stone, Helen, Kennedy, Nicholas A., Goodhand, James R., and Ahmad, Tariq
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Biological Therapy ,Tumor Necrosis Factor-alpha ,Adalimumab ,Humans ,Immunologic Factors ,Tumor Necrosis Factor Inhibitors ,Drug Monitoring ,Inflammatory Bowel Diseases ,Antibodies ,Infliximab ,Inflammatory diseases Radboud Institute for Molecular Life Sciences [Radboudumc 5] ,Retrospective Studies - Abstract
Contains fulltext : 288040.pdf (Publisher’s version ) (Open Access) BACKGROUND: Anti-drug antibodies are associated with treatment failure to anti-TNF agents in patients with inflammatory bowel disease (IBD). AIM: To assess whether immunogenicity to a patient's first anti-TNF agent would be associated with immunogenicity to the second, irrespective of drug sequence METHODS: We conducted a UK-wide, multicentre, retrospective cohort study to report rates of immunogenicity and treatment failure of second anti-TNF therapies in 1058 patients with IBD who underwent therapeutic drug monitoring for both infliximab and adalimumab. The primary outcome was immunogenicity to the second anti-TNF agent, defined at any timepoint as an anti-TNF antibody concentration ≥9 AU/ml for infliximab and ≥6 AU/ml for adalimumab. RESULTS: In patients treated with infliximab and then adalimumab, those who developed antibodies to infliximab were more likely to develop antibodies to adalimumab, than patients who did not develop antibodies to infliximab (OR 1.99, 95%CI 1.27-3.20, p = 0.002). Similarly, in patients treated with adalimumab and then infliximab, immunogenicity to adalimumab was associated with subsequent immunogenicity to infliximab (OR 2.63, 95%CI 1.46-4.80, p
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- 2022
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40. Prediction of Crohn's Disease Stricturing Phenotype Using a NOD2-derived Genomic Biomarker.
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Ashton, James J, Cheng, Guo, Stafford, Imogen S, Kellermann, Melina, Seaby, Eleanor G, Cummings, J R Fraser, Coelho, Tracy A F, Batra, Akshay, Afzal, Nadeem A, Beattie, R Mark, and Ennis, Sarah
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- 2023
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41. Transitioning from Intravenous to Subcutaneous Vedolizumab in Patients with Inflammatory Bowel Disease [TRAVELESS]
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Ventress, Esther, primary, Young, David, additional, Rahmany, Sohail, additional, Harris, Clare, additional, Bettey, Marion, additional, Smith, Trevor, additional, Moyses, Helen, additional, Lech, Magdalena, additional, Gwiggner, Markus, additional, Felwick, Richard, additional, and Cummings, J R Fraser, additional
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- 2021
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42. Thiopurine withdrawal during sustained clinical remission in inflammatory bowel disease: relapse and recapture rates, with predictive factors in 237 patients
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Kennedy, N. A., Kalla, R., Warner, B., Gambles, C. J., Musy, R., Reynolds, S., Dattani, R., Nayee, H., Felwick, R., Harris, R., Marriott, S., Senanayake, S. M., Lamb, C. A., Al-Hilou, H., Gaya, D. R., Irving, P. M., Mansfield, J., Parkes, M., Ahmad, T., Cummings, J. R. F., Arnott, I. D., Satsangi, J., Lobo, A. J., Smith, M., Lindsay, J. O., and Lees, C. W.
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- 2014
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43. Understanding the relative contributions of direct environmental effects and passive genotype–environment correlations in the association between familial risk factors and child disruptive behavior disorders
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Bornovalova, M. A., Cummings, J. R., Hunt, E., Blazei, R., Malone, S., and Iacono, W. G.
