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21 results on '"Cullen, Mark M."'

5. ATRX and Its Prognostic Significance in Soft Tissue Sarcoma.

Author

Cullen, Mark M., Floyd, Warren, Dow, Bobby, Schleupner, Beatrice, Brigman, Brian E., Visgauss, Julia D., Cardona, Diana M., Somarelli, Jason A., and Eward, William C.

Subjects
*NUCLEAR proteins, *SARCOMA, *TUMOR markers, *RETROSPECTIVE studies, *MULTIVARIATE analysis, *EXPERIMENTAL design, *LONGITUDINAL method, *KAPLAN-Meier estimator, *STATISTICS, *SOFT tissue tumors, *PROGRESSION-free survival, *PHENOTYPES, *PROPORTIONAL hazards models, *OVERALL survival
Abstract

Purpose. Recently, the association between ATRX and a more aggressive sarcoma phenotype has been shown. We performed a retrospective study of sarcomas from an individual institution to evaluate ATRX as a prognosticator in soft tissue sarcoma. Experimental Design. 128 sarcomas were collected from a single institution and stained for ATRX. The prognostic significance of these markers was evaluated in a smaller cohort of primary soft tissue sarcomas (n = 68). Kaplan–Meier curves were created for univariate analysis, and Cox regression was utilized for multivariate analysis. Results. High expression of ATRX was found to be a positive prognostic indicator for overall survival and metastasis-free survival in our group of soft tissue sarcomas both in univariate analysis and multivariate analysis (HR: 0.38 (0.17–0.85), P = 0.02 and HR: 0.49 (0.24–0.99), P = 0.05 , respectively). Conclusions. High expression of ATRX is a positive prognostic indicator of overall survival and metastasis-free survival in patients with STS. This is consistent with studies in osteosarcoma, which indicate possible mechanisms through which loss of ATRX leads to more aggressive phenotypes. Future prospective clinical studies are required to validate the prognostic significance of these findings. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Abstract 1061: Exportin 1 (XPO1) inhibition alone or in combination as a novel therapeutic strategy in osteosarcoma

Author

Graves, Laurie, primary, Rupprecht, Gabrielle, additional, Altunel, Erdem, additional, Flamant, Etienne M., additional, Rao, Sneha, additional, Sivara, Dharshan, additional, Lazarides, Alexander L., additional, Hoskinson, Sarah M., additional, Sheth, Maya U., additional, Cheng, Serene, additional, Kim, So Young, additional, Ware, Kathryn E., additional, Agarwal, Anika, additional, Cullen, Mark M., additional, Syal, Casey, additional, Selmic, Laura E., additional, Everitt, Jeffrey I., additional, McCall, Shannon J., additional, Eward, Cindy, additional, Kashyap, Trinayan, additional, Maloof, Marie, additional, Walker, Christopher J., additional, Landesman, Yosef, additional, Wagner, Lars, additional, Eward, William C., additional, Hsu, David S., additional, and Somarelli, Jason A., additional

Published
2022
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10. Corrigendum to ‘Why Do Patients Undergoing Extremity Prosthetic Reconstruction for Metastatic Disease Get Readmitted?’ [The Journal of Arthroplasty 37 (2022) 232-237]

Author

Lazarides, Alexander L., primary, Flamant, Etienne M., additional, Cullen, Mark M., additional, Ferlauto, Harrison R., additional, Goltz, Daniel E., additional, Cochrane, Niall H., additional, Visgauss, Julia D., additional, Brigman, Brian E., additional, and Eward, William C., additional

Published
2022
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12. Investigating readmission rates for patients undergoing oncologic resection and endoprosthetic reconstruction for primary sarcomas and tumors involving bone

Author

Lazarides, Alexander L., primary, Flamant, Etienne M., additional, Cullen, Mark M., additional, Ferlauto, Harrison R., additional, Cochrane, Niall, additional, Gao, Junheng, additional, Jung, Sin‐Ho, additional, Visgauss, Julia D., additional, Brigman, Brian E., additional, and Eward, William C., additional

Published
2022
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15. A Zebrafish Model of Metastatic Colonization Pinpoints Cellular Mechanisms of Circulating Tumor Cell Extravasation

Author

Allen, Tyler A., primary, Cullen, Mark M., additional, Hawkey, Nathan, additional, Mochizuki, Hiroyuki, additional, Nguyen, Lan, additional, Schechter, Elyse, additional, Borst, Luke, additional, Yoder, Jeffrey A., additional, Freedman, Jennifer A., additional, Patierno, Steven R., additional, Cheng, Ke, additional, Eward, William C., additional, and Somarelli, Jason A., additional

Published
2021
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17. A Comparative Oncology Drug Discovery Pipeline to Identify and Validate New Treatments for Osteosarcoma

Author

Somarelli, Jason A., primary, Rupprecht, Gabrielle, additional, Altunel, Erdem, additional, Flamant, Etienne M., additional, Rao, Sneha, additional, Sivaraj, Dharshan, additional, Lazarides, Alexander L., additional, Hoskinson, Sarah M., additional, Sheth, Maya U., additional, Cheng, Serene, additional, Kim, So Young, additional, Ware, Kathryn E., additional, Agarwal, Anika, additional, Cullen, Mark M., additional, Selmic, Laura E., additional, Everitt, Jeffrey I., additional, McCall, Shannon J., additional, Eward, Cindy, additional, Eward, William C., additional, and Hsu, David S., additional

Published
2020
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18. A cross-species drug discovery pipeline to identify and validate new treatments for osteosarcoma

Author

Somarelli, Jason A., primary, Rupprecht, Gabrielle, additional, Altunel, Erdem, additional, Flamant, Etienne M., additional, Rao, Sneha, additional, Sivaraj, Dharshan, additional, Lazarides, Alexander L., additional, Hoskinson, Sarah M., additional, Sheth, Maya U., additional, Cheng, Serene, additional, Kim, So Young, additional, Ware, Kathryn E., additional, Agarwal, Anika, additional, Cullen, Mark M., additional, Selmic, Laura E., additional, Everitt, Jeffrey I., additional, McCall, Shannon J., additional, Eward, Cindy, additional, Eward, William C., additional, and Hsu, S. David, additional

Published
2020
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21. Humeral Shaft Fracture With Placement of an Intramedullary Nail Through an Unrecognized Sarcoma.

Author

Cullen MM, Okwumabua E, Flamant EM, Ferlauto HR, Brigman BE, and Eward WC

Subjects
Aged, Bone Nails adverse effects, Humans, Humerus diagnostic imaging, Male, Neoplasm Recurrence, Local, Fracture Fixation, Intramedullary adverse effects, Humeral Fractures diagnostic imaging, Sarcoma diagnostic imaging
Abstract

Case: A 72-year-old man underwent intramedullary nailing of a humeral diaphysis fracture with passage through an unrecognized pathologic fracture. Four months later, a biopsy of a soft-tissue mass in the arm revealed pleomorphic undifferentiated sarcoma. Only after local recurrence and forequarter amputation was the story of a pathologic fracture through undifferentiated pleomorphic sarcomas of bone clear. The patient developed metastatic disease and died after 2 years postoperatively., Discussion: Orthopaedic surgeons should consider sarcoma when assessing patients with fractures of unknown etiology and an inappropriate mechanism because the placement of an intramedullary device through a sarcoma of bone has consequences., (Copyright © 2021 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Orthopaedic Surgeons.)

Published
2021
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