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2 results on '"Cui, Y. (Yijun)"'

1. WSES guidelines for emergency repair of complicated abdominal wall hernias

Author

Sartelli, M. (Massimo), Coccolini, F. (Federico), Ramshorst, G.H. (Gabrielle) van, Campanelli, G. (Giampiero), Mandala, V., Ansaloni, L. (Luca), Moore, E.E. (Ernest), Peitzman, A. (Andrew), Velmahos, G.C. (George ), Moore, F.A. (Fredrick), Leppaniemi, A. (Ari), Burlew, C.C. (Clay), Biffl, W.L. (Walter), Koike, K. (Kaoru), Kluger, Y. (Yoram), Fraga, G.P. (Gustavo), Ordonez, C.A. (Carlos), Di Saverio, S. (Salomone), Agresta, F., Sakakushev, B. (Boris), Gerych, I. (Igor), Wani, I. (Imtiaz), Kelly, M.D. (Michael ), Gomes, C.A. (Carlos), Faro Jr., M.P. (Mario), Taviloglu, K. (Korhan), Demetrashvili, Z. (Zaza), Lee, J.G. (Jeong ), Vettoretto, N. (Nereo), Guercioni, G. (Gianluca), Tranà, C. (Cristian), Cui, Y. (Yijun), Kok, K.Y.Y. (Kenneth), Ghnnam, W.M. (Wagih), Abbas, A.E.S. (Ashraf El-Sayed), Sato, N. (Norio), Marwah, S. (Sanjay), Rangarajan, M. (Muthukumaran), Ben-Ishay, O. (Offir), Adesunkanmi, A.R.K. (Abdul Rashid), Segovia Lohse, H.A. (Helmut), Kenig, J. (Jakub), Mandalà, V. (Vincenzo), Patrizi, A. (Andrea), Scibé, R. (Rodolfo), Catena, F. (Fausto), Sartelli, M. (Massimo), Coccolini, F. (Federico), Ramshorst, G.H. (Gabrielle) van, Campanelli, G. (Giampiero), Mandala, V., Ansaloni, L. (Luca), Moore, E.E. (Ernest), Peitzman, A. (Andrew), Velmahos, G.C. (George ), Moore, F.A. (Fredrick), Leppaniemi, A. (Ari), Burlew, C.C. (Clay), Biffl, W.L. (Walter), Koike, K. (Kaoru), Kluger, Y. (Yoram), Fraga, G.P. (Gustavo), Ordonez, C.A. (Carlos), Di Saverio, S. (Salomone), Agresta, F., Sakakushev, B. (Boris), Gerych, I. (Igor), Wani, I. (Imtiaz), Kelly, M.D. (Michael ), Gomes, C.A. (Carlos), Faro Jr., M.P. (Mario), Taviloglu, K. (Korhan), Demetrashvili, Z. (Zaza), Lee, J.G. (Jeong ), Vettoretto, N. (Nereo), Guercioni, G. (Gianluca), Tranà, C. (Cristian), Cui, Y. (Yijun), Kok, K.Y.Y. (Kenneth), Ghnnam, W.M. (Wagih), Abbas, A.E.S. (Ashraf El-Sayed), Sato, N. (Norio), Marwah, S. (Sanjay), Rangarajan, M. (Muthukumaran), Ben-Ishay, O. (Offir), Adesunkanmi, A.R.K. (Abdul Rashid), Segovia Lohse, H.A. (Helmut), Kenig, J. (Jakub), Mandalà, V. (Vincenzo), Patrizi, A. (Andrea), Scibé, R. (Rodolfo), and Catena, F. (Fausto)

Abstract

Emergency repair of complicated abdominal hernias is associated with poor prognosis and a high rate of post-operative complications. A World Society of Emergency Surgery (WSES) Consensus Conference was held in Bergamo in July 2013, during the 2nd Congress of the World Society of Emergency Surgery with the goal of defining recommendations for emergency repair of abdominal wall hernias in adults. This document represents the executive summary of the consensus conference approved by a WSES expert panel.

Published
2013
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2. Neurofibromin Regulation of ERK Signaling Modulates GABA Release and Learning

Author

Cui, Y. (Yijun), Costa, R.M. (Rui), Murphy, G.G. (Geoffrey), Elgersma, Y. (Ype), Zhu, Y. (Yuan), Gutmann, D.H. (David), Parada, L.F. (Luis), Mody, I. (Istvan), Silva, A.J. (Alcino), Cui, Y. (Yijun), Costa, R.M. (Rui), Murphy, G.G. (Geoffrey), Elgersma, Y. (Ype), Zhu, Y. (Yuan), Gutmann, D.H. (David), Parada, L.F. (Luis), Mody, I. (Istvan), and Silva, A.J. (Alcino)

Abstract

We uncovered a role for ERK signaling in GABA release, long-term potentiation (LTP), and learning, and show that disruption of this mechanism accounts for the learning deficits in a mouse model for learning disabilities in neurofibromatosis type I (NF1). Our results demonstrate that neurofibromin modulates ERK/synapsin I-dependent GABA release, which in turn modulates hippocampal LTP and learning. An Nf1 heterozygous null mutation, which results in enhanced ERK and synapsin I phosphorylation, increased GABA release in the hippocampus, and this was reversed by pharmacological downregulation of ERK signaling. Importantly, the learning deficits associated with the Nf1 mutation were rescued by a subthreshold dose of a GABAAantagonist. Accordingly, Cre deletions of Nf1 showed that only those deletions involving inhibitory neurons caused hippocampal inhibition, LTP, and learning abnormalities. Importantly, our results also revealed lasting increases in GABA release triggered by learning, indicating that the mechanisms uncovered here are of general importance for learning.

Published
2008
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