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- 2014
44. JAK1 inhibition and inflammatory bowel disease
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Harris, Clare, primary and Cummings, J R Fraser, additional
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- 2021
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45. Prompt Emission of GRB 121217A from Gamma-Rays to the Near-Infrared
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Elliott, J, Yu, H.-F, Schmidl, S, Greiner, J, Gruber, D, Oates, S, Kobayashi, S, Zhang, B, Cummings, J. R, Filgas, R, and Gehrels, N
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Astrophysics - Abstract
The mechanism that causes the prompt-emission episode of gamma-ray bursts (GRBs) is still widely debated despite there being thousands of prompt detections. The favoured internal shock model relates this emission to synchrotron radiation. However, it does not always explain the spectral indices of the shape of the spectrum, which is often fit with empirical functions, such as the Band function. Multi-wavelength observations are therefore required to help investigate the possible underlying mechanisms that causes the prompt emission. We present GRB 121217A, for which we were able to observe its near-infrared (NIR) emission during a secondary prompt-emission episode with the Gamma-Ray burst Optical Near-infrared Detector (GROND) in combination with the Swift and Fermi satellites, which cover an energy range of 5 orders of magnitude (10(exp −3) keV to 100 keV). We determine a photometric redshift of z = 3.1 +/- 0.1 with a line-of-sight with little or no extinction (AV approx. 0 mag) utilising the optical/NIR SED. From the afterglow, we determine a bulk Lorentz factor of Gamma(sub 0) approx. 250 and an emission radius of R < 1018 cm. The prompt-emission broadband spectral energy distribution is well fit with a broken power law with beta1 = −0.3 +/- 0.1 and beta2 = 0.6 +/- 0.1 that has a break at E = 6.6 +/- 0.9 keV, which can be interpreted as the maximum injection frequency. Self-absorption by the electron population below energies of Ea < 6 keV suggest a magnetic field strength of B approx. 10(exp 5) G. However, all the best fit models underpredict the flux observed in the NIR wavelengths, which also only rebrightens by a factor of approx. 2 during the second prompt emission episode, in stark contrast to the X-ray emission, which rebrightens by a factor of approx. 100. This suggests an afterglow component is dominating the emission. We present GRB 121217A, one of the few GRBs that has multi-wavelength observations of the prompt-emission period and shows that it can be understood with a synchrotron radiation model. However, due to the complexity of the GRB's emission, other mechanisms that result in Band-like spectra cannot be ruled out.
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- 2014
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46. ENDGAMES
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Wallis, Sebastian P, Mistry, Dipan, Coatesworth, Andrew P, Porte, Michael, Hinton, Jonathan W, Cummings, J R Fraser, and Sedgwick, Philip
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- 2012
47. Killer Ig-like receptor (KIR) genotype and HLA ligand combinations in ulcerative colitis susceptibility
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Jones, D C, Edgar, R S, Ahmad, T, Cummings, J R F, Jewell, D P, Trowsdale, J, and Young, N T
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- 2006
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48. Anomalous Cosmic Rays: The Principal Source of High Energy Heavy Ions in the Radiation Belts
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Mewaldt, R. A., primary, Selesnick, R. S., additional, and Cummings, J. R., additional
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- 2013
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49. Human Intestinal Macrophages Are Involved in the Pathology of Both Ulcerative Colitis and Crohn Disease
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Dharmasiri, Suranga, primary, Garrido-Martin, Eva M, additional, Harris, Richard J, additional, Bateman, Adrian C, additional, Collins, Jane E, additional, Cummings, J R Fraser, additional, and Sanchez-Elsner, Tilman, additional
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- 2021
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50. A short γ-ray burst apparently associated with an elliptical galaxy at redshift z = 0.225
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Gehrels, N., Sarazin, C. L., O'Brien, P. T., Zhang, B., Barbier, L., Barthelmy, S. D., Blustin, A., Burrows, D. N., Cannizzo, J., Cummings, J. R., Goad, M., Holland, S. T., Hurkett, C. P., Kennea, J. A., Levan, A., Markwardt, C. B., Mason, K. O., Meszaros, P., Page, M., Palmer, D. M., Rol, E., Sakamoto, T., Willingale, R., Angelini, L., Beardmore, A., Boyd, P. T., Breeveld, A., Campana, S., Chester, M. M., Chincarini, G., Cominsky, L. R., Cusumano, G., de Pasquale, M., Fenimore, E. E., Giommi, P., Gronwall, C., Grupe, D., Hill, J. E., Hinshaw, D., Hjorth, J., Hullinger, D., Hurley, K. C., Klose, S., Kobayashi, S., Kouveliotou, C., Krimm, H. A., Mangano, V., Marshall, F. E., McGowan, K., Moretti, A., Mushotzky, R. F., Nakazawa, K., Norris, J. P., Nousek, J. A., Osborne, J. P., Page, K., Parsons, A. M., Patel, S., Perri, M., Poole, T., Romano, P., Roming, P. W. A., Rosen, S., Sato, G., Schady, P., Smale, A. P., Sollerman, J., Starling, R., Still, M., Suzuki, M., Tagliaferri, G., Takahashi, T., Tashiro, M., Tueller, J., Wells, A. A., White, N. E., and Wijers, R. A. M. J.
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Environmental issues ,Science and technology ,Zoology and wildlife conservation - Abstract
Author(s): N. Gehrels (corresponding author) [1]; C. L. Sarazin [2]; P. T. O'Brien [3]; B. Zhang [4]; L. Barbier [1]; S. D. Barthelmy [1]; A. Blustin [5]; D. N. Burrows [...]
- Published
- 2005
- Full Text
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