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3. A Randomised, Double-Blind, Controlled Efficacy Trial of the LiESP/QA-21 Vaccine in Naïve Dogs Exposed to Two Leishmania infantum Transmission Seasons

Author

Oliva, Gaetano, primary, Nieto, Javier, additional, Foglia Manzillo, Valentina, additional, Cappiello, Silvia, additional, Fiorentino, Eleonora, additional, Di Muccio, Trentina, additional, Scalone, Aldo, additional, Moreno, Javier, additional, Chicharro, Carmen, additional, Carrillo, Eugenia, additional, Butaud, Therese, additional, Guegand, Laurie, additional, Martin, Virginie, additional, Cuisinier, Anne-Marie, additional, McGahie, David, additional, Gueguen, Sylvie, additional, Cañavate, Carmen, additional, and Gradoni, Luigi, additional

Published
2014
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11. Vaccination with LiESP/QA-21 (CaniLeish®) reduces the intensity of infection in Phlebotomus perniciosus fed on Leishmania infantum infected dogs-A preliminary xenodiagnosis study.

Author

Bongiorno, Gioia, Paparcone, Rosa, Manzillo, Valentina Foglia, Oliva, Gaetano, Cuisinier, Anne-Marie, and Gradoni, Luigi

Subjects
*LEISHMANIASIS in dogs, *PHLEBOTOMUS, *LEISHMANIA infantum, *XENODIAGNOSIS, *ANIMAL vaccination, *POLYMERASE chain reaction
Abstract

Abstract: Ten Beagle dogs at different stages of Leishmania infantum infection, among which 6 had received a full course of LiESP/QA-21 (CaniLeish®; Virbac) vaccination, were exposed to the bites of reared Phlebotomus perniciosus to assesses their infectiousness potential. This was found to be negligible/nil in 2 seronegative dogs with subpatent infection. Among the 8 dogs with active infection (=positive serology, bone-marrow qualitative PCR and lymph node culture), 2/5 vaccinated (40.0%) and 2/3 nonvaccinated dogs (66.7%) were infectious to the sand flies (p =0.5). However significantly fewer of the sand flies which fed on the vaccinated dogs were infected when compared to those which fed on the control dogs (10/82 compared to 30/49) (chi-squared test, p <0.0001; mixed binomial model with the dog identity included as a random effect, p =0.03). Furthermore, there was a significant difference in the proportion of sand flies with >500 parasites in their gut (i.e. a higher risk for subsequent transmission): 3.7% for vaccinated dogs compared with 28.6% for nonvaccinated dogs (Fisher's exact test, p <0.0001; binomial mixed model, p =0.006). Although preliminary, these results suggest value in further investigations on L. infantum transmissibility parameters in LiESP/QA-21 vaccinated dogs. [Copyright &y& Elsevier]

Published
2013
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